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adenosquamous pancreas

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https://www.readbyqxmd.com/read/28979722/pancreatic-adenosquamous-carcinoma-and-intraductal-papillary-mucinous-neoplasm-in-a-cdkn2a-germline-mutation-carrier
#1
Fernando Martínez de Juan, María Reolid Escribano, Carmen Martínez Lapiedra, Fernanda Maia de Alcantara, María Caballero Soto, Ana Calatrava Fons, Isidro Machado
A 69-year-old woman from a kindred with familial atypical multiple mole melanoma and carrier of a germline mutation in CDKN2A, presented with abdominal pain caused by a solid-cystic pancreatic mass. The patient had an abdominal computed tomography three years before in which there was no evidence of pancreatic lesion. The endoscopic ultrasound guided fine needle aspiration showed adenocarcinoma with squamous component. After surgical resection the final diagnosis was adenosquamous pancreatic carcinoma (ASPC) arising in an intraductal papillar mucinous neoplasm (IPMN)...
September 15, 2017: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/28816351/recent-advances-in-genomic-profiling-of-adenosquamous-carcinoma-of-the-pancreas
#2
Rebecca Marcus, Anirban Maitra, Jason Roszik
Adenosquamous carcinoma of the pancreas (ASCP) is a mixed tumor type which contains squamous cell carcinoma and also ductal adenocarcinoma components. Due to the rarity of this malignancy, only very limited genomic profiling has been performed. A recent paper by Fang et al. published in The Journal of Pathology contributed to our knowledge of genomic alterations by performing whole-genome and -exome sequencing of 17 ASCP tumors. They found major genomic similarities to pancreatic ductal adenocarcinoma; however, the p53 pathway was altered in a greater proportion of cases, while a high frequency of 3p loss was a distinct copy number alteration pattern observed in ASCP...
August 17, 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28722109/genomic-signatures-of-pancreatic-adenosquamous-carcinoma-pasc
#3
Yuan Fang, Zhe Su, Jing Xie, Ruidong Xue, Qi Ma, Yanmeng Li, Yifan Zhao, Zeshi Song, Xiongxiong Lu, Hongwei Li, Chenghong Peng, Fan Bai, Baiyong Shen
In pancreatic cancer, pancreatic adenosquamous carcinoma (PASC) containing both ductal adenocarcinoma and squamous carcinoma in the same tumour represents ∼4% of the total incidence. To date, the genomic features of this mixed tumour are still unknown. We analysed the genomes of 17 PASCs and 34 pancreatic ductal adenocarcinomas (PDACs), and showed that PASC carried highly enriched TP53 mutations and 3p loss as compared with PDAC. We also showed that adenomatous and squamous components of PASC harboured comparable genomic alterations, suggesting that the two cellular components develop from the same progenitor cancer cells...
October 2017: Journal of Pathology
https://www.readbyqxmd.com/read/28226357/-analysis-of-clinicopathological-characteristics-and-prognosis-on-42-patients-with-primary-gastric-adenosquamous-cell-carcinoma
#4
Bin Li, Lin Sun, Xiaona Wang, Jingyu Deng, Xuewei Ding, Xuejun Wang, Bin Ke, Li Zhang, Rupeng Zhang, Han Liang
OBJECTIVE: To investigate the clinicopathological characteristics, diagnosis, treatment and prognosis of patients with primary gastric adenosquamous cell carcinoma. METHODS: A total of 5 562 patients with gastric neoplasm were admitted in Tianjin Medical University Cancer Institute and Hospital from January 2001 to January 2011. Among them 42 patients were diagnosed as primary gastric adenosquamous cell carcinoma, accounting for 0.76% of all the patients. The clinicopathological and follow-up data of these 42 patients with primary gastric adenosquamous cell carcinoma were retrospectively analyzed, and Cox proportional hazard model was used to analyze the prognostic factors of gastric adenocarcinoma squamous cell carcinoma...
