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Andreas Kronbichler

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https://www.readbyqxmd.com/read/29670902/nephrotic-syndrome-genetics-mechanism-and-therapies
#1
EDITORIAL
Jae Il Shin, Andreas Kronbichler, Jun Oh, Björn Meijers
No abstract text is available yet for this article.
2018: BioMed Research International
https://www.readbyqxmd.com/read/29600945/l%C3%A3-fgren-syndrome-as-secondary-autoimmune-disease-in-a-patient-with-b-cell-depletion-following-rituximab-treatment
#2
Andreas Kronbichler, Anna K Luger, Lorin Loacker, Alex Pizzini, Judith Löffler-Ragg, Ines Peschel
No abstract text is available yet for this article.
March 21, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29556761/recent-advances-of-animal-model-of-focal-segmental-glomerulosclerosis
#3
REVIEW
Jae Won Yang, Anne Katrin Dettmar, Andreas Kronbichler, Heon Yung Gee, Moin Saleem, Seong Heon Kim, Jae Il Shin
In the last decade, great advances have been made in understanding the genetic basis for focal segmental glomerulosclerosis (FSGS). Animal models using specific gene disruption of the slit diaphragm and cytoskeleton of the foot process mirror the etiology of the human disease. Many animal models have been developed to understand the complex pathophysiology of FSGS. Therefore, we need to know the usefulness and exact methodology of creating animal models. Here, we review classic animal models and newly developed genetic animal models...
March 20, 2018: Clinical and Experimental Nephrology
https://www.readbyqxmd.com/read/29405620/therapeutic-plasma-exchange-strategy-in-complement-mediated-diseases-an-overview
#4
EDITORIAL
Andreas Kronbichler
No abstract text is available yet for this article.
February 2018: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29385531/comment-on-rituximab-therapy-for-takayasu-arteritis-a-seven-patients-experience-and-a-review-of-the-literature
#5
Daiki Nakagomi, Andreas Kronbichler, Torsten Witte, Aladdin J Mohammad, David R W Jayne
No abstract text is available yet for this article.
January 29, 2018: Rheumatology
https://www.readbyqxmd.com/read/29353099/cardiovascular-involvement-in-systemic-rheumatic-diseases-an-integrated-view-for-the-treating-physicians
#6
REVIEW
Kwang Seob Lee, Andreas Kronbichler, Michael Eisenhut, Keum Hwa Lee, Jae Il Shin
Systemic autoimmune diseases can affect various kinds of organs including the kidney, the skin, soft tissue and the bone. Among others, cardiovascular involvement in rheumatic diseases has been shown to affect myocardium, pericardium, cardiac vessels, conduction system and valves, eventually leading to increased mortality. In general, underlying chronic inflammation leads to premature atherosclerosis, but also other manifestations such as arrhythmia and heart failure may have a 'silent' progress. Traditional cardiovascular risk factors play a secondary role, while disease-specific factors (i...
March 2018: Autoimmunity Reviews
https://www.readbyqxmd.com/read/29205892/biological-agents-and-therapeutic-plasma-exchange-can-they-coexist-in-the-future
#7
EDITORIAL
Andreas Kronbichler
No abstract text is available yet for this article.
December 2017: Therapeutic Apheresis and Dialysis
https://www.readbyqxmd.com/read/29165061/posterior-nutcracker-syndrome-a-systematic-review
#8
REVIEW
Jae Hyon Park, Gi Hoon Lee, Seul Mi Lee, Michael Eisenhut, Andreas Kronbichler, Keum Hwa Lee, Jae Il Shin
Posterior nutcracker syndrome (PNCS) is the entrapment of the left renal vein between the aorta and the vertebral column. Although uncommon, it is still an important diagnosis due to the high morbidity associated with the risk of secondary anaemia from haematuria, from long-term left renal vein hypertension, vascular thrombosis, and even blood clots in the urinary system. A literature search of PubMed and EMBASE databases was performed and 27 publications containing 27 cases were included for the final analysis...
January 2018: VASA. Zeitschrift Für Gefässkrankheiten
https://www.readbyqxmd.com/read/29055398/dapsone-as-a-potential-treatment-option-for-henoch-sch%C3%A3-nlein-purpura-hsp
#9
Keum Hwa Lee, Jae Hyon Park, Dong Hyun Kim, Jimin Hwang, Goeun Lee, Jae Seok Hyun, Sung Taik Heo, Ji Hoon Choi, Minwoo Kim, Minhye Kim, Seong Il Kim, Michael Eisenhut, Andreas Kronbichler, Jae Il Shin
Henoch-Schönlein Purpura (HSP, IgA vasculitis) is an immunoglobulin A (IgA) mediated disorder characterized by systemic vasculitis with variable presentation, frequently affecting the skin, mucous membrane, joints, kidneys, and rarely lungs and the central nervous system. Interestingly, enhanced production of interleukin-8 (IL-8) levels are found during active disease and increased levels have been reported in supernatants from human umbilical venous endothelial cells after stimulation with sera from patients affected by HSP...
