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https://www.readbyqxmd.com/read/28598278/atypical-pituitary-adenoma-a-clinicopathologic-case-series
#1
Martin J Rutkowski, Ryan M Alward, Rebecca Chen, Jeffrey Wagner, Arman Jahangiri, Derek G Southwell, Sandeep Kunwar, Lewis Blevins, Han Lee, Manish K Aghi
OBJECTIVE In 2004, the WHO classified atypical pituitary adenoma as a distinct adenoma subtype. However, the clinical significance of this distinction remains undetermined. The authors sought to define patient characteristics, tumor features, and treatment outcomes associated with atypical pituitary adenoma. METHODS The authors reviewed records of patients who underwent resection of pituitary adenoma at the University of California, San Francisco, between 2007 and 2014. Per institutional protocol, adenomas exhibiting mitotic activity underwent evaluation for all 3 markers of atypicality (mitotic index, extensive p53 staining, and MIB-1 index ≥ 3%)...
June 9, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28592757/hiv-negative-plasmablastic-lymphoma-attaining-sustained-remission-with-bortezomib-combined-dose-adjusted-epoch-therapy
#2
Hiroyuki Kobayashi, Norito Miyagi
A 61-year-old, HIV-negative, immunocompetent woman was admitted to our hospital for significant weight loss, painful swelling of her right cheek, and rapid growth of a tumor in the right hard palate. A CT scan revealed a neoplastic lesion in the right maxillary sinus, extending to the surrounding soft bone tissue and oral cavity, as well as multiple osteolytic lesions in the skull. A pathologic examination revealed that the neoplastic cells in the oral cavity were plasmablasts tending to appear as differentiated plasma cells...
2017: [Rinshō Ketsueki] the Japanese Journal of Clinical Hematology
https://www.readbyqxmd.com/read/28573325/implications-of-the-world-health-organization-definition-of-atypia-on-surgically-treated-functional-and-non-functional-pituitary-adenomas
#3
Sauradeep Sarkar, Vinu Joe Philip, Sai Kiran Cherukuri, Ari George Chacko, Geeta Chacko
BACKGROUND: The World Health Organization (WHO) defines atypical pituitary adenomas as tumours with a MIB-1 labelling index ≥3%, p53 positivity and increased mitotic activity. Although a few reports have described the clinical and radiological correlates of atypia in pituitary adenomas, its impact on postoperative outcomes is not clearly defined. METHOD: We reviewed preoperative and postoperative records of patients undergoing surgery for pituitary adenomas. Postoperative outcomes for functional adenomas (FPAs) were assessed according to contemporary definitions of remission and recurrence...
June 1, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/28567708/clinical-value-of-fluorine-18%C3%AE-methyltyrosine-pet-in-patients-with-gliomas-comparison-with-fluorine-18-fluorodeoxyglucose-pet
#4
Keishi Horiguchi, Masahiko Tosaka, Tetsuya Higuchi, Yukiko Arisaka, Kenichi Sugawara, Junko Hirato, Hideaki Yokoo, Yoshito Tsushima, Yuhei Yoshimoto
BACKGROUND: We investigated the relationship between metabolic activity and histological features of gliomas using fluorine-18α-methyltyrosine ((18)F-FAMT) positron emission tomography (PET) compared with fluorine-18 fluorodeoxyglucose ((18)F-FDG) PET in 38 consecutive glioma patients. The tumor to normal brain ratios (T/N ratios) were calculated, and the relationships between T/N ratio and World Health Organization tumor grade or MIB-1 labeling index were evaluated. The diagnostic values of T/N ratios were assessed using receiver operating characteristic (ROC) curve analyses to differentiate between high-grade gliomas (HGGs) and low-grade gliomas (LGGs)...
December 2017: EJNMMI Research
https://www.readbyqxmd.com/read/28548702/p16-loss-and-e2f-cell-cycle-deregulation-in-infant-posterior-fossa-ependymoma
#5
Seth C Lummus, Andrew M Donson, Katherine Gowan, Kenneth L Jones, Rajeev Vibhakar, Nicholas K Foreman, B K Kleinschmidt-DeMasters
BACKGROUND: Posterior fossa (PF) ependymomas (EPNs) in infants less than 1 year of age (iEPN-PF) have a poorer clinical outcome than EPNs in older children. While radiation therapy is the standard of care for the latter, it is withheld in infants to avoid neurotoxicity to immature brain. It is unknown whether the adverse outcome in iEPN-PFs is due to treatment differences or aggressive biology. We examined this question using molecular profiling. METHODS: Six anaplastic iEPN-PFs were subjected to transcriptomic analysis and FISH for p16 loss and gains of 1q, and compared with anaplastic PF EPNs from older children...
