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sepsis Hemodynamic ventilator ARDS

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https://www.readbyqxmd.com/read/27316915/french-intensive-care-society-international-congress-r%C3%A3-animation-2016
#1
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27038480/experts-opinion-on-management-of-hemodynamics-in-ards-patients-focus-on-the-effects-of-mechanical-ventilation
#2
REVIEW
A Vieillard-Baron, M Matthay, J L Teboul, T Bein, M Schultz, S Magder, J J Marini
RATIONALE: Acute respiratory distress syndrome (ARDS) is frequently associated with hemodynamic instability which appears as the main factor associated with mortality. Shock is driven by pulmonary hypertension, deleterious effects of mechanical ventilation (MV) on right ventricular (RV) function, and associated-sepsis. Hemodynamic effects of ventilation are due to changes in pleural pressure (Ppl) and changes in transpulmonary pressure (TP). TP affects RV afterload, whereas changes in Ppl affect venous return...
May 2016: Intensive Care Medicine
https://www.readbyqxmd.com/read/26261640/total-ginsenosides-synergize-with-ulinastatin-against-septic-acute-lung-injury-and-acute-respiratory-distress-syndrome
#3
RANDOMIZED CONTROLLED TRIAL
Rongju Sun, Yana Li, Wei Chen, Fei Zhang, Tanshi Li
Total ginsenosides synergize with ulinastatin (UTI) against septic acute lung injury (ALI) and acute respiratory distress syndrome (ARDS). We randomly divided 80 cases of severe sepsis-induced ALI and ARDS into a UTI group and a ginsenosides (GS)+UTI group. Continuous electrocardiac monitoring of pulse, respiratory rate, blood pressure, and heart rate; invasive hemodynamic monitoring; ventilator-assisted breathing and circulation support; and anti-infection as well as UTI treatment were given in the UTI group with GS treatment added for 7 consecutive days in the GS+UTI group...
2015: International Journal of Clinical and Experimental Pathology
https://www.readbyqxmd.com/read/26180495/effects-of-propofol-and-midazolam-on-the-inflammation-of-lungs-after-intravenous-endotoxin-administration-in-rats
#4
Mine Gursac Celik, Ayten Saracoglu, Tolga Saracoglu, Husnu Kursad, Aysenur Dostbil, Mehmet Aksoy, Ali Ahiskalioglu, Ilker Ince
OBJECTIVE: Pulmonary complications are important sepsis (such as ARDS, diffuse pneumonia). Acute respiratory distress syndrome (ARDS) is characterized by the extensive migration of neutrophils into alveoli of the lungs. Propofol and midazolam are the most widely used agents for sedation in intensive care units. Aimed to investigate the effects of anaesthesia with propofol and midazolam on measured hemodynamic variables and neutrophil migration induced by Escherichia Coli endotoxin (ECE) in pulmonary viscera...
June 2015: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/25774737/-do-we-use-the-wrong-target-value-for-the-supportive-therapy-of-sepsis
#5
Dieter Köhler
Sepsis is a generalized, usually infectious disease with a complex dsyregulated immune response and capillary leak. The leakage leads to a severe drop of blood pressure with hypoperfusion and sympathetic counterregulation. The lung is frequently involved either as a source of the inflammation or by emergence of an ARDS, both resulting into severe hypoxemia. The supportive therapy is used to stabilize the hemodynamics and to keep the target value partial pressure of arterial oxygen (PaO2) in the lower limit of normal...
March 2015: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/25261559/carbon-dioxide-in-the-critically-ill-too-much-or-too-little-of-a-good-thing
#6
REVIEW
Jonathan Marhong, Eddy Fan
Hypercapnia and hypocapnia commonly complicate conditions that are present in critically ill patients. Both conditions have important physiologic effects that may impact the clinical management of these patients. For instance, hypercapnia results in bronchodilation and enhanced hypoxic vasoconstriction, leading to improved ventilation/perfusion matching. Hypocapnia reduces cerebral blood volume through arterial vasoconstriction. These effects have also been exploited for therapeutic aims. In patients with traumatic brain injury (TBI), hypocapnia is often utilized to control intracranial pressure...
