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Liver, gastroenterology, pediatrics

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https://www.readbyqxmd.com/read/28837442/diagnosis-follow-up-and-treatment-of-cystic-fibrosis-related-liver-disease
#1
Ivo P van de Peppel, Anna Bertolini, Johan W Jonker, Frank A J A Bodewes, Henkjan J Verkade
PURPOSE OF REVIEW: To provide an insight and overview of the challenges in the diagnosis, follow-up and treatment of cystic fibrosis-related liver disease (CFLD). RECENT FINDINGS: The variable pathophysiology of CFLD complicates its diagnosis and treatment. A 'gold standard' for CFLD diagnosis is lacking. Over the past years, new techniques to diagnose features of CFLD, such as transient elastography, have been investigated. Although most of these tests confirm cystic fibrosis-related liver involvement (CFLI), they are, however, not suitable to distinguish various phenotypical presentations or predict progression to clinically relevant cirrhosis or portal hypertension...
August 23, 2017: Current Opinion in Pulmonary Medicine
https://www.readbyqxmd.com/read/28588171/clinical-and-laboratory-predictors-of-esophageal-varices-in-children-with-chronic-liver-disease
#2
M I Hasan, M Rukunuzzaman, M Nurullah, F Sultana
Esophageal varices are a serious consequence of portal hypertension in patients with chronic liver diseases. Several studies have evaluated possible noninvasive markers of esophageal varices to reduce the number of unnecessary endoscopies in patients with chronic liver disease. Aim of this study was to identify clinical and laboratory predictors of esophageal varices in children with chronic liver disease. This cross sectional observational study was done at Pediatric Gastroenterology and Nutrition Department of Bangabandhu Sheikh Mujib Medical University, Dhaka, over a period of 6 months...
April 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28514463/pediatric-psoriasis-comorbidity-screening-guidelines
#3
Emily Osier, Audrey S Wang, Megha M Tollefson, Kelly M Cordoro, Stephen R Daniels, Andrew Eichenfield, Joel M Gelfand, Alice B Gottlieb, Alexa B Kimball, Mark Lebwohl, Nehal N Mehta, Amy S Paller, Jeffrey B Schwimmer, Dennis M Styne, Abby S Van Voorhees, Wynnis L Tom, Lawrence F Eichenfield
Importance: Psoriasis is a complex inflammatory skin condition associated with serious medical comorbidities in adults, including obesity, hypertension, dyslipidemia, type 2 diabetes mellitus, psoriatic arthritis, nonalcoholic fatty liver disease, depression, anxiety, and decreased quality of life. Because psoriasis begins in childhood in almost one-third of patients, early identification of risk may be critical to minimizing effects on future health. Objective: To develop the first set of guidelines for comorbidity screening for patients with pediatric psoriasis based on current evidence...
July 1, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28242319/white-paper-aga-power-practice-guide-on-obesity-and%C3%A2-weight-management-education-and-resources
#4
REVIEW
Andres Acosta, Sarah Streett, Mathew D Kroh, Lawrence J Cheskin, Katherine H Saunders, Marina Kurian, Marsha Schofield, Sarah E Barlow, Louis Aronne
The epidemic of obesity continues at alarming rates, with a high burden to our economy and society. The American Gastroenterological Association understands the importance of embracing obesity as a chronic, relapsing disease and supports a multidisciplinary approach to the management of obesity. Because gastrointestinal disorders resulting from obesity are more frequent and often present sooner than type 2 diabetes mellitus and cardiovascular disease, gastroenterologists have an opportunity to address obesity and provide an effective therapy early...
May 2017: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28107283/naspghan-clinical-practice-guideline-for-the-diagnosis-and-treatment-of-nonalcoholic-fatty-liver-disease-in-children-recommendations-from-the-expert-committee-on-nafld-econ-and-the-north-american-society-of-pediatric-gastroenterology-hepatology-and-nutrition
#5
Miriam B Vos, Stephanie H Abrams, Sarah E Barlow, Sonia Caprio, Stephen R Daniels, Rohit Kohli, Marialena Mouzaki, Pushpa Sathya, Jeffrey B Schwimmer, Shikha S Sundaram, Stavra A Xanthakos
Nonalcoholic fatty liver disease (NAFLD) is a highly prevalent chronic liver disease that occurs in the setting of insulin resistance and increased adiposity. It has rapidly evolved into the most common liver disease seen in the pediatric population and is a management challenge for general pediatric practitioners, subspecialists, and for health systems. In this guideline, the expert committee on NAFLD reviewed and summarized the available literature, formulating recommendations to guide screening and clinical care of children with NAFLD...
