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Topical nutraceuticals

Farid Chemat, Natacha Rombaut, Anne-Gaëlle Sicaire, Alice Meullemiestre, Anne-Sylvie Fabiano-Tixier, Maryline Abert-Vian
This review presents a complete picture of current knowledge on ultrasound-assisted extraction (UAE) in food ingredients and products, nutraceutics, cosmetic, pharmaceutical and bioenergy applications. It provides the necessary theoretical background and some details about extraction by ultrasound, the techniques and their combinations, the mechanisms (fragmentation, erosion, capillarity, detexturation, and sonoporation), applications from laboratory to industry, security, and environmental impacts. In addition, the ultrasound extraction procedures and the important parameters influencing its performance are also included, together with the advantages and the drawbacks of each UAE techniques...
January 2017: Ultrasonics Sonochemistry
Zhenbin Wang, Qing Wang, Lin Wang, Weidong Xu, Yuanqing He, Yunliang Li, Song He, Haile Ma
BACKGROUND: Collagen hydrolysates (CHs) has been demonstrated to have positive effect on skin photo-aging by topical application or oral ingestion. However, there's little report about its influence on skin chronological aging so far. RESULTS: Nine-month-old female ICR mice were given normal AIN-93M diets containing the CHs (2.5%, 5% and 10%, respectively) from Nile tilapia scale. After 6 months, the collagen content and antioxidant enzymes (superoxide dismutase and glutathione peroxidase) activities significantly increased (p < 0...
October 17, 2016: Journal of the Science of Food and Agriculture
Christian R Vogl, Brigitte Vogl-Lukasser, Michael Walkenhorst
BACKGROUND: The sustainable management of animal health and welfare is of increasing importance to consumers and a key topic in the organic farming movement. Few systematic studies have been undertaken investigating farmers' local knowledge related to this issue. Ethnoveterinary medicine (EVM) is a discipline focusing on local knowledge and folk methods in veterinary medicine, however most ethnoveterinarian studies primarily address the treatment of animal diseases. Very few studies have explored prophylactic methods...
2016: Journal of Ethnobiology and Ethnomedicine
Pasquale Del Gaudio, Francesca Sansone, Teresa Mencherini, Felicetta De Cicco, Paola Russo, Rita Patrizia Aquino
Pharmacological evidences have correlated a low incidence of osteoporosis, breast cancer, cardiovascular disease, and colon cancer in Asian populations, high consumers of soya, to the properties of soy isoflavones, more specifically to daidzein and genistein. However, in spite of the potent biological activity, their poor water solubility has a strong negative effect on bioavailability. In this study, an innovative technique, nano spray drying, was used to obtain nanoparticles loaded with a soybean dry extract while carboxymethyl cellulose was used as the excipient...
June 24, 2016: Planta Medica
Steve Schwartz, Emily Frank, Dennis Gierhart, Paula Simpson, Robert Frumento
BACKGROUND: Dietary modification, through supplementation and elimination diets, has become an area of interest to help slow skin aging, reduce symptom severity or prevent reoccurrence of certain dermatologic conditions [Clinical Dermatology vol. 31 (2013) 677-700]. Free radical components (reactive oxygen species or ROS) or lipid peroxide (LPO) is involved in the pathogenesis and progression of accelerated skin aging when prolonged oxidative stress occurs. The use of antioxidant-related therapies such as nutraceuticals is of particular interest in restoring skin homeostasis...
June 17, 2016: Journal of Cosmetic Dermatology
Jesús Tellez-Vazquez
PURPOSE: The purpose of this study is to assess the effectiveness and tolerability of a dietary supplement with a combination of omega-3 fatty acids and antioxidants on dry eye symptoms caused by chronic instillation of antihypertensive eye drops in patients with glaucoma. PATIENTS AND METHODS: A total of 1,255 patients with glaucoma and dry eye symptoms related to antiglaucoma topical medication participated in an open-label, uncontrolled, prospective, and multicenter study and were instructed to take three capsules a day of the nutraceutical formulation (Brudypio(®) 1...
2016: Clinical Ophthalmology
Francisco Cabello-Hurtado, Jean Keller, José Ley, Rosa Sanchez-Lucas, Jesús V Jorrín-Novo, Abdelkader Aïnouche
UNLABELLED: Lupins have a variety of both traditional and modern uses. In the last decade, reports assessing the benefits of lupin seed proteins have proliferated and, nowadays, the pharmaceutical industry is interested in lupin proteins for human health. Modern genomics and proteomics have hugely contributed to describing the diversity of lupin storage genes and, above all, proteins. Most of these studies have been centered on few edible lupin species. However, Lupinus genus comprises hundreds of species spread throughout the Old and New Worlds, and these resources have been scarcely explored and exploited...
