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https://www.readbyqxmd.com/read/29720512/a-role-for-steroid-sulfatase-in-intracrine-regulation-of-endometrial-decidualisation
#1
Douglas A Gibson, Paul A Foster, Ioannis Simitsidellis, Hilary Critchley, Olympia Kelepouri, Frances Collins, Philippa T Saunders
In women, establishment of pregnancy is dependent upon 'fine-tuning' of the endometrial microenvironment which is mediated by terminal differentiation (decidualisation) of endometrial stromal fibroblasts (ESF). We have demonstrated that intracrine steroid metabolism plays a key role in regulating decidualisation and is essential for time-dependent expression of key factors required for endometrial receptivity. The primary aim of the current study was to determine whether sulfated steroids can act as precursors to bioactive sex steroids during decidualisation...
May 2, 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29702590/insulin-like-growth-factor-igf-system-in-liver-diseases
#2
REVIEW
Agnieszka Adamek, Aldona Kasprzak
Hepatocyte differentiation, proliferation, and apoptosis are affected by growth factors produced in liver. Insulin-like growth factor 1 and 2 (IGF1 and IGF2) act in response to growth hormone (GH). Other IGF family components include at least six binding proteins (IGFBP1 to 6), manifested by both IGFs develop due to interaction through the type 1 receptor (IGF1R). The data based on animal models and/or in vitro studies suggest the role of IGF system components in cellular aspects of hepatocarcinogenesis (cell cycle progression, uncontrolled proliferation, cell survival, migration, inhibition of apoptosis, protein synthesis and cell growth), and show that systemic IGF1 administration can reduce fibrosis and ameliorate general liver function...
April 27, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29663566/mir-27a-3p-and-mir-124-3p-upregulated-in-endometrium-and-serum-from-women-affected-by-chronic-endometritis-are-new-potential-molecular-markers-of-endometrial-receptivity
#3
Cinzia Di Pietro, Salvatore Caruso, Rosalia Battaglia, Marco Iraci Sareri, Alessandro La Ferlita, Fabrizio Strino, Gabriele Bonaventura, Maurizio Di Mauro, Maria Luisa Barcellona, Vincenzo Perciavalle, Michele Purrello, Antonio Cianci
PROBLEM: Chronic endometritis (CE) is usually asymptomatic and different studies demonstrated the relation with infertility and recurrent pregnancy loss. Altered regulation of protein-encoding genes in CE has been demonstrated, but no evidence about the involvement of microRNAs in the pathology is present in literature. METHOD OF STUDY: In the endometrium from 15 women with CE and 15 healthy women, by RT-qPCR single assays, we investigated some microRNAs targeting IL11, CCL4, IGF1, and IGFBP1, which mRNAs had been found differentially expressed in endometrium of women affected by CE...
April 16, 2018: American Journal of Reproductive Immunology: AJRI
https://www.readbyqxmd.com/read/29603380/identification-of-chromatin-accessible-domains-in-non-alcoholic-steatohepatitis-derived-hepatocellular-carcinoma
#4
Mekonnen Lemma Dechassa, Volodymyr Tryndyak, Aline de Conti, Wenming Xiao, Frederick A Beland, Igor P Pogribny
Non-alcoholic steatohepatitis (NASH) is becoming one of the major causes of hepatocellular carcinoma (HCC) in the United States and Western countries; however, the molecular mechanisms associated with NASH-related liver carcinogenesis are not well understood. In the present study, we investigated cancer-associated chromatin alterations using a model that resembles the development of NASH-related HCC in humans. An assay for transposase-accessible chromatin with high throughput sequencing (ATAC-seq) identified 1,677 tumor-specific chromatin-accessible regions in NASH-derived HCC tissue samples...
March 30, 2018: Molecular Carcinogenesis
https://www.readbyqxmd.com/read/29581465/dietary-genistein-supplementation-for-breeders-and-their-offspring-improves-the-growth-performance-and-immune-function-of-broilers
#5
Zengpeng Lv, Hao Fan, Beibei Zhang, Kun Xing, Yuming Guo
Genistein (GEN) is mainly extracted from soy plants and has potential functions as an antioxidant and in promoting immune function and growth. This study evaluated the effects of feeding breeders and their offspring dietary GEN on the immune function and growth performance of broiler chicks. Breeders were assigned to a control diet or GEN diet (control diet +400 mg/kg GEN), and their offspring were fed a control diet or GEN diet (control diet +40 mg/kg GEN). GEN treatment increased the body weight gain, tibial length, tibial width and slaughter performance of broilers and decreased the feed conversion ratio...
