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David Jayne

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https://www.readbyqxmd.com/read/27921386/cytotoxicity-of-a-series-of-norcantharidin-inspired-tetrahydroepoxyisoindole-carboxamides
#1
Christopher Peter Gordon, Lawson K Spare, Pasquale Falsetta, Jayne Gilbert, David G Harman, Mark A Baker, Feng Li, Adam McCluskey, Jack K Clegg, Jennette A Sakoff, Janice R Aldrich-Wright
A series of 28 norcantharidin (NorC) inspired analogues were accessed via a robust two-step Ugi intramolecular Diels-Alder (IMDA) sequence. Four analogues displayed equipotent whole cell cytotoxicity to NorC and cisplatin against a number of cancer cell lines and a normal breast cell line (MCF10A). Notably (3S,3aS,6R)-2-benzyl-7-methyl-N-(naphthalen-2-yl)-1-oxo-1,2,3,6-tetrahydro-3a,6-epoxyisoindole-3-carboxamide (trans-27) displayed superior whole cell activity against breast (MCF-7, GI50 = 2.9 µM) and colon (HT29, GI50 = 6...
December 6, 2016: ChemMedChem
https://www.readbyqxmd.com/read/27899372/effect-of-rituximab-on-malignancy-risk-in-patients-with-anca-associated-vasculitis
#2
Emma E van Daalen, Raffaella Rizzo, Andreas Kronbichler, Ron Wolterbeek, Jan A Bruijn, David R Jayne, Ingeborg M Bajema, Chinar Rahmattulla
OBJECTIVES: Patients with antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) treated with cyclophosphamide have an increased malignancy risk compared with the general population. We investigated whether treatment with rituximab instead of cyclophosphamide has decreased the malignancy risk in patients with AAV. METHODS: The study included patients with AAV treated at a tertiary vasculitis referral centre between 2000 and 2014. The malignancy incidence in these patients was compared with the incidence in the general population by calculating standardised incidence ratios (SIRs), adjusted for sex, age and calendar year...
November 29, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27884822/a-framework-for-remission-in-sle-consensus-findings-from-a-large-international-task-force-on-definitions-of-remission-in-sle-doris
#3
Ronald van Vollenhoven, Alexandre Voskuyl, George Bertsias, Cynthia Aranow, Martin Aringer, Laurent Arnaud, Anca Askanase, Petra Balážová, Eloisa Bonfa, Hendrika Bootsma, Dimitrios Boumpas, Ian Bruce, Ricard Cervera, Ann Clarke, Cindy Coney, Nathalie Costedoat-Chalumeau, László Czirják, Ronald Derksen, Andrea Doria, Thomas Dörner, Rebecca Fischer-Betz, Ruth Fritsch-Stork, Caroline Gordon, Winfried Graninger, Noémi Györi, Frédéric Houssiau, David Isenberg, Soren Jacobsen, David Jayne, Annegret Kuhn, Veronique Le Guern, Kirsten Lerstrøm, Roger Levy, Francinne Machado-Ribeiro, Xavier Mariette, Jamil Missaykeh, Eric Morand, Marta Mosca, Murat Inanc, Sandra Navarra, Irmgard Neumann, Marzena Olesinska, Michelle Petri, Anisur Rahman, Ole Petter Rekvig, Jozef Rovensky, Yehuda Shoenfeld, Josef Smolen, Angela Tincani, Murray Urowitz, Bernadette van Leeuw, Carlos Vasconcelos, Anne Voss, Victoria P Werth, Helena Zakharova, Asad Zoma, Matthias Schneider, Michael Ward
OBJECTIVES: Treat-to-target recommendations have identified 'remission' as a target in systemic lupus erythematosus (SLE), but recognise that there is no universally accepted definition for this. Therefore, we initiated a process to achieve consensus on potential definitions for remission in SLE. METHODS: An international task force of 60 specialists and patient representatives participated in preparatory exercises, a face-to-face meeting and follow-up electronic voting...
November 24, 2016: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/27821281/molecular-determinants-of-sulfadoxine-pyrimethamine-resistance-in-plasmodium-falciparum-in-nigeria-and-the-regional-emergence-of-dhps-431v
#4
Mary C Oguike, Catherine O Falade, Elvis Shu, Izehiuwa G Enato, Ismaila Watila, Ebenezer S Baba, Jane Bruce, Jayne Webster, Prudence Hamade, Sylvia Meek, Daniel Chandramohan, Colin J Sutherland, David Warhurst, Cally Roper
There are few published reports of mutations in dihydropteroate synthetase (dhps) and dihydrofolate reductase (dhfr) genes in P. falciparum populations in Nigeria, but one previous study has recorded a novel dhps mutation at codon 431 among infections imported to the United Kingdom from Nigeria. To assess how widespread this mutation is among parasites in different parts of the country and consequently fill the gap in sulfadoxine-pyrimethamine (SP) resistance data in Nigeria, we retrospectively analysed 1000 filter paper blood spots collected in surveys of pregnant women and children with uncomplicated falciparum malaria between 2003 and 2015 from four sites in the south and north...
