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David Jayne

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https://www.readbyqxmd.com/read/29776800/risk-of-emergency-hospital-admission-in-children-associated-with-mental-disorders-and-alcohol-misuse-in-the-household-an-electronic-birth-cohort-study
#1
Shantini Paranjothy, Annette Evans, Amrita Bandyopadhyay, David Fone, Behnaz Schofield, Ann John, Mark A Bellis, Ronan A Lyons, Daniel Farewell, Sara Jayne Long
BACKGROUND: Mental disorders and alcohol misuse are common in families but their effects on the physical health of children are not known. We investigated the risk of emergency hospital admissions during childhood associated with living with an adult who has a mental health disorder, or who had an alcohol-related hospital admission. METHODS: We did this cohort study in a total population electronic child cohort in Wales, UK, which includes all children who live in Wales or with a mother who is resident in Wales...
May 15, 2018: Lancet. Public Health
https://www.readbyqxmd.com/read/29755653/tumornext-lynch-mmr-a-comprehensive-next-generation-sequencing-assay-for-the-detection-of-germline-and-somatic-mutations-in-genes-associated-with-mismatch-repair-deficiency-and-lynch-syndrome
#2
Phillip N Gray, Pei Tsai, Daniel Chen, Sitao Wu, Jayne Hoo, Wenbo Mu, Bing Li, Huy Vuong, Hsiao-Mei Lu, Navanjot Batth, Sara Willett, Lisa Uyeda, Swati Shah, Chia-Ling Gau, Monalyn Umali, Carin Espenschied, Mike Janicek, Sandra Brown, David Margileth, Lavinia Dobrea, Lawrence Wagman, Huma Rana, Michael J Hall, Theodora Ross, Jonathan Terdiman, Carey Cullinane, Savita Ries, Ellen Totten, Aaron M Elliott
The current algorithm for Lynch syndrome diagnosis is highly complex with multiple steps which can result in an extended time to diagnosis while depleting precious tumor specimens. Here we describe the analytical validation of a custom probe-based NGS tumor panel, TumorNext-Lynch-MMR, which generates a comprehensive genetic profile of both germline and somatic mutations that can accelerate and streamline the time to diagnosis and preserve specimen. TumorNext-Lynch-MMR can detect single nucleotide variants, small insertions and deletions in 39 genes that are frequently mutated in Lynch syndrome and colorectal cancer...
April 17, 2018: Oncotarget
https://www.readbyqxmd.com/read/29742136/impact-on-birth-weight-and-child-growth-of-participatory-learning-and-action-women-s-groups-with-and-without-transfers-of-food-or-cash-during-pregnancy-findings-of-the-low-birth-weight-south-asia-cluster-randomised-controlled-trial-lbwsat-in-nepal
#3
Naomi M Saville, Bhim P Shrestha, Sarah Style, Helen Harris-Fry, B James Beard, Aman Sen, Sonali Jha, Anjana Rai, Vikas Paudel, Raghbendra Sah, Puskar Paudel, Andrew Copas, Bishnu Bhandari, Rishi Neupane, Joanna Morrison, Lu Gram, Anni-Maria Pulkki-Brännström, Jolene Skordis-Worrall, Machhindra Basnet, Saskia de Pee, Andrew Hall, Jayne Harthan, Meelan Thondoo, Sonja Klingberg, Janice Messick, Dharma S Manandhar, David Osrin, Anthony Costello
BACKGROUND: Undernutrition during pregnancy leads to low birthweight, poor growth and inter-generational undernutrition. We did a non-blinded cluster-randomised controlled trial in the plains districts of Dhanusha and Mahottari, Nepal to assess the impact on birthweight and weight-for-age z-scores among children aged 0-16 months of community-based participatory learning and action (PLA) women's groups, with and without food or cash transfers to pregnant women. METHODS: We randomly allocated 20 clusters per arm to four arms (average population/cluster = 6150)...
