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https://www.readbyqxmd.com/read/28535235/effect-of-cephalexin-plus-trimethoprim-sulfamethoxazole-vs-cephalexin-alone-on-clinical-cure-of-uncomplicated-cellulitis-a-randomized-clinical-trial
#1
Gregory J Moran, Anusha Krishnadasan, William R Mower, Fredrick M Abrahamian, Frank LoVecchio, Mark T Steele, Richard E Rothman, David J Karras, Rebecca Hoagland, Stephanie Pettibone, David A Talan
Importance: Emergency department visits for skin infections in the United States have increased with the emergence of methicillin-resistant Staphylococcus aureus (MRSA). For cellulitis without purulent drainage, β-hemolytic streptococci are presumed to be the predominant pathogens. It is unknown if antimicrobial regimens possessing in vitro MRSA activity provide improved outcomes compared with treatments lacking MRSA activity. Objective: To determine whether cephalexin plus trimethoprim-sulfamethoxazole yields a higher clinical cure rate of uncomplicated cellulitis than cephalexin alone...
May 23, 2017: JAMA: the Journal of the American Medical Association
https://www.readbyqxmd.com/read/28534359/e-cadherin-in-gastric-carcinomas-relations-with-histological-parameters-and-its-prognostic-value
#2
Dimitrios Schizas, Demetrios Moris, Adamantios Michalinos, Prodromos Kanavidis, Dimitrios Oikonomou, Alexandros Papalampros, Anastasios Machairas, Theodoros Liakakos
PURPOSE: Gastric cancer (GC) is still one of the most common malignancies with the majority of the tumors being diagnosed at advanced stage. The need for identification of prognostic and early detection biomarkers is thus compulsory. E-cadherin is one of the emerging biomarkers that is currently evaluated in the literature in the frame of epithelial-mesenchymal transition (EMT). Our aim was to study the expression of E-cadherin in the various histological subtypes of GC and to evaluate its prognostic value...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28524662/x-ray-emission-spectroscopy-of-biomimetic-mn-coordination-complexes
#3
Scott C Jensen, Katherine M Davis, Brendan T Sullivan, Daniel A Hartzler, Gerald T Seidler, Diego M Casa, Elina Kasman, Hannah E Colmer, Allyssa A Massie, Timothy A Jackson, Yulia N Pushkar
Understanding the function of Mn ions in biological and chemical redox catalysis requires precise knowledge of their electronic structure. X-ray emission spectroscopy (XES) is an emerging technique with growing application to biological and biomimetic systems. Here, we report an improved, cost-effective spec-trometer used to analyze two biomimetic coordination compounds: [MnIV(OH)2(Me2EBC)]2+ and [MnIV(O)(OH)(Me2EBC)]+, the second of which contains a key MnIV=O structural fragment. Despite having the same formal oxidation state (MnIV) and tetradentate ligands, XES spectra from these two compounds demonstrate different electronic structures...
May 19, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28513417/carriage-of-extended-spectrum-beta-lactamase-producing-enterobacteriaceae-in-hiv-infected-children-in-zimbabwe
#4
S M S Wilmore, K Kranzer, A Williams, B Makamure, A F Nhidza, J Mayini, T Bandason, J Metcalfe, M P Nicol, I Balakrishnan, M J Ellington, N Woodford, S Hopkins, T D McHugh, R A Ferrand
BACKGROUND: Antimicrobial resistance is an emerging global health issue. Data on the epidemiology of multidrug-resistant organisms are scarce for Africa, especially in HIV-infected individuals who often have frequent contact with healthcare. We investigated the prevalence of extended-spectrum beta-lactamase-producing Enterobacteriaceae (ESBL-E) carriage in stool among HIV-infected children attending an HIV outpatient department in Harare, Zimbabwe. METHODS: We recruited children who were stable on antiretroviral therapy (ART) attending a HIV clinic from August 2014 to June 2015...
May 2017: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/28513150/production-of-caproic-acid-from-mixed-organic-waste-an-environmental-life-cycle-perspective
#5
Wei-Shan Chen, David P B T B Strik, Cees J N Buisman, Carolien Kroeze
Caproic acid is an emerging platform chemical with diverse applications. Recently, a novel biorefinery process, i.e. chain elongation, was developed to convert mixed organic waste and ethanol into renewable caproic acids. In the coming years, this process may become commercialised, and continuing to improve on the basis of numerous ongoing technological and microbiological studies. This study aims to analyse the environmental performance of caproic acid production from mixed organic waste via chain elongation at this current, early stage of technological development...
