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craniopharyngioma endocrine

J Doyen, P-Y Bondiau, K Benezery, J Thariat, M Vidal, A Gérard, J Hérault, C Carrie, J-M Hannoun-Lévi
Purpose was to summarize results for proton therapy in cancer treatment. A systematic review has been done by selecting studies on the website (Medline) and using the following keywords: proton therapy, radiation therapy, cancer, chordoma, chondrosarcoma, uveal melanoma, retinoblastoma, meningioma, glioma, neurinoma, pituitary adenoma, medulloblastoma, ependymoma, craniopharyngioma and nasal cavity. There are several retrospective studies reporting results for proton therapy in cancer treatments in the following indications: ocular tumors, nasal tumors, skull-based tumors, pediatric tumors...
October 2016: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
Hoffmann Anika, Hermann L MüLLER
INTRODUCTION: Non-alcoholic fatty liver disease (NAFLD) presents a disease with a wide spectrum spanning from benign steatosis to steatohepatitis with fibrosis and scarring that can lead to cirrhosis. With increasing prevalence, NAFLD is developing into the leading indication for liver transplantation worldwide. Disturbances in endocrine, hypothalamic-pituitary axes have been associated with NALFD, including GH deficiency, hypothyroidism, hypercortisolaemia, and hypogonadism. EVIDENCE OF ACQUISITION AND SYNTHESIS: In this review, we examine the published data (search: PUBMED, 1990-2016) suggesting a link between endocrine abnormalities of hypothalmic-pituitary axes and NAFLD and summarise the clinical data on risk factors for NAFLD in specific diseases involving hypothalmic-pituitary axes...
July 13, 2016: Minerva Endocrinologica
Johannes A Romijn
Ultimately, almost all patients who are appropriately treated for pituitary tumours enter a chronic phase with control or cure of hormonal excess, adequate treatment of pituitary insufficiency and relief of mass effects. This phase is associated with improvement of initial signs and symptoms, but also with the persistent consequences of the initial disease and associated treatments. Pituitary insufficiency is a common denominator in many of these patients, and is associated with a reduction in quality of life, despite adequate endocrine substitution...
September 2016: Nature Reviews. Endocrinology
Sivashanmugam Dhandapani, Harminder Singh, Hazem M Negm, Salomon Cohen, Mark M Souweidane, Jeffrey P Greenfield, Vijay K Anand, Theodore H Schwartz
OBJECTIVE Craniopharyngiomas can be difficult to remove completely based on their intimate relationship with surrounding visual and endocrine structures. Reoperations are not uncommon but have been associated with higher rates of complications and lower extents of resection. So radiation is often offered as an alternative to reoperation. The endonasal endoscopic transsphenoidal approach has been used in recent years for craniopharyngiomas previously removed with craniotomy. The impact of this approach on reoperations has not been widely investigated...
May 6, 2016: Journal of Neurosurgery
N N Tagoe, V A Essuman, G Fordjuor, J Akpalu, P Bankah, T Ndanu
BACKGROUND: Anecdotally, increasing number of patients are seen at Korle Bu Teaching Hospital (KBTH) with brain tumour. Neuro-ophthalmic symptoms and signs may help in timely diagnosis and intervention. OBJECTIVE: To evaluate the neuro-ophthalmic and clinical characteristics of brain tumour in patients presenting at a tertiary hospital in Ghana. STUDY DESIGN: A prospective case series involving 36 consecutive patients newly diagnosed with brain tumour from November 2010 to October 2011, at the Ophthalmology, Neurosurgery and Endocrine units of KBTH, Ghana...
September 2015: Ghana Medical Journal
Shaheryar F Ansari, Reilin J Moore, Joel C Boaz, Daniel H Fulkerson
OBJECT Radioactive phosphorus-32 (P32) has been used as brachytherapy for craniopharyngiomas with the hope of providing local control of enlarging tumor cysts. Brachytherapy has commonly been used as an adjunct to the standard treatment of surgery and external-beam radiation (EBR). Historically, multimodal treatment, including EBR, has shown tumor control rates as high as 70% at 10 years after treatment. However, EBR is associated with significant long-term risks, including visual deficits, endocrine dysfunction, and cognitive decline...
April 2016: Journal of Neurosurgery. Pediatrics
Mehran Soleymanha, Ali Karimi, Seyed Mojtaba Mehrdad
INTRODUCTION: Slipped capital femoral epiphysis is characterized by the slippage of the proximal femoral epiphysis on the metaphysis, which is sometimes associated with an underlying endocrine disorder. Panhypopituitarism due to craniopharyngioma has been reported several times. We report a case of craniopharyngioma recurrence leading to slipped capital femoral epiphysis. CASE PRESENTATION: A 28-year-old man diagnosed with recurrent craniopharyngioma presented with slipped capital femoral epiphysis...
