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adenosquamous pancreas

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https://www.readbyqxmd.com/read/27725467/nab-paclitaxel-gemcitabine-therapy-for-adenosquamous-carcinoma-of-the-pancreas-an-autopsy-case
#1
Kunio Kataoka, Hiroshi Matsubara, Fumihiro Urano, Shozo Okamura, Matsuyoshi Maeda
A male patient aged over 60 years presented with abdominal pain. A solid lesion measuring 7cm was detected in the pancreatic body and tail, along with periaortic lymphadenopathy. Endoscopic ultrasound-guided fine-needle aspiration suggested squamous cell carcinoma. Nab-paclitaxel+gemcitabine therapy was effective;however, tumor progression was noted after the completion of the fourth course, and the patient died from the primary cancer 7 months after the initial consultation. Autopsy led to a definitive diagnosis of adenosquamous carcinoma of the pancreas...
2016: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
https://www.readbyqxmd.com/read/27721632/oral-adenosquamous-carcinoma-report-of-a-rare-entity-with-a-special-insight-on-its-histochemistry
#2
Taneeru Sravya, Guttikonda Venkateswara Rao, Manchikatla Praveen Kumar, K Sudheerkanth
Adenosquamous carcinoma (ASC) of the head and neck (H and N) is an aggressive variant of squamous cell carcinoma (SCC). They are described as SCC subtype with high infiltrative capacity and also presents with dual histomorphology, having both squamous and glandular cell components. ASC of the H and N region is considered as a controversial tumor, as it is similar to salivary gland mucoepidermoid carcinoma. It has been described in a variety of body sites, including uterine cervix, lung and pancreas. ASC rarely develops in the upper aerodigestive tract, particularly in the oral cavity...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/27295533/tracking-the-clonal-evolution-of-adenosquamous-carcinoma-a-rare-variant-of-intraductal-papillary-mucinous-neoplasm-of-the-pancreas
#3
Suguru Matsuzaka, Hidenori Karasaki, Yusuke Ono, Munehiko Ogata, Kensuke Oikawa, Susumu Tamakawa, Shin-Ichi Chiba, Miho Muraki, Tomoki Yokochi, Hiroshi Funakoshi, Toru Kono, Kazuo Nagashima, Yusuke Mizukami
Adenosquamous carcinoma (ASC) is an uncommon variant of pancreatic neoplasm. We sought to trace the mode of tumor progression using specimens of ASC associated with intraductal papillary mucinous neoplasm (IPMN) of the pancreas. A resected specimen of the primary pancreatic ASC, developed in a 72-year-old man, was subjected to mutation profiling using amplicon-targeted sequencing and digital polymerase chain reaction. DNA was isolated from each histological compartment including noninvasive IPMN, squamous cell carcinoma (SCC), and adenocarcinoma (AC)...
July 2016: Pancreas
https://www.readbyqxmd.com/read/27039322/adenosquamous-carcinoma-of-pancreas-ct-and-mr-imaging-features-in-eight-patients-with-pathologic-correlations-and-comparison-with-adenocarcinoma-of-pancreas
#4
Fumihito Toshima, Dai Inoue, Kotaro Yoshida, Norihide Yoneda, Tetsuya Minami, Satoshi Kobayashi, Hiroko Ikdeda, Osamu Matsui, Toshifumi Gabata
PURPOSE: To reveal the CT and MR imaging features of adenosquamous carcinoma of pancreas (ASqC) in eight patients. METHODS: This study was approved by our institutional review board. Eight patients with ASqC were included in this study. Radiologic and pathologic findings were reviewed in each lesion. Additionally, radiologic imaging findings were compared between ASqC and controlled adenocarcinoma groups. RESULTS: Significant differences between ASqC and adenocarcinoma groups were noted in lesion shape, enhancement pattern on dynamic CT images, the presence or absence of necrosis, and tumor thrombus in the portal vein (PV) system...
