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https://www.readbyqxmd.com/read/27664450/correlations-between-peripheral-parasite-load-and-common-clinical-and-laboratory-alterations-in-dogs-with-visceral-leishmaniasis
#1
R B P Torrecilha, Y T Utsunomiya, A M Bosco, B F Almeida, P P Pereira, L G Narciso, D C M Pereira, L Baptistiolli, L Calvo-Bado, O Courtenay, C M Nunes, P C Ciarlini
Intensity of peripheral parasite infection has an important role in the transmission of Leishmania spp. from one host to another. As parasite load quantification is still an expensive procedure to be used routinely in epidemiological surveillance, the use of surrogate predictors may be an important asset in the identification of dogs with high transmitting ability. The present study examined whether common clinical and laboratory alterations can serve as predictors of peripheral parasitism in dogs naturally infected with Leishmania spp...
September 15, 2016: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/27529988/from-single-nucleotide-substitutions-up-to-chromosomal-deletions-genetic-pause-of-leucism-associated-disorders-in-animals
#2
REVIEW
Katharina Fleck, Georg Erhardt, Gesine Lühken
Leucism is characterized by a complete or partial white skin and hair in combination with pigmented irides, which can be vivid blue or heterochromatic. This is due to a complete or partial lack of melanocytes. The underlying pathogenesis is a disturbed emigration or differentiation of neural crest-derived cells. Therefore, leucistic phenotypes can be associated with defects, which mainly impair sensory organs and nerves. In humans, a well-known example is the Waardenburg syndrome. Leucism-associated disorders were also described in mouse, rat, hamster, rabbit, mink, cat, dog, pig, sheep, llama, alpaca, cattle and horse...
July 2016: Berliner und Münchener Tierärztliche Wochenschrift
https://www.readbyqxmd.com/read/27427177/the-usefulness-of-dermoscopy-in-canine-pattern-alopecia-a-descriptive-study
#3
Giordana Zanna, Paola Roccabianca, Eric Zini, Sara Legnani, Fabia Scarampella, Silvana Arrighi, Antonella Tosti
BACKGROUND: Dermoscopic studies evaluating noninflammatory, nonpruritic progressive alopecia attributable to pattern alopecia are currently unavailable. HYPOTHESIS/OBJECTIVES: To evaluate the dermoscopic features observed in healthy skin of short coated dogs and compare these findings with those observed in dogs affected by pattern alopecia diagnosed by clinical and dermatopathological examination. ANIMALS: Thirty male and female, healthy, breed matched, young adult, short coated dogs (controls) and 30 male and female, young adult, short coated dogs affected by pattern alopecia...
July 18, 2016: Veterinary Dermatology
https://www.readbyqxmd.com/read/27354641/immunopotentiator-from-pantoea-agglomerans-1-ip-pa1-promotes-murine-hair-growth-and-human-dermal-papilla-cell-gene-expression
#4
Koji Wakame, Hiroshi Okawa, Ken-Ich Komatsu, Akifumi Nakata, Keisuke Sato, Hiroyuki Ingawa, Chie Kohchi, Takashi Nishizawa, Gen-Ichiro Soma
BACKGROUND/AIM: The lipopolysaccharide (LPS)-like compound derived from Pantoea agglomerans (immunopotentiator from Pantoea agglomerans 1 (IP-PA1)) has been used not only as dietary supplement or cosmetic for humans, but also by Japanese veterinarians as an anti-tumor, anti-allergy, "keep a fine coat of fur" and hair growth-promoting functional food for dogs and cats. In the present study, we focused on the hair growth-promoting effects of IP-PA1 on a hair-shaved animal model and its mechanism of action...
July 2016: Anticancer Research
https://www.readbyqxmd.com/read/27341526/anatomical-mapping-and-density-of-merkel-cells-in-skin-and-mucosae-of-the-dog
#5
Gustavo A Ramírez, Francisco Rodríguez, Óscar Quesada, Pedro Herráez, Antonio Fernández, Antonio Espinosa-de-Los-Monteros
Merkel cells (MCs) are specialized cutaneous receptor cells involved with tactile sense. Although the distribution of MCs has been extensively studied in humans and rodents, their precise distribution and density throughout skin in the dog has not previously been determined. Knowledge of their distribution could facilitate understanding of their functions. By using of immunohistochemistry, density, and anatomical mapping of the MCs population in the dog skin was determined. Assessment of the MCs innervation was also achieved...
