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https://www.readbyqxmd.com/read/28719858/interfacial-analysis-of-sirna-complexes-with-poly-ethylenimine-pei-or-pamam-dendrimers-in-gene-delivery
#1
Patrick K C Chang, Clive A Prestidge, Kristen E Bremmell
Solution and interfacial analysis has been employed to gain insight into the complexation of siRNA using either G4 PAMAM dendrimers or 25kDa branched poly-ethylenimine (bPEI). The size, charge and shape/structure of the complexing agents were probed using atomic force microscopy (AFM), circular dichroism spectrometry (CD), dynamic light scattering (DLS), and gel electrophoresis (GE). The binding capability of these cationic polymers to the siRNA molecule, subsequently controls the surface/adsorption behaviour of the complexes to a negatively charged surface...
July 8, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28719841/risk-of-treatment-related-mortality-in-cancer-patients-treated-with-ipilimumab-a-systematic-review-and-meta-analysis
#2
Sheng Zhang, Fei Liang, Wenfeng Li, Qing Wang
BACKGROUND: Fatal adverse events (FAEs) have been reported in cancer patients receiving ipilimumab-a monoclonal antibody against cytotoxic T-lymphocyte antigen-4, but the risk of treatment-related mortality is unknown. We performed a systematic review and meta-analysis of randomised controlled trials (RCTs) of ipilimumab to determine the overall risk of FAEs associated with ipilimumab. METHODS: We systematically searched MEDLINE, EMBASE, Cochrane CENTRAL, ClinicalTrial...
July 15, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28719823/supplementation-with-dietary-linseed-oil-during-peri-puberty-stimulates-steroidogenesis-and-testis-development-in-rams
#3
REVIEW
Wanhong Li, Defu Tang, Fadi Li, Huaqin Tian, Xiangpeng Yue, Fei Li, Xiuxiu Weng, Wu Sun, Weimin Wang, Futao Mo
Omega-3 polyunsaturated fatty acids (ω-3 PUFAs), such as α-linolenic acid (ALA), eicosapentaenoic acid, and docosahexaenoic acid, are involved in male reproductive function. In this study, we investigated the effects of linseed oil (LO) as a source of ALA on the steroidogenesis and changes of testicular histology in rams. Sixteen 3-month old rams during peri-puberty were randomly assigned into two groups. Eight rams were assigned as the control group, and the other received LO (4% dry matter of total diet) as the LO treatment group...
July 10, 2017: Theriogenology
https://www.readbyqxmd.com/read/28719791/effectiveness-of-psychosocial-and-educational-prenatal-and-postnatal-care-interventions-for-married-immigrant-women-in-korea-systematic-review-and-meta-analysis
#4
Sun Kyung Kim, Seyeon Park, Sukhee Ahn
The rapid influx of married immigrant women from low-income Asian countries is a concern in South Korea, Japan, and Taiwan. In South Korea, 1 in 10 couples includes a Korean man and a migrant woman, increasing the need for prenatal and postnatal care interventions. Studies published in English or Korean after 2000 were retrieved from 8 databases and reviewed via a systematic review and meta-analysis of the effectiveness of prenatal and postnatal psychosocial and educational interventions in Korea. Of 3583 records, 10 studies (1 randomized controlled trial [RCT] and 9 non-RCTs) involving 408 married immigrant women fulfilled the inclusion criteria...
July 2017: Asia-Pacific Journal of Public Health
https://www.readbyqxmd.com/read/28719783/making-sense-of-studies-that-claim-benefits-of-frenotomy-in-the-absence-of-classic-tongue-tie
#5
Pamela Douglas
By performing an in-depth analysis of one high profile example, this article aims to help breastfeeding support professionals understand the methodological flaws that characterize recent studies claiming to show the efficacy of frenotomy for the diagnoses of posterior tongue-tie and upper lip-tie. The example study does not address definitional confusion or control for the effects of the passage of time. It does not consider the effects of caring attention, validation, and lactation consultant support. It also does not consider the extensive research over the past three decades that has established that reflux in the first 6 months of life is benign, even though increased reflux frequency may correlate with unsettled infant behavior...
