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Deep mycosis

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https://www.readbyqxmd.com/read/29128259/role-of-dysregulated-cytokine-signaling-and-bacterial-triggers-in-the-pathogenesis-of-cutaneous-t-cell-lymphoma
#1
Melania H Fanok, Amy Sun, Laura K Fogli, Vijay Narendran, Miriam Eckstein, Kasthuri Kannan, Igor Dolgalev, Charalampos Lazaris, Adriana Heguy, Mary E Laird, Mark S Sundrud, Cynthia Liu, Jeff Kutok, Rodrigo S Lacruz, Jo-Ann Latkowski, Iannis Aifantis, Niels Ødum, Kenneth B Hymes, Swati Goel, Sergei B Koralov
Cutaneous T cell lymphoma is a heterogeneous group of lymphomas characterized by the accumulation of malignant T cells in the skin. The molecular and cellular etiology of this malignancy remains enigmatic and what role antigenic stimulation plays in the initiation and/or progression of the disease remains to be elucidated. Deep sequencing of the tumor genome revealed a highly heterogeneous landscape of genetic perturbations and transcriptome analysis of transformed T cells further highlighted the heterogeneity of this disease...
November 8, 2017: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/29082569/deep-facial-mycosis-due-to-trichophyton-verrucosum-molecular-genetic-identification-of-the-dermatophyte-in-paraffin-embedded-tissue-case-report-and-review-of-the-literature
#2
REVIEW
U Wollina, G Hansel, S Uhrlaß, C Krüger, J Schönlebe, U-C Hipler, P Nenoff
Deep trichophytosis is relatively uncommon. The infection of the bearded area is also known as sycosis barbae or tinea barbae and can be caused by various fungal species, most often zoophilic fungi. We report on an 80-year-old male patient with severe sycosis barbae who had no animal contact and was treated with systemic antibiosis without improvement. Microbial and mycological investigations using swabs from oozing lesions revealed Staphylococcus hemolyticus and Candida parapsilosis. Histology demonstrated fungal elements in hair follicles...
October 30, 2017: Mycoses
https://www.readbyqxmd.com/read/29033820/pachyderma-in-primary-cutaneous-nk-and-t-cell-lymphoma-and-leukemia-cutis
#3
Eve Lebas, Cesar Chian, Nazli Nikkels-Tassoudji, Jorge E Arrese, Arjen F Nikkels
BACKGROUND: Pachyderma is defined as severely thickened skin with deep folds and is occasionally observed with primary cutaneous NK and T-cell lymphoma (pCNKTCL), primary cutaneous B-cell lymphoma (pCBCL), and leukemia cutis (LC). AIM: To describe the clinical, histological, and therapeutic particularities of a series of pCNKTCL, pCBCL, and LC patients with pachyderma. RESULTS: In a series of pCNKTCL (n = 70), pCBCL (n = 12), and LC (n = 2) patients followed up during 9 years, 6 cases of pachyderma were observed...
September 2017: Case Reports in Dermatology
https://www.readbyqxmd.com/read/28855485/potential-of-next-generation-poct-in-infectious-disease-rapid-test
#4
Naoto Shimetani
Real-time test results are necessary for early diagnosis and in determining treatment orientation in medical practice. Point of Care Testing (POCT) is a testing system that provides beneficial and helpful information for diagnosis and treatment through real-time testing at the bedside. Therefore, POCT has high utility value in the field of infectious diseases as a rapid test that provides, within the consultation hours, useful information for initial treatment.Infectious disease rapid test kits are commercially available for a wide variety of prophlogistic pathogen targets, including bacterial, viral, fungal, protozoal, and other disease agents...
2017: Medical Mycology Journal
https://www.readbyqxmd.com/read/28720727/impact-of-paracoccin-gene-silencing-on-paracoccidioides-brasiliensis-virulence
#5
Fabrício F Fernandes, Aline F Oliveira, Taise N Landgraf, Cristina Cunha, Agostinho Carvalho, Patrícia E Vendruscolo, Relber A Gonçales, Fausto Almeida, Thiago A da Silva, Fernando Rodrigues, Maria Cristina Roque-Barreira
Among the endemic deep mycoses in Latin America, paracoccidioidomycosis (PCM), caused by thermodimorphic fungi of the Paracoccidioides genus, is a major cause of morbidity. Disease development and its manifestations are associated with both host and fungal factors. Concerning the latter, several recent studies have employed the methodology of gene modulation in P. brasiliensis using antisense RNA (AsRNA) and Agrobacterium tumefaciens-mediated transformation (ATMT) to identify proteins that influence fungus virulence...
