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sellar region lymphoma

Rakesh K Gupta, Ravindra K Saran, Arvind K Srivastava, Anita Jagetia, Lalit Garg, Mehar C Sharma
We present a rare case of primary pituitary T cell lymphoma/leukemia (T-LBL) in association with adrenocorticotropic hormone (ACTH) and thyroid stimulating hormone (TSH) expressing pituitary adenoma in a 55-year-old woman highlighting the importance of intra-operative squash smears examination. The patient presented with complaints of headache, diminution of vision and recent onset altered sensorium. MRI revealed a mass lesion in the sellar-suprasellar region with non-visualization of pituitary gland separately, extending to involve adjacent structures diagnosed as invasive pituitary macroadenoma...
March 13, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
Arthur Wang, Nathan Carberry, Elena Solli, George Kleinman, Adesh Tandon
We present an unusual case of a metastatic mantle cell lymphoma (MCL) to the pituitary gland. The patient had a known history of MCL for which she previously received chemotherapy. She presented with new-onset diplopia and confusion, and reported a history of progressive vision blurriness associated with headache, nausea, and vomiting. MRI of the brain showed an enhancing lesion within the sella turcica involving the cavernous sinuses bilaterally, extending into Meckel's cave on the left, and abutting the optic nerves bilaterally...
January 2016: Case Reports in Oncology
Javaria Ahsan, Shoaib Naiyar Hashmi, Iqbal Muhammad, Hafeez Ud Din, Ahsan Masood Butt, Sajid Nazir, Muhammad Azhar
BACKGROUND: The incidence of central nervous system (CNS) tumours has rapidly increased over the past few years. There is no accurate nationwide CNS tumour epidemiology in Pakistan that makes policy making for tumour screening and early treatment difficult. The purpose of this study was to provide the spectrum of CNS tumours in a premier diagnostic and referral centre of Pakistan. METHODS: This cross-sectional study was carried out at Histopathology Department, Armed Forces Institute of Pathology over a period of 5 years...
January 2015: Journal of Ayub Medical College, Abbottabad: JAMC
O F Tropinskaya, N K Serova, A V Golanov, G L Kobyakov, L V Shishkina, V L Puchkov, S V Zolotova, E V Vinogradov
This work was aimed at studying the optimal diagnosis methods and features of clinical signs of malignant B-cell lymphoma of the anterior visual pathways and choosing the most reasonable treatment method. Six immunocompetent patients with lymphomas in the chiasm-sellar region were examined. The outcomes of high-dose methothrexate chemotherapy and radiotherapy in these patients are analyzed.
2014: Zhurnal Voprosy Neĭrokhirurgii Imeni N. N. Burdenko
Takao Koiso, Hiroyoshi Akutsu, Shingo Takano, Tetsuya Yamamoto, Eiichi Ishikawa, Yasushi Okoshi, Akira Matsumura
The entity of pituitary (sellar or parasellar) lymphoma includes primary pituitary lymphoma (PPL) and secondary pituitary lymphoma (SPL). The latter has an involvement of systemic lymphoma. Both of these lymphomas are extremely rare. We describe a patient with SPL showing a good prognosis. A 78-year-old woman presented with diplopia, left ptosis, and back pain. Magnetic resonance (MR) imaging revealed a parasellar mass lesion extending to the upper clivus and another mass lesion with compression fracture of the Th3 vertebral body...
2014: Case Reports in Medicine
Junjie Yang, Na Zhao, Guangsen Zhang, Wenli Zheng
It is rare for systemic non-Hodgkin's lymphoma (NHL) to metastasize to the hypothalamus and pituitary glands. The present study describes two patients with NHL and diabetes insipidus (DI) and 17 patients from the literature in order to analyze the clinical features of patients with NHL metastasizing to the pituitary glands. Diffuse large B cell lymphoma (DLBCL) was observed to be the most common type of NHL involving the hypothalamus-pituitary axis. A total of 11 patients (57.9%) had been diagnosed with DI (post-pituitary involvement), five (26...
May 2013: Oncology Letters
Liang Chen, Xiang Zou, Yin Wang, Ying Mao, Liangfu Zhou
BACKGROUND: Tumor epidemiology is a significant part of CNS (central nervous system) tumor studies. Reassessment of original sections can update our knowledge of tumor spectrum. Here, we discuss the features of CNS tumor pathology in a single center. METHODS: A total of 34140 cases from 1950 to 2009 were collected; sections from 1990 to 2009 were reassessed according to WHO 2007 classification, and cases from 1950 to 1989 were classified according to the previous pathological diagnosis...