August 2017: Journal of Human Lactation: Official Journal of International Lactation Consultant Association
https://www.readbyqxmd.com/read/28719764/surgical-anatomy-does-not-affect-the-progression-of-intestinal-failure-associated-liver-disease-in-neonatal-piglets
#6
Celeste M Lavallee, Pamela R Wizzard, Marihan Lansing, Donna F Vine, Patrick N Nation, Jason Y Yap, Benjamin P Willing, Paul W Wales, Justine M Turner
BACKGROUND: Intestinal failure-associated liver disease (IFALD) causes significant morbidity in neonates with short bowel syndrome (SBS) dependent on parenteral nutrition (PN). Resected ileum, with loss of the ileocecal valve (ICV), is the most common anatomy in SBS, yet its impact on IFALD has not been adequately studied. METHODS: Neonatal piglets were randomized to 75% intestinal resection with jejunocolic anastomosis (JC, n = 12), 75% resection with jejunoileal anastomosis and intact ICV (JI, n = 13), PN-fed sham (sham, n = 14), or sow-fed control (SF, n = 8)...
July 1, 2017: JPEN. Journal of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/28719709/prospective-randomized-controlled-trial-using-best-selling-smoking-cessation-book
#7
James P Foshee, Anita Oh, Adam Luginbuhl, Joseph Curry, William Keane, David Cognetti
Our prospective, randomized, controlled trial aimed to evaluate the efficacy of the self-help book, The Easy Way to Stop Smoking, by Allen Carr, in promoting smoking cessation in patients with head and neck cancer. We assessed active smokers for their willingness to read a smoking cessation book. Participants were randomized to either receive the book from our department or recommended to purchase the book. All patients received smoking cessation counseling at recruitment. Phone surveys were conducted at short- and long-term intervals to determine if the patients had purchased and/or read the book and whether they were still smoking...
July 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28719708/plasmablade-vs-cold-dissection-tonsillectomy-a-prospective-randomized-double-blind-controlled-study-in-adults
#8
Rasim Yilmazer, Zahide Mine Yazici, Meliksah Balta, Ibrahim Erdim, Omer Erdur, Fatma Tulin Kayhan
We conducted a prospective, randomized, double-blind, controlled clinical study to compare the efficacy and safety of the PlasmaBlade device and cold dissection for adult tonsillectomy. Our study group was made up of 20 patients-12 men and 8 women, aged 18 to 50 years (mean: 27.1)-who were undergoing a bilateral tonsillectomy. Each patient had one randomly chosen tonsil removed by the PlasmaBlade and the other by cold instrumentation. We compared the duration of surgery, the amount of intraoperative blood loss, the number of sutures required, the status of tonsillar fossa wound healing at 7 and 14 days postoperatively, the amount of postoperative pain, and postoperative complications...
July 2017: Ear, Nose, & Throat Journal
https://www.readbyqxmd.com/read/28719669/a-whey-protein-based-multi-ingredient-nutritional-supplement-stimulates-gains-in-lean-body-mass-and-strength-in-healthy-older-men-a-randomized-controlled-trial
#9
Kirsten E Bell, Tim Snijders, Michael Zulyniak, Dinesh Kumbhare, Gianni Parise, Adrian Chabowski, Stuart M Phillips
Protein and other compounds can exert anabolic effects on skeletal muscle, particularly in conjunction with exercise. The objective of this study was to evaluate the efficacy of twice daily consumption of a protein-based, multi-ingredient nutritional supplement to increase strength and lean mass independent of, and in combination with, exercise in healthy older men. Forty-nine healthy older men (age: 73 ± 1 years [mean ± SEM]; BMI: 28.5 ± 1.5 kg/m2) were randomly allocated to 20 weeks of twice daily consumption of either a nutritional supplement (SUPP; n = 25; 30 g whey protein, 2...
2017: PloS One
https://www.readbyqxmd.com/read/28719661/minimizing-endpoint-variability-through-reinforcement-learning-during-reaching-movements-involving-shoulder-elbow-and-wrist
#10
David Marc Anton Mehler, Alexandra Reichenbach, Julius Klein, Jörn Diedrichsen
Reaching movements are comprised of the coordinated action across multiple joints. The human skeleton is redundant for this task because different joint configurations can lead to the same endpoint in space. How do people learn to use combinations of joints that maximize success in goal-directed motor tasks? To answer this question, we used a 3-degree-of-freedom manipulandum to measure shoulder, elbow and wrist joint movements during reaching in a plane. We tested whether a shift in the relative contribution of the wrist and elbow joints to a reaching movement could be learned by an implicit reinforcement regime...
