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aseptic sterilization

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https://www.readbyqxmd.com/read/29710757/safety-evaluation-and-consideration-of-4-pin-multi-needle-for-meso-therapy
#1
Jun-Tae Kim, Ahnryul Choi, Jin-Hyoung Jeong, Jae-Hyun Jo, Ok-Su Ryu, Eun-Ji Kim, Ki-Young Kim, Mi-Hee Song, Young-Ho Song, Woon-Seob Shin, Sang-Sik Lee
In this study was conducted according to the method presented in the Republic of Korea Pharmacopoeia 11th Revision, aseptic test method to evaluate the suitability of sterilization for a sterile needle (4 Pin Multi-needle). In this study, four tests were conducted: sterility test, cytotoxicity test, acute toxicity test, skin sensitization test. First, in the aseptic test, the microorganism was not proliferated in the aseptic test of the medium. As a result of the performance test of the medium, it was confirmed that the microorganism developed within 3 days and the fungus was evident within 5 days...
April 17, 2018: Technology and Health Care: Official Journal of the European Society for Engineering and Medicine
https://www.readbyqxmd.com/read/29707402/molecularly-specific-detection-of-bacterial-lipoteichoic-acid-for-diagnosis-of-prosthetic-joint-infection-of-the-bone
#2
Julie E Pickett, John M Thompson, Agnieszka Sadowska, Christine Tkaczyk, Bret R Sellman, Andrea Minola, Davide Corti, Antonio Lanzavecchia, Lloyd S Miller, Daniel Lj Thorek
Discriminating sterile inflammation from infection, especially in cases of aseptic loosening versus an actual prosthetic joint infection, is challenging and has significant treatment implications. Our goal was to evaluate a novel human monoclonal antibody (mAb) probe directed against the Gram-positive bacterial surface molecule lipoteichoic acid (LTA). Specificity and affinity were assessed in vitro. We then radiolabeled the anti-LTA mAb and evaluated its effectiveness as a diagnostic imaging tool for detecting infection via immunoPET imaging in an in vivo mouse model of prosthetic joint infection (PJI)...
2018: Bone Research
https://www.readbyqxmd.com/read/29672240/national-survey-of-operating-room-nurses-aseptic-techniques-and-interventions-for-patient-preparation-to-reduce-surgical-site-infections
#3
Camilla Wistrand, Karin Falk-Brynhildsen, Ulrica Nilsson
BACKGROUND: Surgical site infection (SSI), the third most common type of nosocomial infection in Sweden, is a patient injury that should be prevented. Methods of reducing SSIs include, for instance, disinfecting the skin, maintaining body temperature, and ensuring an aseptic environment. Guidelines for most of these interventions exist, but there is a lack of studies describing to what extent the preventive interventions have been implemented in clinical practice. We describe the daily clinical interventions Swedish operating room (OR) nurses performed to prevent SSIs following national guidelines...
April 19, 2018: Surgical Infections
https://www.readbyqxmd.com/read/29659450/aseptic-freeze-dried-vs-sterile-wet-packaged-human-cadaveric-acellular-dermal-matrix-adm-in-immediate-tissue-expander-breast-reconstruction-a-propensity-score-analysis-study
#4
Summer E Hanson, Jesse D Meaike, Jesse C Selber, Jun Liu, Liang Li, Victor J Hassid, Donald P Baumann, Charles E Butler, Patrick B Garvey
BACKGROUND: Although multiple acellular dermal matrix (ADM) sources exist, it is unclear how ADM processing impacts complication rates. We compared complications between two preparations of human cadaveric ADM (freeze dried [hADM-FD] and ready to use [hADM-RTU]) in immediate tissue expander (TE) breast reconstruction to analyze the effect of processing on complications. HADM-FD is aseptic while hADM-RTU is sterilized and wet-packaged. METHODS: We retrospectively reviewed all TE breast reconstructions with hADM-FD or hADM-RTU at a single center between 2006 and 2016...
January 20, 2018: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/29643729/resterilized-polypropylene-mesh-for-inguinal-hernia-repair
#5
Isaac Assam Udo, Ifeanyi A Onwuezobe, Kingsley U Umeh
Purpose: The use of prosthetic biomaterials for reconstructing and reinforcing the posterior wall of the inguinal canal reduces the incidence of hernia recurrence. Cost, availability of mesh, and perhaps reluctance to adopt a new technique are factors which prevent widespread practice of hernioplasty in low-resource settings. Use of resterilized mesh significantly reduces the cost of hernioplasty and is safe. Patients and Methods: Sheets of 30 cm × 30 cm polypropylene mesh were cut into 16 cm × 8 cm to produce mesh strips which were repackaged into SELFSEAL® (Medical Action Industries Inc...
