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intracerebral haemorrhage

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https://www.readbyqxmd.com/read/29128801/oleuropein-protects-intracerebral-hemorrhage-induced-disruption-of-blood-brain-barrier-through-alleviation-of-oxidative-stress
#1
Jing Shi, Guofeng Wu, Xiaohua Zou, Ke Jiang
BACKGROUND: Intracerebral haemorrhage (ICH) as a devastating form of stroke has remained a public health threat due to lack of FDA-approved therapy. Oxidative stress originated from blood cell degradation products plays a crucial role in the ICH pathogenesis. In this study we evaluated oleuropein, a potent natural antioxidant from olive, in a well-established rat ICH model from overall symptoms to detailed molecular mechanism. METHODS: ICH model was established by collagenase injection to the brain of rats, which were randomly divided into groups with vehicle mock treatment, followed by treatment with different doses of oleuropein via daily intraperitoneal injection post-ICH for 3days...
May 11, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29128343/post-stroke-depression-mechanisms-and-pharmacological-treatment
#2
REVIEW
Roberto Federico Villa, Federica Ferrari, Antonio Moretti
Depression, the most frequent psychiatric disorder following ischaemic stroke, negatively affects survivals' functional outcome, response to rehabilitation and quality of life. Approximately, one-third of them are affected by post-stroke depression (PSD), making it a serious social and public health problem and anti-depressant preventive and curative therapies worth investigating. However, a two-way association between depression and stroke has been also established: stroke increases the risk of PSD, but depression is an independent risk factor for stroke...
November 8, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29112977/initial-clinical-experience-with-dual-layer-detector-spectral-ct-in-patients-with-acute-intracerebral-haemorrhage-a-single-centre-pilot-study
#3
Soo Buem Cho, Hye Jin Baek, Kyeong Hwa Ryu, Jin Il Moon, Bo Hwa Choi, Sung Eun Park, Kyungsoo Bae, Kyung Nyeo Jeon, Dong Wook Kim
PURPOSE: The purpose of this study was to investigate the clinical feasibility of spectral analyses using dual-layer detector spectral computed tomography (CT) in acute intracerebral haemorrhage (ICH). MATERIAL AND METHODS: We retrospectively reviewed patients with acute ICH who underwent CT angiography on a dual-layer detector spectral CT scanner. A spectral data analysis was performed to detect contrast enhancement in or adjacent to acute ICH by using spectral image reconstructions including monoenergetic (MonoE), virtual noncontrast (VNC), and iodine overlay fusion images...
2017: PloS One
https://www.readbyqxmd.com/read/29070646/amyloid-pet-burden-and-regional-distribution-in-cerebral-amyloid-angiopathy-a-systematic-review-and-meta-analysis-of-biomarker-performance
#4
Andreas Charidimou, Karim Farid, Hsin-Hsi Tsai, Li-Kai Tsai, Rouh-Fang Yen, Jean-Claude Baron
INTRODUCTION: We performed a meta-analysis to synthesise current evidence on amyloid-positron emission tomography (PET) burden and presumed preferential occipital distribution in sporadic cerebral amyloid angiopathy (CAA). METHODS: In a PubMed systematic search, we identified case-control studies with extractable data on global and occipital-to-global amyloid-PET uptake in symptomatic patients with CAA (per Boston criteria) versus control groups (healthy participants or patients with non-CAA deep intracerebral haemorrhage) and patients with Alzheimer's disease...
October 25, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29065915/interventions-for-acute-stroke-management-in-africa-a-systematic-review-of-the-evidence
#5
Leonard Baatiema, Carina K Y Chan, Adem Sav, Shawn Somerset
BACKGROUND: The past decades have witnessed a rapid evolution of research on evidence-based acute stroke care interventions worldwide. Nonetheless, the evidence-to-practice gap in acute stroke care remains variable with slow and inconsistent uptake in low-middle income countries (LMICs). This review aims to identify and compare evidence-based acute stroke management interventions with alternative care on overall patient mortality and morbidity outcomes, functional independence, and length of hospital stay across Africa...
October 24, 2017: Systematic Reviews
https://www.readbyqxmd.com/read/29061107/non-endoscopic-minimally-invasive-evacuation-of-intracerebral-haematoma-ich-a-case-report
#6
Tomaz Velnar
Spontaneous intracerebral haemorrhage (ICH) is one of the most serious causes of stroke, leading to high rates of disability and mortality. In addition to intensive medical treatment, surgery may help to improve the prognosis in patients with ICH. A rapid reversal of coagulopathy is essential in these patients, although it may be difficult to achieve in various bleeding disorders. In such cases, when surgery is needed, a minimally invasive approach is recommended. In this case report, we described and shortly discussed the evacuation of ICH with a minimally invasive non-endoscopic surgical technique...
