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https://www.readbyqxmd.com/read/27909499/hyperacute-and-chronic-changes-in-cerebral-magnetic-resonance-images-after-pvac-nmarq-and-epicardial-thoracoscopic-surgical-ablation-for-paroxysmal-atrial-fibrillation
#1
Conn Sugihara Mbbs, Neil Barlow Mbbs, Emma Owens Mbbs, David Sallomi Mb ChB, Neil Sulke Md
Threshold testing of cardiac rhythm devices is essential to monitoring the proper functioning of such devices (1). However, the currently method of applying multiple ECG leads to the patient is burdensome and time consuming (2). We are presenting a completely new way to perform cardiac rhythm device threshold testing using pulse oximetry. Twenty patients, with varying cardiac rhythm devices and pacing modes, were enrolled and had their atrial and ventricular thresholds tested. A comparison was made between simultaneous threshold determinations via the standard EGM based method and the new pulse oximetry based method...
April 2016: Journal of Atrial Fibrillation
https://www.readbyqxmd.com/read/27886968/defining-communication-improvement-needs-in-general-surgery-an-analysis-of-pages-communications-patterns-and-content%C3%A2
#2
Julie Hallet, David Wallace, Abraham El-Sedfy, Najma Ahmed, Andrew J Smith, Avery B Nathens, Lesley Gotlib Conn, Natalie G Coburn
OBJECTIVE: To describe patterns of pages communication to general surgery (GS) residents, identify the need for and develop strategies to improve interprofessional communication. DESIGN: Retrospective cohort study. SETTING: General surgery (GS) service at a tertiary care academic institution, Sunnybrook Health Sciences Centre, in Toronto, Ontario, Canada. PARTICIPANTS: All pages sent to GS residents over 4 weeks at an academic institution...
November 2016: Journal of Surgical Education
https://www.readbyqxmd.com/read/27835777/inflammatory-and-oxidative-stress-phenotypes-in-transgenic-sickle-cell-mice
#3
Emmanuelle Charrin, Solomon Fiifi Ofori-Acquah, Elie Nader, Sarah Skinner, Philippe Connes, Vincent Pialoux, Philippe Joly, Cyril Martin
The Townes mouse model of homozygous sickle cell disease (SS) has emerged as the major experimental model for studying pathophysiological mechanisms of human sickle cell disease (SCD). We therefore investigated hematological and hemorheological parameters as well as organ-specific inflammatory and oxidative stress molecular profiles in these animals in steady state conditions. Evidences of SCD-related intravascular hemolysis, impaired red blood cell (RBC) deformability, leukocytosis and altered plasma nitric oxide byproducts (NOx) level were found in the SS mice...
November 2016: Blood Cells, Molecules & Diseases
https://www.readbyqxmd.com/read/27801935/fluorescence-based-microplate-assays-for-in-vitro-assessment-of-mitochondrial-toxicity-metabolic-perturbation-and-cellular-oxygenation
#4
James Hynes, Conn Carey, Yvonne Will
High-throughput in vitro cell metabolism assays are of particular use for identification and delineation of mitochondrial toxicity and related metabolic perturbation. Here, a panel of fluorescence-based metabolism assays are described for measuring oxygen consumption, glycolytic flux, and cellular oxygenation. They can be applied to analysis of both isolated mitochondria and cell models. Sample data are presented illustrating how these protocols can be used to examine drug treatment, the interplay between oxidative and glycolytic ATP generation, and the impact of cell oxygenation on this balance...
November 1, 2016: Current Protocols in Toxicology
https://www.readbyqxmd.com/read/27799639/epidemiology-of-plasmodium-vivax-malaria-in-peru
#5
Angel Rosas-Aguirre, Dionicia Gamboa, Paulo Manrique, Jan E Conn, Marta Moreno, Andres G Lescano, Juan F Sanchez, Hugo Rodriguez, Hermann Silva, Alejandro Llanos-Cuentas, Joseph M Vinetz
Malaria in Peru, dominated by Plasmodium vivax, remains a public health problem. The 1990s saw newly epidemic malaria emerge, primarily in the Loreto Department in the Amazon region, including areas near to Iquitos, the capital city, but sporadic malaria transmission also occurred in the 1990s-2000s in both north-coastal Peru and the gold mining regions of southeastern Peru. Although a Global Fund-supported intervention (PAMAFRO, 2005-2010) was temporally associated with a decrease of malaria transmission, from 2012 to the present, both P...