October 2014: Respiratory Care
https://www.readbyqxmd.com/read/25189285/low-tidal-volume-pressure-support-versus-controlled-ventilation-in-early-experimental-sepsis-in-pigs
#7
COMPARATIVE STUDY
Alexander Ziebart, Erik K Hartmann, Rainer Thomas, Tanghua Liu, Bastian Duenges, Arno Schad, Marc Bodenstein, Serge C Thal, Matthias David
BACKGROUND: In moderate acute respiratory distress syndrome (ARDS) several studies support the usage of assisted spontaneous breathing modes. Only limited data, however, focus on the application in systemic sepsis and developing lung injury. The present study examines the effects of immediate initiation of pressure support ventilation (PSV) in a model of sepsis-induced ARDS. METHODS: 18 anesthetized pigs received a two-staged continuous lipopolysaccharide infusion to induce lung injury...
2014: Respiratory Research
https://www.readbyqxmd.com/read/24731244/mechanical-ventilation-drives-pneumococcal-pneumonia-into-lung-injury-and-sepsis-in-mice-protection-by-adrenomedullin
#8
Holger C Müller-Redetzky, Daniel Will, Katharina Hellwig, Wolfgang Kummer, Thomas Tschernig, Uwe Pfeil, Renate Paddenberg, Michael D Menger, Olivia Kershaw, Achim D Gruber, Norbert Weissmann, Stefan Hippenstiel, Norbert Suttorp, Martin Witzenrath
INTRODUCTION: Ventilator-induced lung injury (VILI) contributes to morbidity and mortality in acute respiratory distress syndrome (ARDS). Particularly pre-injured lungs are susceptible to VILI despite protective ventilation. In a previous study, the endogenous peptide adrenomedullin (AM) protected murine lungs from VILI. We hypothesized that mechanical ventilation (MV) contributes to lung injury and sepsis in pneumonia, and that AM may reduce lung injury and multiple organ failure in ventilated mice with pneumococcal pneumonia...
2014: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/24229378/inhibition-of-poly-adenosine-diphosphate-ribose-polymerase-attenuates-lung-kidney-crosstalk-induced-by-intratracheal-lipopolysaccharide-instillation-in-rats
#9
May Khin Hnin Si, Chieko Mitaka, Miniwan Tulafu, Shinya Abe, Masanobu Kitagawa, Satoshi Ikeda, Yoshinobu Eishi, Shunichi Kurata, Makoto Tomita
BACKGROUND: Acute respiratory distress syndrome (ARDS) is a severe form of lung injury that frequently occurs during pneumonia and sepsis. Lung inflammation in ARDS patients may have deleterious effects on remote organs such as the kidney. The nuclear enzyme poly(adenosine diphosphate-ribose) polymerase (PARP) enhances the nuclear factor (NF)-κB-dependent transcription of inflammatory cytokines. This study was conducted to elucidate two questions: first, whether the activation of PARP and NF-κB mediates the renal inflammation secondary to the lipopolysaccharide (LPS)-induced acute lung inflammation; second, whether a PARP inhibitor, 3-aminobenzamide (3-AB), attenuates lung and kidney inflammation by inhibiting NF-κB-dependent proinflammatory cytokines...
2013: Respiratory Research
https://www.readbyqxmd.com/read/23754904/controversial-treatment-of-a-victim-of-severe-head-injury-complicated-by-septic-shock-and-acute-respiratory-distress-syndrome
#10
Anniken Haavind, Olav Hevrøy, Rune Hennig, Lars Bjertnaes
Pneumonia, severe sepsis, and acute respiratory distress syndrome (ARDS) are frequent complications after head trauma. Recombinant human activated protein C (APC) reportedly improves circulation and respiration in severe sepsis, but is contraindicated after head injury because of increased risk of intracranial bleeding. A 21-year-old man with severe head injury after a car accident was endotracheally intubated, mechanically ventilated, and hemodynamically stabilized before transfer to our university hospital...
2011: International Medical Case Reports Journal
https://www.readbyqxmd.com/read/23370121/pulse-pressure-variation-and-ards
#11
REVIEW
J L Teboul, X Monnet
Fluid management is a crucial issue in patients with acute respiratory distress syndrome (ARDS). Assessment of preload responsiveness should help to define the best fluid strategy. Arterial pulse pressure variation (PPV), which represents the amplitude of the respiratory changes in arterial pulse pressure, is considered as a marker of preload responsiveness in patients mechanically ventilated and fully adapted to their ventilator. The good ability of PPV to predict fluid responsiveness has been confirmed in various clinical situations (sepsis, operative and post-operative periods)...
