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https://www.readbyqxmd.com/read/28732247/repairing-sciatic-nerve-injury-with-an-epo-loaded-nerve-conduit-and-sandwiched-in-strategy-of-transplanting-mesenchymal-stem-cells
#1
Wei Zhang, Lihai Zhang, Jianheng Liu, Licheng Zhang, Jian Zhang, Peifu Tang
Transplantation of a biosynthetic nerve conduit carrying neuro-protective cytokines is promising for treating peripheral nerve injury. Here we developed a novel strategy for repairing sciatic nerve injury by EPO-loaded Chitosan nerve conduit (EPO/Chi) and sandwiched-in transplantation of mesenchymal stem cells (MSCs). Then, the beneficial effect of EPO/Chi + MSCs on nerve regeneration was also further investigated by in vitro cellular experiments. In vivo experiment showed that combination of EPO-loaded Chitosan nerve conduit with MSCs could significantly accelerate nerve healing and improve morphological repair...
July 11, 2017: Biomaterials
https://www.readbyqxmd.com/read/28718615/development-of-nanofiber-sponges-containing-nerve-guidance-conduit-for-peripheral-nerve-regeneration-in-vivo
#2
Binbin Sun, Zi-Fei Zhou, Tong Wu, Weiming Chen, Dawei Li, Hao Zheng, Hany El-Hamshary, Salem S Al-Deyab, Xiumei Mo, Yinxian Yu
In the study of hollow nerve guidance conduit (NGC), the dispersion of regenerated axons always confused the researchers. To address this problem, filler-containing NGC was prepared, which showed better effect in the application of nerve tissue engineering. In this study, nanofiber sponges with abundant macro-pores, high porosity, and superior compressive strength were fabricated by electrospinning and freeze-drying. Poly (l-lactic acid-co-ε-caprolactone)/silk fibroin (PLCL/SF) nanofiber sponges were used as filler to prepare three-dimensional nanofiber sponges-containing (NS-containing) NGC...
July 18, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28718327/fibrin-glue-increases-the-tensile-strength-of-conduit-assisted-primary-digital-nerve-repair
#3
Jessica R Childe, Steven Regal, Patrick Schimoler, Alexander Kharlamov, Mark C Miller, Peter Tang
BACKGROUND: An ideal peripheral nerve repair construct does not currently exist. Our primary goal was to determine whether fibrin glue adds to the tensile strength of conduit-assisted primary digital nerve repairs. Our secondary goal was to evaluate the impact of varying suture number and location on the tensile strength. METHODS: Ninety cadaveric digital nerves were harvested and divided equally into the following repair groups: A (4/4), B (2/2), C (0/2), D (0/1), and E (0/0) with the first number referring to the number of sutures at the coaptation and the second number referring to the number of sutures at each proximal and distal end of the nerve-conduit junction...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28675568/sciatic-nerve-regeneration-by-transplantation-of-schwann-cells-via-erythropoietin-controlled-releasing-polylactic-acid-multiwalled-carbon-nanotubes-gelatin-nanofibrils-neural-guidance-conduit
#4
Majid Salehi, Mahdi Naseri-Nosar, Somayeh Ebrahimi-Barough, Mohammdreza Nourani, Arash Khojasteh, Amir-Ali Hamidieh, Amir Amani, Saeed Farzamfar, Jafar Ai
The current study aimed to enhance the efficacy of peripheral nerve regeneration using an electrically conductive biodegradable porous neural guidance conduit for transplantation of allogeneic Schwann cells (SCs). The conduit was produced from polylactic acid (PLA), multiwalled carbon nanotubes (MWCNTs), and gelatin nanofibrils (GNFs) coated with the recombinant human erythropoietin-loaded chitosan nanoparticles (rhEpo-CNPs). The PLA/MWCNTs/GNFs/rhEpo-CNPs conduit had the porosity of 85.78 ± 0.70%, the contact angle of 77...
July 4, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28673630/peripheral-nerve-defects-overviews-of-practice-in-europe
#5
REVIEW
Bruno Battiston, Paolo Titolo, Davide Ciclamini, Bernardino Panero
Many surgical techniques are available for the repair of peripheral nerve defects. Autologous nerve grafts are the gold standard for most clinical conditions. In selected cases, alternative types of reconstructions are performed to fill the nerve gap. Non-nervous autologous tissue-based conduits or synthetic ones are alternatives to nerve autografts. Allografts represent another new field of interest. Decision making in the treatment of nerve defects is based on timing of referral, level of the injury, type of lesion, and size of any gap...
