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Autism and vaccines

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https://www.readbyqxmd.com/read/28164085/public-private-partnerships-in-cloud-computing-services-in-the-context-of-genomic-research
#1
REVIEW
Palmira Granados Moreno, Yann Joly, Bartha Maria Knoppers
Public-private partnerships (PPPs) have been increasingly used to spur and facilitate innovation in a number of fields. In healthcare, the purpose of using a PPP is commonly to develop and/or provide vaccines and drugs against communicable diseases, mainly in developing or underdeveloped countries. With the advancement of technology and of the area of genomics, these partnerships also focus on large-scale genomic research projects that aim to advance the understanding of diseases that have a genetic component and to develop personalized treatments...
2017: Frontiers in Medicine
https://www.readbyqxmd.com/read/28160764/vaccination-attitudes-and-practices-of-integrative-medicine-physicians
#2
Laura Jean Buehning, Kenneth Michael Peddecord
Context • The growth of Internet-based information and social networking has increased the accessibility and importance of antivaccine information. That information has led to a questioning of vaccination schedules and policies by many individuals. Although the attitudes of complementary and alternative practitioners, such as homeopaths and chiropractic students, toward vaccination have been assessed, despite the growth of integrative medicine, no assessment of the attitudes and practices regarding vaccination of these physicians has been performed...
January 2017: Alternative Therapies in Health and Medicine
https://www.readbyqxmd.com/read/28154539/temporal-association-of-certain-neuropsychiatric-disorders-following-vaccination-of-children-and-adolescents-a-pilot-case-control-study
#3
Douglas L Leslie, Robert A Kobre, Brian J Richmand, Selin Aktan Guloksuz, James F Leckman
BACKGROUND: Although the association of the measles, mumps, and rubella vaccine with autism spectrum disorder has been convincingly disproven, the onset of certain brain-related autoimmune and inflammatory disorders has been found to be temporally associated with the antecedent administration of various vaccines. This study examines whether antecedent vaccinations are associated with increased incidence of obsessive-compulsive disorder (OCD), anorexia nervosa (AN), anxiety disorder, chronic tic disorder, attention deficit hyperactivity disorder, major depressive disorder, and bipolar disorder in a national sample of privately insured children...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28105642/what-do-popular-youtube-tm-videos-say-about-vaccines
#4
C H Basch, P Zybert, R Reeves, C E Basch
BACKGROUND: The unregulated social network YouTube(TM) has become an increasingly popular source of information on health topics such as vaccine safety. With a reach of over one billion users per month, the potential for misinformation is significant. METHODS: Using the keywords 'vaccine safety' and 'vaccines and children', 87 of the most widely viewed YouTube(TM) videos were identified and analyzed for content, author status and view count. RESULTS: The range of view counts was 25 532 to 6 229 835, with a median of 62 075 views per video...
January 19, 2017: Child: Care, Health and Development
https://www.readbyqxmd.com/read/28102992/environmental-factors-associated-with-autism-spectrum-disorder-a-scoping-review-for-the-years-2003-2013
#5
M Ng, J G de Montigny, M Ofner, M T Do
INTRODUCTION: The number of children diagnosed with autism spectrum disorder (ASD) has been rapidly rising in the past decade. The etiology of this disorder, however, is largely unknown, although the environmental relative to the genetic contribution is substantial. We conducted a scoping review to comprehensively assess the current state of knowledge of the environmental factors present from preconception to early life associated with ASD, and to identify research gaps. METHODS: We searched electronic databases MEDLINE, PsycINFO and ERIC for articles on potential risk factors or protective factors from the physical and social environments associated with ASD and its subclassifications published between 1 January, 2003, and 12 July, 2013...
