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https://www.readbyqxmd.com/read/29928444/expression-signature-of-ten-genes-predicts-the-survival-of-patients-with-estrogen-receptor-positive-breast-cancer-that-were-treated-with-tamoxifen
#1
He Huang, Qiyu Chen, Weijian Sun, Mingdong Lu, Yaojun Yu, Zhiqiang Zheng, Pihong Li
Although tamoxifen is the most frequently used drug for the treatment of estrogen receptor positive (ER+ )-breast cancer (BRCA), its efficacy varies between patients. In the present study, Cox multivariate regression of the relative mRNA expression levels in two microarray-based datasets (GSE17005 and GSE26971) was employed to develop a risk score model to evaluate the outcome of patients with BRCA in the GSE17005 dataset. A total of ten genes were used to develop the prediction model for the survival of tamoxifen-treated patients with breast cancer...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928384/-tp53-mutations-and-snps-as-prognostic-and-predictive-factors-in-patients-with-breast-cancer
#2
REVIEW
Joanna Huszno, Ewa Grzybowska
Tumor protein 53 ( TP53 ) is a tumor suppressor gene that encodes tumor protein p53. Tumor protein p53 regulates the expression of target genes in response to cellular stress. Additionally, p53 participates in the regulation of cell cycle checkpoints, DNA repair and apoptosis. Mutations in the TP53 gene are associated with numerous types of human cancer, including breast cancer, sarcomas, brain tumors and adrenal cortical carcinomas. In breast cancer, TP53 mutations are a negative prognostic factor. Tumors with TP53 mutations are more likely to be aggressive (triple-negative or human epidermal growth factor receptor 2-positive breast cancer), and resistant to chemotherapy and radiotherapy...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29925345/induction-therapy-with-paclitaxel-and-bevacizumab-followed-by-switch-maintenance-therapy-with-eribulin-in-japanese-patients-with-her2-negative-metastatic-breast-cancer-a-multicenter-collaborative-open-label-phase-ii-clinical-study-for-the-sbccsg-35-investigators
#3
Kenichi Inoue, Jun Ninomiya, Tsuyoshi Saito, Kei Kimizuka, Masafumi Kurosumi
BACKGROUND: To examine the efficacy and safety of induction therapy with paclitaxel and bevacizumab followed by switch maintenance therapy with eribulin (ISMT) in Japanese patients with HER2-negative metastatic breast cancer (MBC). METHODS: Patients, who had previously undergone a maximum of 2 regimens of chemotherapy, received 3 cycles of induction therapy with paclitaxel (90 mg/m2 intravenously on days 1, 8, and 15 followed by 1-week drug holiday) and bevacizumab (10 mg/kg intravenously after the completion of paclitaxel administration on days 1 and 15)...
June 20, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29924666/selection-of-optimal-adjuvant-chemotherapy-and-targeted-therapy-for-early-breast-cancer-asco-clinical-practice-guideline-focused-update-summary
#4
Neelima Denduluri, Mark R Somerfield, Sharon H Giordano
No abstract text is available yet for this article.
June 20, 2018: Journal of Oncology Practice
https://www.readbyqxmd.com/read/29924336/effects-of-cryotherapy-on-objective-and-subjective-symptoms-of-paclitaxel-induced-neuropathy-prospective-self-controlled-trial
#5
Akiko Hanai, Hiroshi Ishiguro, Takashi Sozu, Moe Tsuda, Ikuko Yano, Takayuki Nakagawa, Satoshi Imai, Yoko Hamabe, Masakazu Toi, Hidenori Arai, Tadao Tsuboyama
Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a dose-limiting and disabling side effect of taxane anticancer agents. We prospectively evaluated the efficacy of cryotherapy for CIPN prevention. Methods: Breast cancer patients treated weekly with paclitaxel (80 mg/m2 for one hour) wore frozen gloves and socks on the dominant side for 90 minutes, including the entire duration of drug infusion. Symptoms on the treated sides were compared with those on the untreated (nondominant) sides...