May 17, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28508202/ozone-concentration-in-the-ground-atmosphere-and-morbidity-during-extreme-heat-in-the-summer-of-2010
#6
S N Kotelnikov, E V Stepanov, V T Ivashkin
Dependence of the population morbidity on the ground-level ozone concentration in the summer of 2010 was studied in a city with low urbanization (Vyatskie Polyany, Kirov oblast) and in Moscow. At a high air temperature and low ozone concentration, the population morbidity was not associated with these parameters in Vyatskie Polyany. When the average daily ground-level ozone concentration exceeded 60 μg/m(3) for 13 successive days, the correlation coefficient between ozone concentration and the number of ambulance calls was statistically significant, r = 0...
March 2017: Doklady Biological Sciences: Proceedings of the Academy of Sciences of the USSR, Biological Sciences Sections
https://www.readbyqxmd.com/read/28503840/a-critical-note-on-treatment-of-a-severe-diltiazem-intoxication-high-dose-calcium-and-glucagon-infusions
#7
N M Van Veggel, G J Van der Veen, T C Jansen, E M Westerman
The morbidity and mortality of a severe calcium channel blocker intoxication is high due to serious toxic cardiac effects. Its treatment is supported by low-quality evidence from heterogeneous literature. We describe a case of a severe diltiazem intoxication and critically appraise the efficacy and role of high-dose calcium and glucagon infusions. A 53-year-old woman was admitted to the emergency department with a cardiogenic shock with complete AV block, not responding to atropine, isoprenaline and an external pacemaker...
May 15, 2017: Basic & Clinical Pharmacology & Toxicology
https://www.readbyqxmd.com/read/28503348/emerging-trends-in-the-epidemiological-pattern-of-head-and-neck-cancers-in-lagos-nigeria
#8
O A Erinoso, E Okoturo, O M Gbotolorun, O A Effiom, N A Awolola, S S Soyemi, R T Oluwakuyide
BACKGROUND: Unfortunately, despite an increase in medical knowledge, survival rates of head and neck cancers (HNCs) have not been observed to improve greatly. This is true, especially in tumors located in obscure primary sites or late presentation. AIM: The purpose of this study is to assess the epidemiologic pattern of HNCs and to evaluate its emerging trends and patterns in Lagos state. SUBJECTS AND METHODS: A retrospective study was conducted from 2003 to 2013 that analyzed histologically diagnosed cases of HNC at the Pathology Departments of the two tertiary teaching hospitals in Lagos...
September 2016: Annals of Medical and Health Sciences Research
https://www.readbyqxmd.com/read/28500246/closing-the-theory-to-practice-gap-for-newly-qualified-doctors-evaluation-of-a-peer-delivered-practical-skills-training-course-for-newly-qualified-doctors-in-preparation-for-clinical-practice
#9
A Beane, A Padeniya, A P De Silva, T Stephens, S De Alwis, P G Mahipala, P C Sigera, S Munasinghe, P Weeratunga, D Ranasinghe, E M Deshani, T Weerasinghe, K Thilakasiri, Kas Jayasinghe, A M Dondorp, R Haniffa
PURPOSE: The Good Intern Programme (GIP) in Sri Lanka has been implemented to bridge the 'theory to practice gap' of doctors preparing for their internship. This paper evaluates the impact of a 2-day peer-delivered Acute Care Skills Training (ACST) course as part of the GIP. STUDY DESIGN: The ACST course was developed by an interprofessional faculty, including newly graduated doctors awaiting internship (pre-intern), focusing on the recognition and management of common medical and surgical emergencies...
May 12, 2017: Postgraduate Medical Journal
https://www.readbyqxmd.com/read/28494760/the-picture-talk-project-starting-a-conversation-with-community-leaders-on-research-with-remote-aboriginal-communities-of-australia
#10
E F M Fitzpatrick, G Macdonald, A L C Martiniuk, H D'Antoine, J Oscar, M Carter, T Lawford, E J Elliott
BACKGROUND: Researchers are required to seek consent from Indigenous communities prior to conducting research but there is inadequate information about how Indigenous people understand and become fully engaged with this consent process. Few studies evaluate the preference or understanding of the consent process for research with Indigenous populations. Lack of informed consent can impact on research findings. METHODS: The Picture Talk Project was initiated with senior Aboriginal leaders of the Fitzroy Valley community situated in the far north of Western Australia...
May 11, 2017: BMC Medical Ethics
https://www.readbyqxmd.com/read/28490923/multigene-expression-profile-testing-in-breast-cancer-is-there-a-role-for-family-physicians
#11
M A O'Brien, J C Carroll, D P Manca, B Miedema, P A Groome, T Makuwaza, J Easley, N Sopcak, L Jiang, K Decker, M L McBride, R Moineddin, J A Permaul, R Heisey, E A Eisenhauer, M K Krzyzanowska, S Pruthi, C Sawka, N Schneider, J Sussman, R Urquhart, C Versaevel, E Grunfeld
BACKGROUND: Family physicians (fps) play a role in aspects of personalized medicine in cancer, including assessment of increased risk because of family history. Little is known about the potential role of fps in supporting cancer patients who undergo tumour gene expression profile (gep) testing. METHODS: We conducted a mixed-methods study with qualitative and quantitative components. Qualitative data from focus groups and interviews with fps and cancer specialists about the role of fps in breast cancer gep testing were obtained during studies conducted within the pan-Canadian canimpact research program...