March 2016: Abdominal Radiology
https://www.readbyqxmd.com/read/26963139/irisin-immunohistochemistry-in-gastrointestinal-system-cancers
#5
S Aydin, T Kuloglu, M R Ozercan, S Albayrak, S Aydin, U Bakal, M Yilmaz, M Kalayci, M Yardim, M Sarac, A Kazez, H Kocdor, B Kanat, İ H Ozercan, M Gonen, M Bilgen, F Balgetir
Cancer is the leading cause of morbidity and mortality worldwide. Some studies have shown that high heat kills cancer cells. Irisin is a protein involved in heat production by converting white into brown adipose tissue, but there is no information about how its expression changes in cancerous tissues. We used irisin antibody immunohistochemistry to investigate changes in irisin expression in gastrointestinal cancers compared to normal tissues. Irisin was found in human brain neuroglial cells, esophageal epithelial cells, esophageal epidermoid carcinoma, esophageal adenocarcinoma and neuroendocrine esophageal carcinoma, gastric glands, gastric adenosquamous carcinoma, gastric neuroendocrine carcinoma, gastric signet ring cell carcinoma, neutrophils in vascular tissues, intestinal glands of colon, colon adenocarcinoma, mucinous colon adenocarcinoma, hepatocytes, hepatocellular carcinoma, islets of Langerhans, exocrine pancreas, acinar cells and interlobular and interlobular ducts of normal pancreas, pancreatic ductal adenocarcinoma, and intra- and interlobular ducts of cancerous pancreatic tissue...
2016: Biotechnic & Histochemistry: Official Publication of the Biological Stain Commission
https://www.readbyqxmd.com/read/26687069/intraductal-papillary-mucinous-neoplasms-of-the-pancreas-with-concurrent-pancreatic-and-periampullary-neoplasms
#6
K Sahora, S Crippa, G Zamboni, C Ferrone, A L Warshaw, K Lillemoe, M Mino-Kenudson, M Falconi, C Fernandez-del Castillo
BACKGROUND: Intraductal papillary mucinous neoplasms (IPMN) have been reported to be associated with concurrent, distinct pancreatic ductal adenocarcinoma (con-PDAC) in about 8% (range, 4-10%) of resected branch duct (BD) lesions. In addition, other pancreatic and ampullary tumors are occasionally diagnosed with IPMN in patients undergoing pancreatic surgery. The objective of this study is to describe the prevalence, clinicopathologic characteristics and prognosis of IPMN with concurrent pancreatic and ampullary neoplasms, especially con-PDAC...
February 2016: European Journal of Surgical Oncology
https://www.readbyqxmd.com/read/26380056/adenosquamous-carcinoma-of-the-pancreas-molecular-characterization-of-23-patients-along-with-a-literature-review
#7
REVIEW
Erkut Borazanci, Sherri Z Millis, Ron Korn, Haiyong Han, Clifford J Whatcott, Zoran Gatalica, Michael T Barrett, Derek Cridebring, Daniel D Von Hoff
Adenosquamous carcinoma of the pancreas (ASCP) is a rare entity. Like adenocarcinoma of the pancreas, overall survival is poor. Characteristics of ASCP include central tumor necrosis, along with osteoclasts and hypercalcemia. Various theories exist as to why this histological subtype exists, as normal pancreas tissue has no benign squamous epithelium. Due to the rarity of this disease, limited molecular analysis has been performed, and those reports indicate unique molecular features of ASCP. In this paper, we characterize 23 patients diagnosed with ASCP through molecular profiling using immunohistochemistry staining, fluorescent in situ hybridization, chromogenic in situ hybridization, and gene sequencing, Additionally, we provide a comprehensive literature review of what is known to date of ASCP...
