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https://www.readbyqxmd.com/read/29906576/papillary-tumor-of-the-pineal-region-in-children-presentation-of-a-case-and-comprehensive-literature-review
#1
REVIEW
Joham Choque-Velasquez, Roberto Colasanti, Julio Resendiz-Nieves, Behnam Rezai Jahromi, Olli Tynninen, Juhani Collan, Mika Niemelä, Juha Hernesniemi
The papillary tumor of the pineal region (PTPR) is a rare grade II-III pineal lesion with peculiar histologic and immunohistochemical features. These tumors mostly occur in adults, rarely in children (19 cases reported up to now). We present a 3-year-old boy who was re-operated for a recurrent PTPR (grade II). The gross total resection of the lesion, through an occipital interhemispheric approach in sitting position, was followed by adjuvant radiochemotherapy. Histological examination revealed tumor progression (grade III), and the MIB-1 proliferation index was higher than 25%...
June 12, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29873033/aaa-atpases-reptin-and-pontin-as-potential-diagnostic-and-prognostic-biomarkers-in-salivary-gland-cancer-a-short-report
#2
Jan-Henrik Mikesch, Wolfgang Hartmann, Linus Angenendt, Otmar Huber, Christoph Schliemann, Maria Francisca Arteaga, Eva Wardelmann, Claudia Rudack, Wolfgang E Berdel, Markus Stenner, Inga Grünewald
PURPOSE: Salivary gland cancer (SGC) is a rare and heterogeneous disease with significant differences in recurrence and metastasis characteristics. As yet, little is known about the mechanisms underlying the initiation and/or progression of these diverse tumors. In recent years, the AAA+ ATPase family members Pontin (RuvBL1, Tip49a) and Reptin (RuvBL2, Tip49b) have been implicated in various processes, including transcription regulation, chromatin remodeling and DNA damage repair, that are frequently deregulated in cancer...
June 5, 2018: Cellular Oncology (Dordrecht)
https://www.readbyqxmd.com/read/29869226/role-of-dce-mr-in-predicting-breast-cancer-subtypes
#3
Marco Macchini, Martina Ponziani, Andrea Prochowski Iamurri, Mirco Pistelli, Mariagrazia De Lisa, Rossana Berardi, Gian Marco Giuseppetti
OBJECTIVE: The purpose of this retrospective study is to find a correlation between dynamic contrast-enhanced MR features with histological, immunohistochemical and loco-regional characteristics of breast cancer. MATERIALS AND METHODS: A total of 149 patients with histopathologically confirmed invasive breast carcinoma underwent MR imaging. Histological analysis included: histological features (histological type, necrosis, vascular invasion and Mib-1), immunohistochemical characterization (immunophenotype, receptor status, HER2-neu and grading) and loco-regional characteristics (T and N)...
June 5, 2018: La Radiologia Medica
https://www.readbyqxmd.com/read/29863570/basal-cell-carcinoma-with-matrical-differentiation-report-of-a-new-case-in-a-renal-transplant-recipient-and-literature-review
#4
Jean Kanitakis, Emilie Ducroux, Pauline Hoelt, Rémi Cahen, Denis Jullien
Basal-cell carcinoma with matrical differentiation (BCC-MD) is one of the rarest pathologic variants of basal-cell carcinoma, of which 41 cases have been so far reported in detail. One of them developed in a heart-transplant recipient. We report a new case of BCC-MD occurring in a renal-transplant recipient and review the relevant literature. A 75-year-old white man who had received a renal allograft 7 years ago developed a tumor on the left temple clinically suggestive of basal-cell carcinoma. Microscopically, the tumor associated features typical of basal-cell carcinoma (basaloid lobules with peripheral palisading and clefting) and pilomatricoma (presence of shadow/ghost cells)...
