Yizhan Ma, Runze Zhang, Xiaoyan Mao, Xiaoming Li, Ting Li, Fang Liang, Jing He, Lili Wen, Weizuo Wang, Xiao Li, Yanhui Zhang, Honghao Yu, Binhan Lu, Tianhao Yu, Qiang Ao
Objective . Artificial nerve scaffolds composed of polymers have attracted great attention as an alternative for autologous nerve grafts recently. Due to their poor bioactivity, satisfactory nerve repair could not be achieved. To solve this problem, we introduced extracellular matrix (ECM) to optimize the materials. Approach. In this study, the ECM extracted from porcine nerves was mixed with Poly(L-Lactide-co- ϵ -caprolactone) (PLCL), and the innovative PLCL/ECM nerve repair conduits were prepared by electrostatic spinning technology...
April 4, 2024: Journal of Neural Engineering