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https://www.readbyqxmd.com/read/27863277/vitamin-d-supplementation-affects-the-igf-system-in-men-after-acute-exercise
#1
Rachel L Darr, Kathleen J Savage, Mark Baker, Gregory E Wilding, Amy Raswalsky, Todd Rideout, Richard W Browne, Peter J Horvath
OBJECTIVE: Contradictory data between the Insulin-Like Growth Factor System (IGF) system and exercise may be due to alteration in IGF binding proteins. Vitamin D (D) deficiency has been related to muscle weakness and Insulin Like Growth Factor Binding Protein 3 (IGFBP3). A Vit. D and acute exercise merge is proposed to modify the IGF system. DESIGN: D insufficient and deficient men (39.0±8.6yo with serum D (25OH D) 20.0±7.7ng/mL) did 1h of stretching (ST), aerobic (AB), and resistance (RT) exercises, before and after 28d of 4000IU/d Vit...
November 5, 2016: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/27834463/gene-expression-profile-of-renal-cell-carcinomas-after-neoadjuvant-treatment-with-sunitinib-new-pathways-revealed
#2
Carlos Dzik, Sabrina T Reis, Nayara I Viana, Glauber Brito, Isis Paloppi, Willian Nahas, Miguel Srougi, Katia R M Leite
BACKGROUND: In renal cell carcinoma (RCC) of the clear cell type, inactivity of the VHL gene induces overexpression of HIF1 α and its targets, the tyrosine kinase receptors, promoting RCC development and progression. The discovery of tyrosine kinase inhibitors (TKIs) changed the treatment of these tumors. Other molecular pathways involved in the TKI mechanisms of action have not been described in the literature. The aim of our study was to elucidate alternative mechanisms of action of sunitinib in tumor tissue after neoadjuvant treatment of RCC...
November 1, 2016: International Journal of Biological Markers
https://www.readbyqxmd.com/read/27795999/effects-of-the-insulin-like-growth-factor-pathway-on-the-regulation-of-mammary-gland-development
#3
REVIEW
Woo Tae Ha, Ha Yeon Jeong, Seung Yoon Lee, Hyuk Song
The insulin-like growth factor (IGF) pathway is a key signal transduction pathway involved in cell proliferation, migration, and apoptosis. In dairy cows, IGF family proteins and binding receptors, including their intracellular binding partners, regulate mammary gland development. IGFs and IGF receptor interactions in mammary glands influence the early stages of mammogenesis, i.e., mammary ductal genesis until puberty. The IGF pathway includes three major components, IGFs (such as IGF-I, IGF-II, and insulin), their specific receptors, and their high-affinity binding partners (IGF binding proteins [IGFBPs]; i...
September 2016: Balsaeng'gwa Saengsig
https://www.readbyqxmd.com/read/27696687/phosphatidic-acid-induces-decidualization-by-stimulating-akt-pp2a-binding-in-human-endometrial-stromal-cells
#4
So Young Lee, Yun Young Lee, Joong Sub Choi, Mee-Sup Yoon, Joong-Soo Han
Decidualization of human endometrial stromal cells (hESCs) is crucial for successful uterine implantation and maintaining pregnancy. We previously reported that phospholipase D1 (PLD1) is required for cAMP-induced decidualization of hESCs. However, the mechanism by which phosphatidic acid (PA), the product of PLD1 action, might regulate decidualization is not known. We confirmed that PA induced decidualization of hESCs by observing morphological changes and measuring increased levels of decidualization markers such as IGFBP1 and prolactin transcripts (P < 0...
November 2016: FEBS Journal
https://www.readbyqxmd.com/read/27628219/low-body-mass-index-in-endometriosis-is-promoted-by-hepatic-metabolic-gene-dysregulation-in-mice
#5
Laura G Goetz, Ramanaiah Mamillapalli, Hugh S Taylor
The gynecological disease endometriosis is characterized by the deposition and proliferation of endometrial cells outside the uterus and clinically is linked to low body mass index (BMI). Gene expression in the liver of these women has not been reported. We hypothesized that endometriosis may impact hepatic gene expression, promoting a low BMI. To determine the effect of endometriosis on liver gene expression, we induced endometriosis in female mice by suturing donor mouse endometrium into the peritoneal cavity and measuring the weight of these mice...