February 1, 2018: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/29924229/prevalence-of-dermatological-complaints-in-patients-undergoing-treatment-for-breast-cancer
#6
Tamara Hoffmann, Mariane Corrêa-Fissmer, Camila Soares Duarte, Rayane Felippe Nazário, Ana Beatriz Sanches Barranco, Karen Waleska Knipoff de Oliveira
BACKGROUND: Internal malignancies such as breast cancer, as well as their treatment can often result in skin changes. OBJECTIVE: To assess the prevalence of dermatological complaints in patients who are undergoing oncological treatment for breast cancer in a hospital in Tubarão, Santa Catarina, Brazil. METHODS: Observational, cross-sectional study, from October 2015 to February 2016 in which 152 patients with the diagnosis of breast cancer, undergoing treatment with chemotherapy, radiotherapy, hormone therapy and/or surgery, were interviewed and completed a research protocol developed by the author...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29924228/exuberant-case-of-cutaneous-metastasis-of-breast-cancer
#7
Vítor Angelo Ferreira, Karla Spelta, Lucia Martins Diniz, Elton Almeida Lucas
Cutaneous metastasis is the main cause of morbidity and mortality of cancer patients, denoting a guarded prognosis. The clinical spectrum of the disease is broad and can mimic benign conditions. The diagnosis depends on thorough clinical examination and complementary exams, with emphasis on the histopathological study and immunohistochemistry. Because it indicates a systemic relapse, it is necessary to intervene with intravenous chemotherapy, to which local therapies can be associated. We report the case of a 65-year-old woman with cutaneous metastasis from breast cancer treated 14 years back, manifested by extensive firm and infiltrated red-purple plaques on the sides of the trunk, with a course of six months...
June 2018: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29923726/cargo-free-nano-medicine-with-ph-sensitivity-for-co-delivery-of-dox-conjugated-prodrug-with-sn38-to-synergistically-eradicate-breast-cancer-stem-cells
#8
Na Sun, Chenyang Zhao, Rui Cheng, Zerong Liu, Xian Li, Axin Lu, Zhongmin Tian, Zhe Yang
Due to their abilities of transforming into bulk cancer cells and resistance to radiotherapy and chemotherapy, cancer stem cells (CSCs) are currently considered as a major obstacle for cancer treatment. Application of multiple drugs using nano-carriers is a promising approach to simultaneously eliminate non-cancer stem cells (non-CSCs) and CSCs. Herein, to employ the advantages of nano-medicine while avoiding new excipients, pH-responsive pro-drug (PEG-CH=N-DOX) was employed as the surfactant to fabricate cargo-free nano-medicine for co-delivery of DOX conjugated prodrug with SN38 to synergistically eradicate breast cancer stem cells (bCSCs) and non-bCSCs...
June 20, 2018: Molecular Pharmaceutics
https://www.readbyqxmd.com/read/29923182/profiles-of-brain-metastases-prioritization-of-therapeutic-targets
#9
Sherise D Ferguson, Siyuan Zheng, Joanne Xiu, Shouhao Zhou, Mustafa Khasraw, Priscilla K Brastianos, Santosh Kesari, Jethro Hu, Jeremy Rudnick, Michael E Salacz, David Piccioni, Suyun Huang, Michael A Davies, Isabella C Glitza, John V Heymach, Jianjun Zhang, Nuhad K Ibrahim, John F DeGroot, Joseph McCarty, Barbara J O'Brien, Raymond Sawaya, Roeland G W Verhaak, Sandeep K Reddy, Waldemar Priebe, Zoran Gatalica, David Spetzler, Amy B Heimberger
We sought to compare the tumor profiles of brain metastases from common cancers with those of primary tumors and extracranial metastases in order to identify potential targets and prioritize rational treatment strategies. Tumor samples were collected from both the primary and metastatic sites of non-small cell lung cancer, breast cancer, and melanoma from patients in locations worldwide, and these were submitted to Caris Life Sciences for tumor multiplatform analysis, including gene sequencing (Sanger and next-generation sequencing with a targeted 47-gene panel), protein expression (assayed by immunohistochemistry), and gene amplification (assayed by in situ hybridization)...
June 19, 2018: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/29923063/persistent-major-alopecia-following-adjuvant-docetaxel-for-breast-cancer-incidence-characteristics-and-prevention-with-scalp-cooling
#10
M Martín, J C de la Torre-Montero, S López-Tarruella, K Pinilla, A Casado, S Fernandez, Y Jerez, J Puente, I Palomero, R González Del Val, M Del Monte-Millan, T Massarrah, C Vila, B García-Paredes, J A García-Sáenz, A Lluch
BACKGROUND: Persistent alopecia (PA) after docetaxel has been recently described. The aim of our study is to establish the incidence and characteristics of PA following adjuvant docetaxel for breast cancer (BC) and to test the ability of scalp cooling in prevention. PATIENTS AND METHODS: BC patients receiving adjuvant chemotherapy followed or not by endocrine therapy (and a control group receiving only endocrine therapy) were interviewed in a single institution at 1...