2017: PloS One
https://www.readbyqxmd.com/read/28719639/oral-administration-of-chinese-herbal-medicine-during-gestation-period-for-preventing-hemolytic-disease-of-the-newborn-due-to-abo-incompatibility-a-systematic-review-of-randomized-controlled-trials
#11
Huijuan Cao, Ruohan Wu, Mei Han, Patrina Ha Yuen Caldwell, Jian-Ping Liu
BACKGROUND: About 85.3% of hemolytic disease of the newborn (HDN) is caused by maternal-fetal ABO blood group incompatibility. However, there is currently no recommended "best" therapy for ABO incompatibility during pregnancy. OBJECTIVES: To systematically assess the safety and effectiveness of oral Chinese herbal medicine (CHM) for preventing HDN due to ABO incompatibility. METHODS: The protocol of this review was registered on the PROSPERO website (No...
2017: PloS One
https://www.readbyqxmd.com/read/28719609/renal-function-following-xenon-anesthesia-for-partial-nephrectomy-an-explorative-analysis-of-a-randomized-controlled-study
#12
Ana Stevanovic, Patrick Schaefer, Mark Coburn, Rolf Rossaint, Christian Stoppe, Peter Boor, David Pfister, Axel Heidenreich, Hildegard Christ, Martin Hellmich, Astrid V Fahlenkamp
BACKGROUND: Perioperative preservation of renal function has a significant impact on morbidity and mortality in kidney surgery. Nephroprotective effects of the anesthetic xenon on ischemia-reperfusion injury were found in several experimental studies. OBJECTIVE: We aimed to explore whether xenon anesthesia can reduce renal damage in humans undergoing partial nephrectomy and to gather pilot data of possible nephroprotection in these patients. DESIGN: A prospective randomized, single-blinded, controlled study...
2017: PloS One
https://www.readbyqxmd.com/read/28719592/ten-day-quadruple-therapy-comprising-proton-pump-inhibitor-bismuth-tetracycline-and-levofloxacin-is-more-effective-than-standard-levofloxacin-triple-therapy-in-the-second-line-treatment-of-helicobacter-pylori-infection-a-randomized-controlled-trial
#13
Ping-I Hsu, Feng-Woei Tsai, Sung-Shuo Kao, Wen-Hung Hsu, Jin-Shiung Cheng, Nan-Jing Peng, Kuo-Wang Tsai, Huang-Ming Hu, Yao-Kuang Wang, Seng-Kee Chuah, Angela Chen, Deng-Chyang Wu
OBJECTIVES: Proton pump inhibitor (PPI)-amoxicillin-fluoroquinolone triple therapy is recommended as a second-line treatment of Helicobacter pylori infection in the Maastricht V/Florence Consensus Report. However, the eradication rate of this standard salvage treatment is suboptimal. The objective of this study is to compare the efficacy of esomeprazole-bismuth-tetracycline-levofloxacin therapy (TL quadruple therapy) and esomeprazole-amoxicillin-levofloxacin triple therapy (AL triple therapy) in rescue treatment for H...
July 18, 2017: American Journal of Gastroenterology
https://www.readbyqxmd.com/read/28719572/neuroimaging-correlates-of-post-stroke-aphasia-rehabilitation-in-a-pilot-randomized-trial-of-constraint-induced-aphasia-therapy
#14
Rodolphe Nenert, Jane B Allendorfer, Amber M Martin, Christi Banks, Angel Ball, Jennifer Vannest, Aimee R Dietz, Jerzy P Szaflarski
BACKGROUND Recovery from post-stroke aphasia is a long and complex process with an uncertain outcome. Various interventions have been proposed to augment the recovery, including constraint-induced aphasia therapy (CIAT). CIAT has been applied to patients suffering from post-stroke aphasia in several unblinded studies to show mild-to-moderate linguistic gains. The aim of the present study was to evaluate the neuroimaging correlates of CIAT in patients with chronic aphasia related to left middle cerebral artery stroke...