September 29, 2016: International Journal for Parasitology, Drugs and Drug Resistance
https://www.readbyqxmd.com/read/27803133/comparison-of-the-phenotype-and-outcome-of-granulomatosis-with-polyangiitis-between-uk-and-japanese-cohorts
#5
Shunsuke Furuta, Afzal N Chaudhry, Yoshihiro Arimura, Hiroaki Dobashi, Shouichi Fujimoto, Sakae Homma, Niels Rasmussen, David R Jayne
OBJECTIVE: There are differences in the frequencies of antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis subgroups between different geographic regions, and we have reported differences in the phenotype of microscopic polyangiitis between Europe and Japan. In this retrospective observational study, we compared phenotypes and outcomes of granulomatosis with polyangiitis (GPA) between the United Kingdom and Japan. METHODS: We identified 128 UK and 82 Japanese patients with GPA diagnosed between 2000 and 2012...
November 1, 2016: Journal of Rheumatology
https://www.readbyqxmd.com/read/27788131/the-impact-of-environmental-and-endogenous-damage-on-somatic-mutation-load-in-human-skin-fibroblasts
#6
Natalie Saini, Steven A Roberts, Leszek J Klimczak, Kin Chan, Sara A Grimm, Shuangshuang Dai, David C Fargo, Jayne C Boyer, William K Kaufmann, Jack A Taylor, Eunjung Lee, Isidro Cortes-Ciriano, Peter J Park, Shepherd H Schurman, Ewa P Malc, Piotr A Mieczkowski, Dmitry A Gordenin
ClinicalTrials.gov NCT01087307.
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27780742/association-of-a-tnfsf13b-baff-regulatory-region-single-nucleotide-polymorphism-with-response-to-rituximab-in-anca-associated-vasculitis
#7
Federico Alberici, Rona M Smith, Mariana Fonseca, Lisa C Willcocks, Rachel B Jones, Julia U Holle, Stefan Wieczorek, Thomas Neumann, Davide Martorana, Gina Gregorini, Renato A Sinico, Annette Bruchfeld, Iva Gunnarsson, Sophie Ohlsson, Bo Baslund, Vladimir Tesar, Zdenka Hruskova, Maria C Cid, Augusto Vaglio, Paul A Lyons, Kenneth G C Smith, David R W Jayne
In ANCA-associated vasculitis (AAVs) response to rituximab is highly variable and predictors of response are needed. Our study identifies a single nucleotide polymorphism of the regulatory region of TNFSF13B (BAFF) associated with response to rituximab in AAV.
October 22, 2016: Journal of Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/27769191/protocol-of-the-low-birth-weight-south-asia-trial-lbwsat-a-cluster-randomised-controlled-trial-testing-impact-on-birth-weight-and-infant-nutrition-of-participatory-learning-and-action-through-women-s-groups-with-and-without-unconditional-transfers-of-fortified
#8
Naomi M Saville, Bhim P Shrestha, Sarah Style, Helen Harris-Fry, B James Beard, Aman Sengupta, Sonali Jha, Anjana Rai, Vikas Paudel, Anni-Maria Pulkki-Brannstrom, Andrew Copas, Jolene Skordis-Worrall, Bishnu Bhandari, Rishi Neupane, Joanna Morrison, Lu Gram, Raghbendra Sah, Machhindra Basnet, Jayne Harthan, Dharma S Manandhar, David Osrin, Anthony Costello
BACKGROUND: Low birth weight (LBW, < 2500 g) affects one third of newborn infants in rural south Asia and compromises child survival, infant growth, educational performance and economic prospects. We aimed to assess the impact on birth weight and weight-for-age Z-score in children aged 0-16 months of a nutrition Participatory Learning and Action behaviour change strategy (PLA) for pregnant women through women's groups, with or without unconditional transfers of food or cash to pregnant women in two districts of southern Nepal...
