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https://www.readbyqxmd.com/read/29325553/sitagliptin-improved-glucose-assimilation-in-detriment-of-fatty-acid-utilization-in-experimental-type-ii-diabetes-role-of-glp-1-isoforms-in-glut4-receptor-trafficking
#1
E Ramírez, B Picatoste, A González-Bris, M Oteo, F Cruz, A Caro-Vadillo, J Egido, J Tuñón, M A Morcillo, Ó Lorenzo
BACKGROUND: The distribution of glucose and fatty-acid transporters in the heart is crucial for energy consecution and myocardial function. In this sense, the glucagon-like peptide-1 (GLP-1) enhancer, sitagliptin, improves glucose homeostasis but it could also trigger direct cardioprotective actions, including regulation of energy substrate utilization. METHODS: Type-II diabetic GK (Goto-Kakizaki), sitagliptin-treated GK (10 mg/kg/day) and wistar rats (n = 10, each) underwent echocardiographic evaluation, and positron emission tomography scanning for [18F]-2-fluoro-2-deoxy-D-glucose (18FDG)...
January 11, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29287785/evaluation-of-muscle-activity-just-after-straight-leg-raising-exercise-by-using-18fdg-pet
#2
Hiroyuki Shiozawa, Takashi Ohsawa, Yoshito Tsushima, Tetsuya Higuchi, Kenji Takagishi, Hirotaka Chikuda
BACKGROUND: Exercise therapy is one of the recognized treatment methods for knee osteoarthritis (KOA). One such exercise technique, straight leg raising (SLR), is widely known as a home exercise method for strengthening the quadriceps femoris muscle. However, whether this exercise truly strengthens the quadriceps is not known. The objective of the present study was to investigate which lower limb muscle is stimulated and shows increased activity with SLR. METHODS: A total of 14 lower limbs in seven healthy adult male volunteers (mean age: 31...
December 26, 2017: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29273076/highly-conformal-combined-radiotherapy-with-cisplatin-and-gemcitabine-for-treatment-of-loco-regionally-advanced-cervical-cancer-a-retrospective-study
#3
Nikola Cihoric, Alexandros Tsikkinis, Eugenia Vlaskou Badra, Markus Glatzer, Urban Novak, Amina Scherz, Mohamed Shelan, Ivan Soldatovic, Chittazhathu Kurian Kuruvilla Yojena, Daniel M Aebersold, Kristina Lössl
BACKGROUND: Cisplatin and gemcitabine combined with conventional radiation therapy in the treatment of cervical cancer patients results in a favorable outcome but with excess toxicity. The purpose of this study was to evaluate the toxicity profile of dual chemotherapy and highly conformal external beam radiotherapy with image guided adaptive brachytherapy. METHODS: Seventeen patients with cervical carcinoma FIGO stage IB2-IIIB were treated with curative intent between 2011 and 2015...
December 22, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29261622/18fdg-pet-ct-for-the-visualization-of-inflammatory-component-of-radiation-induced-lung-injury-after-stereotactic-radiotherapy
#4
Olarn Roengvoraphoj, Montserrat Pazos-Escudero, Chukwuka Eze, Maurice Dantes, Farkhad Manapov
Visualization and metabolic analysis of acute inflammation in the lung parenchyma plays a crucial role for the prediction and diagnosis of radiation-induced lung injury and is particularly important in medically inoperable patients because of a priori very limited pulmonary function. This case confirms that a radiation-induced lung injury is accompanied by acute inflammatory reaction in the lung parenchyma irradiated with a total dose of 12-40 Gy. This well-defined inflammation component could be exactly characterized with FDG-PET/CT...
December 19, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29231148/pet-radiopharmaceuticals-in-brazil-and-belarus-economic-comparison-using-the-case-of-18fdg
#5
Sviatoslav Brinkevich, Leonardo Paredes Pires, Filipe Leal Portilho, Ralph Santos-Oliveira
The production of radiopharmaceuticals, especially the PET ones, is a complex combination of economic and social factors. Despite the social aspects, that are essential, the economic issue must be considered and play an important parameter for the implementation and maintenance of producer centers around the world, with especial regards for countries which face economic crisis and/or belongs to aegis of under development countries. In order to evaluate this scenario with carried out this study, comparing a well-established producer center in Brazil and a new on in Belarus...
