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https://www.readbyqxmd.com/read/28527139/exploration-of-an-innovative-draw-solution-for-a-forward-osmosis-membrane-distillation-desalination-process
#1
Nguyen Cong Nguyen, Shiao-Shing Chen, Shubham Jain, Hau Thi Nguyen, Saikat Sinha Ray, Huu Hao Ngo, Wenshan Guo, Ngoc Tuan Lam, Hung Cong Duong
Forward osmosis (FO) has emerged as a viable technology to alleviate the global water crisis. The greatest challenge facing the application of FO technology is the lack of an ideal draw solution with high water flux and low reverse salt flux. Hence, the objective of this study was to enhance FO by lowering reverse salt flux and maintaining high water flux; the method involved adding small concentrations of Al2(SO4)3 to a MgCl2 draw solution. Results showed that 0.5 M MgCl2 mixed with 0.05 M of Al2(SO4)3 at pH 6...
May 19, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28526246/impaired-mitophagy-facilitates-mitochondrial-damage-in-danon-disease
#2
Sherin I Hashem, Anne N Murphy, Ajit S Divakaruni, Matthew L Klos, Bradley C Nelson, Emily C Gault, Teisha J Rowland, Cynthia N Perry, Yusu Gu, Nancy D Dalton, William H Bradford, Eric J Devaney, Kirk L Peterson, Kenneth L Jones, Matthew R G Taylor, Ju Chen, Neil C Chi, Eric D Adler
RATIONALE: Lysosomal associated membrane protein type-2 (LAMP-2) is a highly conserved, ubiquitous protein that is critical for autophagic flux. Loss of function mutations in the LAMP-2 gene cause Danon disease, a rare X-linked disorder characterized by developmental delay, skeletal muscle weakness, and severe cardiomyopathy. We previously found that human induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) from Danon patients exhibited significant mitochondrial oxidative stress and apoptosis...
May 16, 2017: Journal of Molecular and Cellular Cardiology
https://www.readbyqxmd.com/read/28525882/interfacially-crosslinked-composite-porous-membranes-for-ultrafast-removal-of-anionic-dyes-from-water-through-permeating-adsorption
#3
Cuijing Liu, Liang Cheng, Yifan Zhao, Liping Zhu
The dye wastewater is one of the most difficult industrial wastewaters to treat. It keeps a big challenge to realize fast removal of dyes from water by membrane filtration due to the trade-off between separation selectivity and permeation flux for ultrafiltration or nanofiltration (NF) process. Here we report novel composite porous membranes which can remove anionic dyes from water by ultrafast permeating adsorption. A crosslinked polyethyleneimine (PEI) polymer with strong adsorption ability was incorporated onto a nylon microfiltration membrane by the interfacial amidation reaction between PEI and trimesoyl chloride...
April 12, 2017: Journal of Hazardous Materials
https://www.readbyqxmd.com/read/28525376/exploiting-ros-and-metabolic-differences-to-kill-cisplatin-resistant-lung-cancer
#4
Medhi Wangpaichitr, Chunjing Wu, Ying Ying Li, Dan J M Nguyen, Hande Kandemir, Sumedh Shah, Shumei Chen, Lynn G Feun, Jeffrey S Prince, Macus T Kuo, Niramol Savaraj
Cisplatin resistance remains a major problem in the treatment of lung cancer. We have discovered that cisplatin resistant (CR) lung cancer cells, regardless of the signaling pathway status, share the common parameter which is an increase in reactive oxygen species (ROS) and undergo metabolic reprogramming. CR cells were no longer addicted to the glycolytic pathway, but rather relied on oxidative metabolism. They took up twice as much glutamine and were highly sensitive to glutamine deprivation. Glutamine is hydrolyzed to glutamate for glutathione synthesis, an essential factor to abrogate high ROS via xCT antiporter...
May 2, 2017: Oncotarget
https://www.readbyqxmd.com/read/28524237/in-vitro-dialysis-of-cytokine-rich-plasma-with-high-and-medium-cut-off-membranes-reduces-its-procalcific-activity
#5
Kevin Willy, Michael Hulko, Markus Storr, Rose Speidel, Julia Gauss, Ralf Schindler, Daniel Zickler
Recently developed high-flux (HF) dialysis membranes with extended permeability provide better clearance of middle-sized molecules such as interleukins (ILs). Whether this modulation of inflammation influences the procalcific effects of septic plasma on vascular smooth muscle cells (VSMCs) is not known. To assess the effects of high cut-off (HCO) and medium cut-off (MCO) membranes on microinflammation and in vitro vascular calcification we developed a miniature dialysis model. Plasma samples from lipopolysaccharide-spiked blood were dialyzed with HF, HCO, and MCO membranes in an in vitro miniature dialysis model...
