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https://www.readbyqxmd.com/read/28631404/structural-connectivity-differences-in-motor-network-between-tremor-dominant-and-nontremor-parkinson-s-disease
#1
Gaetano Barbagallo, Maria Eugenia Caligiuri, Gennarina Arabia, Andrea Cherubini, Angela Lupo, Rita Nisticò, Maria Salsone, Fabiana Novellino, Maurizio Morelli, Giuseppe Lucio Cascini, Domenico Galea, Aldo Quattrone
Motor phenotypes of Parkinson's disease (PD) are recognized to have different prognosis and therapeutic response, but the neural basis for this clinical heterogeneity remains largely unknown. The main aim of this study was to compare differences in structural connectivity metrics of the main motor network between tremor-dominant and nontremor PD phenotypes (TD-PD and NT-PD, respectively) using probabilistic tractography-based network analysis. A total of 63 PD patients (35 TD-PD patients and 28 NT-PD patients) and 30 healthy controls underwent a 3 T MRI...
June 20, 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28629676/percutaneous-nephrolithotomy-puncture-and-tract-dilation-evidence-on-the-safety-of-approaches-to-the-infundibulum-of-the-middle-renal-calyx
#2
Panagiotis Kallidonis, Christina Kalogeropoulou, Iason Kyriazis, Dimitrios Apostolopoulos, Panagiotis Kitrou, Dimitrios Kotsiris, Panteleimon Ntasiotis, Evangelos Liatsikos
OBJECTIVES: To investigate the anatomical relations of the papillary, infundibular and pelvic approach to percutaneous nephrolithotomy (PCNL) and evaluate the amount of vascularization at the respective sites. MATERIALS: (99m)Tc-dimercaptosuccinic acid SPECT/CT renal scintigraphies or Computerized tomographies perfusion (CTP) were performed in 40 patients (prone n=20 or supine position n=20). The angle of approach (AoA) for access tracts the respective regions of interest (ROIs) to the mid-calyceal papilla and infundibulum as well as renal pelvis were designed and compared...
June 16, 2017: Urology
https://www.readbyqxmd.com/read/28623512/phosphatidylethanolamine-targeting-for-cell-death-imaging-in-early-treatment-response-evaluation-and-disease-diagnosis
#3
REVIEW
Filipe Elvas, Sigrid Stroobants, Leonie Wyffels
Phosphatidylethanolamine (PE) is one of the most abundant phospholipids in mammalian plasma membranes. In healthy cells, PE resides predominantly in the inner leaflet of the cell membrane. In dead or dying cells on the other hand, PE is externalized to the outer leaflet of the plasma membrane. The exposure of PE on the cell surface has therefore become an attractive target for the molecular imaging of cell death using single-photon emission computed tomography (SPECT) and positron emission tomography (PET)...
June 16, 2017: Apoptosis: An International Journal on Programmed Cell Death
https://www.readbyqxmd.com/read/28623409/evaluation-of-bone-viability-in-patients-after-girdlestone-arthroplasty-comparison-of-bone-spect-ct-and-mri
#4
G Diederichs, P Hoppe, F Collettini, G Wassilew, B Hamm, W Brenner, M R Makowski
PURPOSE: To test the diagnostic performance of bone SPECT/CT and MRI for the evaluation of bone viability in patients after girdlestone-arthroplasty with histopathology used as gold standard. MATERIALS AND METHODS: In this cross-sectional study, patients after girdlestone-arthroplasty were imaged with single-photon-emission-computed-tomography/computed-tomography (SPECT/CT) bone-scans using 99mTc-DPD. Additionally, 1.5 T MRI was performed with turbo-inversion-recovery-magnitude (TIRM), contrast-enhanced T1-fat sat (FS) and T1-mapping...
June 16, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28622946/estimation-of-myocardial-flow-reserve-utilizing-an-ultrafast-cardiac-spect-comparison-with-coronary-angiography-fractional-flow-reserve-and-the-syntax-score
#5
Masao Miyagawa, Yoshiko Nishiyama, Teruyoshi Uetani, Akiyoshi Ogimoto, Shuntaro Ikeda, Hayato Ishimura, Emiri Watanabe, Rami Tashiro, Yuki Tanabe, Teruhito Kido, Akira Kurata, Teruhito Mochizuki
BACKGROUND: Quantitative assessment of myocardial flow reserve (MFR) by single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) is challenging but may facilitate evaluation of multi-vessel coronary artery disease (CAD). METHODS: We enrolled 153 patients with suspected or known CAD, referred for pharmacological stress MPI. They underwent a (99m)Tc-perfusion stress/rest SPECT with an ultrafast cadmium-zinc-telluride (CZT) camera. Dynamic data were acquired and time-activity curves fitted to a 1-tissue compartment analysis with input function...