December 11, 2017: Current Radiopharmaceuticals
https://www.readbyqxmd.com/read/29204718/superiority-of-68ga-dotatate-over-18f-fdg-and-anatomic-imaging-in-the-detection-of-succinate-dehydrogenase-mutation-sdhx-related-pheochromocytoma-and-paraganglioma-in-the-pediatric-population
#6
Abhishek Jha, Alexander Ling, Corina Millo, Garima Gupta, Bruna Viana, Frank I Lin, Peter Herscovitch, Karen T Adams, David Taïeb, Adam R Metwalli, W Marston Linehan, Alessandra Brofferio, Constantine A Stratakis, Electron Kebebew, Maya Lodish, Ali Cahid Civelek, Karel Pacak
PURPOSE: To evaluate and compare diagnostic performance of 68Ga-DOTA(0)-Tyr(3)-octreotate (68Ga-DOTATATE) with 18F-fluoro-2-deoxy-D-glucose (18F-FDG) positron emission tomography-computed tomography (PET/CT) and anatomic imaging using computed tomography and/or magnetic resonance (CT/MR) imaging in detection of SDHx-related pheochromocytomas and paragangliomas (PPGLs) in pediatric patients. METHODS: Nine pediatric patients (5:4, girls:boys; 14.6 ± 2.0 years) with an SDHx-related mutation (SDHB:SDHA:SDHD, n = 7:1:1) were included in this retrospective study...
December 4, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/29203290/patterns-of-locoregional-failure-in-locally-advanced-non-small-cell-lung-cancer-treated-with-definitive-conformal-radiotherapy-results-from-the-gating-2006-trial
#7
Emmanuel Jouglar, Vanina Isnardi, Dorothée Goulon, Céline Ségura-Ferlay, Myriam Ayadi, Claire Dupuy, Jean-Yves Douillard, Marc-André Mahé, Line Claude
PURPOSE: To determine the patterns of locoregional failure (LRF) in patients with locally advanced non-small cell lung cancer treated with definitive radiotherapy (RT). PATIENTS AND METHODS: One hundred and fifty-four patients from the Gating 2006 prospective randomized trial were treated with conformal RT with or without respiratory motion management. For patients with a LRF as first event, treatment planning with simulation CT, pre-treatment 18FDG PET-CT and post-treatment images demonstrating recurrence were registered and analyzed...
December 1, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29198183/18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-imaging-in-hiv-infected-patients-with-lymphadenopathy-with-or-without-fever-and-or-splenomegaly
#8
L Jain, S Mackenzie, J B Bomanji, R Shortman, M Noursadeghi, S G Edwards, R F Miller
We audited whether 18F-Fluorodeoxyglucose positron emission tomography-computed tomography (18FDG PET-CT) imaging could discriminate between different diagnoses in HIV-infected patients presenting with lymphadenopathy, with or without fever and/or splenomegaly. Maximum standardised uptake (SUVmax) values were similar in lymphoma and mycobacterial and fungal infections and were lower but similar in those with human herpesvirus (HHV) 8-associated disease and HIV-associated reactive lymphadenopathy. Nodal 18FDG avidity, with SUVmax ≥10, excluded diagnoses of HHV 8-associated disease and miscellaneous conditions, and HIV-associated reactive lymphadenopathy was additionally excluded in those who had undetectable plasma HIV viral loads...
January 1, 2017: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29190937/18f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-as-a-screening-tool-for-second-primary-cancers-in-cancer-patients
#9
Yang Liu, Jie Ma, Yingxin Liu
Background: We performed a meta-analysis to evaluate the value of 18F-fluorodeoxyglucose positron emission tomography-computed tomography (18FDG PET-CT) for the detection of second primary cancers in cancer patients. Results: This present study analyzed a total of 6 selected studies (1374 patients). The sensitivity and specificity of PET-CT were 0.84 (95% confidence interval [CI] = 0.66 to 0.93), and 0.98 (95% CI = 0.97 to 0.98). Area under the curve was 0.98 (95% CI = 0...
November 3, 2017: Oncotarget
https://www.readbyqxmd.com/read/29175242/association-of-nonalcoholic-steatohepatitis-with-subclinical-myocardial-dysfunction-in-non-cirrhotic-patients
#10
Yong-Ho Lee, Kwang Joon Kim, Myung Eun Yoo, Gyuri Kim, Hye-Jin Yoon, Kwanhyeong Jo, Jong-Chan Youn, Mijin Yun, Jun Yong Park, Chi Young Shim, Byung-Wan Lee, Seok-Min Kang, Jong-Won Ha, Bong-Soo Cha, Eun Seok Kang
BACKGROUND & AIMS: Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular risk. Among categories of NAFLD, hepatic fibrosis is most likely to affect mortality. Myocardial function and its energy metabolism are tightly linked, which might be altered by an insulin resistant condition such as NAFLD. We investigated whether hepatic steatosis and fibrosis were associated with myocardial dysfunction relative to myocardial glucose uptake. METHODS: 308 patients (190 without NAFLD, 118 with NAFLD) were studied...
