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https://www.readbyqxmd.com/read/28722206/alcohol-consumption-and-risk-of-urothelial-cell-bladder-cancer-in-the-european-prospective-investigation-into-cancer-and-nutrition-cohort
#1
E Botteri, P Ferrari, N Roswall, A Tjønneland, A Hjartåker, J M Huerta, R T Fortner, A Trichopoulou, A Karakatsani, C La Vecchia, V Pala, A Perez-Cornago, E Sonestedt, F Liedberg, K Overvad, M J Sánchez, I T Gram, M Stepien, L Trijsburg, L Börje, M Johansson, T Kühn, S Panico, R Tumino, H B Bueno-de-Mesquita, E Weiderpass
Findings on the association between alcohol consumption and bladder cancer are inconsistent. We investigated that association in the European Prospective Investigation into Cancer and Nutrition cohort. We included 476,160 individuals mostly aged 35-70 years, enrolled in ten countries and followed for 13.9 years on average. Hazard ratios (HR) for developing urothelial cell carcinoma (UCC; 1,802 incident cases) were calculated using Cox proportional hazards models. Alcohol consumption at baseline and over the life course was analyzed, as well as different types of beverages (beer, wine, spirits)...
July 19, 2017: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/28717986/thrombolysis-for-stroke-in-ireland-increasing-access-and-maintaining-safety-in-a-challenging-environment
#2
P McElwaine, J McCormack, C Brennan, H Coetzee, P Cotter, R Doyle, A Hickey, F Horgan, C Loughnane, C Macey, P Marsden, D McCabe, R Mulcahy, I Noone, E Shelley, T Stapleton, D Williams, P Kelly, J Harbison
BACKGROUND: In the setting of a national audit of acute stroke services, we examined the delivery of thrombolytic therapy for ischaemic stroke and whether current practice was achieving safe outcomes and consistent delivery for patients. METHOD: Data obtained from the recent national stroke audit was compared against previous Irish audit, the most recent SSNAP UK stroke audit and the Safe Implementation of Thrombolysis in Stroke-Monitoring Study (SITS-MOST) study...
July 17, 2017: Irish Journal of Medical Science
https://www.readbyqxmd.com/read/28716152/development-of-a-theory-informed-implementation-intervention-to-improve-the-triage-treatment-and-transfer-of-stroke-patients-in-emergency-departments-using-the-theoretical-domains-framework-tdf-the-t-3-trial
#3
Louise E Craig, Natalie Taylor, Rohan Grimley, Dominique A Cadilhac, Elizabeth McInnes, Rosemary Phillips, Simeon Dale, Denise O'Connor, Chris Levi, Mark Fitzgerald, Julie Considine, Jeremy M Grimshaw, Richard Gerraty, N Wah Cheung, Jeanette Ward, Sandy Middleton
BACKGROUND: Theoretical frameworks and models based on behaviour change theories are increasingly used in the development of implementation interventions. Development of an implementation intervention is often based on the available evidence base and practical issues, i.e. feasibility and acceptability. The aim of this study was to describe the development of an implementation intervention for the T(3) Trial (Triage, Treatment and Transfer of patients with stroke in emergency departments (EDs)) using theory to recommend behaviour change techniques (BCTs) and drawing on the research evidence base and practical issues of feasibility and acceptability...
July 17, 2017: Implementation Science: IS
https://www.readbyqxmd.com/read/28707547/-we-need-a-safe-walkable-way-to-connect-our-sisters-and-brothers-a-qualitative-study-of-opportunities-and-challenges-for-neighborhood-based-physical-activity-among-residents-of-low-income-african-american-communities
#4
Stephanie T Child, Andrew T Kaczynski, Melissa L Fair, Ellen W Stowe, S Morgan Hughey, Lauren Boeckerman, Sally Wills, Yvonne Reeder
OBJECTIVE: The purpose of this study was to explore perceptions of the benefits of and influencing factors for neighborhood-based physical activity (PA), and elicit suggestions for increasing neighborhood-based PA among primarily Black residents living in lower income neighborhoods. DESIGN: Eight focus groups were conducted in low-income, predominantly Black neighborhoods (n = 8) in Greenville, SC during Spring 2014. Using a semi-structured focus group guide with open-ended questions, residents were asked to describe benefits of PA, neighborhood factors associated with PA, and ways to increase PA within their neighborhoods...
