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Nutriceuticals

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https://www.readbyqxmd.com/read/29109370/olive-olea-europaea-l-biophenols-a-nutriceutical-against-oxidative-stress-in-sh-sy5y-cells
#1
Syed Haris Omar, Philip G Kerr, Christopher J Scott, Adam S Hamlin, Hassan K Obied
Plant biophenols have been shown to be effective in the modulation of Alzheimer's disease (AD) pathology resulting from free radical-induced oxidative stress and imbalance of the redox chemistry of transition metal ions (e.g., iron and copper). On the basis of earlier reported pharmacological activities, olive biophenols would also be expected to have anti-Alzheimer's activity. In the present study, the antioxidant activity of individual olive biophenols (viz. caffeic acid, hydroxytyrosol, oleuropein, verbascoside, quercetin, rutin and luteolin) were evaluated using superoxide radical scavenging activity (SOR), hydrogen peroxide (H₂O₂) scavenging activity, and ferric reducing ability of plasma (FRAP) assays...
October 29, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29074616/resveratrol-a-novel-type-of-topoisomerase-ii-inhibitor
#2
Joyce H Lee, Timothy J Wendorff, James M Berger
Resveratrol, a polyphenol found in various plant sources, has gained attention as a possible agent responsible for the purported health benefits of certain foods, such as red wine. Despite annual multi-million dollar market sales as a nutriceutical, there is little consensus about the physiological roles of resveratrol. One suggested molecular target of resveratrol is eukaryotic topoisomerase II (topo II), an enzyme essential for chromosome segregation and DNA supercoiling homeostasis. Interestingly, resveratrol is chemically similar to ICRF-187, a clinically-approved chemotherapeutic that stabilizes an ATP-dependent dimerization interface in topo II to block enzyme activity...
October 26, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28748085/fermentation-induced-changes-in-volatile-components-of-african-oil-bean-pentaclethra-macrophylla-benth-seeds
#3
Reginald C Ohiri, Essien E Bassey
Fermented African oil bean (Pentaclethra macrophylla Benth) seed also referred to as "Ugba" is a known delicacy, mainly consumed by Africans. Human migration has also led to the introduction of this delicacy into most European and American countries. This study shows the changes in volatile components of African oil bean (P. macrophylla Benth) seed at different stages of fermentation. A quantity of 0.3 kg each of dehulled and sliced raw sample and cooked unfermented sample were separately ground, while 2 and 4 days fermented samples obtained by inoculating 0...
July 2017: Food Science & Nutrition
https://www.readbyqxmd.com/read/28367715/two-armed-activation-of-bone-mineral-deposition-by-the-flavones-baicalin-and-baicalein-encapsulated-in-polyphosphate-microparticles
#4
Xiao-Hong Wang, Yue-Wei Guo, Emad Tolba, Maria Kokkinopoulou, Matthias Wiens, Heinz C Schröder, Werner E G Müller
In this study, we investigated the effect of the two flavonoids, baicalin (baicalein 7-O-[Formula: see text]- d-glucuronic acid) and its aglycone, baicalein (5,6,7-trihydroxyflavone), after encapsulation into amorphous calcium polyphosphate (Ca-polyP) microparticles on mineralization of primary human osteoblasts (phOSB). Both flavonoids, which come from root extracts of Scutellaria baicalensis Georgi, are used in Traditional Chinese Medicine, and are nontoxic in cells up to a concentration of 3[Formula: see text][Formula: see text]g/ml...
2017: American Journal of Chinese Medicine
https://www.readbyqxmd.com/read/27934649/safety-and-effectiveness-of-arginine-in-adults
#5
REVIEW
Catherine J McNeal, Cynthia J Meininger, Deepika Reddy, Colin D Wilborn, Guoyao Wu
l-Arginine (Arg) appears to have a beneficial effect on the regulation of nutrient metabolism to enhance lean tissue deposition and on insulin resistance in humans. The observed safe level for oral administration of Arg is ∼20 g/d, but higher levels have been tested in short-term studies without serious adverse effects; however, more data are needed in both animal models and humans to fully evaluate safety as well as efficacy. The primary objective of this review is to summarize the current knowledge of the safety, pharmacokinetics, and effectiveness of oral Arg in adults...
