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JOURNAL ARTICLE
Sea-Yong Kim, Ulla Rasmussen, Sara Rydberg
The neurotoxin β-N-methylamino-L-alanine (BMAA) has emerged as an environmental factor related to neurodegenerative diseases. BMAA is produced by various microorganisms including cyanobacteria and diatoms, in diverse ecosystems. In the diatom Phaeodactylum tricornutum, BMAA is known to inhibit growth. The present study investigated the impact of BMAA on the diatom Thalassiosira pseudonana by exposing it to different concentrations of exogenous BMAA. Metabolomics was predominantly employed to investigate the effect of BMAA on T...
April 5, 2024: Marine Pollution Bulletin
#22
REVIEW
Efstathios T Pavlidis, Ioannis N Galanis, Theodoros E Pavlidis
Colorectal carcinoma is common, particularly on the left side. In 20% of patients, obstruction and ileus may be the first clinical manifestations of a carcinoma that has advanced (stage II, III or even IV). Diagnosis is based on clinical presentation, plain abdominal radiogram, computed tomography (CT), CT colonography and positron emission tomography/CT. The best management strategy in terms of short-term operative or interventional and long-term oncological outcomes remains unknown. For the most common left-sided obstruction, the first choice should be either emergency surgery or endoscopic decompression by self-expendable metal stents or tubes...
March 15, 2024: World Journal of Gastrointestinal Oncology
#23
JOURNAL ARTICLE
Abdiel de Jesús Espinosa-Champo, Gerardo G Naumis
\textit{Holey Graphene} (HG) is a widely used graphene material for the synthesis of high-purity and highly crystalline materials. The electronic properties of a periodic distribution of lattice holes are explored here, demonstrating the emergence of flat bands. It is established that such flat bands arise as a consequence of an induced sublattice site imbalance, i.e., by having more sites in one of the graphene's bipartite sublattice than in the other. This is equivalent to the breaking of a path-exchange symmetry...
April 2, 2024: Journal of Physics. Condensed Matter: An Institute of Physics Journal
#24
JOURNAL ARTICLE
Hager M M Saleh, Areej A Al-Khalaf, Maha Abdullah Alwaili, Debjani Dey
The brinjal fruit and shoot borer (BFSB), Leucinodes orbonalis Guenée (Lepidoptera: Crambidae), is a very detrimental pest that causes significant economic losses to brinjal crop worldwide. Infested brinjal fruits were collected from vegetable fields located at the ICAR-Indian Agricultural Research Institute (ICAR-IARI), New Delhi, India, during two consecutive seasons (2021-2022). The larvae of the pest were brought to the laboratory and reared under controlled conditions of 25 ± 0.5 °C and 70 ± 5% relative humidity, for the emergence of parasitoids...
2024: PeerJ
#25
JOURNAL ARTICLE
Valentin Terhoeven, Sandra Faschingbauer, Julia Huber, Joe J Simon, Wolfgang Herzog, Hans-Christoph Friederich, Christoph Nikendei
BACKGROUND: Patients with anorexia nervosa (AN) show overgeneralization of memory (OGM) when generating autobiographical episodes related to food and body shape. These memories are central for the construction of a coherent self-concept, interpersonal relationships, and problem-solving abilities. The current study aims to investigate changes in autobiographical memory following weight gain. METHODS: OGM was assessed with an adapted version of the Autobiographical Memory Test including food-, body-, depression-related, and neutral cues...
April 1, 2024: European Eating Disorders Review: the Journal of the Eating Disorders Association
#26
JOURNAL ARTICLE
M D Gonzalez-Baz, E Pacheco-Del Cerro, M I Durango-Limárquez, A Alcantarilla-Martín, R Romero-Arribas, J Ledesma-Fajardo, M N Moro-Tejedor
BACKGROUND: The stay in a critical care unit (CCU) has a serious impact on physical condition causing numerous discomfort factors such as pain or difficulty in communicating. All of these are associated with possible sequelae following discharge from the Intensive Care Unit (ICU) named post-ICU syndrome. The Kolcaba Comfort Theory allows, from a holistic approach, to identify care needs from the patient's perspective using instruments such as the General Comfort Questionnaire (GCQ). OBJECTIVES: To determine the comfort level of patients admitted to the CCU using the GCQ of Kolcaba and to identify the discomfort factors...