August 2017: Hand Clinics
https://www.readbyqxmd.com/read/28657487/delayed-spinal-cord-brachial-plexus-reconnection-after-c7-ventral-root-avulsion-the-effect-of-reinnervating-motoneurons-rescued-by-riluzole-treatment
#6
Balázs Gloviczki, Dénes G Török, Gábor Márton, László Gál, Tamás Bodzay, Sándor Pintér, Antal Nógrádi
Ventral root avulsion induces dramatic loss of the affected spinal cord motoneurons. The neuroprotective effect of riluzole has been previously proven on the injured motoneurons: the vast majority of them can be rescued even when they have no possibility to regenerate their axons. In this study the number of injured motoneurons rescued by riluzole treatment and their capacity to reinnervate the denervated forelimb muscles was investigated. Surgical reconnection with a peripheral nerve graft between the affected spinal cord segment and the C7 spinal nerve was established immediately or with 1- and 3-week delay after avulsion...
August 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28645309/herpes-simplex-virus-1-infects-the-olfactory-bulb-shortly-following-ocular-infection-and-exhibits-a-long-term-inflammatory-profile-in-the-form-of-effector-and-hsv-1-specific-t-cells
#7
Chandra M Menendez, Daniel J J Carr
BACKGROUND: Herpes simplex virus 1 (HSV-1) infection can result in a life-threatening condition known as herpes simplex encephalitis (HSE). Trafficking patterns by which the virus reaches the central nervous system (CNS) following ocular infection are unresolved. We evaluated early viral dissemination pathways following ocular infection that involve trafficking to the olfactory bulb (OB). Additionally, we have characterized the capacity of HSV-1 to establish latency within OB tissue and profiled the local T lymphocyte response over the course of the acute infection into latency...
June 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28632137/electrospun-silk-polyaniline-conduits-for-functional-nerve-regeneration-in-rat-sciatic-nerve-injury-model
#8
Suradip Das, Manav Sharma, Dhiren Saharia, Kushal Sarma, Elizabeth Muir, Utpal Bora
The present study describes the fabrication of polyaniline-silk fibroin nanocomposite based nerve conduits and its subsequent implantation in a rat sciatic nerve injury model for peripheral nerve regeneration. This is the first in vivo study of polyaniline based nerve conduit describing the safety and efficacy of the conduits in treating peripheral nerve injuries. The nanocomposite was synthesised by electrospinning a mixture of silk fibroin protein and polyaniline wherein the silk nanofibers were observed to be uniformly coated with polyaniline nanoparticles...
June 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28604388/targeting-neuronal-gap-junctions-in-mouse-retina-offers-neuroprotection-in-glaucoma
#9
Abram Akopian, Sandeep Kumar, Hariharasubramanian Ramakrishnan, Kaushambi Roy, Suresh Viswanathan, Stewart A Bloomfield
The progressive death of retinal ganglion cells and resulting visual deficits are hallmarks of glaucoma, but the underlying mechanisms remain unclear. In many neurodegenerative diseases, cell death induced by primary insult is followed by a wave of secondary loss. Gap junctions (GJs), intercellular channels composed of subunit connexins, can play a major role in secondary cell death by forming conduits through which toxic molecules from dying cells pass to and injure coupled neighbors. Here we have shown that pharmacological blockade of GJs or genetic ablation of connexin 36 (Cx36) subunits, which are highly expressed by retinal neurons, markedly reduced loss of neurons and optic nerve axons in a mouse model of glaucoma...
June 30, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28601937/nerve-perivascular-fat-communication-as-a-potential-influence-on-the-performance-of-blood-vessels-used-as-coronary-artery-bypass-grafts
#10
Andrzej Loesch, Michael R Dashwood
Perivascular fat, the cushion of adipose tissue surrounding blood vessels, possesses dilator, anti-contractile and constrictor actions. The majority of these effects have been demonstrated in vitro and may depend on the vessel and/or the experimental method or species used. In general, the relaxant effect of perivascular adipose tissue is local and may be either endothelium-dependent or endothelium-independent. However, nerve stimulation studies show that, in general, perivascular adipose tissue (PVAT) has an anti-contractile vascular effect likely to involve an action of the autonomic vascular nerves...