July 18, 2017: MBio
https://www.readbyqxmd.com/read/28600728/the-critical-role-of-notch1-tlr-4-signaling-in-the-inflammatory-and-fungicidal-activity-of-macrophages-against-paracoccidioides-brasiliensis-strain-pb18
#6
Lavínia Maria Dal'Mas Romera, Gilberto Hideo Kaihami, Grasielle Pereira Jannuzzi, José Roberto Fogaça de Almeida, Sandro Rogério de Almeida
Paracoccidioidomycosis is a systemic mycosis of deep nature that primarily affects the lung and can spread via lymphatic and hematogenous to other organs and tissues. It is mainly caused by Paracoccidioides brasiliensis fungus which exhibits thermal dimorphism. The innate immune system mediated by macrophages is extremely important for the control of infection and is involved in the induction and regulation of immune/inflammatory response. These cells are able to recognize pathogens through pattern recognition receptors (PRRs) such as Toll-like receptors (TLR)...
June 9, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28526427/atypical-presentations-of-cutaneous-leishmaniasis-a-systematic-review
#7
REVIEW
Camilla Barros Meireles, Laís Chaves Maia, Gustavo Coelho Soares, Ilara Parente Pinheiro Teodoro, Maria do Socorro Vieira Gadelha, Cláudio Gleidiston Lima da Silva, Marcos Antonio Pereira de Lima
Cutaneous Leishmaniasis (CL) is endemic in 88 countries, showing relevant prevalences. The aim of this study was to perform a systematic review on atypical lesions of CL around the world, addressing clinico-epidemiological, immunological and therapeutic aspects. A search of the literature was conducted via electronic databases Scopus and PubMed for articles published between 2010 and 2015. The search terms browsed were "cutaneous leishmaniasis", "atypical" and "unusual". Based on the eligibility criteria, 34 out of 122 articles were included in the final sample...
August 2017: Acta Tropica
https://www.readbyqxmd.com/read/28004227/trichophyton-rubrum-infection-characterized-by-majocchi-s-granuloma-and-deeper-dermatophytosis-case-report-and-review-of-published-literature
#8
Huilin Su, Li Li, Benlin Cheng, Junhao Zhu, Qiangqiang Zhang, Jinhua Xu, Min Zhu
Infections caused by Trichophyton rubrum are very common in dermatological disease. It most often appears as superficial cutaneous mycosis, such as tinea manuum, tinea pedis, and tinea corporis. However, deep infection caused by T. rubrum was rarely reported. We describe a case of mixed type of deep infection caused by T. rubrum in a 45-year-old man with no significant immunodeficiency. This patient had a history of onychomycosis on the toenails without regular treatment for nearly 6 years. And, he had erythema, papule, and nodules on the submandibular area, neck, and chest for almost 1 year...
June 2017: Mycopathologia
https://www.readbyqxmd.com/read/27904060/causative-agents-of-aspergillosis-including-cryptic-aspergillus-species-and-a-fumigatus
#9
REVIEW
Takahito Toyotome
Aspergillosis is an important deep mycosis. The causative agents are Aspergillus fumigatus, Aspergillus flavus, Aspergillus niger, and Aspergillus terreus, of which A. fumigatus is the most prevalent. Cryptic Aspergillus spp., which morphologically resemble representative species of each Aspergillus section, also cause aspergillosis. Most of the cryptic species reveal different susceptibility patterns and/or different secondary metabolite profiles, also called exometabolome in this manuscript, from those representative species...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27904053/executive-summary-of-japanese-domestic-guidelines-for-management-of-deep-seated-mycosis-2014
#10
REVIEW
Shigeru Kohno, Kazuo Tamura, Yoshihito Niki, Koichi Izumikawa, Shinichi Oka, Kenji Ogawa, Junichi Kadota, Katsuhiko Kamei, Yoshinobu Kanda, Tetsuya Kiuchi, Kazutoshi Shibuya, Syunji Takakura, Toru Takata, Yoshio Takesue, Katsuji Teruya, Issei Tokimatsu, Takahiro Fukuda, Shigefumi Maesaki, Koichi Makimura, Hiroshige Mikamo, Kotaro Mitsutake, Yoshitsugu Miyazaki, Masaaki Mori, Akira Yasuoka, Keiko Yano, Noboru Yamanaka, Minoru Yoshida
No abstract text is available yet for this article.
