Gray Umbach, Edwina B Tran, Charlotte D Eaton, Abrar Choudhury, Ramin Morshed, Javier E Villanueva-Meyer, Philip V Theodosopoulos, Stephen T Magill, Michael W McDermott, David R Raleigh, Ezequiel Goldschmidt
BACKGROUND AND OBJECTIVES: Meningiomas are the most common primary intracranial tumors and are among the only tumors that can form lamellar, hyperostotic bone in the tumor microenvironment. Little is known about the epidemiology or molecular features of hyperostotic meningiomas. METHODS: Using a retrospective database of 342 meningiomas treated with surgery at a single institution, we correlated clinical, tumor-related, targeted next-generation DNA sequencing (n = 39 total, 16 meningioma-induced hyperostosis [MIH]), and surgical variables with the presence of MIH using generalized linear models...
January 8, 2024: Operative Neurosurgery (Hagerstown, Md.)