October 2017: Medical Hypotheses
https://www.readbyqxmd.com/read/29027112/field-synopsis-and-re-analysis-of-systematic-meta-analyses-of-genetic-association-studies-in-multiple-sclerosis-a-bayesian-approach
#10
Jae Hyon Park, Joo Hi Kim, Kye Eun Jo, Se Whan Na, Michael Eisenhut, Andreas Kronbichler, Keum Hwa Lee, Jae Il Shin
To provide an up-to-date summary of multiple sclerosis-susceptible gene variants and assess the noteworthiness in hopes of finding true associations, we investigated the results of 44 meta-analyses on gene variants and multiple sclerosis published through December 2016. Out of 70 statistically significant genotype associations, roughly a fifth (21%) of the comparisons showed noteworthy false-positive rate probability (FPRP) at a statistical power to detect an OR of 1.5 and at a prior probability of 10-6 assumed for a random single nucleotide polymorphism...
October 12, 2017: Molecular Neurobiology
https://www.readbyqxmd.com/read/28939140/clinical-presentation-management-and-prognostic-factors-of-idiopathic-systemic-capillary-leak-syndrome-a-systematic-review
#11
Tae Seong Eo, Kyung Ju Chun, Su Jung Hong, Ji Young Kim, I Re Lee, Keum Hwa Lee, Michael Eisenhut, Andreas Kronbichler, Jae Il Shin
BACKGROUND: The idiopathic systemic capillary leak syndrome is a rare disease characterized by unexplained recurrent shock caused by capillary hyperpermeability. Because of the rarity of the disease, this disease has easily been misdiagnosed and evidence of efficacious agents used empirically is lacking. OBJECTIVE: To analyze the clinical and laboratory data, treatment modalities, and mortality rate of patients and to find contributing factors leading to mortality...
September 19, 2017: Journal of Allergy and Clinical Immunology in Practice
https://www.readbyqxmd.com/read/28904948/recent-progress-in-deciphering-the-etiopathogenesis-of-primary-membranous-nephropathy
#12
REVIEW
Andreas Kronbichler, Jun Oh, Björn Meijers, Gert Mayer, Jae Il Shin
Primary membranous nephropathy (MN) is the leading cause of nephrotic syndrome in adults. Discovery of several antibodies has contributed to an increased understanding of MN. Antibodies against the M-type phospholipase A2 receptor (PLA2R) are present in 50-100% with primary MN and are associated with a lower frequency of spontaneous remission. High levels are linked with a higher probability of treatment resistance, higher proteinuria, and impaired renal function, as well as a more rapid decline of kidney function during follow-up...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28899799/neutrophil-extracellular-traps-nets-in-autoimmune-diseases-a-comprehensive-review
#13
REVIEW
Keum Hwa Lee, Andreas Kronbichler, David Duck-Young Park, YoungMin Park, Hanwool Moon, Hyungdo Kim, Jun Hyug Choi, YoungSeo Choi, Songjoo Shim, Il Suk Lyu, Byung Hwan Yun, Yeonseung Han, Donghee Lee, Sang Yoon Lee, Byung Hun Yoo, Kyung Hwan Lee, Tai Lim Kim, Heonki Kim, Joo Sung Shim, Wonseok Nam, Heesung So, SooYeon Choi, Sangmok Lee, Jae Il Shin
Neutrophil extracellular traps (NETs) are fibrous networks which protrude from the membranes of activated neutrophils. NETs are found in a variety of conditions such as infection, malignancy, atherosclerosis, and autoimmune diseases including rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), anti-neutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV), psoriasis, and gout. Studies suggest that an imbalance between "NETosis," which is a process by which NETs are formed, and NET degradation may be associated with autoimmune diseases...
November 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28780079/antineutrophil-cytoplasmic-antibody-associated-vasculitides-and-igg4-related-disease-a-new-overlap-syndrome
#14
REVIEW
François-Xavier Danlos, Giovanni Maria Rossi, Daniel Blockmans, Giacomo Emmi, Andreas Kronbichler, Stéphane Durupt, Claire Maynard, Luminita Luca, Cyril Garrouste, Bertrand Lioger, Rachel Mourot-Cottet, Robin Dhote, Jean-Benoit Arlet, Thomas Hanslik, Philippe Rouvier, Mikael Ebbo, Xavier Puéchal, Dominique Nochy, Agnès Carlotti, Luc Mouthon, Loïc Guillevin, Augusto Vaglio, Benjamin Terrier
OBJECTIVE: Atypical manifestations have been described in patients with ANCA-associated vasculitides (AAV), such as pachymeningitis, orbital mass or chronic periaortitis. Because these manifestations have been associated to the spectrum of IgG4-related disease (IgG4-RD), we hypothesized that both diseases could overlap. METHODS: We conducted a European retrospective multicenter observational study including patients fulfilling ACR and Chapel Hill criteria for AAV and IgG4-RD Comprehensive Diagnostic Criteria...