February 25, 2017: Zhonghua Wei Chang Wai Ke za Zhi, Chinese Journal of Gastrointestinal Surgery
https://www.readbyqxmd.com/read/28133317/-pancreatic-adenosquamous-carcinoma-that-developed-after-resection-of-ipma-in-the-pancreatic-tail
#5
Akinao Kaneta, Takao Tsuchiya, Takahiro Saito, Satoshi Otani, Fujio Ito, Junichi Miura
Pancreatic adenosquamous carcinoma coexisting with intraductal papillary mucinous neoplasm(IPMN)is extremely rare. We report a rare case of pancreatic adenosquamous carcinoma that developed after resection of intraductal papillary mucinous adenoma(IPMA). A 67-year-old man was suspected of having a pancreatic cystic lesion. MRCP demonstrated a cystic lesion measuring 25mm in the pancreatic tail, which had an enhanced nodule. We therefore diagnosed branch duct type IPMN of the pancreas. Although pancreatic juice cytology did not indicate malignancy, we performed laparoscope-assisted distal pancreatectomy...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28098663/adenosquamous-carcinoma-of-the-pancreas-demonstrated-on-18f-fdg-pet-ct-imaging
#6
Lei Jiang, Hongting Nie, Lei Zhu, Yan Xiu, Hongcheng Shi
A 69-year-old woman had gradually worsening abdominal discomfort over a year. A pancreatic mass was revealed by abdominal CT. The patient underwent FDG PET/CT for staging, which demonstrated the hypermetabolic pancreatic mass with multiple liver metastases. The lesion was pathologically confirmed as pancreatic adenosquamous carcinoma after biopsy.
March 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/27725467/nab-paclitaxel-gemcitabine-therapy-for-adenosquamous-carcinoma-of-the-pancreas-an-autopsy-case
#7
Kunio Kataoka, Hiroshi Matsubara, Fumihiro Urano, Shozo Okamura, Matsuyoshi Maeda
A male patient aged over 60 years presented with abdominal pain. A solid lesion measuring 7cm was detected in the pancreatic body and tail, along with periaortic lymphadenopathy. Endoscopic ultrasound-guided fine-needle aspiration suggested squamous cell carcinoma. Nab-paclitaxel+gemcitabine therapy was effective;however, tumor progression was noted after the completion of the fourth course, and the patient died from the primary cancer 7 months after the initial consultation. Autopsy led to a definitive diagnosis of adenosquamous carcinoma of the pancreas...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27721632/oral-adenosquamous-carcinoma-report-of-a-rare-entity-with-a-special-insight-on-its-histochemistry
#8
Taneeru Sravya, Guttikonda Venkateswara Rao, Manchikatla Praveen Kumar, K Sudheerkanth
Adenosquamous carcinoma (ASC) of the head and neck (H and N) is an aggressive variant of squamous cell carcinoma (SCC). They are described as SCC subtype with high infiltrative capacity and also presents with dual histomorphology, having both squamous and glandular cell components. ASC of the H and N region is considered as a controversial tumor, as it is similar to salivary gland mucoepidermoid carcinoma. It has been described in a variety of body sites, including uterine cervix, lung and pancreas. ASC rarely develops in the upper aerodigestive tract, particularly in the oral cavity...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27295533/tracking-the-clonal-evolution-of-adenosquamous-carcinoma-a-rare-variant-of-intraductal-papillary-mucinous-neoplasm-of-the-pancreas
#9
Suguru Matsuzaka, Hidenori Karasaki, Yusuke Ono, Munehiko Ogata, Kensuke Oikawa, Susumu Tamakawa, Shin-Ichi Chiba, Miho Muraki, Tomoki Yokochi, Hiroshi Funakoshi, Toru Kono, Kazuo Nagashima, Yusuke Mizukami
Adenosquamous carcinoma (ASC) is an uncommon variant of pancreatic neoplasm. We sought to trace the mode of tumor progression using specimens of ASC associated with intraductal papillary mucinous neoplasm (IPMN) of the pancreas. A resected specimen of the primary pancreatic ASC, developed in a 72-year-old man, was subjected to mutation profiling using amplicon-targeted sequencing and digital polymerase chain reaction. DNA was isolated from each histological compartment including noninvasive IPMN, squamous cell carcinoma (SCC), and adenocarcinoma (AC)...
July 2016: Pancreas
https://www.readbyqxmd.com/read/27039322/adenosquamous-carcinoma-of-pancreas-ct-and-mr-imaging-features-in-eight-patients-with-pathologic-correlations-and-comparison-with-adenocarcinoma-of-pancreas
#10
COMPARATIVE STUDY
Fumihito Toshima, Dai Inoue, Kotaro Yoshida, Norihide Yoneda, Tetsuya Minami, Satoshi Kobayashi, Hiroko Ikdeda, Osamu Matsui, Toshifumi Gabata
PURPOSE: To reveal the CT and MR imaging features of adenosquamous carcinoma of pancreas (ASqC) in eight patients. METHODS: This study was approved by our institutional review board. Eight patients with ASqC were included in this study. Radiologic and pathologic findings were reviewed in each lesion. Additionally, radiologic imaging findings were compared between ASqC and controlled adenocarcinoma groups. RESULTS: Significant differences between ASqC and adenocarcinoma groups were noted in lesion shape, enhancement pattern on dynamic CT images, the presence or absence of necrosis, and tumor thrombus in the portal vein (PV) system...