June 1, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29844818/b-cell-lymphoma-2-is-associated-with-advanced-tumor-grade-and-clinical-stage-and-reduced-overall-survival-in-young-chinese-patients-with-colorectal-carcinoma
#5
Jiasheng Wang, Gan He, Qiang Yang, Lian Bai, Bin Jian, Qugang Li, Zhongfu Li
The development of biomarkers that accurately and reliably detect colorectal cancer is a promising approach for colorectal cancer screening. Therefore, the objective of the present study was to evaluate the protein expression of α-methylacyl-CoA racemase (P504S/AMACR), tumor protein p53 (p53), B-cell lymphoma 2 (Bcl-2) and Ki-67/mindbomb E3 ubiquitin protein ligase 1 (MIB-1) in a population of Chinese patients with colorectal carcinoma. Colorectal tumors with matched normal tissue margins were collected from 148 surgical patients, and the demographic and clinical characteristics were collected...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29776970/the-e3-ubiquitin-ligase-mib-1-is-necessary-to-form-the-nuclear-halo-in-caenorhabditis-elegans-sperm
#6
Leslie A Herrera, Daniel A Starr
Unlike the classical nuclear envelope with two membranes found in other eukaryotic cells, most nematode sperm nuclei are not encapsulated by membranes. Instead, they are surrounded by a nuclear halo of unknown composition. How the halo is formed and regulated is unknown. We used forward genetics to identify molecular lesions behind three classical fer (fertilization defective) mutations that disrupt the ultrastructure of the Caenorhabditis elegans sperm nuclear halo. We found fer-2 and fer-4 alleles to be nonsense mutations in mib-1...
May 18, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29750709/classic-vulvar-intraepithelial-neoplasia-with-superimposed-lichen-simplex-chronicus-a-unique-variant-mimicking-differentiated-vulvar-intraepithelial-neoplasia
#7
Jaclyn C Watkins, Eric Yang, Christopher P Crum, Michael Herfs, Tarik Gheit, Massimo Tommasino, Marisa R Nucci
High-grade vulvar intraepithelial neoplasia, a precursor lesion to vulvar squamous cell carcinoma, is subdivided into 2 types, classic or usual vulvar intraepithelial neoplasia (CVIN) and differentiated vulvar intraepithelial neoplasia (DVIN). CVIN, which is a human papilloma virus (HPV)-dependent lesion, is typically distinguished from DVIN, a p53 mutation-dependent process, by its distinct histomorphologic and immunohistochemical characteristics. However, distinguishing between the 2 entities becomes challenging in cases of CVIN with superimposed inflammatory changes, especially lichen simplex chronicus (LSC)...
May 10, 2018: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29706302/the-role-of-proton-beam-therapy-in-central-neurocytoma-a-single-institution-experience
#8
Kylie H Kang, Emily Schapira, Andrzej Niemierko, Maria Martinez-Lage, Marc R Bussière, Torunn I Yock, Jay S Loeffler, William E Butler, Bob S Carter, Helen A Shih
PURPOSE: Central neurocytomas (CNs) are rare World Health Organization grade II tumors managed with surgery and radiation therapy. We report our experience in managing CN with proton beam therapy (PBT) when radiation therapy was used. METHODS AND MATERIALS: We identified 61 patients with pathologically diagnosed CN treated at our institution between 1996 and 2016, of which 24 met inclusion criteria. Patient, tumor, and treatment characteristics are reported in context of progression-free survival and treatment-related adverse events...
February 16, 2018: Practical Radiation Oncology
https://www.readbyqxmd.com/read/29618055/malignancy-index-using-intraoperative-flow-cytometry-is-a-valuable-prognostic-factor-for-glioblastoma-treated-with-radiotherapy-and-concomitant-temozolomide
#9
Taiichi Saito, Yoshihiro Muragaki, Takahiro Shioyama, Takashi Komori, Takashi Maruyama, Masayuki Nitta, Takayuki Yasuda, Junji Hosono, Saori Okamoto, Takakazu Kawamata
BACKGROUND: Intraoperative prediction of radiochemosensitivity is desirable for improving the clinical management of glioblastoma (GBM) patients. We have previously developed an original technique for intraoperative flow cytometry (iFC) and defined a malignancy index (MI). OBJECTIVE: To determine whether MI correlates with prognosis in GBM patients who underwent the standard treatment protocol of radiotherapy and temozolomide administration. METHODS: The current study included 102 patients with GBM that had been newly diagnosed from 2010 to 2015 who underwent our iFC analysis and received the standard treatment protocol...
