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https://www.readbyqxmd.com/read/28329376/comparison-of-the-prognostic-value-of-negative-non-invasive-cardiac-investigations-in-patients-with-suspected-or-known-coronary-artery-disease-a-meta-analysis
#1
Martijn W Smulders, Caroline Jaarsma, Patricia J Nelemans, Sebastiaan C A M Bekkers, Jan Bucerius, Tim Leiner, Harry J G M Crijns, Joachim E Wildberger, Simon Schalla
Aims: To compare the prognostic value of negative non-invasive cardiac investigations (coronary computed tomographic angiography [CCTA], cardiovascular magnetic resonance [CMR], exercise electrocardiographic testing [EET], positron emission tomography [PET], stress-echocardiography [SE], and single-photon emission tomography [SPECT]) in patients with suspected or known coronary artery disease (CAD) and to explore the effect of adjustment for population event risk and presence of CAD. Methods and results: MEDLINE/PubMed database, EMBASE and Cochrane Library were searched from January-1990 to April-2015 for studies reporting annual event rates (AER) of myocardial infarction (MI) and cardiac death...
February 27, 2017: European Heart Journal Cardiovascular Imaging
https://www.readbyqxmd.com/read/28326754/supporting-imaging-modalities-for-improving-diagnosis-of-prosthesis-endocarditis-preliminary-results-of-a-single-center-experience-with-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography
#2
Anna Kokalova, Angelo M Dell'AQUILA, Nemanja Avramovic, Sven Martens, Christian Wenning, Jürgen R Sindermann
AIM: The aim of current study was to evaluate the role of PET-CT in the diagnosis of prosthetic valve endocarditis (PVE). METHODS: This is a single-center study including 13 PET/CT examinations performed between February 2009 and March 2016 in 13 patients (76.9% men, mean age 68.1 years, IQR 11.1) because of suspect of PVE. Median interval time between first operation and PET/CT examination was 19.02 months (lQR 85.5). Final diagnosis was made according to pathological criteria (histological and microbiological) of the Duke classification...
March 21, 2017: Minerva Medica
https://www.readbyqxmd.com/read/28326465/pet-ct-evaluation-of-amyloid-systemic-involvement-with-18-f-florbetaben-in-patient-with-proved-cardiac-amyloidosis-a-case-report
#3
Dario Genovesi, Giuseppe Vergaro, Michele Emdin, Assuero Giorgetti, Paolo Marzullo
BACKGROUND: One of the most frequent disorders which lead to cardiac amyloidosis is transthyretin-related amyloidosis (ATTR). Some PET radio-pharmaceuticals for the detection of beta-amyloid deposits within the brain have shown to be able to detect also cardiac amyloid deposits. We present a case of a man with ATTR studied with [(18)F]-florbetaben PET-CT. RESULTS: Total-body scan showed a moderate uptake in the bone marrow, especially in correspondence of the vertebral column, while no significant myocardial uptake was present...
March 21, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28322043/-sup-18-sup-f-fluoro-hydroxyphenethylguanidines-efficient-synthesis-and-comparison-of-two-structural-isomers-as-radiotracers-of-cardiac-sympathetic-innervation
#4
Yong-Woon Jung, Keun Sam Jang, Guie Gu, Robert A Koeppe, Phillip S Sherman, Carole A Quesada, David M Raffel
Fluorine-18 labeled phenethylguanidines are currently under development in our laboratory as radiotracers for quantifying regional cardiac sympathetic nerve density using PET imaging techniques. In this study, we report an efficient synthesis of <sup>18</sup>F-hydroxyphenethylguanidines consisting of nucleophilic aromatic [<sup>18</sup>F]fluorination of a protected diaryliodonium salt precursor followed by a single deprotection step to afford the desired radiolabeled compound. This approach has been shown to reliably produce 4-[<sup>18</sup>F]fluoro-<i>m</I>-hydroxyphenethylguanidine ([<sup>18</sup>F]4F-MHPG, [<sup>18</sup>F]<b>1</b>) and its structural isomer 3-[<sup>18</sup>F]fluoro-<i>p</i>-hydroxyphenethylguanidine ([<sup>18</sup>F]3F-PHPG, [<sup>18</sup>F]<b>2</b>) with good radiochemical yields...
