keyword
https://read.qxmd.com/read/38537223/a-systems-framework-for-investigating-the-roles-of-multiple-transporters-and-their-impact-on-drug-resistance
#1
JOURNAL ARTICLE
Manfredi di San Germano, J Krishnan
Efflux transporters are a fundamental component of both prokaryotic and eukaryotic cells, play a crucial role in maintaining cellular homeostasis, and represent a key bridge between single cell and population levels. From a biomedical perspective, they play a crucial role in drug resistance (and especially multi-drug resistance, MDR) in a range of systems spanning bacteria and human cancer cells. Typically, multiple efflux transporters are present in these cells, and the efflux transporters transport a range of substrates (with partially overlapping substrates between transporters)...
January 23, 2024: Integrative Biology: Quantitative Biosciences From Nano to Macro
https://read.qxmd.com/read/38537222/comprehension-and-usefulness-of-spanish-language-health-information-about-depression-treatment
#2
JOURNAL ARTICLE
Beatriz Manzor-Mitrzyk, Ana I Lopez-Medina, Karen B Farris
US Latine adults who prefer the Spanish language for healthcare encounter communication have high risk of health disparitiesm in part from low organizational health literacy, mental health stigma and discrimination. Latine organizational health literacy includes the provision of culturally responsive, language concordant health information, which supports good comprehension and could mitigate some health disparities. We conducted a pilot study to assess commonly provided patient health information handouts about depression treatment and antidepressant consumer medication information sheets...
March 27, 2024: Health Education Research
https://read.qxmd.com/read/38537199/fopgdb-a-pangenome-database-of-fusarium-oxysporum-a-cross-kingdom-fungal-pathogen
#3
JOURNAL ARTICLE
Tan Meng, Hanqing Jiao, Yi Zhang, Yi Zhou, Shaoying Chen, Xinrui Wang, Bowen Yang, Jie Sun, Xin Geng, Dilay Hazal Ayhan, Li Guo
Pangenomes, capturing the genetic diversity of a species or genus, are essential to understanding the ecology, pathobiology and evolutionary mechanisms of fungi that cause infection in crops and humans. However, fungal pangenome databases remain unavailable. Here, we report the first fungal pangenome database, specifically for Fusarium oxysporum species complex (FOSC), a group of cross-kingdom pathogens causing devastating vascular wilt to over 100 plant species and life-threatening fusariosis to immunocompromised humans...
March 27, 2024: Database: the Journal of Biological Databases and Curation
https://read.qxmd.com/read/38537176/toward-development-of-a-novel-proprioceptive-trail-making-test-comparing-healthy-dancers-and-non-dancers
#4
JOURNAL ARTICLE
Madison R Card, Anthony J Ryals
There is a pressing need for ecologically valid versions of traditional neuropsychological tests indexing executive function (EF), such as the Trail-Making Task (TMT), that incorporate movement and bodily awareness in healthy participants with varying abilities. We designed a proprioceptive version of the TMT (pTMT) that involved coordinated gross motor movement and proprioceptive awareness to investigate whether this measure of visual attention, task switching, and working memory positively correlated with a computerized version of the TMT (the dTMT)...
March 27, 2024: Perceptual and Motor Skills
https://read.qxmd.com/read/38537156/female-specific-health-care-of-military-female-designated-service-members-and-veterans-a-systematic-overview-of-reviews
#5
JOURNAL ARTICLE
Megan C McDermott, Megan G Musilli, Jill E Brown, John L Melton, Michael J Miller, Rhonda J Allard, Monica A Lutgendorf
INTRODUCTION: Since the War in Afghanistan began in 2001, service members have faced significant health effects related to service during war, with female-designated service members facing unique challenges. Numerous high-quality review articles have been published on the health and care of female-designated service members and veterans. Given the increasing volume of literature, we completed an overview of reviews on the health and health care of female-designated military populations...