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27704050/genome-diversity-recombination-and-virulence-across-the-major-lineages-of-paracoccidioides
#11
José F Muñoz, Rhys A Farrer, Christopher A Desjardins, Juan E Gallo, Sean Sykes, Sharadha Sakthikumar, Elizabeth Misas, Emily A Whiston, Eduardo Bagagli, Celia M A Soares, Marcus de M Teixeira, John W Taylor, Oliver K Clay, Juan G McEwen, Christina A Cuomo
The Paracoccidioides genus includes two species of thermally dimorphic fungi that cause paracoccidioidomycosis, a neglected health-threatening human systemic mycosis endemic to Latin America. To examine the genome evolution and the diversity of Paracoccidioides spp., we conducted whole-genome sequencing of 31 isolates representing the phylogenetic, geographic, and ecological breadth of the genus. These samples included clinical, environmental and laboratory reference strains of the S1, PS2, PS3, and PS4 lineages of P...
September 2016: MSphere
https://www.readbyqxmd.com/read/27248851/worldwide-phylogenetic-distributions-and-population-dynamics-of-the-genus-histoplasma
#12
Marcus de M Teixeira, José S L Patané, Maria L Taylor, Beatriz L Gómez, Raquel C Theodoro, Sybren de Hoog, David M Engelthaler, Rosely M Zancopé-Oliveira, Maria S S Felipe, Bridget M Barker
BACKGROUND: Histoplasma capsulatum comprises a worldwide complex of saprobiotic fungi mainly found in nitrogen/phosphate (often bird guano) enriched soils. The microconidia of Histoplasma species may be inhaled by mammalian hosts, and is followed by a rapid conversion to yeast that can persist in host tissues causing histoplasmosis, a deep pulmonary/systemic mycosis. Histoplasma capsulatum sensu lato is a complex of at least eight clades geographically distributed as follows: Australia, Netherlands, Eurasia, North American classes 1 and 2 (NAm 1 and NAm 2), Latin American groups A and B (LAm A and LAm B) and Africa...
June 2016: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/27237547/new-clinical-phenotypes-of-fungal-infections-in-special-hosts
#13
REVIEW
B Pilmis, A Puel, O Lortholary, F Lanternier
Incidence of invasive fungal infections increases over time with the rise in at-risk populations; in particular, patients with acquired immunodeficiencies due to immunosuppressive therapies such as anti-tumour necrosis factor-α (TNF-α) treatment, cirrhosis or burns. Some primary immunodeficiencies (PID) can also predispose selectively to invasive fungal diseases. Conversely, some atypical fungal diseases can reveal new PID. Deep dermatophytosis, Candida central nervous system infections or gastrointestinal disease, or disseminated phaeohyphomycosis-revealed CARD9 deficiency...
August 2016: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/27193294/subcutaneous-phaeohyphomycosis-cyst-associated-with-medicopsis-romeroi-in-an-immunocompromised-host
#14
Alireza Abdolrasouli, Ximena Gonzalo, Anita Jatan, Gordon J McArthur, Nicholas Francis, Berge S Azadian, Andrew M Borman, Elizabeth M Johnson
An 88-year-old man, receiving prednisolone for sarcoidosis, presented with a discrete keratotic lesion on the dorsum of his right hand following the placement of an intravenous cannula a month prior to its appearance. Medicopsis romeroi was isolated from the tissue and identified by sequencing the internal transcribed spacer region ITS-1 and the D1-2 fragment of the 28S rDNA gene. Histopathological examination showed fungal hyphae in the internal inflammatory cells layer and within the histocyte-macrophage layer, highly suggestive of deep mycosis...