September 2016: Anatomical Record: Advances in Integrative Anatomy and Evolutionary Biology
https://www.readbyqxmd.com/read/26933270/dorsal-skin-necrosis-secondary-to-a-solar-induced-thermal-burn-in-a-brown-coated-dachshund
#6
Julia P Sumner, Cherie M Pucheu-Haston, Natalie Fowlkes, Sandra Merchant
A 5-year-old neutered male brown dachshund dog was presented for a large dorsal cutaneous burn that occurred following direct sunlight exposure outdoors in high ambient temperatures. Although burns are quite common in dogs, full-thickness solar-induced radiation burns are less common and have not been previously reported in animals without a black hair coat.
March 2016: Canadian Veterinary Journal. la Revue Vétérinaire Canadienne
https://www.readbyqxmd.com/read/26897627/validating-and-reliability-testing-the-descriptive-data-and-three-different-disease-diagnoses-of-the-internet-based-dogrisk-questionnaire
#7
Johanna Roine, Liisa Uusitalo, Anna Hielm-Björkman
BACKGROUND: The DOGRISK questionnaire is an internet-based ongoing study of canine nutrition, living environment, and disease. Here we aim to assess the performance of the questionnaire using data from the first three years in relation to some descriptive and disease variables. We used associated questions, official register records, test-retest repeatability, and email/mail contact with questionnaire respondents. RESULTS: Reliability against an official register of gender, season of birth, breed, and results of hip radiography was tested and Cohen's Kappa was between 0...
2016: BMC Veterinary Research
https://www.readbyqxmd.com/read/26582259/reverse-genetic-screen-for-loss-of-function-mutations-uncovers-a-frameshifting-deletion-in-the-melanophilin-gene-accountable-for-a-distinctive-coat-color-in-belgian-blue-cattle
#8
Wanbo Li, Arnaud Sartelet, Nico Tamma, Wouter Coppieters, Michel Georges, Carole Charlier
In the course of a reverse genetic screen in the Belgian Blue cattle breed, we uncovered a 10-bp deletion (c.87_96del) in the first coding exon of the melanophilin gene (MLPH), which introduces a premature stop codon (p.Glu32Aspfs*1) in the same exon, truncating 94% of the protein. Recessive damaging mutations in the MLPH gene are well known to cause skin, hair, coat or plumage color dilution phenotypes in numerous species, including human, mice, dog, cat, mink, rabbit, chicken and quail. Large-scale array genotyping undertaken to identify p...
February 2016: Animal Genetics
https://www.readbyqxmd.com/read/26276051/treatment-of-canine-atopic-dermatitis-2015-updated-guidelines-from-the-international-committee-on-allergic-diseases-of-animals-icada
#9
Thierry Olivry, Douglas J DeBoer, Claude Favrot, Hilary A Jackson, Ralf S Mueller, Tim Nuttall, Pascal Prélaud
BACKGROUND: In 2010, the International Task Force on Canine Atopic Dermatitis (now International Committee on Allergic Diseases of Animals, ICADA) published the first consensus guidelines for the treatment of atopic dermatitis (AD) in dogs. This is the first 5-year minor update of this document. RESULTS: The treatment of acute flares of AD should involve the search for, and then elimination of, the cause of the flares, bathing with mild shampoos, and controlling pruritus and skin lesions with interventions that include topical and/or oral glucocorticoids or oclacitinib...
2015: BMC Veterinary Research
https://www.readbyqxmd.com/read/26175132/microneedling-as-a-successful-treatment-for-alopecia-x-in-two-pomeranian-siblings
#10
Steve Stoll, Christian Dietlin, Claudia S Nett-Mettler
BACKGROUND: Alopecia X (hair cycle arrest) is a relatively frequent hair growth disorder in Pomeranians and several other breeds, characterized by symmetrical, noninflammatory alopecia without systemic signs. The cause and pathogenesis remain unknown. Previously reported treatments with various topical and systemic drugs have been variably successful. HYPOTHESIS: We hypothesized that superficial mechanical skin trauma applied with a microneedling device would induce long-term hair regrowth at treated sites...