January 2017: Health Promotion and Chronic Disease Prevention in Canada
https://www.readbyqxmd.com/read/28031551/a-two-phase-case-control-study-of-autism-risk-among-children-born-from-the-late-1990s-through-the-early-2000s-in-the-united-states
#6
David A Geier, Janet K Kern, Mark R Geier
BACKGROUND This study evaluated the hypothesis that the 1999 recommendation by the American Academy of Pediatrics (AAP) and US Public Health Service (PHS) to reduce exposure to mercury (Hg) from Thimerosal in US vaccines would be associated with a reduction in the long-term risk of being diagnosed with autism. MATERIAL AND METHODS A two-phase assessment utilizing a case (n=73) -control (n=11,783) study in the Vaccine Adverse Event Reporting System (VAERS) database (for hypothesis generating) and a more rigorous, independent matched case (n=40) -control (n=40) study (hypothesis testing) was undertaken...
December 29, 2016: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/27893896/association-between-influenza-infection-and-vaccination-during-pregnancy-and-risk-of-autism-spectrum-disorder
#7
Ousseny Zerbo, Yinge Qian, Cathleen Yoshida, Bruce H Fireman, Nicola P Klein, Lisa A Croen
Importance: Maternal infections and fever during pregnancy are associated with increased risk for autism spectrum disorders (ASDs). To our knowledge, no study has investigated the association between influenza vaccination during pregnancy and ASD. Objective: To investigate the association between influenza infection and vaccination during pregnancy and ASD risk. Design, Setting, and Participants: This cohort study included 196 929 children born at Kaiser Permanente Northern California from January 1, 2000 to December 31, 2010, at a gestational age of at least 24 weeks...
January 2, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/27876690/-mommy-blogs-and-the-vaccination-exemption-narrative-results-from-a-machine-learning-approach-for-story-aggregation-on-parenting-social-media-sites
#8
Timothy R Tangherlini, Vwani Roychowdhury, Beth Glenn, Catherine M Crespi, Roja Bandari, Akshay Wadia, Misagh Falahi, Ehsan Ebrahimzadeh, Roshan Bastani
BACKGROUND: Social media offer an unprecedented opportunity to explore how people talk about health care at a very large scale. Numerous studies have shown the importance of websites with user forums for people seeking information related to health. Parents turn to some of these sites, colloquially referred to as "mommy blogs," to share concerns about children's health care, including vaccination. Although substantial work has considered the role of social media, particularly Twitter, in discussions of vaccination and other health care-related issues, there has been little work on describing the underlying structure of these discussions and the role of persuasive storytelling, particularly on sites with no limits on post length...
November 22, 2016: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/27836435/vaccine-safety-evaluation-practical-aspects-in-assessing-benefits-and-risks
#9
Alberta Di Pasquale, Paolo Bonanni, Nathalie Garçon, Lawrence R Stanberry, Mostafa El-Hodhod, Fernanda Tavares Da Silva
Vaccines are different from most medicines in that they are administered to large and mostly healthy populations including infants and children, so there is a low tolerance for potential risks or side-effects. In addition, the long-term benefits of immunisation in reducing or eliminating infectious diseases may induce complacency due to the absence of cases. However, as demonstrated in recent measles outbreaks in Europe and United States, reappearance of the disease occurs as soon as vaccine coverage falls...
December 20, 2016: Vaccine
https://www.readbyqxmd.com/read/27783610/-vaccines-history-and-stories-between-reality-and-imagination
#10
Elisa Terracciano, Ermanno Zorzoli, Gian Loreto D'Alò, Laura Zaratti, Elisabetta Franco
Vaccinations and the controversy around them always go in parallel. We identified four categories blending in various amounts of truth and imagination: history, myths, shams and frauds. Over the years, they have alternated and sometimes transformed into one another. This sharp separation into categories is certainly academic and forced. In fact, the line between these aspects is not clear enough to allow a rigid and well-defined division. Our work starts from the category containing the most truthfulness: history, and goes on to analyze two categories that add fantasy to facts: myths and shams (or better, "old wives' tales")...
