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https://www.readbyqxmd.com/read/28456080/radiosynthesis-and-biological-evaluation-of-n-2-18-f-fluoropropionyl-3-4-dihydroxy-l-phenylalanine-as-a-pet-tracer-for-oncologic-imaging
#1
Caihua Tang, Dahong Nie, Ganghua Tang, Siyuan Gao, Shaoyu Liu, Fuhua Wen, Xiaolan Tang
INTRODUCTION: Several (11)C and (18)F labeled 3,4-dihydroxy-l-phenylalanine (l-DOPA) analogues have been used for neurologic and oncologic diseases, especially for brain tumors and neuroendocrine tumors PET imaging. However, (18)F-labeled N-substituted l-DOPA analogues have not been reported so far. In the current study, radiosynthesis and biological evaluation of a new (18)F-labeled l-DOPA analogue, N-(2-[(18)F]fluoropropionyl)-3,4-dihydroxy-l-phenylalanine ([(18)F]FPDOPA) for tumor PET imaging are performed...
April 7, 2017: Nuclear Medicine and Biology
https://www.readbyqxmd.com/read/28433557/early-changes-of-left-ventricular-filling-pattern-after-reperfused-st-elevation-myocardial-infarction-and-doxycycline-therapy-insights-from-the-tiptop-trial
#2
Giampaolo Cerisano, Piergiovanni Buonamici, Guido Parodi, Alberto Santini, Guia Moschi, Renato Valenti, Angela Migliorini, Paolo Colonna, Benedetta Bellandi, Anna Maria Gori, David Antoniucci
AIM: Metalloproteinases inhibition by doxycycline reduces cardiac protein degradation at extracellular and intracellular level in the experimental model ischemia/reperfusion injury. Since both extracellular cardiac matrix and titin filaments inside the cardiomyocyte are responsible for the myocardial stiffness, we hypothesized that doxycycline could favorably act on left ventricular (LV) filling pressures in patients after reperfused acute ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: Seventy-three of 110 patients of the TIPTOP trial underwent a 2D-Echo-Doppler on admission, and at pre-discharge and at 6-month after a primary PCI for STEMI and LV dysfunction...
April 7, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28391588/exploring-multilevel-factors-for-family-engagement-in-home-visiting-across-two-national-models
#3
Amanda D Latimore, Lori Burrell, Sarah Crowne, Kristen Ojo, Fallon Cluxton-Keller, Sunday Gustin, Lakota Kruse, Daniela Hellman, Lenore Scott, Annette Riordan, Anne Duggan
The associations of family, home visitor and site characteristics with family engagement within the first 6 months were examined. The variation in family engagement was also explored. Home visiting program participants were drawn from 21 Healthy Families America sites (1707 families) and 9 Nurse-Family Partnership sites (650 families) in New Jersey. Three-level nested generalized linear mixed models assessed the associations of family, home visitor and site characteristics with family receipt of a high dose of services in the first 6 months of enrollment...
April 8, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28383313/is-there-a-trade-off-between-quality-and-profitability-in-united-states-nursing-homes
#4
Tyler Godby, Sarah Saldanha, Jazmine Valle, David P Paul, Alberto Coustasse
Nursing home residents across the United States rely on quality care and effective services. Nursing homes provide skilled nurses and nursing aides who can provide services 24 hours a day for individuals who could not perform these tasks for themselves. Not-for-profit (NFP) versus for-profit (FP) nursing homes have been examined for utilization and efficacy; however, it has been shown that NFP nursing homes generally offer higher quality care and generate greater profit margins compared with FP nursing homes...
April 2017: Health Care Manager
https://www.readbyqxmd.com/read/28371913/consumers-responses-to-health-claims-in-the-context-of-other-on-pack-nutrition-information-a-systematic-review
#5
Zenobia Talati, Simone Pettigrew, Bruce Neal, Helen Dixon, Clare Hughes, Bridget Kelly, Caroline Miller
The presence of health claims on food packaging can positively bias consumers' evaluations of foods. This review examined whether cognitive biases endure when other sources of nutrition information [the nutrition facts panel (NFP) and front-of-pack labels] appear on-pack with health claims. The following databases were searched: Web of Science, Ovid, Google Scholar, ScienceDirect, Scopus, ProQuest, and Wiley Online Library. The search terms ("health claim*" OR "nutri* claim") AND ("food label*" OR "front of pack") were used to identify studies...
