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Topical nutraceuticals

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https://www.readbyqxmd.com/read/29141069/a-novel-multi-targeting-approach-to-treating-hair-loss-using-standardized-nutraceuticals
#1
Patricia K Farris, Nicole Rogers, Amy McMichael, Sophia Kogan
<p>Hair loss is a complicated problem that causes significant concern for those who are affected. Patients seeking medical treatment have limited options that include topical minoxidil and oral finasteride. While these treatments are backed by long term clinical use and research outcomes, many patients find topical minoxidil difficult to incorporate into their daily routine and some are concerned with the side effects associated with finasteride. In the office setting, patients may be treated with more invasive procedures such as platelet-rich plasma injections (PRP) and hair transplantation, treatments that often must be repeated and can lead to a costly investment...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29119922/polyphenols-anti-platelet-nutraceutical
#2
Valeria Ludovici, Jens Barthelmes, Matthias P Nägele, Andreas J Flammer, Isabella Sudano
BACKGROUND: Coronary artery disease (CAD) is a disease progressing over many years. Genetic factors, as well as the exposure to risk factors, are continuously leading to endothelial dysfunction, vascular alterations and, eventually, organ damage, major cardiovascular events and deaths. Oxidative stress, platelet hyperactivity and low-grade inflammation are important modulators in this context, contributing to plaque formation. Since platelet activation plays a critical role in the development and progression of atherothrombotic events, the inhibition of platelet hyperactivity may contribute to decreased atherothrombotic risk...
November 8, 2017: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/29096550/optimization-of-nutraceutical-coenzyme-q10-nanoemulsion-with-improved-skin-permeability-and-anti-wrinkle-efficiency
#3
Eman S El-Leithy, Amna M Makky, Abeer M Khattab, Doaa G Hussein
Coenzyme Q10 (CoQ10) is an insoluble, poorly permeable antioxidant with great biological value which acts as anti-aging and anti-wrinkle agent. To improve its permeability through topical application, the current study aimed at formulating oil/water (o/w) nanoemulsion (NE) as an efficient vehicle for delivering (CoQ10) through the skin barriers. The solubility of (CoQ10) was tested for various oils, surfactants (S), and co-surfactants (CoS). The NE region was determined by constructing pseudoternary phase diagrams...
November 2, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/29061510/in-vivo-comparisons-of-silver-nanoparticle-and-silver-ion-transport-after-intranasal-delivery-in-mice
#4
Jonathan L Falconer, David W Grainger
Silver nanoparticles (AgNPs) are widely available as consumer goods, and over-the-counter or nutraceutical products used for alleged therapeutic and antibacterial properties. Among these products, AgNP topical therapy is proposed for treating patients with upper airway bacterial rhinosinusitis. While silver ion release from AgNPs in biological systems is well known, limited investigations actually characterize this silver ion release and their subsequent biological effects distinct from delivered particulate metallic silver...
October 20, 2017: Journal of Controlled Release: Official Journal of the Controlled Release Society
https://www.readbyqxmd.com/read/28956697/annurca-apple-nutraceutical-formulation-enhances-keratin-expression-in-a-human-model-of-skin-and-promotes-hair-growth-and-tropism-in-a-randomized-clinical-trial
#5
Gian Carlo Tenore, Domenico Caruso, Giuseppe Buonomo, Maria D'Avino, Rita Santamaria, Carlo Irace, Marialuisa Piccolo, Maria Maisto, Ettore Novellino
Several pharmaceutical products have been formulated over the past decades for the treatment of male and female alopecia, and pattern baldness, but relatively few metadata on their efficacy have been published. For these reasons, the pharmaceutical and medical attention has recently focused on the discovery of new and safer remedies. Particularly, great interest has been attracted by oligomeric procyanidin bioactivity, able to promote hair epithelial cell growth as well as to induce the anagen phase. Specifically, the procyanidin B2, a dimeric derivative extracted from apples, has demonstrated to be one of the most effective and safest natural compounds in promoting hair growth, both in vitro and in humans by topical applications...
