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Andreas Kronbichler

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https://www.readbyqxmd.com/read/27899372/effect-of-rituximab-on-malignancy-risk-in-patients-with-anca-associated-vasculitis
#1
Emma E van Daalen, Raffaella Rizzo, Andreas Kronbichler, Ron Wolterbeek, Jan A Bruijn, David R Jayne, Ingeborg M Bajema, Chinar Rahmattulla
OBJECTIVES: Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) treated with cyclophosphamide have an increased malignancy risk compared with the general population. We investigated whether treatment with rituximab instead of cyclophosphamide has decreased the malignancy risk in patients with AAV. METHODS: The study included patients with AAV treated at a tertiary vasculitis referral centre between 2000 and 2014. The malignancy incidence in these patients was compared with the incidence in the general population by calculating standardised incidence ratios (SIRs), adjusted for sex, age and calendar year...
November 29, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27651302/primary-focal-segmental-glomerulosclerosis-mirnas-and-targeted-therapies
#2
REVIEW
Johannes Leierer, Gert Mayer, Andreas Kronbichler
BACKGROUND: Primary focal segmental glomerulosclerosis (FSGS) is a common cause of nephrotic syndrome. AIMS: The pathogenic steps leading to primary FSGS are still obscure, although evidence suggests that circulatory factor(s) are involved in the onset of disease. RESULTS: Recent technical advances allow the analysis of miRNA expression in tissues and body fluids, leading to reports of miRNAs involved in the molecular mechanisms of FSGS-aetiopathogenesis...
November 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27591329/moderator-s-view-the-use-of-calcineurin-inhibitors-in-the-treatment-of-lupus-nephritis
#3
Andreas Kronbichler, Irmgard Neumann, Gert Mayer
Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE), affecting ∼50% of patients, and both renal disease and treatment-related toxicity contribute to significant morbidity and mortality. Although our understanding of the aetiopathogenesis of LN is improving, treatment still remains a challenge, with the achievement of complete remission at 1 year in <50% of patients treated with current standard of care immunosuppressive therapy; this is associated with considerable short- and long-term side effects, some of which further contribute to non-adherence...
October 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27504461/soluble-urokinase-receptors-in-focal-segmental-glomerulosclerosis-a-review-on-the-scientific-point-of-view
#4
REVIEW
Andreas Kronbichler, Moin A Saleem, Björn Meijers, Jae Il Shin
Focal segmental glomerulosclerosis (FSGS) is one of the primary glomerular disorders in both children and adults which can progress to end-stage renal failure. Although there are genetic and secondary causes, circulating factors have also been regarded as an important factor in the pathogenesis of FSGS, because about 40% of the patients with FSGS have recurrence after renal transplantation. Soluble urokinase-type plasminogen activator receptor (suPAR) is a soluble form of uPAR, which is a membrane-bound protein linked to GPI in various immunologically active cells, including podocytes...
2016: Journal of Immunology Research
https://www.readbyqxmd.com/read/27429987/focal-segmental-glomerulosclerosis-genetics-mechanism-and-therapies
#5
Andreas Kronbichler, Jun Oh, Björn Meijers, Jae Il Shin
No abstract text is available yet for this article.
2016: BioMed Research International
https://www.readbyqxmd.com/read/27305294/-association-not-impossible
#6
Andreas Kronbichler
No abstract text is available yet for this article.
June 2016: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/27279884/pathogenesis-of-minimal-change-nephrotic-syndrome-an-immunological-concept
#7
REVIEW
Seong Heon Kim, Se Jin Park, Kyoung Hee Han, Andreas Kronbichler, Moin A Saleem, Jun Oh, Beom Jin Lim, Jae Il Shin
Idiopathic nephrotic syndrome (INS) in children is characterized by massive proteinuria and hypoalbuminemia. Minimal change nephrotic syndrome (MCNS) is the most common form of INS in children. The pathogenesis of MCNS still remains unclear, however, several hypotheses have been recently proposed. For several decades, MCNS has been considered a T-cell disorder, which causes the impairment of the glomerular filtration barrier with the release of different circulating factors. Increased levels of several cytokines are also suggested...