August 2015: Trauma Monthly
Hermann L Müller
Childhood-onset craniopharyngiomas (CP) are rare embryonal malformations of low-grade histological malignancy. Hypothalamic involvement and/or treatment-related lesions result in impaired physical and social functionality and severe neuroendocrine sequelae. Quality of life in CP with hypothalamic involvement is impaired by severe obesity, physical fatigue, reduced motivation, dyspnea, diarrhea, and non-optimal psychosocial development. 567 CI patients have been recruited between 1998 and 2010 in the German Craniopharyngioma Registry...
2015: Expert Review of Neurotherapeutics
Tatsuya Kobayashi, Takahiko Tsugawa, Manabu Hatano, Chisa Hashizume, Yoshimasa Mori, Yuta Shibamoto
Evaluation of 30 cases of craniopharyngioma treated by Gamma Knife at Nagoya Radiosurgery Center (NRC), Nagoya Kyoritsu Hospital since July, 2004 has been made. The mean volume of the tumor was 2.64 ml, which was treated with the marginal dose of 11.7 Gy. Mean follow-up period was 79.9 months. The effects were evaluated by MRI findings, neuro-endocrine and hypothalamic signs and symptoms, complications and KPS every 3~6 months. As the results, complete remission was obtained in 8, partial remission in 12, no change in 6, progression in 3, in which two died by hypothalamic invasion...
August 2015: Nagoya Journal of Medical Science
Farida Chentli, Amel Safer-Tabi
INTRODUCTION: Pituitary stone or pituitary calculus is a scientific enigma characterized by a large calcification in the pituitary sella. It can be discovered incidentally or in a patient with endocrine and/or neurological problems. Its mechanism is not understood. In this article, we described three patients harboring a large pituitary calcification. CASE PRESENTATION: The first case was observed in a 27-year-old woman who consulted for secondary amenorrhea. The second case concerned a woman who consulted for infertility, and the third one was observed in an 11-year and nine-month-old girl who was sent to our department for short stature...
July 2015: International Journal of Endocrinology and Metabolism
Anika Hoffmann, Svenja Boekhoff, Ursel Gebhardt, Anthe S Sterkenburg, Anna M M Daubenbüchel, Maria Eveslage, Hermann L Müller
OBJECTIVE: Childhood craniopharyngiomas (CP) are often diagnosed after a long duration of history (DOH). Tumor size, hypothalamic involvement (HI), and obesity are associated with reduced overall survival (OS) and functional capacity (FC). The effect of DOH and specific symptoms in history on presentation at initial diagnosis and long-term prognosis are unknown. DESIGN: Retrospective analysis of patients' records and prospective longitudinal follow-up. METHODS: Histories of 411 CP patients recruited in HIT Endo, KRANIOPHARYNGEOM 2000 were retrospectively evaluated for DOH, symptoms, and characteristics...
December 2015: European Journal of Endocrinology
Ricky H Wong, Kenneth De Los Reyes, Puya Alikhani, Sananthan Sivaknathan, Jamie van Gompel, Harry van Loveren, Siviero Agazzi
BACKGROUND: Retrochiasmatic, retroinfundibular craniopharyngiomas are surgically challenging tumors. Anterolateral, posterolateral, and endoscopic endonasal approaches represent the most commonly used techniques to access these tumors, but all require an extensive exposure time, and each has its own risks and limitations. The subtemporal approach is a well-known neurosurgical approach that is rarely described for craniopharyngiomas. OBJECTIVE: To assess the feasibility, advantages, and disadvantages of a subtemporal approach for craniopharyngiomas...
August 18, 2015: Neurosurgery
Hoong-Wei Gan, Chloe Bulwer, Owase Jeelani, Michael Alan Levine, Márta Korbonits, Helen Alexandra Spoudeas
BACKGROUND: Pediatric pituitary adenomas are rare, accounting for <3 % of all childhood intracranial tumors, the majority of which are prolactinomas. Consequently, they are often misdiagnosed as other suprasellar masses such as craniopharyngiomas in this age group. Whilst guidelines exist for the treatment of adult prolactinomas, the management of childhood presentations of these benign tumors is less clear, particularly when dopamine agonist therapy fails. Given their rarity, childhood-onset pituitary adenomas are more likely to be associated with a variety of genetic syndromes, the commonest being multiple endocrine neoplasia type 1 (MEN-1)...
2015: International Journal of Pediatric Endocrinology
Yujiro Hattori, Shigeyuki Tahara, Takuya Nakakuki, Mao Takei, Yudo Ishii, Akira Teramoto, Akio Morita
Chondromas originating from the sella turcica are rare, and the most common initial symptoms are headache and visual disturbance. We describe a case of sellar chondroma with endocrine impairment as an initial manifestation that completely resolved after surgery. A 40-year-old Japanese woman with amenorrhea and galactorrhea for the last 2 years was referred to our department of neurosurgery for the evaluation of high prolactin levels and a tumor in the sella turcica. A biochemical assessment indicated endocrine dysfunction...
