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Deep mycosis

José F Muñoz, Rhys A Farrer, Christopher A Desjardins, Juan E Gallo, Sean Sykes, Sharadha Sakthikumar, Elizabeth Misas, Emily A Whiston, Eduardo Bagagli, Celia M A Soares, Marcus de M Teixeira, John W Taylor, Oliver K Clay, Juan G McEwen, Christina A Cuomo
The Paracoccidioides genus includes two species of thermally dimorphic fungi that cause paracoccidioidomycosis, a neglected health-threatening human systemic mycosis endemic to Latin America. To examine the genome evolution and the diversity of Paracoccidioides spp., we conducted whole-genome sequencing of 31 isolates representing the phylogenetic, geographic, and ecological breadth of the genus. These samples included clinical, environmental and laboratory reference strains of the S1, PS2, PS3, and PS4 lineages of P...
September 2016: MSphere
Marcus de M Teixeira, José S L Patané, Maria L Taylor, Beatriz L Gómez, Raquel C Theodoro, Sybren de Hoog, David M Engelthaler, Rosely M Zancopé-Oliveira, Maria S S Felipe, Bridget M Barker
BACKGROUND: Histoplasma capsulatum comprises a worldwide complex of saprobiotic fungi mainly found in nitrogen/phosphate (often bird guano) enriched soils. The microconidia of Histoplasma species may be inhaled by mammalian hosts, and is followed by a rapid conversion to yeast that can persist in host tissues causing histoplasmosis, a deep pulmonary/systemic mycosis. Histoplasma capsulatum sensu lato is a complex of at least eight clades geographically distributed as follows: Australia, Netherlands, Eurasia, North American classes 1 and 2 (NAm 1 and NAm 2), Latin American groups A and B (LAm A and LAm B) and Africa...
June 2016: PLoS Neglected Tropical Diseases
B Pilmis, A Puel, O Lortholary, F Lanternier
Incidence of invasive fungal infections increases over time with the rise in at-risk populations; in particular, patients with acquired immunodeficiencies due to immunosuppressive therapies such as anti-tumour necrosis factor-α (TNF-α) treatment, cirrhosis or burns. Some primary immunodeficiencies (PID) can also predispose selectively to invasive fungal diseases. Conversely, some atypical fungal diseases can reveal new PID. Deep dermatophytosis, Candida central nervous system infections or gastrointestinal disease, or disseminated phaeohyphomycosis-revealed CARD9 deficiency...
August 2016: Clinical Microbiology and Infection
Alireza Abdolrasouli, Ximena Gonzalo, Anita Jatan, Gordon J McArthur, Nicholas Francis, Berge S Azadian, Andrew M Borman, Elizabeth M Johnson
An 88-year-old man, receiving prednisolone for sarcoidosis, presented with a discrete keratotic lesion on the dorsum of his right hand following the placement of an intravenous cannula a month prior to its appearance. Medicopsis romeroi was isolated from the tissue and identified by sequencing the internal transcribed spacer region ITS-1 and the D1-2 fragment of the 28S rDNA gene. Histopathological examination showed fungal hyphae in the internal inflammatory cells layer and within the histocyte-macrophage layer, highly suggestive of deep mycosis...
October 2016: Mycopathologia
A H Verma, C L Bueter, M E Rothenberg, G S Deepe
Eosinophils contribute to type II immune responses in helminth infections and allergic diseases; however, their influence on intracellular pathogens is less clear. We previously reported that CCR2(-/-) mice exposed to the intracellular fungal pathogen Histoplasma capsulatum exhibit dampened immunity caused by an early exaggerated interleukin (IL)-4 response. We sought to identify the cellular source promulgating IL-4 in infected mutant animals. Eosinophils were the principal instigators of non-protective IL-4 and depleting this granulocyte population improved fungal clearance in CCR2(-/-) animals...
April 6, 2016: Mucosal Immunology
Hiroshige Mikamo
No abstract text is available yet for this article.