September 15, 2015: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/25983330/diagnosis-of-primary-squamous-cell-carcinoma-of-the-pancreas-using-endoscopic-ultrasound-guided-core-needle-biopsy
#8
Amir Kashani, Melissa Kahn, Laith H Jamil
Primary squamous cell carcinoma (SCC) of the pancreas is a particularly rare entity. Diagnosis of this tumor is tentatively made after ruling out metastatic SCC from another primary site and adenosquamous carcinoma (ASC) of the pancreas. Here we discuss the case of a 76-year-old woman who was found to have a solitary pancreatic lesion and multiple hepatic lesions. Results of computed tomography-guided biopsy of the liver lesions were consistent with a metastatic carcinoma displaying squamous differentiation; therefore, an endoscopic ultrasound (EUS)-guided core-needle biopsy (CNB) of the pancreatic mass was performed...
May 16, 2015: Gastroenterology Report
https://www.readbyqxmd.com/read/25857130/-adenosquamous-cell-carcinoma-of-the-pancreas
#9
Masahiro Ito, Yukio Asano, Akihiko Horiguchi
No abstract text is available yet for this article.
March 2015: Nihon Rinsho. Japanese Journal of Clinical Medicine
https://www.readbyqxmd.com/read/25830031/efficacy-of-platinum-chemotherapy-agents-in-the-adjuvant-setting-for-adenosquamous-carcinoma-of-the-pancreas
#10
Aaron T Wild, Avani S Dholakia, Katherine Y Fan, Rachit Kumar, Shalini Moningi, Lauren M Rosati, Daniel A Laheru, Lei Zheng, Ana De Jesus-Acosta, Susannah G Ellsworth, Amy Hacker-Prietz, Khinh R Voong, Phuoc T Tran, Ralph H Hruban, Timothy M Pawlik, Christopher L Wolfgang, Joseph M Herman
BACKGROUND: Pancreatic adenosquamous carcinoma (PASC) accounts for only 1-4% of all exocrine pancreatic cancers and carries a particularly poor prognosis. This retrospective study was performed to determine whether inclusion of a platinum agent as part of adjuvant therapy is associated with improved survival in patients with resected PASC. METHODS: Records of all patients who underwent pancreatic resection at Johns Hopkins Hospital from 1986 to 2012 were reviewed to identify those with PASC...
April 2015: Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/25494951/three-synchronous-sporadic-and-separate-periampullary-and-pancreatic-tumors-more-than-a-coincidence
#11
Amit Sastry, Michael Wayne, Justin Steele, Mazen Iskandar, Songyang Yuan, Avram M Cooperman
Three sporadic, synchronous, and separate lesions in the ampulla of Vater and the head of the pancreas presented in an 81-year-old male. One was symptomatic and two were incidental. One was detected preoperatively (the ampullary lesion) and two by examination of the resected specimen (the neuroendocrine and pancreatic carcinomas). The case is summarized and the literature and the issue of commonality are reviewed.
2014: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/25473201/a-huge-adenosquamous-carcinoma-of-the-pancreas-with-sarcomatoid-change-an-unusual-case-report
#12
Bao-Chun Lu, Chen Wang, Jian-Hua Yu, Zhi-Hong Shen, Jian-Hui Yang
Adenosquamous carcinoma rarely occurs in the pancreas, and is characterized by the presence of cellular components from both duct adenocarcinoma and squamous carcinoma. Here, we describe a rare case of pancreatic adenosquamous carcinoma with sarcomatous change. Immunohistochemistry showed that the sarcomatous lesion lost the epithelial marker and aberrantly expressed of acquired mesenchymal markers, which indicated that this special histological phenotype may be attributed to epithelial-mesenchymal transition...
November 21, 2014: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/25410777/-a-clinical-series-of-80-patients-with-adenosquamous-carcinoma-of-pancreas
#13
Bin Song, Xiaobin Liu, Hongyun Ma, Weiping Ji, Chenghao Shao, Xiangui Hu, Gang Jin
OBJECTIVE: To raise the awareness of adenosquamous carcinoma of pancreas and discuss the treatment of it. METHODS: Clinical data of 80 cases of pancreas adenosquamous carcinoma patients in the Department of Pancreas Surgery of Changhai Hospital of Second Military Medical University from December 2003 to October 2011 were analyzed. The diagnose and treatment methods were discussed. There were 61 male cases and 19 female cases who aged from 28 to 81 years, with an average age of 60 years...
