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Ching-Tzu Yen, Meng-Ni Fan, Yung-Li Yang, Sheng-Chieh Chou, I-Shing Yu, Shu-Wha Lin
Hemophilia is the most well-known hereditary bleeding disorder, with an incidence of one in every 5000 to 30,000 males worldwide. The disease is treated by infusion of protein products on demand and as prophylaxis. Although these therapies have been very successful, some challenging and unresolved tasks remain, such as reducing bleeding rates, presence of target joints and/or established joint damage, eliminating the development of inhibitors, and increasing the success rate of immune-tolerance induction (ITI)...
2016: Thrombosis Journal
Julie A Gervais, James K Roush, David S Biller
OBJECTIVES: To assess the potential of a new single-session surgical procedure, the overlapping pubic and ischiatic osteotomy (OPIO) for modification of bilateral hip conformation. We hypothesized that OPIO would be simple to perform with currently available surgical equipment, through a single surgical approach, with minimal potential morbidity, and that it would allow adequate simultaneous bilateral improvement of coxofemoral joint conformation in patients at risk of canine hip dysplasia...
October 20, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Felix M Duerr, Alexandra Pauls, Chris Kawcak, Kevin Haussler, Gina Bertocci, Valerie Moorman, Melissa King
OBJECTIVE: To evaluate the use of inertial measurement units (IMU) for quantification of canine limb kinematics. METHODS: Sixteen clinically healthy, medium-sized dogs were enrolled. Baseline kinematic data were acquired using an optical motion capture system. Following this baseline data acquisition, a harness system was used for attachment of IMU to the animals. Optical kinematic data of dogs with and without the harness were compared to evaluate the influence of the harness on gait parameters...
October 20, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
A Przeworski, Z Adamiak, J Głodek
The most common cause of hindlimb lameness in dogs is cranial cruciate ligament rupture. In 48-77.3% of the population this trauma leads to secondary damage of the meniscus. Depending on the magnetic strength of the used device, different diagnostic accuracy can be achieved. The examination sensitivity of magnetic resonance imaging is affected by many factors which are independent of diagnostic strength, such as correct positioning of the patient, size of the stifle joint examined, or selection of the right protocol of sequences...
September 1, 2016: Polish Journal of Veterinary Sciences
A Coetzer, A H Kidane, M Bekele, A D Hundera, E G Pieracci, M L Shiferaw, R Wallace, L H Nel
The Stepwise Approach towards Rabies Elimination (SARE) tool was developed through a joint effort of the Food and Agriculture Organization (FAO) of the United Nations and the Global Alliance for Rabies Control (GARC), to provide a standard mechanism for countries to assess their rabies situation and measure progress in eliminating the disease. Because the African continent has the highest per capita death rate from rabies, and Ethiopia is estimated to have the second largest number of rabies deaths of all African countries, Ethiopia undertook a self-assessment by means of the Stepwise Approach towards Rabies Elimination (SARE) tool...
October 14, 2016: Antiviral Research
Katherine C Leonard, Michael P Kowaleski, William B Saunders, Robert J McCarthy, Randy J Boudrieau
OBJECTIVES: To describe the surgical technique and report short-term outcome for combined tibial plateau levelling osteotomy and tibial tuberosity transposition (TPLO-TTT) as an option in the treatment of cranial cruciate ligament insufficiency with concomitant medial patellar luxation. METHODS: Medical records were reviewed (2011-2013) of dogs that underwent a standard tibial plateau levelling osteotomy followed by a tibial tuberosity transposition in the frontal plane and stabilized with pin and tension-band wire fixation as a component of surgical treatment for combined cranial cruciate ligament insufficiency and medial patellar luxation...
October 14, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Rebecca N Howie, Timothy L Foutz, Curtis C Cathcart, Jeff S Burmeister, Steve C Budsberg
OBJECTIVE: To investigate the relationship between tibiofemoral kinematics before and after total knee replacement (TKR) in vitro. ANIMALS: Eight canine hemipelves. METHODS: A modified Oxford Knee Rig was used to place cadaveric limbs through a range of passive motion allowing the kinematics of the stifle to be evaluated. Four measurements were performed: a control stage, followed by a cranial cruciate transection stage, then following TKR with the musculature intact stage, and finally TKR with removal of limb musculature stage...