2015: Journal of Nippon Medical School, Nippon Ika Daigaku Zasshi
Inés Castro-Dufourny, Rodrigo Carrasco, Ruth Prieto, José M Pascual
The birth of clinical neuroendocrinology can be dated to the year 1900, when the French neurologist Joseph Babinski (1857-1932) described a particular syndrome of adiposity and sexual infantilism in an adolescent with a craniopharyngioma expanding at the base of the brain. This condition of adipose-genital dystrophy, also known as Babinski-Fröhlich syndrome, represented the first clinical evidence that the brain controlled endocrine functions. Adipose-genital dystrophy forms part of infundibulo-tuberal syndrome, which groups the endocrine, metabolic and behavioral disturbances caused by lesions involving the upper neurohypophysis (median eminence) and the adjacent basal hypothalamus (tuber cinereum)...
December 2015: Pituitary
Kai Li, Xiaocheng Lu, Ningning Yang, Jinyu Zheng, Baosheng Huang, Lixin Li
OBJECTIVE: A craniopharyngioma (CP) is a benign tumor commonly considered to originate from the pituitary stalk. However, it is still controversial as to whether the pituitary stalk should be maintained after microsurgery to resect the tumor despite its own physiological function of the pituitary stalk. In this study, meta-analysis was conducted to evaluate the influence of the pituitary stalk resection on endocrine function and tumor recurrence rate. METHODS: The relevant publications were identified by searching databases including Pubmed, Embase, Medline, and Web of Science...
September 2015: Clinical Neurology and Neurosurgery
Jacob M Gump, Andrew M Donson, Diane K Birks, Vladimir M Amani, Karun K Rao, Andrea M Griesinger, B K Kleinschmidt-DeMasters, James M Johnston, Richard C E Anderson, Amy Rosenfeld, Michael Handler, Lia Gore, Nicholas Foreman, Todd C Hankinson
INTRODUCTION: Pediatric adamantinomatous craniopharyngioma (ACP) is a histologically benign but clinically aggressive brain tumor that arises from the sellar/suprasellar region. Despite a high survival rate with current surgical and radiation therapy (75-95 % at 10 years), ACP is associated with debilitating visual, endocrine, neurocognitive and psychological morbidity, resulting in excheptionally poor quality of life for survivors. Identification of an effective pharmacological therapy could drastically decrease morbidity and improve long term outcomes for children with ACP...
2015: Acta Neuropathologica Communications
Kris S Armoogum, Nicola Thorp
BACKGROUND: We compare clinical outcomes of paediatric patients with CNS tumours treated with protons or IMRT. CNS tumours form the second most common group of cancers in children. Radiotherapy plays a major role in the treatment of many of these patients but also contributes to late side effects in long term survivors. Radiation dose inevitably deposited in healthy tissues outside the clinical target has been linked to detrimental late effects such as neurocognitive, behavioural and vascular effects in addition to endocrine abnormalities and second tumours...
2015: Cancers
Christian L Roth, Hedieh Eslamy, David Werny, Clinton Elfers, Michele L Shaffer, Catherine Pihoker, Jeffrey Ojemann, William B Dobyns
OBJECTIVE: Excessive weight gain frequently occurs in patients with hypothalamic tumors and lesions leading to hypothalamic obesity (HO). METHODS: Digital brain magnetic resonance imaging (MRI) and clinical outcomes were studied retrospectively in a single center, including 45 children with postoperative lesions in the sellar region (41 craniopharyngiomas, 4 with Rathke's cleft cysts), ∼5 years post-surgery, mean age 13.9 years. Four standard sections covering hypothalamic areas critical to energy homeostasis were used to assess lesions and calculate a hypothalamic lesion score (HLS); the association with HO was examined...
June 2015: Obesity
Kunal S Patel, Shaan M Raza, Edward D McCoul, Aikaterini Patrona, Jeffrey P Greenfield, Mark M Souweidane, Vijay K Anand, Theodore H Schwartz
OBJECT: Craniopharyngiomas are benign parasellar tumors for which surgical removal, although potentially curative, often leads to morbidity with resulting decreases in quality of life (QOL). The endonasal endoscopic approach is a minimal-access technique for removing these tumors and may reduce postoperative morbidity. The QOL following this method for resection of craniopharyngiomas has not been documented. METHODS: The authors reviewed a database of consecutive endonasal endoscopic surgeries done at Weill Cornell Medical College...
September 2015: Journal of Neurosurgery
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