October 31, 2016: American Journal of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/27777260/insight-into-the-rna-exosome-complex-through-modeling-pontocerebellar-hypoplasia-type-1b-disease-mutations-in-yeast
#6
Milo B Fasken, Jillian S Losh, Sara W Leung, Sergine Brutus, Brittany Avin, Jillian C Vaught, Jennifer Potter-Birriel, Taylor Craig, Graeme L Conn, Katherine Mills-Lujan, Anita H Corbett, Ambro van Hoof
Pontocerebellar Hypoplasia type 1b (PCH1b) is an autosomal recessive disorder that causes cerebellar hypoplasia and spinal motor neuron degeneration leading to mortality in early childhood. PCH1b is caused by mutations in the RNA exosome subunit gene, EXOSC3 The RNA exosome is an evolutionarily conserved complex, consisting of nine different core subunits and one or two 3'-5' exoribonuclease subunits, that mediates several RNA degradation and processing steps. The goal of this study is to assess the functional consequences of the amino acid substitutions that have been identified in EXOSC3 in PCH1b patients...
October 24, 2016: Genetics
https://www.readbyqxmd.com/read/27773752/a-stimuli-responsive-liposome-loaded-hydrogel-provides-flexible-on-demand-release-of-therapeutic-agents
#7
Hugh S O'Neill, Caroline C Herron, Conn L Hastings, Roel Deckers, Adolfo Lopez Noriega, Helena M Kelly, Wim E Hennink, Ciarán O McDonnell, Fergal J O'Brien, Eduardo Ruiz-Hernández, Garry P Duffy
Lysolipid-based thermosensitive liposomes (LTSL) embedded in a chitosan-based thermoresponsive hydrogel matrix (denoted Lipogel) represents a novel approach for the spatiotemporal release of therapeutic agents. The entrapment of drug-loaded liposomes in an injectable hydrogel permits local liposome retention, thus providing a prolonged release in target tissues. Moreover, release can be controlled through the use of a minimally invasive external hyperthermic stimulus. Temporal control of release is particularly important for complex multi-step physiological processes, such as angiogenesis, in which different signals are required at different times in order to produce a robust vasculature...
October 20, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27768005/the-effects-of-labisia-pumila-extracts-on-bone-microarchitecture-of-ovariectomized-induced-osteoporosis-rats-a-micro-ct-analysis
#8
Nadia Mohd Effendy, Mohd Fadhli Khamis, Ahmad Nazrun Shuid
BACKGOUND: Labisia pumila (LP) is a popular herb used by women over the past few decades. This herb has shown potentials as an alternative agent for treatment and prevention of postmenopausal osteoporosis. It was observed in previous studies that supplementation to ovariectomized rats were associated with increased bone antioxidative enzymes and reduced lipid peroxidation activity. It had also improved bone formation markers in ovariectomized rats. This study aimed to evaluate the effects of giving different forms of LP extracts on the trabecular bone microarchitecture of ovariectomised rats...
October 21, 2016: Journal of X-ray Science and Technology
https://www.readbyqxmd.com/read/27750372/copy-number-gain-of-11q13-3-genes-associates-with-pathological-stage-in-hypopharyngeal-squamous-cell-carcinoma
#9
Samuel B Pattle, Natasa Utjesanovic, Athena Togo, Lucy Wells, Brendan Conn, Hannah Monaghan, Elizabeth Junor, Ingolfur Johannessen, Kate Cuschieri, Simon Talbot
Squamous cell carcinomas of the hypopharynx (HPSCC) and oropharynx (OPSCC) have markedly different patient outcomes. Differences in HPV prevalence between these two patient groups may account for some of this difference, but other molecular markers of prognosis or pathological phenotype have not been established. Copy number gain of oncogenes is a well-established molecular change contributing to HNSCC development. Quantitative PCR was used to explore copy number gains of specific genes (3q-PIK3CA, TP63; 11q13...
