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antidiabetic drug research

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https://www.readbyqxmd.com/read/29305899/a-role-of-ficus-species-in-the-management-of-diabetes-mellitus-a-review
#1
REVIEW
Ponnuvel Deepa, Kandhasamy Sowndhararajan, Songmun Kim, Se Jin Park
ETHNOPHARMACOLOGICAL RELEVANCE: Diabetes mellitus is one of the most common global health concerns, with a rapidly increasing incidence. A variety of medicinal plants, particularly those belonging to the genus Ficus (Moraceae), and their active compounds have been used to treat diabetes and related chronic disorders since ancient times. AIM OF THE STUDY: The aim of this review is to provide information regarding traditional and scientific knowledge of Ficus species with antidiabetic activity to researchers...
January 3, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29288945/recent-advance-in-oxazole-based-medicinal-chemistry
#2
REVIEW
Hui-Zhen Zhang, Zhi-Long Zhao, Cheng-He Zhou
Oxazole compounds containing nitrogen and oxygen atoms in the five-membered aromatic ring are readily able to bind with a variety of enzymes and receptors in biological systems via diverse non-covalent interactions, and thus display versatile biological activities. The related researches in oxazole-based derivatives including oxazoles, isoxazoles, oxazolines, oxadiazoles, oxazolidones, benzoxazoles and so on, as medicinal drugs have been an extremely active topic, and numerous excellent achievements have been acquired...
December 14, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29283894/incretin-based-drugs-and-the-incidence-of-colorectal-cancer-in-patients-with-type-2-diabetes
#3
Devin Abrahami, Hui Yin, Oriana H Y Yu, Michael N Pollak, Laurent Azoulay
BACKGROUND: Evidence on the safety of the incretin-based drugs (glucagon-like peptide-1 [GLP-1] analogues and dipeptidyl peptidase-4 [DPP-4] inhibitors) with respect to colorectal cancer is contradictory. The objective of this study was to determine whether use of incretin-based drugs is associated with risk of incident colorectal cancer in patients with type 2 diabetes. METHODS: Using data from the United Kingdom Clinical Practice Research Datalink, we identified a cohort of 112,040 patients newly treated with antidiabetic drugs between 1 January 2007 and 31 March 2015...
December 26, 2017: Epidemiology
https://www.readbyqxmd.com/read/29278204/looking-for-new-antifungal-drugs-from-flavonoids-impact-of-the-genetic-diversity-of-candida-albicans-on-the-in-vitro-response
#4
Maria Rosa Felice, Letterio Giuffre, Lamya El Aamri, Majida Hafidi, Giuseppe Criseo, Orazio Romeo, Fabio Scordino
In an era in which antimicrobial resistance is increasing at an alarming pace, it's very important to find new antimicrobial agents effective against pathogenic microrganisms resistant to traditional treatments. Among the notable breakthroughs in the past years of research in natural-drug discovery there is the identification and testing of flavonoids, a group of plant-derived substances capable of promoting many beneficial effects on humans. These compounds show different biological activities such as inhibition of neuroinflammation and tumor growth as well as antidepressant, antiarthritic, anti-hypercholesterolemic, antidiabetic, antiulcer and antiasthmatic activities...
December 25, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29230104/metformin-sensitizes-non-small-cell-lung-cancer-cells-to-an-epigallocatechin-3-gallate-egcg-treatment-by-suppressing-the-nrf2-ho-1-signaling-pathway
#5
Chenxiao Yu, Yang Jiao, Jiao Xue, Qi Zhang, Hongying Yang, Ligang Xing, Guangxia Chen, Jinchang Wu, Shuyu Zhang, Wei Zhu, Jianping Cao
Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. (-)-Epigallocatechin-3-gallate (EGCG), a major polyphenol in green tea, is widely studied as a cancer chemopreventive agent with potential anti-cancer effects. The NF-E2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1) signaling pathway is considered to mediate cellular resistance to EGCG. Metformin, a classical antidiabetic drug, has been shown to prevent cancer progression. Researchers have not reported whether metformin potentiates the anti-cancer efficacy of EGCG...