October 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28646289/delta-neutrophil-index-dni-as-a-novel-diagnostic-and-prognostic-marker-of-infection-a-systematic-review-and-meta-analysis
#15
Jae Hyon Park, Hyeong Ju Byeon, Keum Hwa Lee, Jong Wook Lee, Andreas Kronbichler, Michael Eisenhut, Jae Il Shin
OBJECTIVE: Delta neutrophil index (DNI) representing the number of immature granulocytes is an emerging marker used in diagnosis of infections and prediction of mortality in infected patients. The present study evaluated the diagnostic accuracy of DNI as a predictive and prognostic factor in infected patients. METHODS: We performed a PubMed search on January 1st, 2017 and identified studies that evaluated DNI as either a predictive or prognostic factor in infected patients...
October 2017: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/28414152/rituximab-for-immunologic-renal-disease-what-the-nephrologist-needs-to-know
#16
REVIEW
Andreas Kronbichler, Martin Windpessl, Herwig Pieringer, David R W Jayne
Rituximab (RTX), a chimeric, monoclonal anti-CD20 antibody, is increasingly used in immune-mediated renal diseases. While licensed in the induction treatment of ANCA-associated vasculitis, it represents one of the most commonly prescribed off-label drugs. Much of the information regarding its safety has been drawn from experience in hematology and rheumatology. Ample evidence illustrates the safety of RTX, however, rare but serious adverse events have emerged that include progressive multifocal leucoencephalopathy and hepatitis B reactivation...
June 2017: Autoimmunity Reviews
https://www.readbyqxmd.com/read/28412022/acute-kidney-injury-is-associated-with-microvascular-myocardial-damage-following-myocardial-infarction
#17
Sebastian Johannes Reinstadler, Andreas Kronbichler, Martin Reindl, Hans-Josef Feistritzer, Veronika Innerhofer, Agnes Mayr, Gert Klug, Martin Tiefenthaler, Gert Mayer, Bernhard Metzler
Acute kidney injury (AKI) is a frequent complication in patients with ST-elevation myocardial infarction (STEMI) treated by primary percutaneous coronary intervention. However, the pathophysiology of AKI in this setting is complex and goes beyond the administration of contrast media. Studies assessing the impact of infarct characteristics on AKI are currently lacking. Therefore, we investigated the association of AKI with myocardial as well as microvascular injury in an initial total of 361 consecutive STEMI patients treated by primary percutaneous coronary intervention...
September 2017: Kidney International
https://www.readbyqxmd.com/read/28169298/the-value-of-delta-neutrophil-index-in-young-infants-with-febrile-urinary-tract-infection
#18
Jung Won Lee, Seong Heon Kim, Se Jin Park, Keum Hwa Lee, Jae Hyon Park, Andreas Kronbichler, Michael Eisenhut, Ji Hong Kim, Jong Wook Lee, Jae Il Shin
Delta neutrophil index (DNI) is the fraction of circulating immature granulocytes, which reflects severe bacterial infections and septic condition but has not been studied in urinary tract infection (UTI). Here, we evaluated the value of DNI in predicting acute pyelonephritis (APN) or vesicoureteral reflux (VUR) using the data of 288 patients. Conventional inflammatory markers (white blood cell [WBC] count, erythrocyte sedimentation rate [ESR], C-reactive protein [CRP]), and DNI were measured. WBC, CRP, ESR and DNI were higher in APN than in lower UTI (p < 0...
February 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28053275/clinical-associations-with-venous-thromboembolism-in-anti-neutrophil-cytoplasm-antibody-associated-vasculitides
#19
RANDOMIZED CONTROLLED TRIAL
Andreas Kronbichler, Johannes Leierer, Gisela Leierer, Gert Mayer, Alina Casian, Peter Höglund, Kerstin Westman, David Jayne
Objective.: To assess potential associations for the development of venous thromboembolic events in patients with ANCA-associated vasculitides (AAV). Methods.: Four hundred and seventeen patients enrolled to participate in randomized controlled trials conducted by the European Vasculitis Society were identified. Univariate and multivariate analyses were performed to validate previously proposed and identify novel risks associated with venous thromboembolism (VTE) in AAV...
May 1, 2017: Rheumatology
https://www.readbyqxmd.com/read/27899372/effect-of-rituximab-on-malignancy-risk-in-patients-with-anca-associated-vasculitis
#20
Emma E van Daalen, Raffaella Rizzo, Andreas Kronbichler, Ron Wolterbeek, Jan A Bruijn, David R Jayne, Ingeborg M Bajema, Chinar Rahmattulla
OBJECTIVES: Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) treated with cyclophosphamide have an increased malignancy risk compared with the general population. We investigated whether treatment with rituximab instead of cyclophosphamide has decreased the malignancy risk in patients with AAV. METHODS: The study included patients with AAV treated at a tertiary vasculitis referral centre between 2000 and 2014. The malignancy incidence in these patients was compared with the incidence in the general population by calculating standardised incidence ratios (SIRs), adjusted for sex, age and calendar year...
June 2017: Annals of the Rheumatic Diseases
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