June 13, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28622166/quantitative-analysis-of-iodine-image-of-dual-energy-computed-tomography-at-rest-comparison-with-99mtc-tetrofosmin-stress-rest-single-photon-emission-computed-tomography-myocardial-perfusion-imaging-as-the-reference-standard
#6
Takehiro Nakahara, Takuji Toyama, Masahiro Jinzaki, Ryotaro Seki, Yuichiro Saito, Tetsuya Higuchi, Minoru Yamada, Masashi Arai, Yoshito Tsushima, Sachio Kuribayashi, Masahiko Kurabayashi
PURPOSE: Dual-energy computed tomography (DECT) can be used for visual determination of iodine distribution in the myocardium (iodine image); however, the accuracy and reproducibility of the process remains debatable. Because of the low contrast-to-noise ratio of CT, we hypothesized that quantitative measurement may be more accurate for detecting myocardial ischemia. In this study, we evaluated our quantitative method by comparing it with visual analysis using Tc-tetrofosmin (TF) stress-rest single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI) as the reference standard...
June 15, 2017: Journal of Thoracic Imaging
https://www.readbyqxmd.com/read/28621621/indications-technique-and-safety-profile-of-insular-stereoelectroencephalography-electrode-implantation-in-medically-intractable-epilepsy
#7
Soha Alomar, Jeffrey P Mullin, Saksith Smithason, Jorge Gonzalez-Martinez
OBJECTIVE Insular epilepsy is relatively rare; however, exploring the insular cortex when preoperative workup raises the suspicion of insular epilepsy is of paramount importance for accurate localization of the epileptogenic zone and achievement of seizure freedom. The authors review their clinical experience with stereoelectroencephalography (SEEG) electrode implantation in patients with medically intractable epilepsy and suspected insular involvement. METHODS A total of 198 consecutive cases in which patients underwent SEEG implantation with a total of 1556 electrodes between June 2009 and April 2013 were reviewed...
June 16, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28619419/usefulness-of-scintigraphy-with-labelled-leucocytes-and-spect-ct-in-vascular-graft-infection
#8
V Marín-Oyaga, C Gutierrez-Villamil, D García-Concha, S Arevalo-Leal
Vascular graft infections are a rare complication in this type of procedure. However, when they do occur, they usually have high morbidity, and even a high mortality. Proper identification and location is crucial for the appropriate and early management, whether medical or surgical, thus knowledge of the right tools is paramount. Nuclear medicine studies play an important role in this regard, either by using labelled white blood cells scintigraphy or (18)F-FDG. The choice, among other factors, will depend on the experience with both techniques by the different groups, their knowledge of them, as well as their availability...
June 12, 2017: Revista Española de Medicina Nuclear e Imagen Molecular
https://www.readbyqxmd.com/read/28615707/-99m-tc-labeled-bevacizumab-for-detecting-atherosclerotic-plaque-linked-to-plaque-neovascularization-and-monitoring-antiangiogenic-effects-of-atorvastatin-treatment-in-apoe-mice
#9
Hui Tan, Jun Zhou, Xiangdong Yang, Mieradilijiang Abudupataer, Xiao Li, Yan Hu, Jie Xiao, Hongcheng Shi, Dengfeng Cheng
Atherosclerotic neovascularization plays a significant role in plaque instability as it provides additional lipids and inflammatory mediators to lesions, and resulting in intraplaque hemorrhage. Vascular endothelial growth factor-A (VEGF-A) is considered the predominant proangiogenic factor in angiogenesis. Bevacizumab, a humanized monoclonal antibody, specifically binds to all VEGF-A isoforms with high affinity. Therefore, in this study, we designed (99m)Tc-MAG3-bevacizumab as a probe, and then investigated its usefulness as a new imaging agent for the detection of plaque neovessels, while also assessing the therapeutic effect of atorvastatin treatment...
June 14, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28614134/value-of-99mtc-mibi-spect-ct-parathyroid-imaging-and-ultrasonography-for-concomitant-thyroid-carcinoma
#10
Rui Guo, Jiqiu Wang, Min Zhang, Miao Zhang, Hongping Meng, Yifan Zhang, Biao Li
PURPOSE: We aimed to assess the frequency of carcinoma in cases with suspected parathyroid adenoma and test the value of Tc-methoxyisobutylisonitrile (Tc-MIBI) single-photon emission computed tomography/computed tomography (SPECT/CT) parathyroid imaging and neck ultrasonography in detecting concomitant thyroid carcinoma. PATIENTS AND METHODS: We enrolled 741 patients with clinically suspected parathyroid adenoma who underwent Tc-MIBI planer scans and SPECT/CT of the skull base, neck, and thorax; patients also underwent ultrasonography within 1 month before SPECT/CT...