June 10, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28575952/biocompatibility-and-neurotoxicity-of-magnesium-alloys-potentially-used-for-neural-repairs
#11
Jianjun Fei, Xiaoxiao Wen, Xiao Lin, Saijilafu, Weihua Wang, Olga Ren, Xinjian Chen, Lili Tan, Ke Yang, Huilin Yang, Lei Yang
Nerve injury, especially the large-size nerve damage, is a serious problem affecting millions of people. Entubulation of two ends of the injured nerve by using an implantable device, e.g., nerve guidance conduit (NGC), to guide the regeneration of nerve tissue is a promising approach for treating the large-size nerve defect. Magnesium (Mg) and its alloys are biodegradable, conductive, and own good mechanical properties. Mg(2+) ion, one of the main degradation products of Mg and its alloys, was reported to promote the proliferation of neural stem cells and their neurite production...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28561191/platelet-rich-fibrin-conduits-as-an-alternative-to-nerve-autografts-for-peripheral-nerve-repair
#12
Felipe Roth, Marcela Fernandes, Sandra G Valente, João B G Santos, Rebeca Barros Furukawa, Carlos Henrique Fernandes, Vilnei M Leite, Flávio Faloppa
No abstract text is available yet for this article.
May 22, 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/28560006/fat-tissue-a-potential-schwann-cell-reservoir-isolation-and-identification-of-adipose-derived-schwann-cells
#13
Lulu Chen, Yuqing Jin, Xiaonan Yang, Zhangyin Liu, Yang Wang, Gangyang Wang, Zuoliang Qi, Zunli Shen
Schwann cells can be used to promote peripheral nerve repair. However, it is challenging to obtain abundant autologous Schwann cells without sacrificing nerve integrity. In this study, we isolated Schwann cells from murine inguinal adipose tissue and identified the cell phenotype and function in vivo and in vitro. Through H&E and immunofluorescence staining, we detected tiny nerve fibers and Schwann cells in adipose tissue. We evaluated the phenotype of spindle-shaped cells (Schwann cell-like cells, SCLCs) isolated from adipose tissue using immunofluorescence staining and real-time RT-PCR...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28557906/ultrasound-imaging-of-median-nerve-conduit-in-a-patient-with-persistent-median-nerve-symptoms
#14
Santoshi Billakota, David S Ruch, Lisa D Hobson-Webb
Peripheral nerve injury can be reconstructed using composite polymer nerve autografts, but the sonographic appearance of nerve wraps and conduits have not been well documented. This case report describes the sonographic findings in a 42-year-old woman with bilateral carpal tunnel syndrome status post nerve repair with a conduit. The cross-sectional area of the left median nerve was 24 mm at the carpal tunnel inlet and 5 mm at the forearm. The wrist to forearm ratio was 4.8. There was a hypoechoic space surrounding the nerve that was 1...
May 25, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28556533/in-vitro-evaluation-of-gel-encapsulated-adipose-derived-stem-cells-biochemical-cues-for-in-vivo-peripheral-nerve-repair
#15
A C de Luca, C M Fonta, W Raffoul, P G di Summa, S P Lacour
Adipose-derived stem cells (ASC) are becoming one of the most exploited cells in peripheral nerve repair. They are fast-growing and able to protect neurons from apoptosis; they can reduce post-injury latency, and the risk of muscle atrophy. This study evaluates laminin-loaded fibrin gel as an ASC-carrying scaffold for nerve repair. In vitro, ASC retained their proliferative activity, but showed significant increase in proliferation rate when encapsulated in gels with low laminin concentrations (i.e. 1μg/mL)...
