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https://www.readbyqxmd.com/read/29919989/discrepancy-between-readiness-to-change-insight-and-motivation-in-alcohol-dependent-inpatients
#1
(no author information available yet)
BACKGROUND: Poland, Czech Republic, and the Slovak Republic are countries with high alcohol consumption, and alcohol-induced disorders are in the ten leading causes of Years Lost due to Disability. Therefore it is necessary to study factors as insight, motivation, and readiness to change for the better understanding the variables which are in probably connected with therapeutic effectiveness. AIM: The purpose of the study was to examine the state of readiness to change at the beginning and the end of inpatient short (six weeks) and long (12 weeks) therapeutic program in the Slovak Republic, Poland, and the Czech Republic, and look for the relationship between readiness to change, insight, and motivation in alcohol-dependent persons...
May 19, 2018: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/29917335/assessment-and-management-of-older-people-with-venous-leg-ulcers
#2
Marie Todd
A venous leg ulcer (VLU) is defined as the loss of skin below the knee on the leg or foot in the presence of venous disease, which takes more than two weeks to heal. The prevalence of VLUs is increasing, especially in older people, which will increase the demand for nursing care. Development of a lower leg ulcer should trigger immediate assessment of risk factors for chronic venous disease followed by action to identify the cause and initiate treatment, which should prevent progression to more complex and chronic problems...
June 19, 2018: Nursing Older People
https://www.readbyqxmd.com/read/29917315/deep-sea-mining-potential-environmental-legal-economic-and-societal-implications-an-interdisciplinary-research
#3
REVIEW
Andrea Koschinsky, Luise Heinrich, Klaus Boehnke, J Christopher Cohrs, Till Markus, Maor Shani, Pradeep Singh, Karen Smith Stegen, Welf Werner
Deep-sea mining refers to the retrieval of marine mineral resources such as manganese nodules, ferromanganese crusts and seafloor massive sulfide deposits, which contain a variety of metals that serve as crucial raw materials for a range of applications, from electronic devices to renewable energy technologies to construction materials. With the intent of decreasing dependence on imports, supporting the economy and potentially even overcoming the environmental problems related to conventional terrestrial mining, a number of public and private institutions have re-discovered their interest in exploring the prospects of deep-sea mining, which had been deemed economically and technically unfeasible in the early 1980 s...
June 19, 2018: Integrated Environmental Assessment and Management
https://www.readbyqxmd.com/read/29917296/-experiences-of-the-burden-of-treatment-patient-reports-of-facilitated-subcutaneous-immunoglobulin-treatment-in-adults-with-immunodeficiency
#4
Christina Petersson, Ramona Fust, Carina Hagstedt, Per Vågström, Åsa Nilsdotter-Augustinsson
AIMS AND OBJECTIVES: To evaluate patient-reported experiences of facilitated subcutaneous immunoglobulin treatment in adults with primary or secondary immunodeficiency. BACKGROUND: Decreased levels of circulating antibodies (humoral immunodeficiency) are often associated with higher infection rates which cause problems in daily living, for example symptoms of severe and recurrent bacterial infections that may cause chronic lung diseases. For some diagnoses, treatment with immunoglobulin becomes critical and life-long...
June 19, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29917274/the-future-of-polar-organometallic-chemistry-written-in-bio-based-solvents-and-water
#5
Joaquín García-Álvarez, Eva Hevia, Vito Capriati
There is a strong imperative to reduce the release of volatile organic compounds (VOCs) into the environment, and many efforts are currently being made to replace conventional hazardous VOCs in favour of safe, green and bio-renewable reaction media that are not based on crude petroleum. Recent ground-breaking studies from a few laboratories worldwide have shown that both Grignard and (functionalised) organolithium reagents, traditionally handled under strict exclusion of air and humidity and in anhydrous VOCs, can smoothly promote both nucleophilic additions to unsaturated substrates and nucleophilic substitutions in water and other bio-based solvents (glycerol, deep eutectic solvents), competitively with protonolysis, at room temperature and under air...
