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https://www.readbyqxmd.com/read/28531139/dual-component-gelatinous-peptide-reactive-oligomer-formulations-as-conduit-material-and-luminal-filler-for-peripheral-nerve-regeneration
#1
Caroline Kohn-Polster, Divya Bhatnagar, Derek J Woloszyn, Matthew Richtmyer, Annett Starke, Alexandra H Springwald, Sandra Franz, Michaela Schulz-Siegmund, Hilton M Kaplan, Joachim Kohn, Michael C Hacker
Toward the next generation of nerve guidance conduits (NGCs), novel biomaterials and functionalization concepts are required to address clinical demands in peripheral nerve regeneration (PNR). As a biological polymer with bioactive motifs, gelatinous peptides are promising building blocks. In combination with an anhydride-containing oligomer, a dual-component hydrogel system (cGEL) was established. First, hollow cGEL tubes were fabricated by a continuous dosing and templating process. Conduits were characterized concerning their mechanical strength, in vitro and in vivo degradation and biocompatibility...
May 21, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28529011/the-effect-of-in-vivo-created-vascularized-neurotube-on-peripheric-nerve-regeneration
#2
Abdul Kerim Yapici, Yalcin Bayram, Hakan Akgun, Recep Gumus, Fatih Zor
INTRODUCTION: Creating vascularized nerve conduits for treatment of nerve gaps have been researched, however, these methods need microsurgical anastomosis thereby complicating the nerve repair process. Thus, the concept of vascularized nerve conduits has not popularized up till now. The aim of this study is to evaluate the effects of vascularized and non-vascularized biological conduits on peripheral nerve regeneration. MATERIAL AND METHODS: Following ethical board approval, 15 Sprague-Dawley rats were used in the study...
May 11, 2017: Injury
https://www.readbyqxmd.com/read/28522397/cellulose-acetate-poly-lactic-acid-coaxial-wet-electrospun-scaffold-containing-citalopram-loaded-gelatin-nanocarriers-for-neural-tissue-engineering-applications
#3
Mahdi Naseri-Nosar, Majid Salehi, Shahriar Hojjati-Emami
The current study aimed to develop a biodegradable three-dimensional drug-loaded scaffold with the core-shell structured fibrils using coaxial wet-electrospinning for neural tissue engineering application. Poly lactic acid was wet-electrospun as the core, whereas cellulose acetate was fabricated into the fibril's shell. The scaffold then was coated with citalopram-loaded gelatin nanocarriers (CGNs) produced by nanoprecipitation. Scanning electron microscope observation revealed that the fibrils formed a nonwoven structure with the average diameter of ∼950nm...
May 15, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28509699/penis-transplantation-first-us-experience
#4
Curtis L Cetrulo, Kai Li, Harry M Salinas, Matthew D Treiser, Ilse Schol, Glen W Barrisford, Francis J McGovern, Adam S Feldman, Michael T Grant, Cigdem Tanrikut, Jeffrey H Lee, Richard J Ehrlichman, Paul W Holzer, Garry M Choy, Raymond W Liu, Zhi Yang Ng, Alexandre G Lellouch, Josef M Kurtz, William G Austen, Jonathan M Winograd, Branko Bojovic, Kyle R Eberlin, Ivy A Rosales, Robert B Colvin, Dicken S C Ko
OBJECTIVE: We describe the first successful penis transplant in the United States in a patient with a history of subtotal penectomy for penile cancer. BACKGROUND: Penis transplantation represents a new paradigm in restoring anatomic appearance, urine conduit, and sexual function after genitourinary tissue loss. To date, only 2 penis transplants have been performed worldwide. METHODS: After institutional review board approval, extensive medical, surgical, and radiological evaluations of the patient were performed...
May 15, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28485084/electrospun-silk-fibroin-based-neural-scaffold-for-bridging-a-long-sciatic-nerve-gap-in-dogs
#5
Chengbin Xue, Hui Zhu, Dehua Tan, Hechun Ren, Xiaokun Gu, Yahong Zhao, Ping Zhang, Zhichao Sun, Yumin Yang, Jianhui Gu, Yun Gu, Xiaosong Gu
Silk fibroin (SF) derived silkworms represent a type of highly biocompatible biomaterial for tissue engineering. We have previously investigated biocompatibility of silk fibroin with neural cells isolated from central nervous system or peripheral nerve system in vitro, and also developed a SF-based nerve graft conduit (NGC) or tissue engineered nerve grafts (TENGs) by introducing bone marrow mesenchymal stem cells (BMSCs), as support cells, into SF-based scaffold and evaluated the outcomes of peripheral nerve repair in rat model...