July 14, 2017: Ethnicity & Health
https://www.readbyqxmd.com/read/28702185/potential-cost-savings-by-minimisation-of-blood-sample-delays-on-care-decision-making-in-urgent-care-services
#5
David M S Bodansky, Sophie E Lumley, Rudrajoy Chakraborty, Dhanasekaran Mani, James Hodson, Mike T Hallissey, Olga N Tucker
BACKGROUND: Timely availability of blood sample results for interpretation affects planning and delivery of patient care from initial assessment in Accident and Emergency (A&E) departments. MATERIALS AND METHODS: Rates of, and reasons for, rejected blood samples submitted from all clinical areas over one month were evaluated. Haemoglobin (Hb) represented haematology and potassium (K(+)), biochemistry. A prospective observational study evaluated the methodology of sample collection and impact on utility...
August 2017: Annals of Medicine and Surgery
https://www.readbyqxmd.com/read/28699916/egfr-signaling-promotes-inflammation-and-cancer-stem-like-activity-in-inflammatory-breast-cancer
#6
Xiaoping Wang, Monica E Reyes, Dongwei Zhang, Yohei Funakoshi, Adriana P Trape, Yun Gong, Takahiro Kogawa, Bedrich L Eckhardt, Hiroko Masuda, David A Pirman, Peiying Yang, James M Reuben, Wendy A Woodward, Chandra Bartholomeusz, Gabriel N Hortobagyi, Debu Tripathy, Naoto T Ueno
Inflammatory breast cancer (IBC) is the most lethal and aggressive type of breast cancer, with a strong proclivity to metastasize, and IBC-specific targeted therapies have not yet been developed. Epidermal growth factor receptor (EGFR) has emerged as an important therapeutic target in IBC. However, the mechanism behind the therapeutic effect of EGFR targeted therapy is not well defined. Here, we report that EGFR regulates the IBC cell population that expresses cancer stem-like cell (CSC) markers through COX-2, a key mediator of inflammation whose expression correlates with worse outcome in IBC...
July 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28692873/evaluation-of-microencapsulation-of-the-ufv-areg1-bacteriophage-in-alginate-ca-microcapsules-using-microfluidic-devices
#7
Delaine M G Boggione, Laís S Batalha, Marco T P Gontijo, Maryoris E S Lopez, Alvaro V N C Teixeira, Igor J B Santos, Regina C S Mendonça
The indiscriminate use of antibiotics and the emergence of resistant microorganisms have become a major challenge for the food industry. The purpose of this work was to microencapsulate the bacteriophage UFV-AREG1 in a calcium alginate matrix using microfluidic devices and to study the viability and efficiency of retention. The microcapsules were added to gel of propylene glycol for use as an antimicrobial in the food industry. The technique showed the number of the phage encapsulation, yielding drops with an average 100-250μm of diameter, 82...
June 28, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28688830/differential-effects-of-renal-denervation-on-arterial-baroreceptor-function-in-goldblatt-hypertension-model
#8
Gisele S Lincevicius, Caroline G Shimoura, Erika E Nishi, Tales Oliveira, Juliana G Cespedes, Cássia T Bergamaschi, Ruy R Campos
Sympathetic vasomotor activity is significantly increased in renovascular hypertension. Renal denervation (DnX) has emerged as a novel therapy for resistant hypertension to drug therapy. However, the underlying mechanisms regarding the reduction in blood pressure (BP) after DnX remain unclear. Thus, the aim of this study was to evaluate the effects of DnX of a clipped kidney on the baseline and baroreceptor reflex control of post-ganglionic sympathetic activity to the contralateral kidney (rSNA) and lumbar (lSNA) nerves in Goldblatt hypertensive rats (2K1C)...