June 19, 2018: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29917250/molecular-landscape-of-esophageal-cancer-implications-for-early-detection-and-personalized-therapy
#6
REVIEW
Fazlur Rahman Talukdar, Massimiliano di Pietro, Maria Secrier, Markus Moehler, Katrin Goepfert, Sheila Soares Coelho Lima, Luis Felipe Ribeiro Pinto, Denver Hendricks, Mohamed Iqbal Parker, Zdenko Herceg
Esophageal cancer (EC) is one of the most lethal cancers and a public health concern worldwide, owing to late diagnosis and lack of efficient treatment. Esophageal squamous cell carcinoma (ESCC) and esophageal adenocarcinoma (EAC) are main histopathological subtypes of EC that show striking differences in geographical distribution, possibly due to differences in exposure to risk factors and lifestyles. ESCC and EAC are distinct diseases in terms of cell of origin, epidemiology, and molecular architecture of tumor cells...
June 19, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29917248/population-variability-in-animal-health-influence-on-dose-exposure-response-relationships-part-i-drug-metabolism-and-transporter-systems
#7
Marilyn N Martinez, Michael H Court, Johanna Fink-Gremmels, Katrina L Mealey
There is an increasing effort to understand the many sources of population variability that can influence drug absorption, metabolism, disposition, and clearance in veterinary species. This growing interest reflects the recognition that this diversity can influence dose-exposure-response relationships and can affect the drug residues present in the edible tissues of food-producing animals. To appreciate the pharmacokinetic diversity that may exist across a population of potential drug product recipients, both endogenous and exogenous variables need to be considered...
June 19, 2018: Journal of Veterinary Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29917247/inflammasomes-in-stroke-a-triggering-role-for-acid-sensing-ion-channels
#8
REVIEW
Kanchan Vats, Deepaneeta Sarmah, Harpreet Kaur, Madhuri Wanve, Kiran Kalia, Anupom Borah, Kunjan R Dave, Dileep R Yavagal, Pallab Bhattacharya
Stroke is devastating and a major cause of morbidity and mortality around the world. The innate immune response plays an important role in various brain injuries, including stroke, and targeting it for therapeutic interventions would likely prove beneficial. The panoply of inflammatory cells, which induce various cellular, hormonal, and biochemical alterations, mediates the rapid progression of injury in stroke. The inflammasome, a multiprotein oligomer and a key component of specific innate immune responses, contributes toward the worsening of stroke outcomes by activating inflammatory cytokines...
June 19, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29917241/a-structurally-derived-model-of-subunit-dependent-nmda-receptor-function
#9
Alasdair Gibb, Kevin K Ogden, Miranda J McDaniel, Katie M Vance, Steven A Kell, Chris Butch, Pieter Burger, Dennis C Liotta, Stephen F Traynelis
NMDA receptors (NMDARs) are tetrameric complexes comprising two glycine-binding GluN1 and two glutamate-binding GluN2 subunits. Four GluN2 subunits encoded by different genes can produce up to ten different di- and triheteromeric receptors. In addition, some neurological patients contain a de novo mutation or inherited rare variant in only one subunit. There is currently no mechanistic framework to describe tetrameric receptor function that can be extended to receptors with two different GluN1 or GluN2 subunits...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917235/classification-of-gabaergic-neuron-subtypes-from-the-globus-pallidus-using-wild-type-and-transgenic-mice
#10
Karina P Abrahao, David M Lovinger
KEY POINTS: Classifying different subtypes of neurons in deep brain structures is a challenge and is crucial to better understanding brain function. Understanding the diversity of neurons in the Globus Pallidus, a brain region positioned to influence afferent and efferent information processing within basal ganglia, could help to explain a variety of brain functions. We present a classification of neurons from the GP using electrophysiological data from wild type mice and confirmation using transgenic mice...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917232/phd2-inactivation-in-type-i-cells-drives-hif-2%C3%AE-dependent-multi-lineage-hyperplasia-and-the-formation-of-paraganglioma-like-carotid-bodies
#11
James W Fielding, Emma J Hodson, Xiaotong Cheng, David J P Ferguson, Luise Eckardt, Julie Adam, Philomena Lip, Matthew Maton-Howarth, Indrika Ratnayaka, Christopher W Pugh, Keith J Buckler, Peter J Ratcliffe, Tammie Bishop
The carotid body is a peripheral chemoreceptor that plays a central role in mammalian oxygen homeostasis. In response to sustained hypoxia, it manifests rapid cellular proliferation and an associated increase in responsiveness to hypoxia. Understanding the cellular and molecular mechanisms underlying these processes is of interest both to specialised chemoreceptive functions of that organ and potentially to the general physiology and pathophysiology of cellular hypoxia. We have combined cell lineage tracing technology and conditionally inactivated alleles in recombinant mice to examine the role of components of the HIF hydroxylase pathway in specific cell types within the carotid body...