May 9, 2017: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/28479468/a-ten-year-experience-using-a-hybrid-endovascular-approach-to-treat-aberrant-subclavian-arterial-aneurysms
#6
Mathew Wooster, Martin Back, Danielle Sutzko, Hollie Gaeto, Paul Armstrong, Murray Shames
BACKGROUND: To describe a single center experience using combined extra-anatomic open arch branch revascularization with aortic arch endovascular exclusion for treatment of aberrant subclavian artery aneurysms. METHODS: All patients undergoing management of aberrant subclavian aneurysms were identified from a prospective patient registry. Means of revascularization included carotid-subclavian bypass or subclavian transposition and origin occlusion was performed by surgical ligation or endovascular embolization at surgeon discretion...
May 4, 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28473159/the-role-of-nerve-graft-substitutes-in-motor-and-mixed-motor-sensory-peripheral-nerve-injuries
#7
REVIEW
Nadia Rbia, Alexander Y Shin
Alternatives to nerve autograft have been invented and approved for clinical use. The reported outcomes of these alternatives in mixed motor nerve repair in humans are scarce and marked by wide variabilities. The purpose of our Current Concepts review is to provide an evidence-based overview of the effectiveness of nerve conduits and allografts in motor and mixed sensory/motor nerve reconstruction. Nerve graft substitutes have good outcomes in mixed/motor nerves in gaps less than 6 mm and internal diameters between 3 and 7 mm...
May 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28443569/can-a-small-intestine-segment-be-an-alternative-biological-conduit-for-peripheral-nerve-regeneration
#8
Mehmet S Arda, Emre A Koçman, Emre Özkara, Erdem Söztutar, Orhan Özatik, Aydan Köse, Cengiz Çetin
BACKGROUND: Autologous nerve grafts (ANG) are used to bridge peripheral nerve defects. Limited sources and donor site morbidity are the major problems of peripheral nerve grafts. Although various types of autologous grafts such as arteries, veins and muscles have been recommended, an ideal conduit has not been described yet. AIMS: The purpose of present study is to investigate the effectiveness of small intestinal conduit (SIC) for peripheral nerve defects. STUDY DESIGN: Animal experimentation...
April 6, 2017: Balkan Medical Journal
https://www.readbyqxmd.com/read/28412554/prompt-peripheral-nerve-regeneration-induced-by-a-hierarchically-aligned-fibrin-nanofiber-hydrogel
#9
Jinrong Du, Jianheng Liu, Shenglian Yao, Haiquan Mao, Jiang Peng, Xun Sun, Zheng Cao, Yongdong Yang, Bo Xiao, Yiguo Wang, Peifu Tang, Xiumei Wang
Fibrin plays a crucial role in peripheral nerve regeneration, which could occur spontaneously in the format of longitudinally oriented fibrin cables during the initial stage of nerve regeneration. This fibrin cable can direct migration and proliferation of Schwann cells and axonal regrowth, which is very important to nerve regeneration. In the present study, we prepared a three-dimensional hierarchically aligned fibrin nanofiber hydrogel (AFG) through electrospinning and molecular self-assembly to resemble the architecture and biological function of the native fibrin cable...
April 12, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28406608/functionalized-carbon-nanotube-and-graphene-oxide-embedded-electrically-conductive-hydrogel-synergistically-stimulates-nerve-cell-differentiation
#10
Xifeng Liu, A Lee Miller, Sungjo Park, Brian E Waletzki, Zifei Zhou, Andre Terzic, Lichun Lu
Nerve regeneration after injury is a critical medical issue. In previous work, we have developed an oligo(poly(ethylene glycol) fumarate) (OPF) hydrogel incorporated with positive charges as a promising nerve conduit. In this study, we introduced cross-linkable bonds to graphene oxide and carbon nanotube to obtain the functionalized graphene oxide acrylate (GOa) and carbon nanotube poly(ethylene glycol) acrylate (CNTpega). An electrically conductive hydrogel was then fabricated by covalently embedding GOa and CNTpega within OPF hydrogel through chemical cross-linking followed by in situ reduction of GOa in l-ascorbic acid solution...