June 21, 2017: Autonomic Neuroscience: Basic & Clinical
https://www.readbyqxmd.com/read/28682130/the-front-line-general-surgery-consultant-as-a-new-model-of-emergency-care
#9
A P Navarro, Ejo Hardy, B Oakley, E Mohamed, N T Welch, S L Parsons
INTRODUCTION Emergency general surgery services in England are undergoing rapid structural change with the aim of improving care. In our centre, the key issues identified were high numbers of admissions, inappropriate referrals, prolonged waiting times, delayed senior input and poor patient satisfaction. A new model was launched in January 2015 to address these issues: the surgical triage unit (STU). This study assesses the success of the new service. METHODS All emergency general surgical admissions during a five-month period before introduction of the STU were compared with those of a comparable five-month period after its introduction...
July 6, 2017: Annals of the Royal College of Surgeons of England
https://www.readbyqxmd.com/read/28653327/are-severely-injured-trauma-victims-in-norway-offered-advanced-pre-hospital-care-national-retrospective-observational-cohort
#10
T Wisborg, E N Ellensen, I Svege, T Dehli
BACKGROUND: Studies of severely injured patients suggest that advanced pre-hospital care and/or rapid transportation provides a survival benefit. This benefit depends on the disposition of resources to patients with the greatest need. Norway has 19 Emergency Helicopters (HEMS) staffed by anaesthesiologists on duty 24/7/365. National regulations describe indications for their use, and the use of the national emergency medical dispatch guideline is recommended. We assessed whether severely injured patients had been treated or transported by advanced resources on a national scale...
June 26, 2017: Acta Anaesthesiologica Scandinavica
https://www.readbyqxmd.com/read/28651047/prioritization-of-contaminants-of-emerging-concern-in-wastewater-treatment-plant-discharges-using-chemical-gene-interactions-in-caged-fish
#11
Edward J Perkins, Tanwir Habib, Barbara L Escalon, Jenna E Cavallin, Linnea Thomas, Matthew Weberg, Megan N Hughes, Kathleen M Jensen, Michael D Kahl, Daniel L Villeneuve, Gerald T Ankley, Natalia Garcia-Reyero
We examined whether contaminants present in surface waters could be prioritized for further assessment by linking the presence of specific chemicals to gene expression changes in exposed fish. Fathead minnows were deployed in cages for 2, 4, or 8 days at three locations near two different wastewater treatment plant discharge sites in the Saint Louis Bay, Duluth, MN and one upstream reference site. The biological impact of 51 chemicals detected in the surface water of 133 targeted chemicals was determined using biochemical endpoints, exposure activity ratios for biological and estrogenic responses, known chemical:gene interactions from biological pathways and knowledge bases, and analysis of the co-variance of ovary gene expression with surface water chemistry...
June 26, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28647681/daily-associations-between-cannabis-motives-and-consumption-in-emerging-adults
#12
Erin E Bonar, Jason E Goldstick, R Lorraine Collins, James A Cranford, Rebecca M Cunningham, Stephen T Chermack, Frederic C Blow, Maureen A Walton
BACKGROUND: Increasing rates of cannabis use among emerging adults is a growing public health problem. Intensive longitudinal data can provide information on proximal motives for cannabis use, which can inform interventions to reduce use among emerging adults. METHOD: As part of a larger longitudinal study, patients aged 18-25 years (N=95) recruited from an urban Emergency Department completed daily text message assessments of risk behaviors for 28days, including daily cannabis quantity and motives...
