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Insulin adjustment

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https://www.readbyqxmd.com/read/28743060/glucose-fluctuation-and-the-resultant-endothelial-injury-are-correlated-with-pancreatic-%C3%AE-cell-dysfunction-in-patients-with-coronary-artery-disease
#1
Makoto Murata, Hitoshi Adachi, Shigeru Oshima, Masahiko Kurabayashi
AIMS: We evaluated whether glucose fluctuation (GF) causes vascular endothelial injury and affects glucometabolic factors during lengthy oral glucose tolerance test (OGTT). METHODS: We enrolled consecutive 116 patients with coronary artery disease (CAD) who were performed coronary angiography and 4-h OGTT. Blood samples were collected before and 4h after glucose load to measure endothelial injury factor [von Willebrand factor (vWF) and vWF/a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs 13 (ADAMTS-13) ratio]...
July 8, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28741239/type-2-diabetes-mellitus-and-simple-glucose-metabolism-parameters-may-reliably-predict-nonalcoholic-fatty-liver-disease-features
#2
Everton Cazzo, Laísa Simakawa Jimenez, Martinho Antonio Gestic, Murillo Pimentel Utrini, Fábio Henrique Mendonça Chaim, Felipe David Mendonça Chaim, José Carlos Pareja, Elinton Adami Chaim
OBJECTIVE: This study aims to investigate the correlation between features of NAFLD among individuals with morbid obesity and the surrogate IR markers homeostasis model assessment (HOMA), product of triglycerides and glucose (TyG), and triglyceride-to-high-density-lipoprotein ratio (TG/HDL-c). METHODS: A cross-sectional study, which enrolled 89 individuals who consecutively underwent bariatric surgery from February through December 2015, was conducted. NAFLD was assessed through histological examination of liver biopsies and correlated with the values of HOMA, TyG, and TG/HDL-c and their respective cutoff points for insulin resistance (IR)...
July 24, 2017: Obesity Surgery
https://www.readbyqxmd.com/read/28741071/a-multicenter-observational-study-of-lanreotide-depot-autogel-lan-in-patients-with-acromegaly-in-the-united-states-2-year-experience-from-the-soda-registry
#3
Roberto Salvatori, Murray B Gordon, Whitney W Woodmansee, Adriana G Ioachimescu, Don W Carver, Beloo Mirakhur, David Cox, Mark E Molitch
PURPOSE: This analysis evaluates the 2-year effectiveness and safety of lanreotide depot/autogel (LAN), as well as treatment convenience and acromegaly symptom relief, from the Somatuline(®) Depot for Acromegaly (SODA) registry, a post-marketing, open-label, observational, multicenter, United States registry study. METHODS: Patients with acromegaly treated with LAN were eligible for enrollment. Demographics, LAN dose, extended dosing interval (EDI) (interval of injections ≥42 days), insulin-like growth factor 1 (IGF-1), growth hormone (GH), glycated hemoglobin, adverse events (AEs), injection convenience, and symptom data were collected...
July 24, 2017: Pituitary
https://www.readbyqxmd.com/read/28739297/the-impact-of-insulin-dependence-on-short-term-postoperative-complications-in-diabetic-patients-undergoing-total-shoulder-arthroplasty
#4
Michael C Fu, Venkat Boddapati, David M Dines, Russell F Warren, Joshua S Dines, Lawrence V Gulotta
BACKGROUND: The number of total shoulder arthroplasty (TSA) procedures performed is steadily increasing, and it is important to characterize predictors of postoperative complications for risk assessment models. Whereas diabetes has been associated with increased morbidity after TSA, the impact of insulin dependence on the risk profile of diabetic patients has not been described. METHODS: The National Surgical Quality Improvement Program database from 2011-2014 was used to identify 5918 TSA cases...
July 21, 2017: Journal of Shoulder and Elbow Surgery
https://www.readbyqxmd.com/read/28739267/h-pylori-seroprevalence-and-risk-of-diabetes-an-ancillary-case-control-study-nested-in-the-diabetes-prevention-program
#5
Saud Alzahrani, Jason Nelson, Steven F Moss, Jessica K Paulus, William C Knowler, Anastassios G Pittas
OBJECTIVE: To determine the association between H. pylori infection and risk of incident diabetes in adults at high risk for diabetes who participated in the Diabetes Prevention Program (DPP) study. METHODS: In a nested case-control study conducted among 421 adults with newly diagnosed diabetes and 421 matched controls, we examined the association between serological status of H. pylori at baseline and risk of incident diabetes over a mean follow-up period of 2...
