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Liver, gastroenterology, pediatrics

John Snyder, J Decker Butzner, Amy R DeFelice, Alessio Fasano, Stefano Guandalini, Edwin Liu, Kimberly P Newton
Although the need for effective long-term follow-up for patients with celiac disease (CD) has been recognized by many expert groups, published practice guidelines have not provided a clear approach for the optimal management of these patients. In an attempt to provide a thoughtful and practical approach for managing these patients, a group of experts in pediatric CD performed a critical review of the available literature in 6 categories associated with CD to develop a set of best practices by using evidence-based data and expert opinion...
September 2016: Pediatrics
Rima Fawaz, Ulrich Baumann, Udeme Ekong, Björn Fischler, Nedim Hadzic, Cara L Mack, Valérie A McLin, Jean P Molleston, Ezequiel Neimark, Vicky Lee Ng, Saul J Karpen
Cholestatic jaundice in infancy affects approximately 1 in every 2500 term infants and is infrequently recognized by primary providers in the setting of physiologic jaundice. Cholestatic jaundice is always pathologic and indicates hepatobiliary dysfunction. Early detection by the primary care physician and timely referrals to the pediatric gastroenterologist/hepatologist are important contributors to optimal treatment and prognosis. The most common causes of cholestatic jaundice in the first months of life are biliary atresia (BA, 25-40%) followed by an expanding list of monogenic disorders (25%), plus many unknown or multifactorial (e...
July 16, 2016: Journal of Pediatric Gastroenterology and Nutrition
Yasin Şahin
BACKGROUND: There have been limited studies investigating the impact of chronic hepatitis B virus infection on the growth of children. OBJECTIVE: Our objective was to investigate the prevalence of malnutrition in children with chronic hepatitis B infection. METHODS: The nutritional status of patients was retrospectively evaluated in the outpatient Clinic of Pediatric Gastroenterology between February and November 2014. During the study, biochemical laboratory parameters, duration of disease, liver biopsy scores, and medication were evaluated...
April 2016: Arquivos de Gastroenterologia
Moinak Sen Sarma, Anshu Srivastava, Surender Kumar Yachha, Ujjal Poddar, Amrita Mathias
OBJECTIVE: To analyze the presentation and predictors of outcome of children with galactosemia. METHODS: Analysis of clinical, laboratory, microbiological profile and outcome of patients fulfilling the diagnostic criteria: i) clinical setting; ii) reduced erythrocyte Gal-1-PUT enzyme activity; and iii) unequivocal response to lactose-free diet. RESULTS: 24 patients; median age of symptom onset and diagnosis: 10 (3-75) d and 55 (15-455) days, respectively...
January 2016: Indian Pediatrics
Naser Honar, Bita Geramizadeh, Seyed-Mohsen Dehghani, Gholamreza Kalvandi, Iraj Shahramian, Asghar Rahmani, Hazhir Javaherizadeh
BACKGROUND: Spontaneous bacterial peritonitis is defined as an ascetic fluid infection without an evident intra-abdominal surgically treatable source. Spontaneous bacterial peritonitis is one of the severe complications in patients with cirrhosis and ascites. Without early antibiotic treatment, this complication is associated with high mortality rate; therefore, early diagnosis and treatment of spontaneous bacterial peritonitis is necessary for survival. Leukocyte esterase reagent can rapidly diagnose the spontaneous bacterial peritonitis...
July 2015: Arquivos de Gastroenterologia
Mini Pritam Singh, Manasi Majumdar, Babu Ram Thapa, Puneet Kumar Gupta, Jasmine Khurana, Bimal Budhathoki, Radha Kanta Ratho
BACKGROUND & OBJECTIVES: Hepatitis A virus usually causes acute viral hepatitis (AVH) in the paediatric age group with a recent shift in age distribution and disease manifestations like acute liver failure (ALF). This has been attributed to mutations in 5'non-translated region (5'NTR) which affects the viral multiplication. The present study was aimed to carry out the molecular detection and phylogenetic analysis of hepatitis A virus strains circulating in north western India. METHODS: Serum samples from in patients and those attending out patient department of Pediatric Gastroenterology in a tertiary care hospital in north India during 2007-2011 with clinically suspected AVH were tested for anti-hepatitis A virus (HAV) IgM antibodies...