February 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27975109/cholestasis-in-infancy
#6
Melissa G Andrianov, Ruba K Azzam
Jaundice is a key manifestation of hepatobiliary disease in all age groups. Jaundice is a common finding in the first 2 weeks after birth, occurring in 2.4% to 15% of newborns. The neonatal liver is at increased susceptibility to cholestasis, with an incidence ranging from 1 in 2,500 to 1 in 5,000 live births. Etiologies vary, but the most common is biliary atresia. In 2004, the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition published guidelines for the evaluation of cholestasis that clearly stated any infant with jaundice persisting beyond age 2 weeks (3 weeks in breast-fed infants with an otherwise normal history and physical examination) should be evaluated with a fractionated serum bilirubin level...
December 1, 2016: Pediatric Annals
https://www.readbyqxmd.com/read/27565547/evidence-informed-expert-recommendations-for-the-management-of-celiac-disease-in-children
#7
John Snyder, J Decker Butzner, Amy R DeFelice, Alessio Fasano, Stefano Guandalini, Edwin Liu, Kimberly P Newton
Although the need for effective long-term follow-up for patients with celiac disease (CD) has been recognized by many expert groups, published practice guidelines have not provided a clear approach for the optimal management of these patients. In an attempt to provide a thoughtful and practical approach for managing these patients, a group of experts in pediatric CD performed a critical review of the available literature in 6 categories associated with CD to develop a set of best practices by using evidence-based data and expert opinion...
September 2016: Pediatrics
https://www.readbyqxmd.com/read/27429428/guideline-for-the-evaluation-of-cholestatic-jaundice-in-infants-joint-recommendations-of-the-north-american-society-for-pediatric-gastroenterology-hepatology-and-nutrition-and-the-european-society-for-pediatric-gastroenterology-hepatology-and-nutrition
#8
Rima Fawaz, Ulrich Baumann, Udeme Ekong, Björn Fischler, Nedim Hadzic, Cara L Mack, Valérie A McLin, Jean P Molleston, Ezequiel Neimark, Vicky L Ng, Saul J Karpen
Cholestatic jaundice in infancy affects approximately 1 in every 2500 term infants and is infrequently recognized by primary providers in the setting of physiologic jaundice. Cholestatic jaundice is always pathologic and indicates hepatobiliary dysfunction. Early detection by the primary care physician and timely referrals to the pediatric gastroenterologist/hepatologist are important contributors to optimal treatment and prognosis. The most common causes of cholestatic jaundice in the first months of life are biliary atresia (25%-40%) followed by an expanding list of monogenic disorders (25%), along with many unknown or multifactorial (eg, parenteral nutrition-related) causes, each of which may have time-sensitive and distinct treatment plans...
January 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/27305414/prevalence-of-malnutrition-in-children-with-chronic-hepatitis-b-infection
#9
Yasin Şahin
BACKGROUND: There have been limited studies investigating the impact of chronic hepatitis B virus infection on the growth of children. OBJECTIVE: Our objective was to investigate the prevalence of malnutrition in children with chronic hepatitis B infection. METHODS: The nutritional status of patients was retrospectively evaluated in the outpatient Clinic of Pediatric Gastroenterology between February and November 2014. During the study, biochemical laboratory parameters, duration of disease, liver biopsy scores, and medication were evaluated...
April 2016: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/26840667/classical-galactosemia-among-indian-children-presentation-and-outcome-from-a-pediatric-gastroenterology-center
#10
Moinak Sen Sarma, Anshu Srivastava, Surender Kumar Yachha, Ujjal Poddar, Amrita Mathias
OBJECTIVE: To analyze the presentation and predictors of outcome of children with galactosemia. METHODS: Analysis of clinical, laboratory, microbiological profile and outcome of patients fulfilling the diagnostic criteria: i) clinical setting; ii) reduced erythrocyte Gal-1-PUT enzyme activity; and iii) unequivocal response to lactose-free diet. RESULTS: 24 patients; median age of symptom onset and diagnosis: 10 (3-75) d and 55 (15-455) days, respectively...