March 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/26963139/irisin-immunohistochemistry-in-gastrointestinal-system-cancers
#11
S Aydin, T Kuloglu, M R Ozercan, S Albayrak, S Aydin, U Bakal, M Yilmaz, M Kalayci, M Yardim, M Sarac, A Kazez, H Kocdor, B Kanat, İ H Ozercan, M Gonen, M Bilgen, F Balgetir
Cancer is the leading cause of morbidity and mortality worldwide. Some studies have shown that high heat kills cancer cells. Irisin is a protein involved in heat production by converting white into brown adipose tissue, but there is no information about how its expression changes in cancerous tissues. We used irisin antibody immunohistochemistry to investigate changes in irisin expression in gastrointestinal cancers compared to normal tissues. Irisin was found in human brain neuroglial cells, esophageal epithelial cells, esophageal epidermoid carcinoma, esophageal adenocarcinoma and neuroendocrine esophageal carcinoma, gastric glands, gastric adenosquamous carcinoma, gastric neuroendocrine carcinoma, gastric signet ring cell carcinoma, neutrophils in vascular tissues, intestinal glands of colon, colon adenocarcinoma, mucinous colon adenocarcinoma, hepatocytes, hepatocellular carcinoma, islets of Langerhans, exocrine pancreas, acinar cells and interlobular and interlobular ducts of normal pancreas, pancreatic ductal adenocarcinoma, and intra- and interlobular ducts of cancerous pancreatic tissue...
2016: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/26687069/intraductal-papillary-mucinous-neoplasms-of-the-pancreas-with-concurrent-pancreatic-and-periampullary-neoplasms
#12
K Sahora, S Crippa, G Zamboni, C Ferrone, A L Warshaw, K Lillemoe, M Mino-Kenudson, M Falconi, C Fernandez-del Castillo
BACKGROUND: Intraductal papillary mucinous neoplasms (IPMN) have been reported to be associated with concurrent, distinct pancreatic ductal adenocarcinoma (con-PDAC) in about 8% (range, 4-10%) of resected branch duct (BD) lesions. In addition, other pancreatic and ampullary tumors are occasionally diagnosed with IPMN in patients undergoing pancreatic surgery. The objective of this study is to describe the prevalence, clinicopathologic characteristics and prognosis of IPMN with concurrent pancreatic and ampullary neoplasms, especially con-PDAC...
February 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26380056/adenosquamous-carcinoma-of-the-pancreas-molecular-characterization-of-23-patients-along-with-a-literature-review
#13
REVIEW
Erkut Borazanci, Sherri Z Millis, Ron Korn, Haiyong Han, Clifford J Whatcott, Zoran Gatalica, Michael T Barrett, Derek Cridebring, Daniel D Von Hoff
Adenosquamous carcinoma of the pancreas (ASCP) is a rare entity. Like adenocarcinoma of the pancreas, overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP...
September 15, 2015: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/25983330/diagnosis-of-primary-squamous-cell-carcinoma-of-the-pancreas-using-endoscopic-ultrasound-guided-core-needle-biopsy
#14
Amir Kashani, Melissa Kahn, Laith H Jamil
Primary squamous cell carcinoma (SCC) of the pancreas is a particularly rare entity. Diagnosis of this tumor is tentatively made after ruling out metastatic SCC from another primary site and adenosquamous carcinoma (ASC) of the pancreas. Here we discuss the case of a 76-year-old woman who was found to have a solitary pancreatic lesion and multiple hepatic lesions. Results of computed tomography-guided biopsy of the liver lesions were consistent with a metastatic carcinoma displaying squamous differentiation; therefore, an endoscopic ultrasound (EUS)-guided core-needle biopsy (CNB) of the pancreatic mass was performed...