March 21, 2017: ACS Chemical Neuroscience
https://www.readbyqxmd.com/read/28321682/recent-advances-and-clinical-applications-of-pet-cardiac-autonomic-nervous-system-imaging
#5
REVIEW
Nabil E Boutagy, Albert J Sinusas
PURPOSE OF REVIEW: The purpose of this review was to summarize current advances in positron emission tomography (PET) cardiac autonomic nervous system (ANS) imaging, with a specific focus on clinical applications of novel and established tracers. RECENT FINDINGS: [(11)C]-Meta-hydroxyephedrine (HED) has provided useful information in evaluation of normal and pathological cardiovascular function. Recently, [(11)C]-HED PET imaging was able to predict lethal arrhythmias, sudden cardiac death (SCD), and all-cause mortality in heart failure patients with reduced ejection fraction (HFrEF)...
April 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28318664/risk-assessment-of-patients-with-clinical-manifestations-of-cardiac-sarcoidosis-with-positron-emission-tomography-and-magnetic-resonance-imaging
#6
Paco E Bravo, Ganesh Raghu, David G Rosenthal, Shana Elman, Bradley J Petek, Laurie A Soine, Jeffrey H Maki, Kelley R Branch, Sofia C Masri, Kristen K Patton, James H Caldwell, Eric V Krieger
BACKGROUND: Prior studies have shown that late gadolinium enhancement (LGE) on cardiac magnetic resonance (CMR) and fluorodeoxyglucose (FDG) positron emission tomography (PET) confer incremental risk assessment in patients with cardiac sarcoidosis (CS). However, the incremental prognostic value of the combined use of LGE and FDG compared to either test alone has not been investigated, and this is the aim of the present study. METHODS: Retrospective observational study of 56 symptomatic patients with high clinical suspicion for CS who underwent LGE-CMR and FDG-PET and were followed for the occurrence of death and/or malignant ventricular arrhythmias (VA)...
March 10, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28317067/pet-cmr-in-heart-failure-synergistic-or-redundant-imaging
#7
REVIEW
Michael A Quail, Albert J Sinusas
Imaging in heart failure (HF) provides data for diagnosis, prognosis and disease monitoring. Both MRI and nuclear imaging techniques have been successfully used for this purpose in HF. Positron Emission Tomography-Cardiac Magnetic Resonance (PET-CMR) is an example of a new multimodality diagnostic imaging technique with potential applications in HF. The threshold for adopting a new diagnostic tool to clinical practice must necessarily be high, lest they exacerbate costs without improving care. New modalities must demonstrate clinical superiority, or at least equivalence, combined with another important advantage, such as lower cost or improved patient safety...
March 20, 2017: Heart Failure Reviews
https://www.readbyqxmd.com/read/28315124/multi-modality-imaging-assessment-of-pericardial-masses
#8
REVIEW
Wunan Zhou, Monvadi Barbara Srichai
PURPOSE OF REVIEW: This review will discuss the application of various imaging modalities including their advantages and disadvantages in the evaluation of the most common pericardial masses with a focus on pericardial cysts, tumors, and hematomas. RECENT FINDINGS: Accurate identification of pericardial masses and assessment of potential hemodynamic compromise is imperative for management. Cardiac imaging plays a central role in tissue characterization as well as evaluation of extension into neighboring structures...
April 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28306671/noninvasive-monitoring-of-acute-and-chronic-rejection-in-heart-transplantation
#9
Maria G Crespo-Leiro, Gonzalo Barge-Caballero, David Couto-Mallon
PURPOSE OF REVIEW: Recent years have seen advances in the early detection of cardiac graft rejection. RECENT FINDINGS: We review the possibilities offered by tissue Doppler imaging and speckle tracking echocardiography, cardiac magnetic resonance, cardiac computed tomography, single positron emission tomography, gene expression profiling, and quantitation of donor-derived cell-free DNA, and microRNAs. SUMMARY: Noninvasive monitoring of acute and chronic rejection after cardiac transplantation is an unmet need and remains a challenge...
March 16, 2017: Current Opinion in Cardiology
https://www.readbyqxmd.com/read/28306335/prognostic-value-of-normal-positron-emission-tomography-myocardial-perfusion-imaging-in-patients-with-known-or-suspected-coronary-artery-disease-a-meta-analysis
#10
A'Di Chen, HaoSen Wang, Bing Fan, YaWei Xu, Wei Chen, Neng Dai
OBJECTIVE: Several studies have confirmed high diagnostic performance of positron emission tomography (PET) myocardial perfusion imaging (MPI) in patients with known or suspected coronary artery disease (CAD). However, whether the superior diagnostic accuracy could translate into improved mortality outcomes remains unknown. The aim of this study was to define the prognostic value of normal PET MPI. METHODS: PubMed and EMBASE were searched to identify related studies up to June 2016...