March 30, 2018: Neurosurgery
https://www.readbyqxmd.com/read/29594352/analysis-of-membranous-ki-67-staining-in-breast-cancer-and-surrounding-breast-epithelium
#10
Gábor Cserni
Membranous Ki-67 staining with the MIB-1 antibody has been described in hyalinising trabecular adenomas of the thyroid and sclerosing haemangiomas of the lung. Its relatively rare occurrence in breast tumours has also been documented. The aim of the present study was to assess the rate of any membranous MIB-1 staining in breast specimens. The staining was performed at room temperature with 1:100 dilution of the antibody. One hundred four core needle biopsies and 41 operative specimens were analysed. Membranous staining was noted in 36/144 invasive carcinomas, 20/42 in situ carcinomas and 46/99 cases of peritumoural benign/normal breast epithelium...
March 28, 2018: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29581891/multifocal-primary-melanoma-of-the-cervical-spinal-cord-successfully-treated-by-tumorectomy-a-case-report
#11
Takahito Iga, Akio Iwanami, Takeru Funakoshi, Shuji Mikami, Osahiko Tsuji, Narihito Nagoshi, Eijiro Okada, Nobuyuki Fujita, Mitsuru Yagi, Kota Watanabe, Masaya Nakamura, Morio Matsumoto
Introduction: Multifocal primary melanoma of the spine is extremely rare. Here, we report a case of multifocal primary melanoma of the cervical spinal cord. Case presentation: A 39-year-old man presented with a 1-year history of numbness of the upper extremities and back. Magnetic resonance imaging of the cervical spine suggested multifocal intradural extramedullary tumors at levels C2 and C4-C5. A diagnostic biopsy revealed a pathological diagnosis of malignant melanoma...
2018: Spinal Cord Series and Cases
https://www.readbyqxmd.com/read/29575197/pttg-1-securin-immunoexpression-in-meningiomas-correlates-with-tumor-grade-and-proliferation-rate-potential-use-as-a-diagnostic-marker-of-malignancy
#12
Alexandros Iliadis, Maria-Aikaterini Virvili, Nicolaos A Flaris, Stavroula Pervana, Elissabet Pazarli, Grigoris Tripsianis, Maria E Grigoriou, Ioannis Efstratiou, Dimitrios N Kanakis
This study essentially aims to contribute to the immunohistochemical investigation of the use of pituitary tumor transforming gene (PTTG) as a marker of cell proliferation or advanced tumor grade in meningiomas of various WHO grades. In all, 51 cases were recovered in total, 21 Grade-I, 23 Grade-II and 7 Grade-III meningiomas. Mitotic index (MI), Ki-67/MiB-1 positivity percentage and PTTG expression were analyzed in correlation to each other as well as to the tumor WHO grades. All three biomarkers showed a high diagnostic significance and a strong association with WHO grades...
April 2018: APMIS: Acta Pathologica, Microbiologica, et Immunologica Scandinavica
https://www.readbyqxmd.com/read/29562481/huge-mucinous-carcinoma-of-the-breast-in-which-doubling-time-was-observed-by-computed-tomography-during-3-years-without-treatment
#13
Bunzo Nakata, Kenji Kuroda, Yasuhiko Yoshida, Nozomi Iimori, Go Masuda, Tomihiro Lee, Masashige Tendo, Takeshi Hori, Hiroshi Sato, Tetsuro Ishikawa
Here we report the case of a 77-year-old woman with a huge cancer of the right breast for which size was measured on computed tomography in our hospital preoperatively and in other hospital 3 years earlier. During the 3-year untreated interval, the tumor grew from 4 cm to 13 cm in maximum diameter, and the tumor-volume doubling time (TVDT) was calculated as 209 days. The patient underwent mastectomy with axillary lymph node dissection, with the large skin defect covered by autologous skin graft. The pathological diagnosis was pure mucinous carcinoma (MC) of the breast with a low MIB-1 index, no vessel invasion, and no lymph node metastasis...