December 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27910756/fatty-acid-composition-of-different-collections-of-coprinoid-mushrooms-agaricomycetes-and-their-nutritional-and-medicinal-values
#6
Susanna M Badalyan
Qualitative and quantitative analyses of the free fatty acid (FA) composition of ethanol extracts obtained from mycelia of 30 genetically identified strains of 18 species of coprinoid mushrooms (CMs) or coprini belonging to clades Coprinellus (C. bisporus, C. curtus, C. disseminatus, C. domesticus, C. ellisii, C.flocculosus, C. micaceus, C. aff radians I, C. aff radians II, C. aff radians III, C. xanthothrix, Coprinellus sp. 4), Coprinopsis (C. cinerea, C. cothurnata, C. gonophylla, C. lagopides, C. maysoidispora, C...
2016: International Journal of Medicinal Mushrooms
https://www.readbyqxmd.com/read/27608429/oral-administration-of-an-aqueous-extract-from-the-oyster-mushroom-pleurotus-ostreatus-enhances-the-immunonutritional-recovery-of-malnourished-mice
#7
Gabriel Llauradó, Humberto J Morris, Yamila Lebeque, Gleymis Venet, Onel Fong, Jane Marcos, Roberto Fontaine, Paul Cos, Rosa C Bermúdez
Mushroom nutriceutical components have lately attracted interest for developing immunonutritional support. However, there is relatively little information pertaining to the use of mushroom preparations for modulating the metabolic and immunological disorders associated to malnutrition. This study was aimed to evaluate the effects of oral administration of an aqueous extract (CW-P) from Pleurotus ostreatus on the recovery of biochemical and immunological functions of malnourished mice. 8-week old female BALB/c mice were starved for 3days and then refed with commercial diet supplemented with or without CW-P (100mg/kg) for 8days...
October 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27465270/protein-peptide-nutritional-material-prepared-from-surimi-wash-water-using-immobilized-chymotrypsin-trypsin
#8
Hao-Chen Ding, Dong-Fang Li, Xiao-Yi Wei, Yao-Wen Huang, Shuai Cui, Hu-Jun Xie, Tao Zhou
BACKGROUND: In the production process of surimi, large quantities of wastewater are produced. Thus it would be interesting to develop an efficient protocol for the recovery of protein from hairtail surimi wash-water. RESULTS: A technique involving the use of immobilized chymotrypsin-trypsin (I-CT) was developed, providing a practical method for the preparation of protein-peptide nutritional material (PPNM). Under optimized reaction conditions, the recovery rate of nitrogen of surimi wash-water was measured as 98...
April 2017: Journal of the Science of Food and Agriculture
https://www.readbyqxmd.com/read/27358648/possible-inhibition-of-hydroxy-methyl-glutaryl-coa-reductase-activity-by-nicotinic-acid-and-ergosterol-as-targeting-for-hypocholesterolemic-action
#9
Said S Moselhy, I H Kamal, Taha A Kumosani, E A Huwait
OBJECTIVE: Coronary artery diseases including atherosclerosis is considered as commonest problem worldwide. Ergosterols are the main components of vegetable oils and nuts. The objective of this study was to evaluate the potential hypoplipidemic and hypocholesterolemic effects of ergosterol in combination with niacin in rats fed high fat diet (HFD). METHODS: Eighty male albino rats were included in this study divided into two main groups: Group I: Normal rats fed standard diet treated with either niacin (8...
March 2016: African Health Sciences
https://www.readbyqxmd.com/read/27017022/complementary-and-integrative-approaches-for-pediatric-headache
#10
REVIEW
Sita Kedia
In this article, the use of complementary and integrative medicine for the management of pediatric headache is reviewed. Despite limited numbers of studies for pediatric headaches, children and families seek these services. Integrative medicine focuses on treating the whole person, integrating conventional medicine with mind-body-spirit methods. Nutriceuticals include dietary supplements in the form of vitamins (vitamin D), minerals (magnesium), coenzyme Q, butterbur, and melatonin. Acupuncture, stimulation, physical therapy and Transcutaneous Electrical Nerve Stimulations (TENS) or Transcranial Magnetic Stimulation (TMS) may also be useful in selected patients...
