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Angela Botticella, Gilles Defraene, Kristiaan Nackaerts, Christophe M Deroose, Johan Coolen, Philippe Nafteux, Stephanie Peeters, Umberto Ricardi, Dirk De Ruysscher
BACKGROUND: The gross tumor volume (GTV) definition for malignant pleural mesothelioma (MPM) is ill-defined. We therefore investigated which imaging modality is optimal: computed tomography (CT) with intravenous contrast (IVC), positron emission tomography-CT (PET/CT) or magnetic resonance imaging (MRI). MATERIAL AND METHODS: Sixteen consecutive patients with untreated stage I-IV MPM were included. Patients with prior pleurodesis were excluded. CT with IVC, 18FDG-PET/CT and MRI (T2 and contrast-enhanced T1) were obtained...
October 12, 2016: Acta Oncologica
Naomi E Verstegen, Alexander P W M Maat, Frank J Lagerwaard, Marinus A Paul, Michel I Versteegh, Joris J Joosten, Willem Lastdrager, Egbert F Smit, Ben J Slotman, Joost J M E Nuyttens, Suresh Senan
INTRODUCTION: The literature on surgical salvage, i.e. lung resections in patients who develop a local recurrence following stereotactic ablative radiotherapy (SABR), is limited. We describe our experience with salvage surgery in nine patients who developed a local recurrence following SABR for early stage non-small cell lung cancer (NSCLC). METHODS: Patients who underwent surgical salvage for a local recurrence following SABR for NSCLC were identified from two Dutch institutional databases...
October 3, 2016: Radiation Oncology
Anna Kocurek, Bogdan Małkowski, Agnieszka Giza, Wojciech Jurczak
AIM OF THE STUDY: Determining the role of PET/CT imaging in the evaluation of treatment efficacy in primary mediastinal B-cell lymphoma (PMBCL). MATERIAL AND METHODS: Retrospective analysis of seven PMBCL patients, treated at the University Hospital in Krakow, with interim PET/CT after the third course of chemo-immunotherapy.The analysis was based on the calculation of exact tumour volume and metabolic activity, compared with initial values (directly after diagnosis)...
2016: Contemporary Oncology Współczesna Onkologia
Maud Pichon, Nidaa Mikail, Khadija Ben Ali, François Rouzet, Charles Burdet, Yazdan Yazdanpanah, Veronique Joly, Laurent Lepage, Laure Sarda-Mantel
No abstract text is available yet for this article.
September 12, 2016: Infectious Diseases
David Val-Laillet, Paul Meurice, Caroline Clouard
Brain responses to feed flavors with or without a feed additive (FA) were investigated in piglets familiarized or not with this FA. Sixteen piglets were allocated to 2 dietary treatments from weaning until d 37: the naive group (NAI) received a standard control feed and the familiarized group (FAM) received the same feed added with a FA mainly made of orange extracts. Animals were subjected to a feed transition at d 16 post-weaning, and to 2-choice feeding tests at d 16 and d 23. Production traits of the piglets were assessed up to d 28 post-weaning...
2016: PloS One
Melissa Ochoa, Charles-Henri Malbert, Paul Meurice, David Val-Laillet
Excessive sugar intake might increase the risk to develop eating disorders via an altered reward circuitry, but it remains unknown whether different sugar sources induce different neural effects and whether these effects are dependent from body weight. Therefore, we compared the effects of three high-fat and isocaloric diets varying only in their carbohydrate sources on brain activity of reward-related regions, and assessed whether brain activity is dependent on insulin sensitivity. Twenty-four minipigs underwent 18FDG PET brain imaging following 7-month intake of high-fat diets of which 20% in dry matter weight (36...
2016: PloS One
Raphael Lhote, Julien Haroche, Loïc Duron, Nicolas Girard, Marie Pierre Lafourcade, Michel Martin, Hugues Begueret, André Taytard, Frédérique Capron, Philippe Grenier, Jean Charles Piette, Fleur Cohen-Aubart, Zahir Amoura
Pulmonary hyalinizing granuloma (PHG) is a rare disease characterized by single or multiple benign lung nodules mimicking lung neoplasma. Histologic analysis reveals homogenous hyaline lamellae, usually surrounded by collection of plasma cells, lymphocytes and histiocytes in a perivascular distribution. The clinical and radiological findings have been described in small series, but the long-term outcomes have rarely been reported. The objectives were to describe the clinical, radiological and outcomes of PHG in new cases and through a literature review...
August 25, 2016: Immunologic Research
Maseeh Uz Zaman, Nosheen Fatima, Areeba Zaman, Unaiza Zaman, Rabia Tahseen
BACKGROUND: Fluorodeoxyglucose (18FDG) PET/CT imaging has become an important component of the management paradigm in oncology. However, the significant imparted radiation exposure is a matter of growing concern especially in younger populations who have better odds of survival. The aim of this study was to estimate the effective dose received by patients having whole body 18FFDG PET/CT scanning as per recent dose reducing guidelines at a tertiary care hospital. MATERIALS AND METHODS: This prospective study covered 63 patients with different cancers who were referred for PET/CT study for various indications...