May 2, 2013: BMC Clinical Pathology
Inanç Karapolat, Güray Oncel, Kamil Kumanlıoğlu
UNLABELLED: We report a case with Non-Hodgkin Lymphoma with a focus of intense hypermetabolism in the sellar region in the primary staging and posttreatment whole body F-18 FDG PET. Further evaluation with magnetic resonance imaging after posttreatment FDG PET revealed a pituitary adenoma. Endocrinologic workup was normal consistent with nonfunctioning pituitary adenoma and endocrinologists decided to follow up the patient by yearly magnetic resonance imaging. This case demonstrates a nonfunctioning pituitary adenoma by whole body FDG PET and emphasizes the importance of pursuing incidental findings detected in the sella on PET imaging...
April 2013: Molecular Imaging and Radionuclide Therapy
Labrini Papanastasiou, Theodora Pappa, Aikaterini Dasou, Efi Kyrodimou, George Kontogeorgos, Christianna Samara, Panagiotis Bacaracos, Athanasios Galanopoulos, George Piaditis
OBJECTIVE: Primary central nervous system (CNS) non-Hodgkin's lymphoma is a rarely encountered clinical entity. Here we present a case of a primary CNS diffuse large B-cell non-Hodgkin's lymphoma developed on a previously operated and irradiated pituitary macroadenoma. DESIGN-RESULTS: A 60-year-old woman presented with muscle weakness and eye lid ptosis. Thirty years ago, she was diagnosed with a non-functioning pituitary macroadenoma requiring repeated incomplete operations and conventional radiotherapy and accompanied by partial anterior pituitary deficiency...
October 2012: Hormones: International Journal of Endocrinology and Metabolism
Agustí Alentorn, Marc Sanson, Karima Mokhtari, Yannick Marie, Khê Hoang-Xuan, Jean-Yves Delattre, Ahmed Idbaih
Primary CNS tumors (PCNSTs) encompass a broad and heterogeneous group of tumors, including gliomas, meningiomas, embryonal tumors, primary CNS lymphomas, CNS germ cell tumors and sellar region tumors. In recent decades, research has focused on understanding the clinical and biological significance of molecular abnormalities detected in PCNSTs. The emergence of genomic arrays, including comparative genomic hybridization and SNP arrays, have helped in the discovery of novel critically important genes and novel genomic biomarkers involved in PCNST oncogenesis (e...
April 2012: Expert Review of Molecular Diagnostics
Stefan Grau, Ulrich Schueller, Carolin Weiss, Jörg-Christian Tonn
BACKGROUND: Most primary lymphomas of the central nervous system (CNS) are of B-cell origin and are found intra-axially, with a few reported cases of skull base tumors involving the upper clivus or sellar region or both. In this case, a tumor resembling a clivus meningioma without osseous involvement was surgically removed and turned out to be a primary T-cell lymphoma. CASE REPORT: A 60-year-old woman presented with slight right-sided abducens nerve palsy. Cranial imaging revealed an extra-axial mass at the caudal clivus resembling a meningioma...
October 2010: World Neurosurgery
Shu-Mei Chen, Chen-Nen Chang, Kuo-Chen Wei, Shih-Ming Jung, Chi-Cheng Chuang
Lymphomas can occur throughout the body, but are relatively rare in the sphenoid region. The clinical presentations are atypical, ranging from nasal symptoms, pituitary hormone dysfunction and neurological impairment. We report a 63-year-old female patient who suffered nasal discharge, retro-ocular pain and left lateral gaze palsy for 3 months. Cranial MRI revealed sellar and suprasellar lesions involving the clivus, cavernous sinus and sphenoid sinus. The patient was treated for chronic sphenoid sinusitis...
October 2008: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
Alexis Dumortier, Robin Jeannet, Peggy Kirstetter, Eva Kleinmann, MacLean Sellars, Nuno R dos Santos, Christelle Thibault, Jochen Barths, Jacques Ghysdael, Jennifer A Punt, Philippe Kastner, Susan Chan
The Ikaros transcription factor is both a key regulator of lymphocyte differentiation and a tumor suppressor in T lymphocytes. Mice carrying a hypomorphic mutation (Ik(L/L)) in the Ikaros gene all develop thymic lymphomas. Ik(L/L) tumors always exhibit strong activation of the Notch pathway, which is required for tumor cell proliferation in vitro. Notch activation occurs early in tumorigenesis and may precede transformation, as ectopic expression of the Notch targets Hes-1 and Deltex-1 is detected in thymocytes from young Ik(L/L) mice with no overt signs of transformation...