September 28, 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/28660193/abscisic-acid-a-novel-nutraceutical-for-glycemic-control
#6
REVIEW
Elena Zocchi, Raquel Hontecillas, Andrew Leber, Alexandra Einerhand, Adria Carbo, Santina Bruzzone, Nuria Tubau-Juni, Noah Philipson, Victoria Zoccoli-Rodriguez, Laura Sturla, Josep Bassaganya-Riera
Abscisic acid is naturally present in fruits and vegetables, and it plays an important role in managing glucose homeostasis in humans. According to the latest U.S. dietary survey, about 92% of the population might have a deficient intake of ABA due to their deficient intake of fruits and vegetables. This review summarizes the in vitro, preclinical, mechanistic, and human translational findings obtained over the past 15 years in the study of the role of ABA in glycemic control. In 2007, dietary ABA was first reported to ameliorate glucose tolerance and obesity-related inflammation in mice...
2017: Frontiers in Nutrition
https://www.readbyqxmd.com/read/28553090/anti-amyloid-aggregation-activity-of-novel-carotenoids-implications-for-alzheimer-s-drug-discovery
#7
Johant Lakey-Beitia, Deborah Doens, D Jagadeesh Kumar, Enrique Murillo, Patricia L Fernandez, K S Rao, Armando A Durant-Archibold
Alzheimer's disease (AD) is the leading cause of dementia, affecting approximately 33.5 million people worldwide. Aging is the main risk factor associated with AD. Drug discovery based on nutraceutical molecules for prevention and treatment of AD is a growing topic. In this sense, carotenoids are phytochemicals present mainly in fruits and vegetables with reported benefits for human health. In this research, the anti-amyloidogenic activity of three carotenoids, cryptocapsin, cryptocapsin-5,6-epoxide, and zeaxanthin, was assessed...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28434484/practical-aspects-in-the-management-of-statin-associated-muscle-symptoms-sams
#8
Ulrich Laufs, Krysztof J Filipiak, Ioanna Gouni-Berthold, Alberico L Catapano
BACKGROUND AND AIMS: Statin-associated muscle symptoms (SAMS) frequently cause statin non-adherence, switching and discontinuation, contributing to adverse cardiovascular (CV) outcomes. Therefore, the management of SAMS is key in the effective treatment of patients with cardiovascular disease (CVD), through achievement of maximum-tolerated statin dosing and other practical aspects. The aim of this article is to provide practical, focused advice for healthcare professionals on the management of patients with SAMS...
April 2017: Atherosclerosis. Supplements
https://www.readbyqxmd.com/read/28179978/mini-review-in-vitro-metabolic-engineering-for-biomanufacturing-of-high-value-products
#9
REVIEW
Weihua Guo, Jiayuan Sheng, Xueyang Feng
With the breakthroughs in biomolecular engineering and synthetic biology, many valuable biologically active compound and commodity chemicals have been successfully manufactured using cell-based approaches in the past decade. However, because of the high complexity of cell metabolism, the identification and optimization of rate-limiting metabolic pathways for improving the product yield is often difficult, which represents a significant and unavoidable barrier of traditional in vivo metabolic engineering. Recently, some in vitro engineering approaches were proposed as alternative strategies to solve this problem...
2017: Computational and Structural Biotechnology Journal
https://www.readbyqxmd.com/read/28025943/phenolic-compounds-as-nutraceuticals-or-functional-food-ingredients
#10
Cristina Caleja, Andreia Ribeiro, Maria Filomena Barreiro, Isabel C F R Ferreira
BACKGROUND: Nowadays, the functional foods represent one the most promising, interesting and innovative areas in the food industry. Various components are being added to foods in order to render them functional. METHODS: One example of these components are plant naturally occurring phenolic compounds, which are associated with a high antioxidant capacity and thus with benefits in relation to human health. RESULTS: However, despite the huge number of scientific studies and patents on this topic and their natural presence in foods, namely in the ones from plant origin, there are still few marketable products enriched with these compounds...