June 3, 2017: Journal of Diabetes and its Complications
https://www.readbyqxmd.com/read/28737991/lowering-cost-share-may-improve-rates-of-home-glucose-monitoring-among-patients-with-diabetes-using-insulin
#6
Yiqiong Xie, Abiy Agiro, Kevin Bowman, Andrea DeVries
BACKGROUND: Not much is known about the extent to which lower cost share for blood glucose strips is associated with persistent filling. OBJECTIVE: To evaluate the relationship between cost sharing for blood glucose testing strips and continued use of testing strips. METHODS: This is a retrospective observational study using medical and pharmacy claims data integrated with laboratory hemoglobin A1c (A1c) values for patients using insulin and blood glucose testing strips...
August 2017: Journal of Managed Care & Specialty Pharmacy
https://www.readbyqxmd.com/read/28736442/family-history-of-type-2-diabetes-abdominal-adipocyte-size-and-markers-of-the-metabolic-syndrome
#7
P Anthanont, P Ramos, M D Jensen, K C Hames
BACKGROUND/OBJECTIVES: A major risk factor of type 2 diabetes mellitus (T2DM) is a positive family history of diabetes. First degree relatives (FDR) of patients with T2DM are more insulin resistant and are reported to have larger abdominal subcutaneous adipocytes than adults without a family history. Our objectives were to assess whether a family history of T2DM is associated with larger abdominal adipocytes independent of age, sex, and abdominal subcutaneous fat and to assess whether FDR of T2DM is also independently related to femoral adipocyte size, as well as visceral fat and fasting plasma triglyceride (TG) concentrations...
July 24, 2017: International Journal of Obesity: Journal of the International Association for the Study of Obesity
https://www.readbyqxmd.com/read/28735219/electrodeposition-to-construct-free-standing-chitosan-layered-double-hydroxides-hydro-membrane-for-electrically-triggered-protein-release
#8
Pengkun Zhao, Yanan Zhao, Ling Xiao, Hongbing Deng, Yumin Du, Yun Chen, Xiaowen Shi
In this study, we report the electrodeposition of a chitosan/layered double hydroxides (LDHs) hydro-membrane for protein release triggered by an electrical signal. The electrodeposition was performed in a chitosan and insulin loaded LDHs suspension in the absence of salt. A free-standing chitosan/LDHs hydro-membrane was generated on the electrode with improved mechanical properties, which is dramatically different from the weak hydrogel deposited in the presence of salt. The amount of LDHs in the hydro-membrane affects the optical transmittance and multilayered structure of the hybrid membrane...
July 13, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28734987/bioavailable-and-free-25-hydroxyvitamin-d-and-vitamin-d-binding-protein-in-polycystic-ovary-syndrome-relationships-with-obesity-and-insulin-resistance
#9
Negar Naderpoor, Soulmaz Shorakae, Sally K Abell, Aya Mousa, Anju E Joham, Lisa J Moran, Nigel K Stepto, Poli Mara Spritzer, Helena J Teede, Barbora de Courten
Polycystic ovary syndrome (PCOS) is a common condition characterised by both reproductive and metabolic features (obesity, insulin resistance, diabetes risk). Some evidence suggests that women with PCOS have lower vitamin D levels compared to healthy controls. Vitamin D binding protein (DBP) is the main carrier of vitamin D in circulation and plays an important role in regulating vitamin D concentration and bioavailability for target tissues. To our knowledge, no previous studies have examined DBP, bioavailable and free 25-hydroxyvitamin D (25(OH)D) in women with PCOS...
July 19, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/28734090/sleep-duration-and-progression-to-diabetes-in-people-with-prediabetes-defined-by-hba1c-concentration
#10
Chan-Won Kim, Yoosoo Chang, Eunju Sung, Seungho Ryu
AIMS: To evaluate the association between sleep duration and the risk of progression to diabetes among people with prediabetes, defined by HbA1c values. METHODS: We conducted a cohort study in 17 983 adults who underwent health check-up examinations, including assessments of sleep duration and quality. Diabetes was defined as either HbA1c ≥48 mmol/mol (6.5%), or the use of antidiabetic medication. Time-dependent proportional hazards models were used to evaluate the association between sleep duration and the risk of progression to diabetes...