October 24, 2017: Bosnian Journal of Basic Medical Sciences
https://www.readbyqxmd.com/read/29054916/acute-convexity-subarachnoid-haemorrhage-and-cortical-superficial-siderosis-in-probable-cerebral-amyloid-angiopathy-without-lobar-haemorrhage
#7
Andreas Charidimou, Grégoire Boulouis, Panagiotis Fotiadis, Li Xiong, Alison M Ayres, Kristin M Schwab, Mahmut Edip Gurol, Jonathan Rosand, Steve M Greenberg, Anand Viswanathan
INTRODUCTION: Acute non-traumatic convexity subarachnoid haemorrhage (cSAH) is increasingly recognised in cerebral amyloid angiopathy (CAA). We investigated: (a) the overlap between acute cSAH and cortical superficial siderosis-a new CAA haemorrhagic imaging signature and (b) whether acute cSAH presents with particular clinical symptoms in patients with probable CAA without lobar intracerebral haemorrhage. METHODS: MRI scans of 130 consecutive patients meeting modified Boston criteria for probable CAA were analysed for cortical superficial siderosis (focal, ≤3 sulci; disseminated, ≥4 sulci), and key small vessel disease markers...
October 20, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29037015/comparison-of-spot-sign-blend-sign-and-black-hole-sign-for-outcome-prediction-in-patients-with-intracerebral-hemorrhage
#8
Peter B Sporns, Michael Schwake, André Kemmling, Jens Minnerup, Wolfram Schwindt, Thomas Niederstadt, Rene Schmidt, Uta Hanning
BACKGROUND AND PURPOSE: Blend sign (BS) and black hole sign (BHS) on non-contrast computed tomography (NCCT) and spot sign (SS) on CT-angiography (CTA) are indicators of early hematoma expansion in spontaneous intracerebral hemorrhage (ICH). However, their independent contributions to outcome have not been well explored. METHODS: In this retrospective study, inclusion criteria were: 1) spontaneous ICH and 2) NCCT and CTA performed on admission within 6 hours after onset of symptoms...
September 2017: Journal of Stroke
https://www.readbyqxmd.com/read/29030422/outcome-of-intracerebral-haemorrhage-related-to-non-vitamin-k-antagonists-oral-anticoagulants-versus-vitamin-k-antagonists-a-comprehensive-systematic-review-and-meta-analysis
#9
Gregoire Boulouis, Andrea Morotti, Marco Pasi, Joshua N Goldstein, M Edip Gurol, Andreas Charidimou
INTRODUCTION: The characteristics and natural history of acute non-vitamin K antagonists oral anticoagulants (NOAC)-associated intracerebral haemorrhage (ICH) are largely unknown. We performed a comprehensive systematic review and meta-analysis to compare baseline ICH volume, haematoma expansion and clinical outcomes between NOAC-ICH versus vitamin K antagonists-ICH (VKA-ICH). METHODS: We searched PubMed and conference abstracts for observational studies comparing baseline characteristics and outcomes in patients with NOAC-ICH versus VKA-ICH using an appropriate keyword/MeSH term search strategy...
October 13, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28988163/high-sensitivity-c-reactive-protein-as-a-predictor-of-inhospital-mortality-in-patients-with-cardiovascular-disease-at-an-emergency-department-a-retrospective-cohort-study
#10
Ryo Yoshinaga, Yasufumi Doi, Katsuhiko Ayukawa, Shizukiyo Ishikawa
OBJECTIVE: We investigated whether serum high-sensitivity C reactive protein (hs-CRP) levels measured in an emergency department (ED) are associated with inhospital mortality in patients with cardiovascular disease (CVD). DESIGN: A retrospective cohort study. SETTING: ED of a teaching hospital in Japan. PARTICIPANTS: 12 211 patients with CVD aged ≥18 years who presented to the ED by an ambulance between 1 February 2006 and 30 September 2014 were evaluated...