April 2017: Current Oncology
https://www.readbyqxmd.com/read/28487019/dynamic-contrast-enhanced-mri-of-the-placenta-a-tool-for-prenatal-diagnosis-of-placenta-accreta
#12
A E Millischer, B Deloison, S Silvera, Y Ville, N Boddaert, D Balvay, N Siauve, C A Cuenod, V Ttsatsaris, L Sentilhes, L J Salomon
BACKGROUND: Ultrasound (US) is the primary imaging modality for the diagnosis of placenta accreta, but it is not sufficiently accurate. MRI morphologic criteria have recently emerged as a useful tool in this setting, but their analysis is too subjective. Recent studies suggest that gadolinium enhancement may help to distinguish between the stretched myometrium and placenta within a scar area. However, objective MRI criteria are still required for prenatal diagnosis of placenta accreta...
May 2017: Placenta
https://www.readbyqxmd.com/read/28481634/outpatient-follow-up-after-mild-traumatic-brain-injury-results-of-the-upfront-study
#13
M E de Koning, M E Scheenen, H J van der Horn, G Hageman, G Roks, T Yilmaz, J M Spikman, J van der Naalt
OBJECTIVE: To investigate outpatient follow-up after mild traumatic brain injury (mTBI) by various medical specialists, for both hospitalized and non-hospitalized patients, and to study guideline adherence regarding hospital admission. METHODS: Patients (n = 1151) with mTBI recruited from the emergency department received questionnaires 2 weeks (n = 879), 3 months (n = 780) and 6 months (n = 668) after injury comprising outpatient follow-up by various health care providers, and outcome defined by the Glasgow Outcome Scale Extended (GOS-E) after 6 months...
May 8, 2017: Brain Injury: [BI]
https://www.readbyqxmd.com/read/28481563/mother-child-interactions-at-six-months-postpartum-are-not-predicted-by-maternal-histories-of-abuse-and-neglect-or-maltreatment-type
#14
Minden B Sexton, Margaret T Davis, Rena Menke, Greer A Raggio, Maria Muzik
OBJECTIVE: A history of childhood maltreatment (CM) is associated with increased rates of maternal psychiatric symptoms and other adverse outcomes in adulthood among postpartum women. However, to date only a few studies have examined associations between CM and mother-child interactions among a nonclinical sample of postpartum women, and the specific potential influence of the type of abuse or neglect is poorly understood. This study was an aim to examine the relationships between CM types and observed parenting in a nonclinical group of recently postpartum mothers with maltreatment histories...
May 8, 2017: Psychological Trauma: Theory, Research, Practice and Policy
https://www.readbyqxmd.com/read/28479278/the-relationship-between-genetic-risk-variants-with-brain-structure-and-function-in-bipolar-disorder-a-systematic-review-of-genetic-neuroimaging-studies
#15
REVIEW
Licia P Pereira, Cristiano A Köhler, Rafael T de Sousa, Marco Solmi, Bárbara P de Freitas, Michele Fornaro, Rodrigo Machado-Vieira, Kamilla W Miskowiak, Eduard Vieta, Nicola Veronese, Brendon Stubbs, André F Carvalho
Genetic-neuroimaging paradigms could provide insights regarding the pathophysiology of bipolar disorder (BD). Nevertheless, findings have been inconsistent across studies. A systematic review of gene-imaging studies involving individuals with BD was conducted across electronic major databases from inception until January 9th, 2017. Forty-four studies met eligibility criteria (N=2122 BD participants). Twenty-six gene variants were investigated across candidate gene studies and 4 studies used a genome-wide association approach...
May 4, 2017: Neuroscience and Biobehavioral Reviews
https://www.readbyqxmd.com/read/28474931/multifaceted-quadruplet-of-low-lying-spin-zero-states-in-66-ni-emergence-of-shape-isomerism-in-light-nuclei
#16
S Leoni, B Fornal, N Mărginean, M Sferrazza, Y Tsunoda, T Otsuka, G Bocchi, F C L Crespi, A Bracco, S Aydin, M Boromiza, D Bucurescu, N Cieplicka-Oryǹczak, C Costache, S Călinescu, N Florea, D G Ghiţă, T Glodariu, A Ionescu, Ł W Iskra, M Krzysiek, R Mărginean, C Mihai, R E Mihai, A Mitu, A Negreţ, C R Niţă, A Olăcel, A Oprea, S Pascu, P Petkov, C Petrone, G Porzio, A Şerban, C Sotty, L Stan, I Ştiru, L Stroe, R Şuvăilă, S Toma, A Turturică, S Ujeniuc, C A Ur
A search for shape isomers in the ^{66}Ni nucleus was performed, following old suggestions of various mean-field models and recent ones, based on state-of-the-art Monte Carlo shell model (MCSM), all considering ^{66}Ni as the lightest nuclear system with shape isomerism. By employing the two-neutron transfer reaction induced by an ^{18}O beam on a ^{64}Ni target, at the sub-Coulomb barrier energy of 39 MeV, all three lowest-excited 0^{+} states in ^{66}Ni were populated and their γ decay was observed by γ-coincidence technique...