October 17, 2016: Genes, Chromosomes & Cancer
https://www.readbyqxmd.com/read/27743835/sclerosing-odontogenic-carcinoma-presenting-on-the-hard-palate-of-a-43-year-old-female-a-case-report
#10
Andrew Wood, Fiona Young, James Morrison, Brendon I Conn
We present a case of sclerosing odontogenic carcinoma (SOC) occurring on the hard palate of a 43-year-old female. The tumor presented as an asymptomatic firm swelling and histopathologically was characterized by widely dispersed nests and cords of bland cells infiltrating between hyalinized collagen fibers. Prominent perineural and intraneural invasion and erosion of bone was noted. The tumor cells showed staining with antibodies to pan-cytokeratin (PanCK), cytokeratin 19 (CK19), cytokeratin 5/6 (CK5/6), cytokeratin 14 (CK14), p63 and E-cadherin, but no staining with antibodies to carcinoembryonic antigen (CEA), cytokeratin 7 (CK7), cytokeratin 20 (CK20), estrogen receptor (ER), progesterone receptor (PR) or S100...
December 2016: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
https://www.readbyqxmd.com/read/27734165/medication-adherence-in-patients-with-myotonic-dystrophy-and-facioscapulohumeral-muscular-dystrophy
#11
Bryan P Fitzgerald, Kelly M Conn, Joanne Smith, Andrew Walker, Amy L Parkhill, James E Hilbert, Elizabeth A Luebbe, Richard T Moxley Iii
Myotonic dystrophy (DM) and facioscapulohumeral muscular dystrophy (FSHD) are the two most common adult muscular dystrophies and have progressive and often disabling manifestations. Higher levels of medication adherence lead to better health outcomes, especially important to patients with DM and FSHD because of their multisystem manifestations and complexity of care. However, medication adherence has not previously been studied in a large cohort of DM type 1 (DM1), DM type 2 (DM2), and FSHD patients. The purpose of our study was to survey medication adherence and disease manifestations in patients enrolled in the NIH-supported National DM and FSHD Registry...
December 2016: Journal of Neurology
https://www.readbyqxmd.com/read/27708073/exploring-path-models-of-disablement-in-residential-care-and-assisted-living-residents
#12
Lorraine J Phillips, Gregory F Petroski, Vicki S Conn, Marybeth Brown, Emily Leary, Linda Teri, Sheryl Zimmerman
This study examined the relationships between individual and environmental factors and physical activity, and between physical activity and functional limitations and disability in residential care/assisted living (RC/AL) residents. Participants completed questionnaires and physical performance tests, and wore the Fitbit Motion Tracker® to capture physical activity. Model fit was analyzed using two-level path models with residents nested within RC/AL settings. Model parameters were estimated using the MPlus robust maximum likelihood method...
October 4, 2016: Journal of Applied Gerontology: the Official Journal of the Southern Gerontological Society
https://www.readbyqxmd.com/read/27669296/providing-flaxseed-oil-but-not-menhaden-oil-protects-against-ovx-induced-bone-loss-in-the-mandible-of-sprague-dawley-rats
#13
Amanda B Longo, Wendy E Ward
Higher intakes of polyunsaturated fatty acids (PUFA) are associated with benefits at several skeletal sites in postmenopausal women and in rodent models, but the effect of PUFA-containing oils on tooth-supporting alveolar bone of the mandible has not been studied. Moreover, direct comparison of the effect of flaxseed oil (a source of alpha-linolenic acid (ALA)) and menhaden oil (a source of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)) is unknown. One-month old female Sprague-Dawley rats (n = 48) were randomized to and fed a diet containing flaxseed oil or menhaden oil from one to six months of age...
2016: Nutrients
https://www.readbyqxmd.com/read/27618677/antipsychotic-like-effects-of-m4-positive-allosteric-modulators-are-mediated-by-cb2-receptor-dependent-inhibition-of-dopamine-release
#14
Daniel J Foster, Jermaine M Wilson, Daniel H Remke, M Suhaib Mahmood, M Jashim Uddin, Jürgen Wess, Sachin Patel, Lawrence J Marnett, Colleen M Niswender, Carrie K Jones, Zixiu Xiang, Craig W Lindsley, Jerri M Rook, P Jeffrey Conn
Muscarinic receptors represent a promising therapeutic target for schizophrenia, but the mechanisms underlying the antipsychotic efficacy of muscarinic modulators are not well understood. Here, we report that activation of M4 receptors on striatal spiny projection neurons results in a novel form of dopaminergic regulation resulting in a sustained depression of striatal dopamine release that is observed more than 30 min after removal of the muscarinic receptor agonist. Furthermore, both the M4-mediated sustained inhibition of dopamine release and the antipsychotic-like efficacy of M4 activators were found to require intact signaling through CB2 cannabinoid receptors...
