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intracerebral haemorrhage

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https://www.readbyqxmd.com/read/29348301/predicting-the-presence-of-macrovascular-causes-in-non-traumatic-intracerebral-haemorrhage-the-diagram-prediction-score
#1
Nina A Hilkens, Charlotte J J van Asch, David J Werring, Duncan Wilson, Gabriël J E Rinkel, Ale Algra, Birgitta K Velthuis, Gérard A P de Kort, Theo D Witkamp, Koen M van Nieuwenhuizen, Frank-Erik de Leeuw, Wouter J Schonewille, Paul L M de Kort, Diederik W J Dippel, Theodora W M Raaymakers, Jeannette Hofmeijer, Marieke J H Wermer, Henk Kerkhoff, Korné Jellema, Irene M Bronner, Michel J M Remmers, Henri Paul Bienfait, Ron J G M Witjes, H Rolf Jäger, Jacoba P Greving, Catharina J M Klijn
OBJECTIVE: A substantial part of non-traumatic intracerebral haemorrhages (ICH) arises from a macrovascular cause, but there is little guidance on selection of patients for additional diagnostic work-up. We aimed to develop and externally validate a model for predicting the probability of a macrovascular cause in patients with non-traumatic ICH. METHODS: The DIagnostic AngioGRAphy to find vascular Malformations (DIAGRAM) study (n=298; 69 macrovascular cause; 23%) is a prospective, multicentre study assessing yield and accuracy of CT angiography (CTA), MRI/ magnetic resonance angiography (MRA) and intra-arterial catheter angiography in diagnosing macrovascular causes in patients with non-traumatic ICH...
January 18, 2018: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/29332564/mesenchymal-stem-cell-therapy-in-intracerebral-haemorrhagic-stroke
#2
Gloria Bedini, Anna Bersano, Elisa R Zanier, Francesca Pischiutta, Eugenio A Parati
BACKGROUND: Spontaneous intracerebral haemorrhage (ICH) is a relatively common fatal disease, with an overall global incidence estimated at 24.6 per 100,000 person-years. Given the high degree of morbidity and mortality associated with ICH, therapies that may have neuroprotective effects are of increasing interest to clinicians. In this last context, cell therapies offer the promise of improving the disease course which cannot be addressed adequately by existing treatments. OBJECTIVE: The aim of this review is to evaluate the protective effects and molecular mechanisms of mesenchymal stem cells (MSCs) on haemorrhagic brain following ICH...
January 10, 2018: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29331631/the-edinburgh-ct-and-genetic-diagnostic-criteria-for-lobar-intracerebral-haemorrhage-associated-with-cerebral-amyloid-angiopathy-model-development-and-diagnostic-test-accuracy-study
#3
Mark A Rodrigues, Neshika Samarasekera, Christine Lerpiniere, Catherine Humphreys, Mark O McCarron, Philip M White, James A R Nicoll, Cathie L M Sudlow, Charlotte Cordonnier, Joanna M Wardlaw, Colin Smith, Rustam Al-Shahi Salman
BACKGROUND: Identification of lobar spontaneous intracerebral haemorrhage associated with cerebral amyloid angiopathy (CAA) is important because it is associated with a higher risk of recurrent intracerebral haemorrhage than arteriolosclerosis-associated intracerebral haemorrhage. We aimed to develop a prediction model for the identification of CAA-associated lobar intracerebral haemorrhage using CT features and genotype. METHODS: We identified adults with first-ever intracerebral haemorrhage diagnosed by CT, who died and underwent research autopsy as part of the Lothian IntraCerebral Haemorrhage, Pathology, Imaging and Neurological Outcome (LINCHPIN) study, a prospective, population-based, inception cohort...
