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https://www.readbyqxmd.com/read/27909264/global-ablation-of-the-mitochondrial-calcium-uniporter-increases-glycolysis-in-cortical-neurons-subjected-to-energetic-stressors
#1
Matthew Nichols, Pia A Elustondo, Jordan Warford, Aruloli Thirumaran, Evgeny V Pavlov, George S Robertson
The effects of global mitochondrial calcium (Ca(2+)) uniporter (MCU) deficiency on hypoxic-ischemic (HI) brain injury, neuronal Ca(2+) handling, bioenergetics and hypoxic preconditioning (HPC) were examined. Forebrain mitochondria isolated from global MCU nulls displayed markedly reduced Ca(2+) uptake and Ca(2+)-induced opening of the membrane permeability transition pore. Despite evidence that these effects should be neuroprotective, global MCU nulls and wild-type (WT) mice suffered comparable HI brain damage...
December 1, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27882037/uniportal-video-assisted-thoracoscopic-lobectomy-an-alternative-surgical-method-for-pulmonary-carcinoma
#2
Fengwu Lin, Chuan Zhang, Qiang Zhang, Kunpeng Cheng, Yan Zhao
OBJECTIVES: To explore the effects and feasibility of single-port video-assisted thoracic surgery (VATS) on lobectomy for pulmonary carcinoma. METHODS: A total of 67 patients were enrolled in this study, in which 21 patients were treated by single-port VATS (Sing-port Group) and 46 patients by double-port VATS (Double-port Group). Blood loss, duration of thoracic drainage, length of post-operative hospital stay and post-operative pain ratings were compared between the two groups...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27879386/mitochondrial-calcium-homeostasis-implications-for-neurovascular-and-neurometabolic-coupling
#3
REVIEW
Sridhar S Kannurpatti
Mitochondrial function is critical to maintain high rates of oxidative metabolism supporting energy demands of both spontaneous and evoked neuronal activity in the brain. Mitochondria not only regulate energy metabolism, but also influence neuronal signaling. Regulation of "energy metabolism" and "neuronal signaling" (i.e. neurometabolic coupling), which are coupled rather than independent can be understood through mitochondria's integrative functions of calcium ion (Ca(2+)) uptake and cycling. While mitochondrial Ca(2+) do not affect hemodynamics directly, neuronal activity changes are mechanistically linked to functional hyperemic responses (i...
November 22, 2016: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/27876071/bilateral-single-port-thoracoscopic-extended-thymectomy-for-management-of-thymoma-and-myasthenia-gravis-case-report
#4
Francesco Paolo Caronia, Alfonso Fiorelli, Ettore Arrigo, Sebastiano Trovato, Mario Santini, Attilio Ignazio Lo Monte
BACKGROUND: Video-assisted thoracoscopy is become a widely accepted approach for the resection of anterior mediastinal masses, including thymoma. The current trend is to reduce the number of ports and minimize the length of incisions to further decrease postoperative pain, chest wall paresthesia, and length of hospitalization. Herein, we reported an extended resection of thymoma in a patient with myasthenia gravis through an uniportal bilateral thoracoscopic approach. CASE PRESENTATION: A 74 years old woman with myasthenia gravis was referred to our attention for management of a 3...