April 21, 2017: Physical Review Letters
https://www.readbyqxmd.com/read/28473323/gabaa-receptor-%C3%AE-4-subunit-knockout-enhances-lung-inflammation-and-airway-reactivity-in-a-murine-asthma-model
#17
Gene T Yocum, Damian L Turner, Jennifer Danielsson, Matthew B Barajas, Yi Zhang, Dingbang Xu, Neil Harrison, Gregg E Homanics, Donna L Farber, Charles W Emala
Emerging evidence indicates that hypnotic anesthetics affect immune function. Many anesthetics potentiate γ-aminobutyric acid A receptor (GABAAR) activation, and these receptors are expressed on multiple subtypes of immune cells, providing a potential mechanistic link. Like immune cells, airway smooth muscle (ASM) cells also express GABAARs, particularly isoforms containing α4 subunits, and activation of these receptors leads to ASM relaxation. We sought to determine if GABAAR signaling modulates the ASM contractile and inflammatory phenotype of a murine allergic asthma model utilizing GABAAR α4 subunit global knockout (KO; Gabra4(0/0)) mice...
May 4, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/28463958/prospective-study-of-dna-methylation-at-chromosome-8q24-in-peripheral-blood-and-prostate-cancer-risk
#18
Kathryn Hughes Barry, Lee E Moore, Joshua N Sampson, Stella Koutros, Liying Yan, Ann Meyer, Mahitha Reddy, Andrew J Oler, Michael B Cook, Joseph F Fraumeni, Meredith Yeager, Laufey T Amundadottir, Sonja I Berndt
BACKGROUND: Chromosome 8q24 has emerged as an important genetic susceptibility region for several cancers, including prostate cancer; however, little is known about the contribution of DNA methylation in this region to risk. METHODS: We prospectively evaluated DNA methylation at 8q24 in relation to prostate cancer using pre-diagnostic blood samples from 694 prostate cancer cases (including 172 aggressive cases) and 703 controls in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial...
May 23, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28439531/genome-and-cd4-t-cell-methylome-wide-association-study-of-circulating-trimethylamine-n-oxide-in-the-genetics-of-lipid-lowering-drugs-and-diet-network-goldn
#19
Stella Aslibekyan, Marguerite R Irvin, Bertha A Hidalgo, Rodney T Perry, Elias J Jeyarajah, Erwin Garcia, Irina Shalaurova, Paul N Hopkins, Michael A Province, Hemant K Tiwari, Jose M Ordovas, Devin M Absher, Donna K Arnett
BACKGROUND: Trimethylamine-N-oxide (TMAO), an atherogenic metabolite species, has emerged as a possible new risk factor for cardiovascular disease. Animal studies have shown that circulating TMAO levels are regulated by genetic and environmental factors. However, large-scale human studies have failed to replicate the observed genetic associations, and epigenetic factors such as DNA methylation have never been examined in relation to TMAO levels. METHODS AND RESULTS: We used data from the family-based Genetics of Lipid Lowering Drugs and Diet Network (GOLDN) to investigate the heritable determinants of plasma TMAO in humans...
June 2017: Journal of Nutrition & Intermediary Metabolism
https://www.readbyqxmd.com/read/28438939/emergence-and-evolution-of-multidrug-resistant-klebsiella-pneumoniae-with-both-blakpc-and-blactx-m-integrated-in-chromosome
#20
Weihua Huang, Guiqing Wang, Robert Sebra, Jian Zhuge, Changhong Yin, Maria E Aguero-Rosenfeld, Audrey N Schuetz, Nevenka Dimitrova, John T Fallon
The extended-spectrum β-lactamase (ESBL)- and Klebsiella pneumoniae carbapenemase (KPC)-producing Enterobacteriaceae represent serious and urgent threats to public health. In a retrospective study of multidrug-resistant K. pneumoniae, we identified three clinical isolates, CN1, CR14 and NY9, carrying both blaCTX-M and blaKPC genes. The complete genomes of these three K. pneumoniae isolates were de novo assembled by using both short- and long-read whole-genome sequencing. In CR14 and NY9, blaCTX-M and blaKPC were carried on two different plasmids...
April 24, 2017: Antimicrobial Agents and Chemotherapy
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