December 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27628217/igfbp1-involved-in-the-decreased-birth-weight-due-to-fetal-high-estrogen-exposure-in-mice
#6
Min Jin, Ping-Ping Lv, Tian-Tian Yu, Jin-Ming Shen, Chun Feng, He-Feng Huang
Our previous study indicated that maternal high estrogen environment in the first trimester is correlated with increased risks of low birth weight (LBW) and adult diseases. The present study aimed to establish an animal model to confirm such an effect in mice; and to further explore 5 the mechanism involved. A mouse model with high estradiol (E2) exposure during early pregnancy was established, and the birth weight, growth after birth, and expression levels of insulin-like growth factor binding protein 1 (IGFBP1) of pups were examined, respectively...
September 14, 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27619487/transcriptional-regulation-of-genes-involved-in-retinoic-acid-metabolism-in-senegalese-sole-larvae
#7
Anaïs Boglino, Marian Ponce, Xavier Cousin, Enric Gisbert, Manuel Manchado
The aim of this study was the characterization of transcriptional regulatory pathways mediated by retinoic acid (RA) in Senegalese sole larvae. For this purpose, pre-metamorphic larvae were treated with a low concentration of DEAB, an inhibitor of RALDH enzyme, until the end of metamorphosis. No differences in growth, eye migration or survival were observed. Nevertheless, gene expression analysis revealed a total of 20 transcripts differentially expressed during larval development and only six related with DEAB treatments directly involved in RA metabolism and actions (rdh10a, aldh1a2, crbp1, igf2r, rarg and cyp26a1) to adapt to a low-RA environment...
September 10, 2016: Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
https://www.readbyqxmd.com/read/27615428/withdrawn-emodin-increases-expression-of-insulin-like-growth-factor-binding-protein-1-through-activation-of-mek-erk-ampk%C3%AE-and-interaction-of-ppar%C3%AE-and-sp1-in-lung-cancer
#8
Qing Tang, JingJing Wu, Fang Zheng, YuQing Chen, Swei Sunny Hann
This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.
September 9, 2016: Biochimica et Biophysica Acta
https://www.readbyqxmd.com/read/27604954/nm23-regulates-decidualization-through-the-pi3k-akt-mtor-signaling-pathways-in-mice-and-humans
#9
Xue Zhang, Li-Juan Fu, Xue-Qing Liu, Zhuo-Ying Hu, Yu Jiang, Ru-Fei Gao, Qian Feng, Xi Lan, Yan-Qing Geng, Xue-Mei Chen, Jun-Lin He, Ying-Xiong Wang, Yu-Bin Ding
STUDY QUESTION: Does nm23 have functional significance in decidualization in mice and humans? SUMMARY ANSWER: nm23 affects decidualization via the phosphoinositide 3 kinase/mammalian target of rapamycin (PI3K-Akt-mTOR) signaling pathways in mouse endometrial stromal cells (ESCs; mESCs) and human ESCs. WHAT IS KNOWN ALREADY: The function of nm23 in suppressing metastasis has been demonstrated in a variety of cancer types. nm23 also participates in the control of DNA replication and cell proliferation and differentiation...
October 2016: Human Reproduction
https://www.readbyqxmd.com/read/27516442/igfbp1-increases-%C3%AE-cell-regeneration-by-promoting-%C3%AE-to-%C3%AE-cell-transdifferentiation
#10
Jing Lu, Ka-Cheuk Liu, Nadja Schulz, Christos Karampelias, Jérémie Charbord, Agneta Hilding, Linn Rautio, Philippe Bertolino, Claes-Göran Östenson, Kerstin Brismar, Olov Andersson
There is great interest in therapeutically harnessing endogenous regenerative mechanisms to increase the number of β cells in people with diabetes. By performing whole-genome expression profiling of zebrafish islets, we identified 11 secreted proteins that are upregulated during β-cell regeneration. We then tested the proteins' ability to potentiate β-cell regeneration in zebrafish at supraphysiological levels. One protein, insulin-like growth factor (Igf) binding-protein 1 (Igfbp1), potently promoted β-cell regeneration by potentiating α- to β-cell transdifferentiation...
September 15, 2016: EMBO Journal
https://www.readbyqxmd.com/read/27465134/the-study-of-cyclooxygenase-2-in-human-decidua-of-preeclampsia
#11
Dongmei Zhang, Xinlian Chang, Jing Bai, Zi-Jiang Chen, Wei-Ping Li, Cong Zhang
Preeclampsia (PE), a pregnancy-specific disorder characterized by hypertension and proteinuria beginning after 20 wk of pregnancy, is a major cause of maternal and fetal morbidity and mortality. Delivery of the placenta reverses the immediate clinical manifestations and remains the only reliable treatment for PE. Up to now, the causes of PE are not entirely clear. Human cyclooxygenase 2 (COX2, encoded by PTGS2) is a highly inducible enzyme and regulates inflammation, differentiation, mitogenesis, and angiogenesis...