March 27, 2024: Enfermería intensiva
#27
JOURNAL ARTICLE
Samantha J Moshier, Colin T Mahoney, Michelle J Bovin, Brian P Marx, Paula P Schnurr
OBJECTIVE: To compare the course of change in individual posttraumatic stress disorder (PTSD) symptoms during prolonged exposure therapy (PE) and cognitive processing therapy (CPT). METHOD: We analyzed data from a previously published randomized clinical trial comparing PE and CPT among male and female U.S. military veterans with PTSD (Schnurr et al., 2022). Using data from a self-rated PTSD symptom measure administered before each therapy session, we evaluated individual symptom change from pretreatment to final therapy session ( N = 802)...
March 28, 2024: Journal of Consulting and Clinical Psychology
#28
JOURNAL ARTICLE
Rose C Dimitroyannis, Thomas F Cyberski, Neil S Kondamuri, Sean P Polster, Paramita Das, Peleg M Horowitz, Christopher R Roxbury
BACKGROUND: The concept of "time toxicity" has emerged to address the impact of time spent in the healthcare system; however, little work has examined the phenomenon in the field of otolaryngology. OBJECTIVE: To validate the use of Evaluation and Management (E/M) current procedural terminology codes as a method to assess time burden and to pilot this tool to characterize the time toxicity of office visits associated with a diagnosis of pituitary adenoma between 2016 and 2019...
March 27, 2024: American Journal of Rhinology & Allergy
#29
JOURNAL ARTICLE
E A Zimmerman, I Irani, P Chen, A Gal-Yam, S Schulze, D A Perley, J Sollerman, A V Filippenko, T Shenar, O Yaron, S Shahaf, R J Bruch, E O Ofek, A De Cia, T G Brink, Y Yang, S S Vasylyev, S Ben Ami, M Aubert, A Badash, J S Bloom, P J Brown, K De, G Dimitriadis, C Fransson, C Fremling, K Hinds, A Horesh, J P Johansson, M M Kasliwal, S R Kulkarni, D Kushnir, C Martin, M Matuzewski, R C McGurk, A A Miller, J Morag, J D Neil, P E Nugent, R S Post, N Z Prusinski, Y Qin, A Raichoor, R Riddle, M Rowe, B Rusholme, I Sfaradi, K M Sjoberg, M Soumagnac, R D Stein, N L Strotjohann, J H Terwel, T Wasserman, J Wise, A Wold, L Yan, K Zhang
The early evolution of a supernova (SN) can reveal information about the environment and the progenitor star. When a star explodes in vacuum, the first photons to escape from its surface appear as a brief, hours-long shock-breakout flare1,2 , followed by a cooling phase of emission. However, for stars exploding within a distribution of dense, optically thick circumstellar material (CSM), the first photons escape from the material beyond the stellar edge and the duration of the initial flare can extend to several days, during which the escaping emission indicates photospheric heating3 ...
March 2024: Nature
#30
JOURNAL ARTICLE
Christopher N Morrison, Christina F Mair, Lisa Bates, Dustin T Duncan, Charles C Branas, Brady R Bushover, Christina A Mehranbod, Ariana N Gobaud, Stephen Uong, Sarah Forrest, Leah Roberts, Andrew G Rundle
BACKGROUND: Spatial epidemiology has emerged as an important subfield of epidemiology over the past quarter century. We trace the origins of spatial epidemiology and note that its emergence coincided with technological developments in spatial statistics and geography. We hypothesize that spatial epidemiology makes important contributions to descriptive epidemiology and analytic risk factor studies, but is not yet aligned with epidemiology's current focus on causal inference and intervention...
March 22, 2024: Epidemiology
#31
JOURNAL ARTICLE
G Solanki, T Wilkinson, N G Myburgh, J E Cornell, V Brijlal
The National Assembly approval of the National Health Insurance (NHI) Bill represents an important milestone, but there are many uncertainties concerning its implementation and timeline. The challenges faced by the South African healthcare system are huge, and we cannot afford to wait for NHI to address them all. It is critical that the process of strengthening the health system to advance universal healthcare (UHC) begins now, and there are several viable initiatives that can be implemented without delay. This article examines potential scenarios after the Bill is passed and ways in which UHC could be advanced...
