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https://www.readbyqxmd.com/read/29317599/dna-methylome-variation-in-a-perinatal-nurse-visitation-program-that-reduces-child-maltreatment-a-27-year-follow-up
#1
Kieran J O'Donnell, Li Chen, Julia L MacIsaac, Lisa M McEwen, Thao Nguyen, Katherine Beckmann, Yuecai Zhu, Lawrence Ming Chen, Jeanne Brooks-Gunn, David Goldman, Elena L Grigorenko, James F Leckman, Josie Diorio, Neerja Karnani, David L Olds, Joanna D Holbrook, Michael S Kobor, Michael J Meaney
This study reveals the influence of child maltreatment on DNA methylation across the genome and provides the first evidence that a psychosocial intervention program, the Nurse Family Partnership (NFP), which targets mothers at risk for abusive parenting, associates with variation in the DNA methylome in adult offspring. The 188 participants were born to women randomly assigned to control (n = 99) or nurse-visited intervention groups (n = 89) and provided blood samples and a diagnostic interview at age 27 years...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29315324/a-novel-biomarker-for-prediction-of-atrial-fibrillation-susceptibility-in-patients-with-celiac-disease
#2
Selcuk Kucukseymen, Ayhan Hilmi Cekin, Nermin Bayar, Sakir Arslan, Elif Uygur Kucukseymen, Tanju Mercan, Semir Ozdemir
BACKGROUND: Celiac disease (CD), a serious autoimmune disorder that occurs in people who are genetically predisposed, is induced by dietary gluten intake and affects primarily the small intestine. Many studies have identified an increased risk of cardiovascular problems in patients with CD. Moreover, these patients are susceptible to certain liver diseases, as well as fibrosis. OBJECTIVE: The aim of this study was to assess the presence of fibrosis using the De Ritis ratio, determining its effect on the electromechanical features of the left atrium and its susceptibility to atrial fibrillation (AF) in patients with CD...
2018: PloS One
https://www.readbyqxmd.com/read/29285366/clinical-effects-and-safety-of-intra-arterial-infusion-therapy-of-cisplatin-suspension-in-lipiodol-combined-with-5-fluorouracil-versus-sorafenib-for-advanced-hepatocellular-carcinoma-with-macroscopic-vascular-invasion-without-extra-hepatic-spread-a-prospective
#3
Masahito Nakano, Takashi Niizeki, Hiroaki Nagamatsu, Masatoshi Tanaka, Ryoko Kuromatsu, Manabu Satani, Shusuke Okamura, Hideki Iwamoto, Shigeo Shimose, Tomotake Shirono, Yu Noda, Hironori Koga, Takuji Torimura
Although sorafenib and hepatic arterial infusion chemotherapy (HAIC) have been proven to improve prognosis in hepatocellular carcinoma (HCC) patients with macroscopic vascular invasion (MVI), the most appropriate approach remains unclear. The present multicenter, non-randomized, prospective cohort study aimed to compare the efficacy and safety of HAIC and sorafenib in patients with advanced HCC and MVI, without extra-hepatic spread (EHS) and Child-Pugh class A disease. The present study was performed between April 2008 and March 2014, and 64 HCC patients with MVI, without EHS and Child-Pugh class A disease were registered...
December 2017: Molecular and Clinical Oncology
https://www.readbyqxmd.com/read/29249949/modulation-of-neural-activity-during-guided-viewing-of-visual-art
#4
Guillermo Herrera-Arcos, Jesús Tamez-Duque, Elsa Y Acosta-De-Anda, Kevin Kwan-Loo, Mayra de-Alba, Ulises Tamez-Duque, Jose L Contreras-Vidal, Rogelio Soto
Mobile Brain-Body Imaging (MoBI) technology was deployed to record multi-modal data from 209 participants to examine the brain's response to artistic stimuli at the Museo de Arte Contemporáneo (MARCO) in Monterrey, México. EEG signals were recorded as the subjects walked through the exhibit in guided groups of 6-8 people. Moreover, guided groups were either provided with an explanation of each art piece (Guided-E), or given no explanation (Guided-NE). The study was performed using portable Muse (InteraXon, Inc, Toronto, ON, Canada) headbands with four dry electrodes located at AF7, AF8, TP9, and TP10...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/29069985/neural-autoantibodies-in-patients-with-neurological-symptoms-and-histories-of-chemical-mold-exposures
#5
Mohamed Bahie Abou-Donia, Allan Lieberman, Luke Curtis
A number of studies have linked exposures to industrial and household chemicals and biological toxins to increased risk of autoimmunity in general and elevated levels of autoantibodies to neural antigens specifically. Elevated neural autoantibodies are biomarkers for many diseases such as multiple sclerosis and Parkinson's disease. Our study reports levels of six types of neural autoantibodies in a group of 24 toxicant-exposed patients. The patients were exposed to a variety of toxicants including contaminated drinking water (four patients), building water/mold damage (eight patients), pesticides (four patients), and other assorted toxic chemicals (eight patients)...