2018: PloS One
https://www.readbyqxmd.com/read/29718465/proteinase-3-and-myeloperoxidase-serotype-in-relation-to-demographic-factors-and-geographic-distribution-in-anti-neutrophil-cytoplasmic-antibody-associated-glomerulonephritis
#4
Maria Weiner, Rune Bjørneklett, Zdenka Hrušková, Bruce Mackinnon, Caroline J Poulton, Leo Sindelar, Aladdin J Mohammad, Per Eriksson, Loreto Gesualdo, Duvuru Geetha, Matija Crnogorac, David Jayne, Susan L Hogan, Colin Geddes, Vladimir Tesar, Knut Aasarød, Mårten Segelmark
Background: In anti-neutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis, antigen specificity varies between myeloperoxidase (MPO) and proteinase 3 (PR3). This has been reported to vary in relation to age, gender, geography and extrarenal manifestations. However, studies are difficult to compare as criteria for inclusion vary. The aim of this study was to investigate the relationship between ANCA serotype, latitude, ultraviolet (UV) radiation levels, age, gender and renal function at diagnosis in a large study with uniform inclusion criteria...
April 30, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29703844/a-genome-wide-association-study-of-diabetic-kidney-disease-in-subjects-with-type-2-diabetes
#5
Natalie R van Zuydam, Emma Ahlqvist, Niina Sandholm, Harshal Deshmukh, N William Rayner, Moustafa Abdalla, Claes Ladenvall, Daniel Ziemek, Eric Fauman, Neil R Robertson, Paul M McKeigue, Erkka Valo, Carol Forsblom, Valma Harjutsalo, Annalisa Perna, Erica Rurali, M Loredana Marcovecchio, Robert P Igo, Rany M Salem, Norberto Perico, Maria Lajer, Annemari Käräjämäki, Minako Imamura, Michiaki Kubo, Atsushi Takahashi, Xueling Sim, Jianjun Liu, Rob M van Dam, Guozhi Jiang, Claudia H T Tam, Andrea O Y Luk, Heung Man Lee, Cadmon K P Lim, Cheuk Chun Szeto, Wing Yee So, Juliana C N Chan, Su Fen Ang, Rajkumar Dorajoo, Ling Wang, Tan Si Hua Clara, Amy-Jayne McKnight, Seamus Duffy, Marcus G Pezzolesi, Genie Consortium, Michel Marre, Beata Gyorgy, Samy Hadjadj, Linda T Hiraki, Tarunveer S Ahluwalia, Peter Almgren, Christina-Alexandra Schulz, Marju Orho-Melander, Allan Linneberg, Cramer Christensen, Daniel R Witte, Niels Grarup, Ivan Brandslund, Olle Melander, Andrew D Paterson, David Tregouet, Alexander P Maxwell, Su Chi Lim, Ronald C W Ma, E Shyong Tai, Shiro Maeda, Valeriya Lyssenko, Tiinamaija Tuomi, Andrzej S Krolewski, Stephen S Rich, Joel N Hirschhorn, Jose C Florez, David Dunger, Oluf Pedersen, Torben Hansen, Peter Rossing, Giuseppe Remuzzi, Mary Julia Brosnan, Colin N A Palmer, Per-Henrik Groop, Helen M Colhoun, Leif C Groop, Mark I McCarthy
Identification of sequence variants robustly associated with predisposition to diabetic kidney disease (DKD) has the potential to provide insights into the pathophysiological mechanisms responsible. We conducted a genome-wide association study (GWAS) of DKD in type 2 diabetes (T2D) using eight complementary dichotomous and quantitative DKD phenotypes: the principal dichotomous analysis involved 5,717 T2D subjects, 3,345 with DKD. Promising association signals were evaluated in up to 26,827 subjects with T2D (12,710 with DKD)...
April 27, 2018: Diabetes
https://www.readbyqxmd.com/read/29699523/accuracy-of-risk-scales-for-predicting-repeat-self-harm-and-suicide-a-multicentre-population-level-cohort-study-using-routine-clinical-data
#6
Sarah Steeg, Leah Quinlivan, Rebecca Nowland, Robert Carroll, Deborah Casey, Caroline Clements, Jayne Cooper, Linda Davies, Duleeka Knipe, Jennifer Ness, Rory C O'Connor, Keith Hawton, David Gunnell, Nav Kapur
BACKGROUND: Risk scales are used widely in the management of patients presenting to hospital following self-harm. However, there is evidence that their diagnostic accuracy in predicting repeat self-harm is limited. Their predictive accuracy in population settings, and in identifying those at highest risk of suicide is not known. METHOD: We compared the predictive accuracy of the Manchester Self-Harm Rule (MSHR), ReACT Self-Harm Rule (ReACT), SAD PERSONS Scale (SPS) and Modified SAD PERSONS Scale (MSPS) in an unselected sample of patients attending hospital following self-harm...