May 19, 2017: Artificial Organs
https://www.readbyqxmd.com/read/28523012/growth-and-accumulation-of-secondary-metabolites-in-perilla-as-affected-by-photosynthetic-photon-flux-density-and-electrical-conductivity-of-the-nutrient-solution
#6
Na Lu, Emmanuel L Bernardo, Chayanit Tippayadarapanich, Michiko Takagaki, Natsuko Kagawa, Wataru Yamori
The global demand for medicinal plants is increasing. The quality of plants grown outdoors, however, is difficult to control. Myriad environmental factors influence plant growth and directly impact biosynthetic pathways, thus affecting the secondary metabolism of bioactive compounds. Plant factories use artificial lighting to increase the quality of medicinal plants and stabilize production. Photosynthetic photon flux density (PPFD) and electrical conductivity (EC) of nutrient solutions are two important factors that substantially influence perilla (Perilla frutescens, Labiatae) plant growth and quality...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28520776/proteomic-analysis-of-tea-plants-camellia-sinensis-with-purple-young-shoots-during-leaf-development
#7
Qiongqiong Zhou, Zhidan Chen, Jinwook Lee, Xinghui Li, Weijiang Sun
Tea products made from purple leaves are highly preferred by consumers due to the health benefits. This study developed a proteome reference map related to color changes during leaf growth in tea (Camellia sinensis) plant with purple young shoots using two-dimensional electrophoresis (2-DE). Forty-six differentially expressed proteins were detected in the gel and successfully identified by using MALDI-TOF/TOF-MS. The pronounced changes in the proteomic profile between tender purple leaves (TPL) and mature green leaves (MGL) included: 1) the lower activity of proteins associated with CO2 assimilation, energy metabolism and photo flux efficiency and higher content of anthocyanins in TPL than those in MGL may protect tender leaves against photo-damage; 2) the higher abundance of chalcone synthase (CHS), chalcone isomerase (CHI) and flavonol synthase (FLS) likely contributes to the synthesis of anthocyanins, catechins and flavonols in TPL tissues; 3) higher abundance of stress response proteins, such as glutathione S-transferases (GST) and phospholipid hydroperoxide glutathione peroxidase (PHGPx), could enhance the tolerance of TPL tissues to adverse condition in; and 4) the increased abundance of proteins related to protein synthesis, nucleic acids and cell wall proteins should be beneficial for the proliferation and expansion of leaf cell in TPL tissues...
2017: PloS One
https://www.readbyqxmd.com/read/28516989/the-effect-of-anions-on-the-electrochemical-properties-of-polyaniline-for-supercapacitors
#8
Ji Xing, Maoying Liao, Chi Zhang, Min Yin, Dongdong Li, Ye Song
To investigate the effect of anions on the electrochemical properties of polyaniline (PANI) for supercapacitors, electrochemical performance tests of PANI with different dopant anions were carried out in the corresponding acid solutions by cyclic voltammetry (CV) and galvanostatic charge-discharge (GCD) methods. In particular, ionic fluxes and solvent molecules involved in redox processes can be analyzed by the electrochemical quartz crystal microbalance (EQCM) technique and discriminated by simultaneously recording cyclic voltammograms and mass changes during redox switching...
May 18, 2017: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/28515906/measurement-accuracy-of-total-cell-volume-by-automated-dialyzer-reprocessing-a-prospective-cohort-study
#9
Chatchai Kreepala, Aroonchai Sangpanich, Phirudee Boonchoo, Warit Rungsrithananon
INTRODUCTION: Dialyzer reprocessing machines have replaced human labor in preparing re-usable dialyzers. It also made the process of total cell volume (TCV) measurement become faster. Nevertheless, there has been a lack of data on efficacy of weight evaluation on TCV by machine compared to volume evaluation by the conventional method. The aim of this study was to evaluate the efficacy of TCV measurement performed by Kidney-Kleen(®) reprocessing machine, produced by MEDITOP Company in Thailand, compared to that of the conventional method...
