Read by QxMD icon Read

Insulin adjustment application health

S Aslibekyan, A N Do, H Xu, S Li, M R Irvin, D Zhi, H K Tiwari, D M Absher, A R Shuldiner, T Zhang, W Chen, K Tanner, C Hong, B D Mitchell, G Berenson, D K Arnett
BACKGROUND AND AIMS: Adiponectin, an adipose-secreted protein that has been linked to insulin sensitivity, plasma lipids, and inflammatory patterns, is an established biomarker for metabolic health. Despite clinical relevance and high heritability, the determinants of plasma adiponectin levels remain poorly understood. METHODS AND RESULTS: We conducted the first epigenome-wide cross-sectional study of adiponectin levels using methylation data on 368,051 cytosine-phosphate-guanine (CpG) sites in CD4+ T-cells from the Genetics of Lipid Lowering Drugs and Diet Network (GOLDN, n = 991)...
March 2017: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
Jonas Gordilho Souza, Daniel Apolinario, José Marcelo Farfel, Omar Jaluul, Regina Miksian Magaldi, Alexandre Leopold Busse, Flávia Campora, Wilson Jacob-Filho
Objective: To translate, adapt and evaluate the properties of a Brazilian Portuguese version of the Spoken Knowledge in Low Literacy Patients with Diabetes, which is a questionnaire that evaluate diabetes knowledge. Methods: A cross-sectional study with type 2 diabetes patients aged ≥60 years, seen at a public healthcare organization in the city of Sao Paulo (SP). After the development of the Portuguese version, we evaluated the psychometrics properties and the association with sociodemographic and clinical variables...
October 2016: Einstein
Krystel El Hage, Vijay Pandyarajan, Nelson B Phillips, Brian J Smith, John G Menting, Jonathan Whittaker, Michael C Lawrence, Markus Meuwly, Michael A Weiss
Insulin, a protein critical for metabolic homeostasis, provides a classical model for protein design with application to human health. Recent efforts to improve its pharmaceutical formulation demonstrated that iodination of a conserved tyrosine (Tyr(B26)) enhances key properties of a rapid-acting clinical analog. Moreover, the broad utility of halogens in medicinal chemistry has motivated the use of hybrid quantum- and molecular-mechanical methods to study proteins. Here, we (i) undertook quantitative atomistic simulations of 3-[iodo-Tyr(B26)]insulin to predict its structural features, and (ii) tested these predictions by X-ray crystallography...
December 30, 2016: Journal of Biological Chemistry
Brigid A Knight, H David McIntyre, Ingrid J Hickman, Marina Noud
BACKGROUND: Modern flexible multiple daily injection (MDI) therapy requires people with diabetes to manage complex mathematical calculations to determine insulin doses on a day to day basis. Automated bolus calculators assist with these calculations, add additional functionality to protect against hypoglycaemia and enhance the record keeping process, however uptake and use depends on the devices meeting the needs of the user. We aimed to obtain user feedback on the usability of a mobile phone bolus calculator application in adults with T1DM to inform future development of mobile phone diabetes support applications...
September 15, 2016: BMC Medical Informatics and Decision Making
David C Aron
RATIONALE, AIMS AND OBJECTIVES: The purpose of medical education is to produce competent and capable professional practitioners who can combine the art and science of medicine. Moreover, this process must prepare individuals to practise in a field in which knowledge is increasing and the contexts in which that knowledge is applied are changing in unpredictable ways. The 'basic sciences' are important in the training of a physician. The goal of basic science training is to learn it in a way that the material can be applied in practice...
March 8, 2016: Journal of Evaluation in Clinical Practice
Anastasia Albanese-O'Neill, Desmond A Schatz, Jay M Bernhardt, Jennifer H Elder
PURPOSE: The purpose of this study was to identify the educational needs and technological preferences of fathers of youth aged 6 to 17 years with type 1 diabetes (T1DM). METHODS: Participants completed 2 surveys and 1 in-person semistructured interview. Survey data were collected via Qualtrics; interviews were recorded and transcribed. The quantitative data were analyzed with SPSS 22. RESULTS: Thirty fathers/stepfathers of youth 6 to 17 years old with T1DM participated in the study...
April 2016: Diabetes Educator
Pernilla Huetson, James L Palmer, Andrée Levorsen, Marie Fournier, Maeva Germe, Euan McLeod
BACKGROUND: Lixisenatide is a potent, selective and short-acting once daily prandial glucagon-like peptide-1 receptor agonist which lowers glycohemoglobin and body weight by clinically significant amounts in patients with type 2 diabetes treated with basal insulin, with limited risk of hypoglycemia. OBJECTIVE: To assess the cost-effectiveness of lixisenatide versus bolus insulin, both in combination with basal insulin, in patients with type 2 diabetes in Norway...