May 26, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28512040/meningiomas-adjacent-to-major-venous-sinuses-clinical-outcome-and-recurrence
#6
Judith Anthofer, Rahel Seidel-Schulz, Alexander Brawanski, Karl-Michael Schebesch
INTRODUCTION: Surgical treatment of meningiomas next to venous sinuses is difficult because of their irregular growth patterns and infiltration into the venous sinuses, therefore making gross total resection impossible in some patients. In this study, we evaluated the postoperative clinical and neurological course of this tumor subgroup. METHODS: This study included 141 consecutive patients with meningioma located within 20 mm to a major venous sinus. We reviewed patient charts and surgical reports for demographics, histology, and clinical and neurological performance pre- and postoperatively and during follow-up...
May 13, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28469969/vessel-morphometric-parameters-correlation-with-histologic-grade-and-vegf-expression-in-oligodendroglioma
#7
Leah B Strickland-Marmol, Steven Brem, Amyn M Rojiani, Mumtaz V Rojiani
The contributions of histologic features including microvascular proliferation to the determination of malignancy in oligodendrogliomas remain uncertain. We have retrospectively performed morphometric assessments in 20 tumors histologically classified as well-differentiated (WHO Grade II, n=8) or anaplastic (WHO Grade III, n=12) oligodendrogliomas (WDO or AO). Quantitative studies utilized image analysis of double immunolabeled vasculature with anti CD34 with VIP chromogen (purple) and proliferating nuclei with anti MIB-1, using DAB (brown)...
2017: American Journal of Cancer Research
https://www.readbyqxmd.com/read/28430038/prognostic-implications-of-the-subcellular-localization-of-survivin-in-glioblastomas-treated-with-radiotherapy-plus-concomitant-and-adjuvant-temozolomide
#8
Taiichi Saito, Kazuhiko Sugiyama, Yukio Takeshima, Vishwa Jeet Amatya, Fumiyuki Yamasaki, Takeshi Takayasu, Ryo Nosaka, Yoshihiro Muragaki, Takakazu Kawamata, Kaoru Kurisu
OBJECTIVE Currently, the standard treatment protocol for patients with newly diagnosed glioblastoma (GBM) includes surgery, radiotherapy, and concomitant and adjuvant temozolomide (TMZ). Various prognostic biomarkers for GBM have been described, including survivin expression. The aim of this study was to determine whether the subcellular localization of survivin correlates with GBM prognosis in patients who received the standard treatment protocol. METHODS The authors retrospectively examined the subcellular localization of survivin (nuclear, cytoplasmic, or both) using immunohistochemistry in 50 patients with GBM who had received the standard treatment...
April 21, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28423698/parameters-of-simultaneous-18f-fdg-pet-mri-predict-tumor-stage-and-several-histopathological-features-in-uterine-cervical-cancer
#9
Alexey Surov, Hans Jonas Meyer, Stefan Schob, Anne-Kathrin Höhn, Kristina Bremicker, Marc Exner, Patrick Stumpp, Sandra Purz
The purpose of this study was to analyze associations between apparent diffusion coefficient (ADC) and standardized uptake values (SUV) values and different histopathological parameters in uterine cervical cancer. 21 patients with primary uterine cervical cancer were involved into the study. All patients underwent a whole body simultaneous18F-FDG PET/MRI. Mean and maximum SUV were noted (SUVmean and SUVmax). In all tumors minimal, mean, and maximal ADC values (ADCmin, ADCmean, and ADCmax) were estimated. Combined parameters were calculated: SUVmax/SUVmean, ADCmin/ ADCmean, SUVmax/ADCmin and SUVmax/ADCmean...
April 25, 2017: Oncotarget
https://www.readbyqxmd.com/read/28410600/primary-adrenal-non-hodgkin-lymphoma-a-case-report-and-review-of-the-literature
#10
Nanik Ram, Owais Rashid, Saad Farooq, Imran Ulhaq, Najmul Islam
BACKGROUND: Lymphomas are cancers that arise from the white blood cells and have been traditionally divided into two large subtypes: Hodgkin and non-Hodgkin lymphoma. B-cell lymphoma is the most common subtype of non-Hodgkin lymphoma; almost 85% of patients with lymphoma have this variant. Lymphomas can potentially arise from any lymphoid tissue located in the body; however, primary adrenal non-Hodgkin lymphoma is extremely rare. We report the history, examination findings, and laboratory results of a 50-year-old man diagnosed with a primary left adrenal diffuse large B-cell lymphoma...
