Ali R Rezai, James J Mahoney, Manish Ranjan, Marc W Haut, Wanhong Zheng, Laura R Lander, James H Berry, Daniel L Farmer, Jennifer L Marton, Padma Tirumalai, Ashley Mears, Daisy G Y Thompson-Lake, Victor S Finomore, Pierre-François D'Haese, Will M Aklin, David T George, John D Corrigan, Sally L Hodder
OBJECTIVE: There were more than 107,000 drug overdose deaths in the US in 2021, the most ever recorded. Despite advances in behavioral and pharmacological treatments, over 50% of those receiving treatment for opioid use disorder (OUD) experience drug use recurrence (relapse). Given the prevalence of OUD and other substance use disorders (SUDs), the high rate of drug use recurrence, and the number of drug overdose deaths, novel treatment strategies are desperately needed. The objective of this study was to evaluate the safety and feasibility of deep brain stimulation (DBS) targeting the nucleus accumbens (NAc)/ventral capsule (VC) and potential impact on outcomes in individuals with treatment-refractory OUD...
January 1, 2024: Journal of Neurosurgery