June 15, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/28644774/cd33-splicing-polymorphism-determines-gemtuzumab-ozogamicin-response-in-de-novo-acute-myeloid-leukemia-report-from-randomized-phase-iii-children-s-oncology-group-trial-aaml0531
#13
Jatinder K Lamba, Lata Chauhan, Miyoung Shin, Michael R Loken, Jessica A Pollard, Yi-Cheng Wang, Rhonda E Ries, Richard Aplenc, Betsy A Hirsch, Susana C Raimondi, Roland B Walter, Irwin D Bernstein, Alan S Gamis, Todd A Alonzo, Soheil Meshinchi
Purpose Gemtuzumab ozogamicin (GO), a CD33-targeted immunoconjugate, is a re-emerging therapy for acute myeloid leukemia (AML). CD33 single nucleotide polymorphism rs12459419 C>T in the splice enhancer region regulates the expression of an alternatively spliced CD33 isoform lacking exon2 (D2-CD33), thus eliminating the CD33 IgV domain, which is the antibody-binding site for GO, as well as diagnostic immunophenotypic panels. We aimed to determine the impact of the genotype of this splicing polymorphism in patients with AML treated with GO-containing chemotherapy...
June 23, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28642024/rtms-with-a-two-coil-array-safety-and-efficacy-for-treatment-resistant-major-depressive-disorder
#14
Linda L Carpenter, Scott T Aaronson, Gregory N Clarke, Paul E Holtzheimer, Clark W Johnson, William M McDonald, Elizabeth L Stannard, M Bret Schneider
BACKGROUND: Therapeutic repetitive Transcranial Magnetic Stimulation (rTMS) has emerged as a standard of care for individuals with major depressive disorder (MDD) who do not benefit from, or are unable to tolerate, antidepressant pharmacotherapy. Depth of stimulation is limited with currently approved figure-eight coils and larger coils capable of deeper penetration may be associated with loss of stimulation focality and undesired recruitment of motor cortex. A second generation 2-coil array rTMS system was designed to target converging brain pathways for potentially deeper prefrontal cortex stimulation...
June 9, 2017: Brain Stimulation
https://www.readbyqxmd.com/read/28638489/harnessing-integrative-omics-to-facilitate-molecular-imaging-of-the-human-epidermal-growth-factor-receptor-family-for-precision-medicine
#15
REVIEW
Martin Pool, H Rudolf de Boer, Marjolijn N Lub-de Hooge, Marcel A T M van Vugt, Elisabeth G E de Vries
Cancer is a growing problem worldwide. The cause of death in cancer patients is often due to treatment-resistant metastatic disease. Many molecularly targeted anticancer drugs have been developed against 'oncogenic driver' pathways. However, these treatments are usually only effective in properly selected patients. Resistance to molecularly targeted drugs through selective pressure on acquired mutations or molecular rewiring can hinder their effectiveness. This review summarizes how molecular imaging techniques can potentially facilitate the optimal implementation of targeted agents...
2017: Theranostics
https://www.readbyqxmd.com/read/28630705/physiological-effects-of-stress-related-to-helicopter-travel-in-federal-emergency-management-agency-search-and-rescue-canines
#16
E Perry, N Gulson, T-W Liu Cross, K S Swanson
Working canines are deployed by the Federal Emergency Management Agency (FEMA), as part of a National Disaster Response Plan. Stress associated with helicopter flight and the resulting physical effects on the dog are unknown. Our objective was to test the hypotheses that (1) helicopter travel affects the physiology and faecal microbiota of working canines, but that (2) physiological consequences of helicopter travel will not negatively affect their work performance. A total of nine FEMA canines were loaded onto helicopters and flown for 30 min in July 2015...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28630453/longitudinal-analyses-of-the-dna-methylome-in-deployed-military-servicemen-identify-susceptibility-loci-for-post-traumatic-stress-disorder
#17
B P F Rutten, E Vermetten, C H Vinkers, G Ursini, N P Daskalakis, E Pishva, L de Nijs, L C Houtepen, L Eijssen, A E Jaffe, G Kenis, W Viechtbauer, D van den Hove, K G Schraut, K-P Lesch, J E Kleinman, T M Hyde, D R Weinberger, L Schalkwyk, K Lunnon, J Mill, H Cohen, R Yehuda, D G Baker, A X Maihofer, C M Nievergelt, E Geuze, M P M Boks
In order to determine the impact of the epigenetic response to traumatic stress on post-traumatic stress disorder (PTSD), this study examined longitudinal changes of genome-wide blood DNA methylation profiles in relation to the development of PTSD symptoms in two prospective military cohorts (one discovery and one replication data set). In the first cohort consisting of male Dutch military servicemen (n=93), the emergence of PTSD symptoms over a deployment period to a combat zone was significantly associated with alterations in DNA methylation levels at 17 genomic positions and 12 genomic regions...