March 16, 2018: Breast Disease
https://www.readbyqxmd.com/read/29533280/polymorphous-sweat-gland-carcinoma-an-immunohistochemical-and-molecular-study
#14
Shira Ronen, Irene Aguilera-Barrantes, Tamara Giorgadze, Petr Šteiner, Petr Grossmann, Saul Suster
Polymorphous sweat gland carcinoma is an uncommon low-grade malignant adnexal tumor with a marked predilection for the distal extremities. Histologically, the lesions are characterized by a cellular proliferation showing a combination of growth patterns, including trabecular, solid, tubular, cribriform, or adenoid cystic and pseudopapillary. The immunohistochemical and molecular profile of these tumors has not yet been properly addressed. We have studied 3 cases of polymorphous sweat gland carcinoma using a broad panel of immunohistochemical markers including cytokeratin AE1/AE3, CK5/6, MOC31, p40, p63, p16, chromogranin, synaptophysin, CD56, MIB-1, estrogen receptor, progesterone receptor, androgen receptor, BER-EP4, smooth muscle actin, epithelial membrane antigen, carcinoembryonic antigen, CD117, S100 protein, HBME-1, DOG1, vimentin, and mammaglobin...
March 6, 2018: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/29531012/mib-1-is-required-for-spermatogenesis-and-facilitates-lin-12-and-glp-1-activity-in-caenorhabditis-elegans
#15
Miriam Ratliff, Katherine L Hill-Harfe, Elizabeth J Gleason, Huiping Ling, Tim L Kroft, Steven W L'Hernault
Covalent attachment of ubiquitin to substrate proteins changes their function or marks them for proteolysis, and the specificity of ubiquitin attachment is mediated by the numerous E3 ligases encoded by animals. Mind Bomb is an essential E3 ligase during Notch pathway signaling in insects and vertebrates. While Caenorhabditis elegans encodes a Mind Bomb homolog ( mib-1 ), it has never been recovered in the extensive Notch suppressor/enhancer screens that have identified numerous pathway components. Here, we show that C...
May 2018: Genetics
https://www.readbyqxmd.com/read/29522936/evaluation-of-dna-ploidy-with-intraoperative-flow-cytometry-may-predict-long-term-survival-of-patients-with-supratentorial-low-grade-gliomas-analysis-of-102-cases
#16
Akane Suzuki, Takashi Maruyama, Masayuki Nitta, Takashi Komori, Soko Ikuta, Mikhail Chernov, Manabu Tamura, Takakazu Kawamata, Yoshihiro Muragaki
OBJECTIVE: The objective of the present study was evaluation of the prognostic significance of DNA ploidy assessed with intraoperative flow cytometry (iFC) during resection of low-grade gliomas (LGG). PATIENTS AND METHODS: Retrospective analysis of 102 consecutive cases of newly diagnosed WHO grade II supratentorial gliomas, surgical removal of which was accompanied by iFC, was done. There were 46 diffuse astrocytomas (DA) and 56 oligodendrogliomas (OD). According to iFC, 68 tumors (67%) were considered non-aneuploid and 34 (33%) aneuploid...