March 17, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/28302764/-18-f-gp1-a-novel-fluorine-18-labeled-tracer-designed-for-pet-imaging-of-thrombi-with-high-detection-sensitivity-and-low-background
#11
Jessica Lohrke, Holger Siebeneicher, Markus Berger, Michael Reinhardt, Mathias Berndt, Andre Mueller, Marion Zerna, Norman Koglin, Felix Oden, Marcus Bauser, Matthias Friebe, Ludger M Dinkelborg, Joachim Huetter, Andrew W Stephens
Thromboembolic diseases such as myocardial infarction, stroke, transient ischemic attacks and pulmonary embolism are major causes of morbidity and mortality worldwide. GPIIb/IIIa is the key receptor involved in platelet aggregation and is a validated target for therapeutic approaches and diagnostic imaging. The aim of this study was to develop and characterize a specific small molecule tracer for positron emission tomography (PET) imaging that binds with high affinity to GPIIb/IIIa receptors and has suitable pharmacokinetic properties to overcome limitations of previous approaches...
March 16, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28288654/non-invasive-in-vivo-imaging-of-cardiac-stem-progenitor-cell-biodistribution-and-retention-after-intracoronary-and-intramyocardial-delivery-in-a-swine-model-of-chronic-ischemia-reperfusion-injury
#12
María Collantes, Beatriz Pelacho, María José García-Velloso, Juán José Gavira, Gloria Abizanda, Itziar Palacios, Luis Rodriguez-Borlado, Virginia Álvarez, Elena Prieto, Margarita Ecay, Eduardo Larequi, Iván Peñuelas, Felipe Prósper
BACKGROUND: The safety and efficacy of cardiac stem/progenitor cells (CSC) have been demonstrated in previous preclinical and clinical assays for heart failure. However, their optimal delivery route to the ischemic heart has not yet been assessed. This study was designed to determine by a non-invasive imaging technique (PET/CT) the biodistribution and acute retention of allogeneic pig CSC implanted by two different delivery routes, intracoronary (IC) and intramyocardial (IM), in a swine preclinical model of chronic ischemia-reperfusion...
March 13, 2017: Journal of Translational Medicine
https://www.readbyqxmd.com/read/28288049/catecholamine-induced-chest-pain-mimicking-infarction-due-to-an-mibg-negative-and-dopa-positive-succinate-dehydrogenase-syndrome-subunit-b-related-pheochromocytoma
#13
Alberto Mazza, Alice Ferretti, Antonella Paola Sacco, Domenico Rubello, Patrick M Colletti
This 16-year-old boy presented with acute retrosternal pain possibly representing acute myocardial infarction. Cardiac enzymes were within reference ranges. There were marked increases in metanephrine to 3299 μg/24 h (reference, <400 μg/24 h), normetanephrine to 1309 μg/24 h (reference, 0-390 μg/24 h), and chromogranin A to 1605 ng/mL (reference, 0-150 μg/24 h). An incidental left adrenal mass was found during CTPA performed to exclude pulmonary embolism. I-MIBG scintigraphy was negative, and genetic screening detected SDHB (succinate dehydrogenase syndrome subunit B) gene mutation...
March 10, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28283317/pilot-study-to-determine-the-feasibility-of-radiation-therapy-for-dogs-with-right-atrial-masses-and-hemorrhagic-pericardial-effusion
#14
M W Nolan, M M Arkans, D LaVine, T DeFrancesco, J A Myers, E H Griffith, L P Posner, B W Keene, S P Tou, T L Gieger
OBJECTIVES: To determine the short-term safety and biologic activity of radiation therapy (RT) for presumptive cardiac hemangiosarcoma in pet dogs. ANIMALS: Six dogs with echocardiographic evidence of a right atrial/auricular mass, and hemorrhagic pericardial effusion, were enrolled in a prospective, single-arm clinical trial. METHODS: A single fraction of 12 Gy was delivered using conformal external beam irradiation. Serum cardiac troponin I and plasma concentrations of vascular endothelial growth factor were quantified before, 4 and 24 h after RT...
March 7, 2017: Journal of Veterinary Cardiology: the Official Journal of the European Society of Veterinary Cardiology
https://www.readbyqxmd.com/read/28265641/-nuclear-medicine-in-germany-updated-key-data-and-trends-from-official-statistics
#15
Dirk Hellwig, Jörg Marienhagen, Karin Menhart, Jirka Grosse
AIM: Updated presentation of the spectrum of nuclear medicine in-vivo examinations and therapies from officially available statistics on out-patient and in-patient care as well as trends of structural data on nuclear medicine in Germany. METHODS: Data from the German Federal Health Monitoring, from the frequency statistics of the statutory health insurance for out-patients and from the German Medical Association were used and supplemented by data from selective literature searches...
