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Danielle I Stanisic, James S McCarthy, Michael F Good
Controlled human malaria infection (CHMI) entails deliberate infection with malaria parasites either by mosquito bite or by direct injection of sporozoites or parasitized erythrocytes. When required, the resulting blood-stage infection is curtailed by the administration of antimalarial drugs. Inducing a malaria infection via inoculation with infected blood was first used as a treatment (malariotherapy) for neurosyphilis in Europe and the United States in the early 1900s. More recently, CHMI has been applied to the fields of malaria vaccine and drug development, where it is used to evaluate products in well-controlled early-phase proof-of-concept clinical studies, thus facilitating progression of only the most promising candidates for further evaluation in areas where malaria is endemic...
January 2018: Infection and Immunity
Cyrus Daneshvar, Timothy William, Timothy M E Davis
Plasmodium knowlesi is a simian malaria of primarily the macaque species of South East Asia. While it was known that human infections could be induced during the years of malariotherapy, naturally occurring P. knowlesi human infections were thought to be rare. However, in 2004, knowlesi infections became recognized as an important infection amongst human populations in Sarawak, Malaysian Borneo. Since then, it has become recognized as a disease affecting people living and visiting endemic areas across South East Asia...
January 26, 2017: Parasitology
Remington L Nevin, Ashley M Croft
The modern medical literature implicates malaria, and particularly the potentially fatal form of cerebral malaria, with a risk of neurocognitive impairment. Yet historically, even milder forms of malaria were associated in the literature with a broad range of psychiatric effects, including disorders of personality, mood, memory, attention, thought, and behaviour. In this article, the history of psychiatric effects attributed to malaria and post-malaria syndromes is reviewed, and insights from the historical practice of malariotherapy in contributing to understanding of these effects are considered...
June 22, 2016: Malaria Journal
Pierre L Thillaud, Jacques Postel
In July 1974, a 72 old woman had been a patient for forty years in Sainte-Anne Hospital, Ward C. As she had again a violent brawl with her neighbour patient, she revealed being a tremendous artist. She had been confined on account of dementia paralytica in the Mecca of malariotherapy, and passionately devoted herself to embroidery. Her fancy work was rather a matter for Jean Dubuffet's art through its perfect expression and deserved being known.
April 2014: Histoire des Sciences Médicales
Georges Snounou, Jean-Louis Pérignon
From the early 1920s until the advent of penicillin in the mid 1940s, a clinical course of malaria was the only effective treatment of general paresis, a common manifestation of tertiary syphilis that was nearly always fatal. For a number of reasons, Plasmodium vivax became the parasite species most often employed for what became known as malariotherapy. This provided an opportunity, probably unique in the annals of medicine, to observe and investigate the biology, immunology and clinical evolution of a dangerous human pathogen in its natural host...
2013: Advances in Parasitology
Robert M Kaplan
OBJECTIVE: A movie on malariotherapy for neurosyphilis made at Mont Park and filmed by Reg Ellery in 1926 is believed to be the oldest surviving movie of psychiatric treatment in Australia. The objective is to review the movie and discuss the background and context of the film, which shows the conditions of patients in a psychiatric hospital in the 1920s. CONCLUSION: Movie film is a guide to a psychiatric past that is rapidly being forgotten. The Ellery movie is an incentive to collect surviving footage before it is too late...
February 2013: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
Robert M Kaplan
OBJECTIVE: To explore the life and contributions of Reginald Spencer Ellery (1897-1955), one of the most eminent psychiatrists in Australia between the wars. CONCLUSIONS: Ellery pioneered malariotherapy and psychoanalysis, mixed with leading intellectuals, including Max Harris, John and Sunday Reed, was a member of the Communist Party, wrote poetry and published widely on a wide range of topics. Ellery was talented, innovative, driven and highly energetic, managing a range of activities aside from his work without difficulty...
February 2012: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
No abstract text is available yet for this article.
April 1946: Revista Paulista de Medicina
Robert M Kaplan
OBJECTIVES: Syphilis has changed the course of history, shaped the path of medicine and had more influence on psychiatry than any other illness. This paper, part two of a two-part series, investigates the historical, social and cultural aspects of the interaction of syphilis and psychiatry. CONCLUSION: By the end of the 19th century, social changes such as population growth, mass migration from Eastern Europe and technological developments led to a great rise in syphilis...
February 2010: Australasian Psychiatry: Bulletin of Royal Australian and New Zealand College of Psychiatrists
J Teun Bousema, Chris J Drakeley, Petra F Mens, Theo Arens, Rein Houben, Sabah A Omar, Louis C Gouagna, Henk Schallig, Robert W Sauerwein
Plasmodium falciparum and P. malariae occur endemically in many parts of Africa. Observations from malariotherapy patients suggest that co-infection with P. malariae may increase P. falciparum gametocyte production. We determined P. falciparum gametocyte prevalence and density by quantitative nucleic acid sequence-based amplification (QT-NASBA) after antimalarial treatment of Kenyan children with either P. falciparum mono-infection or P. falciparum and P. malariae mixed infection. In addition, we analyzed the relationship between mixed species infections and microscopic P...
March 2008: American Journal of Tropical Medicine and Hygiene
No abstract text is available yet for this article.
1948: Duodecim; Lääketieteellinen Aikakauskirja
No abstract text is available yet for this article.
September 1, 1950: Nordisk Medicin
(no author information available yet)
No abstract text is available yet for this article.
October 15, 1950: Zeitschrift Für Haut- und Geschlechtskrankheiten
Xiaoping Chen, Binquan Xiao, Wenjun Shi, Huifang Xu, Kai Gao, Jili Rao, Zhoubin Zhang
OBJECTIVE: To explore the mechanisms of malariotherapy for human immunodeficiency virus (HIV)-infected patients and to identify which stage(s) of HIV infection is suitable for the treatment of malariotherapy. METHODS: Therapeutic acute vivax malaria was induced and terminated after 10 fever episodes in 12 HIV-1-infected subjects: Group 1 (G1) had 5 patients with CD(4) T-cell counts >or=500/ micro l at baseline, Group 2 (G2) had 5 patients with CD4 at 499 - 200/ micro l and Group 3 had 2 patients with CD(4) < 200/ micro l (not included in statistical analysis)...
December 2003: Chinese Medical Journal
No abstract text is available yet for this article.
August 1959: Giornale di Clinica Medica
No abstract text is available yet for this article.
1955: Revue Neurologique
No abstract text is available yet for this article.
February 8, 1965: Il Policlinico. Sezione Pratica
No abstract text is available yet for this article.
September 1963: Archives Roumaines de Pathologie Expérimentales et de Microbiologie
No abstract text is available yet for this article.
July 14, 1962: Minerva Medica
No abstract text is available yet for this article.
July 11, 1960: Il Policlinico. Sezione Pratica
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