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https://www.readbyqxmd.com/read/29394575/-a-case-of-breast-carcinoma-associated-with-osteoclast-like-giant-cells
#1
Masaru Noda, Kazunoshin Tachibana, Hiroshi Nakano, Sadahiko Abe, Yuko Murakami, Maiko Okano, Noriko Abe, Sayaka Yoshida, Yuichiro Kiko, Yuko Hashimoto, Tohru Ohtake
Mammary carcinoma with osteoclast-like giant cells is uncommon, and its onset mechanism and malignancy are unknown. We report a case of mammary carcinoma with osteoclast-like giant cells. A 41-year-old woman noticed a lump in her left breast. Ultrasound sonography findings suggested breast cancer. A core needle biopsy revealed invasive ductal carcinoma of the breast. Modified radicalmastectomy and sentinell ymph node biopsy were performed. Histopathologicalexamination revealed papillotubular carcinoma with osteoclast-like giant cells...
November 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/29378347/extraventricular-neurocytoma-in-the-left-frontal-lobe-a-case-report-and-literature-review
#2
Fan Chen, Rihua Jin, Xinmin Wu, Zengping Dong, Dawei Chen
BACKGROUND: Neurocytoma is a rare brain neoplasm of neuroepithelial origin that predominantly occurs in the ventricular system adjacent to the interventricular foramen and septum pellucidum. However, extraventricular neurocytoma is an extremely rare entity with poor clinical, radiological, and histopathological characterization. Herein, we report a case of an extraventricular parafalcine neurocytoma in the left frontal lobe. OBJECTIVES: This study will compile and examine reported cases of extraventricular neurocytoma in an attempt to provide an up-to-date summary of the condition...
January 25, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29354850/c11orf95-rela-fusions-and-upregulated-nf-kb-signalling-characterise-a-subset-of-aggressive-supratentorial-ependymomas-that-express-l1cam-and-nestin
#3
Prit Benny Malgulwar, Aruna Nambirajan, Pankaj Pathak, Mohammed Faruq, Madhu Rajeshwari, Manmohan Singh, Vaishali Suri, Chitra Sarkar, Mehar Chand Sharma
Ependymomas (EPN) show site specific genetic alterations and a recent DNA methylation profiling study identified nine molecular subgroups. C11orf95-RELA and YAP1 fusions characterise the RELA and YAP1 molecular subgroups, respectively, of supratentorial (ST)-EPNs. Current guidelines recommend molecular subgrouping over histological grade for accurate prognostication. Clinicopathological features of ST-EPNs in correlation with C11orf95-RELA and YAP1 fusions have been assessed in only few studies. We aimed to study these fusions in EPNs, and identify diagnostic and prognostic markers...
January 22, 2018: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29344143/function-of-cell-cycle-regulators-in-predicting-silent-pituitary-adenoma-progression-following-surgical-resection
#4
Sung Hyun Park, Ji Hwan Jang, Young Min Lee, Joon Soo Kim, Kyu Hong Kim, Young Zoon Kim
The present study investigated the use of cell-cycle regulators for predicting the progression of silent pituitary adenoma (SPA) following surgical resection, via immunohistochemical analysis of tumor samples obtained by surgical resection. The medical records of patients diagnosed with SPA between January 2000 and December 2013 in the Samsung Changwon Hospital, Sungkyunkwan University School of Medicine (Changwon, South Korea) were reviewed. Immunohistochemical staining was performed on sections of the archived, paraffin-embedded tissues obtained by surgery, with all tissues stained for cell-cycle regulatory proteins p16, p15, p21, cyclin-dependent kinase (CDK)4, CDK6, retinoblastoma protein (pRb) and cyclin D1, as well as E3 ubiquitin-protein ligase mib1 (MIB-1) antigen and p53...
December 2017: Oncology Letters
https://www.readbyqxmd.com/read/29325939/liponeurocytoma-of-the-cerebello-pontine-angle
#5
Carmela Chiaramonte, Sylvain Rabaste, Timothee Jacquesson, David Meyronet, François Cotton, Emmanuel Jouanneau, Moncef Berhouma
Liponeurocytoma is a very rare tumor classified as grade II (neuronal and mixed neuronal-glial tumors) according to 2016 WHO classification of Tumors of the Central Nervous System. The median age is 50-years-old and the most frequent location is the posterior cranial fossa especially within the cerebellar hemispheres; those arising in the cerebellopontine angle are exceptional. We herein report the clinical, radiological and pathological characteristics of a cerebellopontine angle liponeurocytoma in a 35-year-old woman...
