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https://www.readbyqxmd.com/read/29765458/analysis-of-web-based-learning-methods-in-emergency-medicine-randomized-controlled-trial
#1
Piotr Leszczyński, Joanna Gotlib, Zbigniew Kopański, Arkadiusz Wejnarski, Stanisław Świeżewski, Robert Gałązkowski
Introduction: In medical education, Web-based learning is increasingly used as a complement to practical classes. The objective of the study was to perform a comparative analysis of three different forms of e-learning course on emergency medicine in terms of an indicator of knowledge growth and students' satisfaction. Material and methods: For the purpose of the study, we developed and implemented a tool in the form of an online course: A - non-animated presentation, B - video, C - interactive video...
April 2018: Archives of Medical Science: AMS
https://www.readbyqxmd.com/read/29765101/favipiravir-t-705-protects-against-nipah-virus-infection-in-the-hamster-model
#2
Brian E Dawes, Birte Kalveram, Tetsuro Ikegami, Terry Juelich, Jennifer K Smith, Lihong Zhang, Arnold Park, Benhur Lee, Takashi Komeno, Yousuke Furuta, Alexander N Freiberg
Nipah and Hendra viruses are recently emerged bat-borne paramyxoviruses (genus Henipavirus) causing severe encephalitis and respiratory disease in humans with fatality rates ranging from 40-75%. Despite the severe pathogenicity of these viruses and their pandemic potential, no therapeutics or vaccines are currently approved for use in humans. Favipiravir (T-705) is a purine analogue antiviral approved for use in Japan against emerging influenza strains; and several phase 2 and 3 clinical trials are ongoing in the United States and Europe...
May 15, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29758416/drug-targets-for-resistant-malaria-historic-to-future-perspectives
#3
REVIEW
Sahil Kumar, T R Bhardwaj, D N Prasad, Rajesh K Singh
New antimalarial targets are the prime need for the discovery of potent drug candidates. In order to fulfill this objective, antimalarial drug researches are focusing on promising targets in order to develop new drug candidates. Basic metabolism and biochemical process in the malaria parasite, i.e. Plasmodium falciparum can play an indispensable role in the identification of these targets. But, the emergence of resistance to antimalarial drugs is an escalating comprehensive problem with the progress of antimalarial drug development...
May 11, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29750866/luminescent-gold-nanocluster-decorated-polymeric-hybrid-particles-with-assembly-induced-emission
#4
Mathew T Hembury, Nataliia Beztsinna, Hamed Asadi, Joep van den Dikkenberg, Johannes D Meeldijk, Wim E Hennink, Tina Vermonden
Ultrasmall gold atom clusters (< 2 nm in diameter) or gold nanoclusters exhibit emergent photonic properties (near-infrared absorption and emission) compared to larger plasmonic gold particles, due to the significant quantization of their conduction band. While single gold nanoclusters properties and applications are being increasingly investigated, little is still known about their behaviour and properties when assembled into suprastructures and even less studies are investigating their use for biomedical applications...
May 11, 2018: Biomacromolecules
https://www.readbyqxmd.com/read/29749045/evidence-for-galnt12-as-a-moderate-penetrance-gene-for-colorectal-cancer
#5
Daniel R Evans, Srividya Venkitachalam, Leslie Revoredo, Amanda T Dohey, Erica Clarke, Julia J Pennell, Amy E Powell, Erina Quinn, Lakshmeswari Ravi, Thomas A Gerken, Jane S Green, Michael O Woods, Kishore Guda
Characterizing moderate penetrance susceptibility genes is an emerging frontier in colorectal cancer (CRC) research. GALNT12 is a strong candidate CRC-susceptibility gene given previous linkage and association studies, and inactivating somatic and germline alleles in CRC patients. Previously, we found rare segregating germline GALNT12 variants in a clinic-based cohort (N = 118) with predisposition for CRC. Here, we screened a new population-based cohort of incident CRC cases (N = 479) for rare (MAF ≤1%) deleterious germline GALNT12 variants...