July 18, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28719566/midshaft-clavicle-fractures-the-saga-continues-commentary-on-articles-by-marcel-jun-sugawara-tamaoki-md-phd-et-al-treatment-of-displaced-midshaft-clavicle-fractures-figure-of-eight-harness-versus-anterior-plate-osteosynthesis-a-randomized-controlled-trial-and
#15
https://www.readbyqxmd.com/read/28719555/the-influence-of-shortening-on-clinical-outcome-in-healed-displaced-midshaft-clavicular-fractures-after-nonoperative-treatment
#16
E B Goudie, N D Clement, I R Murray, C R Lawrence, M Wilson, A J Brooksbank, C M Robinson
BACKGROUND: We aimed to evaluate the effect of clavicular shortening, measured with 3-dimensional computed tomography (3DCT), on functional outcomes and satisfaction in patients with healed displaced midshaft clavicular fractures up to 1 year following injury. METHODS: The data used in this study were collected as part of a multicenter, prospective randomized controlled trial of open reduction and plate fixation compared with nonoperative treatment for acute, displaced midshaft clavicular factures...
July 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28719554/treatment-of-displaced-midshaft-clavicle-fractures-figure-of-eight-harness-versus-anterior-plate-osteosynthesis-a-randomized-controlled-trial
#17
Marcel Jun Sugawara Tamaoki, Fabio Teruo Matsunaga, Adelmo Rezende Ferreira da Costa, Nicola Archetti Netto, Marcelo Hide Matsumoto, Joao Carlos Belloti
BACKGROUND: Most midshaft clavicle fractures affect the economically active population, which is negatively impacted by transient limb impairment during the treatment. There is still debate about the advantages and disadvantages of surgical treatment for these fractures. METHODS: In this prospective randomized controlled trial, 117 patients were allocated to 1 of 2 groups: nonsurgical treatment with a figure-of-eight harness or surgical treatment with anteroinferior plate osteosynthesis...
July 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28719553/the-effect-of-a-lay-led-group-based-self-management-program-for-patients-with-chronic-pain-a-randomized-controlled-trial-of-the-danish-version-of-the-chronic-pain-self-management-programme
#18
Mimi Mehlsen, Lea Hegaard, Eva Ørnbøl, Jens Søndergaard Jensen, Per Fink, Lisbeth Frostholm
The Stanford Chronic Pain Self-Management Programme (CPSMP) consists of six 2½-hour weekly workshops focusing on how to manage pain in daily life. The workshops are facilitated by two workshop leaders of whom at least one must suffer from a long-term pain condition. The program is highly structured and manualized. Only few controlled trials testing the effect of CPSMP exist.Enrolled in the study were 424 adults from 19 Danish municipalities, (72% women; age: 25-93 years) with pain of any etiology and great variation in pain history (0-50 yrs)...
June 22, 2017: Pain
https://www.readbyqxmd.com/read/28719551/annulus-fibrosus-repair-using-high-density-collagen-gel-an-in-vivo-ovine-model
#19
Brenton Pennicooke, Ibrahim Hussain, Connor Berlin, Stephen R Sloan, Brandon Borde, Yu Moriguchi, Gernot Lang, Rodrigo Navarro-Ramirez, Jonathan Cheetham, Lawrence J Bonassar, Roger Härtl
STUDY DESIGN: Ovine in vivo study. OBJECTIVE: To perform lateral approach lumbar surgery in an ovine model to administer an injectable riboflavin (RF) cross-linked high-density collagen (HDC) gel and to assess its ability to mitigate intervertebral disc (IVD) degeneration after induced annulus fibrosus (AF) injury. SUMMARY OF BACKGROUND DATA: Biological-based injectable gels have shown efficacy in restoring biomechanical, radiographic, and histological parameters in IVD-injured animal models...
July 17, 2017: Spine
https://www.readbyqxmd.com/read/28719541/systematic-review-and-meta-analysis-adalimumab-monotherapy-versus-combination-therapy-with-immunomodulators-for-induction-and-maintenance-of-remission-and-response-in-patients-with-crohn-s-disease
#20
Jean M Chalhoub, Hussein H Rimmani, Vivek V Gumaste, Ala I Sharara
BACKGROUND: It is unclear whether the combination of adalimumab (ADA) and immunomodulators is superior to ADA monotherapy in patients with Crohn's disease. METHODS: PubMed, Medline, Embase, Web of Science, and other databases were searched. Randomized controlled trials, open-label, prospective cohort, and retrospective studies, and pooled analyses were included. Primary outcomes were induction (≤12 wk) and maintenance (up to 56 wk) of remission and response. Secondary outcomes were severe adverse events, opportunistic infections, and development of antibodies to adalimumab...
August 2017: Inflammatory Bowel Diseases
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