March 27, 2024: Military Medicine
https://read.qxmd.com/read/38537138/it-s-a-trap-an-approachable-guide-to-constructing-and-using-rotating-arm-air-samplers
#6
JOURNAL ARTICLE
Jill C Check, Rebecca Harkness, Lexi Heger, Martin I Chilvers, Walter F Mahaffee, Monique L Sakalidis, Timothy D Miles
An increasing number of researchers are looking to understand the factors affecting microbial dispersion but are often limited by the costs of commercially available air samplers. Some have reduced these costs by designing self-made versions, however there are no published sampler designs and there is limited information provided on the actual construction process. Lack of appropriate reference material limits the use of these self-made samplers by many researchers. This manuscript provides a guide to designing and constructing rotating-arm impaction air samplers by covering 1) environmental considerations; 2) construction materials and equipment; 3) the construction process; and 4) air sampler deployment...
March 27, 2024: Plant Disease
https://read.qxmd.com/read/38537109/psychosocial-distress-among-young-men-who-have-sex-with-men-a-scoping-review
#7
JOURNAL ARTICLE
Isaac K Payton, Angela R Starkweather, Shantrel S Canidate, Drew A Westmoreland, Debra E Lyon
PURPOSE: Psychosocial distress negatively impacts coping and adaptation among young men (aged 18 to 44 years) who have sex with men (YMSM) with, or at risk of acquiring, HIV. However, the stressors and risky behaviors associated with psychosocial distress that impair viral suppression have not been clearly explicated. The current scoping review was conducted to explore the extant literature and identify research gaps. METHOD: PubMed and CINAHL were searched for peer-reviewed publications, with a total of eight articles meeting inclusion criteria...
April 1, 2024: Journal of Psychosocial Nursing and Mental Health Services
https://read.qxmd.com/read/38537068/fear-of-recurrence-among-lung-cancer-survivors-a-theoretical-model-validation
#8
JOURNAL ARTICLE
Qiuhong Chen, Yunqin Weng, Fangfang Wang, Xiaoyan Yang, Wei-Ti Chen, Feifei Huang
BACKGROUND: Fear of cancer recurrence (FCR) significantly impacts the treatment and prognosis of lung cancer survivors. However, the mechanisms and factors contributing to FCR and its related consequences in lung cancer remain poorly understood. OBJECTIVE: To evaluate the validity of the Lee-Jones Theoretical Model of FCR in lung cancer survivors. METHODS: A cross-sectional survey was conducted among 257 lung cancer survivors who had undergone surgical treatment 1 year prior...
March 27, 2024: Cancer Nursing
https://read.qxmd.com/read/38536997/portuguese-advance-directives-a-twist-against-futility-a-cross-sectional-study
#9
JOURNAL ARTICLE
Catarina Sampaio Martins, Rui Nunes
BACKGROUND: Advance Directive documents allow citizens to choose the treatments they want for end-of-life care without considering therapeutic futility. OBJECTIVES: To analyze patients' and caregivers' answers to Advance Directives and understand their expectations regarding their decisions. DESIGN AND SETTING: This study analyzed participants' answers to a previously published trial, conceived to test the document's efficacy as a communication tool...
2024: São Paulo Medical Journal
https://read.qxmd.com/read/38536993/factors-associated-with-voice-related-quality-of-life-among-patients-with-temporomandibular-disorders
#10
JOURNAL ARTICLE
Rüdiger Emshoff, Magdalena Astl, Aris Ioannis Giotakis, Linus Christian Hupp, Andreas Kolk
BACKGROUND: Research would be important for obtaining a better understanding of voice complaints among patients with temporomandibular disorders (TMD). OBJECTIVE: The identification of predictors of voice disorders associated with TMD pain was made according to Diagnostic Criteria for TMD (DC/TMD) Axis I. METHODOLOGY: Functional limitations were measured using the Jaw Functional Limitation Scales for mastication (JFLS-M), jaw mobility (JFLS-JM), and verbal and emotional expression (JFLS-VEE)...
2024: Journal of Applied Oral Science: Revista FOB
https://read.qxmd.com/read/38536991/-perception-of-the-food-environment-by-brazilian-slum-residents-a-qualitative-study
#11
JOURNAL ARTICLE
Luana Lara Rocha, Amélia Augusta de Lima Friche, Mariana Zogbi Jardim, Paulo César Pereira de Castro Junior, Emanuelly Porto Oliveira, Letícia de Oliveira Cardoso, Larissa Loures Mendes
Food availability in the territory can influence food consumption by the population. However, it is important to understand how people perceive their food environment to see how food availability affects consumption in different contexts. This study aimed to assess the perception of the food environment by Brazilian slum residents in their neighborhoods. This is a qualitative study, with online focus groups guided by a script in order to gather collective discourses about access to food in Brazilian slums. The invitation to participate in this study was made through social media, and community leaders and nongovernmental organizations with actions in slums were contacted using the snowball sampling technique...