March 26, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29463451/starvation-stress-resistance-and-cancer
#6
REVIEW
Roberta Buono, Valter D Longo
Cancer cells are characterized by dysregulation in signal transduction and metabolic pathways leading to increased glucose uptake, altered mitochondrial function, and the evasion of antigrowth signals. Fasting and fasting-mimicking diets (FMDs) provide a particularly promising intervention to promote differential effects in normal and malignant cells. These effects are caused in part by the reduction in IGF-1, insulin, and glucose and the increase in IGFBP1 and ketone bodies, which generate conditions that force cancer cells to rely more on metabolites and factors that are limited in the blood, thus resulting in cell death...
April 2018: Trends in Endocrinology and Metabolism: TEM
https://www.readbyqxmd.com/read/29447340/dysfunction-of-ddit4-in-the-decidua-is-relevant-to-the-pathogenesis-of-preeclampsia
#7
Jieqiong Yang, Yachao Zhang, Jing Tong, Hong Lv, Cong Zhang, Zi-Jiang Chen
Preeclampsia (PE) is a pregnancy-related disorder that occurs after 20 weeks of gestation and affects 3-5% of all human pregnancies worldwide. However, the pathogenesis of PE still remains poorly understood. A deficiency in decidualization is considered a contributing factor to the development of PE. The DNA damage inducible transcript 4 (DDIT4) gene encodes a protein whose main function is inhibiting mammalian target of rapamycin (mTOR) under stress, and several studies have demonstrated that its expression promotes tumor cell apoptosis...
February 13, 2018: Biology of Reproduction
https://www.readbyqxmd.com/read/29438518/obesity-and-high-fat-diet-induce-distinct-changes-in-placental-gene-expression-and-pregnancy-outcome
#8
Erica B Mahany, Xingfa Han, Beatriz C Borges, Sanseray da Silveira Cruz-Machado, Susan J Allen, David Garcia-Galiano, Mark J Hoenerhoff, Nicole H Bellefontaine, Carol F Elias
Obese women are at high risk of pregnancy complications, including preeclampsia, miscarriage, preterm birth, stillbirth, and neonatal death. In the current study, we aimed to determine the effects of obesity on pregnancy outcome and placental gene expression in preclinical mouse models of genetic and nutritional obesity. The leptin receptor (LepR) null-reactivatable (LepRloxTB), LepR-deficient (Leprdb/+), and high-fat diet (HFD)-fed mice were assessed for fertility, pregnancy outcome, placental morphology, and placental transcriptome using standard quantitative polymerase chain reaction (qPCR) and qPCR arrays...
April 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29410193/inflammation-associated-cytokines-igfbp1-and-rantes-impair-the-megakaryocytic-potential-of-hscs-in-pt-patients-after-allo-hsct
#9
Cuicui Liu, Yiqing Yang, Dan Wu, Wenxia Zhang, Hongtao Wang, Pei Su, Jianfeng Yao, Chen Liang, Sizhou Feng, Mingzhe Han, Fuxu Wang, Erlie Jiang, Jiaxi Zhou
Prolonged isolated thrombocytopenia (PT) is a severe complication in patients after allogeneic hematopoietic stem cell transplantation (allo-HSCT). Whether the megakaryoctic potential of hematopoietic stem cells (HSCs) in bone marrow is intact and what factors drive the pathological process of PT remain elusive. A retrospective study in patients (n = 285) receiving HSCT revealed that the occurrence of PT was approximately 8% and the number of platelets and megakaryocytes in PT patients is much lower compared with control subjects...
February 1, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29397924/dehydroepiandrosterone-enhances-decidualization-in-women-of-advanced-reproductive-age
#10
Douglas A Gibson, Ioannis Simitsidellis, Olympia Kelepouri, Hilary O D Critchley, Philippa T K Saunders
OBJECTIVE: To investigate the impact of the androgen precursor dehydroepiandrosterone (DHEA) on the decidualization of human endometrial stromal cells isolated from women of advanced reproductive age. DESIGN: In vitro study. SETTING: University research institute. PATIENT(S): Proliferative phase primary human endometrial stromal fibroblasts (hESFs) were isolated from women of advanced reproductive age (n = 16; mean age, 44...
April 2018: Fertility and Sterility
https://www.readbyqxmd.com/read/29383334/effects-of-toremifene-a-selective-estrogen-receptor-modulator-on-spontaneous-and-stimulated-gh-secretion-igf-i-and-igf-binding-proteins-in-healthy-elderly-subjects
#11
Ferdinand Roelfsema, Rebecca J Yang, Paul Y Takahashi, Dana Erickson, Cyril Y Bowers, Johannes D Veldhuis
Context: Estrogens amplify spontaneous and stimulated growth hormone (GH) secretion, whereas they diminish GH-dependent insulin-like growth factor (IGF)-I in a dose-dependent manner. Selective estrogen receptor modulators (SERMs), including tamoxifen and toremifene, are widely adjunctively used in breast and prostate cancer. Although some endocrine effects of tamoxifen are known, few data are available for toremifene. Objective: To explore sex-dependent effects of toremifene on spontaneous 10-hour overnight GH secretion, followed by GH-releasing hormone-ghrelin stimulation...
