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https://www.readbyqxmd.com/read/28076883/in-vivo-feasibility-test-using-transparent-carbon-nanotube-coated-polydimethylsiloxane-sheet-at-brain-tissue-and-sciatic-nerve
#1
Caifeng Wang, Sangjin Oh, Hyun Ah Lee, Jieun Kang, Ki-Jae Jeong, Seon Woo Kang, Dae Youn Hwang, Jaebeom Lee
Carbon nanotubes (CNTs), with their unique and outstanding properties, such as strong mechanical strength and high electrical conductivity, have become very popular for the repair of tissues, particularly for those requiring electrical stimuli. Polydimethylsiloxane (PDMS)-based elastomers have been used in a wide range of biomedical applications because of their optical transparency, physiological inertness, blood compatibility, non-toxicity, and gas permeability. In present study, most of artificial nerve guidance conduits (ANGCs) are not transparent...
January 11, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28073285/muscle-nerve-muscle-grafting-for-facial-reanimation-in-rats
#2
Steven J Charous, Jeffery M Hotaling, Bridget D Burgess, Joshua M Sappington, James Park, Grant Turek, Eileen M Foecking
OBJECTIVE: Facial paralysis is a devastating condition leaving patients with a myriad of aesthetic and functional consequences. Muscle-nerve-muscle (MNM) neurotization is a reinnervation technique that involves implanting an autogenous nerve graft as a conduit between an innervated "donor" muscle and a denervated "recipient" muscle. We investigated the use of MNM reinnervation, alone or in combination with electrical stimulation (ES) and testosterone propionate (TP) in comparison to nerve reanastomosis (RE), on functional recovery following rat facial nerve injury...
January 1, 2017: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/28052540/engineered-neural-tissue-with-schwann-cell-differentiated-human-dental-pulp-stem-cells-potential-for-peripheral-nerve-repair
#3
Kathleen Sanen, Wendy Martens, Melanie Georgiou, Marcel Ameloot, Ivo Lambrichts, James Phillips
Despite the spontaneous regenerative capacity of the peripheral nervous system, large gap peripheral nerve injuries (PNIs) require bridging strategies. The limitations and suboptimal results obtained with autografts or hollow nerve conduits in the clinic urge the need for alternative treatments. Recently, we have described promising neuroregenerative capacities of Schwann cells derived from differentiated human dental pulp stem cells (d-hDPSCs) in vitro. Here, we extended the in vitro assays to show the pro-angiogenic effects of d-hDPSCs, such as enhanced endothelial cell proliferation, migration and differentiation...
January 4, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28012041/brain-to-stomach-transfer-of-%C3%AE-synuclein-via-vagal-preganglionic-projections
#4
Ayse Ulusoy, Robert J Phillips, Michael Helwig, Michael Klinkenberg, Terry L Powley, Donato A Di Monte
Detection of α-synuclein lesions in peripheral tissues is a feature of human synucleinopathies of likely pathogenetic relevance and bearing important clinical implications. Experiments were carried out to elucidate the relationship between α-synuclein accumulation in the brain and in peripheral organs, and to identify potential pathways involved in long-distance protein transfer. Results of this in vivo study revealed a route-specific transmission of α-synuclein from the rat brain to the stomach. Following targeted midbrain overexpression of human α-synuclein, the exogenous protein was capable of reaching the gastric wall where it was accumulated into preganglionic vagal terminals...
December 23, 2016: Acta Neuropathologica
https://www.readbyqxmd.com/read/28008303/regenerated-sciatic-nerve-axons-stimulated-through-a-chronically-implanted-macro-sieve-electrode
#5
Matthew R MacEwan, Erik R Zellmer, Jesse J Wheeler, Harold Burton, Daniel W Moran
Sieve electrodes provide a chronic interface for stimulating peripheral nerve axons. Yet, successful utilization requires robust axonal regeneration through the implanted electrode. The present study determined the effect of large transit zones in enhancing axonal regeneration and revealed an intimate neural interface with an implanted sieve electrode. Fabrication of the polyimide sieve electrodes employed sacrificial photolithography. The manufactured macro-sieve electrode (MSE) contained nine large transit zones with areas of ~0...