February 2016: Seminars in Pediatric Neurology
https://www.readbyqxmd.com/read/26584644/redox-interventions-to-increase-exercise-performance
#11
REVIEW
Michael B Reid
Skeletal muscle continually produces reactive oxygen species (ROS) and nitric oxide (NO) derivatives. Both oxidant cascades have complex effects on muscle contraction, metabolic function and tissue perfusion. Strenuous exercise increases oxidant production by muscle, limiting performance during endurance exercise tasks. Conversely, redox interventions that modulate ROS or NO activity have the potential to improve performance. Antioxidants have long been known to buffer ROS activity and lessen oxidative perturbations during exercise...
September 15, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/26395368/the-andrologist-s-contribution-to-a-better-life-for-ageing-men-part-2
#12
F Comhaire, A Mahmoud
The long-term intake of a judiciously composed nutriceutical containing low-dose vitamins, antioxidants, minerals and particular herbal preparations seems justified for older persons who take medication, or who consume an unbalanced diet, or who are exposed to environmental toxins. Recent reports suggest these nutriceuticals may delay age-related diseases and the occurrence of cancer, and reduce mortality in apparently healthy ageing men. Food supplementation with a nutriceutical that was formulated particularly for ageing men should result in an increase of at least one quality-adjusted life year and may lower the financial and social burden of disease in elderly people...
February 2016: Andrologia
https://www.readbyqxmd.com/read/26069548/articular-cartilage-injury-in-athletes
#13
REVIEW
Timothy R McAdams, Kai Mithoefer, Jason M Scopp, Bert R Mandelbaum
Articular cartilage lesions in the athletic population are observed with increasing frequency and, due to limited intrinsic healing capacity, can lead to progressive pain and functional limitation over time. If left untreated, isolated cartilage lesions can lead to progressive chondropenia or global cartilage loss over time. A chondropenia curve is described to help predict the outcome of cartilage injury based on different lesion and patient characteristics. Nutriceuticals and chondroprotective agents are being investigated as tools to slow the development of chondropenia...
July 2010: Cartilage
https://www.readbyqxmd.com/read/25938485/investigate-the-binding-of-catechins-to-trypsin-using-docking-and-molecular-dynamics-simulation
#14
Fengchao Cui, Kecheng Yang, Yunqi Li
To explore the inhibitory mechanism of catechins for digestive enzymes, we investigated the binding mode of catechins to a typical digestive enzyme-trypsin and analyzed the structure-activity relationship of catechins, using an integration of molecular docking, molecular dynamics simulation and binding free energy calculation. We found that catechins with different structures bound to a conservative pocket S1 of trypsin, which is comprised of residues 189-195, 214-220 and 225-228. In the trypsin-catechin complexes, Asp189 by forming strong hydrogen bonding, and Gln192, Trp215 and Gly216 through hydrophobic interactions, all significantly contribute to the binding of catechins...
2015: PloS One
https://www.readbyqxmd.com/read/25668332/hormones-herbal-preparations-and-nutriceuticals-for-a-better-life-after-the-menopause-part-ii
#15
REVIEW
F H Comhaire, H T Depypere
Long-term estrogen replacement therapy with estrogen has benefits for many postmenopausal women. However, some women prefer non-steroidal substitution with herbal preparations. The effectivity against vasomotor symptoms has been evidenced for the extracts of pine bark, of linseed and of Lepidium meyenii (Maca), whereas there is controversy about the effectiveness of genistein-rich soy extract. The extracts of cruciferous vegetables such as Broccoli and of linseed induce changes in the metabolism of estrogens, and antioxidants may reverse altered epigenetic DNA methylation, possibly reducing the risk of breast cancer or its recurrence...
