Read by QxMD icon Read


Koji Takemoto, Richard J Deckelbaum, Isao Saito, Supawadee Likitmaskul, Anita Morandi, Leonardo Pinelli, Eiichi Ishii, Kaichi Kida, Marwah Abdalla
BACKGROUND: There are few reports on the effects of ethnicity or gender in the association between adipocytokines and insulin resistance in children of different ages. This study assessed associations between serum concentrations of adiponectin/resistin and parameters of insulin resistance in children from 4 different countries. METHODS: A total of 2,290 children were analyzed in this study; each was from one of 4 different countries (Japan, Thailand, Italy and USA), and grouped according to age (8-11 years old in Group 1 and 12-15 years old in Group 2)...
2015: International Journal of Pediatric Endocrinology
Jillian Ashley-Martin, Linda Dodds, Tye E Arbuckle, Adrienne S Ettinger, Gabriel D Shapiro, Mandy Fisher, Anne-Sophie Morisset, Shayne Taback, Maryse F Bouchard, Patricia Monnier, Renee Dallaire, William D Fraser
BACKGROUND: Obesity and type-2 diabetes are on the rise and in utero exposure to environmental contaminants is a suspected contributing factor. Our objective was to examine associations between prenatal exposure to potential endocrine disrupting chemicals and markers of fetal metabolic dysfunction. METHODS: The Maternal-Infant Research on Environmental Chemicals Study (MIREC) recruited 2001 women during the first trimester of pregnancy from 10 Canadian sites. First trimester maternal urine was measured for 11 phthalate metabolites and bisphenol A (BPA)...
2014: Environmental Health: a Global Access Science Source
Chuan Dong Wei, Yan Li, Hong Yun Zheng, Kai Sheng Sun, Yong Qing Tong, Wen Dai, Wei Wu, An Yu Bao
UNLABELLED: Cardiomyocytes apoptosis is an important contributor to myocardial dysfunction and heart failure. Adiponectin has cardioprotective effects, potential mechanisms behind it are not clear in cardiomyocytes. The purpose of the study was to investigate whether adiponectin can block palmitate-induced apoptosis and the underlying biochemical mechanism in H9c2 cells. METHODS: H9c2 cells were treated with palmitate presence or absence of 2.5 μg/mL globular adiponectin...
October 11, 2012: Lipids in Health and Disease
Q-X Li, X Ao, L Wen, H-J Zhong, X-Y Zeng, Y Li, H-R Gong, J-X Li, Q Wu, Z Zhang, X-K Peng, J-X Zhang, S-Y Yuan, A-M Zhu, G Li, Y Zhang, Q-X Meng
BACKGROUND: We used recombinant adeno-associated virus vector of adiponectin (AAV2/1-Acrp30) to study the effects of increased levels of adioponectin (by the administration of rAAV2/1-Acrp30) on arteriosclerosis, glucose and lipid metabolism in Goto-Kakizaki (GK) rats with arteriosclerosis. METHODS: Thirty GK rats with arteriosclerosis were divided into 3 equal groups: control group 1, control group 2 and the rAAV2/1-Acrp30-administered group. Saline, virus vector or rAAV2/1-Acrp30 (10 12 ng/ml) vector genomes administered to the rats in the corresponding group by intramuscular injection to the posterior limb by single administration, respectively...
January 2012: National Medical Journal of India
Yumi Tsuruta, Koji Nagao, Bungo Shirouchi, Saori Nomura, Keisuke Tsuge, Kazuyoshi Koganemaru, Teruyoshi Yanagita
Non-alcoholic fatty liver disease (NAFLD) is emerging as the most common liver disease in industrialized countries. The discovery of food components that would ameliorate NAFLD is therefore of interest. Lotus root, the edible rhizome of Nelumbo nucifera, contains a high level of polyphenolic compounds, and several health-promoting properties of lotus root have been reported. The present study examines whether dietary lotus root powder can protect db/db mice from hepatic injury. After 3 weeks of feeding, the hepatomegaly, hepatic triglyceride accumulation, and elevated hepatic injury markers in the serum were markedly alleviated in the Lotus diet-fed db/db mice relative to the control mice...