January 10, 2018: Lancet Neurology
https://www.readbyqxmd.com/read/29303797/lack-of-early-improvement-predicts-poor-outcome-following-acute-intracerebral-hemorrhage
#4
Vignan Yogendrakumar, Eric E Smith, Andrew M Demchuk, Richard I Aviv, David Rodriguez-Luna, Carlos A Molina, Yolanda Silva Blas, Imanuel Dzialowski, Adam Kobayashi, Jean-Martin Boulanger, Cheemun Lum, Gord Gubitz, Vasantha Padma, Jayanta Roy, Carlos S Kase, Rohit Bhatia, Myzoon Ali, Patrick Lyden, Michael D Hill, Dar Dowlatshahi
OBJECTIVES: There are limited data as to what degree of early neurologic change best relates to outcome in acute intracerebral hemorrhage. We aimed to derive and validate a threshold for early postintracerebral hemorrhage change that best predicts 90-day outcomes. DESIGN: Derivation: retrospective analysis of collated clinical stroke trial data (Virtual International Stroke Trials Archive). VALIDATION: retrospective analysis of a prospective multicenter cohort study (Prediction of haematoma growth and outcome in patients with intracerebral haemorrhage using the CT-angiography spot sign [PREDICT])...
January 4, 2018: Critical Care Medicine
https://www.readbyqxmd.com/read/29296506/intracerebral-haemorrhage-induced-injury-progression-assessed-by-cross-sectional-photoacoustic-tomography
#5
Jinge Yang, Dan Wu, Guang Zhang, Yuan Zhao, Max Jiang, Xin Yang, Qiwen Xu, Huabei Jiang
In this study, we in vivo examined injury progression after intracerebral haemorrhage (ICH) induced by collagenase in mice using cross-sectional photoacoustic tomography (csPAT). csPAT displayed high resolution with high sensitivity for ICH detection. The PAT images obtained showed high correlation with conventional histologic images. Quantitative analysis of the hematoma areas detected by csPAT showed high consistency with the neurologic deficit score (NDS). By utilizing the dual-wavelength method, the development of the hemoglobin area was monitored...
December 1, 2017: Biomedical Optics Express
https://www.readbyqxmd.com/read/29282142/promoting-recruitment-using-information-management-efficiently-prime-a-stepped-wedge-cluster-randomised-trial-of-a-complex-recruitment-intervention-embedded-within-the-restart-or-stop-antithrombotics-randomised-trial
#6
Amy E Maxwell, Richard A Parker, Jonathan Drever, Anthony Rudd, Martin S Dennis, Christopher J Weir, Rustam Al-Shahi Salman
BACKGROUND: Few interventions are proven to increase recruitment in clinical trials. Recruitment to RESTART, a randomised controlled trial of secondary prevention after stroke due to intracerebral haemorrhage, has been slower than expected. Therefore, we sought to investigate an intervention to boost recruitment to RESTART. METHODS/DESIGN: We conducted a stepped-wedge, cluster randomised trial of a complex intervention to increase recruitment, embedded within the RESTART trial...
December 28, 2017: Trials
https://www.readbyqxmd.com/read/29278306/haematoma-scavenging-in-intracerebral-haemorrhage-from-mechanisms-to-the-clinic
#7
REVIEW
Gaiqing Wang, Li Wang, Xin-Gang Sun, Jiping Tang
The products of erythrocyte lyses, haemoglobin (Hb) and haem, are recognized as neurotoxins and the main contributors to delayed cerebral oedema and tissue damage after intracerebral haemorrhage (ICH). Finding a means to efficiently promote absorption of the haemolytic products (Hb and haem) around the bleeding area in the brain through stimulating the function of the body's own garbage cleaning system is a novel clinical challenge and critical for functional recovery after ICH. In this review, available information of the brain injury mechanisms underlying ICH and endogenous haematoma scavenging system is provided...
