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18FDG

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https://www.readbyqxmd.com/read/29760045/gfpt2-expressing-cancer-associated-fibroblasts-mediate-metabolic-reprogramming-in-human-lung-adenocarcinoma
#1
Weiruo Zhang, Gina Bouchard, Alice Yu, Majid Shafiq, Mehran Jamali, Joseph B Shrager, Kelsey Ayers, Shaimaa Bakr, Andrew J Gentles, Maximilian Diehn, Andrew Quon, Robert B West, Viswam Nair, Matt van de Rijn, Sandy Napel, Sylvia K Plevritis
Metabolic reprogramming of the tumor microenvironment is recognized as a cancer hallmark. To identify new molecular processes associated with tumor metabolism, we analyzed the transcriptome of bulk and flow-sorted human primary non-small cell lung cancer (NSCLC) together with 18FDG-positron emission tomography scans, which provide a clinical measure of glucose uptake. Tumors with higher glucose uptake were functionally enriched for molecular processes associated with invasion in adenocarcinoma (AD) and cell growth in squamous cell carcinoma (SCC)...
May 14, 2018: Cancer Research
https://www.readbyqxmd.com/read/29736179/natural-compound-methyl-protodioscin-suppresses-proliferation-and-inhibits-glycolysis-in-pancreatic-cancer
#2
LianYu Chen, Chien-Shan Cheng, HuiFeng Gao, Ling Zhan, FengJiao Wang, Chao Qu, Ye Li, Peng Wang, Hao Chen, ZhiQiang Meng, LuMing Liu, HaiFeng Chen, Zhen Chen
Methyl protodioscin (MPD) is one of the main bioactive components in the plant of Dioscoreaceae. MPD has been demonstrated to possess antitumor activities. However, its role in pancreatic cancer and the underlying molecular mechanisms are poorly defined. In the present study, we demonstrated that MPD inhibited proliferation and promoted apoptosis of pancreatic cancer. Furthermore, our results demonstrated that MPD decreased oncogene c-Myc in protein level and resulted in concomitant reduction in glycolysis...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29725842/motor-neuron-disease-of-paraneoplastic-origin-a-rare-but-treatable-condition
#3
Nicolas Mélé, Giulia Berzero, Thierry Maisonobe, François Salachas, Guillaume Nicolas, Nicolas Weiss, Guillemette Beaudonnet, Francois Ducray, Dimitri Psimaras, Timothée Lenglet
Paraneoplastic motor neuron disorders (MND) are rare conditions; their exact clinical and electrophysiological phenotype have not been exhaustively described yet. The purpose of this study is to depict the main characteristics of paraneoplastic MND to highlight the features that may allow its diagnosis. Based on the description of eight original cases, and on the revision of 21 patients identified from a systematic review of the literature, the main features of paraneoplastic MND can be summarized as follows: (1) subacute; (2) lower motor neuron syndrome, associated or not with upper motor neuron involvement; (3) predominant asymmetric upper limb involvement; (4) presence of other non-motor neurological manifestations, including sensory neuronopathy; (5) signs of inflammation in the cerebrospinal fluid (CSF); (6) neurological improvement or stabilization after immunotherapy and tumor treatment...
May 3, 2018: Journal of Neurology
https://www.readbyqxmd.com/read/29720487/metabolic-heterogeneity-on-baseline-18fdg-pet-ct-scan-is-a-predictor-of-outcome-in-primary-mediastinal-b-cell-lymphoma
#4
Luca Ceriani, Lisa Milan, Maurizio Martelli, Andrés J M Ferreri, Luciano Cascione, Pier Luigi Zinzani, Alice Di Rocco, Annarita Conconi, Anastasios Stathis, Franco Cavalli, Monica Bellei, Kelly Cozens, Elena Porro, Luca Giovanella, Peter W Johnson, Emanuele Zucca
An important unmet need in the management of primary mediastinal B-cell lymphoma (PMBCL) is to identify the patients for whom first line therapy will fail, in order to intervene before the lymphoma becomes refractory. High heterogeneity of intratumoral 18F-fluorodeoxyglucose (18FDG) uptake distribution on positron emission tomography/computed tomography (PET/CT) scans has been suggested as a possible marker of chemo-resistance in solid tumors. In the present study, we investigated the prognostic value of metabolic heterogeneity (MH) in 103 PMBCL patients prospectively enrolled in the International Extranodal Lymphoma Study Group (IELSG) 26 study, aimed at clarifying the role of PET in this lymphoma subtype...