January 1, 2017: Toxicology and Industrial Health
https://www.readbyqxmd.com/read/29022144/a-qualitative-evaluation-of-engagement-and-attrition-in-a-nurse-home-visiting-program-from-the-participant-and-provider-perspective
#6
Lana O Beasley, Leigh E Ridings, Tyler J Smith, Jennifer D Shields, Jane F Silovsky, William Beasley, David Bard
Beginning parenting programs in the prenatal and early postnatal periods have a large potential for impact on later child and maternal outcomes. Home-based parenting programs, such as the Nurse Family Partnership (NFP), have been established to help address this need. Program reach and impact is dependent on successful engagement of expecting mothers with significant risks; however, NFP attrition rates remain high. The current study qualitatively examined engagement and attrition from the perspectives of NFP nurses and mothers in order to identify mechanisms that enhance service engagement...
October 11, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28966142/comparative-proteomic-analysis-between-two-haemocyte-subpopulations-in-shrimp-fenneropenaeus-chinensis
#7
Lei Zhu, Yanhong Chang, Jing Xing, Xiaoqian Tang, Xiuzhen Sheng, Wenbin Zhan
In our previous work, granulocytes and hyalinocytes were successfully separated by immunomagnetic bead (IMB) method using monoclonal antibodies (mAbs) against granulocytes of shrimp (Fenneropenaeus chinensis). In order to elucidate the proteomic differentiation between granulocytes and hyalinocytes, in this paper, the differentially expressed proteins were analyzed between non-fixed/un-permeabilized (NFP) haemocytes and fixed/permeabilized (FP) haemocytes using two-dimensional gel electrophoresis (2-DE) combined with mass spectrometry (MS)...
September 28, 2017: Fish & Shellfish Immunology
https://www.readbyqxmd.com/read/28963796/are-eating-disorders-all-about-control-the-elusive-psychopathology-of-nonfat-phobic-presentations
#8
Helen B Murray, Kathryn Coniglio, Andrea S Hartmann, Anne E Becker, Kamryn T Eddy, Jennifer J Thomas
OBJECTIVE: There are a subset of individuals with eating disorders (EDs) who do not overevaluate body shape/weight (i.e., nonfat phobic ED; NFP-ED). According to the transdiagnostic cognitive-behavioral conceptualization of EDs, a need for control, in general, is hypothesized as the core psychopathology of NFP-EDs, with shape- and weight-related motivations for ED behavior merely superimposed in FP-ED presentations. This study tested the need for control as motivation for restriction in NFP-ED, using items aimed at assessing control from the Eating Disorder Examination (EDE) Restraint scale...
November 2017: International Journal of Eating Disorders
https://www.readbyqxmd.com/read/28957033/us-consumers-understanding-of-nutrition-labels-in-2013-the-importance-of-health-literacy
#9
Alexander Persoskie, Erin Hennessy, Wendy L Nelson
INTRODUCTION: We examined US adults' understanding of a Nutrition Facts panel (NFP), which requires health literacy (ie, prose, document, and quantitative literacy skills), and the association between label understanding and dietary behavior. METHODS: Data were from the Health Information National Trends Survey, a nationally representative survey of health information seeking among US adults (N = 3,185) conducted from September 6, 2013, through December 30, 2013...
September 28, 2017: Preventing Chronic Disease
https://www.readbyqxmd.com/read/28952311/stereoretentive-ligand-exchange-reactions-of-n-fused-porphyrin-ruthenium-ii-complexes
#10
Hideaki Matsuo, Motoki Toganoh, Masatoshi Ishida, Shigeki Mori, Hiroyuki Furuta
The ligand exchange reactions of the ruthenium(II) complex of N-fused tetraphenylporphyrin, Ru(NFp)(CO)2Cl (2), with various anions were investigated. The chloride ligand of the isomers 2a-c was stereoretentively exchanged with bromide (Br(-)), iodide (I(-)), and acetate (AcO(-)) anions in toluene at 100 °C, structures of which were confirmed by (1)H NMR as well as single crystal X-ray diffraction analysis. The silver (AgOAc, AgOTf) and boron (NaBPh4) reagents also afforded the corresponding stereoretentive products...