September 21, 2016: Neuron
https://www.readbyqxmd.com/read/27617634/prefrontal-cortex-mediated-impairments-in-a-genetic-model-of-nmda-receptor-hypofunction-are-reversed-by-the-novel-m1-pam-vu6004256
#15
Michael D Grannan, Catharine A Mielnik, Sean P Moran, Robert W Gould, Jacob Ball, Zhuoyan Lu, Michael Bubser, Amy J Ramsey, Masahito Abe, Hyekyung P Cho, Kellie D Nance, Anna L Blobaum, Colleen M Niswender, P Jeffrey Conn, Craig W Lindsley, Carrie K Jones
Abnormalities in the signaling of the N-methyl-d-aspartate subtype of the glutamate receptor (NMDAR) within cortical and limbic brain regions are thought to underlie many of the complex cognitive and affective symptoms observed in individuals with schizophrenia. The M1 muscarinic acetylcholine receptor (mAChR) subtype is a closely coupled signaling partner of the NMDAR. Accumulating evidence suggests that development of selective positive allosteric modulators (PAMs) of the M1 receptor represent an important treatment strategy for the potential normalization of disruptions in NMDAR signaling in patients with schizophrenia...
October 5, 2016: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/27599986/optimizing-bariatric-surgery-multidisciplinary-follow-up-a-focus-on-patient-centered-care
#16
Mary-Anne Aarts, Nardhana Sivapalan, Seyed-Ehsan Nikzad, Kristin Serodio, Sanjeev Sockalingam, Lesley Gotlib Conn
BACKGROUND: Failure to follow-up post-bariatric surgery has been associated with higher postoperative complications, lower percentage weight loss and poorer nutrition. OBJECTIVE: This study aimed to understand the patient follow-up experience in order to optimize follow-up care within a comprehensive bariatric surgery program. METHODS: Qualitative telephone interviews were conducted in patients who underwent surgery through a publically funded multidisciplinary bariatric surgery program in 2011, in Ontario, Canada...
September 7, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/27575707/an-essential-viral-transcription-activator-modulates-chromatin-dynamics
#17
Rebecca L Gibeault, Kristen L Conn, Michael D Bildersheim, Luis M Schang
Although ICP4 is the only essential transcription activator of herpes simplex virus 1 (HSV-1), its mechanisms of action are still only partially understood. We and others propose a model in which HSV-1 genomes are chromatinized as a cellular defense to inhibit HSV-1 transcription. To counteract silencing, HSV-1 would have evolved proteins that prevent or destabilize chromatinization to activate transcription. These proteins should act as HSV-1 transcription activators. We have shown that HSV-1 genomes are organized in highly dynamic nucleosomes and that histone dynamics increase in cells infected with wild type HSV-1...
August 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27567787/don-t-forget-time-in-environmental-design1
#18
C Bazley, P Vink
This paper discusses the importance of including time in environmental design and the challenges facing environmental design now and in the future. Research shows that important factors for studying the effects of environments are time, body movement, control and sensory variability. There are many ways to incorporate time into the design and it is dependent on the type of environmental design. Research also suggests that discomfort in restrictive environments, e.g., in an airplane or automobile are strongly related long periods of inactivity and lack of sensory stimulation...
August 12, 2016: Work: a Journal of Prevention, Assessment, and Rehabilitation
https://www.readbyqxmd.com/read/27559474/improving-physical-health-monitoring-for-patients-with-chronic-mental-health-problems-who-receive-antipsychotic-medications
#19
Nihad Abdallah, Rory Conn, Abdel Latif Marini
Physical health monitoring is an integral part of caring for patients with mental health problems. It is proven that serious physical health problems are more common among patients with severe mental health illness (SMI), this monitoring can be challenging and there is a need for improvement. The project aimed at improving the physical health monitoring among patients with SMI who are receiving antipsychotic medications. The improvement process focused on ensuring there is a good communication with general practitioners (GPs) as well as patient's education and education of care home staff...
2016: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/27511762/when-co-authors-are-missing-in-action
#20
EDITORIAL
Vicki S Conn, Janet S Carpenter, Carol Estwing Ferrans, Janet L Larson, Ann Marie McCarthy
No abstract text is available yet for this article.
September 2016: Western Journal of Nursing Research
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