September 2016: Biology of Reproduction
https://www.readbyqxmd.com/read/27432359/murine-uterine-decidualization-is-a-novel-function-of-autoimmune-regulator-beyond-immune-tolerance
#12
Vasanthi Soumya, Renjini A Padmanabhan, Shiny Titus, Malini Laloraya
PROBLEM: Autoimmune polyendocrinopathy, candidiasis, and ectodermal dystrophy (APECED, APS-1) patients characterized by Aire (autoimmune regulator) mutations and Aire homozygous knockouts (Aire(-/-) ) exhibit infertility. It is not clear as to what contributes to infertility in the above. METHOD OF STUDY: This study investigates the expression of "AIRE in the uterus" and its contribution to early pregnancy of mice by using quantitative real-time PCR analysis, immunohistochemistry, Western blotting, and in vivo Aire silencing experiments...
September 2016: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/27404283/serum-proteomic-profiles-of-depressive-subtypes
#13
F Lamers, M Bot, R Jansen, M K Chan, J D Cooper, S Bahn, B W J H Penninx
Depression is a highly heterogeneous disorder. Accumulating evidence suggests biological and genetic differences between subtypes of depression that are homogeneous in symptom presentation. We aimed to evaluate differences in serum protein profiles between persons with atypical and melancholic depressive subtypes, and compare these profiles with serum protein levels of healthy controls. We used the baseline data from the Netherlands Study of Depression and Anxiety on 414 controls, 231 persons with a melancholic depressive subtype and 128 persons with an atypical depressive subtype for whom the proteomic data were available...
2016: Translational Psychiatry
https://www.readbyqxmd.com/read/27320917/hepatic-fatty-acid-oxidation-restrains-systemic-catabolism-during-starvation
#14
Jieun Lee, Joseph Choi, Susanna Scafidi, Michael J Wolfgang
The liver is critical for maintaining systemic energy balance during starvation. To understand the role of hepatic fatty acid β-oxidation on this process, we generated mice with a liver-specific knockout of carnitine palmitoyltransferase 2 (Cpt2(L-/-)), an obligate step in mitochondrial long-chain fatty acid β-oxidation. Fasting induced hepatic steatosis and serum dyslipidemia with an absence of circulating ketones, while blood glucose remained normal. Systemic energy homeostasis was largely maintained in fasting Cpt2(L-/-) mice by adaptations in hepatic and systemic oxidative gene expression mediated in part by Pparα target genes including procatabolic hepatokines Fgf21, Gdf15, and Igfbp1...
June 28, 2016: Cell Reports
https://www.readbyqxmd.com/read/27315566/cooperative-effects-of-hepatitis-b-virus-and-tnf-may-play-important-roles-in-the-activation-of-metabolic-pathways-through-the-activation-of-nf-%C3%AE%C2%BAb
#15
Shuang Wu, Tatsuo Kanda, Shingo Nakamoto, Xia Jiang, Masato Nakamura, Reina Sasaki, Yuki Haga, Hiroshi Shirasawa, Osamu Yokosuka
Elevated levels of inflammatory cytokines such as tumor necrosis factor-α (TNF-α) and interleukin (IL)-1β are often observed in the sera of hepatitis B virus (HBV)-infected patients. It is well known that these cytokines activate nuclear factor-κB (NF-κB)-signaling, and are associated with endoplasmic reticulum (ER) stress. We investigated whether HBV or HBV X protein (HBx) enhanced the activation of NF-κB in the presence of TNF and/or IL-1β, and their effects on the expression of metabolic pathway‑associated genes...
August 2016: International Journal of Molecular Medicine
https://www.readbyqxmd.com/read/27226639/hepatic-aryl-hydrocarbon-receptor-attenuates-fibroblast-growth-factor-21-expression
#16
Nathaniel G Girer, Iain A Murray, Curtis J Omiecinski, Gary H Perdew
The Aryl hydrocarbon receptor (AHR) is a ligand-activated transcription factor involved in many physiological processes. Several studies indicate that AHR is also involved in energy homeostasis. Fibroblast growth factor 21 (FGF21) is an important regulator of the fasting and feeding responses. When administered to various genetic and diet-induced mouse models of obesity, FGF21 can attenuate obesity-associated morbidities. Here, we explore the role of AHR in hepatic Fgf21 expression through the use of a conditional, hepatocyte-targeted AHR knock-out mouse model (Cre(Alb)Ahr(Fx/Fx))...