September 27, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28942188/study-of-a-tropical-soil-in-order-to-use-it-to-retain-aluminum-iron-manganese-and-fluoride-from-acid-mine-drainage
#11
Miriam Gonçalves Miguel, Rodrigo Paiva Barreto, Sueli Yoshinaga Pereira
The Ore Treatment Unit (UTM-Caldas), in the city of Caldas, Minas Gerais, Brazil, nowadays in decommissioning stage, was the first uranium extraction mine in Brazil. Several negative environmental impacts in the area have occurred, because of mining, treatment and beneficiation processes. Waste rock pile 4 (WRP-4) generates acid mine drainage (AMD), which is discharged in the Nestor Figueiredo retention pond (NFP). However, leakage of acid water by the NFP dam foundation has been constantly observed. Therefore, this research aimed to investigate a typical tropical soil, in order to use it as mineral liner for the NFP to minimize the leakage of acid water through the dam foundation and to retain predominant chemical species...
December 15, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28885119/volume-of-distribution-and-clearance-of-peptide-based-nanofiber-after-convection-enhanced-delivery
#12
Ranjodh Singh, Vanessa Bellat, Melinda Wang, Melanie E Schweitzer, Y Linda Wu, Ching-Hsuan Tung, Mark M Souweidane, Benedict Law
OBJECTIVE Drug clearance may be a limiting factor in the clinical application of convection-enhanced delivery (CED). Peptide-based nanofibers (NFPs) have a high aspect ratio, and NFPs loaded with drugs could potentially maintain effective drug concentrations for an extended period sufficient for cancer therapy. The objective of this study was to assess the volume of distribution (Vd) and clearance of variable lengths of NFPs when administered using CED. METHODS NFPs composed of multiple methoxypolyethylene glycol (mPEG)-conjugated constructs (mPEG2000-KLDLKLDLKLDL-K( FITC)-CONH2, for which FITC is fluorescein isothiocyanate) were assembled in an aqueous buffer...
September 8, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28875469/a-panel-of-autoantibodies-against-neural-proteins-as-peripheral-biomarker-for-pesticide-induced-neurotoxicity
#13
Heba Allah Abd El Rahman, Mohamed Salama, Seham A Gad El-Hak, Mona A El-Harouny, Passent ElKafrawy, Mohamed B Abou-Donia
In the present study, we screened the sera of subjects chronically exposed to mixtures of pesticides (composed mainly of organophosphorus compounds (OPs) and others) and developed neurological symptoms for the presence of autoantibodies against cytoskeletal neural proteins. OPs have a well-characterized clinical profile resulting from acute cholinergic crisis. However, some of these compounds cause neuronal degeneration and demyelination known as organophosphorus compound-induced delayed neurotoxicity (OPIDN) and/or organophosphorus compound-induced chronic neurotoxicity (OPICN)...
September 5, 2017: Neurotoxicity Research
https://www.readbyqxmd.com/read/28812181/visit-attendance-patterns-in-nurse-family-partnership-community-sites
#14
Margaret L Holland, David L Olds, Ann M Dozier, Harriet J Kitzman
We examined visit attendance patterns of mothers enrolled in the Nurse-Family Partnership (NFP) home visitation program and associations between these patterns and characteristics of the families and sites, with the goal of increasing participant engagement. We utilized repeated measures latent class analysis to identify attendance patterns among 66,967 mothers in NFP sites across the USA. Mothers enrolled from 1996 to 2010. Data were collected by home visitors and aggregated by the NFP National Service Office...
August 15, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
https://www.readbyqxmd.com/read/28803581/nutrition-facts-panel-use-is-associated-with-diet-quality-and-dietary-patterns-among-latinos-with-type-2-diabetes
#15
Grace Kollannoor-Samuel, Sofia Segura-Pérez, Fatma M Shebl, Nicola L Hawley, Grace Damio, Jyoti Chhabra, Sonia Vega-López, Maria Luz Fernandez, Rafael Pérez-Escamilla
OBJECTIVE: The study aims were to (i) identify determinants of Nutrition Facts Panel (NFP) use and (ii) describe the association between NFP use and dietary intake among Latinos with type 2 diabetes. DESIGN: Baseline cross-sectional data from a clinical trial were used to assess the association between NFP use and dietary intake. Diet was measured using two methods: (i) a diet quality score (the Healthy Eating Index-2010) derived from a single 24 h recall and (ii) dietary pattern (exploratory factor analyses) from an FFQ...