March 21, 2017: Nutrition Reviews
https://www.readbyqxmd.com/read/28349048/use-of-natural-family-planning-nfp-and-its-effect-on-couple-relationships-and-sexual-satisfaction-a-multi-country-survey-of-nfp-users-from-us-and-europe
#6
Matthias Unseld, Elisabeth Rötzer, Roman Weigl, Eva K Masel, Michael D Manhart
PURPOSE: Birth control is a persistent global health concern. Natural family planning (NFP) comprises methods to achieve or avoid pregnancy independent of mechanical or pharmacological intervention. The sympto-thermal method (STM) of NFP employs daily observation of cervical fluids and measurement of basal body temperature. This multi-country study was undertaken to describe the characteristics of STM users, understand their perceptions of NFP, and its perceived impact on relationships...
2017: Frontiers in Public Health
https://www.readbyqxmd.com/read/28326701/-morphological-features-and-analysis-of-the-nerve-fibers-in-the-periodontal-ligament-of-dogs
#7
Zeng Xiaohua, Cai Qiaoling, Gong Ping
OBJECTIVE: To identify the properties of nerve fibers of dogs by immunohistochemical staining method. METHODS: Intact bone blocks above the inferior alveolar nerve canal were cut from the medial of the second premolar to the distal of the third premolar of healthy adult Beagle dogs of 18 months, embedded to make hard tissue sections, stained with S100 and neurofilament protein (NFP) antibodies, and finally observed the nerve distribution under the microscope. RESULTS: The distribution of S100 positive tissue in the periodontal ligament of dogs showed the following patterns: bundles of densely gathered rings with different diameters, filaments accompanied by lumens, free endings and deep-dyeing oval lamellasome...
October 1, 2016: Hua Xi Kou Qiang Yi Xue za Zhi, Huaxi Kouqiang Yixue Zazhi, West China Journal of Stomatology
https://www.readbyqxmd.com/read/28286177/screening-for-novel-central-nervous-system-biomarkers-in-veterans-with-gulf-war-illness
#8
Mohamed B Abou-Donia, Lisa A Conboy, Efi Kokkotou, Eric Jacobson, Eman M Elmasry, Passent Elkafrawy, Megan Neely, Cameron R 'Dale' Bass, Kimberly Sullivan
Gulf War illness (GWI) is primarily diagnosed by symptom report; objective biomarkers are needed that distinguish those with GWI. Prior chemical exposures during deployment have been associated in epidemiologic studies with altered central nervous system functioning in veterans with GWI. Previous studies from our group have demonstrated the presence of autoantibodies to essential neuronal and glial proteins in patients with brain injury and autoantibodies have been identified as candidate objective markers that may distinguish GWI...
March 9, 2017: Neurotoxicology and Teratology
https://www.readbyqxmd.com/read/28280740/nfp-an-r-package-for-characterizing-and-comparing-of-annotated-biological-networks
#9
Yang Cao, Wenjian Xu, Chao Niu, Xiaochen Bo, Fei Li
Large amounts of various biological networks exist for representing different types of interaction data, such as genetic, metabolic, gene regulatory, and protein-protein relationships. Recent approaches on biological network study are based on different mathematical concepts. It is necessary to construct a uniform framework to judge the functionality of biological networks. We recently introduced a knowledge-based computational framework that reliably characterized biological networks in system level. The method worked by making systematic comparisons to a set of well-studied "basic networks," measuring both the functional and topological similarities...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28236560/the-dynamics-of-contract-plasma-fractionation
#10
REVIEW
Albert Farrugia, Daniela Scaramuccia
Plasma Derived Medicinal Products (PMDPs) are an essential component of the modern therapeutic armamentarium. They are differentiated from most other medicines in several ways, particularly the unique nature of the raw material used for their manufacture. Human plasma has been fractionated to PDMPs for the past 75 years, and the economics of manufacturing requires currently that as many products are harvested from each litre as is feasible and reflective of clinical needs. PDMPs may be purchased on the open market from the various commercial and not-for-profit (NFP) manufacturers...