January 2006: Molecular and Cellular Biology
W Müller-Forell
Intracranial pathologies involving the visual pathway are manifold. Aligning to anatomy, the most frequent and/or most important extrinsic and intrinsic intracranial lesions are presented. Clinical symptoms and imaging characteristics of lesions of the sellar region are demonstrated in different imaging modalities. The extrinsic lesions mainly consist of pituitary adenomas, meningeomas, craniopharyngeomas and chordomas. In (asymptomatic and symptomatic) aneurysms, different neurological symptoms depend on the location of aneurysms of the circle of Willis...
February 2004: European Journal of Radiology
Jeong Hyun Lee, Ho Kyu Lee, Choong Ton Choi, Jooryung Huh
We report the MR features in a previously healthy patient with mucosa-associated lymphoid tissue lymphoma of the pituitary gland. The MR images showed a homogeneously enhancing solid mass in the sellar region and both parasellar regions; this mass extended through the bilateral foramina ovale along the third branches of the trigeminal nerves. The mass completely encircled the cavernous segments of both internal carotid arteries without narrowing the lumen. Gadopentetate dimeglumine-enhanced T1-weighted MR images showed homogeneous, strong enhancement of the mass...
May 2002: AJNR. American Journal of Neuroradiology
R E Landman, S L Wardlaw, R J McConnell, A G Khandji, J N Bruce, P U Freda
An 86-yr-old woman presented with fever of unknown origin. When laboratory evaluation revealed partial hypopituitarism, a magnetic resonance imaging scan of the head was performed and revealed a sellar mass consistent with a pituitary adenoma. Only after other possible etiologies for fever were excluded did she undergo transsphenoidal resection of the sellar mass, which proved to be a B-cell lymphoma. Primary central nervous system lymphoma of the pituitary region is a rare cause of a sellar mass, and this is the first reported case of pituitary lymphoma whose presenting manifestation was fever of unknown origin...
April 2001: Journal of Clinical Endocrinology and Metabolism
S Singh, R S Cherian, B George, S Nair, A Srivastava
The MR imaging findings in a patient with non-Hodgkin's lymphoma with unusual involvement of the sella, pituitary stalk and left parasellar region are reported here. On the basis of the MR imaging findings, the initial differential diagnosis included invasive pituitary adenoma, a granulomatous lesion and en plaque meningioma. Trans-sphenoidal biopsy of the sellar mass showed chronic inflammatory changes and the patient was initially treated for tuberculosis. Because follow-up imaging showed the lesion to be progressive, a biopsy was done of an enlarged right inguinal lymph node...
February 2000: Australasian Radiology
D Kuhn, M Buchfelder, T Brabletz, W Paulus
A mixed lymphoblastic T cell lymphoma and gonadotroph cell pituitary adenoma occurred 25 years after first resection of the adenoma. Within 1 year the lymphoma overgrew the adenoma, but was still restricted to the sellar region. Histologically, lymphoma and adenoma components were tightly admixed. Possible pathogenetic pathways for intra-adenomatous lymphoma development include monoclonal expansion of T cell infiltrates, expression of adhesion molecules specific for adenoma endothelium, and production of mitogenic pituitary hormones...
March 1999: Acta Neuropathologica
Y Sakakibara, M Matsuzawa, Y Taguchi, H Sekino, T Shinagawa, M Abe, M Tadokoro
A case of primary T cell type malignant lymphoma of the sellar region was reported. This 53-year-old male was admitted to our neurosurgical service because of slowly progressive occipitalgia and diplopia over the previous 5 months. On admission neurological examination revealed a slight limitation of the lateral movement of the left eye. Endocrinological examination showed no abnormalities. Despite a mild neurological deficit, a CT scan revealed an extensive bony destruction around the sellar region including the dorsum sellae, the bilateral petrous apices, and the upper two thirds of the clivus...
January 1998: No Shinkei Geka. Neurological Surgery
A L Taratuto, G Sevlever, P Piccardo
We present a 6-year experience on 307 stereotactic biopsy specimens of the central nervous system using Leksell's and Talairach's systems independently and either Leksell or Sedan needles. Patients with deep cerebral lesions (basal ganglia, parasellar, pineal, or third ventricle), those located in highly functional areas or those poorly defined on imaging studies, as well as candidates for brachytherapy, were selected. Smear examination during surgery was a routine procedure followed by conventional histologic methods...
June 1991: Archives of Pathology & Laboratory Medicine
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