September 2014: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/24973941/clinicopathological-features-and-surgical-outcomes-of-adenosquamous-carcinoma-of-the-pancreas-a-retrospective-analysis-of-patients-with-resectable-stage-tumors
#14
COMPARATIVE STUDY
Hirotake Komatsu, Shinichi Egawa, Fuyuhiko Motoi, Takanori Morikawa, Naoaki Sakata, Takeshi Naitoh, Yu Katayose, Kazuyuki Ishida, Michiaki Unno
PURPOSE: Adenosquamous carcinoma of the pancreas is a rare subtype of pancreatic cancer. We herein describe the clinicopathological features of surgically resected cases of adenosquamous carcinoma of the pancreas. METHODS: From 2001 to 2011, 132 patients underwent R0 resection for Stage IIA or IIB pancreatic cancer. The survival rate, pathological features and recurrence status were reviewed. RESULTS: Out of 132 patients, 121 patients had tubular adenocarcinoma, and only seven had adenosquamous carcinoma (ASC)...
March 2015: Surgery Today
https://www.readbyqxmd.com/read/24896656/an-expanded-training-program-for-endosonographers-improved-self-diagnosed-accuracy-of-endoscopic-ultrasound-guided-fine-needle-aspiration-cytology-of-the-pancreas
#15
Ryo Harada, Hironari Kato, Soichiro Fushimi, Masaya Iwamuro, Hirofumi Inoue, Shinichiro Muro, Ichiro Sakakihara, Yasuhiro Noma, Naoki Yamamoto, Shigeru Horiguchi, Koichiro Tsutsumi, Hiroyuki Okada, Kazuhide Yamamoto
OBJECTIVE: Rapid on-site evaluation (ROSE) of cytologic adequacy improves the diagnostic yield of endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). However, on-site advice from a cytotechnologist or cytopathologist is not always available during EUS-FNA. To enhance endosonographers' ability to assess the adequacy of EUS-FNA specimens, we designed an intensive, 2-h interactive training program. The aim of this study was to determine the usefulness of the program. METHODS: Four cytological pictures were selected by a trained cytotechnologist and board-certified cytopathologist from each of the seven patients who underwent EUS-FNA for pancreatic mass in Okayama University Hospital...
September 2014: Scandinavian Journal of Gastroenterology
https://www.readbyqxmd.com/read/24854619/ring-enhancement-pattern-on-contrast-enhanced-ct-predicts-adenosquamous-carcinoma-of-the-pancreas-a-matched-case-control-study
#16
Hiroshi Imaoka, Yasuhiro Shimizu, Nobumasa Mizuno, Kazuo Hara, Susumu Hijioka, Masahiro Tajika, Tsutomu Tanaka, Makoto Ishihara, Takeshi Ogura, Tomohiko Obayashi, Akihide Shinagawa, Masafumi Sakaguchi, Hidekazu Yamaura, Mina Kato, Yasumasa Niwa, Kenji Yamao
OBJECTIVES: Adenosquamous carcinoma of the pancreas (ASC) is a rare malignant neoplasm of the pancreas, exhibiting both glandular and squamous differentiation. However, little is known about its imaging features. This study examined the imaging features of pancreatic ASC. METHODS: We evaluated images of contrast-enhanced computed tomography (CT) and endoscopic ultrasonography (EUS). As controls, solid pancreatic neoplasms matched in a 2:1 ratio to ASC cases for age, sex and tumor location were also evaluated...