December 26, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29260032/longitudinal-clinical-and-neuro-radiological-findings-in-a-patient-with-leukoencephalopathy-with-brain-calcifications-and-cysts-labrune-syndrome
#8
Yasushi Iwasaki, Ken-Ichiro Hoshino, Keiko Mori, Masumi Ito, Yoshinari Kawai, Maya Mimuro, Tamao Tsukie, Takeshi Ikeuchi, Mari Yoshida
Since she was 4 years old, the patient had exhibited frequent convulsive seizures, and she experienced severe headaches and depression in adulthood. At the age of 37 years, cerebral calcifications were detected, but she exhibited no cognitive or motor problems. She suffered a cerebral haemorrhage at 49 years old and experienced cognitive dysfunction, dysarthria, dysphagia, and left-hemiparesis as sequelae. After undergoing gastrostomy, she exhibited very slow cognitive deterioration associated with speech disturbance over more than 10 years...
September 2017: ENeurologicalSci
https://www.readbyqxmd.com/read/29214402/decision-making-and-neurosurgeons-agreement-in-the-management-of-aneurysmal-subarachnoid-haemorrhage-based-on-computed-tomography-angiography
#9
Nicolai Maldaner, Jan-Karl Burkhardt, Martin Nikolaus Stienen, Johannes Goldberg, David Bervini, Philippe Bijlenga, Davide Croci, Daniel Zumofen, Donato D'Alonzo, Serge Marbacher, Rodolfo Maduri, Roy Thomas Daniel, Carlo Serra, Giuseppe Esposito, Marian C Neidert, Oliver Bozinov, Luca Regli
BACKGROUND: To determine the neurosurgeon's agreement in aneurysmal subarachnoid haemorrhage (aSAH) management with special emphasis on the rater's level of experience. A secondary aim was to analyse potential aneurysm variables associated with the therapeutic recommendation. METHOD: Basic clinical information and admission computed tomography angiography (CTA) images of 30 consecutive aSAH patients were provided. Twelve neurosurgeons independently evaluated aneurysm characteristics and gave recommendations regarding the emergency management and aneurysm occlusion therapy...
December 7, 2017: Acta Neurochirurgica
https://www.readbyqxmd.com/read/29204307/treatment-of-intracerebellar-haemorrhage-poor-outcome-and-high-long-term-mortality
#10
Jarno Satopää, Atte Meretoja, Riku J Koivunen, Satu Mustanoja, Jukka Putaala, Markku Kaste, Daniel Strbian, Turgut Tatlisumak, Mika R Niemelä
Background: Intracerebellar haemorrhage constitutes around 10% of all spontaneous, non-aneurysmal intracerebral haemorrhages (ICHs) and often carries a grim prognosis. In symptomatic patients, surgical evacuation is usually regarded the standard treatment. Our objective was to compare the in-hospital mortality and functional outcome at hospital discharge in either medically or surgically treated patients, and the impact of either treatment on long-term mortality after a cerebellar ICH...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/29197413/timing-of-oral-anticoagulant-therapy-in-acute-ischemic-stroke-with-atrial-fibrillation-study-protocol-for-a-registry-based-randomised-controlled-trial
#11
Signild Åsberg, Ziad Hijazi, Bo Norrving, Andreas Terént, Patrik Öhagen, Jonas Oldgren
BACKGROUND: Oral anticoagulation therapy is recommended for the prevention of recurrent ischemic stroke in patients with atrial fibrillation (AF). Current guidelines do not provide evidence-based recommendations on optimal time-point to start anticoagulation therapy after an acute ischemic stroke. Non-vitamin K antagonist oral anticoagulants (NOACs) may offer advantages compared to warfarin because of faster and more predictable onset of action and potentially a lower risk of intracerebral haemorrhage also in the acute phase after an ischemic stroke...