June 20, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28617822/intronic-snp-in-esr1-encoding-human-estrogen-receptor-alpha-is-associated-with-brain-esr1-mrna-isoform-expression-and-behavioral-traits
#18
Julia K Pinsonneault, John T Frater, Benjamin Kompa, Roshan Mascarenhas, Danxin Wang, Wolfgang Sadee
Genetic variants of ESR1 have been implicated in multiple diseases, including behavioral disorders, but causative variants remain uncertain. We have searched for regulatory variants affecting ESR1 expression in human brain, measuring allelic ESR1 mRNA expression in human brain tissues with marker SNPs in exon4 representing ESR1-008 (or ESRα-36), and in the 3'UTR of ESR1-203, two main ESR1 isoforms in brain. In prefrontal cortex from subjects with bipolar disorder, schizophrenia, and controls (n = 35 each; Stanley Foundation brain bank), allelic ESR1 mRNA ratios deviated from unity up to tenfold at the exon4 marker SNP, with large allelic ratios observed primarily in bipolar and schizophrenic subjects...
2017: PloS One
https://www.readbyqxmd.com/read/28599207/mercury-and-persistent-organic-pollutants-in-native-and-invading-forage-species-of-the-canadian-arctic-consequences-for-food-web-dynamics
#19
Sara Pedro, Aaron T Fisk, Gregg T Tomy, Steven H Ferguson, Nigel E Hussey, Steven T Kessel, Melissa A McKinney
Contaminant dynamics within Arctic marine food webs may be altered through the climate-driven northward invasions of temperate/boreal species. Here, we compare tissue concentrations of total mercury (THg) and legacy and emerging persistent organic pollutants (POPs) in native versus invading forage species sampled from 2012 to 2014 near Arviat, Clyde River, and Resolute Bay, NU, representing, low, mid- and high eastern Canadian Arctic regions, respectively. Concentrations of THg, legacy Σ-polychlorinated biphenyls (ΣPCB) and Σ-organochlorine (ΣOC) pesticides were detected in all forage species, whereas emerging halogenated flame retardants were detected in only a few individuals...
June 6, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28598034/hepatitis-e-in-southern-vietnam-seroepidemiology-in-humans-and-molecular-epidemiology-in-pigs
#20
A Berto, H A Pham, T T N Thao, N H T Vy, S L Caddy, R Hiraide, N T Tue, I Goodfellow, J J Carrique-Mas, G E Thwaites, S Baker, M F Boni
Viral pathogens account for a significant proportion of the burden of emerging infectious diseases in humans. The Wellcome Trust-Vietnamese Initiative on Zoonotic Infections (WT-VIZIONS) is aiming to understand the circulation of viral zoonotic pathogens in animals that pose a potential risk to human health. Evidence suggests that human exposure and infections with hepatitis E virus (HEV) genotypes (GT) 3 and 4 results from zoonotic transmission. Hypothesising that HEV GT3 and GT4 are circulating in the Vietnamese pig population and can be transmitted to humans, we aimed to estimate the seroprevalence of HEV exposure in a population of farmers and the general population...
June 9, 2017: Zoonoses and Public Health
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