May 10, 2018: Human Mutation
https://www.readbyqxmd.com/read/29747939/factors-related-to-limitation-of-life-support-within-48h-of-intensive-care-unit-admission-a-multicenter-study
#6
V Blazquez, A Rodríguez, A Sandiumenge, E Oliver, B Cancio, M Ibañez, G Miró, E Navas, M Badía, M D Bosque, M T Jurado, M López, M Llauradó, N Masnou, T Pont, M Bodí
OBJECTIVE: To determine factors related to limitations on life support within 48h of intensive care unit (ICU) admission. STUDY DESIGN: Prospective multicenter study. SETTING: Eleven ICUs. PATIENTS: All patients who died and/or had limitations on life support after ICU admission during a four-month period. VARIABLES: Patient characteristics, hospital characteristics, characteristics of limitations on life support...
May 7, 2018: Medicina Intensiva
https://www.readbyqxmd.com/read/29746206/%C3%AE-t-catenin-a-developmentally-dispensable-disease-linked-member-of-the-%C3%AE-catenin-family
#7
Sergio E Chiarella, Erik E Rabin, Lorena A Ostilla, Annette S Flozak, Cara J Gottardi
α-Catenins are actin-filament binding proteins and critical subunits of the cadherin-catenin cell-cell adhesive complex. They are found in nominally-defined epithelial (E), neural (N), and testis (T) forms transcribed from three distinct genes. While most of α-catenin research has focused on the developmentally essential founding member, αE-catenin, this review discusses recent studies on αT-catenin (CTNNA3), a developmentally dispensable isoform that is emerging as relevant to cardiac, allergic and neurological diseases...
May 10, 2018: Tissue Barriers
https://www.readbyqxmd.com/read/29746190/criterion-a-of-the-ampd-in-hitop
#8
Thomas A Widiger, Bo Bach, Michael Chmielewski, Lee Anna Clark, Colin DeYoung, Christopher J Hopwood, Roman Kotov, Robert F Krueger, Joshua D Miller, Leslie C Morey, Stephanie N Mullins-Sweatt, Christopher J Patrick, Aaron L Pincus, Douglas B Samuel, Martin Sellbom, Susan C South, Jennifer L Tackett, David Watson, Mark H Waugh, Aidan G C Wright, Johannes Zimmermann, R Michael Bagby, David C Cicero, Christopher C Conway, Barbara De Clercq, Anna R Docherty, Nicholas R Eaton, Kelsie T Forbush, J D Haltigan, Masha Y Ivanova, Robert D Latzman, Donald R Lynam, Kristian E Markon, Ulrich Reininghaus, Katherine M Thomas
The categorical model of personality disorder classification in the American Psychiatric Association's Diagnostic and Statistical Manual of Mental Disorders (5th ed. [DSM-5]; American Psychiatric Association, 2013 ) is highly and fundamentally problematic. Proposed for DSM-5 and provided within Section III (for Emerging Measures and Models) was the Alternative Model of Personality Disorder (AMPD) classification, consisting of Criterion A (self-interpersonal deficits) and Criterion B (maladaptive personality traits)...
May 10, 2018: Journal of Personality Assessment
https://www.readbyqxmd.com/read/29744628/impact-of-sylvatic-plague-vaccine-on-non-target-small-rodents-in-grassland-ecosystems
#9
Gebbiena M Bron, Katherine L D Richgels, Michael D Samuel, Julia E Poje, Faye Lorenzsonn, Jonathan P Matteson, Jesse T Boulerice, Jorge E Osorio, Tonie E Rocke
Oral vaccination is an emerging management strategy to reduce the prevalence of high impact infectious diseases within wild animal populations. Plague is a flea-borne zoonosis of rodents that often decimates prairie dog (Cynomys spp.) colonies in the western USA. Recently, an oral sylvatic plague vaccine (SPV) was developed to protect prairie dogs from plague and aid recovery of the endangered black-footed ferret (Mustela nigripes). Although oral vaccination programs are targeted toward specific species, field distribution of vaccine-laden baits can result in vaccine uptake by non-target animals and unintended indirect effects...
May 9, 2018: EcoHealth
https://www.readbyqxmd.com/read/29743793/bone-health-and-impact-of-tenofovir-treatment-in-men-with-hepatitis-b-related-chronic-liver-disease
#10
Kattiparambil G Sajith, Nitin Kapoor, Sahana Shetty, Ashish Goel, Uday Zachariah, Chundamannil E Eapen, Thomas V Paul
Background: Chronic Liver Disease (CLD) has been shown to have an adverse impact on bone health. Hepatitis-B related CLD and its treatment with tenofovir may have additional effects on skeleton. Objective: To study the impact of HBV related CLD and its treatment with Tenofovir on bone health in Indian subjects. Methods: This cross sectional study included men (18-60 years) and comprised of three groups: Group-1 was treatment naïve HBV related CLD ( n  = 79), Group-2 those with HBV related CLD on tenofovir for at least 1 year ( n  = 136), Group-3 age, sex and Body Mass Index (BMI) matched healthy controls ( n  = 58)...