May 2014: Pancreatology: Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]
https://www.readbyqxmd.com/read/24618440/platinum-based-therapy-in-adenosquamous-pancreatic-cancer-experience-at-two-institutions
#17
Andre Luiz De Souza, Muhammad Wasif Saif
Adenosquamous carcinoma of the pancreas is a rare type of pancreatic cancer. Although its molecular biology profile has been shown to be similar to pancreatic ductal adenocarcinoma tumors, it has different prognostic features. There is no consensus or guidelines to treat this tumor differently from pancreatic adenocarcinoma, but therapies based on gemcitabine and platinum chemotherapeutics such as cisplatin and oxaliplatin have been used based on results of a few case reports. We discuss the Abstract #269 from the 2014 ASCO Gastrointestinal Cancers Symposium showing better outcomes from platinum-based therapy in this type of tumors...
March 2014: JOP: Journal of the Pancreas
https://www.readbyqxmd.com/read/24531182/contrast-enhanced-ultrasonograpic-studies-on-pancreatic-carcinoma-with-special-reference-to-staining-and-muscular-arterial-vessels
#18
COMPARATIVE STUDY
Hideya Suga, Yoshinobu Okabe, Osamu Tsuruta, Yoshiki Naito, Hisafumi Kinoshita, Atsushi Toyonaga, Naofumi Ono, Kazuhiko Oho, Masamichi Kojiro, Michio Sata
Comparative study of contrast-enhanced ultrasonography (CE-US) and histopathology of surgically resected specimens in 13 patients with pancreatic carcinoma. A time intensity curve was used to determine the percentage brightness increase in cancerous and normal regions and the patients were divided into two groups, hyperperfusion, with a percentage brightness increase over 80% (n=6) and hypoperfusion, with an increase of less than 80% (n=7) on CE-US. The hyperperfusion group included well-differentiated tubular adenocarcinoma, adenosquamous cell carcinoma and acinar cell carcinoma, while all 7 patients in the hypoperfusion group had moderately differentiated tubular adenocarcinoma...
2014: Kurume Medical Journal
https://www.readbyqxmd.com/read/24518509/clinical-characteristics-of-adenosquamous-carcinoma-of-the-pancreas-a-matched-case-control-study
#19
Hiroshi Imaoka, Yasuhiro Shimizu, Nobumasa Mizuno, Kazuo Hara, Susumu Hijioka, Masahiro Tajika, Shinya Kondo, Tsutomu Tanaka, Takeshi Ogura, Tomohiko Obayashi, Toshiyuki Hasegawa, Yasumasa Niwa, Kenji Yamao
OBJECTIVES: Adenosquamous carcinoma of the pancreas (ASC) is a variant of pancreatic ductal adenocarcinoma (PDAC), but the prognosis remains unclear. The purpose of this study was to clarify the prognosis of ASC using a matched case-control design. METHODS: We evaluated clinical characteristics of ASC treated between 2001 and 2011 in our institution. As controls, PDAC cases matched with ASC cases for sex, age, pretreatment Eastern Cooperative Oncology Group performance status, location, initial therapy and American Joint Committee on Cancer TNM staging for pancreatic cancer were also evaluated...
March 2014: Pancreas
https://www.readbyqxmd.com/read/24367734/mucoepidermoid-carcinoma-of-the-intrapancreatic-common-bile-duct-immunohistochemical-profile-prognosis-and-review-of-the-literature
#20
Adrienne E Moul, Pablo A Bejarano, Javier Casillas, Joe U Levi, Monica T Garcia-Buitrago
Mucoepidermoid carcinoma of the bile duct is a rare entity. Only one mucoepidermoid carcinoma from the common bile duct has been reported in the Korean literature. Herein, we present the first in the English literature. The tumor arose in the intrapancreatic (distal) common bile duct in an 83-year-old woman who presented with obstructive jaundice and elevated liver enzymes. The tumor invaded the underlying pancreas and peripancreatic adipose tissue and showed pagetoid spread into the extrapancreatic common bile duct and cystic duct...
2013: Case Reports in Pathology
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