January 2018: Nigerian Journal of Surgery: Official Publication of the Nigerian Surgical Research Society
https://www.readbyqxmd.com/read/29628695/medical-textiles-in-orthopedics-an-overview
#6
REVIEW
Raju Vaishya, Amit Kumar Agarwal, Manish Tiwari, Abhishek Vaish, Vipul Vijay, Yash Nigam
The use of textile in the medical field is not new; this has given rise to a new branch known as medical textiles. These are being used to repair or replace various other musculoskeletal tissues. The most common uses of biomaterials are to create aseptic conditions for protection, general health care, and hygiene including bedding and clothing, surgical gowns, face masks, head and shoe covers, sterilization wraps, suture anchors, fiber cast and braces/orthotics. These are also used as materials for preparation of wipes, swabs, wound dressings, bandages, gauzes, plasters, pressure garments, orthopedic belts and for new applications, such as heart valves, vascular grafts, artificial veins, artificial ligaments, artificial joints, artificial skin, and artificial cartilage...
March 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29607515/implementation-of-secondary-bacterial-culture-testing-of-platelets-to-mitigate-residual-risk-of-septic-transfusion-reactions
#7
Evan M Bloch, Christi E Marshall, Joan S Boyd, Lisa Shifflett, Aaron A R Tobian, Eric A Gehrie, Paul M Ness
BACKGROUND: Bacterial contamination of platelets remains a major transfusion-associated risk despite long-standing safety measures in the United States. We evaluated an approach using secondary bacterial culture (SBC) to contend with residual risk of bacterial contamination. STUDY DESIGN AND METHODS: Phased implementation of SBC was initiated in October 2016 for platelets (all apheresis collected) received at our institution from the blood donor center (Day 3 post collection)...
April 1, 2018: Transfusion
https://www.readbyqxmd.com/read/29545321/vapor-phase-hydrogen-peroxide-sanitization-of-an-isolator-for-aseptic-filling-of-monoclonal-antibody-drug-product-hydrogen-peroxide-uptake-and-impact-on-protein-quality
#8
Aaron Hubbard, Thomas Reodl, Ada Hui, Stephanie Knueppel, Kirk Eppler, Siegfried Lehnert, Yuh-Fun Maa
A monoclonal antibody drug product (DP) manufacturing process was transferred to a different production site, where aseptic filling took place within an isolator that was sanitized using vapor phase hydrogen peroxide (VPHP). A quality-by-design approach was applied for study design to understand the impact of VPHP uptake in the isolator on DP quality. A combination of small-scale and manufacturing-scale studies was performed to evaluate the sensitivity of the monoclonal antibody to hydrogen peroxide (H2O2) as well as VPHP uptake mechanisms during the filling process...
March 15, 2018: PDA Journal of Pharmaceutical Science and Technology
https://www.readbyqxmd.com/read/29512359/nondestructive-assessment-of-collagen-hydrogel-cross-linking-using-time-resolved-autofluorescence-imaging
#9
Benjamin E Sherlock, Jenna N Harvestine, Debika Mitra, Anne Haudenschild, Jerry Hu, Kyriacos A Athanasiou, J Kent Leach, Laura Marcu
We investigate the use of a fiber-based, multispectral fluorescence lifetime imaging (FLIm) system to nondestructively monitor changes in mechanical properties of collagen hydrogels caused by controlled application of widely used cross-linking agents, glutaraldehyde (GTA) and ribose. Postcross-linking, fluorescence lifetime images are acquired prior to the hydrogels being processed by rheological or tensile testing to directly probe gel mechanical properties. To preserve the sterility of the ribose-treated gels, FLIm is performed inside a biosafety cabinet (BSC)...
March 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29436708/nursing-wound-care-practices-in-haiti-facilitators-and-barriers-to-quality-care
#10
B A Timmins, C Thomas Riché, M W Saint-Jean, J Tuck, L Merry
AIM: To describe the facilitators and barriers for nurses to perform quality wound care in three surgical wards of a hospital in Port-au-Prince, Haiti. BACKGROUND: Up to a quarter of patients in low- and middle-income countries may acquire at least one infection while hospitalized. There is a paucity of research investigating nursing wound care practices in low- and middle-income countries regarding the prevention of hospital-acquired infections. METHODS: The design was qualitative descriptive...