May 2016: Korean Journal of Pediatrics
https://www.readbyqxmd.com/read/27144166/treatment-strategies-of-adult-primary-focal-segmental-glomerulosclerosis-a-systematic-review-focusing-on-the-last-two-decades
#8
REVIEW
Arno Beer, Gert Mayer, Andreas Kronbichler
Adult primary focal segmental glomerulosclerosis (FSGS) remains a therapeutic challenge for the treating physician. With the advent of novel immunosuppressive measures, our arsenal of therapeutic options increased considerably. The aim of this review was to summarize reports published over the last two decades which reported on treatment outcome. Most reports included patients with a steroid-resistant (SR) disease course, yet the cohort with the highest unmet need, since persistent nephrotic range proteinuria is associated with a poor renal prognosis and portends a high risk of developing end-stage renal disease...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26989679/immunologic-changes-implicated-in-the-pathogenesis-of-focal-segmental-glomerulosclerosis
#9
REVIEW
Andreas Kronbichler, Johannes Leierer, Jun Oh, Björn Meijers, Jae Il Shin
Focal segmental glomerulosclerosis is a histological pattern on renal biopsy caused by diverse mechanisms. In its primary form, a circulatory factor is implicated in disease onset and recurrence. The natural history of primary FSGS is unpredictable, since some patients are unresponsive towards immunosuppressive measures. Immunologic changes, leading to a proinflammatory or profibrotic milieu, have been implicated in disease progression, namely, glomerular scarring, eventually leading to end-stage renal disease...
2016: BioMed Research International
https://www.readbyqxmd.com/read/26707063/renal-microrna-and-rna-profiles-in-progressive-chronic-kidney-disease
#10
Michael Rudnicki, Paul Perco, Barbara D Haene, Johannes Leierer, Andreas Heinzel, Irmgard Mühlberger, Ninella Schweibert, Judith Sunzenauer, Heinz Regele, Andreas Kronbichler, Pieter Mestdagh, Jo Vandesompele, Bernd Mayer, Gert Mayer
BACKGROUND: MicroRNAs (miRNAs) contribute to chronic kidney disease (CKD) progression via regulating mRNAs involved in renal homeostasis. However, their association with clinical outcome remains poorly understood. MATERIALS AND METHODS: We performed miRNA and mRNA expression profiling on renal biopsy sections by qPCR (miRNA) and microarrays (mRNA) in a discovery (n = 43) and in a validation (n = 29) cohort. miRNAs differentiating stable and progressive cases were inversely correlated with putative target mRNAs, which were further characterized by pathway analysis using KEGG pathways...
March 2016: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/26410887/evaluation-and-validation-of-biomarkers-in-granulomatosis-with-polyangiitis-and-microscopic-polyangiitis
#11
Andreas Kronbichler, Julia Kerschbaum, Georg Gründlinger, Johannes Leierer, Gert Mayer, Michael Rudnicki
BACKGROUND: Studies in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV) have revealed promising biomarkers. The aim of our study was to validate the most encouraging markers of granulomatosis with polyangiitis and microscopic polyangiitis identified by literature search and to create biomarker panels. METHODS: A systematic literature review was performed and we identified 161 marker molecules that were ranked by their quantitative differential expression between active and inactive disease...
June 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26318215/efficacy-of-plasma-exchange-and-immunoadsorption-in-systemic-lupus-erythematosus-and-antiphospholipid-syndrome-a-systematic-review
#12
REVIEW
Andreas Kronbichler, Biljana Brezina, Luis F Quintana, David R W Jayne
Extracorporeal treatments have been used since the 1970s in the management of systemic lupus erythematosus (SLE). A randomised controlled trial comparing the efficacy of standard of care (SOC) combined with plasma exchange against SOC alone in patients with lupus nephritis revealed no difference in terms of renal outcome. Subsequently, initial expectations have been dampened and further experience with plasma exchange is mainly limited to observational studies and single case reports. Beneficial effects have been reported in patients with refractory disease course or in pregnancy with prior complications due to SLE and antiphospholipid syndrome...
January 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/26163289/extending-the-spectrum-of-a-chameleon-igg4-related-disease-appearing-as-interstitial-nephritis-and-mimicking-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis
#13
Andreas Kronbichler, Nadezda Gut, Jochen Zwerina, Hannes Neuwirt, Michael Rudnicki, Gert Mayer
No abstract text is available yet for this article.
October 2015: Rheumatology
https://www.readbyqxmd.com/read/26117367/intrinsic-functional-connectivity-differentiates-minimally-conscious-from-unresponsive-patients
#14
MULTICENTER STUDY
Athena Demertzi, Georgios Antonopoulos, Lizette Heine, Henning U Voss, Julia Sophia Crone, Carlo de Los Angeles, Mohamed Ali Bahri, Carol Di Perri, Audrey Vanhaudenhuyse, Vanessa Charland-Verville, Martin Kronbichler, Eugen Trinka, Christophe Phillips, Francisco Gomez, Luaba Tshibanda, Andrea Soddu, Nicholas D Schiff, Susan Whitfield-Gabrieli, Steven Laureys
Despite advances in resting state functional magnetic resonance imaging investigations, clinicians remain with the challenge of how to implement this paradigm on an individualized basis. Here, we assessed the clinical relevance of resting state functional magnetic resonance imaging acquisitions in patients with disorders of consciousness by means of a systems-level approach. Three clinical centres collected data from 73 patients in minimally conscious state, vegetative state/unresponsive wakefulness syndrome and coma...