April 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28406160/morphological-detection-and-functional-assessment-of-regenerated-nerve-after-neural-prosthesis-with-a-pgla-nerve-conduit
#11
Dong Gao, Jun-Jian Jiang, Shi-Hui Gu, Jiu-Zhou Lu, Lei Xu
This study aimed to observe the morphological characteristics of a PGLA [poly(glycolide-co-L-lactide)] nerve conduit and regenerated nerve bundle in the human body using high-frequency ultrasound and examine functional recovery of the regenerated nerve using functional magnetic resonance imaging (fMRI) after neural prosthesis with a PGLA nerve conduit. Thirty-nine patients underwent high-frequency ultrasound, and one patient with superficial radial nerve injury (27-mm defect) underwent fMRI at one, three, and six postoperative months...
April 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28401914/a-3d-engineered-porous-conduit-for-peripheral-nerve-repair
#12
Jie Tao, Yu Hu, Shujuan Wang, Jiumeng Zhang, Xuan Liu, Zhiyuan Gou, Hao Cheng, Qianqi Liu, Qianqian Zhang, Shenglan You, Maling Gou
End-to-end neurorrhaphy is the most commonly used method for treating peripheral nerve injury. However, only 50% of patients can regain useful function after treating with neurorrhaphy. Here, we constructed a 3D-engineered porous conduit to promote the function recovery of the transected peripheral nerve after neurorrhaphy. The conduit that consisted of a gelatin cryogel was prepared by molding with 3D-printed moulds. Due to its porous structure and excellent mechanical properties, this conduit could be collapsed by the mechanical force and resumed its original shape after absorption of normal saline...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28395576/recovery-of-mechanical-detection-thresholds-after-direct-digital-nerve-repair-versus-conduit-implantation
#13
J L Huber, C Maier, T Mainka, L Mannil, J Vollert, H-H Homann
The purpose of this study was to assess sensory and functional nerve recovery after digital nerve injury in patients with an end-to-end suture (S) or with implantation of a collagen conduit (C) to bridge a nerve gap. Fifteen S and 11 C with a follow-up of 6-36 months and 28 healthy control participants were enrolled. Methods of assessments were quantitative sensory testing, the Disabilities of the Arm, Shoulder and Hand questionnaire (DASH), range of motion and the painDetect questionnaire. After both procedures, sensory profiles showed largely recovered function of C and Aδ fibres but severe loss of Aβ-fibre function leading to increased mechanical detection thresholds...
April 1, 2017: Journal of Hand Surgery, European Volume
https://www.readbyqxmd.com/read/28391036/design-and-optimization-of-a-biodegradable-porous-zein-conduit-using-microtubes-as-a-guide-for-rat-sciatic-nerve-defect-repair
#14
Guo-Wu Wang, Hui Yang, Wei-Feng Wu, Ping Zhang, Jin-Ye Wang
Various degradable biomaterials have been used to bridge injured peripheral nerve defect; however, drawbacks such as poor mechanical properties, inappropriate degradation rate, and toxic degradation products continue to limit the application of them in nerve repair. Considering the unique properties of zein, such as its biocompatibility, biodegradability and ease of fabrication, we report the use of zein conduits to repair injured rat sciatic nerves with a 10-mm defect. Three-dimensional zein conduits were designed with/without pores, and with/without microtubes including in the lumen of conduits...
July 2017: Biomaterials
https://www.readbyqxmd.com/read/28389905/fibrin-glue-as-a-stabilization-strategy-in-peripheral-nerve-repair-when-using-porous-nerve-guidance-conduits
#15
Divya Bhatnagar, Jared S Bushman, N Sanjeeva Murthy, Antonio Merolli, Hilton M Kaplan, Joachim Kohn
Porous conduits provide a protected pathway for nerve regeneration, while still allowing exchange of nutrients and wastes. However, pore sizes >30 µm may permit fibrous tissue infiltration into the conduit, which may impede axonal regeneration. Coating the conduit with Fibrin Glue (FG) is one option for controlling the conduit's porosity. FG is extensively used in clinical peripheral nerve repair, as a tissue sealant, filler and drug-delivery matrix. Here, we compared the performance of FG to an alternative, hyaluronic acid (HA) as a coating for porous conduits, using uncoated porous conduits and reverse autografts as control groups...