2016: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/27989353/nerve-transfer-with-entubulated-nerve-allograft-transfers-to-treat-recalcitrant-lower-extremity-neuromas
#6
Christopher Bibbo, Edgardo Rodrigues-Colazzo
Neuroma formation in the lower extremity can be debilitating to patients, especially when the neuromas are recurrent. The results of an advanced nerve reconstruction technique consisting of nerve transfer combined with nerve allograft and entubulation was evaluated in 4 patients with severe, debilitating, lower extremity neuromas. At a mean follow-up period of 26 months, the mean visual analog scale had improved from 9.5 preoperatively to 1.25 postoperatively (p < .05). These data suggest that techniques using a nerve allograft with a nerve conduit could be of great assistance in successfully managing debilitating neuromas of the lower extremity...
January 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/27983992/single-injection-of-a-novel-nerve-growth-factor-coacervate-improves-structural-and-functional-regeneration-after-sciatic-nerve-injury-in-adult-rats
#7
Rui Li, Jiang Wu, Zhenkun Lin, Matthew R Nangle, Yi Li, Pingtao Cai, Dan Liu, Libin Ye, Zecong Xiao, Chaochao He, Jingjing Ye, Hongyu Zhang, Yingzheng Zhao, Jian Wang, Xiaokun Li, Yan He, Qingsong Ye, Jian Xiao
The prototypical neurotrophin, nerve growth factor (NGF), plays an important role in the development and maintenance of many neurons in both the central and peripheral nervous systems, and can promote functional recovery after peripheral nerve injury in adulthood. However, repair of peripheral nerve defects is hampered by the short half-life of NGF in vivo, and treatment with either NGF alone or NGF contained in synthetic nerve conduits is inferior to the use of nerve autografts, the current gold standard. We tested the reparative ability of a single local injection of a polyvalent coacervate containing polycation-poly(ethylene argininylaspartate diglyceride; PEAD), heparin, and NGF, in adult rats following sciatic nerve crush injury, using molecular, histological and behavioral approaches...
February 2017: Experimental Neurology
https://www.readbyqxmd.com/read/27973708/peot-pbt-guides-enhance-nerve-regeneration-in-long-gap-defects
#8
Daniel Santos, Paul Wieringa, Lorenzo Moroni, Xavier Navarro, Jaume Del Valle
Development of new nerve guides is required for replacing autologous nerve grafts for the repair of long gap defects after nerve injury. A nerve guide comprised only of electrospun fibers able to bridge a critical (15 mm) nerve gap in a rat animal model is reported for the first time. The nerve conduits are made of poly(ethylene oxide terephthalate) and poly(butylene terephthalate) (PEOT/PBT), a biocompatible copolymer composed of alternating amorphous, hydrophilic poly(ethylene oxide terephthalate), and crystalline, hydrophobic poly(butylene terephthalate) segments...
December 14, 2016: Advanced Healthcare Materials
https://www.readbyqxmd.com/read/27940160/neural-stem-progenitor-cells-on-collagen-with-anchored-basic-fibroblast-growth-factor-as-potential-natural-nerve-conduits-for-facial-nerve-regeneration
#9
Fukai Ma, Tongming Zhu, Feng Xu, Zhifu Wang, Yongtao Zheng, Qisheng Tang, Luping Chen, Yiwen Shen, Jianhong Zhu
: Introducing neural stem/progenitor cells (NS/PCs) for repairing facial nerve injuries could be an alternative strategy for nerve gap reconstruction. However, the lack of success associated with current methods of applying NS/PCs to neurological disease is due to poor engraftment following transplantation into the host tissue. In this work, we developed rat-tail collagen-based nerve conduits to repair lengthy facial nerve defects, promoting NS/PC proliferation in the natural nerve conduits with anchored bFGF to improve the therapeutic effects of cell transplantation...
December 7, 2016: Acta Biomaterialia
https://www.readbyqxmd.com/read/27916868/characterization-and-schwann-cell-seeding-of-up-to-15-0-cm-long-spider-silk-nerve-conduits-for-reconstruction-of-peripheral-nerve-defects
#10
Tim Kornfeld, Peter M Vogt, Vesna Bucan, Claas-Tido Peck, Kerstin Reimers, Christine Radtke
Nerve reconstruction of extended nerve defect injuries still remains challenging with respect to therapeutic options. The gold standard in nerve surgery is the autologous nerve graft. Due to the limitation of adequate donor nerves, surgical alternatives are needed. Nerve grafts made out of either natural or artificial materials represent this alternative. Several biomaterials are being explored and preclinical and clinical applications are ongoing. Unfortunately, nerve conduits with successful enhancement of axonal regeneration for nerve defects measuring over 4...