March 18, 2024: South African Medical Journal
#32
JOURNAL ARTICLE
Henri M Garrison-Desany, Jacquelyn L Meyers, Sarah D Linnstaedt, Stacey L House, Francesca L Beaudoin, Xinming An, Donglin Zeng, Thomas C Neylan, Gari D Clifford, Tanja Jovanovic, Laura T Germine, Kenneth A Bollen, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Robert A Swor, Nina T Gentile, Lauren A Hudak, Jose L Pascual, Mark J Seamon, Erica Harris, Claire Pearson, David A Peak, Robert M Domeier, Niels K Rathlev, Brian J O'Neil, Paulina Sergot, Leon D Sanchez, Steven E Bruce, Jutta Joormann, Steven E Harte, Samuel A McLean, Karestan C Koenen, Christy A Denckla
BACKGROUND: Post-traumatic stress disorder (PTSD) and substance use (tobacco, alcohol, and cannabis) are highly comorbid. Many factors affect this relationship, including sociodemographic and psychosocial characteristics, other prior traumas, and physical health. However, few prior studies have investigated this prospectively, examining new substance use and the extent to which a wide range of factors may modify the relationship to PTSD. METHODS: The Advancing Understanding of RecOvery afteR traumA (AURORA) study is a prospective cohort of adults presenting at emergency departments (N = 2,943)...
2024: Frontiers in Psychiatry
#33
JOURNAL ARTICLE
Caroline Melhado, Rachelle Durand, Katie W Russell, Natalya E Polukoff, John Rampton, Rajiv R Iyer, Shannon N Acker, Richele Koehler, Connor Prendergast, Nicholas Stence, Brent O'Neill, Benjamin E Padilla, Ramin Jamshidi, Jennifer A Vaughn, Jennifer S Ronecker, Leigh Selesner, Katrine Lofberg, Michael Regner, Jaclyn Thiessen, Christine Sayama, Ryan G Spurrier, Erin E Ross, Chia-Shang Jason Liu, Jason Chu, Kathryn McNevin, Catherine Beni, Bryce R H Robinson, Ken Linnau, Robert T Buckley, Stephanie D Chao, Akanksha Sabapaty, Elizabeth Tong, Laura M Prolo, Romeo Ignacio, Gretchen Floan Sachs, Peter Kruk, David Gonda, Mark Ryan, Samir Pandya, Korgun Koral, Bruno P Braga, Kurtis Auguste, Aaron R Jensen
INTRODUCTION: Clinical clearance of a child's cervical spine after trauma is often challenging due to impaired mental status or an unreliable neurologic examination. Magnetic resonance imaging (MRI) is the gold standard for excluding ligamentous injury in children but is constrained by long image acquisition times and frequent need for anesthesia. Limited-sequence MRI (LSMRI) is used in evaluating the evolution of traumatic brain injury and may also be useful for cervical spine clearance while potentially avoiding the need for anesthesia...
March 25, 2024: Journal of Trauma and Acute Care Surgery
#34
JOURNAL ARTICLE
Bibian Borst, Tanja Jovanovic, Stacey L House, Steven E Bruce, Nathaniel G Harnett, Alyssa R Roeckner, Timothy D Ely, Lauren A M Lebois, Dmitri Young, Francesca L Beaudoin, Xinming An, Thomas C Neylan, Gari D Clifford, Sarah D Linnstaedt, Laura T Germine, Kenneth A Bollen, Scott L Rauch, John P Haran, Alan B Storrow, Christopher Lewandowski, Paul I Musey, Phyllis L Hendry, Sophia Sheikh, Christopher W Jones, Brittany E Punches, Lauren A Hudak, Jose L Pascual, Mark J Seamon, Elizabeth M Datner, Claire Pearson, David A Peak, Robert M Domeier, Niels K Rathlev, Brian J O'Neil, Paulina Sergot, Leon D Sanchez, Steven E Harte, Karestan C Koenen, Ronald C Kessler, Samuel A McLean, Kerry J Ressler, Jennifer S Stevens, Sanne J H van Rooij
BACKGROUND: Females are more likely to develop posttraumatic stress disorder (PTSD) than males. Impaired inhibition has been identified as mechanism for PTSD development, but studies on the potential sex differences of this neurobiological mechanism and how it relates to PTSD severity and progression are sparse. Here we examined sex differences in neural activation during response inhibition and PTSD following recent trauma. METHODS: Participants (N= 205, 138 female sex assigned at birth) were recruited from emergency departments within 72 hours of a traumatic event...
March 22, 2024: Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
#35
JOURNAL ARTICLE
K Kidia, D Machando, V Dzoro, D Chibanda, M Abas, E Manda, A Mutengerere, T Nyandoro, M Chawarika, D Majichi, J H van Dijk, H Jack
BACKGROUND: We piloted the Friendship Bench-an evidence-based, urban-area task sharing intervention for common mental disorders-in rural Zimbabwe. The intervention combines problem solving therapy with income generating activities. This study sought to understand the intervention's implementation in terms of acceptability, feasibility, and sustainability as well as local attitudes towards mental wellbeing in rural Zimbabwe. METHODS: Using four separate semi-structured interview guides, we conducted in-depth interviews (N = 32) with patients (n = 9), village health workers (n = 12), nurses (n = 6), and community leaders (n = 5)...
