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https://www.readbyqxmd.com/read/28551793/mitochondria-in-structural-and-functional-cardiac-remodeling
#1
Natalia Torrealba, Pablo Aranguiz, Camila Alonso, Beverly A Rothermel, Sergio Lavandero
The heart must function continuously as it is responsible for both supplying oxygen and nutrients throughout the entire body, as well as for the transport of waste products to excretory organs. When facing either a physiological or pathological increase in cardiac demand, the heart undergoes structural and functional remodeling as a means of adapting to increased workload. These adaptive responses can include changes in gene expression, protein composition, and structure of sub-cellular organelles involved in energy production and metabolism...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/28551644/clinical-assessment-of-sarcopenia-and-changes-in-body-composition-during-neoadjuvant-chemotherapy-for-esophageal-cancer
#2
Hiroshi Miyata, Keijiro Sugimura, Masaaki Motoori, Yoshiyuki Fujiwara, Takeshi Omori, Yoshitomo Yanagimoto, Masayuki Ohue, Masayoshi Yasui, Norikatsu Miyoshi, Akira Tomokuni, Hirofumi Akita, Shogo Kobayashi, Hidenori Takahashi, Masahiko Yano
AIM: The aim of this study was to assess changes in body composition during neoadjuvant chemotherapy (NAC) and investigate whether chemotherapy-related toxicities affect body composition in patients with esophageal cancer. PATIENTS AND METHODS: In ninety-four patients who underwent NAC for esophageal cancer, body composition was assessed before and after NAC. Associations between the incidence of toxicities and change in body composition during NAC were investigated...
June 2017: Anticancer Research
https://www.readbyqxmd.com/read/28551577/bioactive-growth-hormone-in-older-men-and-women-it-s-relationship-to-immune-markers-and-healthspan
#3
William J Kraemer, Mary J Kennett, Andrea M Mastro, Roger J McCarter, Connie J Rogers, William H DuPont, Shawn D Flanagan, William J Turbitt, Maren S Fragala, Emily M Post, Wesley C Hymer
OBJECTIVE: The consequences of age-related decline in the somatotropic axis of humans are complex and remain largely unresolved. We tested the hypothesis that hGH measurements of plasma by bioassay vs immunoassay from samples obtained from free-living, elderly individuals would reveal a dichotomy in GH activities that are correlated with the functional status of the donors, i.e. their healthspan. DESIGN: Forty-one men and women of advanced age (men: N=16, age, 80...
May 8, 2017: Growth Hormone & IGF Research
https://www.readbyqxmd.com/read/28551406/protective-effect-of-hesperidin-and-tiger-nut-against-acrylamide-toxicity-in-female-rats
#4
Soha M Hamdy, Amany M Shabaan, Abdel Karim M Abdel Latif, Ayman M Abdel-Aziz, Alshimaa M Amin
Phytochemicals that have antioxidant effect play important role in protection against several diseases in humans. This study was carried out to evaluate the efficacy of hesperidin and tiger nut against the early changes that may be related to the toxicity of acrylamide in female rats. 72 Sprague Dawley female rats were divided into six groups (12 rat/group): control group (I); hesperidin (HES) treated group (II); tiger nut (TN) treated group (III); Acrylamide (ACR) treated group (IV); HES-ACR treated group (V); and TN-ACR treated group (VI)...
May 24, 2017: Experimental and Toxicologic Pathology: Official Journal of the Gesellschaft Für Toxikologische Pathologie
https://www.readbyqxmd.com/read/28551183/comparison-of-2-recommendations-for-adjusting-the-working-height-in-milking-parlors
#5
Martina C Jakob, Falk Liebers
Milking cows is one of the major labor inputs on dairy farms. Modern parlors allow upright working positions, but pain and disorders among parlor workers are still very prevalent. The platform height in the parlors is important for the body posture of the workers. Based on a large set of data containing parlor-specific measures, anthropometrics, and bovimetrics, a simulation of 2 recommendations published in the literature was carried out. This article presents and discusses the results of 2 formulas for determining the appropriate pit depth...