April 2013: Minerva Anestesiologica
https://www.readbyqxmd.com/read/23361625/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2012
#12
R P Dellinger, Mitchell M Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M Opal, Jonathan E Sevransky, Charles L Sprung, Ivor S Douglas, Roman Jaeschke, Tiffany M Osborn, Mark E Nunnally, Sean R Townsend, Konrad Reinhart, Ruth M Kleinpell, Derek C Angus, Clifford S Deutschman, Flavia R Machado, Gordon D Rubenfeld, Steven Webb, Richard J Beale, Jean-Louis Vincent, Rui Moreno
OBJECTIVE: To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. DESIGN: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict of interest policy was developed at the onset of the process and enforced throughout...
February 2013: Intensive Care Medicine
https://www.readbyqxmd.com/read/23353941/surviving-sepsis-campaign-international-guidelines-for-management-of-severe-sepsis-and-septic-shock-2012
#13
R Phillip Dellinger, Mitchell M Levy, Andrew Rhodes, Djillali Annane, Herwig Gerlach, Steven M Opal, Jonathan E Sevransky, Charles L Sprung, Ivor S Douglas, Roman Jaeschke, Tiffany M Osborn, Mark E Nunnally, Sean R Townsend, Konrad Reinhart, Ruth M Kleinpell, Derek C Angus, Clifford S Deutschman, Flavia R Machado, Gordon D Rubenfeld, Steven A Webb, Richard J Beale, Jean-Louis Vincent, Rui Moreno
OBJECTIVE: To provide an update to the "Surviving Sepsis Campaign Guidelines for Management of Severe Sepsis and Septic Shock," last published in 2008. DESIGN: A consensus committee of 68 international experts representing 30 international organizations was convened. Nominal groups were assembled at key international meetings (for those committee members attending the conference). A formal conflict of interest policy was developed at the onset of the process and enforced throughout...
February 2013: Critical Care Medicine
https://www.readbyqxmd.com/read/23157105/-case-report-of-anesthesia-with-veno-veno-extracorporeal-membrane-oxygenation-v-v-ecmo-during-one-lung-ventilation-for-acute-respiratory-distress-syndrome-ards-complicated-with-severe-sepsis-due-to-spontaneous-esophageal-rupture
#14
Yuichi Ono, Yoshinori Ohta, Gaku Matsumoto, Shiei Kim, Hiroyuki Yokota, Atsuhiro Sakamoto
A 55-year-old man was transferred to our hospital with spontaneous esophageal rupture. An emergency operation of mediastinum drainage by thoracotomy was performed. On postoperative day 8, he had new abcesses located at the upper mediastinum around the esophagus, and required another operation. But one-lung ventilation for the operation was difficult, because of profound hypoxia caused by the acute respiratory distress syndrome (ARDS) with severe sepsis. Therefore we introduced V-V ECMO for the treatment of severe hypoxia and could anesthetize him safely during surgical operation...
October 2012: Masui. the Japanese Journal of Anesthesiology
https://www.readbyqxmd.com/read/22846945/early-stabilizing-alveolar-ventilation-prevents-acute-respiratory-distress-syndrome-a-novel-timing-based-ventilatory-intervention-to-avert-lung-injury
#15
COMPARATIVE STUDY
Shreyas Roy, Benjamin Sadowitz, Penny Andrews, Louis A Gatto, William Marx, Lin Ge, Guirong Wang, Xin Lin, David A Dean, Michael Kuhn, Auyon Ghosh, Joshua Satalin, Kathy Snyder, Yoram Vodovotz, Gary Nieman, Nader Habashi
BACKGROUND: Established acute respiratory distress syndrome (ARDS) is often refractory to treatment. Clinical trials have demonstrated modest treatment effects, and mortality remains high. Ventilator strategies must be developed to prevent ARDS. HYPOTHESIS: Early ventilatory intervention will block progression to ARDS if the ventilator mode (1) maintains alveolar stability and (2) reduces pulmonary edema formation. METHODS: Yorkshire pigs (38-45 kg) were anesthetized and subjected to a "two-hit" ischemia-reperfusion and peritoneal sepsis...