February 1, 2018: Journal of the Endocrine Society
https://www.readbyqxmd.com/read/29363568/fkbp51-regulates-decidualization-through-ser473-dephosphorylation-of-akt
#12
Muyun Wei, Ying Gao, Bingru Lu, Yulian Jiao, Xiaowen Liu, Bin Cui, Shengnan Hu, Linying Sun, Shaowei Mao, Jing Dong, Lei Yan, Zijiang Chen, Yueran Zhao
Defective decidualization of human endometrial stromal cells (ESCs) has recently been highlighted as an underlying cause of implantation failure. FK-506-binding protein 51 (FKBP51) has been shown to participate in the steroid hormone response and the protein kinase B (AKT) regulation process, both of which are important pathways involved in decidualization. The objective of the present study was to investigate the potential effects and mechanisms of FKBP51 in the regulation of ESC decidualization. By performing immunohistochemical staining on an endometrial tissue microarray (TMA) derived from normal females, we found that FKBP51 expression was much higher in the luteal phase than in the follicular phase in ESCs...
March 2018: Reproduction: the Official Journal of the Society for the Study of Fertility
https://www.readbyqxmd.com/read/29273681/sorcin-is-involved-during-embryo-implantation-via-activating-vegf-pi3k-akt-pathway-in-mice
#13
Kanchan Gupta, Vijay Kumar Sirohi, Suparna Kumari, Vinay Shukla, Murli Manohar, Pooja Popli, Anila Dwivedi
Our earlier studies have demonstrated the cyclic variation and also the altered expression of sorcin in endometrium during early-to-mid-secretory phase transition in women with unexplained infertility. The current study was undertaken to establish the functional role of sorcin in endometrial receptivity in mice. Results indicated that sorcin was highly expressed during the window of implantation in mice and functional blockage of sorcin caused significant reduction in number of implanted blastocyst. The receptivity markers (i...
February 2018: Journal of Molecular Endocrinology
https://www.readbyqxmd.com/read/29259466/overexpression-of-microrna-542-3p-attenuates-the-differentiating-capacity-of-endometriotic-stromal-cells
#14
Shamima Sultana, Takeshi Kajihara, Yumi Mizuno, Tomomi Sato, Tatsuo Oguro, Machiko Kimura, Masumi Akita, Osamu Ishihara
Aim: Endometriosis is defined as the presence of endometrial glandular and stromal cells outside of the uterine cavity. A previous study reported that microRNA (miR)-542-3p plays a critical role in eutopic endometrial decidualization. This study aims to clarify the potential role of miR-542-3p and the target gene, IGFBP-1 (insulin-like growth factor-binding protein 1), in the impairment of the decidualizing capacity of human ectopic endometrial stromal cells (HEcESCs). Methods: In vitro analysis of primary undifferentiated and decidualizing human eutopic endometrial stromal cells (HEuESCs) and HEcESCs was conducted...
April 2017: Reproductive Medicine and Biology
https://www.readbyqxmd.com/read/29248211/influence-of-ad-libitum-milk-replacer-feeding-and-butyrate-supplementation-on-the-systemic-and-hepatic-insulin-like-growth-factor-i-and-its-binding-proteins-in-holstein-calves
#15
D Frieten, C Gerbert, C Koch, G Dusel, K Eder, A Hoeflich, B Mielenz, H M Hammon
Ad libitum milk feeding and butyrate (B) supplementation have the potential to stimulate postnatal growth and development in calves. The somatotropic axis is the main endocrine regulator of postnatal growth and may be affected by both ad libitum milk replacer (MR) feeding and B supplementation in calves. We hypothesized that ad libitum MR feeding and B supplementation stimulate systemic and hepatic insulin-like growth factor (IGF)-I and IGF binding proteins (IGFBP) in preweaning calves. Sixty-four (32 male, 32 female) Holstein calves were examined from birth until wk 11 of life...