May 24, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28550501/grass-carp-reovirus-gd108-fiber-protein-is-involved-in-cell-attachment
#6
Yuanyuan Tian, Zhenzhen Jiao, Junjian Dong, Chengfei Sun, Xiaoyan Jiang, Xing Ye
Viral attachment to specific host receptors is the first step in viral infection and serves an essential function in the selection of target cells. In this study, structure analysis, neutralization assays, and cell attachment assays were carried out to evaluate the cell attachment functions of the outer capsid fiber protein of grass carp reovirus GD108 strain (GCRV-GD108). The GCRV-GD108 fiber protein contained 512 amino acids encoded by S7 segment and shared sequence similarities with mammalian reovirus cell attachment protein σ1 and adenovirus fiber...
May 26, 2017: Virus Genes
https://www.readbyqxmd.com/read/28549731/clinical-and-sonographic-biomarkers-of-structural-damage-progression-in-ra-patients-in-clinical-remission-a-prospective-study-with-12-months-follow-up
#7
Julio Ramírez, José Antonio Narváez, Virginia Ruiz-Esquide, Javier Hernández-Gañán, Andrea Cuervo, José Inciarte-Mundo, Maria Victoria Hernández, Miguel Sampayo-Cordero, José Luis Pablos, Raimon Sanmartí, Juan D Cañete
OBJECTIVE: To determine clinical and sonographic biomarkers predicting structural damage progression at 12 months of follow-up as measured by magnetic resonance imaging (MRI) in rheumatoid arthritis (RA) patients in clinical remission. PATIENTS AND METHODS: We included patients with RA in clinical remission, defined as 28-joint disease activity score (DAS28)-erythrocyte sedimentation rate (ESR) <2.6 for >6 months. Ultrasound scans of both hands and knees and MRI of the dominant hand were performed at baseline and at 12 months...
May 1, 2017: Seminars in Arthritis and Rheumatism
https://www.readbyqxmd.com/read/28549547/a-systematic-review-on-ricochet-gunshot-injuries
#8
REVIEW
Yuw-Er Yong
Ricocheted bullets may still retain sufficient kinetic energy to cause gunshot injuries. Accordingly, this paper reviews the literature surrounding gunshot injuries caused by ricocheted bullets. In doing so, it discusses the characteristics of ricochet entrance wounds and wound tracks, noting several important considerations for assessment of a possible ricochet incident. The shapes of ricochet entrance wounds vary, ranging from round holes to elliptical, large and irregular shapes. Pseudo-stippling or pseudo-gunpowder tattooing, pseudo-soot blackening and tumbling abrasions seen on the skin surrounding the bullet hole are particularly associated with ricochet incidents...
May 2017: Legal Medicine
https://www.readbyqxmd.com/read/28549470/rationale-and-protocol-paper-for-the-healthy-active-peaceful-playgrounds-for-youth-happy-study
#9
Wayne Cotton, Dean Dudley, Kirsten Jackson, Matthew Winslade, Janice Atkin
BACKGROUND: A growing body of evidence suggest an association between physical activity levels and students psychological well-being. A number of research studies have evaluated playground interventions that aim to increase physical activity levels, decrease conflict and bullying, and improve students behaviour. The HAPPY Study will evaluate the success of an intervention combining environmental modifications, teacher development, and peer support that can culminate in an easy to implement, low cost and effective model for increasing physical activity, and improving psychological well-being for children...
