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Yo Niida, Hitoshi Sato, Mamoru Ozaki, Masatsune Itoh, Kanju Ikeno, Etsuko Takase
Less than 1% of the cases with Angelman syndrome (AS) are caused by chromosomal rearrangements. This category of AS is not well defined and may manifest atypical phenotypes. Here, we report a girl with AS due to der(13)t(13;15)(q14.1;q12)mat. SNP array detected the precise deletion/duplication points and the parental origin of the 15q deletion. Multicolor FISH confirmed a balanced translocation t(13;15)(q14.1;q12) in her mother. Her facial appearance showed some features of dup(13)(pter→q14). Also, she lacked the most characteristic and unique behavioral symptoms of AS, i...
October 22, 2016: Cytogenetic and Genome Research
José A S Crippa, Ana C S Crippa, Jaime E C Hallak, Rocio Martín-Santos, Antonio W Zuardi
Animal studies and preliminary clinical trials have shown that cannabidiol (CBD)-enriched extracts may have beneficial effects for children with treatment-resistant epilepsy. However, these compounds are not yet registered as medicines by regulatory agencies. We describe the cases of two children with treatment-resistant epilepsy (Case A with left frontal dysplasia and Case B with Dravet Syndrome) with initial symptom improvement after the introduction of CBD extracts followed by seizure worsening after a short time...
2016: Frontiers in Pharmacology
César F Lima, Olivia Brancatisano, Amy Fancourt, Daniel Müllensiefen, Sophie K Scott, Jason D Warren, Lauren Stewart
Some individuals show a congenital deficit for music processing despite normal peripheral auditory processing, cognitive functioning, and music exposure. This condition, termed congenital amusia, is typically approached regarding its profile of musical and pitch difficulties. Here, we examine whether amusia also affects socio-emotional processing, probing auditory and visual domains. Thirteen adults with amusia and 11 controls completed two experiments. In Experiment 1, participants judged emotions in emotional speech prosody, nonverbal vocalizations (e...
October 11, 2016: Scientific Reports
Maria A Gartstein, Wolayte Bogale, Courtney L Meehan
Cross-cultural differences in temperament were evaluated for Ethiopian (N=109) and U.S. (N=109) samples of infants. We anticipated that the Sidama version of the Infant Behavior Questionnaire-Revised (IBQ-R; Gartstein & Rothbart, 2003) developed for use in Ethiopia would demonstrate satisfactory psychometric properties, and hypothesized significant cross-cultural differences in levels of fine-grained temperament characteristics. Interactions between culture, infant age, and sex were also considered. Internal consistency was satisfactory for 13 of the 14 IBQ-R scales (with a somewhat low estimate observed for Duration of Orienting), and an examination of the structure indicated patterns similar to those observed in the US, and elsewhere...
October 6, 2016: Infant Behavior & Development
Mandy Day-Calder
As you progress through your placements, you will witness the extremes of the human condition.
September 28, 2016: Nursing Standard
Nadine Lavan, Sophie K Scott, Carolyn McGettigan
In 2 behavioral experiments, we explored how the extraction of identity-related information from familiar and unfamiliar voices is affected by naturally occurring vocal flexibility and variability, introduced by different types of vocalizations and levels of volitional control during production. In a first experiment, participants performed a speaker discrimination task on vowels, volitional (acted) laughter, and spontaneous (authentic) laughter from 5 unfamiliar speakers. We found that performance was significantly impaired for spontaneous laughter, a vocalization produced under reduced volitional control...
September 15, 2016: Journal of Experimental Psychology. General
Karin Buiting, Charles Williams, Bernhard Horsthemke
Angelman syndrome is a rare neurogenetic disorder that is characterized by microcephaly, severe intellectual deficit, speech impairment, epilepsy, EEG abnormalities, ataxic movements, tongue protrusion, paroxysms of laughter, abnormal sleep patterns, and hyperactivity. Angelman syndrome results from loss of function of the imprinted UBE3A (ubiquitin-protein ligase E3A) gene on chromosome 15q11.2-q13. This loss of function can be caused by a mutation on the maternal allele, a 5-7 Mb deletion of the maternally inherited chromosomal region, paternal uniparental disomy of chromosome 15, or an imprinting defect...
October 2016: Nature Reviews. Neurology
Adelina Anthony, Aimee Carrillo Rowe
This interview explores how performing artist, activist, writer, director, performer Adelina Anthony stages queer women of color affects as a complex terrain to mobilize a decolonial imaginary. Anthony's characters are complex, contradictory, surly, and resilient with whom audience members connect and feel deeply. Especially for queer women of color, who rarely get to see their own experiences on film or on stage, Anthony's work provides a critical forum for discussing, imagining, naming, and envisioning the connections between our personal struggles and broader forces of imperialism, heterosexual capitalism, and settler colonialism...
September 9, 2016: Journal of Lesbian Studies
Virginia Martín, Roser Granero, Josep Maria Domènech, Lourdes Ezpeleta
BACKGROUND AND OBJECTIVES: The aim of the study is to identify factors related to comorbid oppositional defiant disorder (ODD) and anxiety disorders (AD). DESIGN: A sample of 622 children was assessed longitudinally at 3 and 5 years of age. METHODS: At baseline, there were 310 boys (49.8%), most participants were of Caucasian-white-ethnicity (89.1%) and attended to public school (64.0%), and families' socioeconomic status was 64.3% medium-high, 14...