2016: Medical Mycology Journal
Luciana Depiere Lanzarin, Livia Caroline Barbosa Mariano, Maria Cristina Martins de Almeida Macedo, Marjorie Vieira Batista, Amaro Nunes Duarte
Aspergillosis is a mycosis that afflicts immunocompetent and immunocompromised hosts; among the former it exhibits different clinical pictures, and among the latter the infection renders an invasive form of the disease. The histologic diagnosis of invasive aspergillosis is somewhat challenging mostly because of some morphological similarities between other fungi. However, when present, the conidial heads are pathognomonic of aspergillosis. The authors present the case of a 68-year-old woman who was submitted to autologous hematopoietic stem cell transplantation in the pursuit of multiple myeloma treatment...
October 2015: Autopsy & case reports
Atiyah Patel, Victor Mudenda, Shabir Lakhi, Owen Ngalamika
Sporotrichosis is a subacute or chronic granulomatous mycosis caused by fungus of the Sporothrix schenckii complex. It is considered to be a rare condition in most parts of the world. It mostly causes cutaneous infection but can also cause multisystemic disease. Unlike most deep cutaneous mycoses which have a primary pulmonary focus, it is usually caused by direct inoculation of the fungus into the skin causing a classical linear, lymphocutaneous nodular eruption. However, atypical presentations of the condition can occur especially in immunosuppressed individuals...
2016: Case Reports in Dermatological Medicine
Wesley J Woollard, Nithyha P Kalaivani, Christine L Jones, Catherine Roper, Lam Tung, Jae Jin Lee, Bjorn R Thomas, Isabella Tosi, Silvia Ferreira, Carl Z Beyers, Robert C T McKenzie, Rosie M Butler, Anna Lorenc, Sean J Whittaker, Tracey J Mitchell
Methylthioadenosine phosphorylase (MTAP) and the tumor suppressor genes CDKN2A-CDKN2B are frequently deleted in malignancies. The specific role of MTAP in cutaneous T-cell lymphoma subgroups, mycosis fungoides (MF) and Sézary syndrome (SS), is unknown. In 213 skin samples from patients with MF/SS, MTAP copy number loss (34%) was more frequent than CDKN2A (12%) in all cutaneous T-cell lymphoma stages using quantitative reverse transcription PCR. Importantly, in early stage MF, MTAP loss occurred independently of CDKN2A loss in 37% of samples...
June 2016: Journal of Investigative Dermatology
Takashi Yaguchi
No abstract text is available yet for this article.
2015: Medical Mycology Journal
Elis Araujo Morais, Daniela Ferreira Chame, Eliza Mathias Melo, Junnia Alvarenga de Carvalho Oliveira, Ana Cláudia Chagas de Paula, Andiara Cardoso Peixoto, Lílian da Silva Santos, Dawidson Assis Gomes, Remo Castro Russo, Alfredo Miranda de Goes
Paracoccidioidomycosis is caused by fungi of the Paracoccidioides genus and constitutes the most prevalent deep mycosis in Latin America. Toll-like receptors promote immune response against infectious agents. Recently, it was reported that TLR9 is crucial for mice survival during the first 48 h of P. brasiliensis infection. In this study, we used CPG oligodeoxynucleotide motif as an adjuvant with and without rPb27 to immunize mice against Paracoccidioidomycosis. CPG adjuvant induced differential recruitment of lymphocytes in the inflammatory process and a lower recruitment of neutrophils...
February 2016: Microbes and Infection
Alexandro Bonifaz, Diana Morales, Neredi Morales, Patricia Mercadillo, Gloria M González, Francisca Hernández-Hernández, Javier Araiza, Denisse Vázquez-González
BACKGROUND: Blastomycosis is a subacute or chronic deep mycosis caused by a dimorphic fungus called Blastomyces dermatitidis, which generally produces a pulmonary form of the disease and, to a lesser extent, extra-pulmonary forms such as cutaneous, osteoarticular and genitourinary, among others. Cutaneous blastomycosis is the second clinical presentation in frequency. It is considered as primary when it begins by inoculation of the fungus due to traumas, and secondary when the lung fails to contain the infection...