2012: Bioscience, Biotechnology, and Biochemistry
Jong Suk Park, Min Ho Cho, Ji Sun Nam, Jeong Seon Yoo, Chul Woo Ahn, Bong Soo Cha, Kyung Rae Kim, Hyun Chul Lee
OBJECTIVE: Osteoprotegerin (OPG) acts as an important regulatory molecule in atherosclerosis. Recent studies report that thiazolidinediones could affect OPG expression. We investigated the relationship between OPG and inflammatory cytokines and the effects of pioglitazone (a PPARγ (PPARG) agonist) versus metformin on serum OPG levels in type 2 diabetic patients. DESIGN AND METHODS: Sixty-seven type 2 diabetic patients were included in this study. They were assigned to pioglitazone (15 mg/day, n=34) or metformin (1000 mg/day, n=33) during 24 weeks...
January 2011: European Journal of Endocrinology
Jian-Hua Shi, Wen-Hua Du, Xiao-Yan Liu, Yan-Ping Fan, Xiao-Lei Hu, Hai-Yan Zhou, Huan-Bai Xu, Xiao-Mei Zhang, Ping Xiang, Feng-Ling Chen
OBJECTIVE: Accumulating evidence suggests that adiponectin plays an important role in the genesis of obesity and insulin resistance. Although it has been shown that glucocortocoids (GC) inhibit adiponectin expression in vitro, there exist discrepant results in vivo. In this study, we observe the effect of GC on the serum adiponectin level and adiponectin expression in white adipose tissue (WAT) in male SD rats. METHODS: An obese rat model was made by a high-fat diet...
December 2010: Steroids
Teru Nada, Masahiro Nomura, Kunihiko Koshiba, Tomohito Kawano, Jyunichi Mikawa, Susumu Ito
A dihydropyridine calcium (Ca) antagonist, azelnidipine (CAS 123524-52-7, Calblock), exhibits hypotensive effects for a prolonged duration, and has been reported to have a strong antiarteriosclerotic action due to its high affinity for vascular tissues and antioxidative action. It has also been reported that azelnidipine does not cause tachycardia associated with the baroreceptor reflex due to vasodilatation. In this study, the antiarteriosclerotic and cardiac hypertrophy-inhibitory effects, and the autonomic nervous activity in essential hypertension of azelnidipine were investigated...
2007: Arzneimittel-Forschung
Andrea M Haqq, Michael Muehlbauer, Laura P Svetkey, Christopher B Newgard, Jonathan Q Purnell, Steven C Grambow, Michael S Freemark
OBJECTIVE: Prader-Willi syndrome (PWS) is a genetic syndrome characterized by relative hypoinsulinaemia and normal or increased insulin sensitivity despite profound obesity. We hypothesized that this increased insulin sensitivity is mediated by increased levels of total and high molecular weight adiponectin and associated with changes in levels of satiety hormones. DESIGN, PATIENTS AND MEASUREMENTS: We measured total adiponectin and its isoforms [high molecular weight (HMW), middle molecular weight (MMW) and low molecular weight (LMW) adiponectin] and satiety hormones in 14 children with PWS [median age 11...
December 2007: Clinical Endocrinology
Yves M Rolland, Horace M Perry, Ping Patrick, William A Banks, John E Morley
To investigate the relationships between blood levels of leptin or adiponectin and lifestyle habits, hormones, and inflammatory markers, we measured parameters of alcohol intake, smoking, physical activity, and blood levels of leptin, adiponectin, testosterone, estrone, estradiol, cortisol, dihydroepiandrostenedione, luteinizing hormone, thyroxin, C-reactive protein (CRP), and interleukin 6 and interleukin 2 receptor in 76 healthy middle-aged postmenopausal women. Anthropometric measures and body composition (evaluated by dual-energy x-ray absorptiometry) and lipid profiles were also assessed...
December 2006: Metabolism: Clinical and Experimental
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"