September 2015: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/26109683/opponent-s-comments
#15
Andreas Kronbichler, David R W Jayne
No abstract text is available yet for this article.
July 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/26078982/the-influence-and-role-of-microbial-factors-in-autoimmune-kidney-diseases-a-systematic-review
#16
REVIEW
Andreas Kronbichler, Julia Kerschbaum, Gert Mayer
A better understanding of the pathophysiology of autoimmune disorders is desired to allow tailored interventions. Despite increased scientific interest a direct pathogenic factor in autoimmune renal disease has been described only in a minority like membranous nephropathy or ANCA-associated vasculitis. Nonetheless the initial step leading to the formation of these antibodies is still obscure. In this review we will focus on the possible role of microbial factors in this context. Staphylococcus aureus may be a direct pathogenetic factor in granulomatosis with polyangiitis (GPA)...
2015: Journal of Immunology Research
https://www.readbyqxmd.com/read/25999374/con-should-all-patients-with-anti-neutrophil-cytoplasmic-antibody-associated-vasculitis-be-primarily-treated-with-rituximab
#17
Andreas Kronbichler, David R W Jayne
Rituximab has enriched our armamentarium in the treatment of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis. Two randomised controlled trials have shown that rituximab is non-inferior compared with cyclophosphamide followed by azathioprine for the induction of remission. The newly diagnosed patients in the Rituximab in ANCA-Associated Vasculitis (RAVE) and Rituximab Versus Cyclophosphamide in ANCA-Associated Vasculitis (RITUXVAS) trials had a numerically higher response rate in the cyclophosphamide/azathioprine arm, and the number of such patients treated with rituximab numbered <90...
July 2015: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/25627555/frequency-risk-factors-and-prophylaxis-of-infection-in-anca-associated-vasculitis
#18
REVIEW
Andreas Kronbichler, David R W Jayne, Gert Mayer
BACKGROUND: Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides are potentially life-threatening disorders. MATERIALS AND METHODS: Even though immunosuppressive therapy improves the prognosis, adverse events, either attributable to persistent disease activity or side effects of treatment remain a challenge. Infectious complications are the leading cause of death in the first year after diagnosis and a major cause of morbidity and mortality thereafter...
March 2015: European Journal of Clinical Investigation
https://www.readbyqxmd.com/read/25474424/efficacy-of-eculizumab-in-a-patient-with-immunoadsorption-dependent-catastrophic-antiphospholipid-syndrome-a-case-report
#19
Andreas Kronbichler, Renate Frank, Michael Kirschfink, Ágnes Szilágyi, Dorottya Csuka, Zoltán Prohászka, Peter Schratzberger, Karl Lhotta, Gert Mayer
Catastrophic antiphospholipid syndrome (CAPS) is a rare but devastating complication in patients with antiphospholipid syndrome (APS) with a high morbidity and mortality.We describe a case of a 30-year old female patient with immunoglobulin A (IgA) deficiency who underwent splenectomy because of idiopathic thrombocytopenic thrombocytopenia. Subsequently, an APS and finally systemic lupus erythematosus was diagnosed. After an uncomplicated pregnancy that was terminated by cesarean section, the patient developed severe CAPS with cerebral, myocardial, renal, and pulmonary involvement...
November 2014: Medicine (Baltimore)
https://www.readbyqxmd.com/read/25401966/rituximab-in-adult-minimal-change-disease-and-focal-segmental-glomerulosclerosis
#20
REVIEW
Andreas Kronbichler, Annette Bruchfeld
Treatment of nephrotic syndrome due to minimal change disease and focal segmental glomerulosclerosis remains a challenge since steroid dependence, steroid resistance and a relapsing disease course exhibits a high cumulative steroid dosage. The necessity of using alternative steroid-sparing immunosuppressive agents with potential toxic side effects also restricts their long-term use. Rituximab, a monoclonal antibody targeting CD20, has been increasingly used in the therapy of difficult-to-treat nephrotic syndrome...
2014: Nephron. Clinical Practice
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