March 20, 2024: Social Science & Medicine
#36
JOURNAL ARTICLE
Loren D Peeters, Liza J Wills, Anthony M Cuozzo, Kira L Ivanich, Seth E Turney, Luke P Bullock, Robert M Price, Justin T Gass, Russell W Brown
RATIONALE: Antipsychotic medications that are used to treat psychosis are often limited in their efficacy by high rates of severe side effects. Treatment success in schizophrenia is further complicated by high rates of comorbid nicotine use. Dopamine D2 heteroreceptor complexes have recently emerged as targets for the development of more efficacious pharmaceutical treatments for schizophrenia. OBJECTIVE: The current study sought to explore the use of the positive allosteric modulator of the mGlu5 receptor 3-Cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide (CDPPB) as a treatment to reduce symptoms related to psychosis and comorbid nicotine use...
March 21, 2024: Pharmacology, Biochemistry, and Behavior
#37
REVIEW
Josephine A Taverna, Chia-Nung Hung, Madison Williams, Ryan Williams, Meizhen Chen, Samaneh Kamali, Vaishnavi Sambandam, Cheryl Hsiang-Ling Chiu, Pawel A Osmulski, Maria E Gaczynska, Daniel T DeArmond, Christine Gaspard, Maria Mancini, Meena Kusi, Abhishek N Pandya, Lina Song, Lingtao Jin, Paolo Schiavini, Chun-Liang Chen
Lung cancer is the leading cause of global cancer-related mortality resulting in ∼ 1.8 million deaths annually. Systemic, molecular targeted, and immune therapies have provided significant improvements of survival outcomes for patients. However, drug resistance usually arises and there is an urgent need for novel therapy screening and personalized medicine. 3D patient-derived organoid (PDO) models have emerged as a more effective and efficient alternative for ex vivo drug screening than 2D cell culture and patient-derived xenograft (PDX) models...
March 14, 2024: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
#38
JOURNAL ARTICLE
Mohamed T Khazaal, Ahmed H I Faraag, Hoda H El-Hendawy
BACKGROUND: The emergence of antimicrobial resistance in bacterial pathogens is a growing concern worldwide due to its impact on the treatment of bacterial infections. The "Trojan Horse" strategy has been proposed as a potential solution to overcome drug resistance caused by permeability issues. OBJECTIVE: The objective of our research was to investigate the bactericidal activity and mechanism of action of the "Trojan Horse" strategy using enterobactin conjugated with Ciprofloxacin and Fosfomycin against the antibiotic-resistant Escherichia coli strain OQ866153...
March 22, 2024: BMC Microbiology
#39
JOURNAL ARTICLE
Alina M Hamilton, Andrea Walens, Sarah C Van Alsten, Linnea T Olsson, Joseph Nsonwu-Farley, Xiaohua Gao, Erin L Kirk, Charles M Perou, Lisa A Carey, Melissa A Troester, Yara Abdou
PURPOSE: Survivin/BIRC5 is a proliferation marker that is associated with poor prognosis in breast cancer and an attractive therapeutic target. However, BIRC5 has not been well studied among racially diverse populations where aggressive breast cancers are prevalent. EXPERIMENTAL DESIGN: We studied BIRC5 expression in association with clinical and demographic variables and as a predictor of recurrence in 2174 participants in the Carolina Breast Cancer Study (CBCS), a population-based study that oversampled Black (n = 1113) and younger (< 50 years; n = 1137) participants with breast cancer...
March 21, 2024: Breast Cancer Research: BCR
#40
JOURNAL ARTICLE
Lindsay J Mullin, Joshua Rutsohn, Julia L Gross, Kelly E Caravella, Rebecca L Grzadzinski, Leigh Anne Weisenfeld, Lisa Flake, Kelly N Botteron, Stephen R Dager, Annette M Estes, Juhi Pandey, Robert T Schultz, Tanya St John, Jason J Wolff, Mark D Shen, Joseph Piven, Heather C Hazlett, Jessica B Girault
BACKGROUND: Specifying early developmental differences among neurodevelopmental disorders with distinct etiologies is critical to improving early identification and tailored intervention during the first years of life. Recent studies have uncovered important differences between infants with fragile X syndrome (FXS) and infants with familial history of autism spectrum disorder who go on to develop autism themselves (FH-ASD), including differences in brain development and behavior. Thus far, there have been no studies longitudinally investigating differential developmental skill profiles in FXS and FH-ASD infants...
March 20, 2024: Journal of Neurodevelopmental Disorders
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