June 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28515537/estimating-spatially-distributed-turbulent-heat-fluxes-from-high-resolution-thermal-imagery-acquired-with-a-uav-system
#10
Claire Brenner, Christina Elisabeth Thiem, Hans-Dieter Wizemann, Matthias Bernhardt, Karsten Schulz
In this study, high-resolution thermal imagery acquired with a small unmanned aerial vehicle (UAV) is used to map evapotranspiration (ET) at a grassland site in Luxembourg. The land surface temperature (LST) information from the thermal imagery is the key input to a one-source and two-source energy balance model. While the one-source model treats the surface as a single uniform layer, the two-source model partitions the surface temperature and fluxes into soil and vegetation components. It thus explicitly accounts for the different contributions of both components to surface temperature as well as turbulent flux exchange with the atmosphere...
May 19, 2017: International Journal of Remote Sensing
https://www.readbyqxmd.com/read/28515456/metabolomic-analysis-shows-differential-hepatic-effects-of-t2-and-t3-in-rats-after-short-term-feeding-with-high-fat-diet
#11
Liliana F Iannucci, Federica Cioffi, Rosalba Senese, Fernando Goglia, Antonia Lanni, Paul M Yen, Rohit A Sinha
Nonalcoholic fatty liver disease (NAFLD) is a major health problem worldwide, and is often associated with lipotoxic injury, defective mitochondrial function, and insulin resistance. Thyroid hormones (THs) are important regulators of hepatic lipid metabolism. Among the THs, diiodothyronine (T2) and triiodothyronine (T3) have shown promising results in lowering hepatic fat content in various models of NAFLD. In this study, we used a targeted metabolomics approach to investigate the differential effects of T2 and T3 on the early metabolic adaptation in the livers of rats fed high fat diet (HFD), a period when hepatosteatosis is reversible...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28515174/functional-assessment-of-sodium-chloride-co-transporter-ncc-mutants-in-polarized-mammalian-epithelial-cells
#12
Lena Lindtoft Rosenbaek, Federica Rizzo, Nanna MacAulay, Olivier Staub, Robert A Fenton
The thiazide-sensitive sodium chloride co-transporter, NCC, is important for maintaining serum sodium (Na+) and, indirectly, serum potassium (K+) levels. Functional studies on NCC have used cell lines with native NCC expression, transiently transfected non-polarized cell lines or Xenopus laevis oocytes. Here, we developed polarized Madin-Darby canine kidney type I (MDCKI) mammalian epithelial cell lines with tetracycline-inducible human NCC expression to study NCC activity and membrane abundance in the same system...
May 17, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/28512556/pediatric-tuberculosis-in-northern-sardinia
#13
Maria Grazia Clemente, Elena Dore, Lidia Abis, Paola Molicotti, Stefania Zanetti, Paolina Olmeo, Roberto Antonucci
BACKGROUND AND OBJECTIVES: Migration flux is an increasing phenomenon in Italy, and it raises several public health issues and concerns in pediatric infectious diseases. This study investigated the clinical characteristics and outcomes of a pediatric population at high-risk for tuberculosis (TB) and the potential role of immigration as a risk factor. DESIGN: We performed an observational retrospective study of children referred to the only Pediatric Infectious Diseases Unit for Northern Sardinia over a 6-year-period (2009-2014)...
2017: Mediterranean Journal of Hematology and Infectious Diseases
https://www.readbyqxmd.com/read/28512330/direct-evaluation-of-influence-of-electron-damage-on-the-subcell-performance-in-triple-junction-solar-cells-using-photoluminescence-decays
#14
David M Tex, Tetsuya Nakamura, Mitsuru Imaizumi, Takeshi Ohshima, Yoshihiko Kanemitsu
Tandem solar cells are suited for space applications due to their high performance, but also have to be designed in such a way to minimize influence of degradation by the high energy particle flux in space. The analysis of the subcell performance is crucial to understand the device physics and achieve optimized designs of tandem solar cells. Here, the radiation-induced damage of inverted grown InGaP/GaAs/InGaAs triple-junction solar cells for various electron fluences are characterized using conventional current-voltage (I-V) measurements and time-resolved photoluminescence (PL)...
