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https://www.readbyqxmd.com/read/28813123/pharmacotherapy-for-hypertension-in-adults-aged-18-to-59-years
#1
REVIEW
Vijaya M Musini, Francois Gueyffier, Lorri Puil, Douglas M Salzwedel, James M Wright
BACKGROUND: Hypertension is an important risk factor for adverse cardiovascular events including stroke, myocardial infarction, heart failure and renal failure. The main goal of treatment is to reduce these events. Systematic reviews have shown proven benefit of antihypertensive drug therapy in reducing cardiovascular morbidity and mortality but most of the evidence is in people 60 years of age and older. We wanted to know what the effects of therapy are in people 18 to 59 years of age...
August 16, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28813068/cultural-adaptation-of-the-short-self-regulation-questionnaire-suggestions-for-the-speech-area
#2
Anna Alice Almeida, Mara Behlau
Purpose: To present the translated and linguistic and culturally adapted version of the Short self-regulation Questionnaire (SSRQ) for the Brazilian Portuguese and to check its applicability to patients with dysphonia. Methods: The SSRQ is a tool used to evaluate the ability to self-regulate behavior; it has 31 items and generates three scores: total index of individual self-regulation capacity and partial scores for goal setting and impulse control. Each item should be scored by means of a Likert-type 5-point scale; the total score ranges from 29 to 145 points...
August 14, 2017: CoDAS
https://www.readbyqxmd.com/read/28812918/tyrosine-kinase-inhibitors-for-advanced-or-metastatic-thyroid-cancer-a-meta-analysis-of-randomized-controlled-trials
#3
Jen-Wei Liu, Chiehfeng Chen, El-Wui Loh, Chun-Cheng Chu, Mu-Yi Wang, Hsin-Ju Ouyang, Ya-Ting Chang, Wei-Zhan Zhuang, Ching-Wen Chou, Der-Jr Huang, Chia-Hwa Lee, Yun Yen, Ka-Wai Tam
BACKGROUND AND AIMS: Radioiodine-refractory advanced or metastatic thyroid cancer has poor prognosis. We conducted a meta-analysis of randomized controlled trials to evaluate the effectiveness and safety of tyrosine kinase inhibitors (TKIs) for advanced or metastatic thyroid cancer treatment. METHODS: Studies published until April 2017 were selected. The pooled effect size was calculated through meta-analysis by using random effects models. Outcomes were overall survival (OS), progression-free survival (PFS), objective response rate (RR), and adverse events (AEs)...
August 16, 2017: Current Medical Research and Opinion
https://www.readbyqxmd.com/read/28812573/adjusting-diet-outcome-associations-for-random-error-comparison-of-associations-based-on-observed-and-estimated-usual-intakes
#4
E Verly-Jr, R Sichieri, V T Baltar
BACKGROUND/OBJECTIVES: To compare linear regression coefficients adjusted for random errors with true coefficients. SUBJECTS/METHODS: Three hundred and two individuals from the city of Rio de Janeiro, Brazil answered 20 non-consecutive 24-hr. Means of 20 24-hr were used as an approximation of the usual dietary intakes. It was simulated outcomes with pre-defined linear regression coefficient (β=1.0, referred as 'true coefficient') for usual coffee and soft-drink intakes as explanatory variables controlled for sex and age...
August 16, 2017: European Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28812398/specific-exercises-for-subacromial-pain
#5
Hanna C Björnsson Hallgren, Lars E Adolfsson, Kajsa Johansson, Birgitta Öberg, Anna Peterson, Theresa M Holmgren
Background and purpose - We have previously shown that specific exercises reduced the need for surgery in subacromial pain patients at 1-year follow-up. We have now investigated whether this result was maintained after 5 years and compared the outcomes of surgery and non-surgical treatment. Patients and methods - 97 patients were included in the previously reported randomized study of patients on a waiting list for surgery. These patients were randomized to specific or unspecific exercises. After 3 months of exercises the patients were asked if they still wanted surgery and this was also assessed at the present 5-year follow-up...