2016: Asian Pacific Journal of Cancer Prevention: APJCP
Sushil K Sharma
Recent advances in the self-shielded cyclotrons, improved targets, video-monitored hot cells design, and automated PET radiopharmaceutical (RPs) synthesis modules, utilizing computer-controlled graphic user interphase (GUI) has revolutionized PET molecular imaging technology for basic biomedical research and theranostics to accomplish the ultimate goal of evidence-based personalized medicine. Particularly, [18F]HX4: (3-[18F]fluoro-2-(4-((2-nitro-1Himidazol-1-yl)methyl)-1H-1,2,3,-triazol-1-yl)-propan-1-ol), 18F-FAZA: 1-(5-[18F]Fluoro-5-deoxy-α-D-arabinofuranosyl)-2-nitroimidazole, and 18F-FMSIO: 18F-Ffluoromisonidazole to assess tumor hypoxia, [18F]FB-VAD-FMK: [18F]4-fluorobenzylcarbonyl-Val-Ala-Asp(OMe)-fluoromethylketone to determine in vivo apoptosis, 64Cu-PTSM: 64Cu-Pyrualdehyde Bis-N-Methylthiosemicarbazone for brain and myocardial perfusion imaging, and 68Ga-DOTATOC: 68Ga-DOTAD-Phy1-Tyr3-octreotide and 68Ga-DOTANOC: 68Ga-(1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid)-1-NaI3-octreotide for neuroendocrine and neural crest tumors have demonstrated great promise in personalized theranostics...
July 19, 2016: Current Drug Targets
Qingguo Li, Yi Qin, Ping Wei, Peng Lian, Yaqi Li, Ye Xu, Xinxiang Li, Dawei Li, Sanjun Cai
UNLABELLED: Growth arrest-specific 1 (Gas1) plays a critical role in growth suppression. Previous study indicated that Gas1 was closely associated with survival in patients with colorectal cancer; however, the underlying molecular mechanism remains unclear. In this study, we sought to determine the role of Gas1 in tumorigenesis and metastasis, and elucidate the possible mechanism. First, Gas1 was determined as a negative regulator of oncogenesis and metastasis in colorectal cancer. Mechanistically, Gas1 negatively regulated the aerobic glycolysis, a process that contributed to tumor progression and metastasis by providing energy source and building blocks for macromolecule synthesis...
September 2016: Molecular Cancer Research: MCR
Diane Mege, Serge Cammilleri, Olivier Mundler, Françoise Dignat-George, Christophe Dubois, Laurence Panicot-Dubois, Sandrine Guis
Polymyalgia rheumatica (PMR), a chronic inflammatory rheumatism, can be the expression of a paraneoplastic syndrome. The same clinical symptoms are frequently observed at the early stage of the benign and malignant forms. Here, our aim was to develop diagnostic tools to differentiate paraneoplastic PMR from essential PMR. We combined an 18FDG-PET and detection of circulating procoagulant microparticles (MPs), such as fibrin positive (FibMPs), by flow cytometry. Two patients with PMR and a similar profile were selected...
August 2016: Rheumatology International
Guensi Amal, Taleb Sara, Cherkaoui Salhi Ghofrane, Ait Idir Malika, Houjami Majdouline, Sahraoui Souha, Benider Abdelatif, Touil Najoua, Benmoussa Ghita, Baroudi Zineb, Chikhaoui Nabil
Merkel cell carcinoma (MCC) is a rare neuroendocrine carcinoma of the skin with unpredictable evolution and high metastatic potential. This neoplasm usually occurs in the elderly on their sun-exposed areas. CCM constant greed for 18 fluorodeoxyglucose (FDG) defines the role of positron emission tomography (PET) in this pathology. However, no consensus has yet been reached. This study reports the case of a 25 year old woman treated for metastatic MCC, in order to draw attention to this particular tumor and to illustrate the role of 18 FDG PET in the management of this rare entity...
2016: Pan African Medical Journal
Olivier Caubet, Vincent Meunier, Roger Marthan, Eric Laffon
PURPOSE: To describe a procedure allowing early assessment of treatment response in Takayasu arteritis (TA) patients by averaging the standard uptake value obtained from N hottest voxels irrespective of their location within the F-FDG-positive vessel walls (SUVmax-N). METHODS: The procedure is illustrated in a score-V TA patient before and after 1 and 3 months of glucocorticoid treatment (scans 0-1-3, respectively). Comparison between scans was made by using SUVmax-N repeatability percentages with 95-99-99...
