Alexis Dumortier, Robin Jeannet, Peggy Kirstetter, Eva Kleinmann, MacLean Sellars, Nuno R dos Santos, Christelle Thibault, Jochen Barths, Jacques Ghysdael, Jennifer A Punt, Philippe Kastner, Susan Chan
The Ikaros transcription factor is both a key regulator of lymphocyte differentiation and a tumor suppressor in T lymphocytes. Mice carrying a hypomorphic mutation (Ik(L/L)) in the Ikaros gene all develop thymic lymphomas. Ik(L/L) tumors always exhibit strong activation of the Notch pathway, which is required for tumor cell proliferation in vitro. Notch activation occurs early in tumorigenesis and may precede transformation, as ectopic expression of the Notch targets Hes-1 and Deltex-1 is detected in thymocytes from young Ik(L/L) mice with no overt signs of transformation...
January 2006: Molecular and Cellular Biology