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https://www.readbyqxmd.com/read/28432017/dual-functional-nanoparticles-for-precise-drug-delivery-to-alzheimer-s-disease-lesions-targeting-mechanisms-pharmacodynamics-and-safety
#1
Xiaoyao Zheng, Chi Zhang, Qian Guo, Xu Wan, Xiayan Shao, Qingfeng Liu, Qizhi Zhang
Alzheimer's disease (AD) is the most common form of dementia and is characterized by the cerebral accumulation of extracellular amyloid plaques. In a previous study, this histopathological hallmark was used as a target on a dual-functional nanoparticle (TQNP) to deliver biotechnological drugs, such as the H102 peptide, a β-sheet breaker, to AD lesions precisely. This delivery system could reduce the amyloid-β (Aβ) burden in the brains of AD model mice, as well as ameliorated the memory impairment of the mice...
April 18, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28429617/esas-and-fact-b-in-eribulin-treated-metastatic-breast-cancer-patients-a-multicenter-prospective-and-observational-study
#2
Luca Moscetti, Lucia Mentuccia, Patrizia Vici, Silvia Quadrini, Isabella Sperduti, Laura Pizzuti, Maria Agnese Fabbri, Angela Vaccaro, Marcello Maugeri Saccà, Maddalena Barba, Domenico Sergi, Germano Zampa, Teresa Gamucci
AIM: Quality of life (QoL) is a critical issue for women with metastatic breast cancer (MBC). Eribulin mesylate represents a novel and active drug for pretreated MBC. Regretfully, few data exploring health-related (HR) QoL are available in unselected populations. PATIENTS & METHODS: A multicenter prospective observational study was conducted in 50 MBC patients treated with eribulin mesylate, in order to evaluate HRQoL and patients' well-being by using the Edmonton symptoms assessment scale (ESAS) and Functional Assessment of Cancer Therapy-Breast questionnaires...
April 21, 2017: Future Oncology
https://www.readbyqxmd.com/read/28426360/pharmaceutical-cognitive-enhancement-in-greek-university-students-differences-between-users-and-non-users-in-social-cognitive-variables-burnout-and-engagement
#3
Lambros Lazuras, Antonia Ypsilanti, Efthymios Lamprou, Christos Kontogiorgis
Pharmaceutical cognitive enhancement (PCE) represents the non-medical use of prescribed medication for the improvement of cognitive functioning and academic performance. Although there are some studies about PCE prevalence, it is less clear how users and non-users of PCE substances differ with respect to their positive and negative student experiences (e.g. academic burnout and engagement with studies) and in social cognitive variables that relate to decision-making and self-regulation of PCE use. The present study assessed whether students with different experiences of PCE substance use displayed differences in academic burnout, study engagement, and social cognitive variables relevant to PCE use...
June 7, 2017: Substance Use & Misuse
https://www.readbyqxmd.com/read/28415894/should-patients-be-optimistic-about-surgery-resolving-a-conflicted-literature
#4
Kate Sweeny, Sara E Andrews
Following surgery, some patients suffer distress, disappointment, regret, poor adjustment, and poor quality-of-life. Surgeons may define "success" based on objective clinical outcomes, but patients' perceptions of surgical success rely primarily on a comparison to their initial expectations. We review the literature on the relationship between patients' surgical expectations and psychosocial outcomes and attempt to resolve a conflict in the literature. Specifically, we propose that conflicting conclusions regarding the merits of optimism primarily stem from differing methodological approaches by researchers in the field...
April 17, 2017: Health Psychology Review
https://www.readbyqxmd.com/read/28403872/erratum-to-validation-of-the-german-version-of-two-scales-ris-rcs-hcp-for-measuring-regret-associated-with-providing-healthcare
#5
Silvia C Richner, Stéphane Cullati, Boris Cheval, Ralph E Schmidt, Pierre Chopard, Christoph A Meier, Delphine S Courvoisier
No abstract text is available yet for this article.