May 2, 2018: Blood
https://www.readbyqxmd.com/read/29705152/evaluation-of-diffuse-large-b-cell-lymphoma-patients-with-64-slice-multidetector-computed-tomography-versus-18-fdg-positron-emission-tomography-computed-tomography-in-initial-staging-and-restaging-after-treatment
#5
Nieves Gómez León, Gema Vega, Beatriz Rodríguez-Vigil Junco, Carlos Suevos Ballesteros
BACKGROUND AND OBJECTIVES: To prospectively compare the accuracy in initial staging and end-of-treatment restaging of diffuse large B-cell lymphoma (DLBCL) between 64-slice multidetector computed tomography (64MDCT) and 18FDG positron emission tomography/computed tomography (18FGD PET/CT) with intravenous contrast injection. MATERIAL AND METHODS: Randomised and blind controlled clinical multicentric trial that included biopsy-proven DLBCL patients. Seventy-two patients from five different hospitals in the region of Madrid, Spain, were enrolled in the study between January 2012 and June 2015...
April 25, 2018: Medicina Clínica
https://www.readbyqxmd.com/read/29644487/therapeutic-use-of-carbohydrate-restricted-diets-in-an-autistic-child-a-case-report-of-clinical-and-18fdg-pet-findings
#6
Iwona Żarnowska, Beata Chrapko, Grażyna Gwizda, Anna Nocuń, Krystyna Mitosek-Szewczyk, Maciej Gasior
The ketogenic diet (KD) is a high-fat, adequate-protein, and low-carbohydrate diet that has been used successfully in the treatment of refractory epilepsies for almost 100 years. There has been accumulating evidence to show that the KD may provide a therapeutic benefit in autism spectrum disorders, albeit by a yet-unknown mechanism. We report a case of a 6-year-old patient with high-functioning autism and subclinical epileptic discharges who responded poorly to several behavioural and psychopharmacological treatments...
April 11, 2018: Metabolic Brain Disease
https://www.readbyqxmd.com/read/29618578/pet-response-assessment-in-apatinib-treated-radioactive-iodine-refractory-thyroid-cancer
#7
Chen Wang, Xin Zhang, Xue Yang, Hui Li, Ruixue Cui, Wenmin Guan, Xin Li, Zhaohui Zhu, Yansong Lin
This work evaluated the use of the positron emission tomography/computed tomography (PET/CT) technique to assess the early therapeutic response and predict the prognosis of patients with radioactive iodine-refractory differentiated thyroid cancer (RAIR-DTC) who underwent apatinib therapy. Standardised uptake value (SUV), metabolic tumour volume (MTV) and total lesion glycolysis (TLG), derived from 18FDG PET/CT and SUV from 68Ga-NOTA-PRGD2 PET/CT, were evaluated. Tumour response was evaluated using the Response Evaluation Criteria in Solid Tumors (RECIST) 1...