December 2, 2017: Trials
https://www.readbyqxmd.com/read/29187935/-haemorrhagic-stroke-of-the-brainstem-secondary-to-postpartum-eclampsia-about-a-case-and-literature-review
#12
REVIEW
Khadija Ennaqui, Assia Makayssi, Houssine Boufettal, Naima Samouh
Strokes are rare but severe accidents during pregnancy and post-partum period. They are responsible for high mortality and morbidity rates. Pre-eclampsia, eclampsia, and strokes are significantly related. Endothelial dysfunction, alteration of brain self-regulation and severe hypertension are, probably, the cause of many strokes in pregnant women and during postpartum period. We report a case of hemorrhagic stroke of the brainstem in a nonmonitored 21-year old patient at 38 weeks pregnant admitted with severe preeclampsia complicated by eclampsia and then by haemorrhagic stroke of the brainstem on the second post-operative day after cesarean section performed due to suspicion of retroplacental haematoma arisen since her admission...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/29183931/early-low-energy-versus-high-energy-enteral-nutrition-support-in-patients-with-traumatic-intracerebral-haemorrhage-protocol-for-a-randomised-controlled-trial
#13
Yanfei Shen, Xuping Cheng, Manzhen Ying, Weimin Zhang, Xuandong Jiang, Kailei Du
BACKGROUND: Early enteral nutrition (EN) is associated with shorter hospital stay and lower infection and mortality rates in patients with intracerebral haemorrhage. However, high-energy support always causes clinical complications, such as diarrhoea and aspiration pneumonia, and the true benefit of high-energy support in these patients has not been investigated. The appropriate amount of energy support still needs further investigation. Therefore, we are performing a randomised controlled trial to investigate whether early low-energy EN can decrease mortality and feeding-related complications and improve neurological outcomes as compared with high-energy EN in traumatic intracerebral haemorrhage (TICH) patients...
November 28, 2017: BMJ Open
https://www.readbyqxmd.com/read/29175568/borderline-aspect-score-patients-with-acute-ischaemic-stroke-due-to-large-vessel-occlusion-may-find-benefit-with-endovascular-thrombectomy
#14
Caitriona Logan, Julian Maingard, Kevin Phan, Ronan Motyer, Christen Barras, Seamus Looby, Paul Brennan, Alan O'Hare, Duncan Mark Brooks, Ronil V Chandra, Hamed Asadi, Hong Kuan Kok, John Thornton
OBJECTIVE: Selection of patients with acute ischaemic stroke (AIS) for endovascular thrombectomy (EVT) is complex and time-critical. The benefits of EVT are well established for patients with small core infarcts. The aim of this study was to compare clinical outcomes of EVT in patients with larger established infarcts (ASPECTS ≤6), with a smaller infarct group (ASPECTS 7-10). METHODS: 355 patients with AIS due to large vessel occlusion (LVO) who underwent EVT were included...
November 22, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/29157263/ldl-receptor-blockade-reduces-mortality-in-a-mouse-model-of-ischaemic-stroke-without-improving-tissue-type-plasminogen-activator-induced-brain-haemorrhage-towards-pre-clinical-simulation-of-symptomatic-ich
#15
Be'eri Niego, Brad R S Broughton, Heidi Ho, Christopher G Sobey, Robert L Medcalf
BACKGROUND: Symptomatic intracerebral haemorrhage (sICH) following tissue-type plasminogen activator (rt-PA) administration is the most feared and lethal complication of thrombolytic therapy for ischaemic stroke, creating a significant obstacle for a broader uptake of this beneficial treatment. rt-PA also undermines cerebral vasculature stability in a multimodal process which involves engagement with LDL receptor-related protein 1 (LRP-1), potentially underlying the development of sICH...
November 21, 2017: Fluids and Barriers of the CNS
https://www.readbyqxmd.com/read/29152470/fluoroscopy-guided-combined-surgical-endovascular-treatment-of-dural-arteriovenous-fistula
#16
So Hee Park, Jong-Hoon Kim, Chul-Hoon Chang, Young-Jin Jung
For dural arteriovenous fistula (DAVF), when the usual endovascular or neurosurgical approaches are difficult to treat, multi-modal treatment can be helpful. We present a case of a 71-year-old woman with DAVF, who presented with an intracerebral haemorrhage. Digital subtraction angiography revealed a DAVF of the transverse sinus, with cortical venous reflux. Transvenous and transarterial approaches for coil embolization failed. In the operating room, a small craniotomy was performed, and coil embolization was done under fluoroscopy...