April 12, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28398456/garn2-coarse-grained-prediction-of-3d-structure-of-large-rna-molecules-by-regret-minimization
#6
Mélanie Boudard, Dominique Barth, Julie Bernauer, Alain Denise, Johanne Cohen
Motivation: Predicting the 3D structure of RNA molecules is a key feature towards predicting their functions. Methods which work at atomic or nucleotide level are not suitable for large molecules. In these cases, coarse-grained prediction methods aim to predict a shape which could be refined later by using more precise methods on smaller parts of the molecule. Results: We developed a complete method for sampling 3D RNA structure at a coarse-grained model, taking a secondary structure as input...
April 7, 2017: Bioinformatics
https://www.readbyqxmd.com/read/28397047/efficacy-and-safety-of-chemotherapy-with-or-without-targeted-therapy-in-biliary-tract-cancer-a-meta-analysis-of-7-randomized-controlled-trials
#7
Xin Zhuang, Ya-Ping Xiao, Ling-Hua Tan, Lu-Ting Wang, Qian Cao, Gui-Fang Qu, Shuang Xiao, Hua-Xin Duan
The systematic treatment based on gemcitabine plus cisplatin is recommended as the current standard chemotherapy for unresectable or metastatic biliary tract cancers. However, the exact benefits from the recognized regime are still dismal. We thus elicit this study in an attempt to analyze whether targeted therapy coupled with various chemotherapy could produce improvement of survival benefits. The clinical trials were searched electronically from databases till July 2016 published in English and Chinese. Nine hundred and sixty-four patients from 7 trials were identified in our analysis...
April 2017: Journal of Huazhong University of Science and Technology. Medical Sciences
https://www.readbyqxmd.com/read/28383508/regretting-ever-starting-to-smoke-results-from-a-2014-national-survey
#8
Pratibha Nayak, Terry F Pechacek, Paul Slovic, Michael P Eriksen
Background: The majority of smokers regret ever starting to smoke, yet the vast majority continue to smoke despite the fact that smoking kills nearly 50% of lifetime users. This study examined the relationships between regret and smoker characteristics, quit history, risk perceptions, experiential thinking, and beliefs and intentions at time of smoking initiation. Methods: Data from the 2014 Tobacco Products and Risk Perceptions Survey, a nationally representative survey of United States adults, were analyzed to provide the latest prevalence estimates of regret and potential predictors...
April 6, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28381514/burnout-psychological-morbidity-job-stress-and-job-satisfaction-in-chinese-neurologists
#9
Xinyu Zhou, Juncai Pu, Xiaoni Zhong, Dan Zhu, Dinghong Yin, Lining Yang, Yuqing Zhang, Yuying Fu, Haiyang Wang, Peng Xie
OBJECTIVE: To investigate the prevalence of and personal and professional characteristics associated with burnout, psychological morbidity, job stress, and job satisfaction in Chinese neurologists. METHODS: The China Neurologist Association conducted a national cross-sectional study from September 2014 to March 2015. A questionnaire including the Maslach Burnout Inventory, the 12-item General Health Questionnaire, the Consultants' Mental Health Questionnaire, and questions assessing personal and professional characteristics, career satisfaction, and current doctor-patient relationships was administered...
April 5, 2017: Neurology
https://www.readbyqxmd.com/read/28379737/living-with-the-choice-a-grounded-theory-of-iraqi-refugee-resettlement-to-the-u-s
#10
Lisa A Davenport
Though the United States has become a place of increasing resettlement for refugees, particularly Iraqi refugees who have been forced to flee their homeland due to violence, persecution and civil unrest, little is known about Iraqi refugee resettlement in the United States, or the way in which resettlement impacts health and adjustment. A grounded theory study was conducted to develop a substantive theory of Iraqi refugee resettlement. Participants in the qualitative study included 29 Iraqi refugees and 2 community partners who participated in face-to face interviews...