December 27, 2016: Current Pharmaceutical Design
https://www.readbyqxmd.com/read/27994480/combining-pain-therapy-with-lifestyle-the-role-of-personalized-nutrition-and-nutritional-supplements-according-to-the-simpar-feed-your-destiny-approach
#11
REVIEW
Manuela De Gregori, Carolina Muscoli, Michael E Schatman, Tiziana Stallone, Fabio Intelligente, Mariangela Rondanelli, Francesco Franceschi, Laura Isabel Arranz, Silvia Lorente-Cebrián, Maurizio Salamone, Sara Ilari, Inna Belfer, Massimo Allegri
Recently, attention to the lifestyle of patients has been rapidly increasing in the field of pain therapy, particularly with regard to the role of nutrition in pain development and its management. In this review, we summarize the latest findings on the role of nutrition and nutraceuticals, microbiome, obesity, soy, omega-3 fatty acids, and curcumin supplementation as key elements in modulating the efficacy of analgesic treatments, including opioids. These main topics were addressed during the first edition of the Study In Multidisciplinary Pain Research workshop: "FYD (Feed Your Destiny): Fighting Pain", held on April 7, 2016, in Rome, Italy, which was sponsored by a grant from the Italian Ministry of Instruction on "Nutraceuticals and Innovative Pharmacology"...
2016: Journal of Pain Research
https://www.readbyqxmd.com/read/27773280/ultrasound-assisted-extraction-of-food-and-natural-products-mechanisms-techniques-combinations-protocols-and-applications-a-review
#12
Farid Chemat, Natacha Rombaut, Anne-Gaëlle Sicaire, Alice Meullemiestre, Anne-Sylvie Fabiano-Tixier, Maryline Abert-Vian
This review presents a complete picture of current knowledge on ultrasound-assisted extraction (UAE) in food ingredients and products, nutraceutics, cosmetic, pharmaceutical and bioenergy applications. It provides the necessary theoretical background and some details about extraction by ultrasound, the techniques and their combinations, the mechanisms (fragmentation, erosion, capillarity, detexturation, and sonoporation), applications from laboratory to industry, security, and environmental impacts. In addition, the ultrasound extraction procedures and the important parameters influencing its performance are also included, together with the advantages and the drawbacks of each UAE techniques...
January 2017: Ultrasonics Sonochemistry
https://www.readbyqxmd.com/read/27747904/improvement-of-skin-condition-by-oral-administration-of-collagen-hydrolysates-in-chronologically-aged-mice
#13
Zhenbin Wang, Qing Wang, Lin Wang, Weidong Xu, Yuanqing He, Yunliang Li, Song He, Haile Ma
BACKGROUND: Collagen hydrolysates (CHs) have been demonstrated to have positive effects on skin photoaging by topical application or oral ingestion. However, there has been little research on their influence on skin chronological aging. In this study, 9-month-old female ICR mice were given normal AIN-93M diets containing CHs (2.5, 5 and 10% w/w) from Nile tilapia scale. RESULTS: After 6 months, the collagen content and antioxidant enzyme (superoxide dismutase and glutathione peroxidase) activities increased significantly (P < 0...
October 17, 2016: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27618998/local-knowledge-held-by-farmers-in-eastern-tyrol-austria-about-the-use-of-plants-to-maintain-and-improve-animal-health-and-welfare
#14
Christian R Vogl, Brigitte Vogl-Lukasser, Michael Walkenhorst
BACKGROUND: The sustainable management of animal health and welfare is of increasing importance to consumers and a key topic in the organic farming movement. Few systematic studies have been undertaken investigating farmers' local knowledge related to this issue. Ethnoveterinary medicine (EVM) is a discipline focusing on local knowledge and folk methods in veterinary medicine, however most ethnoveterinarian studies primarily address the treatment of animal diseases. Very few studies have explored prophylactic methods...
September 12, 2016: Journal of Ethnobiology and Ethnomedicine
https://www.readbyqxmd.com/read/27340792/nanospray-drying-as-a-novel-tool-to-improve-technological-properties-of-soy-isoflavone-extracts
#15
Pasquale Del Gaudio, Francesca Sansone, Teresa Mencherini, Felicetta De Cicco, Paola Russo, Rita Patrizia Aquino
Pharmacological evidences have correlated a low incidence of osteoporosis, breast cancer, cardiovascular disease, and colon cancer in Asian populations, high consumers of soya, to the properties of soy isoflavones, more specifically to daidzein and genistein. However, in spite of the potent biological activity, their poor water solubility has a strong negative effect on bioavailability. In this study, an innovative technique, nano spray drying, was used to obtain nanoparticles loaded with a soybean dry extract while carboxymethyl cellulose was used as the excipient...