January 8, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29322978/chromosomal-aberrations-in-chordoid-meningioma-an-analysis
#6
Harsha Sugur, Arun H Shastry, Nishant Sadashiva, Dwarakanath Srinivas, Vani Santosh, Sampath Somanna
INTRODUCTION: Chordoid meningiomas (CMs) are a rare subgroup of tumors, accounting for approximately 0.5% of all meningiomas. These tumors correspond to World Health Organization (WHO) Grade II lesions and behave aggressively, with an increased likelihood of recurrence. There are only two studies that have described the genetic alterations in CMs. While a majority of meningiomas are known to have deletion at many chromosomal loci such as 22q, 18p, 14q, and 1p, which are found to be associated with initiation, progression, and malignancy of these tumors, these have not yet been studied in CMs...
January 2018: Neurology India
https://www.readbyqxmd.com/read/29316326/orthopedia-homeobox-is-preferentially-expressed-in-typical-carcinoids-of-the-lung
#7
Krisztina Z Hanley, Zachary J Dureau, Cynthia Cohen, Dong M Shin, Taofeek K Owonikoko, Gabriel L Sica
BACKGROUND: Twenty-seven percent of neuroendocrine tumors (NETs) are associated with distant metastases, and in some patients, the primary site is unknown. Orthopedia homeobox protein (OTP) has been described as a useful marker for lung carcinoids (LCs) and for separating low-grade typical carcinoids (TCs) from intermediate-grade atypical carcinoids (ACs) in resection specimens. This study evaluated OTP, thyroid transcription factor 1 (TTF-1), and Ki-67 expression in fine-needle aspiration (FNA) samples of various NETs...
January 9, 2018: Cancer
https://www.readbyqxmd.com/read/29312841/degree-of-resection-and-ki-67-labeling-index-for-recurring-meningiomas
#8
Richard Menger, David E Connor, Alvin Y Chan, Gary Jain, Anil Nanda
Objective Meningioma recurrence after resection is likely influenced by multiple surgical and histologic factors. In this study, the degree of resection and tumor immunoreactivity to MIB-1 (i.e., Ki-67 labeling index (LI)) are described in recurrent and non-recurrent meningioma cases. Methods Data regarding tumor location, the degree of resection, histologic features, and the degree of Ki-67 positivity were collected for 32 patients treated between September 2008 and July 2009. Follow-up for recurrence was assessed through five years...
November 3, 2017: Curēus
https://www.readbyqxmd.com/read/29287310/high-grade-transformation-dedifferentiation-of-an-adenoid-cystic-carcinoma-of-the-minor-salivary-gland-to-myoepithelial-carcinoma
#9
So Tando, Toshitaka Nagao, Kaori Kayano, Shinji Fushiki, Kyoko Itoh
High-grade transformation (HGT)/dedifferentiation is an unusual phenomenon in salivary gland carcinomas. Here we report a case of adenoid cystic carcinoma (ACC) with HGT/dedifferentiation to myoepithelial carcinoma, occurring in the epipharynx of a 42-year-old woman. The surgically resected tumor was a pedunculated mass, 31 × 25 mm in size, which had two histologically distinct carcinomatous areas, including a high-grade sarcomatoid area composed of pleomorphic spindle cells and an area consisting of low-grade typical ACC...
December 29, 2017: Pathology International
https://www.readbyqxmd.com/read/29246159/prognostic-value-of-mib-1-proliferation-index-in-solitary-fibrous-tumors-of-the-pleura-implemented-in-a-new-score-a-multicenter-study
#10
Matthias Diebold, Alex Soltermann, Selma Hottinger, Sarah R Haile, Lukas Bubendorf, Paul Komminoth, Wolfram Jochum, Rainer Grobholz, Dirk Theegarten, Sabina Berezowska, Kaid Darwiche, Filiz Oezkan, Malcolm Kohler, Daniel P Franzen
BACKGROUND: Although the majority of solitary fibrous tumors of the pleura (SFTP) follow a benign course, 10-25% of patients suffer from recurrence or metastatic disease. Several scoring models have been proposed to predict the outcome. However, none of these included immunohistochemical (IHC) markers as possible prognosticators. METHODS: In this multicenter study, we collected clinical data and formalin-fixed and paraffin-embedded (FFPE) tissue blocks of patients with histologically proven SFTP which had been surgically resected between 2000 und 2015...