July 2016: Igiene e Sanità Pubblica
https://www.readbyqxmd.com/read/27738716/effects-of-thimerosal-on-lipid-bilayers-and-human-erythrocytes-an-in-vitro-study
#11
Mario Suwalsky, Pablo Zambrano, María José Gallardo, Fernando Villena, Malgorzata Jemiola-Rzeminska, Kazimierz Strzalka
Thimerosal (THI, ethyl-mercury thiosalicylate) is added to vaccines as a preservative; as a consequence, infants may have been exposed to bolus doses of Hg that collectively added up to nominally 200 µg Hg during the first 6 months of life. While several studies report an association between THI-containing vaccines and neurological disorders, other studies do not support the causal relation between THI and autism. With the purpose to understand the molecular mechanisms of the toxic effect of THI it was assayed on human red cells and in bilayers built-up of dimyristoylphosphatidylcholine (DMPC) and dimyristoylphosphatidylethanolamine (DMPE), classes of phospholipids found in the outer and inner monolayers of the human erythrocyte membrane, respectively...
December 2016: Journal of Membrane Biology
https://www.readbyqxmd.com/read/27695849/measles-and-measles-vaccination-a-review
#12
Johan Christiaan Bester
Importance: Measles is a highly communicable viral infection with serious complications. There have been continued outbreaks of measles in countries in which measles is considered to be eliminated, such as the United States and the Netherlands, and measles remains endemic in some countries. Health care professionals play an important role in diagnosing and managing acute cases of measles, preventing spread during outbreaks, and vaccination uptake. Objective: To provide an overview of measles and vaccination for health care professionals...
December 1, 2016: JAMA Pediatrics
https://www.readbyqxmd.com/read/27566772/a-model-to-estimate-the-impact-of-changes-in-mmr-vaccine-uptake-on-inequalities-in-measles-susceptibility-in-scotland
#13
Gary Napier, Duncan Lee, Chris Robertson, Andrew Lawson, Kevin G Pollock
An article published in 1998 by Andrew Wakefield in The Lancet (volume 351, pages 637-641) led to concerns surrounding the safety of the measles, mumps and rubella vaccine, by associating it with an increased risk of autism. The paper was later retracted after multiple epidemiological studies failed to find any association, but a substantial decrease in UK vaccination rates was observed in the years following publication. This paper proposes a novel spatio-temporal Bayesian hierarchical model with accompanying software (the R package CARBayesST) to simultaneously address three key epidemiological questions about vaccination rates: (i) what impact did the controversy have on the overall temporal trend in vaccination rates in Scotland; (ii) did the magnitude of the spatial inequality in measles susceptibility in Scotland increase due to the measles, mumps and rubella vaccination scare; and (iii) are there any covariate effects, such as deprivation, that impacted on measles susceptibility in Scotland...
August 2016: Statistical Methods in Medical Research
https://www.readbyqxmd.com/read/27531939/public-health-law-and-institutional-vaccine-skepticism
#14
Efthimios Parasidis
Vaccine-hesitant parents are often portrayed as misinformed dilettantes clinging to unscientific Internet chatter and a debunked study that linked vaccines and autism. While this depiction may be an accurate portrayal of a small (but vocal) subset, scholars have unearthed a more complex picture that casts vaccine hesitancy in the context of broader notions of lack of trust in government and industry. At the same time, commentators have highlighted limitations of the vaccine injury compensation program and US Supreme Court Justices Sonia Sotomayor and Ruth Bader Ginsburg have argued that preemption laws that provide vaccine manufacturers with broad legal immunities create "a regulatory vacuum in which no one ensures that vaccine manufacturers adequately take account of scientific and technological advancements when designing or distributing their products...