January 2016: Revista Iberoamericana de Micología
Karine Ortiz Sanchotene, Isabel Martins Madrid, Gabriel Baracy Klafke, Mariana Bergamashi, Paula Portella Della Terra, Anderson Messias Rodrigues, Zoilo Pires de Camargo, Melissa Orzechowski Xavier
Sporotrichosis is the main subcutaneous mycosis in Brazil, and is caused by Sporothrix schenckii and allied species. Sporothrix propagules present on soil and plant debris may be traumatically inoculated into the cutaneous/ subcutaneous tissues of the warm-blooded host. An alternative route involves direct animal-animal and animal-human transmissions through deep scratches and bites of diseased cats. Sporotrichosis is much more common than previously appreciated with several cases emerging over the years especially in South and Southeast Brazil...
November 2015: Mycoses
Hitoshi Honda, Brian S Heist, Ken Kikuchi
No abstract text is available yet for this article.
2015: Medical Mycology Journal
Hitoshi Honda, Brian S Heist, Ken Kikuchi
No abstract text is available yet for this article.
2015: Medical Mycology Journal
Sombo Fwoloshi, Sharon Musonda Machona, Victor Mudenda, Owen Ngalamika
Leprosy is a granulomatous disease that mainly affects the skin and peripheral nerves. It is caused by infection with mycobacterium leprae or mycobacterium lepromatosus. In most instances, diagnosis of leprosy can easily be made based on the clinical signs and symptoms. However, when patients present with atypical features, clinical diagnosis can be a challenge. We report a case of a nursing mother with lepromatous leprosy who presented with dysphonia and skin lesions initially thought to be a deep cutaneous mycosis...
2015: Pan African Medical Journal
Ramesh M Bhat, Rochelle C Monteiro, Nandakishore Bala, Sukumar Dandakeri, Jacintha Martis, Ganesh H Kamath, Srinath M Kambil, Ramay Asha Vadakayil
BACKGROUND: Subcutaneous mycoses are chronic, localized infections of the skin and subcutaneous tissue which occur following traumatic implantation of the etiological agent. The causative organisms are soil saprophytes of regional epidemiology with varying ability to adapt to the tissue environment and elicit disease. OBJECTIVES: This study was conducted to evaluate the various types of subcutaneous mycoses, including actinomycotic mycetomas, in south coastal Karnataka, India...
January 2016: International Journal of Dermatology
Madeleine Duvic, Michael T Tetzlaff, Pamela Gangar, Audra L Clos, Dawen Sui, Rakhshandra Talpur
PURPOSE: Brentuximab vedotin, a monoclonal antibody (cAC10) conjugated to monomethyl auristatin E, targets CD30(+) receptors. This phase II open-label trial was conducted to evaluate safety and efficacy in CD30(+) cutaneous T-cell lymphomas. PATIENTS AND METHODS: Forty-eight patients with CD30(+) lymphoproliferative disorders or mycosis fungoides (MF) received an infusion of 1.8 mg/kg every 21 days. RESULTS: Forty-eight evaluable patients (22 women and 26 men; median age, 59...
November 10, 2015: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
A Salami, C Assouan, M Kouyaté, A Kadre, N Yavo-Dosso, N D N'Guessan
INTRODUCTION: Mucormycosis is a deep mycosis which has been spreading out in recent years. It is still poorly understood and poorly described in sub-Saharan Africa. The authors report a case of sinonasal localization, of fatal evolution and late diagnosis in a young child. OBSERVATION: It is about a 13-year-old child suffering from chronic rhinosinus syndrome for two years. He was observed in stomatology for a necrotic velar ulceration that have occurred for three months...
September 2015: Journal de Mycologie Médicale
Guillaume Béraud, Nicole Desbois, Caroline Coyo, Danièle Quist, Benoit Rozé, Luc Savorit, André Cabié
Mycetoma is a chronic granulomatous infection that is difficult to treat, notably when due to fungi such as Scedosporium apiospermum. Recent antifungal agents could be an option, but cases are rarely reported, and none with posaconazole. Paradoxical responses, defined as initial clinical worsening despite appropriate treatment, are common in tuberculosis but rare in deep mycoses in non-immunocompromised hosts. Hence, paradoxical responses in context other than mycobacterial infection in an immunocompromised host could provide insights into the pathophysiology and the optimal strategy for treatment...
2015: Infectious Diseases
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