June 13, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28613198/lu-177-psma-617-prostate-specific-membrane-antigen-inhibitor-therapy-in-patients-with-castration-resistant-prostate-cancer-stability-bio-distribution-and-dosimetry
#11
Levent Kabasakal, Türkay Toklu, Nami Yeyin, Emre Demirci, Mohammad Abuqbeitah, Meltem Ocak, Aslan Aygün, Emre Karayel, Hüseyin Pehlivanoğlu, Nalan Alan Selçuk
OBJECTIVE: The aim of the study was to estimate the radiation-absorbed doses and to study the in vivo and in vitro stability as well as pharmacokinetic characteristics of lutetium-177 (Lu-177) prostate-specific membrane antigen (PSMA)-617. METHODS: For this purpose, 7 patients who underwent Lu-177-PSMA therapy were included into the study. The injected Lu-177-PSMA-617 activity ranged from 3.6 to 7.4 GBq with a mean of 5.2±1.8 GBq. The stability of radiotracer in saline was calculated up to 48 h...
June 1, 2017: Molecular Imaging and Radionuclide Therapy
https://www.readbyqxmd.com/read/28611426/radioiodination-of-bodipy-and-its-application-to-a-nuclear-and-optical-dual-functional-labeling-agent-for-proteins-and-peptides
#12
Masahiro Ono, Hiroyuki Watanabe, Yuki Ikehata, Ning Ding, Masashi Yoshimura, Kohei Sano, Hideo Saji
In molecular imaging research, the development of multimodal imaging probes has recently attracted much attention. In the present study, we prepared radioiodinated BODIPY and applied it as a nuclear and optical dual functional labeling agent for proteins and peptides. We designed and synthesized [(125)I]BODIPY with a N-hydroxysuccinimide (NHS) ester, and evaluated its utility as a nuclear and fluorescent dual labeling agent for proteins and peptides. In the radioiodination reaction of BODIPY-NHS with [(125)I]NaI, [(125)I]BODIPY-NHS was obtained at a 48% radiochemical yield...
June 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28611245/optimization-of-spect-measurement-of-myocardial-blood-flow-with-corrections-for-attenuation-motion-and-blood-binding-compared-to-pet
#13
R Glenn Wells, Brian Marvin, Marlie Poirier, Jennifer M Renaud, Robert A deKemp, Terrence D Ruddy
Myocardial blood flow (MBF) and flow reserve (MFR) measured with positron emission tomography (PET) have clinical value. Single-photon emission computed tomography (SPECT) cameras with solid-state detectors can obtain dynamic images for measurement of MBF and MFR. In this study, SPECT measurements of MBF made using (99m)Tc-tetrofosmin were compared to PET in the same patients. Methods: Thirty-one patients had PET MBF rest-stress studies performed with (82)Rb or (13)N- ammonia within one month of their SPECT...
June 13, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28611231/validation-of-the-left-ventricular-ejection-fraction-with-iq-spect-system-in-small-heart-patients
#14
Hiroto Yoneyama, Takayuki Shibutani, Takahiro Konishi, Asuka Mizutani, Hashimoto Ryosuke, Masahisa Onoguchi, Koichi Okuda, Shinro Matsuo, Kenichi Nakajima, Kinuya Seigo
The IQ-SPECT system equipped with a multifocal (SMARTZOOM) collimator using an ordered subset conjugate gradient minimization (OSCGM) algorithm reduces the acquisition time of myocardial perfusion imaging (MPI) compared to conventional gamma cameras equipped with low-energy high-resolution (LEHR) collimators. We compared IQ-SPECT with a conventional single-photon emission computed tomography (SPECT) system for estimating the left ventricular ejection fraction (LVEF) in small-heart patients. Methods: The study group consisted of 98 consecutive patients who underwent a 1-day stress-rest MPI study with a (99m)Tc-labeled agent for preoperative risk assessment...
June 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28605001/determination-of-structural-femoral-head-allograft-viability-and-integrity-with-a-novel-diagnostic-tool-spect-ct-a-preliminary-study
#15
Kasım Kilicarslan, Nadir Yalcin, Vedat Bicici, Elif Ozdemir, Izzet Bingol, Seyda Turkolmez
OBJECTIVE: To evaluate the viability and integrity of fresh frozen bulk femoral head allografts obtained from the institutional bone bank that were used to reconstruct severe acetabular defects and to validate the SPECT/CT method which gives both anatomical and functional data for this purpose. METHODS: We retrospectively reviewed 9 patients (6 female, 3 male; mean age 63.6 years). Preoperative and postoperative leg lengths, existence of the Trendelenburg sign, range of motion of the hip, visual analogue score (VAS), Harris Hip Score (HHS) and any complication were assesed at each follow-up...