October 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/28987454/in-situ-hydrogels-enhancing-postoperative-functional-recovery-by-reducing-iron-overload-after-intracerebral-haemorrhage
#11
Tiantian Luo, Tingwang Guo, Qian Yang, Shilei Hao, Ju Wang, Zhongjun Cheng, Qing Qu, Ye He, Yuhua Gong, Feiyan Gao, Wenfeng Li, Haijian Xia, Bochu Wang
The role of surgery for most patients with spontaneous intracerebral haemorrhage (ICH) remains controversial due to the continuous occurrence of postoperative iron overload induced by low clot clearance rate. In this study, human hair keratose hydrogel (KG) loading with minocycline hydrochloride (MH) were prepared to reduce iron overload for the improvement of the postoperative functional recovery after ICH aspiration surgery. Hemoglobin-induced iron accumulation in rat primary neuronal culture was delayed by the adsorptive capacity of blank KG, while MH-loaded KG displayed a stronger and more thorough cytoprotective effect than blank KG due to the combined effect of absorptive action to iron and sustained release of the iron chelator...
October 5, 2017: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/28986471/international-multicentre-validation-of-the-arteriovenous-malformation-related-intracerebral-haemorrhage-avich-score
#12
Marian C Neidert, Michael T Lawton, Louis J Kim, John D Nerva, Kaoru Kurisu, Fusao Ikawa, Juergen Konczalla, Nazife Dinc, Volker Seifert, Julian Habdank-Kolaczkowski, Taketo Hatano, Makoto Hayase, Dino Podlesek, Gabriele Schackert, Thomas Wanet, Sven Gläsker, Christoph J Griessenauer, Christopher S Ogilvy, Andreas Kneist, Ulrich Sure, Burkhardt Seifert, Luca Regli, Oliver Bozinov, Jan-Karl Burkhardt
OBJECTIVE: The recently published arteriovenous malformation-related intracerebral haemorrhage (AVICH) score showed better outcome prediction for patients with arteriovenous malformation (AVM)-related intracerebral haemorrhage (ICH) than other AVM or ICH scores. Here we present the results of a multicentre, external validation of the AVICH score. METHODS: All participating centres (n=11) provided anonymous data on 325 patients to form the Spetzler-Martin (SM) grade, the supplemented SM (sSM) grade, the ICH score and the AVICH score...
October 6, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28969386/genetic-variants-influencing-elevated-myeloperoxidase-levels-increase-risk-of-stroke
#13
Chia-Ling Phuah, Tushar Dave, Rainer Malik, Miriam R Raffeld, Alison M Ayres, Joshua N Goldstein, Anand Viswanathan, Steven M Greenberg, Jeremiasz M Jagiella, Björn M Hansen, Bo Norrving, Jordi Jimenez-Conde, Jaume Roquer, Alexander Pichler, Christian Enzinger, Joan Montaner, Israel Fernandez-Cadenas, Arne Lindgren, Agnieszka Slowik, Reinhold Schmidt, Alessandro Biffi, Natalia Rost, Carl D Langefeld, Hugh S Markus, Braxton D Mitchell, Brad B Worrall, Steven J Kittner, Daniel Woo, Martin Dichgans, Jonathan Rosand, Christopher D Anderson
Primary intracerebral haemorrhage and lacunar ischaemic stroke are acute manifestations of progressive cerebral microvascular disease. Current paradigms suggest atherosclerosis is a chronic, dynamic, inflammatory condition precipitated in response to endothelial injury from various environmental challenges. Myeloperoxidase plays a central role in initiation and progression of vascular inflammation, but prior studies linking myeloperoxidase with stroke risk have been inconclusive. We hypothesized that genetic determinants of myeloperoxidase levels influence the development of vascular instability, leading to increased primary intracerebral haemorrhage and lacunar stroke risk...
October 1, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/28963121/animal-models-of-cerebral-amyloid-angiopathy
#14
REVIEW
Lieke Jäkel, William E Van Nostrand, James A R Nicoll, David J Werring, Marcel M Verbeek
Cerebral amyloid angiopathy (CAA), due to vascular amyloid β (Aβ) deposition, is a risk factor for intracerebral haemorrhage and dementia. CAA can occur in sporadic or rare hereditary forms, and is almost invariably associated with Alzheimer's disease (AD). Experimental (animal) models are of great interest in studying mechanisms and potential treatments for CAA. Naturally occurring animal models of CAA exist, including cats, dogs and non-human primates, which can be used for longitudinal studies. However, due to ethical considerations and low throughput of these models, other animal models are more favourable for research...
October 15, 2017: Clinical Science (1979-)
https://www.readbyqxmd.com/read/28959492/characteristics-management-and-response-to-alteplase-in-china-versus-non-china-participants-of-the-enchanted-trial
#15
Lily Song, Xia Wang, Thompson Robinson, Richard I Lindley, Hisatomi Arima, Pablo M Lavados, Xiaoying Chen, John Chalmers, Craig S Anderson
BACKGROUND: The characteristics of patients with acute ischaemic stroke (AIS) and their management vary across regions, which may influence outcomes. We examined for differential patterns of outcome between China and non-China participants of the ENhanced Control of Hypertension And Thrombolysis strokE stuDy (ENCHANTED), which tested different alteplase doses in AIS. METHODS: ENCHANTED was an international, multicentre, open, blinded-endpoint trial of the effects of low-dose (0...