2015: Journal of Medical Economics
Cleliani de Cassia da Silva, Mariana Porto Zambon, Ana Carolina J Vasques, Ana Maria de B Rodrigues, Daniella Fernandes Camilo, Maria Ângela R de G M Antonio, Roberta Soares L Cassani, Bruno Geloneze
OBJECTIVE: To evaluate the correlation between neck circumference and insulin resistance and components of metabolic syndrome in adolescents with different adiposity levels and pubertal stages, as well as to determine the usefulness of neck circumference to predict insulin resistance in adolescents. METHODS: Cross-sectional study with 388 adolescents of both genders from ten to 19 years old. The adolescents underwent anthropometric and body composition assessment, including neck and waist circumferences, and biochemical evaluation...
June 2014: Revista Paulista de Pediatria: Orgão Oficial da Sociedade de Pediatria de São Paulo
Hua Heng McVin Cheen, Seng Han Lim, Ming Chien Huang, Yong Mong Bee, Hwee Lin Wee
BACKGROUND: The real-world clinical effectiveness of exogenous insulin is limited by nonadherence. Various insulin delivery systems have been developed to help improve adherence, with prefilled pens gaining popularity among adult Singaporeans with diabetes. However, adherence to insulin in people with diabetes in Singapore and most of Asia has not been studied. OBJECTIVES: This study aimed to compare adherence to premixed insulin formulated in a prefilled pen versus a vial/syringe and to identify predictors of adherence in 955 patients managed at the outpatient clinics of the largest acute care hospital in Singapore...
July 1, 2014: Clinical Therapeutics
Natalie Whitelaw, Siladitya Bhattacharya, Gwen Hoad, Graham W Horgan, Mark Hamilton, Paul Haggarty
STUDY QUESTION: Is DNA methylation in buccal cell DNA from children born following IVF (in vitro fertilization) and ICSI (intra-cytoplasmic sperm injection) different from that of spontaneously conceived children? SUMMARY ANSWER: DNA methylation in the imprinted gene, small nuclear ribonucleoprotein polypeptide N (SNRPN), was higher in children conceived by ICSI and in those born to women with the longest duration of infertility regardless of the method of conception...
July 2014: Human Reproduction
Romain Neugebauer, Julie A Schmittdiel, Mark J van der Laan
In comparative effectiveness research (CER), often the aim is to contrast survival outcomes between exposure groups defined by time-varying interventions. With observational data, standard regression analyses (e.g., Cox modeling) cannot account for time-dependent confounders on causal pathways between exposures and outcome nor for time-dependent selection bias that may arise from informative right censoring. Inverse probability weighting (IPW) estimation to fit marginal structural models (MSMs) has commonly been applied to properly adjust for these expected sources of bias in real-world observational studies...
June 30, 2014: Statistics in Medicine
Kyra M Garofolo, Sharon D Yeatts, Viswanathan Ramakrishnan, Edward C Jauch, Karen C Johnston, Valerie L Durkalski
BACKGROUND: Traditionally in acute stroke clinical trials, the primary clinical outcome employed is a dichotomized modified Rankin Scale (mRS). New statistical methods, such as responder analysis, are being used in stroke studies to address the concern that baseline prognostic variables, such as stroke severity, impact the likelihood of a successful outcome. Responder analysis allows the definition of success to vary according to baseline prognostic variables, producing a more clinically relevant insight into the actual effect of investigational treatments...
April 11, 2013: Trials
Kamran M A Aziz
Ramadan fasting is an obligatory duty for Muslims. Unique physiologic and metabolic changes occur during fasting which requires adjustments of diabetes medications. Although challenging, successful fasting can be accomplished if pre-Ramadan extensive education is provided to the patients. Current research was conducted to study effective Ramadan fasting with different OHAs/insulins without significant risk of hypoglycemia in terms of HbA1c reductions after Ramadan. ANOVA model was used to assess HbA1c levels among different education statuses...
September 2013: Recent Patents on Endocrine, Metabolic & Immune Drug Discovery
Kathy K Hager, Paul Loprinzi, Dennis Stone
OBJECTIVE: The objectives of this article are to (1) describe the outcomes of a diabetes care program in a long term care facility dedicated to diabetes excellence and (2) compare the relevant outcome variables of research published between 2007 and 2012 with the results found in the studied facility. DESIGN: Three-year retrospective chart review of the facility's residents with comparison to extant literature. PARTICIPANTS: A total of 224 resident charts within the studied facility were reviewed...