June 19, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29923058/evaluation-breast-cancer-information-on-the-internet-in-arabic
#11
Lamya Alnaim
Nowadays, medical information regarding various diseases and disorders is available online. The Internet has become the first choice for the patient when it comes to gathering detailed information about a disease or problem. Therefore, in view of this frequent occurrence, the information that is provided online needs to be accurate; providing comprehensive facts, transparency, and quality. A study was carried out to determine the accuracy of information related to breast cancer on various websites. Websites which share information online about breast cancer, in the Arabic language, were selected...
June 20, 2018: Journal of Cancer Education: the Official Journal of the American Association for Cancer Education
https://www.readbyqxmd.com/read/29922710/aspirin-use-correlates-with-survival-in-women-with-clear-cell-ovarian-cancer
#12
Alyssa M Wield, Christine S Walsh, B J Rimel, Ilana Cass, Beth Y Karlan, Andrew J Li
Data from colon, breast and prostate cancers suggest that aspirin users have reduced mortality. While the direct mechanism remains uncertain, aspirin can suppress the COX-dependent and independent pathways involved in tumor progression. We hypothesized that aspirin users with clear cell ovarian cancer would have improved survival outcomes. We performed a retrospective review of patients with clear cell ovarian cancer diagnosed between 1995 and 2010, and followed outcomes through 2016. Patients underwent primary cytoreductive surgery followed by platinum-based chemotherapy...
August 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29922098/exploring-the-effectiveness-of-crisis-counseling-and-psychoeducation-in-relation-to-improving-mental-well-being-quality-of-life-and-treatment-compliance-of-breast-cancer-patients-in-qatar
#13
Reem Jawad Al-Sulaiman, Abdulbari Bener, Lisa Doodson, Salha Bujassoum Al Bader, Suhaila Ghuloum, Alain Lemaux, Hekmat Bugrein, Reena Alassam, Aisha Karim
Background: An insufficient number of studies have been carried out in the Middle East to evaluate the role of structured psychotherapeutic interventions in enhancing breast cancer patients' psychological well-being, quality of life and treatment compliance. This study has been designed to address this limitation by exploring the benefit of two structured psychotherapeutic interventions, crisis counseling and psychoeducation, in enhancing breast cancer patients' psychological well-being, quality of life and treatment compliance in Qatar...
2018: International Journal of Women's Health
https://www.readbyqxmd.com/read/29921732/chemotherapy-sensitizes-therapy-resistant-cells-to-mild-hyperthermia-by-suppressing-heat-shock-protein-27-expression-in-triple-negative-breast-cancer
#14
Haifa Shen, Chaofeng Mu, Xiaoyan Wu, Xinyu Zhou, Joy Wolfram, Jianliang Shen, Dechen Zhang, Junhua Mai, Xiaojun Xia, Ashley M Holder, Mauro Ferrari, Xuewu Liu
PURPOSE: Triple-negative breast cancer (TNBC) is a clinically aggressive disease with poor prognosis. Conventional chemotherapeutics are generally able to shrink the tumor mass, but often fail to completely eradicate cancer stem-like cells (CSCs) that are responsible for high risk of relapse and frequent metastases. In this study, we examined thermal sensibility of CSCs, developed an approach that enabled concurrent elimination of both the bulk of cancer cells and CSCs, and investigated the underlying mechanism...
June 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29921729/integrating-radiosensitivity-and-immune-gene-signatures-for-predicting-benefit-of-radiotherapy-in-breast-cancer
#15
Yi Cui, Bailiang Li, Erqi Liu Pollom, Kathleen Horst, Ruijiang Li
PURPOSE: Breast cancer is a heterogeneous disease and not all patients respond equally to adjuvant radiotherapy. Predictive biomarkers are needed to select patients who will benefit from the treatment and spare others the toxicity and burden of radiation. EXPERIMENTAL DESIGN: We first trained and tested an intrinsic radiosensitivity gene signature to predict local recurrence after radiotherapy in three cohorts of 948 patients. Next, we developed an antigen processing and presentation-based immune signature by maximizing the treatment interaction effect in 129 patients...