November 22, 2016: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/27867574/non-grasping-en-bloc-mediastinal-lymph-node-dissection-through-uniportal-video-assisted-thoracic-surgery-for-lung-cancer-surgery
#5
Chengwu Liu, Lin Ma, Chenglin Guo, Lunxu Liu
Uniportal video-assisted thoracic surgery (VATS) has been demonstrated to be feasible, safe, and effective for lung cancer surgery compared with traditional multi-portal VATS. However, complete mediastinal lymph node dissection (MLND) through uniportal VATS is still a difficult work due to more limited access, and most thoracic surgeons use strategies of grasping, accompanied with which are complicated instrumentation and mutual interference among them. To simplify the instrumentation and make MLND more comfortable, we developed the method of "non-grasping en bloc MLND" and applied it during uniportal VATS lung cancer surgery...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27867573/-ipsilateral-high-single-hand-sideways-ruijin-rule-for-camera-assistant-in-uniportal-video-assisted-thoracoscopic-surgery
#6
Taotao Gao, Jie Xiang, Runsen Jin, Yajie Zhang, Han Wu, Hecheng Li
Camera assistant plays a very important role in uniportal video-assisted thoracoscopic surgery (VATS), who acts as the eye of the surgeon, providing the VATS team with a stable and clear operating view. Thus, a good assistant should cooperate with surgeon and manipulate the camera expertly, to ensure eye-hand coordination. We have performed more than 100 uniportal VATS in the Department Of Thoracic Surgery in Ruijin Hospital. Based on our experiences, we summarized the method of holding camera, known as "ipsilateral, high, single-hand, sideways", which largely improves the comfort and fluency of surgery...
October 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27865474/tubeless-uniportal-thoracoscopic-wedge-resection-for-peripheral-lung-nodules
#7
Shun-Mao Yang, Man-Ling Wang, Ming-Hui Hung, Hsao-Hsun Hsu, Ya-Jung Cheng, Jin-Shing Chen
BACKGROUND: Endotracheal intubation and chest tube drainage are considered mandatory for thoracoscopic pulmonary resection. The management of peripheral lung nodules by tubeless uniportal thoracoscopic surgical repair has not been reported previously. METHODS: From October 2015 through January 2016, 30 consecutive patients with peripheral lung nodules underwent uniportal thoracoscopic wedge resection without endotracheal intubation and chest tube drainage (tubeless group)...
November 16, 2016: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/27859782/inhibition-of-the-mitochondrial-calcium-uniporter-mcu-rescues-dopaminergic-neurons-in-pink1-zebrafish
#8
Smijin Soman, Marcus Keatinge, Mahsa Moein, Marc DaCosta, Heather Mortiboys, Alexander Skupin, Sreedevi Sugunan, Michal Bazala, Jacek Kuznicki, Oliver Bandmann
Mutations in PTEN-induced putative kinase 1 (PINK1) are a cause of early onset Parkinson's disease (PD). Loss of PINK1 function causes dysregulation of mitochondrial calcium homeostasis, resulting in mitochondrial dysfunction and neuronal cell death. We report that both genetic and pharmacological inactivation of the mitochondrial calcium uniporter (MCU), located in the inner mitochondrial membrane, prevents dopaminergic neuronal cell loss in pink1(Y431) * mutant zebrafish (Danio rerio) via rescue of mitochondrial respiratory chain function...
November 12, 2016: European Journal of Neuroscience
https://www.readbyqxmd.com/read/27827394/mitochondrial-ca-2-uptake-controls-actin-cytoskeleton-dynamics-during-cell-migration
#9
Julien Prudent, Nikolay Popgeorgiev, Rudy Gadet, Mathieu Deygas, Ruth Rimokh, Germain Gillet
Intracellular Ca(2+) signaling regulates cell migration by acting on cytoskeleton architecture, cell directionality and focal adhesions dynamics. In migrating cells, cytosolic Ca(2+) pool and Ca(2+) pulses are described as key components of these effects. Whereas the role of the mitochondrial calcium homeostasis and the Mitochondria Cacium Uniporter (MCU) in cell migration were recently highlighted in vivo using the zebrafish model, their implication in actin cystokeleton dynamics and cell migration in mammals is not totally characterized...
November 9, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27826570/modified-procedure-of-uniportal-video-assisted-thoracoscopic-lobectomy-with-muscle-sparing-incision
#10
Zhengcheng Liu, Rusong Yang, Feng Shao, Yanqing Pan
BACKGROUND: To describe modified procedure for uniportal video-assisted thoracoscopic surgery (UVATS) lobectomy with a small, total muscle-sparing incision. METHODS: Forty-eight UVATS leucotomy were attempted and successfully completed. A single incision of approximately 3 cm was made in an intercostal space along the anterior axillary line. Muscle-sparing technique was applied with this single-incision approach using muscle sparing technique. RESULTS: Incision size was kept to a minimum, with a median of 3 cm...