April 4, 2018: Endocrine-related Cancer
https://www.readbyqxmd.com/read/29523196/2-deoxy-2-18-fluoro-d-glucose-pet-ct-18fdg-pet-ct-may-not-be-a-viable-biomarker-in-pompe-disease
#8
U Plöckinger, V Prasad, A Ziagaki, N Tiling, A Poellinger
BACKGROUND: Pompe disease (PD) is an autosomal recessive, lysosomal storage disease due to a mutation of the acid α-glucosidase (GAA) gene. In adult patients, PD is characterized by slowly progressive limb-girdle and trunk myopathy and restrictive respiratory insufficiency. Enzyme replacement therapy (ERT) is available, improving or stabilizing muscle-function in some and slowing deterioration in other patients. Unfortunately, there is no biomarker available to indicate therapeutic efficacy and/or disease activity...
March 9, 2018: Human Genomics
https://www.readbyqxmd.com/read/29507854/primary-intramedullary-malignant-lymphoma-in-the-cervical-cord-with-a-presyrinx-state
#9
Kohei Chida, Atsushi Sugawara, Takahiro Koji, Takaaki Beppu, Yoshiharu Mue, Tamotsu Sugai, Knuaki Ogasawara
A 79-year-old man presented with primary intramedullary malignant lymphoma with a presyrinx state in the cervical cord manifesting as left hemiparesis and hemidysesthesia. The magnetic resonance imaging (MRI) scan showed an intramedullary mass in the cervical spinal cord at the level of C1 and T2-weighted image prolongation from the medulla to the level of C5. According to the progression of hemiparesis, he underwent an emergency removal of the tumor under general anesthesia. The tumor was totally removed, and the peritumoral signal abnormality was not present in the postoperative MRI...
December 30, 2017: Curēus
https://www.readbyqxmd.com/read/29465347/an-increased-major-vessel-uptake-by-18f-fdg-pet-ct-in-nih-criteria-clinical-inactive-patients-with-takayasu-s-arteritis
#10
Qing Han, Qiang Liang, Fei Kang, Jing Wang, Zhenbiao Wu, Ping Zhu
OBJECTIVES: The commonly adopted method of defining active disease in Takayasu's arteritis (TAK) is the definition used by the US National Institutes of Health (NIH). A gold standard in imaging techniques for assessing disease activity in TAK has not been clearly established and the creation of practical and valid tools represents a challenge. To assess whether 18F-FDG-PET/CT and NIH criteria show a good level of agreement in assessing disease activity of TAK patients. METHODS: 18F-FDG-PET/CT was performed in 17 patients with TAK...
February 7, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29435284/-18-f-fluoro-2-deoxyglucose-positron-emission-computed-tomography-in-a-rare-cutaneous-form-of-rosai-dorfman-disease-a-case-report
#11
Joya Hadchiti, Francois G Kamar, Jean Abi Ghosn, Mohamad Haidar, Ahmad Younes, Antoine Obeid, Marwan Haddad, Fadi Farhat, Feras Chehade
Rosai-Dorfman disease (RDD), or sinus histiocytosis with massive lymphadenopathy, commonly involves the lymph nodes but may secondarily involve the skin. Purely cutaneous disease without lymphatics or internal organ involvement occurs rarely. The present report detailed a rare case of 18 F-fluoro-2-deoxyglucose positron emission-computed tomography (18 FDG PET-CT) performed in a 33-year-old male soldier with a purely cutaneous form of RDD. Staging with 18 FDG PET-CT was ordered prior to excisional biopsies of the aforedescribed masses and pathology reported RDD...
February 2018: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29377508/clinical-value-of-18-fdg-pet-ct-in-screening-for-distant-metastases-in-head-and-neck-squamous-cell-carcinoma
#12
S E Deurvorst, O S Hoekstra, J A Castelijns, B I Witte, C R Leemans, R de Bree
OBJECTIVES: The detection of distant metastases is of major importance in management of head and neck squamous cell carcinoma patients. DESIGN: All patients underwent 18 FDG PET/CT for the detection of distant metastases. SETTING: Retrospective single-centre study. PARTICIPANTS: Head and neck squamous cell carcinoma patients with high-risk factors for distant metastases. MAIN OUTCOME MEASURES: Accuracy of 18 FDG PET/CT for the detection of distant metastases using clinical development of distant metastases and a minimal follow-up of twelve months as reference standard...