July 15, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27225428/assessing-the-role-of-insulin-like-growth-factors-and-binding-proteins-in-prostate-cancer-using-mendelian-randomization-genetic-variants-as-instruments-for-circulating-levels
#17
Carolina Bonilla, Sarah J Lewis, Mari-Anne Rowlands, Tom R Gaunt, George Davey Smith, David Gunnell, Tom Palmer, Jenny L Donovan, Freddie C Hamdy, David E Neal, Rosalind Eeles, Doug Easton, Zsofia Kote-Jarai, Ali Amin Al Olama, Sara Benlloch, Kenneth Muir, Graham G Giles, Fredrik Wiklund, Henrik Grönberg, Christopher A Haiman, Johanna Schleutker, Børge G Nordestgaard, Ruth C Travis, Nora Pashayan, Kay-Tee Khaw, Janet L Stanford, William J Blot, Stephen Thibodeau, Christiane Maier, Adam S Kibel, Cezary Cybulski, Lisa Cannon-Albright, Hermann Brenner, Jong Park, Radka Kaneva, Jyotsna Batra, Manuel R Teixeira, Hardev Pandha, Mark Lathrop, Richard M Martin, Jeff M P Holly
Circulating insulin-like growth factors (IGFs) and their binding proteins (IGFBPs) are associated with prostate cancer. Using genetic variants as instruments for IGF peptides, we investigated whether these associations are likely to be causal. We identified from the literature 56 single nucleotide polymorphisms (SNPs) in the IGF axis previously associated with biomarker levels (8 from a genome-wide association study [GWAS] and 48 in reported candidate genes). In ∼700 men without prostate cancer and two replication cohorts (N ∼ 900 and ∼9,000), we examined the properties of these SNPS as instrumental variables (IVs) for IGF-I, IGF-II, IGFBP-2 and IGFBP-3...
October 1, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27193429/branched-chain-amino-acids-regulate-insulin-like-growth-factor-binding-protein-1-igfbp1-production-by-decidua-and-influence-trophoblast-migration-through-igfbp1
#18
Kei Tanaka, Keiji Sakai, Miho Matsushima, Yukiko Matsuzawa, Tomoko Izawa, Takashi Nagashima, Seishi Furukawa, Yoichi Kobayashi, Mitsutoshi Iwashita
STUDY QUESTION: Do branched-chain amino acids (BCAAs) influence the migration of human extravillous trophoblast (EVT) cells through changes in insulin-like growth factor-binding protein 1 (IGFBP1) production in decidual cells? STUDY FINDING: Decidua-derived IGFBP1 had a stimulating effect on migration of EVT. WHAT IS KNOWN ALREADY: IGFBP1 is abundantly secreted from human decidual cells and influences trophoblast migration in human placenta of early pregnancy...
August 2016: Molecular Human Reproduction
https://www.readbyqxmd.com/read/27188169/erratum-to-inter-regulation-of-igfbp1-and-foxo3a-unveils-novel-mechanism-in-ursolic-acid-inhibited-growth-of-hepatocellular-carcinoma-cells
#19
LiJun Yang, Qing Tang, Jingjing Wu, Yuqing Chen, Fang Zheng, Zhenhui Dai, Swei Sunny Hann
No abstract text is available yet for this article.
2016: Journal of Experimental & Clinical Cancer Research: CR
https://www.readbyqxmd.com/read/27167772/progesterone-dependent-induction-of-phospholipase-c-related-catalytically-inactive-protein-1-prip-1-in-decidualizing-human-endometrial-stromal-cells
#20
Joanne Muter, Paul J Brighton, Emma S Lucas, Lauren Lacey, Anatoly Shmygol, Siobhan Quenby, Andrew M Blanks, Jan J Brosens
Decidualization denotes the transformation of endometrial stromal cells into specialized decidual cells. In pregnancy, decidual cells form a protective matrix around the implanting embryo, enabling coordinated trophoblast invasion and formation of a functional placenta. Continuous progesterone (P4) signaling renders decidual cells resistant to various environmental stressors, whereas withdrawal inevitably triggers tissue breakdown and menstruation or miscarriage. Here, we show that PLCL1, coding phospholipase C (PLC)-related catalytically inactive protein 1 (PRIP-1), is highly induced in response to P4 signaling in decidualizing human endometrial stromal cells (HESCs)...
July 2016: Endocrinology
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