March 2017: Biologicals: Journal of the International Association of Biological Standardization
https://www.readbyqxmd.com/read/28223994/enhanced-grain-iron-levels-in-rice-expressing-an-iron-regulated-metal-transporter-nicotianamine-synthase-and-ferritin-gene-cassette
#11
Kulaporn Boonyaves, Ting-Ying Wu, Wilhelm Gruissem, Navreet K Bhullar
Micronutrient malnutrition is widespread, especially in poor populations across the globe, and iron deficiency anemia is one of the most prevalent forms of micronutrient deficiencies. Iron deficiency anemia has severe consequences for human health, working ability, and quality of life. Several interventions including iron supplementation and food fortification have been attempted and met with varied degrees of success. Rice, which is a staple food for over half of the world's population, is an important target crop for iron biofortification...
2017: Frontiers in Plant Science
https://www.readbyqxmd.com/read/28221809/accommodating-high-transformation-strains-in-battery-electrodes-via-the-formation-of-nanoscale-intermediate-phases-operando-investigation-of-olivine-nafepo4
#12
Kai Xiang, Wenting Xing, Dorthe B Ravnsbæk, Liang Hong, Ming Tang, Zheng Li, Kamila M Wiaderek, Olaf J Borkiewicz, Karena W Chapman, Peter J Chupas, Yet-Ming Chiang
Virtually all intercalation compounds exhibit significant changes in unit cell volume as the working ion concentration varies. NaxFePO4 (0 < x < 1, NFP) olivine, of interest as a cathode for sodium-ion batteries, is a model for topotactic, high-strain systems as it exhibits one of the largest discontinuous volume changes (∼17% by volume) during its first-order transition between two otherwise isostructural phases. Using synchrotron radiation powder X-ray diffraction (PXD) and pair distribution function (PDF) analysis, we discover a new strain-accommodation mechanism wherein a third, amorphous phase forms to buffer the large lattice mismatch between primary phases...
March 8, 2017: Nano Letters
https://www.readbyqxmd.com/read/28115186/red-fluorescence-of-dental-plaque-in-children-a-cross-sectional-study
#13
Catherine M C Volgenant, Egija Zaura, Bernd W Brandt, Mark J Buijs, Marisol Tellez, Gayatri Malik, Amid I Ismail, Jacob M Ten Cate, Monique H van der Veen
OBJECTIVES: The relation between the presence of red fluorescent plaque and the caries status in children was studied. In addition, the microbial composition of dental plaque from sites with red fluorescent plaque (RFP) and from sites with no red fluorescent plaque (NFP) was assessed. METHODS: Fluorescence photographs were taken from fifty children (6-14 years old) with overnight plaque. Full-mouth caries scores (ICDAS II) were obtained. The composition of a saliva sample and two plaque samples (RFP and NFP) was assessed using 16S rDNA sequencing...
January 20, 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28105544/status-of-birth-outcomes-in-clients-of-the-nurse-family-partnership
#14
William Thorland, Dustin W Currie
Background The Nurse-Family Partnership (NFP) is a national, evidence-based home visiting program currently serving over 30,000 first-time, low-income mothers. Prior to public implementation, three foundational randomized controlled trials demonstrated program effectiveness in achieving beneficial birth, child development, and maternal life-course outcomes. This study describes birth outcomes of contemporary NFP clients compared to a reference cohort, providing the first evidence of program effect on a nation-wide basis during scale-up...
January 19, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28092061/status-of-breastfeeding-and-child-immunization-outcomes-in-clients-of-the-nurse-family-partnership
#15
William Thorland, Dustin Currie, Emily R Wiegand, Joe Walsh, Nick Mader
Background The Nurse-Family Partnership (NFP) is a home visiting program serving first-time, low-income mothers, with an area of focus on healthy early childhood development. Previous foundational trials of program effect on breastfeeding and immunizations have shown a mix of neutral and positive results. The present evaluation investigates these effects following program scale-up, using a large contemporary cohort of clients. Methods Nurse-Family Partnership client breastfeeding and immunization status were compared to National Survey of Children's Health data and National Immunization Survey data, respectively...