February 2015: Indian Journal of Medical Research
Katharine Eng, Naim Alkhouri, Frank Cikach, Nishaben Patel, Chen Yan, David Grove, Rocio Lopez, Ellen Rome, Raed A Dweik
Breath testing is increasingly being used as a non-invasive diagnostic tool for disease states across medicine. The purpose of this study was to compare the levels of volatile organic compounds (VOCs) as measured by mass spectrometry in healthy children and children with chronic liver disease (CLD). Patients between the ages of 6 and 21 were recruited for the study. Control subjects were recruited from a general pediatric population during well-child visits, while patients with CLD were recruited from pediatric gastroenterology clinic visits...
June 2015: Journal of Breath Research
Merve Usta, Nafiye Urgancı, Zeynep Yıldız Yıldırmak, Sema Dogan Vural
AIM: To evaluate the outcome of chronic hepatitis B (CHB) in children with or without malignancies. METHODS: Twenty four children (15 boys and 9 girls) with malignancies, followed up by the pediatric gastroenterology outpatient clinic for CHB between January 2000 and December 2013, were enrolled in the study (Group 1). Group 2 was formed with twenty five children (11 girls and 14 boys) diagnosed with CHB without malignancies. The data from the patients' records were compared between the two groups...
February 21, 2015: World Journal of Gastroenterology: WJG
Robert H Squires, Vicky Ng, Rene Romero, Udeme Ekong, Winita Hardikar, Sukru Emre, George V Mazariegos
No abstract text is available yet for this article.
July 2014: Journal of Pediatric Gastroenterology and Nutrition
Ashish Aggarwal, Kanika Puri, Suraj Thangada, Nizar Zein, Naim Alkhouri
Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children and adolescents in the United States. It is strongly associated with childhood obesity, insulin resistance and metabolic syndrome. Although some children with NAFLD may remain asymptomatic, progression to nonalcoholic steatohepatitis (NASH), and to advanced stages of fibrosis and cirrhosis is well recognized. Unfortunately, despite the increase in awareness of this disease, there are still no reliable non-invasive diagnostic tests and liver biopsy remains the gold standard for the diagnosis of NASH and staging of fibrosis...
2014: Current Pediatric Reviews
Suzanne Rose, Oren K Fix, Brijen J Shah, Tamara N Jones, Ronald D Szyjkowski, Brian P Bosworth, Kathy Bull-Henry, Walter Coyle, C Prakash Gyawali, Ayman Koteish, Jane Onken, John Pandolfino, Darrell Pardi, Gautham Reddy, Seth Richter, Thomas J Savides, Robert E Sedlack
No abstract text is available yet for this article.
July 2014: Gastrointestinal Endoscopy
Seyed Mohsen Dehghani, Mohammad Hadi Imanieh, Mahmood Haghighat, Abdorrasoul Malekpour, Zeinab Falizkar
BACKGROUND: Liver cirrhosis is one of the major causes of hospitalization and mortality in children. A wide spectrum of disorders including developmental abnormalities, infections, metabolic and genetic disorders can lead to liver cirrhosis in pediatric patients. Determination of its etiology is important for treatment, prevention of progressive liver damage, family counseling and prioritizing liver transplantation. The aim of this study is to evaluate causes of liver cirrhosis in children in Southern Iran...