March 2018: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/29739837/nvertx-a-gene-expression-database-to-compare-embryogenesis-and-regeneration-in-the-sea-anemone-nematostella-vectensis
#11
Jacob F Warner, Vincent Guerlais, Aldine R Amiel, Hereroa Johnston, Karine Nedoncelle, Eric Röttinger
For over a century researchers have been comparing embryogenesis and regeneration hoping that lessons learned from embryonic development will unlock hidden regenerative potential. This problem has historically been a difficult one to investigate since the best regenerative model systems are poor embryonic models and vice versa. Recently however, this question has seen renewed interest as emerging models have allowed researchers to investigate these processes in the same organism. This interest has been further fueled by the advent of high-throughput transcriptomic analyses that provide virtual mountains of data...
May 8, 2018: Development
https://www.readbyqxmd.com/read/29735823/antimicrobial-susceptibility-profiles-of-gram-negative-bacteria-causing-infections-collected-across-india-during-2014-2016-study-for-monitoring-antimicrobial-resistance-trend-report
#12
Balaji Veeraraghavan, Mark Ranjan Jesudason, John Antony Jude Prakasah, Shalini Anandan, Rani Diana Sahni, Agila Kumari Pragasam, Yamuna Devi Bakthavatchalam, Rajesh Joseph Selvakumar, T N Dhole, Camilla Rodrigues, Indranil Roy, Sangeetha Joshi, Bhaskar Narayan Chaudhuri, D S Chitnis
Background: The emergence of antibiotic resistance among bacterial pathogens in the hospital and community has increased the concern to the health-care providers due to the limited treatment options. Surveillance of antimicrobial resistance (AMR) in frequently isolated bacterial pathogens causing severe infections is of great importance. The data generated will be useful for the clinicians to decide empiric therapy on the local epidemiological resistance profile of the antimicrobial agents...
January 2018: Indian Journal of Medical Microbiology
https://www.readbyqxmd.com/read/29720564/evidence-that-sedative-effects-of-benzodiazepines-involve-unexpected-gaba-a-receptor-subtypes-quantitative-observation-studies-in-rhesus-monkeys
#13
Angela N Duke, Zhiqiang Meng, Donna M Platt, John R Atack, Gerard R Dawson, David S Reynolds, V V N Phani Babu Tiruveedhula, Guanguan Li, Michael Rajesh Stephen, Werner Sieghart, James M Cook, James K Rowlett
Using non-human primates, we introduced a new set of behavioral categories for observable sedative effects based on pediatric anesthesiology classifications. We examined the effects of alprazolam and diazepam (non-selective benzodiazepines), zolpidem (preferential binding to α1 subunit-containing GABAA receptors), HZ-166 (8-ethynyl-6-(2'-pyridine)-4H-2,5,10b-triaza-benzo[e]azulene-3-carboxylic acid ethyl ester; functionally selective for α2 and α3 subunit-containing GABAA receptors), MRK-696 (7-cyclobutyl-6-(2-methyl-2H-1,2,4-triazol-2-ylmethoxy)-3-(2-flurophenyl)-1,2,4-triazolo(4,3-b)pyridazine; no selectivity but partial intrinsic activity), and TPA023B (6,2'-difluro-5'-(3-(1-hydroxy-1-methylethyl)imidazo(1,2-b((1,2,4)triazin-7-yl)(1,1'-biphenyl)-2-carbonitrile; selectivity for α2, α3, α5 subunit-containing GABAA receptors) using quantitative behavioral observation techniques in rhesus monkeys...