April 15, 2017: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/28387066/calcifying-pseudoneoplasm-of-the-neuraxis-in-direct-continuity-with-a-low-grade-glioma-a-case-report-and-review-of-the-literature
#11
Nayuta Higa, Hideaki Yokoo, Hirofumi Hirano, Hajime Yonezawa, Tatsuki Oyoshi, Yuko Goto, Kazunori Arita
Calcifying pseudoneoplasms of the neuraxis (CAPNON) are presumed to be a non-neoplastic reactive pathology, based on the frequent finding of granulomatous inflammation. To our knowledge, there are few reports of CAPNON in association with a neoplasm. Here, we report the case of a 62-year-old man presenting with headache, which was caused by CAPNON in the left cingulate gyrus. CT scan revealed a calcified mass exhibiting gradual growth and increasing peritumoral edema. MRI showed an intra-axial hypointense mass on T1- and T2-weighted images...
April 7, 2017: Neuropathology: Official Journal of the Japanese Society of Neuropathology
https://www.readbyqxmd.com/read/28384868/diagnostic-and-prognostic-significance-of-ki-67-immunohistochemical-expression-in-surface-epithelial-ovarian-carcinoma
#12
Asha Mahadevappa, Shruthi Mysore Krishna, Manjunath Gubbanna Vimala
INTRODUCTION: The Surface Epithelial Ovarian Carcinoma (SEOC) at the moment of diagnosis, the disease is extended beyond the structures of the pelvis. Ki-67 is one of the prognostic marker which determines the growth fraction of a tumour and its over expression is associated with malignancy, tumour aggression, reserved prognosis and metastasis. AIM: To evaluate the proliferative activity using Ki-67 immuno-staining in SEOC and to correlate with histological subtype, grade, Federation of Gynecology and Obstetrics (FIGO) stage, CA125 levels for diagnostic and prognostic purpose...
February 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28379477/strong-fgfr3-staining-is-a-marker-for-fgfr3-fusions-in-diffuse-gliomas
#13
Kirsi J Granberg, Matti Annala, Birgitta Lehtinen, Juha Kesseli, Joonas Haapasalo, Pekka Ruusuvuori, Olli Yli-Harja, Tapio Visakorpi, Hannu Haapasalo, Matti Nykter, Wei Zhang
Background.: Inhibitors of fibroblast growth factor receptors (FGFRs) have recently arisen as a promising treatment option for patients with FGFR alterations. Gene fusions involving FGFR3 and transforming acidic coiled-coil protein 3 (TACC3) have been detected in diffuse gliomas and other malignancies, and fusion-positive cases have responded well to FGFR inhibition. As high FGFR3 expression has been detected in fusion-positive tumors, we sought to determine the clinical significance of FGFR3 protein expression level as well as its potential for indicating FGFR3 fusions...
April 1, 2017: Neuro-oncology
https://www.readbyqxmd.com/read/28370387/spindle-cell-squamous-cell-carcinoma-arising-in-bowen-s-disease-case-report-and-review-of-the-published-work
#14
Toshiaki Kogame, Hirotsugu Tanimura, Sei Nakamaru, Kaoru Makimura, Hiroyuki Okamoto, Takahiro Kiyohara
A 79-year-old Japanese woman presented with an ulcerated, brown-red nodule in the center of a sharply demarcated, tan-brown plaque situated on the left side of her right breast. Histologically, the plaque demonstrated an acanthosis with an intraepidermal epithelioma of Borst-Jadassohn. Small oval nests of bland-appearing basophilic cells in the periphery gradually enlarged into nests of various sizes and irregular shapes, composed of densely cohesive, atypical basophilic cells above the central nodule. The atypical keratinocytes shifted to atypical spindle cells beneath the acanthotic epidermis, penetrating deep into the subcutaneous tissue...