October 14, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
Susanne M Kaiser, Oliver Harms, Martin Konar, Anne Staudacher, Anna Langer, Cetina Thiel, Martin Kramer, Sebastian Schaub, Kerstin H von Pückler
OBJECTIVES: To describe clinical, radiographic, and magnetic resonance imaging (MRI) findings in 16 dogs diagnosed with gastrocnemius musculotendinopathy. METHODS: Retrospective evaluation of medical records, radiographs, and MRI results, as well as follow-up completed by telephone questionnaire. RESULTS: Most dogs had chronic hindlimb lameness with no history of trauma or athletic activities. Clinical examination revealed signs of pain on palpation without stifle joint instability...
October 14, 2016: Veterinary and Comparative Orthopaedics and Traumatology: V.C.O.T
K Rajkumar, A Bhattacharya, S David, S Hari Balaji, R Hariharan, M Jayakumar, N Balaji
AIM: This study was conducted to assess the extent of knowledge, awareness, attitude, and risks of zoonotic diseases among livestock owners in Puducherry region. MATERIALS AND METHODS: A total of 250 livestock farmers were selected randomly from eight revenue villages. And each farmer was interviewed with a questionnaire containing both open- and close-ended questions on various aspects of zoonotic diseases, a total of 49 questionnaires were framed to assess the source and transmission of infection to the farmers and to test their knowledge and awareness about zoonotic diseases...
September 2016: Veterinary World
Masaaki Katayama
OBJECTIVE: To report appositional augmentation of Achilles tendon rupture in a toy breed dog with an intact flexor digitorum lateralis (FDL) muscle tendon. STUDY DESIGN: Clinical case report. ANIMALS: Two-year-old spayed female Toy Poodle with Achilles tendon rupture. METHODS: The Achilles tendon was accidentally ruptured by hair clippers during grooming. The dog demonstrated a plantigrade stance without digital flexion of the right hind limb...
October 6, 2016: Veterinary Surgery: VS
Eva Coppieters, Bernadette Van Ryssen, Henri van Bree, Geert Verhoeven, Bart Broeckx, Evelien de Bakker, Dieter Deforce, Ingrid Gielen
Medial compartment erosion is an advanced stage of medial coronoid disease, an important cause of elbow lameness in dogs, with treatment and the expected prognosis depending on the extent of the cartilage lesions. The identification of specific computed tomographic (CT) findings might facilitate the nonsurgical diagnosis and add to treatment decision making. Aims of this retrospective, analytical, method comparison study were to describe CT findings in elbows of dogs arthroscopically diagnosed with medial compartment erosion and to compare CT vs...
October 4, 2016: Veterinary Radiology & Ultrasound
Robert Harman, Kim Carlson, Jamie Gaynor, Scott Gustafson, Sarit Dhupa, Keith Clement, Michael Hoelzler, Tim McCarthy, Pamela Schwartz, Cheryl Adams
Osteoarthritis (OA) is a degenerative joint disease with a high prevalence in dogs. Mesenchymal stem cells (MSCs) have been used to treat humans, dogs, and horses with OA. This report describes a prospective, randomized, blinded, and placebo-controlled clinical efficacy study of intraarticular allogeneic adipose stem cells for the treatment of dogs with OA. Health assessments and measurements of pain and activity impairment were performed at baseline and at selected time points through day 60. The primary outcome variable was the owner Client-Specific Outcome Measurement (CSOM) and secondary measures included veterinary pain on manipulation, veterinary global score, and owner global score...
2016: Frontiers in Veterinary Science
Deborah A Grosenbaugh, Daniel R Rissi, Paula M Krimer
Lyme disease in dogs can be effectively prevented by vaccination against antigens expressed by the spirochete Borrelia burgdorferi during transmission by the tick vector Ixodes sp. Lyme vaccine efficacy has traditionally been based on indicators of infection following wild-caught tick challenge whereas most other types of vaccine are required to demonstrate protection from clinical signs of disease. In this vaccination-challenge study we sought to demonstrate the ability of a nonadjuvanted, outer surface protein A (OspA) vaccine to protect from infection and to prevent synovial lesions consistent with Borreliosis...
November 1, 2016: Veterinary Immunology and Immunopathology
A Villamonte-Chevalier, W Dingemanse, B J G Broeckx, A Van Caelenberg, A Agut, L Duchateau, H van Bree, I Gielen
The aims of this study were: (1) to determine the inter-observer repeatability of particular regions of the canine elbow joints; (2) to assess the effect of age, bodyweight and breed on bone density in healthy young dogs; (3) to compare Hounsfield units (HU) and bone density (BD) measurements between normal elbow joints and diseased elbow joints; and (4) to determine the sensitivity and specificity for HU and BD measurements in specific regions in the canine elbow joint. Regions with the highest repeatability were located at the medial coronoid process (MCP) base and apex, and at the level of the humerus, on the sagittal and sagittal oblique planes of the elbow joint...