June 2017: Journal of Cerebrovascular and Endovascular Neurosurgery
https://www.readbyqxmd.com/read/29128801/oleuropein-protects-intracerebral-hemorrhage-induced-disruption-of-blood-brain-barrier-through-alleviation-of-oxidative-stress
#17
Jing Shi, Guofeng Wu, Xiaohua Zou, Ke Jiang
BACKGROUND: Intracerebral haemorrhage (ICH) as a devastating form of stroke has remained a public health threat due to lack of FDA-approved therapy. Oxidative stress originated from blood cell degradation products plays a crucial role in the ICH pathogenesis. In this study we evaluated oleuropein, a potent natural antioxidant from olive, in a well-established rat ICH model from overall symptoms to detailed molecular mechanism. METHODS: ICH model was established by collagenase injection to the brain of rats, which were randomly divided into groups with vehicle mock treatment, followed by treatment with different doses of oleuropein via daily intraperitoneal injection post-ICH for 3days...
May 11, 2017: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29128343/post-stroke-depression-mechanisms-and-pharmacological-treatment
#18
REVIEW
Roberto Federico Villa, Federica Ferrari, Antonio Moretti
Depression, the most frequent psychiatric disorder following ischaemic stroke, negatively affects survivals' functional outcome, response to rehabilitation and quality of life. Approximately, one-third of them are affected by post-stroke depression (PSD), making it a serious social and public health problem and anti-depressant preventive and curative therapies worth investigating. However, a two-way association between depression and stroke has been also established: stroke increases the risk of PSD, but depression is an independent risk factor for stroke...
November 9, 2017: Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29112977/initial-clinical-experience-with-dual-layer-detector-spectral-ct-in-patients-with-acute-intracerebral-haemorrhage-a-single-centre-pilot-study
#19
Soo Buem Cho, Hye Jin Baek, Kyeong Hwa Ryu, Jin Il Moon, Bo Hwa Choi, Sung Eun Park, Kyungsoo Bae, Kyung Nyeo Jeon, Dong Wook Kim
PURPOSE: The purpose of this study was to investigate the clinical feasibility of spectral analyses using dual-layer detector spectral computed tomography (CT) in acute intracerebral haemorrhage (ICH). MATERIAL AND METHODS: We retrospectively reviewed patients with acute ICH who underwent CT angiography on a dual-layer detector spectral CT scanner. A spectral data analysis was performed to detect contrast enhancement in or adjacent to acute ICH by using spectral image reconstructions including monoenergetic (MonoE), virtual noncontrast (VNC), and iodine overlay fusion images...
2017: PloS One
https://www.readbyqxmd.com/read/29070646/amyloid-pet-burden-and-regional-distribution-in-cerebral-amyloid-angiopathy-a-systematic-review-and-meta-analysis-of-biomarker-performance
#20
Andreas Charidimou, Karim Farid, Hsin-Hsi Tsai, Li-Kai Tsai, Rouh-Fang Yen, Jean-Claude Baron
INTRODUCTION: We performed a meta-analysis to synthesise current evidence on amyloid-positron emission tomography (PET) burden and presumed preferential occipital distribution in sporadic cerebral amyloid angiopathy (CAA). METHODS: In a PubMed systematic search, we identified case-control studies with extractable data on global and occipital-to-global amyloid-PET uptake in symptomatic patients with CAA (per Boston criteria) versus control groups (healthy participants or patients with non-CAA deep intracerebral haemorrhage) and patients with Alzheimer's disease...
October 25, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
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