September 2016: Clinical Nuclear Medicine
Paolo Zanotti-Fregonara, Mathieu Chastan, Agathe Edet-Sanson, Ozgul Ekmekcioglu, Ezgi Basak Erdogan, Sebastien Hapdey, Elif Hindie, Michael G Stabin
: Data from the literature show that the fetal absorbed dose from (18)F-FDG administration to the pregnant mother ranges from 0.5E-2 to 4E-2 mGy/MBq. These figures were however obtained using different quantification techniques and with basic geometric anthropomorphic phantoms. The aim of this study was to standardize the fetal doses of published as well as new cases and to refine the dose using realistic voxel-based phantoms. METHODS: The FDG doses to the fetus (n = 19; 5 to 34 weeks of pregnancy) were calculated with new voxel-based anthropomorphic phantoms of the pregnant woman...
June 3, 2016: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
A Durmus, A Yilmaz, F Malya, G Ozturk, H Bektasoglu, G Ertugrul, S Karyagar, O Karatepe
The aim of this study is to evaluate the effect of 18FDG PET on preoperative staging and clinical management of pancreatic cancer. Between December 2011 and February 2015, 28 consecutive patients with borderline resectable pancreatic cancer were evaluated with both 18FDG PET scans and conventional preoperative imaging studies. Medical records of all patients were noted prospectively. 18FDG PET findings were compared with conventional imaging studies and over-staging or down-staging rates with changes in clinical management were evaluated...
April 2016: Georgian Medical News
Deep Dutta, Meha Sharma, Vrushali Mahajan, Prem Chopra
Metastasis to spleen is rare and usually occurs in the setting of extensive multivisceral metastatic disease. A 60-year-old lady with appropriately managed early breast cancer (breast conservative surgery for Grade-2 infiltrative ductal carcinoma [0.7 cm × 0.5 cm diameter]) in 2006, was detected to have splenic incidentaloma (1.4 cm × 0.8 cm) in November 2012, which was fluoro-deoxy-glucose (FDG) avid on positron emission tomography. Fine needle spiration cytology (FNAC) was normal. More than doubling of lesion size by March 2015 (3...
April 2016: Indian Journal of Pathology & Microbiology
Sylvain Pilorge, Stephanie Harel, Vincent Ribrag, Frédérique Larousserie, Lise Willems, Patricia Franchi, Marielle Legoff, David Biau, Philippe Anract, Christian Roux, Estelle Blanc-Autran, Richard Delarue, Christian Gisselbrecht, Nicolas Ketterer, Christian Recher, Christophe Bonnet, Frederic Peyrade, Corinne Haioun, Hervé Tilly, Gilles Salles, Pauline Brice, Didier Bouscary, Bénédicte Deau, Jerome Tamburini
Primary bone diffuse large B-cell lymphoma (PB-DLBCL) is a rare DLBCL location variant. We treated 76 PB-DLBCL patients by immuno-chemotherapy, resulting in an 84% sustained complete remission rate and a 78.9% survival over a 4.7-year median follow-up period. Ann Arbor stage IV and high age-adjusted international prognostic index were predictive of adverse outcome in univariate analysis. In multivariate analysis using a Cox model, only aa-IPI predicted long-term survival. While based on a limited number of cases, we suggested that radiotherapy may be useful as a consolidation modality in PB-DLBCL...
April 27, 2016: Leukemia & Lymphoma
Aurore Goineau, Stéphane Supiot
No abstract text is available yet for this article.
September 2016: Clinical Nuclear Medicine
Kjell Öberg, Anders Sundin
Neuroendocrine tumors (NETs) comprise a heterogeneous group of malignancies with a very variable clinical expression and progression. They present unique properties that are important to consider for radiological and nuclear imaging, such as APUD-characteristics (amine precursor uptake and dearboxylation), as well as the expression of somatostatin receptors. The most common localizations are the lungs, gastrointestinal tract and pancreas. The only curative treatment is surgery, but more than 50% present metastatic disease at the time of diagnosis...
2016: Frontiers of Hormone Research
Georg Bier, Vera Hoffmann, Christopher Kloth, Ahmed E Othman, Thomas Eigentler, Claus Garbe, Christian La Fougère, Christina Pfannenberg, Konstantin Nikolaou, Bernhard Klumpp
Rationale of this study was the evaluation of the diagnostic value of computed tomography (CT) in the detection of bone marrow infiltration in comparison to PET/CT. Fifty patients (age 61 ± 15.12 years) with metastatic malignant melanoma underwent 18F-FDG-PET/CT, including contrast-enhanced CT. 2 readers evaluated the CT images in consensus for bone and bone marrow lesions focusing on lesion location, type and size. PET/CT was used as reference standard to estimate sensitivity, specificity, negative and positive predictive value...
April 2016: European Journal of Radiology
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