June 30, 2016: Journal of Proteomics
Irlan Almeida Freires, Severino Matias de Alencar, Pedro Luiz Rosalen
Propolis is a complex resinous mixture collected by bees, with high medicinal, historical and economic value. The nutraceutical and pharmacological benefits of propolis have been extensively explored in several fields of medicine as an important resource for prevention and treatment of oral and systemic diseases. A relatively new type of propolis, named red propolis (in Brazil, Brazilian Red Propolis - BRP), has been arousing attention for the promising pharmacological properties of some of its isolated compounds (vestitol, neovestitol, quercetin, medicarpin, formononetin, etc)...
March 3, 2016: European Journal of Medicinal Chemistry
Claudio Bucolo, Maria Musumeci, Salvatore Salomone, Giovanni Luca Romano, Gian Marco Leggio, Caterina Gagliano, Michele Reibaldi, Teresio Avitabile, Maurizio G Uva, Salvatore Musumeci, Filippo Drago
PURPOSE: Colostrum has been proposed to treat severe dryness and problematic eye lesions showing a beneficial effect. The aim of the study was to investigate the effect of 2-fucosyl-lactose, a natural sugar present in the human colostrum, in an experimental dry eye. METHODS: Dry eye was induced in adult male New Zealand albino rabbits by topical administration of 1% atropine. Tear volume (Schirmer's test), tear film breakup time (TBUT), corneal staining and tear osmolarity were assessed...
2015: Frontiers in Pharmacology
Seyed Mohammad Nabavi, Maria Daglia, Nady Braidy, Seyed Fazel Nabavi
Objectives Depression is one of the most common psychiatric disorders, and the fourth leading cause of long-term disability throughout the world. Despite the availability of different classes of antidepressant drugs, most of them are not completely effective and above all are associated with many serious adverse effects. Recently, accumulating evidence suggests that dietary supplements rich in important phytochemicals possess beneficial therapeutic roles in depression. Methods In this review, we will first consider what is known about the pathogenesis of depression and discuss the need for more safe and efficacious treatment...
November 27, 2015: Nutritional Neuroscience
Davide Grassi, Claudio Ferri, Giovambattista Desideri
Cognitive decline and dementia are major public health social problems, suggesting the specific need to provide research into risk factors for cognitive decline as priority topic. Increasing evidence supports the hypothesis that oxidative stress and neuroinflammation might play a crucial role in the pathophysiology of cognitive decline. Further, cognitive dysfunction and dementia in Alzheimer's disease as well as in vascular dementia seem to be also the consequence of cerebral blood flow decrease and deregulation, also suggesting a putative pathophysiological convergence of mechanisms between atherosclerosis and Alzheimer's disease...
2016: Current Pharmaceutical Design
Adil Salhi, Magbubah Essack, Aleksandar Radovanovic, Benoit Marchand, Salim Bougouffa, Andre Antunes, Marta Filipa Simoes, Feras F Lafi, Olaa A Motwalli, Ameerah Bokhari, Tariq Malas, Soha Al Amoudi, Ghofran Othum, Intikhab Allam, Katsuhiko Mineta, Xin Gao, Robert Hoehndorf, John A C Archer, Takashi Gojobori, Vladimir B Bajic
Microorganisms produce an enormous variety of chemical compounds. It is of general interest for microbiology and biotechnology researchers to have means to explore information about molecular and genetic basis of functioning of different microorganisms and their ability for bioproduction. To enable such exploration, we compiled 45 topic-specific knowledgebases (KBs) accessible through DESM portal ( The KBs contain information derived through text-mining of PubMed information and complemented by information data-mined from various other resources (e...
January 4, 2016: Nucleic Acids Research
Jiaping Lin, Xixi Cai, Mengru Tang, Shaoyun Wang
Marine algae have been becoming a popular research topic because of their biological implication. The algae peptide-based metal-chelating complex was investigated in this study. Schizochytrium sp. protein hydrolysate (SPH) possessing high Ca-binding capacity was prepared through stepwise enzymatic hydrolysis to a degree of hydrolysis of 22.46%. The nanocomposites of SPH chelated with calcium ions were fabricated in aqueous solution at pH 6 and 30 °C for 20 min, with the ratio of SPH to calcium 3:1 (w/w). The size distribution showed that the nanocomposite had compact structure with a radius of 68...