2017: International Journal of Biological Sciences
https://www.readbyqxmd.com/read/29227526/bioactive-peptides-derived-from-seaweed-protein-and-their-health-benefits-antihypertensive-antioxidant-and-antidiabetic-properties
#6
REVIEW
Habtamu Admassu, Mohammed Abdalbasit A Gasmalla, Ruijin Yang, Wei Zhao
Cardiovascular diseases and diabetes are the biggest causes of death globally. Therefore, prevention of these diseases is a focus of pharmaceuticals and functional food manufacturers. This review summarizes recent research trends and scientific knowledge in seaweed protein-derived peptides with particular emphasis on production, isolation and potential health impacts in prevention of hypertension, diabetes and oxidative stress. The current status and future prospects of bioactive peptides are also discussed...
December 11, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/29221645/primary-care-led-weight-management-for-remission-of-type-2-diabetes-direct-an-open-label-cluster-randomised-trial
#7
Michael Ej Lean, Wilma S Leslie, Alison C Barnes, Naomi Brosnahan, George Thom, Louise McCombie, Carl Peters, Sviatlana Zhyzhneuskaya, Ahmad Al-Mrabeh, Kieren G Hollingsworth, Angela M Rodrigues, Lucia Rehackova, Ashley J Adamson, Falko F Sniehotta, John C Mathers, Hazel M Ross, Yvonne McIlvenna, Renae Stefanetti, Michael Trenell, Paul Welsh, Sharon Kean, Ian Ford, Alex McConnachie, Naveed Sattar, Roy Taylor
BACKGROUND: Type 2 diabetes is a chronic disorder that requires lifelong treatment. We aimed to assess whether intensive weight management within routine primary care would achieve remission of type 2 diabetes. METHODS: We did this open-label, cluster-randomised trial (DiRECT) at 49 primary care practices in Scotland and the Tyneside region of England. Practices were randomly assigned (1:1), via a computer-generated list, to provide either a weight management programme (intervention) or best-practice care by guidelines (control), with stratification for study site (Tyneside or Scotland) and practice list size (>5700 or ≤5700)...
December 4, 2017: Lancet
https://www.readbyqxmd.com/read/29212337/-status-of-pharmacotherapy-in-current-care-of-obese
#8
Petr Sucharda
Weight loss drugs or anti-obesity drugs have a long history but are still far from being successful. Only in two last decades have the drugs been launched, which, when appropriately indicated, may be significantly beneficial to patients in need of weight loss as they are comparably effective to intensive programs to promote changes in eating habits and lifestyles. The combination naltrexone/bupropion is promising for food intake control including the reward mechanism, but the experience with its use has only been short-term...
2017: Casopís Lékar̆ů C̆eských
https://www.readbyqxmd.com/read/29210642/antidiabetics-structural-diversity-of-molecules-with-a-common-aim
#9
Jelena B Popovic-Dordevic, Ivana I Jevtic, Tatjana P Stanojkovic
BACKGROUND: Diabetes mellitus type 2 (DMT2) is an endocrine disease of global proportions which is currently affecting 1 in 12 adults in the world, with still increasing prevalence. World Health Organization (WHO) declared this worldwide health problem, as an epidemic disease, to be the only non-infectious disease with such categorization. People with DMT2 are at increased risk of various complications and have shorter life expectancy. The main classes of oral antidiabetic drugs accessible today for DMT2 vary in their chemical composition, modes of action, safety profiles and tolerability...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29210637/metallopharmaceuticals-in-therapy-a-new-horizon-for-scientific-research
#10
Agnieszka Chylewska, Małgorzata Biedulska, Przemyslaw Sumczynski, Mariusz Makowski
Coordination chemistry offers much scope for the design of novel and therapeutic agents, including metallopharmaceuticals. The widespread use of metal complexes as effective pharmaceuticals, e.g. cancer therapeutic, anti-inflammatory, antidiabetic drugs or antimicrobial and diagnostic agents, demonstrates that the cytotoxicity of metal ions can be finely controlled via the appropriate choice of ligands. The successful targeting of radioisotopes again depends on the ligand design and metal oxidation state. The complexes of platinum, ruthenium, cobalt, copper and other d-block metal ions have been used in medicine for a long time but only recent advances have been made in understanding the molecular basis of mechanism of their action...