June 19, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29920746/pathologist-s-health-care-value-in-the-triage-of-oncotype-dx-%C3%A2-testing-a-value-based-pathology-study-of-tumor-biology-with-outcomes
#16
David J Dabbs, Beth Z Clark, Kate Serdy, Agnieszka Onisko, Adam Brufsky, Sherie Smalley, Stephen Perkins, Rohit Bhargava
BACKGROUND: Pathologists provide expert tissue assessment of breast cancer, yet their value to guide the appropriate use of breast cancer gene expression profile (GEP) tests is underutilized. The specific aims of this study are to report morpho-immunohistologic characteristics of breast tumors with Oncotype DX® (ODx) Recurrence Scores (RS) of 10 or less (ultra-low risk) and 25 or less (low risk) in order to determine if pathologists can prospectively identify patient tumors that do not require ODx testing...
June 19, 2018: Histopathology
https://www.readbyqxmd.com/read/29917035/how-can-nanotechnology-help-the-fight-against-breast-cancer
#17
REVIEW
Elisabetta Avitabile, Davide Bedognetti, Gianni Ciofani, Alberto Bianco, Lucia Gemma Delogu
In this review we provide a broad overview on the use of nanotechnology for the fight against breast cancer (BC). Nowadays, detection, diagnosis, treatment, and prevention may be possible thanks to the application of nanotechnology to clinical practice. Taking into consideration the different forms of BC and the disease status, nanomaterials can be designed to meet the most forefront objectives of modern therapy and diagnosis. We have analyzed in detail three main groups of nanomaterial applications for BC treatment and diagnosis...
June 19, 2018: Nanoscale
https://www.readbyqxmd.com/read/29915994/the-impact-of-an-expressive-writing-intervention-on-quality-of-life-among-chinese-breast-cancer-patients-undergoing-chemotherapy
#18
Qian Lu, Lu Dong, Ivan H C Wu, Jin You, Jialing Huang, Yan Hu
BACKGROUND: Expressive writing interventions are shown to confer physical and psychological benefits for Caucasian cancer survivors. This study evaluated the health benefits of an expressive writing intervention among breast cancer patients in mainland China. METHODS: Stage I-III Chinese breast cancer survivors undergoing chemotherapy were recruited in Shanghai, China. They (n = 90) were randomly assigned to one of three conditions: a positive thinking group (PTC) to write about the positive aspects of their cancer experience; a self-regulation condition (SRC) to write about their stress and coping efforts, deepest feelings, and positive aspects of their cancer experience; or a cancer-fact group (CFC) to write about facts relevant to their cancer experience...
June 18, 2018: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/29915948/thyroid-hormone-receptor-beta-1-expression-in-early-breast-cancer-a-validation-study
#19
K J Jerzak, J G Cockburn, S K Dhesy-Thind, G R Pond, K I Pritchard, S Nofech-Mozes, P Sun, S A Narod, A Bane
PURPOSE: Preliminary data suggest that high expression of the TRβ1 tumor suppressor is associated with longer survival among women with early breast cancer. We undertook this study to validate these findings. METHODS: In this prospective cohort study, we analyzed the prognostic significance of TRβ1 protein expression in the breast tumors of 796 women who had undergone breast surgery in the Henrietta Banting Breast Cancer database. All women were recruited after undergoing primary surgical therapy at Women's College Hospital (Toronto, ON, Canada) between January 1987 and December 2000...
June 18, 2018: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/29915946/impact-of-change-in-body-mass-index-during-neoadjuvant-chemotherapy-and-survival-among-breast-cancer-subtypes
#20
Takahiro Kogawa, Takeo Fujii, Tamer M Fouad, Diane D Liu, Kenichi Harano, Hiroko Masuda, Toshiaki Iwase, Chad Barnett, Young Sam Park, Bora Lim, Debu Tripathy, Jennifer K Litton, Naoto T Ueno
PURPOSE: We hypothesized that an increase in BMI category during neoadjuvant chemotherapy (NAC) would be associated with pathological complete response (pCR) rate and worse survival outcomes in primary breast cancer patients. METHODS: We reviewed the records of 4029 patients with stage I-III breast cancer who had undergone NAC and definitive surgery at our institution between May 1, 1990 and April 30, 2013. BMI values at baseline and after NAC were recorded, and the corresponding BMI category was assessed with the WHO classification...
June 18, 2018: Breast Cancer Research and Treatment
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