May 26, 2017: BMC Public Health
https://www.readbyqxmd.com/read/28549455/inter-act-prevention-of-pregnancy-complications-through-an-e-health-driven-interpregnancy-lifestyle-intervention-study-protocol-of-a-multicentre-randomised-controlled-trial
#10
Annick Bogaerts, Lieveke Ameye, Margriet Bijlholt, Kelly Amuli, Dorine Heynickx, Roland Devlieger
BACKGROUND: Excessive maternal pre-pregnancy and gestational weight gain are related to pregnancy- and birth outcomes. The interpregnancy time window offers a unique opportunity to intervene in order to acquire a healthy lifestyle before the start of a new pregnancy. METHODS: INTER-ACT is an e-health driven multicentre randomised controlled intervention trial targeting women at high risk of pregnancy- and birth related complications. Eligible women are recruited for the study at day 2 or 3 postpartum...
May 26, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/28549202/polymorphism-in-the-beta-casein-gene-and-analysis-of-milk-characteristicsin-gir-and-guzer%C3%A3-dairy-cattle
#11
A H N Rangel, L G Zaros, T C Lima, L H F Borba, L P Novaes, L F M Mota, M S Silva
Several human health problems have been related to the allergenic constitution of bovine milk due to the body's immune reaction to milk proteins. It is necessary find solutions to minimize the occurrence of such reactions, given the importance of milk as a source of animal protein. The aim of this study was to evaluate the allelic frequency of the CSN2 gene and to evaluate differences in the characteristics of Gir and Guzerá bovine milk. One hundred and fifty-six cows were used (68 Gir and 88 Guzerá) from the Felipe Camarão Experimental Station herd of the Agricultural Research Corporation of RN (EMPARN)...
May 25, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28549109/il-18-cleavage-triggers-cardiac-inflammation-and-fibrosis-upon-%C3%AE-adrenergic-insult
#12
Han Xiao, Hao Li, Jing-Jing Wang, Jian-Shu Zhang, Jing Shen, Xiang-Bo An, Cong-Cong Zhang, Ji-Min Wu, Yao Song, Xin-Yu Wang, Hai-Yi Yu, Xiang-Ning Deng, Zi-Jian Li, Ming Xu, Zhi-Zhen Lu, Jie Du, Wei Gao, Ai-Hua Zhang, Yue Feng, You-Yi Zhang
Aims: Rapid over-activation of β-adrenergic receptor (β-AR) upon stress leads to cardiac inflammation, a prevailing factor that underlies heart injury. However, mechanisms by which acute β-AR stimulation induce cardiac inflammation still remain unknown. Here, we set out to identify the crucial role of inflammasome/interleukin (IL)-18 in initiating and maintaining cardiac inflammatory cascades upon β-AR insult. Methods and results: Male C57BL/6 mice were injected with a single dose of β-AR agonist, isoproterenol (ISO, 5 mg/kg body weight) or saline subcutaneously...
May 26, 2017: European Heart Journal
https://www.readbyqxmd.com/read/28549062/reproductive-endocrinology-cycling-through-the-menstrual-cycle-an-out-of-body-experience
#13
Donald E Ingber
No abstract text is available yet for this article.
May 26, 2017: Nature Reviews. Endocrinology
https://www.readbyqxmd.com/read/28549046/associations-of-physical-fitness-and-body-composition-characteristics-with-simulated-military-task-performance
#14
K Pihlainen, M Santtila, K Häkkinen, H Kyröläinen
The purpose of the present study was to evaluate the associations of physical fitness and body composition characteristics with anaerobic endurance performance, tested in the combat load using the occupationally relevant military simulation test (MST). Eighty-one male soldiers, deployed to a crisis management operation in the Middle East, volunteered for the study and participated in a test battery consisting measurements of muscle strength, body composition characteristics, endurance capacity, and MST.A Spearman correlational analysis revealed that the strongest variable, correlated with MST time, was the countermovement jump performed with the combat load (CMJ2) (rs = -0...
May 25, 2017: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/28548897/evening-light-exposure-to-computer-screens-disrupts-human-sleep-biological-rhythms-and-attention-abilities
#15
A Green, M Cohen-Zion, A Haim, Y Dagan
The use of electronic devices with light-emitting screens has increased exponentially in the last decade. As a result, humans are almost continuously exposed to unintentional artificial light. We explored the independent and combined effects of two aspects of screen illumination, light wavelength, and intensity, on sleep, its biological regulation, and related functional outcomes. The 2 × 2 repeated-measure design included two independent variables: screen light intensity (low ([LI] versus high [HI]) and wavelength (short [SWL] versus long [LWL])...
