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histon actylation

Manabu Fuchikami, Shigeto Yamamoto, Shigeru Morinobu, Shiro Takei, Shigeto Yamawaki
Neuronal plasticity induced by changes in synaptic morphology and function is well known to play a pivotal role in leaning and memory as well as adaptation to stress. It is suggested that these plastic changes are due to orchestration of alterations in gene expression in the brain. Recent advances in molecular biology have provided evidence that epigenetic mechanisms, such as DNA methylation and histone modification, are crucial to gene transcription in the mammalian brain. Our research group has recently investigated the involvement of histone actylation at the promoter of the brain-derived neurotrophic factor (BDNF) gene in stress-induced reduction in BDNF, as well as in fear conditioning-induced enhancement of BDNF, in the rat hippocampus...
December 2010: Psychiatry Investigation
Arunan S Vamadevan, Masayuki Fukata, Elizabeth T Arnold, Lisa S Thomas, David Hsu, Maria T Abreu
The intestinal epithelium maintains a state of controlled inflammation despite continuous contact with Gram-negative commensal bacteria and lipopolysaccharide (LPS) on its luminal surface. Recognition of LPS by the Toll-like receptor (TLR) 4/MD-2 complex results in pro-inflammatory gene expression and cytokine secretion in intestinal epithelial cells (IECs). We have shown that IECs express low levels of MD-2 and TLR4 and are poorly responsive to LPS. In this study, we did a comprehensive analysis to understand the immune-mediated and epigenetic mechanisms by which IECs down-regulate MD-2 expression...
April 2010: Innate Immunity
K Narita
No abstract text is available yet for this article.
August 1965: Tanpakushitsu Kakusan Koso. Protein, Nucleic Acid, Enzyme
K Horiuchi, D Fujimoto
No abstract text is available yet for this article.
August 1972: Journal of Biochemistry
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