October 2016: Annals of Translational Medicine
https://www.readbyqxmd.com/read/27824578/cell-like-p-systems-with-channel-states-and-symport-antiport-rules
#11
Bosheng Song, Linqiang Pan, Mario J Perez-Jimenez
Cell-like P systems with symport/antiport rules are inspired by the structure of a cell and the way of communicating substances through membrane channels between neighboring regions. In this work, channel states are introduced into cell-like P systems with symport/antiport rules, and we call this variant of communication P systems as cell-like P systems with channel states and symport/antiport rules. In such P systems, at most one channel is established between neighboring regions, each channel associates with one state in order to control communication at each step, and rules are used in a sequential manner: on each channel at most one rule can be used at each step...
September 2016: IEEE Transactions on Nanobioscience
https://www.readbyqxmd.com/read/27793988/crispr-cas9-mediated-endogenous-c-terminal-tagging-of-trypanosoma-cruzi-genes-reveals-the-acidocalcisome-localization-of-the-inositol-1-4-5-trisphosphate-receptor
#12
Noelia Lander, Miguel Angel Chiurillo, Melissa Storey, Anibal E Vercesi, Roberto Docampo
Methods for genetic manipulation of Trypanosoma cruzi, the etiologic agent of Chagas disease, have been highly inefficient and no endogenous tagging of genes has been reported to date. We report here the use of the CRISPR (clustered regularly interspaced short palindromic repeats)/Cas9 (CRISPR-associated gene 9) system for endogenously tagging genes in this parasite. The utility of the method was established by tagging genes encoding proteins of known localization such as the flagellar calcium binding protein (TcFCaBP), and the vacuolar proton pyrophosphatase (TcVP1), and two proteins of undefined or disputed localization, the mitochondrial calcium uniporter (TcMCU), and the inositol-1,4,5-trisphosphate receptor (TcIP3R)...
October 28, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27753190/gastrointestinal-methionine-shuttle-priority-handling-of-precious-goods
#13
Lucia Mastrototaro, Gerhard Sponder, Behnam Saremi, Jörg R Aschenbach
Methionine (Met) is a neutral, sulfur-containing, essential amino acid with biological functions in the initiation and prolongation step of protein synthesis, transmethylation reactions, the synthesis of cysteine and cystine, and as a component of antioxidant systems. Its key importance is reflected by the fact that it is usually absorbed from the diet with highest efficiency among all proteinogenic amino acids but may yet not optimally support metabolism and health. As such, crystalline Met supplements are partly used in man and heavily used in production of animal species (poultry, fish, shrimps, pigs and cattle) to provide improved health and performance...
October 17, 2016: IUBMB Life
https://www.readbyqxmd.com/read/27749589/from-biportal-to-uniportal-video-assisted-thoracoscopic-anatomical-lung-resection-a-single-institute-experience
#14
Jia-Ming Chang, Kam-Hong Kam, Yi-Ting Yen, Wei-Li Huang, Wei Chen, Yau-Lin Tseng, Ming-Ho Wu, Wu-Wei Lai, Diego Gonzalez-Rivas
Our study sought to review our experience from biportal to uniportal video-assisted thoracoscopic surgery (VATS) major lung resection. Lessons we learned from the evolution regarding technical aspects were also discussed.We retrospectively reviewed patients who underwent VATS lobectomy or segmentectomies in Ditmanson Medical Foundation Chia-Yi Christian Hospital, Chia-Yi, Taiwan, during January 2012 and December 2014. Patient clinical profiles, surgical indications and procedures, postoperative course, and oncological parameters were analyzed and compared between the biportal and uniportal groups...