August 2012: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/21997128/the-alien-study-incidence-and-outcome-of-acute-respiratory-distress-syndrome-in-the-era-of-lung-protective-ventilation
#16
MULTICENTER STUDY
Jesús Villar, Jesús Blanco, José Manuel Añón, Antonio Santos-Bouza, Lluís Blanch, Alfonso Ambrós, Francisco Gandía, Demetrio Carriedo, Fernando Mosteiro, Santiago Basaldúa, Rosa Lidia Fernández, Robert M Kacmarek
PURPOSE: While our understanding of the pathogenesis and management of acute respiratory distress syndrome (ARDS) has improved over the past decade, estimates of its incidence have been controversial. The goal of this study was to examine ARDS incidence and outcome under current lung protective ventilatory support practices before and after the diagnosis of ARDS. METHODS: This was a 1-year prospective, multicenter, observational study in 13 geographical areas of Spain (serving a population of 3...
December 2011: Intensive Care Medicine
https://www.readbyqxmd.com/read/21642654/acute-respiratory-distress-syndrome-and-acute-lung-injury
#17
REVIEW
A Dushianthan, M P W Grocott, A D Postle, R Cusack
Acute respiratory distress syndrome (ARDS) is a life threatening respiratory failure due to lung injury from a variety of precipitants. Pathologically ARDS is characterised by diffuse alveolar damage, alveolar capillary leakage, and protein rich pulmonary oedema leading to the clinical manifestation of poor lung compliance, severe hypoxaemia, and bilateral infiltrates on chest radiograph. Several aetiological factors associated with the development of ARDS are identified with sepsis, pneumonia, and trauma with multiple transfusions accounting for most cases...
September 2011: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/19373455/moderate-hypercapnia-exerts-beneficial-effects-on-splanchnic-energy-metabolism-during-endotoxemia
#18
Alex Gnaegi, François Feihl, Olivier Boulat, Bernard Waeber, Lucas Liaudet
PURPOSE: Low tidal volume ventilation and permissive hypercapnia are required in patients with sepsis complicated by ARDS. The effects of hypercapnia on tissue oxidative metabolism in this setting are unknown. We therefore determined the effects of moderate hypercapnia on markers of systemic and splanchnic oxidative metabolism in an animal model of endotoxemia. METHODS: Anesthetized rats maintained at a PaCO(2) of 30, 40 or 60 mmHg were challenged with endotoxin...
July 2009: Intensive Care Medicine
https://www.readbyqxmd.com/read/17092413/-effect-of-high-volume-hemofiltration-on-respiration-hemodynamics-and-oxygen-metabolism-in-sepsis-with-acute-respiratory-distress-syndrome
#19
Chang-wen Liu, Yong-ke Zheng, Jun Lu, Ke-yi Zhu, Wei Hu, Wei-hang Hu
OBJECTIVE: To investigate the effect of continuous high volume hemofiltration (HVHF) on respiration, hemodynamics, and oxygen metabolism in severe sepsis patients with acute respiratory distress syndrome (ARDS). METHODS: Twelve adult patients with ARDS received mechanical ventilation and HVHF (80 mlxkg(-1)xh(-1)) lasting 12-18 hours every day. The cardiac output (CO), systemic vascular resistance (SVR), pulmonary vascular resistance (PVR), mean pulmonary arterial pressure (MPAP), pulmonary artery wedge pressure (PAWP), arterial oxygen content (CaO(2)), O(2) content of mixed venous blood (CvO(2)), oxygen consumption (VO(2)), oxygen delivery (DO(2)) and oxygen extraction rate (O(2)ER) were measured with the aid of a Swan-Ganz catheter, the thoracic fluid content (TFC) were measured with BioZ(r) Cardio Dynamics...
November 2006: Zhongguo Wei Zhong Bing Ji Jiu Yi Xue, Chinese Critical Care Medicine, Zhongguo Weizhongbing Jijiuyixue
https://www.readbyqxmd.com/read/17006068/short-term-cardiorespiratory-effects-of-proportional-assist-and-pressure-support-ventilation-in-patients-with-acute-lung-injury-acute-respiratory-distress-syndrome
#20
RANDOMIZED CONTROLLED TRIAL
Eumorfia Kondili, Nectaria Xirouchaki, Katerina Vaporidi, Maria Klimathianaki, Dimitris Georgopoulos
BACKGROUND: Recent data indicate that assisted modes of mechanical ventilation improve pulmonary gas exchange in patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS). Proportional assist ventilation (PAV) is a new mode of support that amplifies the ventilatory output of the patient effort and improves patient-ventilator synchrony. It is not known whether this mode may be used in patients with ALI/ARDS. The aim of this study was to compare the effects of PAV and pressure-support ventilation on breathing pattern, hemodynamics, and gas exchange in a homogenous group of patients with ALI/ARDS due to sepsis...
October 2006: Anesthesiology
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