July 22, 2017: Diabetic Medicine: a Journal of the British Diabetic Association
https://www.readbyqxmd.com/read/28733174/lipoprotein-insulin-resistance-score-and-risk-of-incident-diabetes-during-extended-follow-up-of-20%C3%A2-years-the-women-s-health-study
#11
Paulo H N Harada, Olga V Demler, Sagar B Dugani, Akintunde O Akinkuolie, Manickavasagar V Moorthy, Paul M Ridker, Nancy R Cook, Aruna D Pradhan, Samia Mora
BACKGROUND: Type II diabetes (T2D) is preceded by prolonged insulin resistance and relative insulin deficiency incompletely captured by glucose metabolism parameters, high-density lipoprotein (HDL) cholesterol and triglycerides. OBJECTIVE: Whether lipoprotein insulin resistance (LPIR) score, a metabolomic marker, is associated with incident diabetes and improves risk reclassification over traditional markers on extended follow-up. METHODS: Among 25,925 nondiabetic women aged 45 years or older, LPIR was measured by nuclear magnetic resonance spectroscopy as a weighted score of very low density lipoprotein, low-density lipoprotein, and HDL particle sizes, and their subsets concentrations...
June 21, 2017: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/28732569/high-insulin-like-growth-factor-binding-protein-1-igfbp-1-is-associated-with-low-relative-muscle-mass-in-older-women
#12
Frej Stilling, Sara Wallenius, Karl Michaëlsson, Christine Dalgård, Kerstin Brismar, Alicja Wolk
OBJECTIVE: Skeletal muscles serve several important roles in maintaining good health. Insulin-like growth factor-1 (IGF-1) is a promoter of protein synthesis in skeletal muscle. Its binding protein, Insulin-like growth factor-binding protein-1 (IGFBP-1) can be one determinant of IGF-1 activity. In the present study we investigate the association between serum IGFBP-1 and muscle mass. DESIGN: Cross-sectional analysis of 4908 women, between 55 and 85years old, participating in the Swedish Mammography Cohort-Clinical...
August 2017: Metabolism: Clinical and Experimental
https://www.readbyqxmd.com/read/28731619/new-onset-diabetes-after-kidney-transplantation-is-associated-with-increased-mortality-a-retrospective-cohort-study
#13
L Cooper, N Oz, G Fishman, T Shohat, R Rahamimov, E Mor, H Green, A Grossman
OBJECTIVE: Clinical outcomes in individuals with new onset diabetes after transplantation (NODAT) and the optimal treatment for this complication are poorly characterized. This study was intended to better define these issues. METHODS: Patients who underwent kidney transplantation and did not have diabetes prior to transplantation were included in the study and clinical outcomes were compared between those who developed NODAT and those who did not. In those who developed NODAT, oral therapy was compared with insulin based therapy...
July 21, 2017: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28728559/effect-of-insulin-therapy-and-dietary-adjustments-on-safety-and-performance-during-simulated-soccer-tests-in-people-with-type-1-diabetes-study-protocol-for-a-randomized-controlled-trial
#14
Javier Calvo-Marín, Gabriel Torrealba-Acosta, Matthew Campbell, Jesse Gaboury, Ajmol Ali, Chih Hao Chen-Ku
BACKGROUND: Despite the reduction in glycemic derangement in patients with type 1 diabetes mellitus (T1D) through dietary and therapeutic adjustments implemented before, during and after continuous exercise, evidence for its effectiveness with intermittent forms of exercise, such as soccer, is still lacking. METHODS/DESIGN: We designed a study protocol for a randomized, crossover, double-blinded, controlled trial, for the evaluation of the effect that a strategy of dietary and therapeutic modifications may have on safety and performance of persons with T1D in soccer training sessions and cognitive testing...
July 20, 2017: Trials
https://www.readbyqxmd.com/read/28726959/association-of-cultured-myotubes-and-fasting-plasma-metabolite-profiles-with-mitochondrial-dysfunction-in-type-2-diabetes-subjects
#15
Mohamad Hafizi Abu Bakar, Mohamad Roji Sarmidi
Accumulating evidence implicates mitochondrial dysfunction-induced insulin resistance in skeletal muscle as the root cause for the greatest hallmarks of type 2 diabetes (T2D). However, the identification of specific metabolite-based markers linked to mitochondrial dysfunction in T2D has not been adequately addressed. Therefore, we sought to identify the markers-based metabolomics for mitochondrial dysfunction associated with T2D. First, a cellular disease model was established using human myotubes treated with antimycin A, an oxidative phosphorylation inhibitor...