January 28, 2018: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29365058/colorectal-cancer-crc-monitoring-by-six-monthly-18fdg-pet-ct-an-open-label-multicentre-randomised-trial
#13
I Sobhani, E Itti, A Luciani, I Baumgaertner, R Layese, T André, M Ducreux, J-M Gornet, G Goujon, T Aparicio, J Taieb, J-B Bachet, F Hemery, A Retbi, M Mons, R Flicoteaux, B Rhein, S Baron, I Cherrak, P Rufat, P Le Corvoisier, N De'Angelis, P-A Natella, H Maoulida, C Tournigand, I Durand Zaleski, S Bastuji-Garin
Background: 18FDG-PET/CT has high sensitivity for detecting recurrences of colorectal cancer (CRC). Our objective was to determine whether adding routine 6-monthly 18FDG-PET/CT to our usual monitoring strategy improved patient outcomes and to assess the effect on costs. Patients and Methods: In this open-label multicentre trial, patients in remission of CRC (stage II perforated, stage III, or stage IV) after curative surgery were randomly assigned (1:1) to usual monitoring alone (3-monthly physical and tumour marker assays, 6-monthly liver ultrasound and chest radiograph, and 6-monthly whole-body computed tomography) or with 6-monthly 18FDG-PET/CT, for 3 years...
January 22, 2018: Annals of Oncology: Official Journal of the European Society for Medical Oncology
https://www.readbyqxmd.com/read/29352608/differences-in-lung-injury-after-imrt-or-proton-therapy-assessed-by-18-fdg-pet-imaging
#14
Nadya Shusharina, Zhongxing Liao, Radhe Mohan, Amy Liu, Andrzej Niemierko, Noah Choi, Thomas Bortfeld
BACKGROUND AND PURPOSE: To compare lung injury among non-small cell lung cancer (NSCLC) patients treated with IMRT or proton therapy as revealed by 18 F-FDG post-treatment uptake and to determine factors predictive for clinically symptomatic radiation pneumonitis. MATERIAL AND METHODS: For 83 patients treated with IMRT or proton therapy, planning CT and follow up 18 F-FDG PET-CT were analyzed. Post-treatment PET-CT was aligned with planning CT to establish a voxel-to-voxel correspondence between PET and planning dose images...
January 15, 2018: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/29338617/carbon-nanospheres-mediated-nuclear-delivery-of-smar1-protein-dna-binding-domain-controls-breast-tumor-in-mice-model
#15
Prasad N Bhagat, Sachin H Jadhav, Samit Chattopadhyay, Kishore M Paknikar
AIM: To investigate anticancer activity of the DNA binding domain of SMAR1 (His 5) in vitro and in vivo. MATERIALS & METHODS: His 5 was conjugated to hydrothermally synthesized carbon nanospheres (CNs). Anticancer activity of CNs-His 5 was evaluated in vitro and in vivo. RESULTS: CNs- His 5 significantly reduced cyclin D1 levels in MDA-MB-231 cells. Tumor bearing Balb/c mice injected with CNs-His 5 showed approximately 62% tumor regression and significantly reduced 18 FDG uptake...
February 2018: Nanomedicine
https://www.readbyqxmd.com/read/29325553/sitagliptin-improved-glucose-assimilation-in-detriment-of-fatty-acid-utilization-in-experimental-type-ii-diabetes-role-of-glp-1-isoforms-in-glut4-receptor-trafficking
#16
E Ramírez, B Picatoste, A González-Bris, M Oteo, F Cruz, A Caro-Vadillo, J Egido, J Tuñón, M A Morcillo, Ó Lorenzo
BACKGROUND: The distribution of glucose and fatty-acid transporters in the heart is crucial for energy consecution and myocardial function. In this sense, the glucagon-like peptide-1 (GLP-1) enhancer, sitagliptin, improves glucose homeostasis but it could also trigger direct cardioprotective actions, including regulation of energy substrate utilization. METHODS: Type-II diabetic GK (Goto-Kakizaki), sitagliptin-treated GK (10 mg/kg/day) and wistar rats (n = 10, each) underwent echocardiographic evaluation, and positron emission tomography scanning for [18 F]-2-fluoro-2-deoxy-D-glucose (18 FDG)...