October 2016: Mycopathologia
https://www.readbyqxmd.com/read/27049063/eosinophils-subvert-host-resistance-to-an-intracellular-pathogen-by-instigating-non-protective-il-4-in-ccr2-mice
#15
A H Verma, C L Bueter, M E Rothenberg, G S Deepe
Eosinophils contribute to type II immune responses in helminth infections and allergic diseases; however, their influence on intracellular pathogens is less clear. We previously reported that CCR2(-/-) mice exposed to the intracellular fungal pathogen Histoplasma capsulatum exhibit dampened immunity caused by an early exaggerated interleukin (IL)-4 response. We sought to identify the cellular source promulgating IL-4 in infected mutant animals. Eosinophils were the principal instigators of non-protective IL-4 and depleting this granulocyte population improved fungal clearance in CCR2(-/-) animals...
January 2017: Mucosal Immunology
https://www.readbyqxmd.com/read/26936350/-deep-seated-mycosis
#16
Hiroshige Mikamo
No abstract text is available yet for this article.
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/26894041/conidial-heads-fruiting-bodies-as-a-hallmark-for-histopathological-diagnosis-of-angioinvasive-aspergillosis
#17
Luciana Depiere Lanzarin, Livia Caroline Barbosa Mariano, Maria Cristina Martins de Almeida Macedo, Marjorie Vieira Batista, Amaro Nunes Duarte
Aspergillosis is a mycosis that afflicts immunocompetent and immunocompromised hosts; among the former it exhibits different clinical pictures, and among the latter the infection renders an invasive form of the disease. The histologic diagnosis of invasive aspergillosis is somewhat challenging mostly because of some morphological similarities between other fungi. However, when present, the conidial heads are pathognomonic of aspergillosis. The authors present the case of a 68-year-old woman who was submitted to autologous hematopoietic stem cell transplantation in the pursuit of multiple myeloma treatment...
October 2015: Autopsy & case reports
https://www.readbyqxmd.com/read/26881148/a-27-year-old-severely-immunosuppressed-female-with-misleading-clinical-features-of-disseminated-cutaneous-sporotrichosis
#18
Atiyah Patel, Victor Mudenda, Shabir Lakhi, Owen Ngalamika
Sporotrichosis is a subacute or chronic granulomatous mycosis caused by fungus of the Sporothrix schenckii complex. It is considered to be a rare condition in most parts of the world. It mostly causes cutaneous infection but can also cause multisystemic disease. Unlike most deep cutaneous mycoses which have a primary pulmonary focus, it is usually caused by direct inoculation of the fungus into the skin causing a classical linear, lymphocutaneous nodular eruption. However, atypical presentations of the condition can occur especially in immunosuppressed individuals...
2016: Case Reports in Dermatological Medicine
https://www.readbyqxmd.com/read/26872600/independent-loss-of-methylthioadenosine-phosphorylase-mtap-in-primary-cutaneous-t-cell-lymphoma
#19
COMPARATIVE STUDY
Wesley J Woollard, Nithyha P Kalaivani, Christine L Jones, Catherine Roper, Lam Tung, Jae Jin Lee, Bjorn R Thomas, Isabella Tosi, Silvia Ferreira, Carl Z Beyers, Robert C T McKenzie, Rosie M Butler, Anna Lorenc, Sean J Whittaker, Tracey J Mitchell
Methylthioadenosine phosphorylase (MTAP) and the tumor suppressor genes CDKN2A-CDKN2B are frequently deleted in malignancies. The specific role of MTAP in cutaneous T-cell lymphoma subgroups, mycosis fungoides (MF) and Sézary syndrome (SS), is unknown. In 213 skin samples from patients with MF/SS, MTAP copy number loss (34%) was more frequent than CDKN2A (12%) in all cutaneous T-cell lymphoma stages using quantitative reverse transcription PCR. Importantly, in early stage MF, MTAP loss occurred independently of CDKN2A loss in 37% of samples...
June 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/26617110/deep-seated-mycosis-aspergillus-lentulus
#20
Takashi Yaguchi
No abstract text is available yet for this article.
2015: Medical Mycology Journal
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