Q-X Li, X Ao, L Wen, H-J Zhong, X-Y Zeng, Y Li, H-R Gong, J-X Li, Q Wu, Z Zhang, X-K Peng, J-X Zhang, S-Y Yuan, A-M Zhu, G Li, Y Zhang, Q-X Meng
BACKGROUND: We used recombinant adeno-associated virus vector of adiponectin (AAV2/1-Acrp30) to study the effects of increased levels of adioponectin (by the administration of rAAV2/1-Acrp30) on arteriosclerosis, glucose and lipid metabolism in Goto-Kakizaki (GK) rats with arteriosclerosis. METHODS: Thirty GK rats with arteriosclerosis were divided into 3 equal groups: control group 1, control group 2 and the rAAV2/1-Acrp30-administered group. Saline, virus vector or rAAV2/1-Acrp30 (10 12 ng/ml) vector genomes administered to the rats in the corresponding group by intramuscular injection to the posterior limb by single administration, respectively...
January 2012: National Medical Journal of India