June 2, 2017: Hip International: the Journal of Clinical and Experimental Research on Hip Pathology and Therapy
https://www.readbyqxmd.com/read/28604617/targeted-magnetic-nanotheranostics-of-cancer
#16
REVIEW
Irina Belyanina, Olga Kolovskaya, Sergey Zamay, Ana Gargaun, Tatiana Zamay, Anna Kichkailo
Current advances in targeted magnetic nanotheranostics are summarized in this review. Unique structural, optical, electronic and thermal properties of magnetic materials in nanometer scale are attractive in the field of biomedicine. Magnetic nanoparticles functionalized with therapeutic molecules, ligands for targeted delivery, fluorescent and other chemical agents can be used for cancer diagnostic and therapeutic purposes. High selectivity, small size, and low immunogenicity of synthetic nucleic acid aptamers make them attractive delivery agents for therapeutic purposes...
June 12, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28603413/identifying-the-heterogeneity-of-copd-by-v-p-spect-a-new-tool-for-improving-the-diagnosis-of-parenchymal-defects-and-grading-the-severity-of-small-airways-disease
#17
M Bajc, Y Chen, J Wang, X Y Li, W M Shen, C Z Wang, H Huang, A Lindqvist, X Y He
INTRODUCTION: Airway obstruction and possible concomitant pulmonary diseases in COPD cannot be identified conventionally with any single diagnostic tool. We aimed to diagnose and grade COPD severity and identify pulmonary comorbidities associated with COPD with ventilation/perfusion single-photon emission computed tomography (V/P SPECT) using Technegas as the functional ventilation imaging agent. METHODS: 94 COPD patients (aged 43-86 years, Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages I-IV) were examined with V/P SPECT and spirometry...
2017: International Journal of Chronic Obstructive Pulmonary Disease
https://www.readbyqxmd.com/read/28600950/histamine-promotes-the-differentiation-of-macrophages-from-cd11b-myeloid-cells-and-formation-of-foam-cells-through-a-stat6-dependent-pathway
#18
Lili Xu, Dengfeng Cheng, Zheyong Huang, Suling Ding, Weiwei Zhang, Hui Tan, Hongcheng Shi, Ruizhen Chen, Yunzeng Zou, Timothy C Wang, Xiangdong Yang, Junbo Ge
BACKGROUND AND AIMS: The enzyme histidine decarboxylase (Hdc), which generates histamine, is highly expressed in CD11b(+)Gr-1(+) myeloid cells that play a critical role in infection, inflammation and tumorigenesis. The aim of this study was to explore the role of Hdc-expressing CD11b(+) myeloid cells or histamine in atherogenesis. METHODS: Hdc-EGFP bacterial artificial chromosome (BAC) transgenic reporter mice (Hdc-EGFP) were used to track Hdc expression during the development of atherosclerosis...
May 23, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/28600750/intra-operative-hemorrhage-due-to-hyperperfusion-during-direct-revascularization-surgery-in-an-adult-patient-with-moyamoya-disease-a-case-report
#19
Hiroki Uchida, Hidenori Endo, Miki Fujimura, Toshiki Endo, Kuniyasu Niizuma, Teiji Tominaga
Hemorrhagic complication is one of the notable surgical complications of the revascularization surgery for moyamoya disease (MMD). Cerebral hyperperfusion (CHP) has been considered as the underlying cause of this complication. It mostly occurs several days after surgery, but the intra-operative hemorrhage immediately after bypass has not been reported previously. A 21-year-old woman presented right thalamic hemorrhage and was diagnosed as having MMD by cerebral angiography. In light of the location of the hemorrhage at the vascular territory of posterior circulation and the manifestation of transient ischemic attack during the follow-up period, she underwent revascularization surgery to prevent future ischemic attack and rebleeding...
June 9, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28596948/standardization-of-123-i-meta-iodobenzylguanidine-myocardial-sympathetic-activity-imaging-phantom-calibration-and-clinical-applications
#20
REVIEW
Kenichi Nakajima, Derk O Verschure, Koichi Okuda, Hein J Verberne
PURPOSE: Myocardial sympathetic imaging with (123)I-meta-iodobenzylguanidine ((123)I-mIBG) has gained clinical momentum. Although the need for standardization of (123)I-mIBG myocardial uptake has been recognized, the availability of practical clinical standardization approaches is limited. The need for standardization includes the heart-to-mediastinum ratio (HMR) and washout rate with planar imaging, and myocardial defect scoring with single-photon emission computed tomography (SPECT)...
2017: Clinical and Translational Imaging: Reviews in Nuclear Medicine and Molecular Imaging
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