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https://www.readbyqxmd.com/read/29789575/tamoxifen-induced-knockdown-of-the-mitochondrial-calcium-uniporter-in-thy1-expressing-neurons-protects-mice-from-hypoxic-ischemic-brain-injury
#1
Matthew Nichols, Evgeny V Pavlov, George S Robertson
The mitochondrial calcium uniporter (MCU) mediates high-capacity mitochondrial calcium uptake that stimulates energy production. However, excessive MCU activity can cause ischemic heart injury. To examine if the MCU is also involved in hypoxic/ischemic (HI) brain injury, we have generated conditional MCU knockout mice by tamoxifen (TMX) administration to adult MCU-floxed (MCUfl/fl ) mice expressing a construct encoding Thy1-cre/ERT2-eYFP. Relative to TMX/Thy1-cre/ERT2-eYFP controls, HI-induced sensorimotor deficits, forebrain neuron loss and mitochondrial damage were decreased for conditional MCU knockout mice...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29786913/new-insights-into-the-anion-transport-selectivity-and-mechanism-of-tren-based-tris-thio-ureas
#2
Laura Jowett, Ethan Howe, Xin Wu, Nathalie Busschaert, Philip Alan Gale
The anion transport properties of a series of previously reported tren-based anionophores have been revisited using new assays designed to measure anion uniport. This study provides new insights into the transport mechanism and selectivity of this important class of transporters. Specifically, we report the chloride and nitrate transport selectivity of these systems and quantify sulfate transport to determine EC50 values for sulfate transport for the first time. Two new assays were developed to study bicarbonate transport allowing accurate quantification of chloride/bicarbonate exchange...
May 22, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29785295/uniportal-video-assisted-thoracoscopic-segmentectomy
#3
Luis Angel Hernandez-Arenas, Rushmi D Purmessur, Diego Gonzalez-Rivas
Uniportal video-assisted thoracoscopic surgery (VATS) segmentectomy is a technically more complex procedure than uniportal VATS lobectomy, since a detailed comprehension of the segmental anatomy is required. Anatomic sublobar resection can achieve outcomes equivalent to lobectomy in selected patients with stage IA non-small cell lung carcinoma (NSCLC). In this paper we describe our clinical experiences and introduce the technical details of uniportal VATS segmentectomy, including expertise advice ("tips and tricks") in patient selection, positioning and incisions and technical highlights of the most common types of segmentectomies...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29780724/uniportal-vats-lobectomies-masterclass-in-bratislava
#4
Miroslav Janik, Peter Juhos
On February 5-6, an event on uniportal VATS approach to pulmonary resections took place in Bratislava. It focused on developing uniportal VATS technique. The two-day event gave opportunity to discuss the topic with masters of thoracic surgery such as Prof. Hasan Batirel and Diego Gonzalez, to train basic skills on simulators developed by Dr. Tomaz Stupnik and to watch live surgery performed by Diego Gonzalez. Two patients underwent uniportal VATS lobectomy. This event was another step to advance miniinvasive major pulmonary procedures...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29780720/uniportal-video-assisted-thoracic-surgery-treatment-of-intra-operative-complications
#5
Vasilios Tentzeris, Kostas Papagiannopoulos
Background: The uniportal video-assisted thoracic surgery (U-VATS) approach is rapidly gaining attention. Still there is lack of gross engagement to this technique, even within the VATS surgeons. We believe that the uniportal approach needs the same attention as any newly introduced skill; it would be a great mistake to be considered as a simple variation of the standardised multi-portal VATS. Methods: We have evaluated personal and institutional experience, supported by international bibliography...
2018: Journal of Visualized Surgery
https://www.readbyqxmd.com/read/29748369/calcium-signaling-and-reactive-oxygen-species-in-mitochondria
#6
REVIEW
Edoardo Bertero, Christoph Maack
In heart failure, alterations of Na+ and Ca2+ handling, energetic deficit, and oxidative stress in cardiac myocytes are important pathophysiological hallmarks. Mitochondria are central to these processes because they are the main source for ATP, but also reactive oxygen species (ROS), and their function is critically controlled by Ca2+ During physiological variations of workload, mitochondrial Ca2+ uptake is required to match energy supply to demand but also to keep the antioxidative capacity in a reduced state to prevent excessive emission of ROS...
May 11, 2018: Circulation Research
https://www.readbyqxmd.com/read/29748128/the-effects-of-mitochondrial-inhibitors-on-ca-2-signalling-and-electrical-conductances-required-for-pacemaking-in-interstitial-cells-of-cajal-in-the-mouse-small-intestine
#7
Bernard T Drumm, Tae S Sung, Haifeng Zheng, Salah A Baker, Sang D Koh, Kenton M Sanders
Interstitial cells of Cajal (ICC-MY) are pacemakers that generate and propagate electrical slow waves in gastrointestinal (GI) muscles. Slow waves appear to be generated by the release of Ca2+ from intracellular stores and activation of Ca2+ -activated Cl- channels (Ano1). Conduction of slow waves to smooth muscle cells coordinates rhythmic contractions. Mitochondrial Ca2+ handling is currently thought to be critical for ICC pacemaking. Protonophores, inhibitors of the electron transport chain (FCCP, CCCP or antimycin) or mitochondrial Na+ /Ca2+ exchange blockers inhibited slow waves in several GI muscles...