October 2016: Veterinary Journal
Annalisa P Liotta, Maud Girod, Dominique Peeters, Charlotte Sandersen, Thierry Couvreur, Géraldine Bolen
OBJECTIVE To determine clinical effects of CT-guided lumbosacral facet joint, transforaminal epidural, and translaminar epidural injections of methylprednisolone acetate in healthy dogs. ANIMALS 15 healthy Beagles. PROCEDURES Dogs were randomly assigned to 3 groups (5 dogs/group) and received a single CT-guided lumbosacral facet joint, transforaminal epidural, or translaminar epidural injection of methylprednisolone acetate (0.1 mg/kg). Contrast medium was injected prior to injection of methylprednisolone to verify needle placement...
October 2016: American Journal of Veterinary Research
Christopher V Nagelli, James L Cook, Kei Kuroki, Chantelle Bozynski, Richard Ma, Timothy E Hewett
Complications following anterior cruciate ligament (ACL) injury and reconstruction that include chronic dysfunction, second ACL injury, and posttraumatic osteoarthritis (OA) may be interrelated and stem from the inability to fully restore native ACL integrity and function. The loss of ACL sensory input following injury may significantly contribute to joint dysfunction. We developed a novel preclinical animal model to assess the contributions of ACL sensory afferents to knee joint function and health. We hypothesized that ACL sensory denervation would manifest in knee joint dysfunction and development of early OA...
September 20, 2016: Journal of Knee Surgery
Maria McInerney, Ilona Csizmadi, Christine M Friedenreich, Francisco Alaniz Uribe, Alberto Nettel-Aguirre, Lindsay McLaren, Melissa Potestio, Beverly Sandalack, Gavin R McCormack
BACKGROUND: The neighbourhood environment may play an important role in diet quality. Most previous research has examined the associations between neighbourhood food environment and diet quality, and neighbourhood socioeconomic status and diet quality separately. This study investigated the independent and joint effects of neighbourhood food environment and neighbourhood socioeconomic status in relation to diet quality in Canadian adults. METHODS: We undertook a cross-sectional study with n = 446 adults in Calgary, Alberta (Canada)...
2016: BMC Public Health
Melissa K Miller, Ju Jiang, Melissa Truong, Tamasin Yarina, Holly Evans, Timothy P Christensen, Allen L Richards
Four species of ticks known to parasitize humans (Amblyomma americanum (lone star tick), Dermacentor variabilis (American dog tick), Amblyomma maculatum (Gulf Coast tick), and Ixodes scapularis (black-legged tick)) were collected at Joint Base Langley-Eustis, Fort Eustis, Virginia during 2009. These ticks were tested individually (adults and nymphs) and in pools of 15 (larvae) for pathogens of public health importance within the genera: Rickettsia, Borrelia, and Ehrlichia, by quantitative real-time polymerase chain reaction (qPCR) assays and, where appropriate, multilocus sequence typing (MLST)...
October 2016: U.S. Army Medical Department Journal
Fumitaka Takahashi, Takaharu Hakozaki, Nobuo Kanno, Yasuji Harada, Shinya Yamaguchi, Yasushi Hara
We evaluated comparatively the mechanical strength in three kinds of surgical fixation techniques for canine atlantoaxial joint. Atlantoaxial plate fixation (APF), polymethylmethacrylate (PMMA) fixation (PMF) and transarticular fixation (TAF) were applied to the atlas and axis harvested from healthy beagle dogs, and then the specimens were tested. The PMF group had significantly higher resistance to flexion than the APF group (P=0.030) and the TAF group (P=0.004). There were no significant differences in resistance to torsion between the APF group and the PMF group, while the APF group had significantly higher resistance to torsion than the TAF group (P=0...
September 4, 2016: Journal of Veterinary Medical Science
H Dirrig, R Drees, R Lam
OBJECTIVES: To evaluate the use of dual-phase contrast-enhanced computed tomography for the depiction of the features of the male genital tract, highlighting differences between entire and neutered dogs. METHODS: Computed tomography exams of 23 entire and 23 neutered male dogs with no history of urogenital disease were included in this retrospective study, with exams acquired pre-, 30 and 98·9 ±27·4 seconds after intravenous contrast administration. The genital structures were subjectively evaluated for visibility, contrast enhancement and enhancement pattern and differences between entire and neutered dogs were described...
September 3, 2016: Journal of Small Animal Practice
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