December 16, 2017: Respiratory Research
https://www.readbyqxmd.com/read/29200961/posterior-cerebral-fossa-medulloepithelioma-report-of-a-case
#11
Nezha Oumghar, Fatima Ezzahra Hazmiri, Abdelhamid El Omrani, Hanane Rais, Mouna Khouchani
Background: Medulloepithelioma is a rare primitive neuroectodermal tumor of the central nervous system, usually developing in childhood. Due to its rarity, the optimal management is still unknown. The prognosis is poor, especially when resection is incomplete. Adjuvant radiochemotherapy is often indicated. Case presentation: We report a rare case of infratentorial medulloepithelioma in a 3 year old girl. She presented symptoms of increased intracranial pressure...
2017: BMC Clinical Pathology
https://www.readbyqxmd.com/read/29200888/prognostic-and-clinicopathological-value-of-ki-67-mib-1-expression-in-renal-cell-carcinoma-a-meta-analysis-based-on-4579-individuals
#12
Zhun Wang, Hui Xie, Linpei Guo, Qiliang Cai, Zhiqun Shang, Ning Jiang, Yuanjie Niu
Background: Previous studies have investigated the prognostic significance of Ki-67/MIB-1 expression in renal cell carcinoma (RCC), however, the reports are controversial and inconsistent. This study aimed to investigate Ki-67/MIB-1 expression in RCC and its correlation with prognosis and clinicopathological features. Methods: We searched relevant studies that reported associations between Ki-67/MIB-1 expression and prognosis in RCC from PubMed, Embase, Web of Science, and Cochrane Library studies published until April 14, 2017...
2017: Cancer Management and Research
https://www.readbyqxmd.com/read/29199205/re-evaluation-of-mib-1-immunostaining-for-diagnosing-hyalinizing-trabecular-tumour-of-the-thyroid-semi-automated-techniques-with-manual-antigen-retrieval-are-more-accurate-than-fully-automated-techniques
#13
Nami Takada, Mitsuyoshi Hirokawa, Chiho Ohbayashi, Takeshi Nishikawa, Tomoo Itoh, Naoko Imagawa, Tetsunari Oyama, Tadashi Handa, Tadashi Hasegawa, Shintaro Sugita, Akiko Murata, Akira Miyauchi
Hyalinizing trabecular tumour (HTT) immunohistochemically shows cell membranous immunoreactivity for MIB-1. This aberrant immunoreactivity is an important factor for the diagnosis of HTT. However, fully automated stainers frequently fail to confirm the immunoreactivity. The aim of this study is to investigate the cause of false negative cell membranous immunoreactivity for MIB-1 in HTT using fully automated stainers, to determine potential reasons for the problem, and to establish methods confirming cell membranous immunoreactivity for MIB-1 in HTT...
December 2, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/29170844/early-recognition-of-aggressive-pituitary-adenomas-a-single-centre-experience
#14
Filippo Ceccato, Daniela Regazzo, Mattia Barbot, Luca Denaro, Enzo Emanuelli, Daniele Borsetto, Giuseppe Rolma, Luigi Alessio, Marina Paola Gardiman, Giuseppe Lombardi, Nora Albiger, Domenico D'Avella, Carla Scaroni
BACKGROUND: Pituitary adenomas are usually considered benign tumours, although some of them can exhibit an aggressive behaviour. Patients with clinically aggressive pituitary adenomas are frequently diagnosed with larger masses, and may present an earlier recurrence (or persistence) after surgery. Our aim was to characterise the clinical, histopathological and radiological features of patients with aggressive pituitary adenoma, in order to correlate their clinical behaviour with the response to treatment plan...
January 2018: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29168109/a-case-of-glomangiopericytoma-at-the-nasal-septum
#15
Takashi Anzai, Tsuyoshi Saito, Sho Tsuyama, Miri Toh, Katsuhisa Ikeda, Shin Ito
Glomangiopericytoma (GPC) is a rare sinonasal perivascular tumor that accounts for < 0.5-1% of all sinonasal tumors. GPC is categorized as a low-grade neoplasm with borderline malignancy and a tendency of local recurrence. GPC is a rare mesenchymal neoplasm characterized by the perivascular proliferation of tumor cells, and it requires being distinguished from solitary fibrous tumors. Here, we report a case of GPC in a 68-year-old male patient who presented at the emergency room of our hospital with a complaint of sudden epistaxis...