November 30, 2016: Journal of Functional Biomaterials
https://www.readbyqxmd.com/read/27893553/healing-effects-of-platelet-rich-plasma-on-peripheral-nerve-injuries
#11
Farshid Bastami, Peyman Vares, Arash Khojasteh
Regeneration of peripheral nerve injuries (PNIs) has been a major challenging issue in regenerative medicine and tissue engineering. Inferior alveolar nerve and lingual nerve injuries are the major difficulties and complications of oral surgeries following dental implant placement, etc. The aim of this study was to systematically review the effects of platelet-rich plasma (PRP) on the regeneration of PNIs. Medline NCBI databases were searched for related articles up to and including May 2016. Being published in English papers, use of PRP in peripheral nerve regeneration, in vivo studies, and having histological evaluations was the inclusion criteria...
November 23, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27892726/design-and-characterization-of-neurodurable-gellan-xanthan-ph-responsive-hydrogels-for-controlled-drug-delivery
#12
Poornima Ramburrun, Pradeep Kumar, Yahya E Choonara, Lisa C du Toit, Viness Pillay
OBJECTIVES: The purpose of this study was to develop novel, porous neurodurable interpenetrating networks of gellan-xanthan hydrogel conduits intercalated with pristine polymethyl methacrylate (PMMA) particles for the sustained and concurrent release of two model compounds: bovine serum albumin (BSA) and diclofenac sodium. METHODS: Hydrogel conduits were synthesized using a thermal-ionic crosslinking mechanism with direct incorporation of PMMA. The 15 formulations, generated using a Box-Behnken experimental design, were analyzed for drug release, swelling, erosion and textural properties...
December 21, 2016: Expert Opinion on Drug Delivery
https://www.readbyqxmd.com/read/27889918/inner-ear-labyrinth-anatomy-of-monotremes-and-implications-for-mammalian-inner-ear-evolution
#13
Julia A Schultz, Ulrich Zeller, Zhe-Xi Luo
The monophyletic clade Monotremata branches early from the rest of the mammalian crown group in the Jurassic and members of this clade retain many ancestral mammalian traits. Thus, accurate and detailed anatomical descriptions of this group can offer unique insight into the early evolutionary history of Mammalia. In this study, we examine the inner ear anatomy of two extant monotremes, Ornithorhynchus anatinus and Tachyglossus aculeatus, with the primary goals of elucidating the ancestral mammalian ear morphology and resolving inconsistencies found within previous descriptive literature...
November 27, 2016: Journal of Morphology
https://www.readbyqxmd.com/read/27877111/polymerizing-pyrrole-coated-poly-l-lactic-acid-co-%C3%AE%C2%B5-caprolactone-plcl-conductive-nanofibrous-conduit-combined-with-electric-stimulation-for-long-range-peripheral-nerve-regeneration
#14
Jialin Song, Binbin Sun, Shen Liu, Wei Chen, Yuanzheng Zhang, Chunyang Wang, Xiumei Mo, Junyi Che, Yuanming Ouyang, Weien Yuan, Cunyi Fan
Electrospinning and electric stimulation (ES) are both promising methods to support neuron adhesion and guide extension of neurons for nerve regeneration. Concurrently, all studies focus on either electrospinning for conduits material or ES in vitro study to accelerate nerve regeneration; few work on the combined use of these two strategies or ES in vivo study. Therefore, this study aimed to investigate the abilities of direct current ES through electrospinning conductive polymer composites composed of polypyrrole and Poly (l-lactic acid-co-ε-caprolactone) (PPY/PLCL) in peripheral nerve regeneration...
2016: Frontiers in Molecular Neuroscience
https://www.readbyqxmd.com/read/27876000/comparison-of-repair-of-peripheral-nerve-transection-in-predegenerated-muscle-with-and-without-a-vein-graft
#15
COMPARATIVE STUDY
Jamshid Mohammadi, Hamdollah Delaviz, Bahram Mohammadi, Hamoun Delaviz, Parastou Rad
BACKGROUND: Despite substantial research into the topic and valiant surgical efforts, reconstruction of peripheral nerve injury remains a challenging surgery. This study was conducted to evaluate the effectiveness of axonal regeneration of a transected sciatic nerve through a vein conduit containing degenerated skeletal muscle compared with axonal regeneration in a transected sciatic nerve through degenerated skeletal muscle alone. METHODS: In two of the three experimental rat groups, 10 mm of the left sciatic nerve was transected and removed...