October 21, 2016: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/27727451/postoperative-radiotherapy-for-non-small-cell-lung-cancer
#9
REVIEW
Sarah Burdett, Larysa Rydzewska, Jayne Tierney, David Fisher, Mahesh Kb Parmar, Rodrigo Arriagada, Jean Pierre Pignon, Cecile Le Pechoux
BACKGROUND: The role of postoperative radiotherapy (PORT) in the treatment of patients with completely resected non-small cell lung cancer (NSCLC) was not clear. A systematic review and individual participant data meta-analysis was undertaken to evaluate available evidence from randomised controlled trials (RCTs). These results were first published in Lung Cancer in 2013. OBJECTIVES: To evaluate the effects of PORT on survival and recurrence in patients with completely resected NSCLC...
October 11, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27714705/predictive-factors-of-bleeding-events-in-adults-undergoing-extracorporeal-membrane-oxygenation
#10
Cécile Aubron, Joris DePuydt, François Belon, Michael Bailey, Matthieu Schmidt, Jayne Sheldrake, Deirdre Murphy, Carlos Scheinkestel, D Jamie Cooper, Gilles Capellier, Vincent Pellegrino, David Pilcher, Zoe McQuilten
BACKGROUND: Bleeding is the most frequent complication associated with extracorporeal membrane oxygenation (ECMO) support in critically ill patients. Nonetheless, risk factors for bleeding have been poorly described especially those associated with coagulation anomalies and anticoagulant therapy during ECMO support. The aim of this study is to describe bleeding complications in critically ill patients undergoing ECMO and to identify risk factors for bleeding events. METHODS: We retrospectively analysed ICU charts of adults who received either veno-venous (VV) or veno-arterial (VA) ECMO support in two participating ICUs between 2010 and 2013...
December 2016: Annals of Intensive Care
https://www.readbyqxmd.com/read/27707245/reneb-running-the-european-network-of-biological-dosimetry-and-physical-retrospective-dosimetry
#11
Ulrike Kulka, Michael Abend, Elizabeth Ainsbury, Christophe Badie, Joan Francesc Barquinero, Lleonard Barrios, Christina Beinke, Emanuela Bortolin, Alexandra Cucu, Andrea De Amicis, Inmaculada Domínguez, Paola Fattibene, Anne Marie Frøvig, Eric Gregoire, Kamile Guogyte, Valeria Hadjidekova, Alicja Jaworska, Ralf Kriehuber, Carita Lindholm, David Lloyd, Katalin Lumniczky, Fiona Lyng, Roberta Meschini, Simone Mörtl, Sara Della Monaca, Octávia Monteiro Gil, Alegria Montoro, Jayne Moquet, Mercedes Moreno, Ursula Oestreicher, Fabrizio Palitti, Gabriel Pantelias, Clarice Patrono, Laure Piqueret-Stephan, Matthias Port, María Jesus Prieto, Roel Quintens, Michelle Ricoul, Horst Romm, Laurence Roy, Géza Sáfrány, Laure Sabatier, Natividad Sebastià, Sylwester Sommer, Georgia Terzoudi, Antonella Testa, Hubert Thierens, Istvan Turai, François Trompier, Marco Valente, Pedro Vaz, Philippe Voisin, Anne Vral, Clemens Woda, Demetre Zafiropoulos, Andrzej Wojcik
PURPOSE: A European network was initiated in 2012 by 23 partners from 16 European countries with the aim to significantly increase individualized dose reconstruction in case of large-scale radiological emergency scenarios. RESULTS: The network was built on three complementary pillars: (1) an operational basis with seven biological and physical dosimetric assays in ready-to-use mode, (2) a basis for education, training and quality assurance, and (3) a basis for further network development regarding new techniques and members...
October 6, 2016: International Journal of Radiation Biology
https://www.readbyqxmd.com/read/27703758/protocol-investigating-the-clinical-outcomes-and-cost-effectiveness-of-cognitive-behavioural-therapy-delivered-remotely-for-unscheduled-care-users-with-health-anxiety-randomised-controlled-trial
#12
Shireen Patel, Sam Malins, Boliang Guo, Marilyn James, Joe Kai, Catherine Kaylor-Hughes, Emma Rowley, Jayne Simpson, David Smart, Michelle Stubley, Helen Tyrer, Richard Morriss
BACKGROUND: Health anxiety and medically unexplained symptoms cost the National Health Service (NHS) an estimated £3 billion per year in unnecessary costs with little evidence of patient benefit. Effective treatment is rarely taken up due to issues such as stigma or previous negative experiences with mental health services. An approach to overcome this might be to offer remotely delivered psychological therapy, which can be just as effective as face-to-face therapy and may be more accessible and suitable...