January 2016: Indian Pediatrics
https://www.readbyqxmd.com/read/26486286/evaluation-of-leukocyte-esterase-reagent-strips-test-in-the-diagnosis-of-spontaneous-bacterial-peritonitis-in-children-with-cirrhosis
#11
Naser Honar, Bita Geramizadeh, Seyed-Mohsen Dehghani, Gholamreza Kalvandi, Iraj Shahramian, Asghar Rahmani, Hazhir Javaherizadeh
BACKGROUND: Spontaneous bacterial peritonitis is defined as an ascetic fluid infection without an evident intra-abdominal surgically treatable source. Spontaneous bacterial peritonitis is one of the severe complications in patients with cirrhosis and ascites. Without early antibiotic treatment, this complication is associated with high mortality rate; therefore, early diagnosis and treatment of spontaneous bacterial peritonitis is necessary for survival. Leukocyte esterase reagent can rapidly diagnose the spontaneous bacterial peritonitis...
July 2015: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/25900957/molecular-characterization-of-hepatitis-a-virus-strains-in-a-tertiary-care-health-set-up-in-north-western-india
#12
Mini Pritam Singh, Manasi Majumdar, Babu Ram Thapa, Puneet Kumar Gupta, Jasmine Khurana, Bimal Budhathoki, Radha Kanta Ratho
BACKGROUND & OBJECTIVES: Hepatitis A virus usually causes acute viral hepatitis (AVH) in the paediatric age group with a recent shift in age distribution and disease manifestations like acute liver failure (ALF). This has been attributed to mutations in 5'non-translated region (5'NTR) which affects the viral multiplication. The present study was aimed to carry out the molecular detection and phylogenetic analysis of hepatitis A virus strains circulating in north western India. METHODS: Serum samples from in patients and those attending out patient department of Pediatric Gastroenterology in a tertiary care hospital in north India during 2007-2011 with clinically suspected AVH were tested for anti-hepatitis A virus (HAV) IgM antibodies...
February 2015: Indian Journal of Medical Research
https://www.readbyqxmd.com/read/25891513/analysis-of-breath-volatile-organic-compounds-in-children-with-chronic-liver-disease-compared-to-healthy-controls
#13
Katharine Eng, Naim Alkhouri, Frank Cikach, Nishaben Patel, Chen Yan, David Grove, Rocio Lopez, Ellen Rome, Raed A Dweik
Breath testing is increasingly being used as a non-invasive diagnostic tool for disease states across medicine. The purpose of this study was to compare the levels of volatile organic compounds (VOCs) as measured by mass spectrometry in healthy children and children with chronic liver disease (CLD). Patients between the ages of 6 and 21 were recruited for the study. Control subjects were recruited from a general pediatric population during well-child visits, while patients with CLD were recruited from pediatric gastroenterology clinic visits...
June 2015: Journal of Breath Research
https://www.readbyqxmd.com/read/25717240/chronic-hepatitis-b-in-children-with-or-without-malignancies-a-13-year-follow-up
#14
Merve Usta, Nafiye Urgancı, Zeynep Yıldız Yıldırmak, Sema Dogan Vural
AIM: To evaluate the outcome of chronic hepatitis B (CHB) in children with or without malignancies. METHODS: Twenty four children (15 boys and 9 girls) with malignancies, followed up by the pediatric gastroenterology outpatient clinic for CHB between January 2000 and December 2013, were enrolled in the study (Group 1). Group 2 was formed with twenty five children (11 girls and 14 boys) diagnosed with CHB without malignancies. The data from the patients' records were compared between the two groups...
February 21, 2015: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25222807/evaluation-of-the-pediatric-patient-for-liver-transplantation-2014-practice-guideline-by-the-american-association-for-the-study-of-liver-diseases-american-society-of-transplantation-and-the-north-american-society-for-pediatric-gastroenterology-hepatology-and
#15
Robert H Squires, Vicky Ng, Rene Romero, Udeme Ekong, Winita Hardikar, Sukru Emre, George V Mazariegos
No abstract text is available yet for this article.
