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https://www.readbyqxmd.com/read/28804998/peripheral-nerve-growth-within-a-hydrogel-microchannel-scaffold-supported-by-a-kink-resistant-conduit
#1
Dena Shahriari, Masataka Shibayama, Daniel Lynam, Kayla Wolf, Go Kubota, Jacob Koffler, Mark Tuszynski, Wendy Campana, Jeff Sakamoto
Nerve repair in several mm-long nerve gaps often requires an interventional technology. Microchannel scaffolds have proven effective for bridging nerve gaps and guiding axons in the peripheral nervous system (PNS). Nonetheless, fabricating microchannel scaffolds at this length scale remains a challenge and/or is time consuming and cumbersome. In this work, a simple computer-aided microdrilling technique was used to fabricate 10 mm-long agarose scaffolds consisting of 300 µm-microchannels and 85 µm-thick walls in less than an hour...
August 14, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782192/the-effect-of-four-types-of-artificial-nerve-graft-structures-on-the-repair-of-10-mm-rat-sciatic-nerve-gap
#2
Chan Zhou, Bin Liu, Yong Huang, Xiu Zeng, Huajian You, Jin Li, Yaoguang Zhang
Investigating the effect of four types of artificial nerve graft (ANG) structures on rat sciatic nerve defect repair will aid future ANG designs. In this study, fibroin fibres and polylactic acid were used to prepare four ANGs with differing structures: nerve conduit with micron-sized pores (Conduit with pore group), nerve conduit without micron-sized pores (Conduit group), nerve scaffold comprising Conduit with pore group material plus silk fibres (Scaffold with pore group), and nerve scaffold comprising Conduit group material plus silk fibres (Scaffold group)...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28782170/short-and-long-gap-peripheral-nerve-repair-with-magnesium-metal-filaments
#3
Tracy M Hopkins, Kevin J Little, John J Vennemeyer, Jefferson L Triozzi, Michael T Turgeon, Alexander M Heilman, D Minteer, K Marra, David B Hom, Sarah K Pixley
A current clinical challenge is to replace autografts for repair of injury gaps in peripheral nerves, which can occur due to trauma or surgical interruption. Biodegradable metallic magnesium filaments, placed inside hollow nerve conduits, could support nerve repair by providing contact guidance support for axonal regeneration. This was tested by repairing sciatic nerves of adult rats with single magnesium filaments placed inside poly(caprolactone) nerve conduits. Controls were empty conduits, conduits containing titanium filaments and/or isografts from donor rats...
August 7, 2017: Journal of Biomedical Materials Research. Part A
https://www.readbyqxmd.com/read/28754648/microtopographical-cues-promote-peripheral-nerve-regeneration-via-transient-mtorc2-activation
#4
Suzanne E Thomson, Chloe Charalambous, Carol-Anne Smith, Penelope M Tsimbouri, Theophile Déjardin, Paul J Kingham, Andrew M Hart, Mathis O Riehle
Despite microsurgical repair, recovery of function following peripheral nerve injury is slow and often incomplete. Outcomes could be improved by an increased understanding of the molecular biology of regeneration and by translation of experimental bioengineering strategies. Topographical cues have been shown to be powerful regulators of the rate and directionality of neurite regeneration, and in this study we investigated the downstream molecular effects of linear micropatterned structures in an organotypic explant model...
July 25, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28737460/-applied-methods-instead-of-autologous-nerve-transplantation-in-the-reconstruction-of-nerve-injuries-on-the-hand
#5
Vilmos Bíró
For a long time in the clinical practice the autologous nerve transplants are used in reconstruction of the segmental defects of injured hand nerves. The published outcomes, especially in case of the motor and mixed (sensory and motor) nerves, however, were not satisfactory. Hence, it remained a problem and in the focus of research. The author aimed to study this topic and drawing conclusions in his literary review publication. According to the recent results, the replacement of the autologous nerve transplants with other materials (e...