June 2017: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/28959487/current-management-of-spontaneous-intracerebral-haemorrhage
#16
REVIEW
Cyrus K Dastur, Wengui Yu
Intracerebral haemorrhage (ICH) is the most devastating and disabling type of stroke. Uncontrolled hypertension (HTN) is the most common cause of spontaneous ICH. Recent advances in neuroimaging, organised stroke care, dedicated Neuro-ICUs, medical and surgical management have improved the management of ICH. Early airway protection, control of malignant HTN, urgent reversal of coagulopathy and surgical intervention may increase the chance of survival for patients with severe ICH. Intensive lowering of systolic blood pressure to <140 mm Hg is proven safe by two recent randomised trials...
March 2017: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/28959481/brain-iron-overload-following-intracranial-haemorrhage
#17
REVIEW
Thomas Garton, Richard F Keep, Ya Hua, Guohua Xi
Intracranial haemorrhages, including intracerebral haemorrhage (ICH), intraventricular haemorrhage (IVH) and subarachnoid haemorrhage (SAH), are leading causes of morbidity and mortality worldwide. In addition, haemorrhage contributes to tissue damage in traumatic brain injury (TBI). To date, efforts to treat the long-term consequences of cerebral haemorrhage have been unsatisfactory. Incident rates and mortality have not showed significant improvement in recent years. In terms of secondary damage following haemorrhage, it is becoming increasingly apparent that blood components are of integral importance, with haemoglobin-derived iron playing a major role...
December 2016: Stroke and Vascular Neurology
https://www.readbyqxmd.com/read/28956193/decompressive-craniectomy-for-intracerebral-haematoma-the-influence-of-additional-haematoma-evacuation
#18
Alexis Hadjiathanasiou, Patrick Schuss, Inja Ilic, Valeri Borger, Hartmut Vatter, Erdem Güresir
Intracerebral haemorrhage (ICH) may lead to intractable elevation of intracranial pressure (ICP), which may lead to decompressive craniectomy (DC). In this setting, surgical evacuation of ICH is controversially discussed. We therefore analysed radiological and clinical parameters to investigate the influence of additional haematoma evacuation to DC in patients with ICH. Forty-four patients suffering from spontaneous, hypertensive ICH between August 2007 and February 2016 underwent DC with and without ICH evacuation at the author's institution...
September 27, 2017: Neurosurgical Review
https://www.readbyqxmd.com/read/28928910/phase-i-ii-randomized-controlled-trial-of-autologous-bone-marrow-derived-mesenchymal-stem-cell-therapy-for-chronic-stroke
#19
Kam Sze Tsang, Chi Ping Stephanie Ng, Xian Lun Zhu, George Kwok Chu Wong, Gang Lu, Anil Tejbhan Ahuja, Ka Sing Lawrence Wong, Ho Keung Ng, Wai Sang Poon
AIM: To examine the safety and efficacy of mesenchymal stem cell (MSC) therapy for intracerebral haemorrhage with neurological dysfunctions for a year. METHODS: MSC were ex vivo expanded from 29 mL (17-42 mL) autologous bone marrow. Patients were randomized to have two intravenous injections of autologous MSC or placebos in four weeks apart. Neurological functions and clinical outcomes were monitored before treatment and at 12(th), 16(th), 24(th), 36(th) and 60(th) week upon completion of the treatment...
August 26, 2017: World Journal of Stem Cells
https://www.readbyqxmd.com/read/28892278/reflection-on-stroke-deaths-and-end-of-life-stroke-care
#20
Syed Zujajuddin Quadri, Thang Huynh, Cecilia Cappelen-Smith, Nirupama Wijesuriya, Abul Mamun, Roy Beran, Alan Mcdougall, Dennis Cordato
BACKGROUND: The benefit of palliative care referral for severe stroke patients on end-of-life care pathways (EOLCP) is increasingly recognised. Palliative care provides assistance with symptom management and transition to end-of-life care. Advance care planning (ACP) may help accommodate patient/family expectations and guide management. METHOD: Retrospective study of all stroke deaths (2014-2015) at Liverpool Hospital, Sydney, Australia. Data examined included age, co-morbidities, living arrangements, pre-existing ACP, palliative care referral rates and 'survival time'...
September 11, 2017: Internal Medicine Journal
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