March 31, 2017: Journal of Dermatology
https://www.readbyqxmd.com/read/28362240/microvascularization-of-grade-i-meningiomas-effect-on-tumor-volume-blood-loss-and-patient-outcome
#15
Michael Karsy, Brian Burnett, Antonio Di Ieva, Michael D Cusimano, Randy L Jensen
OBJECTIVE Quantitative assessment of tumor microvascularity has the potential to improve prognostication, advance understanding of tumor biology, and help narrow potential molecular therapies. While the role of tumor microvascularity has been widely studied in meningiomas, this study examines both the role of automated measurements and the impact on surgical outcome. METHODS Two hundred seven patients with Grade I meningiomas underwent surgery between 1996 and 2011. Tissue samples from each patient were retrospectively evaluated for histopathological measures of microvascularity, including staining for von Willebrand factor (vWF), CD31, CD105, hypoxia-inducible factor 1 (HIF-1), vascular endothelial growth factor, glucose transporter 1, and carbonic anhydrase IX...
March 31, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28356692/ameloblastic-fibroma-or-fibrosarcoma-a-dilemma-of-oral-surgeon
#16
Nitin Verma, Neha
Ameloblastic fibroma (AF) is an uncommon true mixed odontogenic tumor, with a relative frequency between 1.5% and 4.5% of all odontogenic tumors. It may behave either as a true neoplasm or as a hamartomatous proliferation of odontogenic epithelium of the enamel organ and odontogenic mesenchyme of the primitive dental pulp. Frequently diagnosed between the first and second decades of life with 75% of cases was diagnosed before the age of 20 and present with a well-defined unilocular or multilocular radiolucencies...
July 2016: National Journal of Maxillofacial Surgery
https://www.readbyqxmd.com/read/28353387/recent-developments-in-surgical-pathology-of-the-uterine-corpus
#17
REVIEW
Krisztina Z Hanley, George G Birdsong, Marina B Mosunjac
There have been several updates recently on the classification of uterine tumors. Endometrial carcinomas have traditionally been divided into 2 types, but some are difficult to classify and do not fit readily into either of the currently recognized categories. The Cancer Genome Atlas Research Network has recently defined 4 new categories of endometrial cancer on the basis of mutational spectra, copy number alteration, and microsatellite instability, which might provide independent prognostic information beyond established risk factors...
April 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/28350689/spheno-orbital-meningiomas-an-analysis-based-on-world-health-organization-classification-and-ki-67-proliferative-index
#18
Irina Belinsky, Ann P Murchison, James J Evans, David W Andrews, Christopher J Farrell, James P Casey, Mark T Curtis, Kamila A Nowak Choi, Maria Werner-Wasik, Jurij R Bilyk
PURPOSE: To evaluate the clinical behavior of spheno-orbital meningiomas with regard to World Health Organization (WHO) tumor grade and Ki-67, a cellular marker of proliferation. METHODS: A retrospective review over a 16-year period of the demographic, clinical, radiographic, and surgical data of all patients with spheno-orbital meningioma who underwent surgical resection. Tumor specimens were examined histologically using the current WHO 2016 classification and immunohistochemically using Ki-67/MIB-1 monoclonal antibody...
March 27, 2017: Ophthalmic Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28301542/dna-topoisomerase-ii%C3%AE-and-mitosin-expression-predict-meningioma-recurrence-better-than-histopathological-grade-and-mib-1-after-initial-surgery
#19
Theo L Winther, Sverre H Torp
BACKGROUND: The 2016 WHO histopathological grade or conventional biomarker MIB-1 is insufficient for predicting meningioma recurrence after initial treatment and alternative strategies are required. In this study, we investigated whether DNA topoisomerase IIα and/or mitosin expression can predict tumor recurrence with greater accuracy than conventional methods. METHODS: The expression of MIB-1, topoisomerase IIα, and mitosin were determined as proliferation indices in tissue microarrays using immunohistochemistry...
2017: PloS One
https://www.readbyqxmd.com/read/28270171/brca1-expression-proliferative-and-apoptotic-activities-in-ovarian-epithelial-inclusions
#20
Yiying Wang, Yue Wang, Li Wei, Shuhui Hong, Miaoqing Zhao, Xi Zhang, Wenxin Zheng
BACKGROUND: The purpose of this study was to examine proliferative and apoptotic activity in relation with BRCA1 expression in ovarian epithelial inclusions (OEIs), the putative precursor lesions of ovarian epithelial cancer (OEC). METHODS: Benign ovaries from 95 patients were examined. Dual immunohistochemical staining for both BRCA1 and MIB-1 were performed to examine the relationship between BRCA1 and MIB-1 in OEI cells. Apoptotic activity was assessed on the parallel tissue sections by using TUNEL assay...
March 7, 2017: Journal of Ovarian Research
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