October 2015: Veterinary Dermatology
https://www.readbyqxmd.com/read/26104920/generalized-vitiligo-in-a-dog-with-primary-hypoadrenocorticism
#11
Eleonora Malerba, Maria Morini, Federico Fracassi
BACKGROUND: Vitiligo is presumed to be an autoimmune disorder in the dog; primary adrenal insufficiency (Addison's disease) is associated with immune-mediated destruction of the adrenal cortex. HYPOTHESIS/OBJECTIVES: In this case report we describe a dog with primary hypoadrenocorticism that developed generalized vitiligo. CASE REPORT: A 4-year-old spayed female cross-bred dog developed signs of Addison's disease and this was confirmed by biochemical testing; the dog was treated with fludrocortisone acetate and then desoxycorticosterone pivalate...
October 2015: Veterinary Dermatology
https://www.readbyqxmd.com/read/26043131/evaluation-of-marketing-claims-ingredients-and-nutrient-profiles-of-over-the-counter-diets-marketed-for-skin-and-coat-health-of-dogs
#12
Lily N Johnson, Cailin R Heinze, Deborah E Linder, Lisa M Freeman
OBJECTIVE: To evaluate marketing claims, ingredients, and nutrient profiles of over-the-counter diets marketed for skin and coat health of dogs. DESIGN: Cross-sectional study. SAMPLE: 24 over-the-counter dry and canned diets marketed for skin and coat health of dogs. PROCEDURES: Data on marketing claims and ingredients were collected from diet packaging and manufacturer websites. Concentrations of selected nutrients were obtained by contacting the manufacturers and were compared against minimum values for Association of American Feed Control Officials Dog Food Nutrient Profiles for adult dog maintenance based on calorie content...
June 15, 2015: Journal of the American Veterinary Medical Association
https://www.readbyqxmd.com/read/25881320/efficacy-of-orally-administered-fluralaner-bravecto%C3%A2-or-topically-applied-imidacloprid-moxidectin-advocate%C3%A2-against-generalized-demodicosis-in-dogs
#13
RANDOMIZED CONTROLLED TRIAL
Josephus J Fourie, Julian E Liebenberg, Ivan G Horak, Janina Taenzler, Anja R Heckeroth, Regis Frénais
BACKGROUND: This laboratory study compared the efficacy of Bravecto™ (fluralaner), formulated as a chewable tablet, with the efficacy of Advocate® (imidacloprid/moxidectin), formulated for topical administration, against naturally acquired generalized demodicosis in dogs. METHODS: Sixteen dogs, all diagnosed with generalized demodectic mange, were randomly allocated to two equal groups. Bravecto™ chewable tablets were administered once orally at a minimum dose of 25 mg fluralaner/kg body weight to one group of dogs, while the second group was treated topically on three occasions at 28-day intervals with Advocate® at a minimum dose of 10 mg imidacloprid/kg body weight and 2...
2015: Parasites & Vectors
https://www.readbyqxmd.com/read/25545298/comparative-assessment-of-a-canine-specific-medium-to-support-colony-formation-from-canine-hair-follicular-keratinocytes
#14
COMPARATIVE STUDY
Dominique J Wiener, Marcus G Doherr, Eliane J Müller, Maja M Suter, Monika M Welle
BACKGROUND: Follicular stem cells and their progeny are responsible for the cyclical renewal of hair follicles and maintenance of the hair coat. The understanding of pathways involved in this process is essential to elucidate the pathogenetic mechanisms of primary alopecia. Stem cells and their direct descendants are located in the bulge region of the isthmus of hair follicles. Although these cells have been studied extensively in mice and humans, data for canine isthmic keratinocyte activation and proliferation are not available...
June 2015: Veterinary Dermatology
https://www.readbyqxmd.com/read/25461481/development-of-a-photoreactive-probe-based-system-for-detecting-heparin
#15
Tomio Yabe, Ritsuko Hosoda-Yabe, Hiroki Sakai, Yoshihiro Kanamaru, Makoto Kiso
We previously identified a peptide heparin-associated peptide Y (HappY) that binds specifically to heparin. In this article, we report a novel heparin detection system using chemically modified HappY as a probe. The photoreactive HappY probe was serially diluted and dispensed into a 96-well plate coated with biotinylated heparin. After ultraviolet irradiation, the HappY probe crosslinked to the heparin on the plate was detected with fluorescein isothiocyanate-conjugated streptavidin. Furthermore, the photoreactive HappY probe was used to stain cutaneous tissue sections obtained from dermatitis-affected or mastocytoma-affected cats and dogs...