August 16, 2017: Acta Orthopaedica
https://www.readbyqxmd.com/read/28812392/psychometric-properties-of-the-performing-arts-module-of-the-disabilities-of-the-arm-shoulder-and-hand-questionnaire
#6
Vera Baadjou, Rob de Bie, Christine Guptill, Rob Smeets
BACKGROUND: The Disabilities of the Arm, Shoulder, and Hand questionnaire (DASH) offers an optional performing arts module. The goal was to examine the psychometric properties of this module in musicians. METHODS: This study is a secondary analysis of a randomized controlled trial on the effectiveness of a biopsychosocial intervention to prevent or reduce playing-related disability in conservatory students. Baseline data were used to examine internal consistency and discriminative validity of the performing arts module of the DASH questionnaire...
August 16, 2017: Disability and Rehabilitation
https://www.readbyqxmd.com/read/28812212/obesity-treatment-with-botulinum-toxin-a-is-not-effective-a-systematic-review-and-meta-analysis
#7
REVIEW
Fabio Bustamante, Vitor Ottoboni Brunaldi, Wanderley Marques Bernardo, Diogo Turiani H de Moura, Eduardo Turiani H de Moura, Manoel Galvão, Marco Aurélio Santo, Eduardo Guimarães H de Moura
The effectiveness of gastric injections of botulinum toxin-A (BTA) as primary treatment for obesity is not well known since results in literature are discrepant. Hence, we aimed to systematically review and meta-analyze the available data to assess the real effect of BTA therapy. We searched MEDLINE, Embase, Cochrane, SCOPUS, EBSCO, LILACS, and BVS. We considered eligible only randomized controlled trials enrolling obese patients comparing BTA versus saline injections. Our initial search identified 8811 records...
August 15, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28812209/effect-of-vitamin-d-supplementation-in-chronic-widespread-pain-a-systematic-review-and-meta-analysis
#8
Wai Chung Yong, Anawin Sanguankeo, Sikarin Upala
Chronic non-specific widespread pain (CWP) including fibromyalgia (FMS) is characterized by widespread pain, reduced pain threshold, and multiple tender points on examination, causing disability and decreased quality of life. Vitamin D has been proposed as an associated factor in CWP. This meta-analysis aimed to explore the benefit of vitamin D supplementation in the management of CWP. A comprehensive search of the CENTRAL, MEDLINE, and Embase databases was performed from inception through January 2017. The inclusion criterion was the randomized clinical trials' evaluating the effects of vitamin D treatment in adult subjects with CWP or FMS...
August 15, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28812192/safety-of-vaccination-against-brucellosis-with-the-rough-strain-in-pregnant-cattle
#9
Adriana Agostini Barbosa, Ana Cristina Silva Figueiredo, Miller Pereira Palhao, Joao Henrique Moreira Viana, Carlos Antonio Carvalho Fernandes
Brucellosis is an infectious and contagious disease that profoundly impacts public health. However, in many countries, disease prevention is restricted to the vaccination of calves, and there is no prophylactic strategy for pregnant heifers and cows. The aim of this study was to evaluate the safety of the rough strain vaccine against brucellosis in pregnant cattle. Crossbred cows (N = 96) at three gestational periods (early, mid, or late pregnancy) were randomly allocated into the vaccine treatment group or to the control group...
August 15, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28812188/comparative-efficacy-of-cold-polypectomy-techniques-for-diminutive-colorectal-polyps-a-systematic-review-and-network-meta-analysis
#10
Yoon Suk Jung, Chan Hyuk Park, Eunwoo Nam, Chang Soo Eun, Dong Il Park, Dong Soo Han
BACKGROUND: Although cold polypectomy techniques are preferred over polypectomy with electrocautery in the management of diminutive polyps, comprehensive comparisons among various cold polypectomy techniques have not yet been fully performed. METHODS: We searched for all relevant randomized controlled trials published up until October 2016 examining the efficacy of cold polypectomy techniques for diminutive polyps. Cold polypectomy techniques were classified as cold forceps polypectomy (CFP), jumbo forceps polypectomy (JFP), traditional cold snare polypectomy (CSP), and dedicated CSP, according to the type of device...