January 2013: Middle East Journal of Digestive Diseases
Mohammad Hadi Imanieh, Seyed Mohsen Dehghani, Maryam Khoshkhui, Abdorrasoul Malekpour
BACKGROUND: All conditions that interfere with blood flow at any level within the portal system can lead to portal hypertension. For better management of this disorder, it is important to determine the underlying cause. In previous studies, extra-hepatic disorders have been reported as the main cause of portal hypertension in children. In this study, we investigate the underlying causes of portal hypertension in children. METHODS: This prospective, descriptive study investigated the etiology of 45 children with portal hypertension who referred to Nemazee Hospital Pediatric Gastroenterology Ward from 2005 to 2007...
October 2012: Middle East Journal of Digestive Diseases
Berthold Koletzko, Sanja Kolacek, Alan Phillips, Riccardo Troncone, Yvan Vandenplas, Nikhil Thapar, Ulrich Baumann, Johannes van Goudoever, Walter Mihatsch, Casper de Swarte, Marc Benninga, Luisa Mearin
Children comprise one-fifth of Europe's population. Promoting child health and development is of key importance for society and its future. This position paper highlights opportunities of investing in gastrointestinal, liver, and nutritional research to promote child health and delineates priorities for research. Investing in child health plays a key role in the promotion of population health, well-being, and disease prevention lifelong, with large health economic benefits. Major opportunities for improving knowledge and translational application arise from recent scientific and technological developments, for example, the long-term impact of early environmental cues interacting with genes...
August 2014: Journal of Pediatric Gastroenterology and Nutrition
Robert H Squires, Vicky Ng, Rene Romero, Udeme Ekong, Winita Hardikar, Sukru Emre, George V Mazariegos
No abstract text is available yet for this article.
July 2014: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
Vidyut Bhatia, Ashish Bavdekar, John Matthai, Yogesh Waikar, Anupam Sibal
JUSTIFICATION: Neonatal cholestasis is an important cause of chronic liver disease in young children. Late referral and lack of precise etiological diagnosis are reasons for poor outcome in substantial number of cases in India. There is a need to create better awareness among the pediatricians, obstetricians and primary care physicians on early recognition, prompt evaluation and referral to regional centers. PROCESS: Eminent national faculty members were invited to participate in the process of forming a consensus statement...
March 2014: Indian Pediatrics
Fawaz Al-Refaee
Liver involvement in pediatric influenza A (H1N1) infection is rare. Focused clinical evaluation and laboratory tests can rule out or identify hepatic complications early on. Here we report on a 9-year-old boy treated by the Gastroenterology, Hepatology, and Nutrition Unit of Al-Adan Hospital's Pediatric Department. The patient, who was infected with H1N1 during the 2010 pandemic, showed symptoms of associated acute hepatic failure, was managed conservatively, and recovered completely following treatment. The author would like to draw the attention of pediatricians to the hepatic aspect of human H1N1 infection in order for them to recognize it early and treat it in a timely manner...
2012: Hepatic Medicine: Evidence and Research
Michael J Lentze
No abstract text is available yet for this article.
January 2014: Journal of Pediatric Gastroenterology and Nutrition
Diana G Lerner, B U Li, Petar Mamula, Douglas S Fishman, Robert Kramer, Vi Lier Goh, Khalil El-Chammas, Scott P Pentiuk, Robert Rothbaum, Bhaskar Gurrum, Riad M Rahhal, Praveen S Goday, Bernadette Vitola
OBJECTIVE: The aims of this study were to assess the opportunities for therapeutic endoscopy, liver biopsies, and percutaneous endoscopic gastrostomy (PEG) placements available to fellows during a 3-year pediatric gastroenterology fellowship, and to evaluate access to ancillary procedural-training opportunities. METHODS: Data were collected from 12 pediatric gastroenterology fellowship programs in the United States. Procedures completed in the years 2009-2011 were queried using CPT codes and endoscopy databases...
January 2014: Journal of Pediatric Gastroenterology and Nutrition
J Flores-Calderón
No abstract text is available yet for this article.
August 2013: Revista de Gastroenterología de México
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