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Aravind Cherukuri

Rajil Mehta, Sushma Bhusal, Parmjeet Randhawa, Puneet Sood, Aravind Cherukuri, Christine Wu, Chethan Puttarajappa, William Hoffman, Nirav Shah, Massimo Mangiola, Adriana Zeevi, Amit D Tevar, Sundaram Hariharan
The impact of subclinical inflammation (SCI) noted on early kidney allograft biopsies remains unclear. This study evaluated the outcome of SCI noted on 3-month biopsy. A total of 273/363 (75%) kidney transplant recipients with a functioning kidney underwent allograft biopsies 3-months posttransplant. Among those with stable allograft function at 3 months, 200 biopsies that did not meet the Banff criteria for acute rejection were identified. These were Group I: No Inflammation (NI, n = 71) and Group II: Subclinical Inflammation (SCI, n = 129)...
December 15, 2017: American Journal of Transplantation
Aravind Cherukuri, Alan D Salama, Clive R Carter, Douglas Landsittel, Gururaj Arumugakani, Brendan Clark, David M Rothstein, Richard J Baker
Human transitional B cells express relatively high IL-10 and low TNF-α levels, which correlate with B regulatory activity in vitro. Herein, we aim to further define B regulatory phenotype and determine whether B regulatory activity can serve as a prognostic marker for renal allograft dysfunction (graft loss or 2-fold fall in estimated glomerular filtration rate). Transitional B cells can be divided into T1 and T2 subsets based on surface phenotype. T1 cells express a significantly higher ratio of IL-10 to TNF-α than T2 cells or other B subsets...
January 2017: Kidney International
Aravind Cherukuri, David M Rothstein, Brendan Clark, Clive R Carter, Adam Davison, Maria Hernandez-Fuentes, Eric Hewitt, Alan D Salama, Richard J Baker
Human B cells with immunoregulatory properties in vitro (Bregs) have been defined by the expression of IL-10 and are enriched in various B-cell subsets. However, proinflammatory cytokine expression in B-cell subsets is largely unexplored. We examined the cytokine profiles of human PBMCs and found that subsets of CD24(hi)CD38(hi) transitional B cells (TrBs), CD24(hi)CD27(+) memory B cells, and naïve B cells express IL-10 and the proinflammatory cytokine TNF-α simultaneously. TrBs had the highest IL-10/TNF-α ratio and suppressed proinflammatory helper T cell 1 (Th1) cytokine expression by autologous T cells in vitro more potently than memory B cells did, despite similar IL-10 expression...
July 2014: Journal of the American Society of Nephrology: JASN
Shazia Shabir, Jean-Michel Halimi, Aravind Cherukuri, Simon Ball, Charles Ferro, Graham Lipkin, David Benavente, Philippe Gatault, Richard Baker, Bryce Kiberd, Richard Borrows
BACKGROUND: Accurate prediction of kidney transplant failure remains imperfect. The objective of this study was to develop and validate risk scores predicting 5-year transplant failure, based on data available 12 months posttransplantation. STUDY DESIGN: Development and then independent multicenter validation of risk scores predicting death-censored and overall transplant failure. SETTING & PARTICIPANTS: Outcomes of kidney transplant recipients (n=651) alive with transplant function 12 months posttransplantation in Birmingham, United Kingdom, were used to develop models predicting transplant failure risk 5 years posttransplantation...
April 2014: American Journal of Kidney Diseases: the Official Journal of the National Kidney Foundation
Matthew P Welberry Smith, Aravind Cherukuri, Chas G Newstead, Andrew J P Lewington, Niaz Ahmad, Krish Menon, Stephen G Pollard, Padmini Prasad, Steve Tibble, Emma Giddings, Richard J Baker
BACKGROUND: The use of alemtuzumab as induction immunosuppression for renal transplantation introduces the possibility of long-term tacrolimus monotherapy, avoiding maintenance with both corticosteroids and mycophenolate mofetil (MMF). METHODS: We conducted a single-center, prospective, open-label, randomized controlled trial comparing two steroid avoidance regimens between December 2006 and November 2010. One hundred and sixteen adult patients were randomized to either basiliximab induction followed by tacrolimus and MMF maintenance or to alemtuzumab induction followed by tacrolimus monotherapy...
December 27, 2013: Transplantation
Baljit K Saundh, Richard Baker, Mark Harris, Matt P Welberry Smith, Aravind Cherukuri, Antony Hale
The pathogenesis of BK polyomavirus (BKV) infection and associated nephropathy in renal transplant recipients is not clearly understood. To gain insight, urine and plasma samples were collected from 112 renal transplant recipients before and after transplantation and tested for the presence of BKV by polymerase chain reaction. Detection of BKV infection very early (ie, 5 days) after transplantation was identified as a risk factor for subsequent BKV viremia and BKV-associated nephropathy. Phylogenetic analysis of VP1 sequences with corresponding ethnicity data suggests that reactivation was of donor origin...
January 1, 2013: Journal of Infectious Diseases
Simon W Lines, Aravind Cherukuri, Stuart D Murdoch, Mark C Bellamy, Andrew J P Lewington
INTRODUCTION: Acute kidney injury (AKI) is common among critically ill patients and associated with a high mortality. We report here on the outcomes of patients with AKI who received renal replacement therapy (RRT) on our intensive care unit (ICU). We were interested in which parameters measured at the time of ICU admission were predictive of mortality and the long term renal sequelae for these patients. PATIENTS AND METHODS: All ICU patients in a large UK teaching hospital who received RRT for AKI over a 6-year period were identified and reviewed retrospectively...
January 2011: International Journal of Artificial Organs
Manil Subesinghe, Aravind Cherukuri, Clare Ecuyer, Richard James Baker
Current guidelines are vague in their recommendations as to which patients should be imaged prior to renal transplantation and the optimal imaging modality for this purpose. Data on 112 patients who underwent pre-transplant vascular imaging (magnetic resonance angiography or contrast angiography), from a total of 167 evaluated between January 2005 and October 2006, were scrutinized to see whether abnormal results altered clinical management. Several variables were analyzed to determine possible predictors of an abnormal scan result...
January 2011: Clinical Transplantation
Aravind Cherukuri, Matthew P Welberry-Smith, James E Tattersall, Niaz Ahmad, Chas G Newstead, Andrew J P Lewington, Richard J Baker
BACKGROUND: Late-onset proteinuria after renal transplantation has been universally associated with poor allograft outcomes. However, the significance of early low-grade posttransplant proteinuria remains uncertain. METHODS: We analyzed the effect of proteinuria 3 months posttransplantation on death-censored graft loss, death with a functioning graft, vascular events within the graft's life, and estimated glomerular filtration rate at 5 years. Four hundred seventy-seven renal transplants from a single center (1988-2003) with a mean follow-up of 122 months were divided into four groups based on the median protein creatinine ratio (PCR) during the 3rd posttransplant month (PCR<0...
January 27, 2010: Transplantation
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