February 1, 2018: Cell Calcium
https://www.readbyqxmd.com/read/29733823/total-r%C3%A4-b-resect%C3%A4-on-v%C3%A4-a-un%C3%A4-portal-thoracoscop%C3%A4-c-approach
#8
Ilhan Ocakcioglu, Nezih Onur Ermerak, Mustafa Yuksel
In this report, we present a case specifying the availability of uniportal thoracoscopic resection of a total rib safely without the need of conventional thoracotomy. The favorable outcome of this case suggests that uniportal thoracoscopic technique described here is safe and succesful approach for resection of costal lesions with good cosmetic results. To our knowledge; this is the first case reporting the entire rib resection via uniportal thoracoscopic approach.
May 4, 2018: Annals of Thoracic Surgery
https://www.readbyqxmd.com/read/29732196/innovative-surgical-endoscopes-in-video-assisted-thoracic-surgery
#9
REVIEW
Truman Cheng, Calvin S H Ng, Zheng Li
In the past three decades, rod lens endoscopes had facilitated the development and wide spread applications of video-assisted thoracic surgery (VATS). With the rise of uniportal VATS in recent years, innovations in surgical instruments should once again complement the advancement in surgical technique. While articulated flexible endoscopes have expand the field of view, and can alter viewing direction with minimal maneuvers, they still suffer from problems like trocar crowding and interference with other instruments...
April 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29721912/a-middle-eastern-founder-mutation-expands-the-genotypic-and-phenotypic-spectrum-of-mitochondrial-micu1-deficiency-a-report-of-13-patients
#10
Sara Musa, Wafaa Eyaid, Kimberli Kamer, Rehab Ali, Mariam Al-Mureikhi, Noora Shahbeck, Fatma Al Mesaifri, Nawal Makhseed, Zakkiriah Mohamed, Wafaa Ali AlShehhi, Vamsi K Mootha, Jane Juusola, Tawfeg Ben-Omran
MICU1 encodes a Ca2+ sensing, regulatory subunit of the mitochondrial uniporter, a selective calcium channel within the organelle's inner membrane. Ca2+ entry into mitochondria helps to buffer cytosolic Ca2+ transients and also activates ATP production within the organelle. Mutations in MICU1 have previously been reported in 17 children from nine families with muscle weakness, fatigue, normal lactate, and persistently elevated creatine kinase, as well as variable features that include progressive extrapyramidal signs, learning disabilities, nystagmus, and cataracts...
May 3, 2018: JIMD Reports
https://www.readbyqxmd.com/read/29707805/intestinal-absorption-of-glucose-in-mice-as-determined-by-positron-emission-tomography
#11
Monica Sala-Rabanal, Chiara Ghezzi, Bruce A Hirayama, Vladimir Kepe, Jie Liu, Jorge R Barrio, Ernest M Wright
KEY POINTS: The goal was to determine the importance of the sodium glucose cotransporter SGLT1 and the glucose uniporter GLUT2 in intestinal glucose absorption during oral glucose tolerance tests (OGTTs) in mice. Glucose absorption was determined in mice using positron emission tomography and three non-metabolizable glucose probes: one specific for SGLTs, one specific for GLUTs, and one a substrate for both SGLTs and GLUTs. Absorption was determined in wild-type, Sglt1-/- , and Glut2-/- mice...
April 29, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29707377/transaxillary-uniportal-video-assisted-thoracoscopic-surgery-for-right-upper-lobectomy
#12
Yaxing Shen, Yong Zhang, Jianchao Sun, Jianying Gu, Yunfeng Yuan, Qun Wang
Uniportal video-assisted thoracic surgery (VATS) was growing popular since its first introduction. Based on the conventional uniportal VATS, we modified the technique and introduced transaxillary uniportal VATS lobectomy in this case report. In March 2017, transaxillary uniportal VATS was firstly attempted on a patient suffering from right upper lobe lesion at the Department of Thoracic Surgery, Zhongshan Hospital, Fudan University. A 4-cm single incision was made at the fossa axillaris paralleled to the skin folds, to which a soft wound protector was applied to reach the third intercostal space along the anterior axillary line...
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29707285/robotic-assisted-thoracic-surgery-versus-uniportal-video-assisted-thoracic-surgery-is-it-a-draw
#13
EDITORIAL
Sara Ricciardi, Carmelina Cristina Zirafa, Federico Davini, Franca Melfi
No abstract text is available yet for this article.