August 30, 2016: Anxiety, Stress, and Coping
Francesca D'Errico, Isabella Poggi
Research on socially aware systems requires fine-grained knowledge of the mechanisms of persuasion in order to promote civic knowledge and aware political participation. Within humor studies, political parody is generally considered a simple pleasant weapon for political evaluation, currently explained by referring to the so called "just a joke effect" (Nabi et al., 2007). Indeed the funny side of parody can induce positive emotions, but it also includes a discrediting act that sometimes produces a "bitter laughter...
2016: Frontiers in Psychology
Nadine Lavan, Carolyn McGettigan
We present an investigation of the perception of authenticity in audiovisual laughter, in which we contrast spontaneous and volitional samples and examine the contributions of unimodal affective information to multimodal percepts. In a pilot study, we demonstrate that listeners perceive spontaneous laughs as more authentic than volitional ones, both in unimodal (audio-only, visual-only) and multimodal contexts (audiovisual). In the main experiment, we show that the discriminability of volitional and spontaneous laughter is enhanced for multimodal laughter...
August 23, 2016: Quarterly Journal of Experimental Psychology: QJEP
Rod Martin, Nicholas A Kuiper
Since the start of the 21st century, the investigation of various psychological aspects of humor and laughter has become an increasingly prominent topic of research. This growth can be attributed, in no small part, to the pioneering and creative work on humor and laughter conducted by Professor Rod Martin. Dr. Martin's research interests in humor and laughter began in the early 1980s and continued throughout his 32 year long career as a professor of clinical psychology at the University of Western Ontario. During this time, Dr...
August 2016: Europe's journal of psychology
Arthur Asa Berger
This article deals with a typology of 45 techniques of humor that I found when doing research on the mechanisms that generate humor in texts, lists the techniques and applies them to a Jewish joke. It references the work of Vladimir Propp on folktales as analogous in that both are concerned with mechanisms in text that generate meaning. It also deals with four theories about why people find texts humorous, defines the joke as a short narrative with a punch line that is meant to generate mirthful laughter and defines Jewish humor as being about Jewish people and culture as told by Jewish people...
August 2016: Europe's journal of psychology
Sven Svebak
Results from two studies of biological consequences of laughter are reported. A proposed inhibitory brain mechanism was tested in Study 1. It aims to protect against trunk compression that can cause health hazards during vigorous laughter. Compression may be maximal during moderate durations and, for protective reasons, moderate in enduring vigorous laughs. Twenty-five university students volunteered to see a candid camera film. Laughter responses (LR) and the superimposed ha-responses were operationally assessed by mercury-filled strain gauges strapped around the trunk...
August 2016: Europe's journal of psychology
Nicholas A Kuiper
No abstract text is available yet for this article.
August 2016: Europe's journal of psychology
Laughter Lisenda, Lipalo Mokete, Joseph Mkubwa, Mkhululi Lukhele
PURPOSE: Total hip and knee joint arthroplasty (TJA) rank among the most successful orthopaedic operations. Several developing countries in Africa have started to perform these procedures that are routine in developed countries. The aims of this study were to measure the incidence and assess the determinants of in-hospital mortality after elective primary TJA in our unit and compare it with published data. METHODS: This was a retrospective study of the first consecutive cohort of patients who underwent elective primary TJA in Princess Marina Hospital, Botswana between March 2009 and October 2015 (6...
August 21, 2016: International Orthopaedics
Marek Susta, Veronika Nemcova, Gustav Bizik, Karel Sonka
Reported brain abnormalities in anatomy and function in patients with narcolepsy with cataplexy led to a project based on qualitative electroencephalography examination and analysis in an attempt to find a narcolepsy with cataplexy-specific brain-derived pattern, or a sequence of brain locations involved in processing humorous stimuli. Laughter is the trigger of cataplexy in these patients, and the difference between patients and healthy controls during the laughter should therefore be notable. Twenty-six adult patients (14 male, 12 female) suffering from narcolepsy with cataplexy and 10 healthy controls (five male, five female) were examined...
August 15, 2016: Journal of Sleep Research
(no author information available yet)
Tears, sadness, love and laughter are intertwined in this moving book, detailing the journey of Sian Williams who was diagnosed with breast cancer just after her 50th birthday - resulting in a double mastectomy.
August 10, 2016: Nursing Standard
Celeste M Greene, Jennifer Craft Morgan, LaVona S Traywick, Chivon A Mingo
BACKGROUND: Despite health benefits of physical activity (PA) and risks of physical inactivity, many older adults do not accumulate sufficient levels of PA to achieve associated health benefits. Lack of PA enjoyment may be a barrier to PA participation. Combining simulated laughter and PA for strength, balance, and flexibility is a potential solution for helping older adults maintain independence in activities of daily living through enjoyable participation in PA. PURPOSE OF THE STUDY: The purpose of this study is to assess whether combining simulated laughter exercises with a moderate-intensity strength, balance, and flexibility PA program (i...
August 4, 2016: Gerontologist
Fumito Kawakami, Masaki Tomonaga, Juri Suzuki
Spontaneous smiles are facial movements that are characterized by lip corner raises that occur during irregular sleep or drowsiness without known external or internal causes. They are shown by human infants and infant chimpanzees. These smiles are considered to be the developmental origin of smiling and laughter. There are some case studies showing that spontaneous smiles occur in Japanese macaques. The goals of this study were to investigate whether newborn Japanese macaques show a considerable number of spontaneous smiles thus to examine the mechanism of them...
August 2, 2016: Primates; Journal of Primatology
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