August 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28812180/effect-of-continuous-positive-airway-pressure-on-glucose-metabolism-in-adults-with-type-2-diabetes-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
REVIEW
Bingqian Zhu, Chao Ma, Jindarat Chaiard, Changgui Shi
Obstructive sleep apnea (OSA) has many serious consequences, and one of these may be the exacerbation of type 2 diabetes mellitus (T2DM). Reports on the effect of continuous positive airway pressure (CPAP) on glucose metabolism in people with T2DM and OSA are conflicting. Therefore, the purpose of this review was to examine the effect of CPAP treatment on glucose metabolism by synthesizing findings from randomized controlled trials. The PRISMA review protocol was developed and registered in PROSPERO. A systematic search of PubMed, CINAHL, Embase, Web of Science, PsycInfo, and Cochrane was conducted from inception to March 2017...
August 15, 2017: Sleep & Breathing, Schlaf & Atmung
https://www.readbyqxmd.com/read/28812175/a-prospective-non-randomized-controlled-multicenter-trial-comparing-appendectomy-and-conservative-treatment-for-patients-with-uncomplicated-acute-appendicitis-the-actuaa-study
#12
Mauro Podda, Fernando Serventi, Lorenzo Mortola, Stefano Marini, Danilo Sirigu, Michela Piga, Marcello Pisano, Massimiliano Coppola, Ferdinando Agresta, Francesco Virdis, Salomone Di Saverio, Nicola Cillara
PURPOSE: Acute appendicitis (AA) is among the most common causes of lower abdominal pain and admissions to the emergency department. Over the past 20 years, there has been a renewed interest in the conservative management of uncomplicated AA, and several studies demonstrated that an antibiotic-first strategy is a viable treatment option for uncomplicated AA. The aim of this prospective non-randomized controlled, multicenter trial is to compare antibiotic therapy and emergency appendectomy as treatment for patients with uncomplicated AA confirmed by US and/or CT or MRI scan...
August 15, 2017: International Journal of Colorectal Disease
https://www.readbyqxmd.com/read/28812164/efficacy-of-fractional-lasers-in-treating-alopecia-a-literature-review
#13
Marina Perper, Adam S Aldahan, Rachel A Fayne, Christopher P Emerson, Keyvan Nouri
Hair loss stemming from different types of alopecia, such as androgenic alopecia and alopecia areata, negatively affects over half the population and, in many circumstances, causes serious psychosocial distress. Current treatment options for alopecia, such as minoxidil, anthralin, and intralesional corticosteroids, vary efficacy and side effect profiles. It is known that low-level laser/light therapies (LLLT), or photobiomodulations, such as the US FDA-cleared HairMax Lasercomb®, He-Ne laser, and excimer laser, are relatively affordable, user-friendly, safe, and effective forms of treatment for hair loss...
August 16, 2017: Lasers in Medical Science
https://www.readbyqxmd.com/read/28812161/a-proficiency-based-virtual-reality-endoscopy-curriculum-improves-performance-on-the-fundamentals-of-endoscopic-surgery-examination
#14
Daniel A Hashimoto, Emil Petrusa, Roy Phitayakorn, Christina Valle, Brenna Casey, Denise Gee
INTRODUCTION: The fundamentals of endoscopic surgery (FES) examination is a national test of knowledge and skill in flexible gastrointestinal endoscopy. The skill portion of the examination involves five tasks that assesses the following skills: scope navigation, loop reduction, mucosal inspection, retroflexion, and targeting. This project aimed to assess the efficacy of a proficiency-based virtual reality (VR) curriculum in preparing residents for the FES skills exam. METHODS: Experienced (>100 career colonoscopies) and inexperienced endoscopists (<50 career colonoscopies) were recruited to participate...
August 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28812160/robotic-versus-open-pancreatoduodenectomy-a-propensity-score-matched-analysis-based-on-factors-predictive-of-postoperative-pancreatic-fistula
#15
Niccolò Napoli, Emanuele F Kauffmann, Francesca Menonna, Francesca Costa, Sara Iacopi, Gabriella Amorese, Serena Giorgi, Angelo Baggiani, Ugo Boggi
BACKGROUND: Improvement in morbidity of pancreatoduodenectomy (PD) largely depends on the reduction in the incidence of clinically relevant (CR) postoperative pancreatic fistula (POPF). METHODS: After internal validation of the clinical risk score (CRS) of POPF, and identification of other predictive factors for POPF, robotic (RPD), and open (OPD) PDs were stratified into risk categories and matched by propensity scores. The primary endpoint of this study was incidence of CR-POPF...