July 2014: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/25088269/nonalcoholic-fatty-liver-disease-in-children-recent-practice-guidelines-where-do-they-take-us
#16
REVIEW
Ashish Aggarwal, Kanika Puri, Suraj Thangada, Nizar Zein, Naim Alkhouri
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children and adolescents in the United States. It is strongly associated with childhood obesity, insulin resistance and metabolic syndrome. Although some children with NAFLD may remain asymptomatic, progression to nonalcoholic steatohepatitis (NASH), and to advanced stages of fibrosis and cirrhosis is well recognized. Unfortunately, despite the increase in awareness of this disease, there are still no reliable non-invasive diagnostic tests and liver biopsy remains the gold standard for the diagnosis of NASH and staging of fibrosis...
2014: Current Pediatric Reviews
https://www.readbyqxmd.com/read/24950640/entrustable-professional-activities-for-gastroenterology-fellowship-training
#17
Suzanne Rose, Oren K Fix, Brijen J Shah, Tamara N Jones, Ronald D Szyjkowski, Brian P Bosworth, Kathy Bull-Henry, Walter Coyle, C Prakash Gyawali, Ayman Koteish, Jane Onken, John Pandolfino, Darrell Pardi, Gautham Reddy, Seth Richter, Thomas J Savides, Robert E Sedlack
No abstract text is available yet for this article.
July 2014: Gastrointestinal Endoscopy
https://www.readbyqxmd.com/read/24829669/etiology-and-complications-of-liver-cirrhosis-in-children-report-of-a-single-center-from-southern-iran
#18
Seyed Mohsen Dehghani, Mohammad Hadi Imanieh, Mahmood Haghighat, Abdorrasoul Malekpour, Zeinab Falizkar
BACKGROUND: Liver cirrhosis is one of the major causes of hospitalization and mortality in children. A wide spectrum of disorders including developmental abnormalities, infections, metabolic and genetic disorders can lead to liver cirrhosis in pediatric patients. Determination of its etiology is important for treatment, prevention of progressive liver damage, family counseling and prioritizing liver transplantation. The aim of this study is to evaluate causes of liver cirrhosis in children in Southern Iran...
January 2013: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/24829658/etiology-of-portal-hypertension-in-children-a-single-center-s-experiences
#19
Mohammad Hadi Imanieh, Seyed Mohsen Dehghani, Maryam Khoshkhui, Abdorrasoul Malekpour
BACKGROUND: All conditions that interfere with blood flow at any level within the portal system can lead to portal hypertension. For better management of this disorder, it is important to determine the underlying cause. In previous studies, extra-hepatic disorders have been reported as the main cause of portal hypertension in children. In this study, we investigate the underlying causes of portal hypertension in children. METHODS: This prospective, descriptive study investigated the etiology of 45 children with portal hypertension who referred to Nemazee Hospital Pediatric Gastroenterology Ward from 2005 to 2007...
October 2012: Middle East Journal of Digestive Diseases
https://www.readbyqxmd.com/read/24796801/research-and-the-promotion-of-child-health-a-position-paper-of-the-european-society-for-pediatric-gastroenterology-hepatology-and-nutrition
#20
Berthold Koletzko, Sanja Kolacek, Alan Phillips, Riccardo Troncone, Yvan Vandenplas, Nikhil Thapar, Ulrich Baumann, Johannes van Goudoever, Walter Mihatsch, Casper de Swarte, Marc Benninga, Luisa Mearin
Children comprise one-fifth of Europe's population. Promoting child health and development is of key importance for society and its future. This position paper highlights opportunities of investing in gastrointestinal, liver, and nutritional research to promote child health and delineates priorities for research. Investing in child health plays a key role in the promotion of population health, well-being, and disease prevention lifelong, with large health economic benefits. Major opportunities for improving knowledge and translational application arise from recent scientific and technological developments, for example, the long-term impact of early environmental cues interacting with genes...
August 2014: Journal of Pediatric Gastroenterology and Nutrition
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