March 2017: Planta Medica
https://www.readbyqxmd.com/read/27312122/zeaxanthin-based-dietary-supplement-and-topical-serum-improve-hydration-and-reduce-wrinkle-count-in-female-subjects
#16
RANDOMIZED CONTROLLED TRIAL
Steve Schwartz, Emily Frank, Dennis Gierhart, Paula Simpson, Robert Frumento
BACKGROUND: Dietary modification, through supplementation and elimination diets, has become an area of interest to help slow skin aging, reduce symptom severity or prevent reoccurrence of certain dermatologic conditions [Clinical Dermatology vol. 31 (2013) 677-700]. Free radical components (reactive oxygen species or ROS) or lipid peroxide (LPO) is involved in the pathogenesis and progression of accelerated skin aging when prolonged oxidative stress occurs. The use of antioxidant-related therapies such as nutraceuticals is of particular interest in restoring skin homeostasis...
December 2016: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/27103781/omega-3-fatty-acid-supplementation-improves-dry-eye-symptoms-in-patients-with-glaucoma-results-of-a-prospective-multicenter-study
#17
Jesús Tellez-Vazquez
PURPOSE: The purpose of this study is to assess the effectiveness and tolerability of a dietary supplement with a combination of omega-3 fatty acids and antioxidants on dry eye symptoms caused by chronic instillation of antihypertensive eye drops in patients with glaucoma. PATIENTS AND METHODS: A total of 1,255 patients with glaucoma and dry eye symptoms related to antiglaucoma topical medication participated in an open-label, uncontrolled, prospective, and multicenter study and were instructed to take three capsules a day of the nutraceutical formulation (Brudypio(®) 1...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/26996462/proteomics-for-exploiting-diversity-of-lupin-seed-storage-proteins-and-their-use-as-nutraceuticals-for-health-and-welfare
#18
Francisco Cabello-Hurtado, Jean Keller, José Ley, Rosa Sanchez-Lucas, Jesús V Jorrín-Novo, Abdelkader Aïnouche
UNLABELLED: Lupins have a variety of both traditional and modern uses. In the last decade, reports assessing the benefits of lupin seed proteins have proliferated and, nowadays, the pharmaceutical industry is interested in lupin proteins for human health. Modern genomics and proteomics have hugely contributed to describing the diversity of lupin storage genes and, above all, proteins. Most of these studies have been centered on few edible lupin species. However, Lupinus genus comprises hundreds of species spread throughout the Old and New Worlds, and these resources have been scarcely explored and exploited...
June 30, 2016: Journal of Proteomics
https://www.readbyqxmd.com/read/26840367/a-pharmacological-perspective-on-the-use-of-brazilian-red-propolis-and-its-isolated-compounds-against-human-diseases
#19
REVIEW
Irlan Almeida Freires, Severino Matias de Alencar, Pedro Luiz Rosalen
Propolis is a complex resinous mixture collected by bees, with high medicinal, historical and economic value. The nutraceutical and pharmacological benefits of propolis have been extensively explored in several fields of medicine as an important resource for prevention and treatment of oral and systemic diseases. A relatively new type of propolis, named red propolis (in Brazil, Brazilian Red Propolis - BRP), has been arousing attention for the promising pharmacological properties of some of its isolated compounds (vestitol, neovestitol, quercetin, medicarpin, formononetin, etc)...
March 3, 2016: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/26635610/effects-of-topical-fucosyl-lactose-a-milk-oligosaccharide-on-dry-eye-model-an-example-of-nutraceutical-candidate
#20
Claudio Bucolo, Maria Musumeci, Salvatore Salomone, Giovanni Luca Romano, Gian Marco Leggio, Caterina Gagliano, Michele Reibaldi, Teresio Avitabile, Maurizio G Uva, Salvatore Musumeci, Filippo Drago
PURPOSE: Colostrum has been proposed to treat severe dryness and problematic eye lesions showing a beneficial effect. The aim of the study was to investigate the effect of 2-fucosyl-lactose, a natural sugar present in the human colostrum, in an experimental dry eye. METHODS: Dry eye was induced in adult male New Zealand albino rabbits by topical administration of 1% atropine. Tear volume (Schirmer's test), tear film breakup time (TBUT), corneal staining and tear osmolarity were assessed...
2015: Frontiers in Pharmacology
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