December 5, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29196903/concurrent-use-of-prescription-drugs-and-herbal-medicinal-products-in-older-adults-a-systematic-review
#11
REVIEW
Taofikat B Agbabiaka, Barbara Wider, Leala K Watson, Claire Goodman
BACKGROUND: The use of herbal medicinal products (HMPs) is common among older adults; however, little is known about concurrent use with prescription drugs, as well as potential interactions associated with such combinations. OBJECTIVE: The aim of this systematic review was to identify and evaluate the literature on concurrent prescription and HMP use among older adults to assess prevalence, patterns, potential interactions and factors associated with this use. METHODS: Systematic searches were conducted in the MEDLINE, PsycINFO, EMBASE, CINAHL, AMED, Web of Science and Cochrane databases from inception to May 2017 for studies reporting concurrent use of prescription medicines with HMPs in adults ≥ 65 years of age...
December 1, 2017: Drugs & Aging
https://www.readbyqxmd.com/read/29171906/risk-of-a-first-ever-acute-myocardial-infarction-and-all-cause-mortality-with-sulphonylurea-treatment-a-population-based-cohort-study
#12
Judith van Dalem, Martijn C G J Brouwers, Coen D A Stehouwer, André Krings, Olaf H Klungel, Johanna H M Driessen, Frank de Vries, Andrea M Burden
We investigated the association between the current use of individual sulphonylureas and the risk of a first-ever acute myocardial infarction (AMI) and all-cause mortality, in a population-based cohort study, using primary care data from the Clinical Practice Research Datalink database (2004-2012). New users (N = 121 869), aged ≥18 years, with at least one prescription for a non-insulin antidiabetic agent were included. The first prescription defined start of follow-up. Time-dependent Cox proportional hazard models were used to estimate the risk of a first-ever AMI and all-cause mortality associated with the use of individual sulphonylureas, and other non-insulin glucose-lowering drugs...
November 24, 2017: Diabetes, Obesity & Metabolism
https://www.readbyqxmd.com/read/29155174/ethnopharmacology-phytochemistry-and-pharmacology-of-cornus-officinalis-sieb-et-zucc
#13
REVIEW
Jun Huang, Yiwei Zhang, Lin Dong, Qinghan Gao, Lei Yin, Hongfeng Quan, Rong Chen, Xueyan Fu, Dingbo Lin
ETHNOPHARMACOLOGICAL RELEVANCE: Cornus officinalis (Cornaceae), known in Chinese as "Shanzhuyu," is a frequently used traditional Chinese medicine. It tastes sour and is astringent and slightly warm in nature. Its fruits have long been used to treat kidney deficiency, high blood pressure, waist and knee pain, dizziness, tinnitus, impotence, spermatorrhea, menorrhagia, and other diseases in China. The main distribution areas are Shanxi and Gansu. AIM OF THE STUDY: This review focused on the ethnopharmacological uses of the herb...
November 17, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29144162/association-between-metformin-adherence-and-all-cause-mortality-among-new-users-of-metformin-a-nested-case-control-study
#14
Patrice Simard, Nancy Presse, Louise Roy, Marc Dorais, Brian White-Guay, Agnès Räkel, Sylvie Perreault
BACKGROUND: Metformin presents better survival rates than other oral antidiabetics in the treatment of type 2 diabetes. However, these benefits may be dampened by inadequate treatment adherence. OBJECTIVE: We aimed to investigate the relationship between adherence level to metformin therapy and all-cause mortality over 10 years in incident metformin users. METHODS: A nested case-control study was conducted using a large cohort of beneficiaries of the Quebec public drug insurance plan, aged 45 to 85 years, who initiated metformin between 2000 and 2009...
November 1, 2017: Annals of Pharmacotherapy
https://www.readbyqxmd.com/read/29114561/awareness-about-rational-use-of-medicines-among-fresh-bachelor-of-medicine-and-bachelor-of-surgery-graduates
#15
Vijaya Laxman Chaudhari, Smita N Mali, Amruta V Dawari, Tushar B Nishandar
CONTEXT: Fresh Bachelor of Medicine and Bachelor of Surgery graduates (FMGs) are responsible for the majority of prescription errors and irrational use of medicines. Little research has explored their knowledge on rational prescribing practices. AIMS: The present study aimed to evaluate the awareness of rational use of medicines (RUMs) among the FMGs. SETTINGS AND DESIGN: A multicentric, cross-sectional, and questionnaire-based study was conducted among 308 FMGs during the internship orientation program...