May 2018: Clinical Neurology and Neurosurgery
https://www.readbyqxmd.com/read/29501019/two-stage-resection-of-a-bilateral-pheochromocytoma-and-pancreatic-neuroendocrine-tumor-in-a-patient-with-von-hippel-lindau-disease-a-case-report
#17
Yutaka Endo, Minoru Kitago, Akira Miyajima, Isao Kurihara, Kaori Kameyama, Masahiro Shinoda, Hiroshi Yagi, Yuta Abe, Taizo Hibi, Chisato Takagi, Yutaka Nakano, Wataru Koizumi, Osamu Itano, Yuko Kitagawa
INTRODUCTION: von Hippel-Lindau disease (vHL disease) is a hereditary disease in which tumors and cysts develop in many organs, in association with central nervous system hemangioblastomas, pheochromocytomas, and pancreatic tumors. We herein report a case of vHL disease (type 2A) associated with bilateral pheochromocytomas, pancreatic neuroendocrine tumors (PNET), and cerebellar hemangioblastomas treated via pancreatectomy after adrenalectomy. CASE PRESENTATION: A 51-year-old woman presented with a cerebellar tumor, bilateral hypernephroma, and pancreatic tumor detected during a medical checkup...
2018: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/29489901/impact-of-9p-deletion-and-p16-cyclin-d1-and-myc-hyperexpression-on-the-outcome-of-anaplastic-oligodendrogliomas
#18
Karine Michaud, Marie de Tayrac, Myreille D'Astous, Claudie Paquet, Peter Vincent Gould, Stéphan Saikali
OBJECTIVE: To study the presence of 9p deletion and p16, cyclin D1 and Myc expression and their respective diagnostic and prognostic interest in oligodendrogliomas. METHODS: We analyzed a retrospective series of 40 consecutive anaplastic oligodendrogliomas (OIII) from a single institution and compared them to a control series of 10 low grade oligodendrogliomas (OII). Automated FISH analysis of chromosome 9p status and immunohistochemistry for p16, cyclin D1 and Myc was performed for all cases and correlated with clinical and histological data, event free survival (EFS) and overall survival (OS)...
2018: PloS One
https://www.readbyqxmd.com/read/29480754/spectral-radiance-of-protoporphyrin-ix-fluorescence-and-its-histopathological-implications-in-5-aminolevulinic-acid-guided-surgery-for-glioblastoma
#19
Takashi Yoneda, Naosuke Nonoguchi, Naokado Ikeda, Ryokichi Yagi, Shinji Kawabata, Motomasa Furuse, Yoshinobu Hirose, Hiroko Kuwabara, Yoji Tamura, Yoshinaga Kajimoto, Toshihiko Kuroiwa
OBJECTIVE: This study is intended to objectively clarify the relationship between the fluorescence intensity emitted by protoporphyrin IX (PpIX), which is a metabolite of 5-aminolevulinic acid (ALA), and histological findings during glioblastoma surgery. BACKGROUND: ALA is widely used for the intraoperative detection of tumors. There are several reports about the fluorescence of PpIX and the histological findings of tumors, but judgments about the fluorescence intensity depend largely on the subjective sense of each surgeon...
May 2018: Photomedicine and Laser Surgery
https://www.readbyqxmd.com/read/29394575/-a-case-of-breast-carcinoma-associated-with-osteoclast-like-giant-cells
#20
Masaru Noda, Kazunoshin Tachibana, Hiroshi Nakano, Sadahiko Abe, Yuko Murakami, Maiko Okano, Noriko Abe, Sayaka Yoshida, Yuichiro Kiko, Yuko Hashimoto, Tohru Ohtake
Mammary carcinoma with osteoclast-like giant cells is uncommon, and its onset mechanism and malignancy are unknown. We report a case of mammary carcinoma with osteoclast-like giant cells. A 41-year-old woman noticed a lump in her left breast. Ultrasound sonography findings suggested breast cancer. A core needle biopsy revealed invasive ductal carcinoma of the breast. Modified radicalmastectomy and sentinell ymph node biopsy were performed. Histopathologicalexamination revealed papillotubular carcinoma with osteoclast-like giant cells...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
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