March 1, 2015: Analytical Biochemistry
https://www.readbyqxmd.com/read/25227429/efficacy-of-low-level-laser-therapy-on-hair-regrowth-in-dogs-with-noninflammatory-alopecia-a-pilot-study
#16
Lara Olivieri, Damiano Cavina, Giada Radicchi, Vincenzo Miragliotta, Francesca Abramo
BACKGROUND: Canine noninflammatory alopecia (CNA) is a heterogeneous group of skin diseases with different underlying pathogenesis. The therapeutic approach is challenging, and new options for treatment are desirable. HYPOTHESIS/OBJECTIVES: To test the clinical efficacy of low-level laser therapy (LLLT) on hair regrowth in CNA. ANIMALS: Seven dogs of different ages, breeds and genders with a clinical and histopathological diagnosis of noninflammatory alopecia...
February 2015: Veterinary Dermatology
https://www.readbyqxmd.com/read/25131155/leptin-receptor-is-expressed-by-epidermis-and-skin-appendages-in-dog
#17
Francesca Mercati, Margherita Maranesi, Cecilia Dall'Aglio, Paola Scocco, Luisa Pascucci, Cristiano Boiti, Piero Ceccarelli
Leptin is a polypeptide secreted by adipocytes which binds to a specific receptor (Ob-R) that is expressed in various tissues. The wide distribution of the Ob-R suggests that leptin might exert diverse biological functions, not only by regulating energy metabolism and appetite, but also by acting as a mitogen in many cell types, including keratinocytes. In this study, the presence and localization of Ob-R was investigated in the skin of the dog using RT-PCR and immunohistochemical techniques. RT-PCR revealed the presence of Ob-R m-RNA in the skin specimens collected from the dorsal region of two smooth coat breed dogs...
October 2014: Acta Histochemica
https://www.readbyqxmd.com/read/24986315/spontaneous-acromegaly-a-retrospective-case-control-study-in-german-shepherd-dogs
#18
F Fracassi, L Zagnoli, D Rosenberg, T Furlanello, M Caldin
Acromegaly results from the overproduction of growth hormone in adulthood and is characterised by overgrowth of soft tissue and/or bone as well as insulin resistance. There are few data indicating the risk factors associated with this disease in dogs or its clinicopathological features and sequelae. The objective of this retrospective study was to catalogue and assess these aspects of the disease in German shepherd dogs (GSDs) which were found to be over-represented among acromegalic dogs attending two veterinary referral clinics over a period of 7 years...
October 2014: Veterinary Journal
https://www.readbyqxmd.com/read/24680602/the-immuno-pathological-conversions-of-canine-demodicosis
#19
REVIEW
Shanker K Singh, Umesh Dimri
Canine demodicosis is a common but exigent noncontagious parasitic dermatosis caused by overpopulation of the host-specific follicular mites of various Demodex species. Receptivity of dogs to demodicosis and progression of the clinical disease are influenced by numerous factors including; genetic defect, alteration of skin's structure and biochemistry, immunological disorders, hormonal status, breed, age, nutritional status, oxidative stress, length of hair coat, stage of oestrus cycle, parturition, endoparasitism and debilitating diseases...
June 16, 2014: Veterinary Parasitology
https://www.readbyqxmd.com/read/24458920/in-vitro-and-in-vivo-experiments-with-iron-oxide-nanoparticles-functionalized-with-dextran-or-polyethylene-glycol-for-medical-applications-magnetic-targeting
#20
M L Mojica Pisciotti, E Lima, M Vasquez Mansilla, V E Tognoli, H E Troiani, A A Pasa, T B Creczynski-Pasa, A H Silva, P Gurman, L Colombo, G F Goya, A Lamagna, R D Zysler
In this research work, DEXTRAN- and polyethylene glycol (PEG)-coated iron-oxide superparamagnetic nanoparticles were synthetized and their cytotoxicity and biodistribution assessed. Well-crystalline hydrophobic Fe3 O4 SPIONs were formed by a thermal decomposition process with d = 18 nm and σ = 2 nm; finally, the character of SPIONs was changed to hydrophilic by a post-synthesis procedure with the functionalization of the SPIONs with PEG or DEXTRAN. The nanoparticles present high saturation magnetization and superparamagnetic behavior at room temperature, and the hydrodynamic diameters of DEXTRAN- and PEG-coated SPIONs were measured as 170 and 120 nm, respectively...
May 2014: Journal of Biomedical Materials Research. Part B, Applied Biomaterials
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