February 13, 2018: International Nursing Review
https://www.readbyqxmd.com/read/29406793/development-and-evaluation-of-a-novel-microemulsion-of-dexamethasone-and-tobramycin-for-topical-ocular-administration
#11
Rinda Devi Bachu, Marina Stepanski, Rami M Alzhrani, Rose Jung, Sai H S Boddu
PURPOSE: The purpose of this study was to develop and evaluate a novel dexamethasone- and tobramycin-loaded microemulsion for its potential for treating anterior segment eye infections. METHODS: The microemulsion was evaluated for pH, particle size, zeta potential, light transmittance, morphology, and in vitro drug release. Sterility of the microemulsion was evaluated by direct as well as plate inoculation methods. Anti-inflammatory activity of dexamethasone, bactericidal activity of tobramycin, and cytotoxicity of the microemulsion were assessed and compared to that of the marketed eye drop suspension (Tobradex® )...
February 6, 2018: Journal of Ocular Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29386784/evaluation-of-new-technique-of-sterilization-using-biological-indicator
#12
Nomal Chintan Sheth, Yogesh V Rathod, Pratima R Shenoi, Deepa D Shori, Rajiv T Khode, Amruta P Khadse
Background: A novel technique of sterilization of endodontic files is introduced in this article. Aims: Newly introduced sterilization unit, named "SteriFast" is compared with autoclave and glass bead sterilizer using biological indicator. Materials and Methods: Spore strips of Bacillus pumilus were cultured in nutrient broth. This cultured media was used to contaminate the experimental samples of endodontic files. These contaminated files were sterilized using three different techniques...
September 2017: Journal of Conservative Dentistry: JCD
https://www.readbyqxmd.com/read/29382603/sonication-of-orthopaedic-implants-a-valuable-technique-for-diagnosis-of-prosthetic-joint-infections
#13
Sujeesh Sebastian, Rajesh Malhotra, Vishnubhatla Sreenivas, Arti Kapil, Rama Chaudhry, Benu Dhawan
INTRODUCTION: Accurate and prompt microbiological diagnosis of prosthetic joint infection (PJI) is crucial for successful antimicrobial treatment. Studies have shown the diagnostic utility of sonication of explanted implants in total joint arthroplasty but all did not use consensus statements for defining PJI. We evaluated the diagnostic utility of culture of samples obtained by sonication of explanted implants compared with periprosthetic tissue cultures (PTC) for the diagnosis of PJI using Musculoskeletal Infection Society (MSIS) consensus criteria...
March 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29361108/the-effect-of-refined-functional-carbohydrates-from-enzymatically-hydrolyzed-yeast-on-the-transmission-of-environmental-salmonella-senftenberg-among-broilers-and-proliferation-in-broiler-housing
#14
G K Walker, S Jalukar, J Brake
Hatching eggs collected from resident broiler breeders at 48 wk of age were used to produce male and female chicks that were assigned sex separately to 96 new litter pens and fed either a 0 or 50 g/MT RFC (refined functional carbohydrate feed additive derived from yeast) diet. There were 24 replicate pens of 12 broilers each per diet per sex. Feed intake and BW were determined at 14, 28, and 42 d of age. Litter was sampled by pen using sterile socks at 35 d and tested for Salmonella spp. using an enzyme linked fluorescence assay method...
April 1, 2018: Poultry Science
https://www.readbyqxmd.com/read/29311196/non-touch-aseptic-technique-maintains-sterility-of-antibiotic-admixed-peritoneal-dialysis-fluid
#15
Louis L Huang, Ellen Ramas, Priti Prasad, Jenny Catania, Pauline Meade, Eamonn Butler, Lawrence P McMahon
There is a paucity of data on the sterility of peritoneal dialysis fluid (PDF) after drug admixture. International Society for Peritoneal Dialysis (ISPD) guidelines suggest using sterile technique when admixing antibiotics; however, the degree of sterility remains unclear. This issue is most pertinent when preparing take-home PDF for outpatient treatment of peritonitis. This study compares the sterility of PDF admixed with antibiotics using a non-touch aseptic technique (NTAT) versus sterile technique.Groups of 8 PDF mixtures (1...