April 25, 2018: BMC Psychiatry
https://www.readbyqxmd.com/read/29695241/novel-risk-genes-identified-in-a-genome-wide-association-study-for-coronary-artery-disease-in-patients-with-type-1-diabetes
#7
Romain Charmet, Seamus Duffy, Sareh Keshavarzi, Beata Gyorgy, Michel Marre, Peter Rossing, Amy Jayne McKnight, Alexander P Maxwell, Tarun Veer Singh Ahluwalia, Andrew D Paterson, David-Alexandre Trégouët, Samy Hadjadj
BACKGROUND: Patients with type 1 diabetes are more at risk of coronary artery disease than the general population. Although evidence points to a genetic risk there have been no study investigating genetic risk factors of coronary artery disease specific to individuals with type 1 diabetes. To identify low frequency and common genetic variations associated with coronary artery disease in populations of individuals with type 1 diabetes. METHODS: A two-stage genome wide association study was conducted...
April 25, 2018: Cardiovascular Diabetology
https://www.readbyqxmd.com/read/29690649/responses-to-the-selective-bruton-s-tyrosine-kinase-btk-inhibitor-tirabrutinib-ono-gs-4059-in-diffuse-large-b-cell-lymphoma-cell-lines
#8
Ryohei Kozaki, Meike Vogler, Harriet S Walter, Sandrine Jayne, David Dinsdale, Reiner Siebert, Martin J S Dyer, Toshio Yoshizawa
Bruton's tyrosine kinase (BTK) is a key regulator of the B-cell receptor signaling pathway, and aberrant B-cell receptor (BCR) signaling has been implicated in the survival of malignant B-cells. However, responses of the diffuse large B-cell lymphoma (DLBCL) to inhibitors of BTK (BTKi) are infrequent, highlighting the need to identify mechanisms of resistance to BTKi as well as predictive biomarkers. We investigated the response to the selective BTKi, tirabrutinib, in a panel of 64 hematopoietic cell lines...
April 23, 2018: Cancers
https://www.readbyqxmd.com/read/29683680/tunable-infrared-metasurface-on-a-soft-polymer-scaffold
#9
Jeremy B Reeves, Rachael K Jayne, Thomas J Stark, Lawrence K Barrett, Alice E White, David J Bishop
The fabrication of metallic electromagnetic meta-atoms on a soft microstructured polymer scaffold using a MEMS-based stencil lithography technique is demonstrated. Using this technique, complex metasurfaces that are generally impossible to fabricate with traditional photolithographic techniques are created. By engineering the mechanical deformation of the polymer scaffold, the metasurface reflectivity in the mid-infrared can be tuned by the application of moderate strains.
April 23, 2018: Nano Letters
https://www.readbyqxmd.com/read/29658103/genioglossus-reflex-responses-to-negative-upper-airway-pressure-are-altered-in-people-with-tetraplegia-and-obstructive-sleep-apnoea
#10
Nirupama S Wijesuriya, Laura Gainche, Amy S Jordan, David J Berlowitz, Mariannick LeGuen, Peter D Rochford, Fergal J O'Donoghue, Warren R Ruehland, Jayne C Carberry, Jane E Butler, Danny J Eckert
More than 60% of people with tetraplegia have obstructive sleep apnoea (OSA). However, the specific causes are unknown. Genioglossus, the largest upper-airway dilator muscle, is important in maintaining upper-airway patency. Impaired genioglossus muscle function following spinal cord injury may contribute to OSA. This study aimed to determine if genioglossus reflex responses to negative upper-airway pressure are altered in people with OSA and tetraplegia compared to non-neurologically impaired able-bodied individuals with OSA...
April 15, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29617842/erratum
#11
Stephen P McAdoo, Nicholas Medjeral-Thomas, Seerapani Gopaluni, Anisha Tanna, Nicholas Mansfield, Jack Galliford, Megan Griffith, Jeremy Levy, Thomas D Cairns, David Jayne, Alan D Salama, Charles D Pusey
No abstract text is available yet for this article.