January 11, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29287785/evaluation-of-muscle-activity-just-after-straight-leg-raising-exercise-by-using-18-fdg-pet
#17
Hiroyuki Shiozawa, Takashi Ohsawa, Yoshito Tsushima, Tetsuya Higuchi, Kenji Takagishi, Hirotaka Chikuda
BACKGROUND: Exercise therapy is one of the recognized treatment methods for knee osteoarthritis (KOA). One such exercise technique, straight leg raising (SLR), is widely known as a home exercise method for strengthening the quadriceps femoris muscle. However, whether this exercise truly strengthens the quadriceps is not known. The objective of the present study was to investigate which lower limb muscle is stimulated and shows increased activity with SLR. METHODS: A total of 14 lower limbs in seven healthy adult male volunteers (mean age: 31...
March 2018: Journal of Orthopaedic Science: Official Journal of the Japanese Orthopaedic Association
https://www.readbyqxmd.com/read/29273076/highly-conformal-combined-radiotherapy-with-cisplatin-and-gemcitabine-for-treatment-of-loco-regionally-advanced-cervical-cancer-a-retrospective-study
#18
Nikola Cihoric, Alexandros Tsikkinis, Eugenia Vlaskou Badra, Markus Glatzer, Urban Novak, Amina Scherz, Mohamed Shelan, Ivan Soldatovic, Chittazhathu Kurian Kuruvilla Yojena, Daniel M Aebersold, Kristina Lössl
BACKGROUND: Cisplatin and gemcitabine combined with conventional radiation therapy in the treatment of cervical cancer patients results in a favorable outcome but with excess toxicity. The purpose of this study was to evaluate the toxicity profile of dual chemotherapy and highly conformal external beam radiotherapy with image guided adaptive brachytherapy. METHODS: Seventeen patients with cervical carcinoma FIGO stage IB2-IIIB were treated with curative intent between 2011 and 2015...
December 22, 2017: Radiation Oncology
https://www.readbyqxmd.com/read/29261622/18fdg-pet-ct-for-the-visualization-of-inflammatory-component-of-radiation-induced-lung-injury-after-stereotactic-radiotherapy
#19
Olarn Roengvoraphoj, Montserrat Pazos-Escudero, Chukwuka Eze, Maurice Dantes, Farkhad Manapov
Visualization and metabolic analysis of acute inflammation in the lung parenchyma plays a crucial role for the prediction and diagnosis of radiation-induced lung injury and is particularly important in medically inoperable patients because of a priori very limited pulmonary function. This case confirms that a radiation-induced lung injury is accompanied by acute inflammatory reaction in the lung parenchyma irradiated with a total dose of 12-40 Gy. This well-defined inflammation component could be exactly characterized with FDG-PET/CT...
March 2018: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/29231148/pet-radiopharmaceuticals-in-brazil-and-belarus-economic-comparison-using-the-case-of-18fdg
#20
Sviatoslav Brinkevich, Leonardo Paredes Pires, Filipe Leal Portilho, Ralph Santos-Oliveira
The production of radiopharmaceuticals, especially the PET ones, is a complex combination of economic and social factors. Despite the social aspects, that are essential, the economic issue must be considered and play an important parameter for the implementation and maintenance of producer centers around the world, with especial regards for countries which face economic crisis and/or belongs to aegis of under development countries. In order to evaluate this scenario with carried out this study, comparing a well-established producer center in Brazil and a new on in Belarus...
December 11, 2017: Current Radiopharmaceuticals
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