May 16, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28512019/novel-inulin-based-mucoadhesive-micelles-loaded-with-corticosteroids-as-potential-transcorneal-permeation-enhancers
#15
Giulia Di Prima, Silvia Saladino, Flavia Bongiovì, Giorgia Adamo, Giulio Ghersi, Giovanna Pitarresi, Gaetano Giammona
In this work a new copolymer of inulin (INU) derivatized with ethylendiamine (EDA) and retinoic acid (RA), named INU-EDA-RA, was synthetized, characterized and employed to produce micelles as carriers for topical administration of corticosteroids for the potential treatment of diseases of posterior eye segment. Spectroscopic analysis confirmed a molar derivatization degree of 11.30 and 4.30 % in EDA and RA, respectively. INU-EDA-RA micelles are capable of strong mucoadhesive interactions which result time-independent and stable over time but concentration depending...
May 13, 2017: European Journal of Pharmaceutics and Biopharmaceutics
https://www.readbyqxmd.com/read/28510453/influence-of-local-heating-on-marangoni-flows-and-evaporation-kinetics-of-pure-water-drops
#16
Alexandros Askounis, Yutaku Kita, Masamichi Kohno, Yasuyuki Takata, Vasileios Koutsos, Khellil Sefiane
The effect of localized heating on the evaporation of pure sessile water drops was probed experimentally by a combination of infrared thermography and optical imaging. In particular, we studied the effect of three different heating powers and two different locations, directly below the center and edge of the drop. In all cases, four distinct stages were identified according to the emerging thermal patterns. In particular, depending on heating location, recirculating vortices emerge which either remain pinned or move azimuthally within the drop...
May 16, 2017: Langmuir: the ACS Journal of Surfaces and Colloids
https://www.readbyqxmd.com/read/28510224/dna-supercoiling-is-a-fundamental-regulatory-principle-in-the-control-of-bacterial-gene-expression
#17
REVIEW
Charles J Dorman, Matthew J Dorman
Although it has become routine to consider DNA in terms of its role as a carrier of genetic information, it is also an important contributor to the control of gene expression. This regulatory principle arises from its structural properties. DNA is maintained in an underwound state in most bacterial cells and this has important implications both for DNA storage in the nucleoid and for the expression of genetic information. Underwinding of the DNA through reduction in its linking number potentially imparts energy to the duplex that is available to drive DNA transactions, such as transcription, replication and recombination...
September 2016: Biophysical Reviews
https://www.readbyqxmd.com/read/28510219/the-dynamic-interplay-between-dna-topoisomerases-and-dna-topology
#18
REVIEW
Yeonee Seol, Keir C Neuman
Topological properties of DNA influence its structure and biochemical interactions. Within the cell, DNA topology is constantly in flux. Transcription and other essential processes, including DNA replication and repair, not only alter the topology of the genome but also introduce additional complications associated with DNA knotting and catenation. These topological perturbations are counteracted by the action of topoisomerases, a specialized class of highly conserved and essential enzymes that actively regulate the topological state of the genome...
November 2016: Biophysical Reviews
https://www.readbyqxmd.com/read/28510216/dna-supercoiling-is-a-fundamental-regulatory-principle-in-the-control-of-bacterial-gene-expression
#19
REVIEW
Charles J Dorman, Matthew J Dorman
Although it has become routine to consider DNA in terms of its role as a carrier of genetic information, it is also an important contributor to the control of gene expression. This regulatory principle arises from its structural properties. DNA is maintained in an underwound state in most bacterial cells and this has important implications both for DNA storage in the nucleoid and for the expression of genetic information. Underwinding of the DNA through reduction in its linking number potentially imparts energy to the duplex that is available to drive DNA transactions, such as transcription, replication and recombination...
November 2016: Biophysical Reviews
https://www.readbyqxmd.com/read/28509531/hierarchical-porous-structured-sio2-sno2-nanofibrous-membrane-with-superb-flexibility-for-molecular-filtration
#20
Haoru Shan, Xueqin Wang, Feihao Shi, Jianhua Yan, Jianyong Yu, Bin Ding
The separation and purification of chemical molecules from organic media under harsh chemical environments is of vital importance in the fields such as water treatment, biomedical engineering, and organic recycling. Herein, we report the preparation of a flexible SiO2/SnO2 nanofibrous membrane (SiO2/SnO2 NFM) with high surface area and hierarchical porous structure by selecting poly (vinyl butyral) as pore-forming agent and embedding crystalline phase into amorphous matrix without using surfactant as sacrificial template or special heat treatment...
May 16, 2017: ACS Applied Materials & Interfaces
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