August 16, 2016: Journal of Health Politics, Policy and Law
https://www.readbyqxmd.com/read/27436570/-vaccination-counselling-the-meeting-point-is-possible
#15
Roi Piñeiro Pérez, Diego Hernández Martín, Miguel Ángel Carro Rodríguez, María de la Parte Cancho, Esther Casado Verrier, Sonsoles Galán Arévalo, Iván Carabaño Aguado
INTRODUCTION: There are recommendations for decision-making as regards parents who do not vaccinate their children, but there are few publications analysing this problem. In November 2014, a pioneer medical clinic opened in Spain, for counselling on immunisation practices. The aim of this study is to determine the success of the recommendations of the American and Spanish Paediatrics Associations according to the number of parents who finally accept vaccination. PATIENTS AND METHODS: A descriptive, cross-sectional, prospective and single-centre study was conducted from November 2014 to March 2016...
July 16, 2016: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/27196641/emotional-feedback-and-the-viral-spread-of-social-media-messages-about-autism-spectrum-disorders
#16
Christopher A Bail
OBJECTIVE: To determine whether exchanges of emotional language between health advocacy organizations and social media users predict the spread of posts about autism spectrum disorders (ASDs). METHODS: I created a Facebook application that tracked views of ASD advocacy organizations' posts between July 19, 2011, and December 18, 2012. I evaluated the association between exchanges of emotional language and viral views of posts, controlling for additional characteristics of posts, the organizations that produced them, the social media users who viewed them, and the broader social environment...
July 2016: American Journal of Public Health
https://www.readbyqxmd.com/read/27143072/-genotype-and-phenotype-of-female-dravet-syndrome-with-pcdh19-mutations
#17
A J Liu, Y H Zhang, X J Xu, X L Yang, Z X Yang, Y Wu, X Y Liu, Y W Jiang, X R Wu
OBJECTIVE: To explore the genotype and phenotype of female Dravet syndrome (DS) patients with PCDH19 mutations. METHOD: Clinical data of all DS patients seen at Pediatric Department of Peking University First Hospital from February 2005 to May 2015 were prospectively collected. Genomic DNAs were extracted from the patients and their family members. Female DS patients without SCN1A mutation were enrolled. PCR and Sanger sequencing were performed to identify PCDH19 mutations...
May 2016: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
https://www.readbyqxmd.com/read/27142139/the-future-of-neonatal-bcg
#18
Michel R Odent
We hypothesise that neonatal BCG (Bacillus Calmette-Guérin) might be used to adapt to a new phase in the history of human births. Among most mammals, the placenta is not effective at transferring antibodies to the fetus: antibodies are transferred immediately after birth via the colostrum. Among humans (and other mammals with hemochorial placentas) the transplacental transfer of antibodies (namely IgG) is effective. In humans, foetal concentrations of IgG sub-classes approximate to maternal concentrations at 38weeks and continue to increase thereafter...
June 2016: Medical Hypotheses
https://www.readbyqxmd.com/read/27076123/clinical-impact-of-vaccine-development
#19
Puja H Nambiar, Alejandro Delgado Daza, Lawrence L Livornese
The discovery and development of immunization has been a singular improvement in the health of mankind. This chapter reviews currently available vaccines, their historical development, and impact on public health. Specific mention is made in regard to the challenges and pursuit of a vaccine for the human immunodeficiency virus as well as the unfounded link between autism and measles vaccination.
2016: Methods in Molecular Biology
https://www.readbyqxmd.com/read/26945727/dose-response-analysis-indicating-time-dependent-neurotoxicity-caused-by-organic-and-inorganic-mercury-implications-for-toxic-effects-in-the-developing-brain
#20
REVIEW
Julia Pletz, Francisco Sánchez-Bayo, Henk A Tennekes
A latency period preceding neurotoxicity is a common characteristic in the dose-response relationship induced by organic mercury. Latency periods have typically been observed with genotoxicants in carcinogenesis, with cancer being manifested a long time after the initiating event. These observations indicate that even a very small dose may cause extensive adverse effects later in life, so the toxicity of the genotoxic compound is dose and time-dependent. In children, methylmercury exposure during pregnancy (in utero) has been associated with delays in reaching developmental milestones (e...
March 10, 2016: Toxicology
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