July 2017: Orvosi Hetilap
https://www.readbyqxmd.com/read/28732247/repairing-sciatic-nerve-injury-with-an-epo-loaded-nerve-conduit-and-sandwiched-in-strategy-of-transplanting-mesenchymal-stem-cells
#6
Wei Zhang, Lihai Zhang, Jianheng Liu, Licheng Zhang, Jian Zhang, Peifu Tang
Transplantation of a biosynthetic nerve conduit carrying neuro-protective cytokines is promising for treating peripheral nerve injury. Here we developed a novel strategy for repairing sciatic nerve injury by EPO-loaded Chitosan nerve conduit (EPO/Chi) and sandwiched-in transplantation of mesenchymal stem cells (MSCs). Then, the beneficial effect of EPO/Chi + MSCs on nerve regeneration was also further investigated by in vitro cellular experiments. In vivo experiment showed that combination of EPO-loaded Chitosan nerve conduit with MSCs could significantly accelerate nerve healing and improve morphological repair...
October 2017: Biomaterials
https://www.readbyqxmd.com/read/28718615/development-of-nanofiber-sponges-containing-nerve-guidance-conduit-for-peripheral-nerve-regeneration-in-vivo
#7
Binbin Sun, Zifei Zhou, Tong Wu, Weiming Chen, Dawei Li, Hao Zheng, Hany El-Hamshary, Salem S Al-Deyab, Xiumei Mo, Yinxian Yu
In the study of hollow nerve guidance conduit (NGC), the dispersion of regenerated axons always confused researchers. To address this problem, filler-containing NGC was prepared, which showed better effect in the application of nerve tissue engineering. In this study, nanofiber sponges with abundant macropores, high porosity, and superior compressive strength were fabricated by electrospinning and freeze-drying. Poly(l-lactic acid-co-ε-caprolactone)/silk fibroin (PLCL/SF) nanofiber sponges were used as filler to prepare three-dimensional nanofiber sponges-containing (NS-containing) NGC...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28718327/fibrin-glue-increases-the-tensile-strength-of-conduit-assisted-primary-digital-nerve-repair
#8
Jessica R Childe, Steven Regal, Patrick Schimoler, Alexander Kharlamov, Mark C Miller, Peter Tang
BACKGROUND: An ideal peripheral nerve repair construct does not currently exist. Our primary goal was to determine whether fibrin glue adds to the tensile strength of conduit-assisted primary digital nerve repairs. Our secondary goal was to evaluate the impact of varying suture number and location on the tensile strength. METHODS: Ninety cadaveric digital nerves were harvested and divided equally into the following repair groups: A (4/4), B (2/2), C (0/2), D (0/1), and E (0/0) with the first number referring to the number of sutures at the coaptation and the second number referring to the number of sutures at each proximal and distal end of the nerve-conduit junction...
February 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28675568/sciatic-nerve-regeneration-by-transplantation-of-schwann-cells-via-erythropoietin-controlled-releasing-polylactic-acid-multiwalled-carbon-nanotubes-gelatin-nanofibrils-neural-guidance-conduit
#9
Majid Salehi, Mahdi Naseri-Nosar, Somayeh Ebrahimi-Barough, Mohammdreza Nourani, Arash Khojasteh, Amir-Ali Hamidieh, Amir Amani, Saeed Farzamfar, Jafar Ai
The current study aimed to enhance the efficacy of peripheral nerve regeneration using an electrically conductive biodegradable porous neural guidance conduit for transplantation of allogeneic Schwann cells (SCs). The conduit was produced from polylactic acid (PLA), multiwalled carbon nanotubes (MWCNTs), and gelatin nanofibrils (GNFs) coated with the recombinant human erythropoietin-loaded chitosan nanoparticles (rhEpo-CNPs). The PLA/MWCNTs/GNFs/rhEpo-CNPs conduit had the porosity of 85.78 ± 0.70%, the contact angle of 77...
July 4, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28673630/peripheral-nerve-defects-overviews-of-practice-in-europe
#10
REVIEW
Bruno Battiston, Paolo Titolo, Davide Ciclamini, Bernardino Panero
Many surgical techniques are available for the repair of peripheral nerve defects. Autologous nerve grafts are the gold standard for most clinical conditions. In selected cases, alternative types of reconstructions are performed to fill the nerve gap. Non-nervous autologous tissue-based conduits or synthetic ones are alternatives to nerve autografts. Allografts represent another new field of interest. Decision making in the treatment of nerve defects is based on timing of referral, level of the injury, type of lesion, and size of any gap...