May 26, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28532897/mast-cells-improve-functional-recovery-of-transected-peripheral-nerve-a-novel-preliminary-study
#16
Behrooz Ilkhanizadeh, Leila Zarei, Negin Farhad, Mehran Bahrami-Bukani, Rahim Mohammadi
BACKGROUND: Employment of regenerative properties of cells at the service of nerve repair has been initiated during recent decades. Effects of local transplantation of bone marrow-derived mast cells on peripheral nerve regeneration were studied using a rat sciatic nerve transection model. MATERIALS AND METHODS: A 10-mm sciatic nerve defect was bridged using a conduit chitosan-based hybrid conduit filled with BMMCs in BMMC group. In positive control group (Pos), the conduit was filled with phosphate-buffered saline alone...
May 11, 2017: Injury
https://www.readbyqxmd.com/read/28531139/dual-component-gelatinous-peptide-reactive-oligomer-formulations-as-conduit-material-and-luminal-filler-for-peripheral-nerve-regeneration
#17
Caroline Kohn-Polster, Divya Bhatnagar, Derek J Woloszyn, Matthew Richtmyer, Annett Starke, Alexandra H Springwald, Sandra Franz, Michaela Schulz-Siegmund, Hilton M Kaplan, Joachim Kohn, Michael C Hacker
Toward the next generation of nerve guidance conduits (NGCs), novel biomaterials and functionalization concepts are required to address clinical demands in peripheral nerve regeneration (PNR). As a biological polymer with bioactive motifs, gelatinous peptides are promising building blocks. In combination with an anhydride-containing oligomer, a dual-component hydrogel system (cGEL) was established. First, hollow cGEL tubes were fabricated by a continuous dosing and templating process. Conduits were characterized concerning their mechanical strength, in vitro and in vivo degradation and biocompatibility...
May 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28529011/the-effect-of-in-vivo-created-vascularized-neurotube-on-peripheric-nerve-regeneration
#18
Abdul Kerim Yapici, Yalcin Bayram, Hakan Akgun, Recep Gumus, Fatih Zor
INTRODUCTION: Creating vascularized nerve conduits for treatment of nerve gaps have been researched, however, these methods need microsurgical anastomosis thereby complicating the nerve repair process. Thus, the concept of vascularized nerve conduits has not popularized up till now. The aim of this study is to evaluate the effects of vascularized and non-vascularized biological conduits on peripheral nerve regeneration. MATERIAL AND METHODS: Following ethical board approval, 15 Sprague-Dawley rats were used in the study...
May 11, 2017: Injury
https://www.readbyqxmd.com/read/28522397/cellulose-acetate-poly-lactic-acid-coaxial-wet-electrospun-scaffold-containing-citalopram-loaded-gelatin-nanocarriers-for-neural-tissue-engineering-applications
#19
Mahdi Naseri-Nosar, Majid Salehi, Shahriar Hojjati-Emami
The current study aimed to develop a biodegradable three-dimensional drug-loaded scaffold with the core-shell structured fibrils using coaxial wet-electrospinning for neural tissue engineering application. Poly lactic acid was wet-electrospun as the core, whereas cellulose acetate was fabricated into the fibril's shell. The scaffold then was coated with the citalopram-loaded gelatin nanocarriers (CGNs) produced by nanoprecipitation method. Scanning electron microscope observation revealed that the fibrils formed a nonwoven structure with the average diameter of ∼950nm...
May 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28509699/penis-transplantation-first-us-experience
#20
Curtis L Cetrulo, Kai Li, Harry M Salinas, Matthew D Treiser, Ilse Schol, Glen W Barrisford, Francis J McGovern, Adam S Feldman, Michael T Grant, Cigdem Tanrikut, Jeffrey H Lee, Richard J Ehrlichman, Paul W Holzer, Garry M Choy, Raymond W Liu, Zhi Yang Ng, Alexandre G Lellouch, Josef M Kurtz, William G Austen, Jonathan M Winograd, Branko Bojovic, Kyle R Eberlin, Ivy A Rosales, Robert B Colvin, Dicken S C Ko
OBJECTIVE: We describe the first successful penis transplant in the United States in a patient with a history of subtotal penectomy for penile cancer. BACKGROUND: Penis transplantation represents a new paradigm in restoring anatomic appearance, urine conduit, and sexual function after genitourinary tissue loss. To date, only 2 penis transplants have been performed worldwide. METHODS: After institutional review board approval, extensive medical, surgical, and radiological evaluations of the patient were performed...
May 15, 2017: Annals of Surgery
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