November 22, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/29158006/vdr-independent-induction-of-acid-sphingomyelinase-by-1-23-oh-2-d3-in-gastric-cancer-cells-impact-on-apoptosis-and-cell-morphology
#16
Elisabetta Albi, Samuela Cataldi, Ivana Ferri, Angelo Sidoni, Giovanna Traina, Katia Fettucciari, Francesco Saverio Ambesi-Impiombato, Andrea Lazzarini, Francesco Curcio, Maria Rachele Ceccarini, Tommaso Beccari, Michela Codini
1 alpha,25-dihydroxyvitamin D3 (1,23(OH)2 D3) is known to play a dual role in cancer, by promoting or inhibiting carcinogenesis via 1,23(OH)2 D3 receptor (VDR) and phosphatase and tensin homolog deleted on chromosome 10 (PTEN). Fok I polymorphism of VDR may indirectly influence the receptor levels through autoregulation. The involvement of neutral sphingomyelinase in the non-classic VDR-mediated genomic pathway response to 1,23(OH)2 D3 treatment has been reported. Until now no information were reported about Fok I polymorphism of VDR in NCI-N87 human gastric cancer cells and the relation between acid sphingomyelinase and 1,23(OH)2 D3...
November 17, 2017: Biochimie
https://www.readbyqxmd.com/read/29147864/impact-of-who-2016-update-of-brain-tumor-classification-molecular-markers-and-clinical-outcomes-in-pleomorphic-xanthoastrocytoma
#17
Raees Tonse, Tejpal Gupta, Sridhar Epari, Jayant Goda Shastri, Mamta Gurav, Nazia Bano, Rakesh Jalali
We present outcomes of pleomorphic xanthoastrocytoma (PXA) and correlate the impact of clinical, pathologic and molecular markers. Between 2006 and 2016, 37 patients with histologically verified PXA form the study cohort. All underwent maximal safe resection; those who had good resection and young age were observed. Adjuvant radiotherapy was given in patients with some atypical features such as high MIB-1 index (> 5%), residual disease or at recurrence. Patients with anaplastic PXA were administered adjuvant radiotherapy and systemic therapy...
November 16, 2017: Journal of Neuro-oncology
https://www.readbyqxmd.com/read/29138702/a-case-of-c5-vertebral-chordoma-in-a-73-year-old-patient-with-more-than-8-years-of-follow-up-after-total-piecemeal-spondylectomy
#18
Keigo Tanaka, Harutoshi Sakakima, Kazutoshi Hida, Kanako Hatanaka, Kosei Ijiri
Chordoma arising from the cervical spine is rare and the traditional long-term prognosis is typically poor. Total en bloc spondylectomy with a wide margin is generally accepted to be the most appropriate management for thoracic and lumbar malignant tumors. However, this method is still challenging for the cervical spine because of the proximity of the tumor to the vertebral arteries and neural elements. Here, we report a 73-year-old man with a C5 vertebral chordoma treated with total piecemeal spondylectomy...
2017: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/29134440/ki67-labeling-index-assessment-and-prognostic-role-in-gastroenteropancreatic-neuroendocrine-neoplasms
#19
REVIEW
Günter Klöppel, Stefano La Rosa
In 1983, a monoclonal antibody, Ki67, was generated, that labeled the nuclei of proliferating non-neoplastic and neoplastic cells. The name Ki67 derived from the city of Kiel (Ki) where the antibody was produced in the university department of pathology and refers to the number of the original clone (67). Systematic assessment of the proliferative activity of tumors using Ki67 started in the 1990s, when Ki67, which only worked on frozen tissue, was complemented by the antibody MIB-1 that also worked in formalin-fixed tissues...
November 13, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29098034/asa404-a-vascular-disrupting-agent-as-an-experimental-treatment-approach-for-brain-tumors
#20
Oliver Bähr, Stefanie Gross, Patrick N Harter, Elmar Kirches, Christian Mawrin, Joachim P Steinbach, Michel Mittelbronn
Malignant brain tumors, including gliomas, brain metastases and anaplastic meningiomas, are associated with poor prognosis, and represent an unmet medical need. ASA404 (DMXAA), a vascular disrupting agent, has demonstrated promising results in several preclinical tumor models and early phase clinical trials. However, two phase III trials in non-small cell lung cancer reported insufficient results. The aim of the present study was to determine the effects of ASA404 on brain tumors. The effects of ASA404 were evaluated in vitro and in vivo using subcutaneous, and orthotopical models for malignant glioma (U-87, LN-229, U-251, LN-308 and Tu-2449), brain metastasis (HT-29) and malignant meningioma (IOMM-Lee)...
November 2017: Oncology Letters
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