November 11, 2015: Journal of Agricultural and Food Chemistry
Anna Woodbury, Stephen Neal Soong, David Fishman, Paul S García
PURPOSE: This narrative review provides an overview of the complementary and alternative medicine (CAM) therapies that anesthesiologists and pain management practitioners commonly encounter along with recommendations for evaluation and implementation. SOURCE: A literature search of PubMed was performed using the comprehensive MeSH term, "Complementary Therapies OR Dietary Supplements", and a search was conducted of the various licensing organizations and books published on the topics of CAM and integrative medicine...
January 2016: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
Heerim Kang, Chang Hyung Lee, Jong Rhan Kim, Jung Yeon Kwon, Sang Gwon Seo, Jae Gab Han, Byung Gon Kim, Jong-Eun Kim, Ki Won Lee
Atopic dermatitis (AD) is a chronic and inflammatory skin disease that can place a significant burden on quality of life for patients. AD most frequently appears under the age of six and although its prevalence is increasing worldwide, therapeutic treatment options are limited. Chlorella vulgaris (CV) is a species of the freshwater green algae genus chlorella, and has been reported to modulate allergy-inducible factors when ingested. Here, we examined the effect of CV supplementation on AD-like symptoms in NC/Nga mice...
2015: International Journal of Molecular Sciences
Sara Nunes, Raquel Madureira, Débora Campos, Bruno Sarmento, Ana Maria Gomes, Manuela Pintado, Flávio Reis
Drug delivery systems, accompanied by nanoparticle technology, have recently emerged as prominent solutions to improve the pharmacokinetic properties, namely bioavailability, of therapeutic and nutraceutical agents. Solid lipid nanoparticles (SLNs) have received much attention from researchers due to their potential to protect or improve drug properties. SLNs have been reported to be an alternative system to traditional carriers, such as emulsions, liposomes and polymeric nanoparticles. Phenolic compounds are widespread in plant-derived foodstuffs and therefore abundant in our diet...
July 20, 2015: Critical Reviews in Food Science and Nutrition
Ana Laura Colín-González, Syed F Ali, Isaac Túnez, Abel Santamaría
Therapeutic approaches based on isolated compounds obtained from natural products to handle central and peripheral disorders involving oxidative stress and inflammation are more common nowadays. The validation of nutraceutics vs. pharmaceutics as tools to induce preventive and protective profiles in human health alterations is still far of complete acceptance, but the basis to start more solid experimental and clinical protocols with natural products has already begun. S-allyl cysteine (SAC) is a promising garlic-derived organosulfur compound exhibiting a considerable number of positive actions in cell models and living systems...
October 2015: Neurochemistry International
C D Hohmann, H Cramer, A Michalsen, C Kessler, N Steckhan, K Choi, G Dobos
BACKGROUND: Cardiovascular diseases are the world's leading cause of death. Prevention by nutrition is an easy and effective approach especially by advising foods with nutraceutic properties like high phenolic olive oil (HPOO). AIM: The aim of this review was to systematically access and meta-analyse the effects of HPOO on risk factors of the cardiovascular system and thusly to evaluate its use as a nutraceutical in prevention. DATA SYNTHESIS: Medline/PubMed, EMBase, the Cochrane Library, CAMbase and CAM-QUEST were searched through July 2013...
June 1, 2015: Phytomedicine: International Journal of Phytotherapy and Phytopharmacology
Cristina Vilaplana-Pérez, David Auñón, Libia A García-Flores, Angel Gil-Izquierdo
Hydroxytyrosol is one of the main phenolic components of olive oil. It is present in the fruit and leaf of the olive (Olea europaea L.). During the past decades, it has been well documented that this phenolic compound has health benefits and a protective action has been found in preclinical studies against several diseases. Here, we review its bioavailability in human beings and several assays showing significant results related with cardiovascular diseases, cancer, and acquired immunodeficiency syndrome (AIDS)...
2014: Frontiers in Nutrition
R R Watson, F Schönlau
Anthocyanins represent water-soluble flavonoid species, commonly found in higher plants, the richest plant source representing berries. While all anthocyanins present with antioxidant activity, the delphinidins represent the most potent antioxidant anthocyanin species owed to largest number of hydroxyl groups in the B-ring. The richest known natural source of delphinidins is the maqui berry (Aristotelia chilensis) from which an extract Delphinol®, standardized to 25% delphinidin, is commercially available...
April 2015: Minerva Cardioangiologica
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