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29701876/arabidopsis-pollen-tube-germination-and-growth-depend-on-the-mitochondrial-calcium-uniporter-complex
#14
Benjamin Selles, Caroline Michaud, Tou-Cheu Xiong, Olivier Leblanc, Mathieu Ingouff
The mitochondrial calcium uniporter complex (MCUc) was recently characterized in details in metazoans and consists of pore-forming units (MCUs) and regulatory factors that channel calcium (Ca2+ ) ion into the mitochondria. MCUs participate in many stress and developmentally related processes involving Ca2+ . Although multiple homologues of MCUs and one regulatory subunit are usually present in plants, the first functional characterization and contribution to Ca2+ related processes of these proteins have been reported recently...
April 27, 2018: New Phytologist
https://www.readbyqxmd.com/read/29701373/uniportal-vats-lobectomy-subxiphoid-approach
#15
Catarina Carvalheiro, Javier Gallego-Poveda, Diego Gonzalez-Rivas, Jorge Cruz
INTRODUCTION: Interest in uniportal video-assisted thoracic surgery (VATS) is rapidly growing worldwide because it represents the surgical approach to the lung with the least possible trauma and in recent years the subxiphoid approach has been used in the field of thoracic surgery as it is associated with lesser pain because there is no intercostal nerve damage and it provides excellent cosmetic outcomes. This technique was recently introduced for major pulmonary resections and even bilateral approaches in selected patients...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701369/uniportal-video-assisted-thorascoscopic-surgery-the-new-paradigm-in-the-surgical-treatment-of-lung-cancer
#16
Pedro Fernandes, Susana Lareiro, Luís Vouga, Miguel Guerra, José Miranda
INTRODUCTION: The progressive development and improvement of minimally invasive approaches in the field of thoracic surgery allowed to establish video-assisted thoracoscopic (VATS) anatomic lung resections as the present technique of choice in the treatment of early stage lung cancer. METHODS: The purpose of this study was to evaluate the surgical outcomes of patients who performed uniportal VATS anatomic lung resections for the treatment of primary lung cancer...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29701368/three-year-experience-on-477-patients-undergoing-uniportal-video-assisted-thoracoscopic-surgery
#17
Susana Lareiro, Pedro Fernandes, Luis Vouga, José Miranda, Miguel Guerra
INTRODUCTION: Uniportal video-assisted thoracic surgery (VATS) technique has been described both for diagnostic and therapeutic indications. Outcomes after uniportal VATS have never been reported in Portuguese large series. We review the safety and efficiency of our initial experience with uniportal VATS. METHODS: In a retrospective study of prospectively collected data, 477 uniportal VATS procedures were analyzed between June 2014 and June 2017. All procedures were performed without rib spreading...
July 2017: Revista Portuguesa de Cirurgia Cardio-torácica e Vascular
https://www.readbyqxmd.com/read/29695246/transcriptomic-analysis-between-self-and-cross-pollinated-pistils-of-tea-plants-camellia-sinensis
#18
Qingping Ma, Changsong Chen, Zhongping Zeng, Zhongwei Zou, Huan Li, Qiongqiong Zhou, Xuan Chen, Kang Sun, Xinghui Li
BACKGROUND: Self-incompatibility (SI) is a major barrier that obstructs the breeding process in most horticultural plants including tea plants (Camellia sinensis). The aim of this study was to elucidate the molecular mechanism of SI in tea plants through a high throughput transcriptome analysis. RESULTS: In this study, the transcriptomes of self- and cross-pollinated pistils of two tea cultivars 'Fudingdabai' and 'Yulv' were compared to elucidate the SI mechanism of tea plants...
April 25, 2018: BMC Genomics
https://www.readbyqxmd.com/read/29690894/uniportal-video-assisted-thoracoscopic-surgery-following-neoadjuvant-chemotherapy-for-locally-advanced-lung-cancer
#19
Zhiqiang Yang, Chunbo Zhai
BACKGROUND: Several retrospective studies have confirmed that video-assisted thoracoscopic surgery (VATS) following neoadjuvant chemotherapy is a safe and feasible treatment for advanced non-small cell lung cancer patients. As a minimally invasive technique, VATS usually leads to better clinical outcomes and better compliance with adjuvant treatment than conventional thoracotomy. Uniportal VATS (U-VATS) as an alternative option to conventional multi-port VATS has attracted much attention recently because reduced number and size of incisions may help to decrease inflammatory response and reduce postoperative pain for patients...
April 24, 2018: Journal of Cardiothoracic Surgery
https://www.readbyqxmd.com/read/29686046/mcu-interacts-with-miro1-to-modulate-mitochondrial-functions-in-neurons
#20
Robert F Niescier, Kido Hong, Dongkeun Park, Kyung-Tai Min
Mitochondrial Ca2+ uptake is gated by the mitochondrial calcium uniplex, which is comprised of MCU, the Ca2+ pore-forming subunit of the complex, and its regulators. Ca2+ influx through MCU affects both mitochondrial function and movement in neurons, but its direct role in mitochondrial movement has not been explored. In this report, we show a link between MCU and Miro1, a membrane protein known to regulate mitochondrial movement. We find that MCU interacts with Miro1 through MCU's N-terminal domain, previously thought to be the mitochondrial targeting sequence...
April 23, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
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