March 30, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29617585/outpatient-talc-administration-by-indwelling-pleural-catheter-for-malignant-effusion
#12
RANDOMIZED CONTROLLED TRIAL
Rahul Bhatnagar, Emma K Keenan, Anna J Morley, Brennan C Kahan, Andrew E Stanton, Mohammed Haris, Richard N Harrison, Rehan A Mustafa, Lesley J Bishop, Liju Ahmed, Alex West, Jayne Holme, Matthew Evison, Mohammed Munavvar, Pasupathy Sivasothy, Jurgen Herre, David Cooper, Mark Roberts, Anur Guhan, Clare Hooper, James Walters, Tarek S Saba, Biswajit Chakrabarti, Samal Gunatilake, Ioannis Psallidas, Steven P Walker, Anna C Bibby, Sarah Smith, Louise J Stadon, Natalie J Zahan-Evans, Y C Gary Lee, John E Harvey, Najib M Rahman, Robert F Miller, Nick A Maskell
BACKGROUND: Malignant pleural effusion affects more than 750,000 persons each year across Europe and the United States. Pleurodesis with the administration of talc in hospitalized patients is the most common treatment, but indwelling pleural catheters placed for drainage offer an ambulatory alternative. We examined whether talc administered through an indwelling pleural catheter was more effective at inducing pleurodesis than the use of an indwelling pleural catheter alone. METHODS: Over a period of 4 years, we recruited patients with malignant pleural effusion at 18 centers in the United Kingdom...
April 5, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29602989/an-in-vivo-analysis-of-safe-laparoscopic-grasping-thresholds-for-colorectal-surgery
#13
Jenifer Barrie, Louise Russell, Adrian J Hood, David G Jayne, Anne Neville, Peter R Culmer
BACKGROUND: Analysis of safe laparoscopic grasping thresholds for the colon has not been performed. This study aimed to analyse tissue damage thresholds when the colon is grasped laparoscopically, correlating histological changes to mechanical compressive forces. METHODS: An instrumented laparoscopic grasper was used to measure the forces applied to porcine colon, with data captured and plotted as a force-time (f-t) curve. Haematoxylin and eosin histochemistry of tissue subjected to 10, 20, 40, 50 and 70 N for 5, 30 and 60 s was performed, and the area of colonic circular and longitudinal muscle was compared in grasped and un-grasped regions...
March 30, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29539274/antifungal-combinations-for-treatment-of-cryptococcal-meningitis-in-africa
#14
RANDOMIZED CONTROLLED TRIAL
Síle F Molloy, Cecilia Kanyama, Robert S Heyderman, Angela Loyse, Charles Kouanfack, Duncan Chanda, Sayoki Mfinanga, Elvis Temfack, Shabir Lakhi, Sokoine Lesikari, Adrienne K Chan, Neil Stone, Newton Kalata, Natasha Karunaharan, Kate Gaskell, Mary Peirse, Jayne Ellis, Chimwemwe Chawinga, Sandrine Lontsi, Jean-Gilbert Ndong, Philip Bright, Duncan Lupiya, Tao Chen, John Bradley, Jack Adams, Charles van der Horst, Joep J van Oosterhout, Victor Sini, Yacouba N Mapoure, Peter Mwaba, Tihana Bicanic, David G Lalloo, Duolao Wang, Mina C Hosseinipour, Olivier Lortholary, Shabbar Jaffar, Thomas S Harrison
BACKGROUND: Cryptococcal meningitis accounts for more than 100,000 human immunodeficiency virus (HIV)-related deaths per year. We tested two treatment strategies that could be more sustainable in Africa than the standard of 2 weeks of amphotericin B plus flucytosine and more effective than the widely used fluconazole monotherapy. METHODS: We randomly assigned HIV-infected adults with cryptococcal meningitis to receive an oral regimen (fluconazole [1200 mg per day] plus flucytosine [100 mg per kilogram of body weight per day] for 2 weeks), 1 week of amphotericin B (1 mg per kilogram per day), or 2 weeks of amphotericin B (1 mg per kilogram per day)...
March 15, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29523766/nucleoside-diphosphate-kinase-3-nme3-enhances-tlr5-induced-nf-%C3%AE%C2%BA-b-activation
#15
Kelly Flentie, Caleb Gonzalez, Brandon Kocher, Yue Wang, Hongtu Zhu, Jayne Marasa, David Piwnica-Worms
Bacterial flagellin is a potent activator of NFκB signaling, inflammation, and host innate immunity, and recent data indicate that flagellin represents a novel antitumor ligand acting through toll-like receptor 5 (TLR5) and the NFκB pathway to induce host immunity and aid in the clearance of tumor xenografts. To identify innate signaling components of TLR5 responsible for these antitumor effects, a loss-of-function high-throughput screen was employed utilizing carcinoma cells expressing a dynamic NFκB bioluminescent reporter stimulated by Salmonella typhimurium expressing flagellin...