May 2, 2018: Journal of Pharmacology and Experimental Therapeutics
https://www.readbyqxmd.com/read/29720238/two-versus-five-days-of-antibiotics-after-appendectomy-for-complex-acute-appendicitis-appic-study-protocol-for-a-randomized-controlled-trial
#14
Anne Loes van den Boom, Elisabeth M L de Wijkerslooth, Joost van Rosmalen, Frédérique H Beverdam, Evert-Jan G Boerma, Marja A Boermeester, Joanna W A M Bosmans, Thijs A Burghgraef, Esther C J Consten, Imro Dawson, Jan Willem T Dekker, Marloes Emous, Anna A W van Geloven, Peter M N Y H Go, Luc A Heijnen, Sander A Huisman, Dayanara Jean Pierre, Joske de Jonge, Jurian H Kloeze, Marc A Koopmanschap, Hester R Langeveld, Misha D P Luyer, Damian C Melles, Johan W Mouton, Augustinus P T van der Ploeg, Floris B Poelmann, Jeroen E H Ponten, Charles C van Rossem, Wilhelmina H Schreurs, Joël Shapiro, Pascal Steenvoorde, Boudewijn R Toorenvliet, Joost Verhelst, Hendt P Versteegh, Rene M H Wijnen, Bas P L Wijnhoven
BACKGROUND: Acute appendicitis is one of the most common indications for emergency surgery. In patients with a complex appendicitis, prolonged antibiotic prophylaxis is recommended after appendectomy. There is no consensus regarding the optimum duration of antibiotics. Guidelines propose 3 to 7 days of treatment, but shorter courses may be as effective in the prevention of infectious complications. At the same time, the global issue of increasing antimicrobial resistance urges for optimization of antibiotic strategies...
May 2, 2018: Trials
https://www.readbyqxmd.com/read/29719428/factors-associated-with-imaging-in-patients-with-early-breast-cancer-after-initial-treatment
#15
K Enright, T Desai, R Sutradhar, A Gonzalez, M Powis, N Taback, C M Booth, M E Trudeau, M K Krzyzanowska
Background: Overuse of surveillance imaging in patients after curative treatment for early breast cancer (ebc) was recently identified as one of the Choosing Wisely Canada initiatives to improve the quality of cancer care. We undertook a population-level examination of imaging practices in Ontario as they existed before the launch of that initiative. Methods: Patients diagnosed with ebc between 2006 and 2010 in Ontario were identified from the Ontario Cancer Registry...
April 2018: Current Oncology
https://www.readbyqxmd.com/read/29718247/emerging-resistance-mutations-in-pi-naive-patients-failing-an-atazanavir-based-regimen-anrs-multicentre-observational-study
#16
S Lambert-Niclot, M Grude, M L Chaix, C Charpentier, S Reigadas, H Le Guillou-Guillemette, A Rodallec, C Amiel, A Maillard, J Dufayard, T Mourez, A Mirand, J Guinard, B Montes, S Vallet, A G Marcelin, D Descamps, P Flandre, C Delaugerre, L Morand-Joubert
Background: Atazanavir is a PI widely used as a third agent in combination ART. We aimed to determine the prevalence and the patterns of resistance in PI-naive patients failing on an atazanavir-based regimen. Methods: We analysed patients failing on an atazanavir-containing regimen used as a first line of PI therapy. We compared the sequences of reverse transcriptase and protease before the introduction of atazanavir and at failure [two consecutive viral loads (VLs) >50 copies/mL]...
April 27, 2018: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/29709038/hcmv-triggers-frequent-and-persistent-ul40-specific-unconventional-hla-e-restricted-cd8-t-cell-responses-with-potential-autologous-and-allogeneic-peptide-recognition
#17
Nicolas Jouand, Céline Bressollette-Bodin, Nathalie Gérard, Magali Giral, Pierrick Guérif, Audrey Rodallec, Romain Oger, Tiphaine Parrot, Mathilde Allard, Anne Cesbron-Gautier, Nadine Gervois, Béatrice Charreau
Immune response against human cytomegalovirus (HCMV) includes a set of persistent cytotoxic NK and CD8 T cells devoted to eliminate infected cells and to prevent reactivation. CD8 T cells against HCMV antigens (pp65, IE1) presented by HLA class-I molecules are well characterized and they associate with efficient virus control. HLA-E-restricted CD8 T cells targeting HCMV UL40 signal peptides (HLA-EUL40) have recently emerged as a non-conventional T-cell response also observed in some hosts. The occurrence, specificity and features of HLA-EUL40 CD8 T-cell responses remain mostly unknown...