2024: Cadernos de Saúde Pública
https://read.qxmd.com/read/38536984/one-step-forward-in-understanding-sleep-in-hypersensitivity-pneumonitis-patients
#12
EDITORIAL
Paulo Mateus Madureira Soares Mariano, Pedro Rodrigues Genta
No abstract text is available yet for this article.
March 22, 2024: Jornal Brasileiro de Pneumologia: Publicaça̋o Oficial da Sociedade Brasileira de Pneumologia e Tisilogia
https://read.qxmd.com/read/38536924/different-components-of-cognitive-behavioral-therapy-affect-specific-cognitive-mechanisms
#13
JOURNAL ARTICLE
Agnes Norbury, Tobias U Hauser, Stephen M Fleming, Raymond J Dolan, Quentin J M Huys
Psychological therapies are among the most effective treatments for common mental health problems-however, we still know relatively little about how exactly they improve symptoms. Here, we demonstrate the power of combining theory with computational methods to parse effects of different components of cognitive-behavioral therapies onto underlying mechanisms. Specifically, we present data from a series of randomized-controlled experiments testing the effects of brief components of behavioral and cognitive therapies on different cognitive processes, using well-validated behavioral measures and associated computational models...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536909/atom-by-atom-imaging-of-moir%C3%A3-transformations-in-2d-transition-metal-dichalcogenides
#14
JOURNAL ARTICLE
Yichao Zhang, Ji-Hwan Baek, Chia-Hao Lee, Yeonjoon Jung, Seong Chul Hong, Gillian Nolan, Kenji Watanabe, Takashi Taniguchi, Gwan-Hyoung Lee, Pinshane Y Huang
Understanding the atomic-scale mechanisms that govern the structure of interfaces is critical across materials systems but particularly so for two-dimensional (2D) moiré materials. Here, we image, atom-by-atom, the thermally induced structural evolution of twisted bilayer transition metal dichalcogenides using in situ transmission electron microscopy. We observe low-temperature, local conversion of moiré superlattice into nanoscale aligned domains. Unexpectedly, this process occurs by nucleating a new grain within one monolayer, whose crystal orientation is templated by the other...
March 29, 2024: Science Advances
https://read.qxmd.com/read/38536893/urinary-proteomics-reveals-biological-processes-related-to-acute-kidney-injury-in-bothrops-atrox-envenomings
#15
JOURNAL ARTICLE
Lisele Maria Brasileiro-Martins, Sofia Angiole Cavalcante, Thaís Pinto Nascimento, Alexandre Vilhena Silva-Neto, Marlon Dias Mariano Santos, Amanda C Camillo-Andrade, Juliana de Saldanha da Gama Fischer, Caroline Coelho Ferreira, Lucas Barbosa Oliveira, Marco Aurelio Sartim, Allyson Guimarães Costa, Manuela B Pucca, Fan Hui Wen, Ana Maria Moura-da-Silva, Jacqueline Sachett, Paulo Costa Carvalho, Priscila Ferreira de Aquino, Wuelton M Monteiro
Acute kidney injury (AKI) is a critical systemic complication caused by Bothrops envenoming, a neglected health problem in the Brazilian Amazon. Understanding the underlying mechanisms leading to AKI is crucial for effectively mitigating the burden of this complication. This study aimed to characterize the urinary protein profile of Bothrops atrox snakebite victims who developed AKI. We analyzed three groups of samples collected on admission: healthy subjects (controls, n = 10), snakebite victims who developed AKI (AKI, n = 10), and those who did not evolve to AKI (No-AKI, n = 10)...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536881/small-intestine-bacterial-overgrowth-is-associated-with-increased-campylobacter-and-epithelial-injury-in-duodenal-biopsies-of-bangladeshi-children
#16
JOURNAL ARTICLE
Shah Mohammad Fahim, Jeffrey R Donowitz, Ekaterina Smirnova, Ning-Juin Jan, Subhasish Das, Mustafa Mahfuz, S M Abdul Gaffar, William A Petri, Chelsea Marie, Tahmeed Ahmed
Small intestine bacterial overgrowth (SIBO) has been associated with enteric inflammation, linear growth stunting, and neurodevelopmental delays in children from low-income countries. Little is known about the histologic changes or epithelial adherent microbiota associated with SIBO. We sought to describe these relationships in a cohort of impoverished Bangladeshi children. Undernourished 12-18-month-old children underwent both glucose hydrogen breath testing for SIBO and duodenoscopy with biopsy. Biopsy samples were subject to both histological scoring and 16s rRNA sequencing...