May 16, 2015: Gastroenterology Report
https://www.readbyqxmd.com/read/25857130/-adenosquamous-cell-carcinoma-of-the-pancreas
#15
Masahiro Ito, Yukio Asano, Akihiko Horiguchi
No abstract text is available yet for this article.
March 2015: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/25830031/efficacy-of-platinum-chemotherapy-agents-in-the-adjuvant-setting-for-adenosquamous-carcinoma-of-the-pancreas
#16
Aaron T Wild, Avani S Dholakia, Katherine Y Fan, Rachit Kumar, Shalini Moningi, Lauren M Rosati, Daniel A Laheru, Lei Zheng, Ana De Jesus-Acosta, Susannah G Ellsworth, Amy Hacker-Prietz, Khinh R Voong, Phuoc T Tran, Ralph H Hruban, Timothy M Pawlik, Christopher L Wolfgang, Joseph M Herman
BACKGROUND: Pancreatic adenosquamous carcinoma (PASC) accounts for only 1-4% of all exocrine pancreatic cancers and carries a particularly poor prognosis. This retrospective study was performed to determine whether inclusion of a platinum agent as part of adjuvant therapy is associated with improved survival in patients with resected PASC. METHODS: Records of all patients who underwent pancreatic resection at Johns Hopkins Hospital from 1986 to 2012 were reviewed to identify those with PASC...
April 2015: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/25494951/three-synchronous-sporadic-and-separate-periampullary-and-pancreatic-tumors-more-than-a-coincidence
#17
Amit Sastry, Michael Wayne, Justin Steele, Mazen Iskandar, Songyang Yuan, Avram M Cooperman
Three sporadic, synchronous, and separate lesions in the ampulla of Vater and the head of the pancreas presented in an 81-year-old male. One was symptomatic and two were incidental. One was detected preoperatively (the ampullary lesion) and two by examination of the resected specimen (the neuroendocrine and pancreatic carcinomas). The case is summarized and the literature and the issue of commonality are reviewed.
2014: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25473201/a-huge-adenosquamous-carcinoma-of-the-pancreas-with-sarcomatoid-change-an-unusual-case-report
#18
Bao-Chun Lu, Chen Wang, Jian-Hua Yu, Zhi-Hong Shen, Jian-Hui Yang
Adenosquamous carcinoma rarely occurs in the pancreas, and is characterized by the presence of cellular components from both duct adenocarcinoma and squamous carcinoma. Here, we describe a rare case of pancreatic adenosquamous carcinoma with sarcomatous change. Immunohistochemistry showed that the sarcomatous lesion lost the epithelial marker and aberrantly expressed of acquired mesenchymal markers, which indicated that this special histological phenotype may be attributed to epithelial-mesenchymal transition...
November 21, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25410777/-a-clinical-series-of-80-patients-with-adenosquamous-carcinoma-of-pancreas
#19
Bin Song, Xiaobin Liu, Hongyun Ma, Weiping Ji, Chenghao Shao, Xiangui Hu, Gang Jin
OBJECTIVE: To raise the awareness of adenosquamous carcinoma of pancreas and discuss the treatment of it. METHODS: Clinical data of 80 cases of pancreas adenosquamous carcinoma patients in the Department of Pancreas Surgery of Changhai Hospital of Second Military Medical University from December 2003 to October 2011 were analyzed. The diagnose and treatment methods were discussed. There were 61 male cases and 19 female cases who aged from 28 to 81 years, with an average age of 60 years...
September 2014: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/24973941/clinicopathological-features-and-surgical-outcomes-of-adenosquamous-carcinoma-of-the-pancreas-a-retrospective-analysis-of-patients-with-resectable-stage-tumors
#20
COMPARATIVE STUDY
Hirotake Komatsu, Shinichi Egawa, Fuyuhiko Motoi, Takanori Morikawa, Naoaki Sakata, Takeshi Naitoh, Yu Katayose, Kazuyuki Ishida, Michiaki Unno
PURPOSE: Adenosquamous carcinoma of the pancreas is a rare subtype of pancreatic cancer. We herein describe the clinicopathological features of surgically resected cases of adenosquamous carcinoma of the pancreas. METHODS: From 2001 to 2011, 132 patients underwent R0 resection for Stage IIA or IIB pancreatic cancer. The survival rate, pathological features and recurrence status were reviewed. RESULTS: Out of 132 patients, 121 patients had tubular adenocarcinoma, and only seven had adenosquamous carcinoma (ASC)...
March 2015: Surgery Today
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