November 2013: Journal of the American Medical Directors Association
Emmanouil G Spanakis, Franco Chiarugi, Angelina Kouroubali, Stephan Spat, Peter Beck, Stefan Asanin, Peter Rosengren, Tamas Gergely, Jesper Thestrup
BACKGROUND: Diabetes, a metabolic disorder, has reached epidemic proportions in developed countries. The disease has two main forms: type 1 and type 2. Disease management entails administration of insulin in combination with careful blood glucose monitoring (type 1) or involves the adjustment of diet and exercise level, the use of oral anti-diabetic drugs, and insulin administration to control blood sugar (type 2). OBJECTIVE: State-of-the-art technologies have the potential to assist healthcare professionals, patients, and informal carers to better manage diabetes insulin therapy, help patients understand their disease, support self-management, and provide a safe environment by monitoring adverse and potentially life-threatening situations with appropriate crisis management...
2012: Interactive Journal of Medical Research
Elissa R Weitzman, Skyler Kelemen, Kenneth D Mandl
OBJECTIVE: Test a novel health monitoring approach by engaging an international online diabetes social network (SN) in consented health surveillance. METHODS: Collection of structured self-reports about preventive and self-care practices and health status using a software application ("app") that supports SN-mediated health research. Comparison of SN measures by diabetes type; and, SN with Behavioral Risk Factor Surveillance System (BRFSS) data, for US-residing insulin dependent respondents, using logistic regression...
2011: Online Journal of Public Health Informatics
Ayo P Doumatey, Amy R Bentley, Jie Zhou, Hanxia Huang, Adebowale Adeyemo, Charles N Rotimi
BACKGROUND: It has been suggested that adiponectin may offer protection against the adverse health effects of obesity. In this study, we determined the prevalence of paradoxically high adiponectin or paradoxical hyperadiponectinemia (PHA) among obese African Americans and investigated its relationship with the metabolically healthy obese (MHO) phenotype. METHODS: Total adiponectin and metabolic markers including fasting glucose, insulin, serum lipids and obesity measures were determined in 822 unrelated participants from the Howard University Family Study (HUFS)...
April 1, 2012: Journal of Endocrinology and Metabolism
O Yaw Addo, Mark A Pereira, John H Himes
OBJECTIVE: We compared adiposity from triceps and subscapular skinfold thickness (SF) with total body fat from dual energy X-ray absorptiometry (DXA) in their associations with HOMA insulin resistance for a large sample of US adolescents. METHODS: We analyzed cross-sectional data from 1496 adolescents, ages 12.0-17.99 year examined as part of the US national health and nutrition examination survey (NHANES) cycles 2001-04. Data collected included skinfold thicknesses, DXA-based total body fat (DXF), serum insulin and fasting glucose for homeostasis model assessment of insulin resistance (HOMA-IR)...
November 2012: American Journal of Human Biology: the Official Journal of the Human Biology Council
A Dulloo
A population shift towards obesity is a major side-effect of changes in lifestyle that accompany economic prosperity, and a high risk factor for many chronic degenerative diseases including non-insulin-dependent diabetes mellitus (NIDDM), coronary heart disease and hypertension. According to current WHO population statistics, 40% of obese patients eventually develop NIDDM, 80% of individuals with NIDDM are obese and the incidence of hypertension in obesity and NIDDM could be as high as 50%. Of particular concern for developing countries is the strong epidemiological evidence indicating that the prevalence of obesity and diabetes often increase in epidemic proportions in communities emerging from lifestyles of subsistence into affluence...
March 1996: Malaysian Journal of Nutrition
Z M Ferraro, Q Qiu, A Gruslin, K B Adamo
STUDY QUESTION: Does maternal obesity affect insulin-like growth factor (IGF) axis protein expression patterns in maternal and cord blood? SUMMARY ANSWER: Maternal obesity attenuates cord blood expression of IGF-binding protein (IGFBP)-4. WHAT IS KNOWN AND WHAT THIS PAPER ADDS: The IGF axis plays a critical role in fetal growth and development. Maternal obesity compromises IGF axis protein expression in fetal circulation, which is consistent with the findings of epidemiological studies suggesting that maternal obesity has an independent effect on fetal growth signals during in utero development...
August 2012: Human Reproduction
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"