January 2016: BJPsych Open
https://www.readbyqxmd.com/read/27684386/postoperative-radiotherapy-for-non-small-cell-lung-cancer
#13
Sarah Burdett, Larysa Rydzewska, Jayne Tierney, David Fisher, Mahesh Kb Parmar, Rodrigo Arriagada, Jean Pierre Pignon, Cecile Le Pechoux
BACKGROUND: The role of postoperative radiotherapy (PORT) in the treatment of patients with completely resected non-small cell lung cancer (NSCLC) was not clear. A systematic review and individual participant data meta-analysis was undertaken to evaluate available evidence from randomised controlled trials (RCTs). These results were first published in Lung Cancer in 2013. OBJECTIVES: To evaluate the effects of PORT on survival and recurrence in patients with completely resected NSCLC...
September 29, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27683730/opponent-s-comments
#14
Maria Fernandez Nieto, David R Jayne
No abstract text is available yet for this article.
October 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27671089/revisiting-the-systemic-vasculitis-in-eosinophilic-granulomatosis-with-polyangiitis-churg-strauss-a-study-of-157-patients-by-the-groupe-d-etudes-et-de-recherche-sur-les-maladies-orphelines-pulmonaires-and-the-european-respiratory-society-taskforce-on-eosinophilic
#15
Vincent Cottin, Elisabeth Bel, Paolo Bottero, Klaus Dalhoff, Marc Humbert, Romain Lazor, Renato A Sinico, Pasupathy Sivasothy, Michael E Wechsler, Matthieu Groh, Sylvain Marchand-Adam, Chahéra Khouatra, Benoit Wallaert, Camille Taillé, Philippe Delaval, Jacques Cadranel, Philippe Bonniaud, Grégoire Prévot, Sandrine Hirschi, Anne Gondouin, Bertrand Dunogué, Gérard Chatté, Christophe Briault, Christian Pagnoux, David Jayne, Loïc Guillevin, Jean-François Cordier
OBJECTIVE: To guide nosology and classification of patients with eosinophilic granulomatosis with polyangiitis (EGPA) based on phenotype and presence or absence of ANCA. METHODS: Organ manifestations and ANCA status were retrospectively analyzed based on the presence or not of predefined definite vasculitis features or surrogates of vasculitis in patients asthma, eosinophilia, and at least one systemic organ manifestation attributable to systemic disease. RESULTS: The study population included 157 patients (mean age 49...
September 23, 2016: Autoimmunity Reviews
https://www.readbyqxmd.com/read/27647854/the-genetic-landscape-of-renal-complications-in-type-1-diabetes
#16
Niina Sandholm, Natalie Van Zuydam, Emma Ahlqvist, Thorhildur Juliusdottir, Harshal A Deshmukh, N William Rayner, Barbara Di Camillo, Carol Forsblom, Joao Fadista, Daniel Ziemek, Rany M Salem, Linda T Hiraki, Marcus Pezzolesi, David Trégouët, Emma Dahlström, Erkka Valo, Nikolay Oskolkov, Claes Ladenvall, M Loredana Marcovecchio, Jason Cooper, Francesco Sambo, Alberto Malovini, Marco Manfrini, Amy Jayne McKnight, Maria Lajer, Valma Harjutsalo, Daniel Gordin, Maija Parkkonen, Jaakko Tuomilehto, Valeriya Lyssenko, Paul M McKeigue, Stephen S Rich, Mary Julia Brosnan, Eric Fauman, Riccardo Bellazzi, Peter Rossing, Samy Hadjadj, Andrzej Krolewski, Andrew D Paterson, Jose C Florez, Joel N Hirschhorn, Alexander P Maxwell, David Dunger, Claudio Cobelli, Helen M Colhoun, Leif Groop, Mark I McCarthy, Per-Henrik Groop
Diabetes is the leading cause of ESRD. Despite evidence for a substantial heritability of diabetic kidney disease, efforts to identify genetic susceptibility variants have had limited success. We extended previous efforts in three dimensions, examining a more comprehensive set of genetic variants in larger numbers of subjects with type 1 diabetes characterized for a wider range of cross-sectional diabetic kidney disease phenotypes. In 2843 subjects, we estimated that the heritability of diabetic kidney disease was 35% (P=6...