November 23, 2017: Journal of Hepatology
https://www.readbyqxmd.com/read/29138707/jejunojejunal-intussusception-due-to-metastatic-melanoma-seven-years-after-the-primer
#11
Alexander Giakoustidis, Thomas Goulopoulos, Anastasios Boutis, George Kavvadias, Aristidis Kainantidis, Thomas Zaraboukas, Dimitrios Giakoustidis
Intestinal intussusception in adults is a rare medical condition accounting for less than 5% of all intussusceptions. Herein we present a 45-year-old patient with a history of abdominal pain and loss of weight. CT scan revealed jejunojejunal intussusceptions. The patient was subjected to exploratory operation and small intestine resection due to a mass causing intestinal intussusception. Pathology confirmed suspected diagnosis of metastatic melanoma to small intestine secondary to melanoma, 7 years after the initial manifestation...
2017: Case Reports in Surgery
https://www.readbyqxmd.com/read/29115451/presence-of-the-minor-allele-of-microrna205-rs3842530-polymorphism-increases-18fdg-uptake-in-patients-with-breast-cancer-via-targeting-vegf
#12
Shiying Qu, Tie Wang, Jingwei Huang
MicroRNAs (miRNAs) are regarded as key regulators of gene expression involved in the pathogenesis of various diseases. Numerous single nucleotide polymorphisms (SNPs) in miRNA genes have been found to be associated with human diseases by affecting the processing process of miRNAs. In the present study, patients with breast cancer underwent a PET scan, and the maximum standard uptake value (SUVmax)/partial volume‑corrected standard uptake value (SUVpvc) were determined in each individual. The samples were collected and genotyped for rs3842530...
October 27, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29077855/increased-brain-glucose-uptake-after-12-weeks-of-aerobic-high-intensity-interval-training-in-young-and-older-adults
#13
Matthew M Robinson, Val J Lowe, K Sreekumaran Nair
Context: Aerobic exercise training can increase brain volume and blood flow, but the impact on brain metabolism is less known. Objective: We determined whether high-intensity interval training (HIIT) increases brain metabolism by measuring brain glucose uptake in younger and older adults. Design: Brain glucose uptake was measured before and after HIIT or a sedentary (SED) control period within a larger exercise study. Setting: Study procedures were performed at the Mayo Clinic in Rochester, MN...
January 1, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29046888/imaging-sex-differences-in-regional-brain-metabolism-during-acute-opioid-withdrawal
#14
Giovanni C Santoro, Joseph Carrion, Stephen L Dewey
The rate of opioid overdose continues to rise, necessitating improved treatment options. Current therapeutic approaches rely on administration of either a blocking agent, such as naloxone, or chronic treatment with replacement drugs, including methadone and/or buprenorphine. Recent findings suggest that males and females respond to these treatments uniquely. In an effort to better understand this sex-specific variation in treatment efficacy, we investigated the effects of acute opioid withdrawal in male and female rats using 18FDG and microPET...
April 2017: Journal of Alcoholism and Drug Dependence
https://www.readbyqxmd.com/read/29017830/suvmax-after-18-fluoro-deoxyglucose-positron-emission-tomography-computed-tomography-a-tool-to-define-treatment-strategies-in-pancreatic-cancer
#15
Ilaria Pergolini, Stefano Crippa, Matteo Salgarello, Giulio Belfiori, Stefano Partelli, Giacomo Ruffo, Alessandro Pucci, Giuseppe Zamboni, Massimo Falconi
BACKGROUND: (18)fluoro-deoxyglucose positron emission tomography/computed tomography (18FDG-PET/CT) might be a useful tool in the management of pancreatic ductal adenocarcinoma (PDAC). AIMS: The aim of this study was to analyze maximum standard uptake value (SUVmax) after 18FDG-PET/CT as predictor of survival outcomes and method to determine treatment strategies. METHODS: A consecutive series of patients who underwent preoperative 18FDG-PET/CT and subsequent resection for PDAC were retrospectively reviewed...