July 20, 2017: Molecular BioSystems
https://www.readbyqxmd.com/read/28723611/parent-reported-nutritional-risk-and-laboratory-indices-of-cardiometabolic-risk-and-in-preschool-aged-children
#16
Navindra Persaud, Hedyeh Ziai, Gerald Lebovic, Jonathon L Maguire, Marina Khovratovich, Janis A Randall Simpson, Khosrow Adeli, Jill Hamilton, Brian W McCrindle, Patricia C Parkin, Catherine S Birken
BACKGROUND: Eating habits formed during childhood may contribute to the increasing prevalence of cardiometabolic disorders. Assessing nutritional risk in young children may help to prevent later cardiometabolic disease. The objective of this study was to determine whether parent-reported nutritional risk in preschool-aged children was associated with laboratory indices of cardiometabolic risk, namely leptin and insulin. METHODS: In this cross-sectional study, the relationship between nutritional risk as determined by the parent-completed NutriSTEP® questionnaire was assessed and compared to the serum leptin and insulin concentrations, hormones involved in regulation of food intake and biomarkers of adiposity and cardiometabolic risk...
July 19, 2017: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/28721709/-paradoxal-decrease-and-metabolic-effects-of-bnp-in-obese-patient
#17
Rémy C Martin-Du-Pan, Alain Golay
Natriuretic peptides (NP), ANP and BNP, are produced by cardiomyocytes when there is stretching of the ventricular and auricular walls in heart failure (HF). Their vasodilatator and natriuretic effect oppose to volume and pressure overload occurring in HF. Several studies have observed decreased levels of NP in obese and diabetic people and in patients with insulin resistance. This decrease could contribute to hypertension, frequently observed in obesity. NP have also a lipolytic action. Low levels of NP could promote obesity...
March 22, 2017: Revue Médicale Suisse
https://www.readbyqxmd.com/read/28721436/age-at-natural-menopause-and-risk-of-type-2-diabetes-a-prospective-cohort-study
#18
Taulant Muka, Eralda Asllanaj, Naim Avazverdi, Loes Jaspers, Najada Stringa, Jelena Milic, Symen Ligthart, M Arfan Ikram, Joop S E Laven, Maryam Kavousi, Abbas Dehghan, Oscar H Franco
AIMS/HYPOTHESIS: In this study, we aimed to examine the association between age at natural menopause and risk of type 2 diabetes, and to assess whether this association is independent of potential mediators. METHODS: We included 3639 postmenopausal women from the prospective, population-based Rotterdam Study. Age at natural menopause was self-reported retrospectively and was treated as a continuous variable and in categories (premature, <40 years; early, 40-44 years; normal, 45-55 years; and late menopause, >55 years [reference])...
July 18, 2017: Diabetologia
https://www.readbyqxmd.com/read/28721400/weight-adjusted-lean-body-mass-and-calf-circumference-are-protective-against-obesity-associated-insulin-resistance-and-metabolic-abnormalities
#19
Toshinari Takamura, Yuki Kita, Masatoshi Nakagen, Masaru Sakurai, Yuki Isobe, Yumie Takeshita, Kohzo Kawai, Takeshi Urabe, Shuichi Kaneko
BACKGROUND: To test the hypothesis that preserved muscle mass is protective against obesity-associated insulin resistance and metabolic abnormalities, we analyzed the relationship of lean body mass and computed tomography-assessed sectional areas of specific skeletal muscles with insulin resistance and metabolic abnormalities in a healthy cohort. METHODS: A total of 195 subjects without diabetes who had completed a medical examination were included in this study...
July 2017: Heliyon
https://www.readbyqxmd.com/read/28720696/persistent-organic-pollutants-impair-insulin-secretory-function-of-pancreatic-beta-cells-human-and-in-vitro-evidence
#20
Yu-Mi Lee, Chae-Myeong Ha, Se-A Kim, Themis Thoudam, Young-Ran Yoon, Dae-Jung Kim, Hyeon-Chang Kim, Hyo-Bang Moon, Sungmi Park, In-Kyu Lee, Duk-Hee Lee
Persistent organic pollutants (POPs), especially organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs), have emerged as a new risk factor of type 2 diabetes (T2D). We evaluated whether chronic exposure to low-dose POPs affects insulin secretory function of beta-cells in humans and in vitro cells. Serum concentrations of OCPs and PCBs were measured in 200 nondiabetic adults. Mathematical-model-based insulin secretion indices were estimated using a 2-hour 7-sample oral glucose tolerance test. Insulin secretion by INS1E beta-cells was measured after 48-hour treatment with 3 OCPs or a PCB mixture...
July 18, 2017: Diabetes
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