April 30, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29706186/data-driven-prioritisation-of-antibody-drug-conjugate-targets-in-head-and-neck-squamous-cell-carcinoma
#18
Saskia H Hanemaaijer, Stephanie E van Gijn, Sjoukje F Oosting, Boudewijn E C Plaat, Kirsten L Moek, Ed M Schuuring, Bernard F A M van der Laan, Jan L N Roodenburg, Marcel A T M van Vugt, Bert van der Vegt, Rudolf S N Fehrmann
BACKGROUND: For patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC) palliative treatment options that improve overall survival are limited. The prognosis in this group remains poor and there is an unmet need for new therapeutic options. An emerging class of therapeutics, targeting tumor-specific antigens, are antibodies bound to a cytotoxic agent, known as antibody-drug conjugates (ADCs). The aim of this study was to prioritize ADC targets in HNSCC. METHODS: With a systematic search, we identified 55 different ADC targets currently targeted by registered ADCs and ADCs under clinical evaluation...
May 2018: Oral Oncology
https://www.readbyqxmd.com/read/29700995/overnight-sleep-duration-and-obesity-in-2-5-year-old-american-indian-children
#19
D G Ingram, L A Irish, E J Tomayko, R J Prince, K A Cronin, T Parker, K Kim, L Carmichael, V M Grant, J N Sheche, A K Adams
BACKGROUND: Sleep has emerged as a potentially modifiable risk factor for obesity in children. OBJECTIVES: The purpose of this investigation was to evaluate the association between overnight sleep duration and obesity among American Indian (AI) children ages 2-5 years. METHODS: Data were examined from the baseline assessment of children enrolling in the Healthy Children, Strong Families study, which is a randomized lifestyle intervention trial in five diverse rural and urban AI communities nationally among children ages 2-5 years...
April 26, 2018: Pediatric Obesity
https://www.readbyqxmd.com/read/29691892/congenital-titinopathy-comprehensive-characterisation-and-pathogenic-insights
#20
Emily C Oates, Kristi J Jones, Sandra Donkervoort, Amanda Charlton, Susan Brammah, John E Smith, James S Ware, Kyle S Yau, Lindsay C Swanson, Nicola Whiffin, Anthony J Peduto, Adam Bournazos, Leigh B Waddell, Michelle A Farrar, Hugo A Sampaio, Hooi Ling Teoh, Phillipa J Lamont, David Mowat, Robin B Fitzsimons, Alastair J Corbett, Monique M Ryan, Gina L O'Grady, Sarah A Sandaradura, Roula Ghaoui, Himanshu B Joshi, Jamie L Marshall, Melinda A Nolan, Simranpreet Kaur, Jaya Punetha, Ana Töpf, Elizabeth Harris, Madhura Bakshi, Casie A Genetti, Minttu Marttila, Ulla Werlauff, Nathalie Streichenberger, Alan Pestronk, Ingrid Mazanti, Jason R Pinner, Carole Vuillerot, Carla Grosmann, Ana Camacho, Payam Mohassel, Meganne E Leach, A Reghan Foley, Diana Bharucha-Goebel, James Collins, Anne M Connolly, Heather R Gilbreath, Susan T Iannaccone, Diana Castro, Beryl B Cummings, Richard I Webster, Leïla Lazaro, John Vissing, Sandra Coppens, Nicolas Deconinck, Ho-Ming Luk, Neil H Thomas, Nicola C Foulds, Marjorie A Illingworth, Sian Ellard, Catriona A McLean, Rahul Phadke, Gianina Ravenscroft, Nanna Witting, Peter Hackman, Isabelle Richard, Sandra T Cooper, Erik-Jan Kamsteeg, Eric P Hoffman, Kate Bushby, Volker Straub, Bjarne Udd, Ana Ferreiro, Kathryn N North, Nigel F Clarke, Monkol Lek, Alan H Beggs, Carsten G Bönnemann, Daniel G MacArthur, Henk Granzier, Mark R Davis, Nigel G Laing
OBJECTIVE: Comprehensive clinical characterisation of congenital titinopathy to facilitate diagnosis and management of this important emerging disorder. METHODS: Using massively parallel sequencing we identified 30 patients from 27 families with two pathogenic nonsense, frameshift and/or splice site TTN mutations in trans. We then undertook a detailed analysis of the clinical, histopathology and imaging features of these patients. RESULTS: All patients had prenatal- or early-onset hypotonia and/or congenital contractures...
April 25, 2018: Annals of Neurology
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