June 19, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29917229/digest-local-adaptation-at-close-quarters
#12
Chloé Schmidt, Colin Garroway
Although the theory of how gene flow and genetic drift interact with local adaptation is well understood, few empirical studies have examined this process. Hämälä et al. (2018) present evidence that adaptive divergence between populations of Arabidopsis lyrata can persist in the face of relatively high levels of gene flow and drift. Maintaining divergence despite gene flow and drift has important implications for understanding adaptive responses of populations in response to human-driven environmental change...
June 19, 2018: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29917197/crispr-technology-new-paradigm-to-target-the-infectious-disease-pathogens
#13
M A Bakhrebah, M S Nassar, M S Alsuabeyl, W A Zaher, S A Meo
OBJECTIVE: Infectious diseases are one of the prime causes of death worldwide. An innovative sequence specific editing technology "Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)" has been tested on a broad range of microorganisms to target and destroy invading foreign DNA to human cells or tissues. This study aimed to discuss the mechanism and therapeutic usage of CRISPR/Cas9 genome editing technology in the management of various infectious disease pathogens...
June 2018: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29917156/inhibition-mechanisms-of-baicalin-and-its-phospholipid-complex-against-dhav-1-replication
#14
Yun Chen, Wenjuan Yuan, Yuhui Yang, Fangke Yao, Ke Ming, Jiaguo Liu
Duck hepatitis A virus type 1 (DHAV-1) is a serious infectious virus of ducklings. Recent study showed baicalin (BA) and baicalin phospholipid complex (BAPC) possessed anti-DHAV-1 effect. However, the antiviral mechanism is not clear. Therefore, the aim of the present work is to study influences and mechanisms of BA and BAPC on DHAV-1. The effects of BA and BAPC on DHAV-1 replication were analyzed by CCK-8 and RT-qPCR methods. And the results showed BA inhibited the replication of DHAV-1, and BAPC was more effective...
June 15, 2018: Poultry Science
https://www.readbyqxmd.com/read/29917147/the-feasibility-and-acceptability-of-mass-drug-administration-for-malaria-in-cambodia-a-mixed-methods-study
#15
Thomas J Peto, Rupam Tripura, Nou Sanann, Bipin Adhikari, James Callery, Mark Droogleever, Chhouen Heng, Phaik Yeong Cheah, Chan Davoeung, Chea Nguon, Lorenz von Seidlein, Arjen M Dondorp, Christopher Pell
Background: Mass drug administrations (MDAs) are part of the World Health Organization's Plasmodium falciparum elimination strategy for the Greater Mekong Subregion (GMS). In Cambodia, a 2015-2017 clinical trial evaluated the effectiveness of MDA. This article explores factors that influence the feasibility and acceptability of MDA, including seasonal timing, financial incentives and the delivery model. Methods: Quantitative data were collected through structured questionnaires from the heads of 163 households...