September 19, 2016: Journal of the American Society of Nephrology: JASN
https://www.readbyqxmd.com/read/27614983/early-bilateral-gonadoblastoma-in-a-young-child-with-mosaicism-for-turner-syndrome-and-trisomy-18-with-y-chromosome
#17
Jayne M MacMahon, Maureen J O'Sullivan, Michael McDermott, Feargal Quinn, Thomas Morris, Andrew J Green, David R Betts, Susan M O'Connell
Mosaic Turner syndrome (TSM) commonly occurs in the form of 45,X/46,XX and 45,X/46,X,i(X)(q10). Mosaicism for a Y chromosome, 45,X/46,XY, has been well documented and is associated with increased risk of gonadoblastoma (GB). To date, there are only six reported cases of TSM with a trisomy 18 karyotype, and only two of these were phenotypically female with 45,X/47,XY,+18 karyotype. We present the case of a phenotypically female infant born with dysmorphic features. G-banded karyotype and interphase FISH of blood showed 45,X in 95% and 47,XY,+18 (trisomy 18) in 5% of cells analysed...
September 10, 2016: Hormone Research in Pædiatrics
https://www.readbyqxmd.com/read/27606948/is-there-a-relationship-between-gluten-sensitivity-and-postural-tachycardia-syndrome
#18
Hugo A Penny, Imran Aziz, Melloney Ferrar, Jayne Atkinson, Nigel Hoggard, Marios Hadjivassiliou, John N West, David S Sanders
BACKGROUND: We have noticed that patients with postural tachycardia syndrome (PoTS) were placing themselves on a gluten-free diet without medical consultation. Therefore, we aimed to evaluate the prevalence of coeliac disease and self-reported gluten sensitivity in a cohort of patients with PoTS and compare this with local population data. METHODS: A total of 100 patients with PoTS were recruited to complete a questionnaire that screened for gluten sensitivity, related symptoms and dietary habits...
September 7, 2016: European Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/27603906/thyroid-function-within-the-reference-range-and-the-risk-of-stroke-an-individual-participant-data-analysis
#19
Layal Chaker, Christine Baumgartner, Wendy P J den Elzen, Tinh-Hai Collet, M Arfan Ikram, Manuel R Blum, Abbas Dehghan, Christiane Drechsler, Robert N Luben, Marileen L P Portegies, Giorgio Iervasi, Marco Medici, David J Stott, Robin P Dullaart, Ian Ford, Alexandra Bremner, Anne B Newman, Christoph Wanner, José A Sgarbi, Marcus Dörr, W T Longstreth, Bruce M Psaty, Luigi Ferrucci, Rui M B Maciel, Rudi G Westendorp, J Wouter Jukema, Graziano Ceresini, Misa Imaizumi, Albert Hofman, Stephan J L Bakker, Jayne A Franklyn, Kay-Tee Khaw, Douglas C Bauer, John P Walsh, Salman Razvi, Jacobijn Gussekloo, Henry Völzke, Oscar H Franco, Anne R Cappola, Nicolas Rodondi, Robin P Peeters
CONTEXT: The currently applied reference ranges for thyroid function are under debate. Despite evidence that thyroid function within the reference range is related with several cardiovascular disorders, its association with the risk of stroke has not been evaluated previously. DESIGN AND SETTING: We identified studies through a systematic literature search and the Thyroid Studies Collaboration, a collaboration of prospective cohort studies. Studies measuring baseline TSH, free T4, and stroke outcomes were included, and we collected individual participant data from each study, including thyroid function measurements and incident all stroke (combined fatal and nonfatal) and fatal stroke...
November 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27595142/infliximab-versus-ciclosporin-for-steroid-resistant-acute-severe-ulcerative-colitis-construct-a-mixed-methods-open-label-pragmatic-randomised-trial
#20
John G Williams, M Fasih Alam, Laith Alrubaiy, Ian Arnott, Clare Clement, David Cohen, John N Gordon, A Barney Hawthorne, Mike Hilton, Hayley A Hutchings, Aida U Jawhari, Mirella Longo, John Mansfield, Jayne M Morgan, Frances Rapport, Anne C Seagrove, Shaji Sebastian, Ian Shaw, Simon P L Travis, Alan Watkins
BACKGROUND: Infliximab and ciclosporin are of similar efficacy in treating acute severe ulcerative colitis, but there has been no comparative evaluation of their relative clinical effectiveness and cost-effectiveness. METHODS: In this mixed methods, open-label, pragmatic randomised trial, we recruited consenting patients aged 18 years or older at 52 district general and teaching hospitals in England, Scotland, and Wales who had been admitted, unscheduled, with severe ulcerative colitis and failed to respond to intravenous hydrocortisone within about 5 days...
September 2016: Lancet. Gastroenterology & Hepatology
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