September 22, 2017: Digestive and Liver Disease
https://www.readbyqxmd.com/read/28959457/hemangioma-of-the-rib-showing-a-relatively-high-18f-fdg-uptake-a-case-report-with-a-literature-review
#16
Takahide Itabashi, Makoto Emori, Yoshinori Terashima, Tadashi Hasegawa, Junya Shimizu, Satoshi Nagoya, Toshihiko Yamashita
Hemangioma of the rib is a rare benign tumor that is often difficult to distinguish from malignant bone tumors. Rib hemangioma often shows bony disruption with a slight cortical disruption, extraosseous lesion, and expanded bone on computed tomography (CT). We report the case of a 68-year-old man with atypical rib hemangioma with a slight cortical disruption and no expanded bone. The tumor showed relatively high 18FDG-uptake on positron emission tomography (PET)/CT. Rib hemangioma often shows higher 18FDG-uptake...
September 2017: Acta Radiologica Open
https://www.readbyqxmd.com/read/28951388/retinal-microperimetry-a-new-tool-for-identifying-type-2-diabetic-patients-at-risk-of-developing-alzheimer%C3%A2-s-disease
#17
Andreea Ciudin, Olga Simó-Servat, Cristina Hernández, Gabriel Arcos, Susana Diego, Ángela Sanabria, Óscar Sotolongo, Isabel Hernández, Mercè Boada, Rafael Simó
Type 2 diabetes is associated with a high risk of cognitive impairment and dementia. Therefore, strategies aimed at identifying those patients at risk of dementia are needed. Given that the retina is a brain-derived tissue it may provide a non-invasive way of examining brain pathology. The aims of the study were to evaluate whether retinal sensitivity: 1) Correlates with the specific parameters of brain imaging related to cognitive impairment; 2) Discriminates diabetic patients with mild cognitive impairment (MCI) from those with normal cognition and Alzheimer's disease (AD)...
September 26, 2017: Diabetes
https://www.readbyqxmd.com/read/28930979/analysis-of-18fdg-pet-ct-imaging-as-a-tool-for-studying-mycobacterium-tuberculosis-infection-and-treatment-in-non-human-primates
#18
Alexander G White, Pauline Maiello, M Teresa Coleman, Jaime A Tomko, L James Frye, Charles A Scanga, Philana Ling Lin, JoAnne L Flynn
Mycobacterium tuberculosis remains the number one infectious agent in the world today. With the emergence of antibiotic resistant strains, new clinically relevant methods are needed that evaluate the disease process and screen for potential antibiotic and vaccine treatments. Positron Emission Tomography/Computed Tomography (PET/CT) has been established as a valuable tool for studying a number of afflictions such as cancer, Alzheimer's disease, and inflammation/infection. Outlined here are a number of strategies that have been employed to evaluate PET/CT images in cynomolgus macaques that are infected intrabronchially with low doses of M...
September 5, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28830293/the-narlal2-dose-escalation-trial-dosimetric-implications-of-inter-fractional-changes-in-organs-at-risk
#19
Lone Hoffmann, Marianne Marquard Knap, Azza Ahmed Khalil, Christina Maria Lutz, Ditte Sloth Møller
BACKGROUND: Phase II trials suggested that survival rates for locally advanced lung cancer could be increased by radiotherapy dose escalation. However, results of the phase III RTOG 0617 trial illustrated an imminent risk of treatment-related death. This could be thwarted with strict constraints to organs at risk (OARs) and control of the delivered dose. This study investigates the impact of anatomical changes during radiotherapy on escalated dose distributions used in the Danish NARLAL2 dose escalation trial...
August 23, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28803235/18f-fdg-uptake-in-well-differentiated-neuroendocrine-tumors-correlates-with-both-ki-67-and-vhl-pathway-inactivation
#20
Margot Bucau, Astrid Laurent-Bellue, Nicolas Poté, Olivia Hentic, Jérôme Cros, Nidaa Mikail, Vinciane Rebours, Philippe Ruszniewski, Rachida Lebtahi, Anne Couvelard
<br>Introduction: 18FDG PET-scanner positivity correlates with poor prognosis in neuroendocrine neoplasms (NEN). Glucose transporter 1 (GLUT1) and carbonic anhydrase 9 (CA9) are markers of agressivity in tumors. Together with pVHL, they are involved in tumor cell metabolism via the hypoxia-inducible factor (HIF) signaling pathway. The aim of this study was to compare, in a series of well-differentiated neuroendocrine tumors (NET), the 18-FDG uptake and expression of proliferation marker Ki-67, GLUT-1, CA9 and pVHL...
August 11, 2017: Neuroendocrinology
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