March 27, 2024: PLoS Neglected Tropical Diseases
https://read.qxmd.com/read/38536879/comprehensive-mutagenesis-maps-the-effect-of-all-single-codon-mutations-in-the-aav2-rep-gene-on-aav-production
#17
JOURNAL ARTICLE
Nina K Jain, Pierce J Ogden, George M Church
Recombinant adeno-associated viruses (rAAVs) are the predominant gene therapy vector. Several rAAV vectored therapies have achieved regulatory approval, but production of sufficient rAAV quantities remains difficult. The AAV Rep proteins, which are essential for genome replication and packaging, represent a promising engineering target for improvement of rAAV production but remain underexplored. To gain a comprehensive understanding of the Rep proteins and their mutational landscape, we assayed the effects of all 39,297 possible single-codon mutations to the AAV2 rep gene on AAV2 production...
March 27, 2024: ELife
https://read.qxmd.com/read/38536875/investigating-hill-sheep-farmers-and-crofters-experiences-of-blackloss-in-the-highlands-and-islands-of-scotland
#18
JOURNAL ARTICLE
Fiona McAuliffe, Ann McLaren, Neil Sargison, Franz Brülisauer, Andrew Kent, Davy McCracken
Hill sheep farming is an important component of Scottish agriculture and comprises a significant land use in much of the Highlands and Islands. However it faces significant challenges due to the natural constraints of the landscape. Hill sheep farming uses hardy traditional breeds, such as the Scottish blackface and North Country Cheviot to graze extensive areas, where the sheep are not housed and tend to lamb on the open hill. Flocks are gathered several times a year for stock checks, husbandry, and health treatments...
2024: PloS One
https://read.qxmd.com/read/38536864/sex-related-differences-in-pre-dialysis-trajectories-and-dialysis-initiation-a-french-nationwide-retrospective-study
#19
JOURNAL ARTICLE
Maxime Raffray, Louise Bourasseau, Cécile Vigneau, Cécile Couchoud, Clémence Béchade, François Glowacki, Sahar Bayat
BACKGROUND: In the last two decades, sex and gender differences have been documented in chronic kidney disease (CKD) management, including access to renal replacement therapy and its outcomes. The objectives of this study were to 1) compare the pre-dialysis healthcare utilization in men and women, and 2) examine the sex-specific factors associated with emergency dialysis start. METHODS: Adult patients with CKD who started dialysis in France in 2015 were extracted from the Renal Epidemiology and Information Network registry...
2024: PloS One
https://read.qxmd.com/read/38536863/reinfection-of-farm-dogs-following-praziquantel-treatment-in-an-endemic-region-of-cystic-echinococcosis-in-southeastern-iran
#20
JOURNAL ARTICLE
Mehdi Borhani, Mohammad Ali Mohammadi, Mahbod Entezami, Mohammad Reza Baneshi, Saeid Nasibi, Joaquin M Prada, Majid Fasihi Harandi
Cystic Echinococcosis (CE) as a prevalent tapeworm infection of human and herbivorous animals worldwide, is caused by accidental ingestion of Echinococcus granulosus eggs excreted from infected dogs. CE is endemic in the Middle East and North Africa, and is considered as an important parasitic zoonosis in Iran. It is transmitted between dogs as the primary definitive host and different livestock species as the intermediate hosts. One of the most important measures for CE control is dog deworming with praziquantel...
March 27, 2024: PLoS Neglected Tropical Diseases
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