May 26, 2017: Chronobiology International
https://www.readbyqxmd.com/read/28548528/typical-relaxation-of-isolated-many-body-systems-which-do-not-thermalize
#16
Ben N Balz, Peter Reimann
We consider isolated many-body quantum systems which do not thermalize; i.e., expectation values approach an (approximately) steady longtime limit which disagrees with the microcanonical prediction of equilibrium statistical mechanics. A general analytical theory is worked out for the typical temporal relaxation behavior in such cases. The main prerequisites are initial conditions which appreciably populate many energy levels and do not give rise to significant spatial inhomogeneities on macroscopic scales...
May 12, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28548458/effector-based-attention-systems
#17
REVIEW
Carolyn J Perry, Mazyar Fallah
Visual processing is known to be enhanced at the end point of eye movements. Feedback within the oculomotor system has been shown to drive these alterations in visual processing. However, we do not simply view the world; we also reach out and interact using our hands. Consequently, it is not surprising that visual processing has also been shown to be altered in near-hand space. A growing body of work documents a myriad of alterations in near-hand visual processing, with little consensus on the neural underpinnings of the effect of the hand...
May 2017: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/28548189/-physical-activity-obesity-and-self-esteem-in-chilean-schoolchildren
#18
Félix Zurita-Ortega, Manuel Castro-Sánchez, Sonia Rodríguez-Fernández, Cristian Cofré-Boladós, Ramón Chacón-Cuberos, Asunción Martínez-Martínez, José Joaquín Muros-Molina
BACKGROUND: Obesity is a worldwide epidemic disease and a problem for the Chilean society. AIM: To analyze the relationship between physical condition, body mass index (BMI), level of physical activity and self-esteem. Material ad Methods: Questionnaires to assess self-esteem (Rosemberg scale) and levels of physical activity (Physical Activity Questionnaire for older Children, PAQ-C) were answered by 515 children aged 10.5 ± 0.5 years from 27 schools of Santiago de Chile...
March 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28546741/sj%C3%A3-gren-s-syndrome-is-associated-with-negatively-variable-impacts-on-domains-of-health-related-quality-of-life-evidence-from-short-form-36-questionnaire-and-a-meta-analysis
#19
REVIEW
Qiuxiang Zhang, Xulin Wang, Haoyang Chen, Biyu Shen
PURPOSE: The purpose of this article was to systematically review the literature to identify the impact of primary Sjögren's syndrome (pSS) on specific health-related quality of life (HRQoL) domains. METHODS: A meta-analysis was performed, and the related articles were searched in Medline, Embase, Cochrane Library, China National Knowledge Infrastructure, China Biology Medicine, and Web of Science databases and in reference lists of articles and systematic reviews...
2017: Patient Preference and Adherence
https://www.readbyqxmd.com/read/28545187/enterolactone-suppresses-proliferation-migration-and-metastasis-of-mda-mb-231-breast-cancer-cells-through-inhibition-of-upa-induced-plasmin-activation-and-mmps-mediated-ecm-remodeling
#20
Aniket V Mali, Asavari A Joshi, Mahabaleshwar V Hegde, Shivajirao S Kadam
Background: To enhance their own survival, tumor cells can manipulate their microenvironment through remodeling of the extra cellular matrix (ECM). The urokinase-type plasminogen activator (uPA) system catalyzes plasmin production which further mediates activation of matrix metalloproteinases (MMPs) and plays an important role in breast cancer invasion and metastasis through ECM remodeling. This provides a potential target for therapeutic intervention of breast cancer treatment. Enterolactone (EL) is derived from dietary flax lignans in the human body and is known to have anti-breast cancer activity...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
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