June 16, 2018: Transactions of the Royal Society of Tropical Medicine and Hygiene
https://www.readbyqxmd.com/read/29917122/a-method-to-culture-chicken-enterocytes-and-their-characterization
#16
Narayan C Rath, Rohana Liyanage, Anamika Gupta, Balamurugan Packialakshmi, Jackson O Lay
Enterocytes function as both absorptive and protective components of intestine that come in close contact with a variety of enteric factors, such as dietary, microbial, and parasites, that have potential to affect the organismal health. Understanding how enterocytes interact with this complex array of factors may help improve gut health particularly in the context of poultry production where it is also linked to food safety issues. The enterocyte in vitro culture can help screen different factors and their interactions with microbiome, and potentially be utilized in the development of interventions strategies for pathogens such as antibiotic alternatives...
June 15, 2018: Poultry Science
https://www.readbyqxmd.com/read/29917092/systematic-review-and-meta-analysis-of-controlled-intervention-studies-on-the-effectiveness-of-long-chain-omega-3-fatty-acids-in-patients-with-nonalcoholic-fatty-liver-disease
#17
Kathy Musa-Veloso, Carolina Venditti, Han Youl Lee, Maryse Darch, Seth Floyd, Spencer West, Ryan Simon
Context: Treatment options for nonalcoholic fatty liver disease (NAFLD) are needed. Objective: The aim of this review was to systematically assess the effects of omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFAs), particularly eicosapentaenoic acid and docosahexaenoic acid, on liver-related and metabolic outcomes in adult and pediatric patients with NAFLD. Data Sources: The online information service ProQuest Dialog was used to search 8 literature databases...
June 15, 2018: Nutrition Reviews
https://www.readbyqxmd.com/read/29917089/inference-of-developmental-gene-regulatory-networks-beyond-classical-model-systems-new-approaches-in-the-post-genomic-era
#18
Selene L Fernandez-Valverde, Felipe Aguilera, René Alexander Ramos-Díaz
The advent of high-throughput sequencing technologies has revolutionized the way we understand the transformation of genetic information into morphological traits. Elucidating the network of interactions between genes that govern cell differentiation through development is one of the core challenges in genome research. These networks are known as developmental gene regulatory networks (dGRNs) and consist largely of the functional linkage between developmental control genes, cis-regulatory modules and differentiation genes, which generate spatially and temporally refined patterns of gene expression...
June 18, 2018: Integrative and Comparative Biology
https://www.readbyqxmd.com/read/29917075/proteomic-analysis-reveals-co-ordinated-alterations-in-protein-synthesis-and-degradation-pathways-in-lrrk2-knockout-mice
#19
Laura Pellegrini, David N Hauser, Yan Li, Adamantios Mamais, Alexandra Beilina, Ravindran Kumaran, Andrea Wetzel, George Heaton, Iakov Rudenko, Mor Alkaslasi, Natalie Ivanina, Heather L Melrose, Mark R Cookson, Kirsten Harvey
Mutations in leucine-rich repeat kinase 2 (LRRK2) segregate with familial Parkinson's disease (PD) and genetic variation around LRRK2 contributes to risk of sporadic disease. Although knockout of LRRK2 or knock-in of pathogenic mutations into the mouse germline does not result in a PD phenotype, several defects have been reported in the kidneys of LRRK2 knockout mice. To understand LRRK2 function in vivo, we used an unbiased approach to determine which protein pathways are affected in LRRK2 knockout kidneys...
June 18, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29917074/long-read-sequencing-and-de-novo-genome-assembly-of-ammopiptanthus-nanus-a-desert-shrub
#20
Fei Gao, Xue Wang, Xuming Li, Mingyue Xu, Huayun Li, Merhaba Abla, Huigai Sun, Shanjun Wei, Jinchao Feng, Yijun Zhou
Background: Ammopiptanthus nanus is a rare broad-leaved shrub in the desert and arid regions of Central Asia. This plant species exhibits extremely high tolerance to drought and freezing and has been used in abiotic tolerance research in plants. As a relic of the Tertiary period, A. nanus is of great significance to plant biogeographic research in the ancient Mediterranean region. Here we report a draft genome assembly using the PacBio platform and gene annotation for A. nanus. Findings: A total of 64...
June 18, 2018: GigaScience
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