March 9, 2018: Molecular Cancer Research: MCR
https://www.readbyqxmd.com/read/29465365/polyarteritis-nodosa-revisited-a-review-of-historical-approaches-subphenotypes-and-a-research-agenda
#16
REVIEW
Omer Karadag, David J Jayne
Polyarteritis nodosa (PAN) is a rare form of primary systemic vasculitis with heterogeneous presentations, treatments and disease course. Historical approaches to classification and diagnostic terminology are reviewed. Since differentiation of PAN from microscopic polyangiitis (MPA) and other ANCA vasculitides by the Chapel Hill conference statements, and with hepatitis associated PAN defined as a secondary vasculitis, the phenotyping and subclassification of PAN has received little attention. Monogenic disorders similar to PAN have been described (familial Mediterranean fever, Adenosine Deaminase-2 deficiency), and cutaneous PAN and single organ vasculitis, discussed...
February 20, 2018: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/29462348/long-term-follow-up-of-a-combined-rituximab-and-cyclophosphamide-regimen-in-renal-anti-neutrophil-cytoplasm-antibody-associated-vasculitis
#17
Stephen P McAdoo, Nicholas Medjeral-Thomas, Seerapani Gopaluni, Anisha Tanna, Nicholas Mansfield, Jack Galliford, Megan Griffith, Jeremy Levy, Thomas D Cairns, David Jayne, Alan D Salama, Charles D Pusey
Background: Current guidelines advise that rituximab or cyclophosphamide should be used for the treatment of organ-threatening disease in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV), although few studies have examined the efficacy and safety of these agents in combination. Methods: We conducted a single-centre cohort study of 66 patients treated with a combination of oral corticosteroids, rituximab and low-dose pulsed intravenous cyclophosphamide followed by a maintenance regimen of azathioprine and tapered steroid for the treatment of biopsy-proven renal involvement in AAV...
February 14, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29422252/achieving-high-quality-standards-in-laparoscopic-colon-resection-for-cancer-a-delphi-consensus-based-position-paper
#18
Laura Lorenzon, Alberto Biondi, Thomas Carus, Adam Dziki, Eloy Espin, Nuno Figueiredo, Marcos Gomez Ruiz, Tamas Mersich, Isacco Montroni, Pieter J Tanis, Stefan Rolf Benz, Paolo Pietro Bianchi, Matthias Biebl, Ivo Broeders, Raffaele De Luca, Paolo Delrio, Mathieu D'Hondt, Alois Fürst, Jan Grosek, Jose Flavio Guimaraes Videira, Friedrich Herbst, David Jayne, György Lázár, Danilo Miskovic, Andrea Muratore, Ole Helmer Sjo, Tom Scheinin, Ales Tomazic, Andreas Türler, Cornelius Van de Velde, Steven D Wexner, Christoph Wullstein, Wojciech Zegarski, Domenico D'Ugo
AIM: To investigate the rate of laparoscopic colectomies for colon cancer using registries and population-based studies. To provide a position paper on mini-invasive (MIS) colon cancer surgery based on the opinion of experts leader in this field. METHODS: A systematic review of the literature was conducted using PRISMA guidelines for the rate of laparoscopy in colon cancer. Moreover, Delphi methodology was used to reach consensus among 35 international experts in four study rounds...
April 2018: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/29417869/a-biomechanical-model-of-the-human-defecatory-system-to-investigate-mechanisms-of-continence
#19
William E Stokes, David G Jayne, Ali Alazmani, Peter R Culmer
This article presents a method to fabricate, measure and control a physical simulation of the human defecatory system to investigate individual and combined effects of anorectal angle and sphincter pressure on continence. To illustrate the capabilities and clinical relevance of the work, the influence of a passive-assistive artificial anal sphincter (FENIXTM ) is evaluated. A model rectum and associated soft tissues, based on geometry from an anonymised computed tomography dataset, was fabricated from silicone and showed behavioural realism to the biological system and ex vivo tissue...
February 1, 2018: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/29385531/comment-on-rituximab-therapy-for-takayasu-arteritis-a-seven-patients-experience-and-a-review-of-the-literature
#20
Daiki Nakagomi, Andreas Kronbichler, Torsten Witte, Aladdin J Mohammad, David R W Jayne
No abstract text is available yet for this article.
January 29, 2018: Rheumatology
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