April 2017: Issues in Mental Health Nursing
https://www.readbyqxmd.com/read/28370653/protecting-young-children-against-skin-cancer-parental-beliefs-roles-and-regret
#11
Kyra Hamilton, Aaron Kirkpatrick, Amanda Rebar, Katherine White, Martin S Hagger
OBJECTIVE: To examine the role of parental beliefs, roles, and anticipated regret toward performing childhood sun-protective behaviours. METHODS: Parents (N = 230; 174 mothers, 56 fathers), recruited using a non-random convenience sample, of at least one child aged between 2 and 5 years completed an initial questionnaire assessing demographics and past behaviour as well as theory of planned behaviour global (attitude, subjective norm, and perceived behavioural control) and belief-based (behavioural, normative, and control beliefs) measures, role construction, and anticipated regret regarding their intention and behaviour to protect their child from the sun...
March 31, 2017: Psycho-oncology
https://www.readbyqxmd.com/read/28366591/quality-of-life-and-patient-satisfaction-following-male-to-female-sex-reassignment-surgery
#12
Nikolaos A Papadopulos, Jean-Daniel Lellé, Dmitry Zavlin, Peter Herschbach, Gerhard Henrich, Laszlo Kovacs, Benjamin Ehrenberger, Anna-Katharina Kluger, Hans-Guenther Machens, Juergen Schaff
BACKGROUND: Surveys on quality of life (QOL) of male-to-female (MTF) transsexuals have found low QOL scores before and increased satisfaction scores after sex-reassignment surgery (SRS). To our knowledge, many of them lack standardized questionnaires and comparisons with normative data to evaluate different vaginoplasty techniques. AIM: To analyze patient satisfaction and QOL after SRS. METHODS: Forty-seven patients participated in this study...
March 30, 2017: Journal of Sexual Medicine
https://www.readbyqxmd.com/read/28351397/correlates-of-meeting-the-combined-and-independent-aerobic-and-strength-exercise-guidelines-in-hematologic-cancer-survivors
#13
James R Vallerand, Ryan E Rhodes, Gordon J Walker, Kerry S Courneya
BACKGROUND: Most previous research on the correlates of physical activity has examined the aerobic or strength exercise guidelines separately. Such an approach does not allow an examination of the correlates of meeting the combined guidelines versus a single guideline, or one guideline versus the other. Here, we report the prevalence and correlates of meeting the combined and independent exercise guidelines in hematologic cancer survivors (HCS). METHODS: In a population-based, cross-sectional survey of 606 HCS from Alberta, Canada using a mailed questionnaire, we obtained separate assessments of aerobic and strength exercise behaviors, as well as separate assessments for motivations, regulations, and reflective processes using the multi-process action control framework (M-PAC)...
March 28, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28349583/a-general-framework-for-the-regression-analysis-of-pooled-biomarker-assessments
#14
Yan Liu, Christopher McMahan, Colin Gallagher
As a cost-efficient data collection mechanism, the process of assaying pooled biospecimens is becoming increasingly common in epidemiological research; for example, pooling has been proposed for the purpose of evaluating the diagnostic efficacy of biological markers (biomarkers). To this end, several authors have proposed techniques that allow for the analysis of continuous pooled biomarker assessments. Regretfully, most of these techniques proceed under restrictive assumptions, are unable to account for the effects of measurement error, and fail to control for confounding variables...
March 28, 2017: Statistics in Medicine
https://www.readbyqxmd.com/read/28348209/strategic-siting-and-regional-grid-interconnections-key-to-low-carbon-futures-in-african-countries
#15
Grace C Wu, Ranjit Deshmukh, Kudakwashe Ndhlukula, Tijana Radojicic, Jessica Reilly-Moman, Amol Phadke, Daniel M Kammen, Duncan S Callaway
Recent forecasts suggest that African countries must triple their current electricity generation by 2030. Our multicriteria assessment of wind and solar potential for large regions of Africa shows how economically competitive and low-environmental-impact renewable resources can significantly contribute to meeting this demand. We created the Multicriteria Analysis for Planning Renewable Energy (MapRE) framework to map and characterize solar and wind energy zones in 21 countries in the Southern African Power Pool (SAPP) and the Eastern Africa Power Pool (EAPP) and find that potential is several times greater than demand in many countries...