May 2017: Journal of Materials Science. Materials in Medicine
https://www.readbyqxmd.com/read/28371231/chitosan-conduits-filled-with-simvastatin-pluronic-f-127-hydrogel-promote-peripheral-nerve-regeneration-in-rats
#16
Qi Guo, Can Liu, Bao Hai, Teng Ma, Wen Zhang, Jie Tan, Xin Fu, Hong Wang, Yingsheng Xu, Chunli Song
Treating peripheral nerve defects represents a clinical challenge, and nerve conduits lacking an internal scaffold lead to limited large nerve gap regeneration. Here, we bridged 10-mm sciatic nerve defects in rats with a chitosan conduit filled with 0, 0.5, or 1.0 mg of simvastatin in Pluronic F-127 hydrogel. We assessed subsequent nerve regeneration using the sciatic functional index (SFI), electrophysiological assessments, Fluoro-Gold (FG) retrograde tracing, gastrocnemius muscle mass measurements, and histological and immunohistochemical assessments of nerve regeneration...
April 3, 2017: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
https://www.readbyqxmd.com/read/28362971/stabilization-rolling-and-addition-of-other-extracellular-matrix-proteins-to-collagen-hydrogels-improve-regeneration-in-chitosan-guides-for-long-peripheral-nerve-gaps-in-rats
#17
Francisco Gonzalez-Perez, Stefano Cobianchi, Claudia Heimann, James B Phillips, Esther Udina, Xavier Navarro
BACKGROUND: Autograft is still the gold standard technique for the repair of long peripheral nerve injuries. The addition of biologically active scaffolds into the lumen of conduits to mimic the endoneurium of peripheral nerves may increase the final outcome of artificial nerve devices. Furthermore, the control of the orientation of the collagen fibers may provide some longitudinal guidance architecture providing a higher level of mesoscale tissue structure. OBJECTIVE: To evaluate the regenerative capabilities of chitosan conduits enriched with extracellular matrix-based scaffolds to bridge a critical gap of 15 mm in the rat sciatic nerve...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28360885/circadian-rhythm-influences-the-promoting-role-of-pulsed-electromagnetic-fields-on-sciatic-nerve-regeneration-in-rats
#18
Shu Zhu, Jun Ge, Zhongyang Liu, Liang Liu, Da Jing, Mingzi Ran, Meng Wang, Liangliang Huang, Yafeng Yang, Jinghui Huang, Zhuojing Luo
Circadian rhythm (CR) plays a critical role in the treatment of several diseases. However, the role of CR in the treatment of peripheral nerve defects has not been studied. It is also known that the pulsed electromagnetic fields (PEMF) can provide a beneficial microenvironment to quicken the process of nerve regeneration and to enhance the quality of reconstruction. In this study, we evaluate the impact of CR on the promoting effect of PEMF on peripheral nerve regeneration in rats. We used the self-made "collagen-chitosan" nerve conduits to bridge the 15-mm nerve gaps in Sprague-Dawley rats...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28344529/clinical-evaluation-after-peripheral-nerve-repair-with-caprolactone-neurotube
#19
Gabriel Costa Serrão de Araújo, Bernardo Couto Neto, Renato Harley Santos Botelho, Marcio Carpi Malta
Background: Peripheral nerve injuries with substance loss are challenges to surgeons because direct suture repair may result in malfunction due to nerve suture tension. Autologous nerve grafts are alternatives for treating those lesions; however, harvesting grafts adds morbidity at donor sites. Synthetic substitutes are options to bridge the gaps in these situations. The caprolactone neurotubes are used to assist nerve regeneration, but the literature lacks studies that evaluate their results. Methods: This research was designed to clinically evaluate patients undergoing repair of peripheral nerves with that conduit...
March 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28336306/efficacy-of-acellular-nerve-allografts-in-trigeminal-nerve-reconstruction
#20
Andrew Yampolsky, Vincent Ziccardi, Sung-Kiang Chuang
PURPOSE: During trigeminal nerve repair, a gap is sometimes encountered that prevents the tension-free apposition of nerve endings. The use of a processed acellular nerve allograft is a novel technique that shows promise in overcoming this problem. The goal of the present study was to support the slowly evolving body of evidence that acellular processed nerve allografts (Avance; Axogen, Alachua, FL) are a viable alternative to autogenous nerve grafting and the use of conduits for reconstructing defects of the trigeminal nerve...
February 27, 2017: Journal of Oral and Maxillofacial Surgery
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