October 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27747037/uniportal-video-assisted-thoracoscopic-right-upper-sleeve-lobectomy-and-tracheoplasty-in-a-10-year-old-patient
#15
Diego Gonzalez-Rivas, Jessica Correa Marin, Juan Pablo Ovalle Granados, Juan David Urrea Llano, Sonia Roque Cañas, Alonso Oviedo Arqueta, Mercedes de la Torre
Tracheobronchial pediatric tumors are very rare and procedures like pneumonectomy are seldomly indicated due to the associated morbidity. If a surgical approach is considered, the ideal oncological technique would be the minimally invasive sleeve resection, allowing preservation of lung parenchyma (very important in pediatric patients). Here we present the first report of a thoracoscopic right upper tracheo-bronchial sleeve lobectomy in a pediatric patient. A 10-year-old female patient, who received multiple antibiotic treatments for recurrent pneumonia without improvement, was diagnosed with a right upper lobe (RUL) carcinoid tumor...
September 2016: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/27744718/awake-uniportal-video-assisted-thoracic-surgery-for-complications-after-pneumonectomy
#16
Marcello Migliore, Francesco Borrata, Marco Nardini, Alessandra Criscione, Damiano Calvo, Mariapia Gangemi, Francesco Scalieri
Since 1998, we started a clinical program for awake video-assisted thoracic surgery in our unit using four-step local anesthesia and sedation. Throughout the years, we experienced several difficult cases, three of them had complications postpneumonectomy. The aim of this paper is to report these three cases.
October 17, 2016: Future Oncology
https://www.readbyqxmd.com/read/27732992/surgical-treatment-of-early-l-stage-lung-cancer-what-has-changed-and-what-will-change-in-the-future
#17
Huan H Sun, Joanna Sesti, Jessica S Donington
Recent advances in the surgical treatment of early stage non-small cell lung cancer (NSCLC) have focused heavily on making procedures less invasive, less radical, and better tolerated. Advances in accuracy and increased utilization of cross-sectional imaging allows for diagnosis of smaller and more indolent tumors and preinvasive lesions. Similar to advanced disease, early-stage treatment is now being tailored to individual patients and their tumors. Sublobar resections are gaining acceptance as an oncologically equivalent approach to lobectomy in well-selected stage I patients...
October 2016: Seminars in Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27712092/uniportal-video-assisted-thoracic-surgery-or-single-incision-video-assisted-thoracic-surgery-for-lung-resection-clarifying-definitions
#18
Marcello Migliore, Semih Halezeroglu, Laureano Molins, Dirk Van Raemndonck, Michael R Muller, Federico Rea, Subroto Paul
No abstract text is available yet for this article.
October 7, 2016: Future Oncology
https://www.readbyqxmd.com/read/27692849/calcium-at-the-center-of-cell-signaling-interplay-between-endoplasmic-reticulum-mitochondria-and-lysosomes
#19
REVIEW
Anna Raffaello, Cristina Mammucari, Gaia Gherardi, Rosario Rizzuto
In recent years, rapid discoveries have been made relating to Ca(2+) handling at specific organelles that have important implications for whole-cell Ca(2+) homeostasis. In particular, the structures of the endoplasmic reticulum (ER) Ca(2+) channels revealed by electron cryomicroscopy (cryo-EM), continuous updates on the structure, regulation, and role of the mitochondrial calcium uniporter (MCU) complex, and the analysis of lysosomal Ca(2+) signaling are milestones on the route towards a deeper comprehension of the complexity of global Ca(2+) signaling...
December 2016: Trends in Biochemical Sciences
https://www.readbyqxmd.com/read/27686131/one-thousand-cases-of-tubeless-video-assisted-thoracic-surgery-at-the-rome-tor-vergata-university
#20
Tommaso C Mineo, Alessandro Tamburrini, Gianluca Perroni, Vincenzo Ambrogi
In the early 2000s, the 'Awake Thoracic Surgery Research Group' at Tor Vergata University began a program of thoracic operations in awake nonintubated patients. To our knowledge this was the first program created with this specific purpose. Since then over 1000 tubeless operations have been carried out successfully, making this series one of the widest in the world. Both nononcologic and oncologic conditions were successively approached and major operations for lung cancer are now being performed. Uniportal access was progressively adopted with significant positive outcomes in postoperative recovery, patient acceptance and economical costs...
September 30, 2016: Future Oncology
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