February 2018: Journal of Dairy Science
https://www.readbyqxmd.com/read/29186427/insulinlike-growth-factor-binding-protein-1-improves-vascular-endothelial-repair-in-male-mice-in-the-setting-of-insulin-resistance
#16
Amir Aziz, Natalie J Haywood, Paul A Cordell, Jess Smith, Nadira Y Yuldasheva, Anshuman Sengupta, Noman Ali, Ben N Mercer, Romana S Mughal, Kirsten Riches, Richard M Cubbon, Karen E Porter, Mark T Kearney, Stephen B Wheatcroft
Insulin resistance is associated with impaired endothelial regeneration in response to mechanical injury. We recently demonstrated that insulinlike growth factor-binding protein-1 (IGFBP1) ameliorated insulin resistance and increased nitric oxide generation in the endothelium. In this study, we hypothesized that IGFBP1 would improve endothelial regeneration and restore endothelial reparative functions in the setting of insulin resistance. In male mice heterozygous for deletion of insulin receptors, endothelial regeneration after femoral artery wire injury was enhanced by transgenic expression of human IGFBP1 (hIGFBP1)...
February 1, 2018: Endocrinology
https://www.readbyqxmd.com/read/29141853/the-effects-of-resistance-exercise-on-biomarkers-of-breast-cancer-prognosis-a-pooled-analysis-of-three-randomized-trials
#17
Kerri M Winters-Stone, Lisa J Wood, Sydnee Stoyles, Nathan F Dieckmann
Background: Using a secondary data analysis from randomized controlled trials comparing one year of resistance exercise ( n = 109) to a placebo control condition ( n = 106) in postmenopausal, posttreatment breast cancer survivors, we investigated the influence of resistance training and changes in body composition on markers associated with cancer progression. Methods: Measures included serum levels of insulin, IGF-1, IGFBP1-3, leptin, serum amyloid A (SAA), adiponectin, C-reactive protein (CRP), IL1β, TNFα, IL6, and IL8, and body composition (total, lean and fat mass in kg) by DXA at baseline, 6, and 12 months...
February 2018: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/29131315/txndc5-contributes-to-rheumatoid-arthritis-by-down-regulating-igfbp1-expression
#18
J Li, B Xu, C Wu, X Yan, L Zhang, X Chang
The thioredoxin domain-containing 5 (TXNDC5) gene is associated with susceptibility to rheumatoid arthritis (RA) and exhibits increased expression in the synovial tissues. TXNDC5 is also associated strongly with diabetes, a metabolic disease characterized by interrupted insulin signalling. This study investigated whether TXNDC5 contributes to RA via the insulin signalling pathway. In this study, RA synovial fibroblast-like cells (RASFs) transfected with an anti-TXNDC5 small interfering RNA (siRNA) were analysed with an insulin signaling pathway RT2 profiler polymerase chain reaction (PCR) array and an insulin resistance RT2 profiler PCR array...
April 2018: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/29108879/remyelination-modulators-in-multiple-sclerosis-patients
#19
Rabeah Al-Temaimi, Jehad AbuBaker, Irina Al-Khairi, Raed Alroughani
Multiple Sclerosis (MS) is a complex autoimmune neuro-inflammatory disorder characterized by persistent MS plaques in the central nervous system. Resolution of MS plaques is dependent on the remyelination competence of surviving oligodendrocytes and surrounding environment. Here, we assessed myelination modulators in a 100 MS patients against 77 healthy controls. Plasma fractions were used for the assessment of insulin growth factor binding protein1 (IGFBP1), brain-derived neurotrophic factor (BDNF), and lipocalin2 (LCN2) using a Luminex multiplex assay, whereas neurofilament light chain (NF-L) was assessed with an enzyme-linked immunosorbent assay...
December 2017: Experimental and Molecular Pathology
https://www.readbyqxmd.com/read/29100429/association-study-of-igfbp1-and-igfbp3-polymorphisms-with-hypertension-and-cardio-cerebral-vascular-diseases-in-a-chinese-han-population
#20
Zhengmei Fang, Song Yang, Lijun Zhu, Ying Li, Yanchun Chen, Yuelong Jin, Xianghai Zhao, Hailong Zhao, Xiaotian Chen, Yanping Zhao, Chong Shen, Yingshui Yao
Previous studies have showed that insulin-like growth factor (IGF) axis is involved in the development of hypertension. It is unclear whether genetic variants in the IGF-binding proteins (IGFBPs) contribute to the susceptibility to hypertension. Three single-nucleotide polymorphisms (SNPs) in IGFBP1 and four SNPs in IGFBP3 were selected for genotyping in 2,012 hypertension cases and 2,210 healthy controls and 4,128 subjects were followed up for a median of 5.01 years. Multiple logistic regression and Cox regression were performed to evaluate the association of these seven SNPs with hypertension and cardio-cerebral vascular disease (CCVD)...
September 29, 2017: Oncotarget
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