August 2017: Hand Clinics
https://www.readbyqxmd.com/read/28657487/delayed-spinal-cord-brachial-plexus-reconnection-after-c7-ventral-root-avulsion-the-effect-of-reinnervating-motoneurons-rescued-by-riluzole-treatment
#11
Balázs Gloviczki, Dénes G Török, Gábor Márton, László Gál, Tamás Bodzay, Sándor Pintér, Antal Nógrádi
Ventral root avulsion induces dramatic loss of the affected spinal cord motoneurons. The neuroprotective effect of riluzole has been previously proven on the injured motoneurons: the vast majority of them can be rescued even when they have no possibility to regenerate their axons. In this study the number of injured motoneurons rescued by riluzole treatment and their capacity to reinnervate the denervated forelimb muscles was investigated. Surgical reconnection with a peripheral nerve graft between the affected spinal cord segment and the C7 spinal nerve was established immediately or with 1- and 3-week delay after avulsion...
August 1, 2017: Journal of Neurotrauma
https://www.readbyqxmd.com/read/28645309/herpes-simplex-virus-1-infects-the-olfactory-bulb-shortly-following-ocular-infection-and-exhibits-a-long-term-inflammatory-profile-in-the-form-of-effector-and-hsv-1-specific-t-cells
#12
Chandra M Menendez, Daniel J J Carr
BACKGROUND: Herpes simplex virus 1 (HSV-1) infection can result in a life-threatening condition known as herpes simplex encephalitis (HSE). Trafficking patterns by which the virus reaches the central nervous system (CNS) following ocular infection are unresolved. We evaluated early viral dissemination pathways following ocular infection that involve trafficking to the olfactory bulb (OB). Additionally, we have characterized the capacity of HSV-1 to establish latency within OB tissue and profiled the local T lymphocyte response over the course of the acute infection into latency...
June 23, 2017: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/28632137/electrospun-silk-polyaniline-conduits-for-functional-nerve-regeneration-in-rat-sciatic-nerve-injury-model
#13
Suradip Das, Manav Sharma, Dhiren Saharia, Kushal Sarma, Elizabeth Muir, Utpal Bora
The present study describes the fabrication of polyaniline-silk fibroin nanocomposite based nerve conduits and its subsequent implantation in a rat sciatic nerve injury model for peripheral nerve regeneration. This is the first in vivo study of polyaniline based nerve conduit describing the safety and efficacy of the conduits in treating peripheral nerve injuries. The nanocomposite was synthesised by electrospinning a mixture of silk fibroin protein and polyaniline wherein the silk nanofibers were observed to be uniformly coated with polyaniline nanoparticles...
June 20, 2017: Biomedical Materials
https://www.readbyqxmd.com/read/28604388/targeting-neuronal-gap-junctions-in-mouse-retina-offers-neuroprotection-in-glaucoma
#14
Abram Akopian, Sandeep Kumar, Hariharasubramanian Ramakrishnan, Kaushambi Roy, Suresh Viswanathan, Stewart A Bloomfield
The progressive death of retinal ganglion cells and resulting visual deficits are hallmarks of glaucoma, but the underlying mechanisms remain unclear. In many neurodegenerative diseases, cell death induced by primary insult is followed by a wave of secondary loss. Gap junctions (GJs), intercellular channels composed of subunit connexins, can play a major role in secondary cell death by forming conduits through which toxic molecules from dying cells pass to and injure coupled neighbors. Here we have shown that pharmacological blockade of GJs or genetic ablation of connexin 36 (Cx36) subunits, which are highly expressed by retinal neurons, markedly reduced loss of neurons and optic nerve axons in a mouse model of glaucoma...
June 30, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28601937/nerve-perivascular-fat-communication-as-a-potential-influence-on-the-performance-of-blood-vessels-used-as-coronary-artery-bypass-grafts
#15
Andrzej Loesch, Michael R Dashwood
Perivascular fat, the cushion of adipose tissue surrounding blood vessels, possesses dilator, anti-contractile and constrictor actions. The majority of these effects have been demonstrated in vitro and may depend on the vessel and/or the experimental method or species used. In general, the relaxant effect of perivascular adipose tissue is local and may be either endothelium-dependent or endothelium-independent. However, nerve stimulation studies show that, in general, perivascular adipose tissue (PVAT) has an anti-contractile vascular effect likely to involve an action of the autonomic vascular nerves...