November 22, 2016: BMC Neurology
https://www.readbyqxmd.com/read/27874834/recovery-of-erectile-function-comparing-autologous-nerve-grafts-unseeded-conduits-schwann-cell-seeded-guidance-tubes-and-gdnf-overexpressing-schwann-cell-grafts
#16
Florian May, Alexander Buchner, Kaspar Matiasek, Boris Schlenker, Christian Stief, Norbert Weidner
Dissection of the cavernous nerves during radical prostatectomy for prostate cancer eliminates spontaneous erections. Using the rat as an experimental model, we compared the regenerative capacity of autologous nerve grafts and Schwann-cell-seeded nerve guides. After bilateral excision of cavernous nerve segments, cavernous nerves were reconstructed using unseeded silicon tubes, nerve autografts and silicon tubes seeded with either Glial-cell-line-derived (GDNF)-overexpressing or green fluorescent protein (GFP)-expressing Schwann cells (SCs) (16 study nerves per group)...
December 1, 2016: Disease Models & Mechanisms
https://www.readbyqxmd.com/read/27865767/neural-stem-cells-promote-nerve-regeneration-through-il12-induced-schwann-cell-differentiation
#17
Don-Ching Lee, Jong-Hang Chen, Tai-Yu Hsu, Li-Hsun Chang, Hsu Chang, Ya-Hui Chi, Ing-Ming Chiu
Regeneration of injured peripheral nerves is a slow, complicated process that could be improved by implantation of neural stem cells (NSCs) or nerve conduit. Implantation of NSCs along with conduits promotes the regeneration of damaged nerve, likely because (i) conduit supports and guides axonal growth from one nerve stump to the other, while preventing fibrous tissue ingrowth and retaining neurotrophic factors; and (ii) implanted NSCs differentiate into Schwann cells and maintain a growth factor enriched microenvironment, which promotes nerve regeneration...
November 16, 2016: Molecular and Cellular Neurosciences
https://www.readbyqxmd.com/read/27865067/laminin-modified-and-aligned-phbv-peo-nanofibrous-nerve-conduits-promote-peripheral-nerve-regeneration
#18
Xiao-Feng Zhang, Hai-Xia Liu, Lazarus Santiago Ortiz, Zhong-Dang Xiao, Ning-Ping Huang
Poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) has received much attention for its biodegradability and biocompatibility, characteristics which are required in tissue engineering. In this study, polyethylene oxide (PEO)-incorporated PHBV nanofibers with random or aligned orientation were obtained by electrospinning. For further use in vivo, the nanofiber films were made into nerve conduits after treated with NH3 plasma, which could improve the hydrophilicity of inner surfaces of nerve conduits and then facilitate laminin adsorption via electrostatic interaction for promoting cell adhesion and proliferation...
November 12, 2016: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/27864151/gelatin-nanoceria-nanocomposite-fibers-as-antioxidant-scaffolds-for-neuronal-regeneration
#19
Attilio Marino, Chiara Tonda-Turo, Daniele De Pasquale, Francesca Ruini, Giada Genchi, Simone Nitti, Valentina Cappello, Mauro Gemmi, Virgilio Mattoli, Gianluca Ciardelli, Gianni Ciofani
BACKGROUND: The design of efficient nerve conduits able to sustain the axonal outgrowth and its guidance towards appropriate targets is of paramount importance in nerve tissue engineering. METHODS: In this work, we propose the preparation of highly aligned nanocomposite fibers of gelatin/cerium oxide nanoparticles (nanoceria), prepared by electrospinning. Nanoceria are powerful self-regenerative antioxidant nanomaterials, that behave as strong reactive oxygen species scavengers, and among various beneficial effects, they have been proven to inhibit the cell senescence and to promote the neurite sprouting...
February 2017: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27861947/recurrent-laryngeal-nerve-regeneration-using-an-oriented-collagen-scaffold-containing-schwann-cells
#20
Shun-Ichi Chitose, Kiminori Sato, Mioko Fukahori, Shintaro Sueyoshi, Takashi Kurita, Hirohito Umeno
OBJECTIVES/HYPOTHESIS: Regeneration of the recurrent laryngeal nerve (RLN), which innervates the intrinsic laryngeal muscles such that they can perform complex functions, is particularly difficult to achieve. Synkinesis after RLN neogenesis leads to uncoordinated movement of laryngeal muscles. Recently, some basic research studies have used cultured Schwann cells (SCs) to repair peripheral nerve injuries. This study aimed to regenerate the RLN using an oriented collagen scaffold containing cultured SCs...
November 15, 2016: Laryngoscope
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