January 13, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28079576/mixed-gangliocytoma-pituitary-adenoma-insights-on-the-pathogenesis-of-a-rare-sellar-tumor
#16
M Beatriz S Lopes, Emily Sloan, Julie Polder
Gangliocytomas originating in the sellar region are rare; most are tumors composed of gangliocytic and pituitary adenomatous elements, forming the so-called mixed gangliocytoma-pituitary adenoma. The majority of mixed gangliocytoma adenomas are associated with endocrinopathies, mainly acromegaly and less often Cushing disease and hyperprolactinemia. In the present study, 10 cases of mixed gangliocytoma and somatotroph adenomas were evaluated for patterns of cellular differentiation and expression of lineage-specific transcription factors...
May 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28052137/mapping-polyclonal-hiv-1-antibody-responses-via-next-generation-neutralization-fingerprinting
#17
Nicole A Doria-Rose, Han R Altae-Tran, Ryan S Roark, Stephen D Schmidt, Matthew S Sutton, Mark K Louder, Gwo-Yu Chuang, Robert T Bailer, Valerie Cortez, Rui Kong, Krisha McKee, Sijy O'Dell, Felicia Wang, Salim S Abdool Karim, James M Binley, Mark Connors, Barton F Haynes, Malcolm A Martin, David C Montefiori, Lynn Morris, Julie Overbaugh, Peter D Kwong, John R Mascola, Ivelin S Georgiev
Computational neutralization fingerprinting, NFP, is an efficient and accurate method for predicting the epitope specificities of polyclonal antibody responses to HIV-1 infection. Here, we present next-generation NFP algorithms that substantially improve prediction accuracy for individual donors and enable serologic analysis for entire cohorts. Specifically, we developed algorithms for: (a) selection of optimized virus neutralization panels for NFP analysis, (b) estimation of NFP prediction confidence for each serum sample, and (c) identification of sera with potentially novel epitope specificities...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/27833183/couple-beads-an-integrated-method-of-natural-family-planning
#18
George Mulcaire-Jones, Richard J Fehring, Megan Bradshaw, Karen Brower, Gonzaga Lubega, Paskazia Lubega
Various fertility indicators are used by natural family planning methods to identify the fertile and infertile phases of a woman's menstrual cycle: mucus observations, cycle-day probabilities, basal body temperature readings, and hormonal measures of LH and estrogen. Simplified NFP methods generally make use of a single fertility indicator such as cycle-day probabilities (Standard Days Method) or mucus observations (Billings Ovulation Method). The Couple Bead Method integrates the two simplest fertility indicators, cycle-day probabilities and mucus observations, expanding its applicability to all women, regardless of cycle regularity and length...
February 2016: Linacre Quarterly
https://www.readbyqxmd.com/read/27803939/mechanoreceptor-reinnervation-of-autografts-versus-allografts-after-anterior-cruciate-ligament-reconstruction
#19
Simon W Young, Roberto D Valladares, Florence Loi, Jason L Dragoo
BACKGROUND: Loss of proprioceptive function occurs after anterior cruciate ligament (ACL) rupture. Clinical, motor, and proprioceptive function is known to improve after ACL reconstruction but does not return to normal. While histological studies of human ACL allografts have been unable to demonstrate mechanoreceptor reinnervation, animal data suggest that reinnervation may occur when an autograft is used. PURPOSE: To compare the presence or absence of mechanoreceptors between allograft versus autograft after ACL reconstruction in humans...
October 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27799772/highly-sensitive-detection-of-protein-biomarkers-via-nuclear-magnetic-resonance-biosensor-with-magnetically-engineered-nanoferrite-particles
#20
Minhong Jeun, Sungwook Park, Hakho Lee, Kwan Hyi Lee
Magnetic-based biosensors are attractive for on-site detection of biomarkers due to the low magnetic susceptibility of biological samples. Here, we report a highly sensitive magnetic-based biosensing system that is composed of a miniaturized nuclear magnetic resonance (NMR) device and magnetically engineered nanoferrite particles (NFPs). The sensing performance, also identified as the transverse relaxation (R2) rate, of the NMR device is directly related to the magnetic properties of the NFPs. Therefore, we developed magnetically engineered NFPs (MnMg-NFP) and used them as NMR agents to exhibit a significantly improved R2 rate...
2016: International Journal of Nanomedicine
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