June 2015: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/25668235/hormones-herbal-preparations-and-nutriceuticals-for-a-better-life-after-the-menopause-part-i
#16
REVIEW
F H Comhaire, H T Depypere
In developed countries, women spend more than one-third of their life in the menopause and at least half of them experience vasomotor symptoms that impair their normal function and well-being. Long-term estrogen replacement therapy (HRT) with estrogen can suppress typical menopausal symptoms and prevents osteoporosis. When estrogen-only HRT is started within 10 years after the menopause, the prevalence of cardiovascular disease is reduced, mortality is lower, and the risk of breast cancer is not significantly increased...
June 2015: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/25170991/a-nutritional-toxicological-assessment-of-antarctic-krill-oil-versus-fish-oil-dietary-supplements
#17
COMPARATIVE STUDY
Susan M Bengtson Nash, Martin Schlabach, Peter D Nichols
Fish oil dietary supplements and complementary medicines are pitched to play a role of increasing strategic importance in meeting daily requirements of essential nutrients, such as long-chain (≥ C20, LC) omega-3 polyunsaturated fatty acids and vitamin D. Recently a new product category, derived from Antarctic krill, has been launched on the omega-3 nutriceutical market. Antarctic krill oil is marketed as demonstrating a greater ease of absorption due to higher phospholipid content, as being sourced through sustainable fisheries and being free of toxins and pollutants; however, limited data is available on the latter component...
August 28, 2014: Nutrients
https://www.readbyqxmd.com/read/24905859/emerging-role-of-advanced-glycation-end-products-ages-in-the-pathobiology-of-eye-diseases
#18
REVIEW
Stylianos A Kandarakis, Christina Piperi, Fotis Topouzis, Athanasios G Papavassiliou
Advanced glycation end products (AGEs) have been implicated in vision loss associated with macula degeneration, cataract formation, diabetic retinopathy and glaucoma. This pathogenic potential is mainly attributed to their accumulation in ocular tissues where they mediate aberrant crosslinking of extracellular matrix proteins and disruption of endothelial junctional complexes that affects cell permeability, mediates angiogenesis and breakdown of the inner blood-retinal barrier. Furthermore, AGEs severely affect cellular metabolism by disrupting ATP production, enhancing oxidative stress and modulating gene expression of anti-angiogenic and anti-inflammatory genes...
September 2014: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/24851176/improvement-of-semen-quality-in-holstein-bulls-during-heat-stress-by-dietary-supplementation-of-omega-3-fatty-acids
#19
Hamid Gholami, Mohamad Chamani, Armin Towhidi, Mohammad Hashem Fazeli
BACKGROUND: Long-chain polyunsaturated fatty acids (PUFAs) of the omega-3 family are important for sperm membrane integrity, sperm motility and viability. There are evidences to suggest that dietary supplementation with omega-3 fatty acids affects reproduction in men and males of different animal species. Therefore, the aim of current study was to investigate changes in the quality parameters of Holstein bull semen during heat stress and the effect of feeding a source of omega-3 fatty acids during this period...
January 2011: International Journal of Fertility & Sterility
https://www.readbyqxmd.com/read/24779775/pro-oxidative-and-antioxidative-controls-and-signaling-modification-of-polyphenolic-phytochemicals-contribution-to-health-promotion-and-disease-prevention
#20
REVIEW
Kai On Chu, Sun-On Chan, Chi Pui Pang, Chi Chiu Wang
Polyphenolic phytochemicals (PPs) have been extensively studied as potential nutriceuticals for maintenance of health and treatment of cancer, inflammation, and neurodegeneration. However, the reported beneficial outcomes are inconsistent. The biological activities of PPs have been attributed to their pro-oxidative and antioxidative actions and effects on signaling mechanisms and epigenomic modifications. These diversified properties were described or postulated on the basis of a variety of experimental studies using cell culture and animal models, even though most have not been replicated and results are not validated...
May 7, 2014: Journal of Agricultural and Food Chemistry
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