June 10, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28575952/biocompatibility-and-neurotoxicity-of-magnesium-alloys-potentially-used-for-neural-repairs
#16
Jianjun Fei, Xiaoxiao Wen, Xiao Lin, Saijilafu, Weihua Wang, Olga Ren, Xinjian Chen, Lili Tan, Ke Yang, Huilin Yang, Lei Yang
Nerve injury, especially the large-size nerve damage, is a serious problem affecting millions of people. Entubulation of two ends of the injured nerve by using an implantable device, e.g., nerve guidance conduit (NGC), to guide the regeneration of nerve tissue is a promising approach for treating the large-size nerve defect. Magnesium (Mg) and its alloys are biodegradable, conductive, and own good mechanical properties. Mg(2+) ion, one of the main degradation products of Mg and its alloys, was reported to promote the proliferation of neural stem cells and their neurite production...
September 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28561191/platelet-rich-fibrin-conduits-as-an-alternative-to-nerve-autografts-for-peripheral-nerve-repair
#17
Felipe Roth, Marcela Fernandes, Sandra G Valente, João B G Santos, Rebeca Barros Furukawa, Carlos Henrique Fernandes, Vilnei M Leite, Flávio Faloppa
No abstract text is available yet for this article.
May 22, 2017: Journal of Reconstructive Microsurgery
https://www.readbyqxmd.com/read/28560006/fat-tissue-a-potential-schwann-cell-reservoir-isolation-and-identification-of-adipose-derived-schwann-cells
#18
Lulu Chen, Yuqing Jin, Xiaonan Yang, Zhangyin Liu, Yang Wang, Gangyang Wang, Zuoliang Qi, Zunli Shen
Schwann cells can be used to promote peripheral nerve repair. However, it is challenging to obtain abundant autologous Schwann cells without sacrificing nerve integrity. In this study, we isolated Schwann cells from murine inguinal adipose tissue and identified the cell phenotype and function in vivo and in vitro. Through H&E and immunofluorescence staining, we detected tiny nerve fibers and Schwann cells in adipose tissue. We evaluated the phenotype of spindle-shaped cells (Schwann cell-like cells, SCLCs) isolated from adipose tissue using immunofluorescence staining and real-time RT-PCR...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28557906/ultrasound-imaging-of-median-nerve-conduit-in-a-patient-with-persistent-median-nerve-symptoms
#19
Santoshi Billakota, David S Ruch, Lisa D Hobson-Webb
Peripheral nerve injury can be reconstructed using composite polymer nerve autografts, but the sonographic appearance of nerve wraps and conduits have not been well documented. This case report describes the sonographic findings in a 42-year-old woman with bilateral carpal tunnel syndrome status post nerve repair with a conduit. The cross-sectional area of the left median nerve was 24 mm at the carpal tunnel inlet and 5 mm at the forearm. The wrist to forearm ratio was 4.8. There was a hypoechoic space surrounding the nerve that was 1...
May 25, 2017: Journal of Clinical Neurophysiology: Official Publication of the American Electroencephalographic Society
https://www.readbyqxmd.com/read/28556533/in-vitro-evaluation-of-gel-encapsulated-adipose-derived-stem-cells-biochemical-cues-for-in-vivo-peripheral-nerve-repair
#20
A C de Luca, C M Fonta, W Raffoul, P G di Summa, S P Lacour
Adipose-derived stem cells (ASC) are becoming one of the most exploited cells in peripheral nerve repair. They are fast-growing and able to protect neurons from apoptosis; they can reduce post-injury latency, and the risk of muscle atrophy. This study evaluates laminin-loaded fibrin gel as an ASC-carrying scaffold for nerve repair. In vitro, ASC retained their proliferative activity, but showed significant increase in proliferation rate when encapsulated in gels with low laminin concentrations (i.e. 1μg/mL)...
May 26, 2017: Journal of Tissue Engineering and Regenerative Medicine
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