2017: Journal of Education and Health Promotion
https://www.readbyqxmd.com/read/29090668/antimicrobial-potential-of-benzimidazole-derived-molecules
#16
Yogita Bansal, Manjinder Kaur, Gulshan Bansal
Structural resemblance of benzimidazole nucleus with purine nucleus in nucleotides makes benzimidazole derivatives attractive ligands to interact with biopolymers of a living system. The most prominent benzimidazole compound in nature is N-ribosyldimethylbenzimidazole, which serves as an axial ligand for cobalt in vitamin B12. This structural similarity prompted medicinal chemists across the globe to synthesize a variety of benzimidazole derivatives and to screen those for various biological activities, such as anticancer, hormone antagonist, antiviral, anti-HIV, anthelmintic, antiprotozoal, antimicrobial, antihypertensive, anti-inflammatory, analgesic, anxiolytic, antiallergic, coagulant, anticoagulant, antioxidant and antidiabetic activities...
October 31, 2017: Mini Reviews in Medicinal Chemistry
https://www.readbyqxmd.com/read/29076039/effect-of-trelagliptin-on-quality-of-life-in-patients-with-type-2-diabetes-mellitus-study-protocol
#17
Hitoshi Ishii, Yuki Suzaki, Yuko Miyata
INTRODUCTION: Long-term glycemic control in type 2 diabetes is critical to prevent or delay the onset of macrovascular and microvascular complications. Medication adherence is an integral component of type 2 diabetes management. Minimizing the dosing frequency of antidiabetic drugs may reduce treatment burden for patients and improve medication adherence. This study has been proposed to assess the reduction in treatment burden during 12 weeks' administration of trelagliptin, a weekly dosing dipeptidyl peptidase-4 (DPP-4) inhibitor, compared with a daily dosing DPP-4 inhibitor in patients with type 2 diabetes...
December 2017: Diabetes Therapy: Research, Treatment and Education of Diabetes and related Disorders
https://www.readbyqxmd.com/read/29068991/the-prescribing-trend-of-oral-antidiabetic-agents-for-type-2-diabetes-in-taiwan-an-8-year-population-based-study
#18
Wei-Min Chu, Hsin-En Ho, Kuang-Hua Huang, Yu-Tse Tsan, Yi-Sheng Liou, Yueh-Hsin Wang, Meng-Chih Lee, Yu-Ching Li
The purpose of this study was to evaluate the prescription trend and pattern of oral antidiabetic (OAD) medications, which are extensively used worldwide for treating type 2 diabetes, in 2 age groups.In this population-based study, data obtained from the National Health Insurance Research Database, Taiwan, were analyzed to investigate the prescription trend of all types of OAD medications during 2005 to 2012. We used descriptive statistics to demonstrate the trend of prescription patterns stratified by age (aged 65 years and above or younger than 65)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29055800/anti-diabetic-potential-of-peptides-future-prospects-as-therapeutic-agents
#19
REVIEW
Marya, Haroon Khan, Seyed Mohammad Nabvi, Solomon Habtemariam
Diabetes mellitus is a metabolic disorder in which the glucose level in blood exceeds beyond the normal level and its effective control is recognized as a global challenge for clinician. Persistent hyperglycemia leads to diabetes late complication and obviously account for a large number of morbidity and mortality worldwide. Numerous therapeutic options are available for the treatment of diabetes including insulin for type I and oral tablets for type II, but its effective management is still a dream. Several options are under investigation in various research laboratories for efficacious and safer agents...
October 18, 2017: Life Sciences
https://www.readbyqxmd.com/read/29032756/antidiabetic-drugs-as-antihypertensives-new-data-on-the-horizon
#20
Vassiliki Mamakou, Ioanna Eleftheriadou, Niki Katsiki, Konstantinos Makrilakis, Konstantinos Tsioufis, Nikoalos Tentolouris
The prevalence of type 2 diabetes mellitus (T2DM) increases worldwide, forcing for more research in the area of the optimal diabetes management. Cardiovascular disease (CVD) remains the commonest cause of death in individuals with T2DM. Besides hyperglycemia, an explanation for the increased mortality in this population is the increased prevalence of comorbidities, such as hypertension and dyslipidemia. Recent population-based studies described a prevalence of hypertension greater than 80% in patients with T2DM...
October 10, 2017: Current Vascular Pharmacology
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