August 15, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/28811993/posterolateral-fusion-versus-interbody-fusion-for-degenerative-spondylolisthesis-systematic-review-and-meta-analysis
#16
REVIEW
Ryan C Campbell, Ralph J Mobbs, Victor M Lu, Joshua Xu, Prashanth J Rao, Kevin Phan
STUDY DESIGN: Systematic review and meta-analysis. OBJECTIVE: Current surgical management of degenerative spondylolisthesis (DS) involves decompression of the spinal canal followed by fusion with or without interbody. The additional functional and operative benefits derived from interbody inclusion has yet to be thoroughly established with a number of recent studies producing conflicting results. Thus, we aim to compare the functional and operative outcomes after fusion against interbody fusion in the treatment of DS...
August 2017: Global Spine Journal
https://www.readbyqxmd.com/read/28811965/adjuvant-immunotherapy-with-autologous-dendritic-cells-for-hepatocellular-carcinoma-randomized-phase-ii-study
#17
Jeong-Hoon Lee, Won Young Tak, Yoon Lee, Min-Kyu Heo, Jae-Sung Song, Hak-Yeop Kim, Soo Young Park, Si Hyun Bae, Joon Hyeok Lee, Jeong Heo, Ki-Hwan Kim, Yong-Soo Bae, Yoon Jun Kim
Our previous phase I/IIA study showed that autologous dendritic cells (DCs) pulsed with tumor-associated antigens are well tolerated in patients with hepatocellular carcinoma (HCC). In this randomized, multicenter, open-label, phase II trial, we investigated the efficacy and safety of this DC-based adjuvant immunotherapy with 156 patients, who treated for HCC with no evidence of residual tumor after standard treatment modalities. Patients were randomly assigned to immunotherapy (n = 77; injection of 3 × 10(7) DC cells, six times over 14 weeks) or control (n = 79; no treatment)...
2017: Oncoimmunology
https://www.readbyqxmd.com/read/28811955/the-effects-of-group-based-versus-individual-based-tai-chi-training-on-nonmotor-symptoms-in-patients-with-mild-to-moderate-parkinson-s-disease-a-randomized-controlled-pilot-trial
#18
Jing Hui Yang, Ya Qun Wang, Sai Qing Ye, You Gen Cheng, Yu Chen, Xiao Zhen Feng
OBJECTIVE: To compare the effects of group-based and individual-based Tai Chi training on nonmotor symptoms in patients with mild to moderate Parkinson's disease. DESIGN: Randomized controlled pilot study. METHODS: 36 community-dwelling patients with Parkinson's disease (PD) were randomly assigned to either group-based training group (n = 19) or individual-based group (n = 17). Both groups received same content of Tai Chi training 3 times a week for 13 weeks...
2017: Parkinson's Disease
https://www.readbyqxmd.com/read/28811856/serum-betatrophin-levels-and-clinical-features-in-patients-with-poorly-controlled-type-2-diabetes
#19
Kohzo Takebayashi, Kenji Hara, Tomoko Terasawa, Rika Naruse, Mariko Suetsugu, Takafumi Tsuchiya, Toshihiko Inukai
BACKGROUND: Betatrophin is a hormone mainly secreted by the liver that influences lipid metabolisms. The main purposes of this study were to investigate the effect of canagliflozin (a sodium glucose transporter 2 inhibitor) on circulating betatrophin levels, and to investigate the correlation of various markers associated with glucose and lipid metabolisms with betatrophin in patients with poorly controlled type 2 diabetes. METHODS: Patients were randomly divided into a control group (n = 15) and a canagliflozin-treated group (n = 15)...
September 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/28811842/the-effect-of-three-different-exercise-training-modalities-on-cognitive-and-physical-function-in-a-healthy-older-population
#20
Carla Coetsee, Elmarie Terblanche
BACKGROUND: Older adults are encouraged to participate in regular physical activity to counter the age-related declines in physical and cognitive health. Literature on the effect of different exercise training modalities (aerobic vs resistance) on these health-related outcomes is not only sparse, but results are inconsistent. In general, it is believed that exercise has a positive effect on executive cognitive function, possibly because of the physiological adaptations through increases in fitness...
2017: European Review of Aging and Physical Activity
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