August 14, 2017: Public Health Nutrition
https://www.readbyqxmd.com/read/28800009/pathologic-prognostic-factors-of-pineal-parenchymal-tumor-of-intermediate-differentiation
#16
Debajyoti Chatterjee, Khushboo Lath, Navneet Singla, Narendra Kumar, Bishan D Radotra
INTRODUCTION: Pineal parenchymal tumor of intermediate differentiation (PPTID) is an uncommon tumor of the pineal gland. Although this behaves as a grade II/III tumor, the exact clinical behavior is not well known. There is no well-established pathologic factor that can predict the behavior of PPTID. AIM AND OBJECTIVE: The aim of this study was to determine the pathologic prognostic factors in PPTID. MATERIALS AND METHODS: All PPTID cases diagnosed between 2006 and 2016 were analyzed retrospectively...
August 9, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28654739/poliomyelitis-eradication-%C3%A2-the-review-of-notifications-from-the-years-2010-2016-sent-to-national-ihr-focal-point
#17
Franciszek Radziszewski, Janusz Janiec, Łukasz Henszel, Radosław Izdebski, Piotr Polański
Polio eradication programme was launched after World Health Assembly in 1988. Despite considerable decrease in reported cases it still constitutes a significant public health threat. All WHO member state is bound to appoint National IHR Focal Point, which operates based on International Health Regulations (2005), which were enacted during the World Health Assembly in 2005. In Poland National IHR Focal Point (IHR NFP in Poland) operates since 2007, and is located in the Department of Epidemiology, in National Institute of Public Health - National Institute of Hygiene...
2017: Przegla̧d Epidemiologiczny
https://www.readbyqxmd.com/read/28637215/managerial-ownership-in-nursing-homes-staffing-quality-and-financial-performance
#18
Sean Shenghsiu Huang, John R Bowblis
Purpose of the Study: Ownership of nursing homes (NHs) has primarily focused broadly on differences between for-profit (FP), nonprofit (NFP), and government-operated facilities. Yet, among FPs, the understanding of detailed ownership structures at individual NHs is rather limited. Particularly, NH administrators may hold significant equity interests in their facilities, leading to heterogeneous financial incentives and NH outcomes. Through the principal-agent theory, this article studies how managerial ownership of individual facilities affects NH outcomes...
June 20, 2017: Gerontologist
https://www.readbyqxmd.com/read/28587834/spasmogenic-effects-of-the-proteasome-inhibitor-carfilzomib-on-coronary-resistance-vascular-tone-and-reactivity
#19
Carol Chen-Scarabelli, Giovanni Corsetti, Evasio Pasini, Francesco S Dioguardi, Gagan Sahni, Jagat Narula, Mara Gavazzoni, Hemang Patel, Louis Saravolatz, Richard Knight, Riccardo Raddino, Tiziano M Scarabelli
BACKGROUND: Carfilzomib (CFZ) is a new proteasome inhibitor used for the treatment of multiple myeloma. Besides heart failure, angina and myocardial ischemia occurred following administration of CFZ, which is not contraindicated in patients with recent myocardial infarction/unstable angina excluded from the safety trials. AIM OF STUDY: To test the effects of CFZ (10(-9) to 10(-7)mol/L) on vascular tone and reactivity in the isolated rabbit heart and aorta. METHODS AND RESULTS: CFZ administered by bolus injection to the isolated heart increased coronary perfusion pressure (CPP) at all tested concentrations and mildly raised left ventricular pressure and heart rate, only at the highest concentration...
July 2017: EBioMedicine
https://www.readbyqxmd.com/read/28586636/effectiveness-of-an-online-natural-family-planning-program-for-breastfeeding-women
#20
Richard J Fehring, Mary Schneider, Thomas Bouchard
OBJECTIVE: To analyze the effectiveness of an online, nurse-managed natural family planning (NFP) program among breastfeeding women and subgroups of these women. DESIGN: Longitudinal comparative cohort study. SETTING: A university-based online NFP education program and menstrual cycle charting system. PARTICIPANTS: Women (N = 816) with a mean age of 30.3 years (standard deviation = 4.5) who registered to use the online NFP system and indicated they were breastfeeding...
June 3, 2017: Journal of Obstetric, Gynecologic, and Neonatal Nursing: JOGNN
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