January 2018: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
https://www.readbyqxmd.com/read/29295779/a-survey-of-international-antisepsis-procedures-for-neuraxial-catheterisation-in-labour
#16
K Fayman, A Allan, C Hudson, M Logarta
BACKGROUND: Neuraxial analgesia during labour is a mainstay of anaesthetic practice globally. Despite the potential for significant neurological and infectious complications, international antisepsis practices for neuraxial anaesthesia vary widely. AIMS: The primary aim of this study was to clarify international antisepsis practices prior to neuraxial analgesia in labour. The secondary aim was to determine an approximate international incidence of neuraxial infections and neurological complications secondary to neuraxial analgesia techniques in labour...
February 2018: International Journal of Obstetric Anesthesia
https://www.readbyqxmd.com/read/29284355/stability-of-sodium-bicarbonate-injection-8-4-in-syringes-over-a-six-week-period-in-refrigerated-temperature
#17
Jack T Seki, Tian Q Wang, Paul M Yip, Tony Mazzulli, Mark D Minden
Background Dysfunctional central venous catheter prohibits the administration of potential life-saving chemotherapy and the delivery of essential supportive care needs to patients. Sodium bicarbonate injection has been shown to impede against fibrin clot formation and prolong prothrombin time and thrombin clotting time. Sodium bicarbonate injection has been tried as a second-line agent with good results in a small number of patients (internal data not published) when alteplase failed. We assessed whether the pre-filled sodium bicarbonate injection in 5 mL syringes would not only preserve sterility and retain its pH and concentration but also amount to the potential cost savings for future use when stored in a refrigerated environment...
April 2018: Journal of Oncology Pharmacy Practice
https://www.readbyqxmd.com/read/29276291/extended-stability-of-epinephrine-hydrochloride-injection-in-polyvinyl-chloride-bags-stored-in-amber-ultraviolet-light-blocking-bags
#18
Edward T Van Matre, Kang C Ho, Clark Lyda, Beth A Fullmer, Alan R Oldland, Tyree H Kiser
Objective: The objective of this study was to evaluate the stability of epinephrine hydrochloride in 0.9% sodium chloride in polyvinyl chloride bags for up to 60 days. Methods: Dilutions of epinephrine hydrochloride to concentrations of 16 and 64 µg/mL were performed under aseptic conditions. The bags were then placed into ultraviolet light-blocking bags and stored at room temperature (23°C-25°C) or under refrigeration (3°C-5°C). Three samples of each preparation and storage environment were analyzed on days 0, 30, 45, and 60...
September 2017: Hospital Pharmacy
https://www.readbyqxmd.com/read/29219196/evaluation-of-efficacy-of-repeated-decontamination-and-sterilization-of-single-incision-laparoscopic-surgery-ports-intended-for-1-time-use
#19
Brian Petrovsky, Eric Monnet
OBJECTIVE: To determine the efficacy of repeated decontamination and sterilization of a disposable port intended for 1-time use during single-incision laparoscopy. STUDY DESIGN: Experimental; prospective, controlled design. METHODS: Six single-access ports used 4 times and 6 single-access ports used 8 times to perform various clean, minimally invasive surgeries were evaluated. Ports were decontaminated in an enzymatic cleaner (dilution, 3:100) and cleaned with a scrub brush for 5 minutes...
December 8, 2017: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/29212102/-conservative-treatment-of-an-aseptic-abscess-syndrome-with-splenic-abscesses-in-crohn-s-disease
#20
Thomas Göbel, Jutta Rauen-Vossloh, Hubert Georg Hotz, Andree Boldt, Andreas Erhardt
A 24-year old woman with a history of Crohn's disease developed bloody diarrhea and multiple abdominal abscesses, daily fever, leukocytosis, and elevated CRP several months after her immunosuppressive therapy with azathioprine was stopped. Recurrent abscess punctures did not detect any pathogenic germs and neither clinical nor serological response was achieved by administration of different antimicrobial therapies. Additionally, new splenic abscesses arose despite ongoing therapy. Under the suspicion of the rare aseptic abscess syndrome, representing an auto-inflammatory, extra-intestinal manifestation of Crohn's disease, the antimicrobial therapy was stopped and an intravenous therapy with prednisolone was initiated...
December 2017: Zeitschrift Für Gastroenterologie
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