March 27, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28347938/varying-cognitive-targets-and-response-rates-to-enhance-the-question-behaviour-effect-an-8-arm-randomized-controlled-trial-on-influenza-vaccination-uptake
#16
Mark Conner, Tracy Sandberg, Chandani Nekitsing, Russell Hutter, Chantelle Wood, Cath Jackson, Gaston Godin, Paschal Sheeran
RATIONALE: The question-behaviour effect (QBE) refers to the finding that survey questions about a behaviour can change that behaviour. However, little research has tested how the QBE can be maximized in behavioural medicine settings. The present research tested manipulations of cognitive targets (questions about anticipated regret or beneficence) and survey return rates (presence vs. absence of a sticky note requesting completion of the questionnaire) on the magnitude of the QBE for influenza vaccination in older adults...
May 2017: Social Science & Medicine
https://www.readbyqxmd.com/read/28346603/residency-program-directors-interview-methods-and-satisfaction-with-resident-selection-across-multiple-specialties
#17
Tonya VanOrder, Wayne Robbins, Eric Zemper
CONTEXT: Competition for postdoctoral training positions is at an all-time high, and residency program directors continue to have little direction when it comes to structuring an effective interview process. OBJECTIVES: To examine whether a relationship existed between interview methods used and program director satisfaction with resident selection decisions and whether programs that used methods designed to assess candidate personal characteristics were more satisfied with their decisions...
April 1, 2017: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/28341263/living-with-burn-scars-caused-by-self-immolation-among-women-in-iraqi-kurdistan-a-qualitative-study
#18
Jila Mirlashari, Alireza Nikbakht Nasrabadi, Pakestan Mohammad Amin
Patients with burns have to live with a variety of long-term physical and psychosocial consequences. Burns lead to prolonged hospital stay, disfiguring scars, disability, and even death. Since self-immolation is common in women of Iraqi Kurdistan, the present study sought to explore the experiences of women living with scars caused by self-immolation. This paper was part of a qualitative research study. A purposive sample of 18 female self-immolation survivors from Iraqi Kurdistan was selected, and 21 individual interviews were conducted and analyzed using conventional content analysis...
March 2017: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/28340584/validation-of-the-german-version-of-two-scales-ris-rcs-hcp-for-measuring-regret-associated-with-providing-healthcare
#19
Silvia C Richner, Stéphane Cullati, Boris Cheval, Ralph E Schmidt, Pierre Chopard, Christoph A Meier, Delphine S Courvoisier
BACKGROUND: The regret intensity scale (RIS) and the regret coping scale for healthcare professionals (RCS-HCP) working in hospitals assess the experience of care-related regrets and how healthcare professional deal with these negative events. The aim of this study was to validate a German version of the RIS and the RCS-HCP. METHODS: The RIS and RCS-HCP in German were first translated into German (forward- and backward translations) and then pretested with 16 German-speaking healthcare professionals...
March 24, 2017: Health and Quality of Life Outcomes
https://www.readbyqxmd.com/read/28333337/tubal-anastomosis-after-previous-sterilization-a-systematic-review
#20
Jacoba A H van Seeters, Su Jen Chua, Ben W J Mol, Carolien A M Koks
BACKGROUND: Female sterilization is one of the most common contraceptive methods. A small number of women, however, opt for reversal of sterilization procedures after they experience regret. Procedures can be performed by laparotomy or laparoscopy, with or without robotic assistance. Another commonly utilized alternative is IVF. The choice between surgery and IVF is often influenced by reimbursement politics for that particular geographic location. OBJECTIVE AND RATIONALE: We evaluated the fertility outcomes of different surgical methods available for the reversal of female sterilization, compared these to IVF and assessed the prognostic factors for success...
February 22, 2017: Human Reproduction Update
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