March 7, 2017: Nuklearmedizin. Nuclear Medicine
https://www.readbyqxmd.com/read/28263213/abnormal-18-f-fdg-and-82-rb-pet-findings-in-chagas-heart-disease
#16
Medhi S Salimy, Purvi J Parwani, Kanae Mukai, Miguel Hernandez Pampaloni, Robert R Flavell
Uptake of the radiopharmaceutical F-FDG visualized by PET imaging can reflect abnormal myocardial inflammation. When utilized in conjunction with other imaging modalities, such as echocardiography, PET F-FDG imaging can help distinguish between active cardiac sarcoidosis and other etiologies of nonischemic cardiomyopathy. We present a case of a 46-year-old man with nonischemic cardiomyopathy and ventricular tachycardia who underwent an echocardiogram suggestive of cardiac Chagas disease. A subsequent F-FDG PET demonstrated abnormal hypermetabolism...
March 3, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28254873/inter-and-intra-observer-agreement-of-fdg-pet-ct-image-interpretation-in-patients-referred-for-assessment-of-cardiac-sarcoidosis
#17
Hiroshi Ohira, Brian Mc Ardle, Robert A deKemp, Pablo B Nery, Daniel Juneau, Jennifer M Renaud, Ran Klein, Owen Clarkin, Karen MacDonald, Eugene Leung, Girish Nair, Rob S B Beanlands, David Birnie
Recent studies have reported the usefulness of (18)F-fluoro-2-deoxyglucose positron emission tomography (FDG-PET) in aiding with the diagnosis and management of patients with cardiac sarcoidosis (CS). However, the image interpretation of FDG-PET for CS is sometimes challenging. We sought to investigate the inter- and intra-observer agreement and explore factors which lead to important discrepancies between readers. METHODS: We studied consecutive patients with no significant coronary artery disease who were referred for assessment of CS...
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28254864/arterial-co2-as-a-potent-coronary-vasodilator-a-preclinical-pet-mr-validation-study-with-implications-for-cardiac-stress-testing
#18
Hsin-Jung Yang, Damini Dey, Jane Sykes, Michael Klein, John Butler, Michael Kovacs, Olivia Sobczyk, Behzad Sharif, Xiaoming Bi, Avinash Kali, Ivan Cokic, Richard Tang, Roya Yumul, Antonio Conte, Sotirios Tsaftaris, Mourad Tighiouart, Debiao Li, Piotr J Slomka, Daniel Berman, Frank Prato, Joseph Fisher, Rohan Dharmakumar
Myocardial blood flow (MBF) is the critical determinant of cardiac function. However, its response to increases in partial pressure of arterial CO2 (PaCO2), particularly with respect to adenosine, is not well characterized due to challenges in blood gas control and limited availability of validated approaches to ascertain MBF in vivo. By prospectively and independently controlling PaCO2 and combining it with (13)N-ammonia Positron Emission Tomography (PET) measurements, we investigated whether a physiologically tolerable hypercapnic stimulus (~25-mmHg increase in PaCO2) can increase MBF to that observed with adenosine in three groups of canines: (i) without coronary stenosis; (ii) subjected to non-flow limiting coronary stenosis; and (iii) following pre-administration of caffeine...
March 2, 2017: Journal of Nuclear Medicine: Official Publication, Society of Nuclear Medicine
https://www.readbyqxmd.com/read/28252451/enhancing-ejection-fraction-measurement-through-4d-respiratory-motion-compensation-in-cardiac-pet-imaging
#19
Jing Tang, Xinhui Wang, Xiangzhen Gao, Paul Segars, Martin Lodge, Arman Rahmim
ECG gated cardiac PET imaging measures functional parameters such as left ventricle (LV) ejection fraction (EF), providing diagnostic and prognostic information for management of patients with coronary artery disease (CAD). Respiratory motion degrades spatial resolution and affects the accuracy in measuring the LV volumes for EF calculation. The goal of this study is to systematically investigate the effect of respiratory motion correction on the estimation of end-diastolic volume (EDV), end-systolic volume (ESV), and EF, especially on the separation of normal and abnormal EFs...
March 2, 2017: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/28250862/fdg-pet-identification-of-infected-pulmonary-artery-conduit-following-tetralogy-of-fallot-tof-repair
#20
Yuyang Zhang, Hadyn Williams, Darko Pucar
Tetralogy of Fallot (TOF) is one of the most common forms of cyanotic congenital heart disease usually managed by serial surgical repairs. The repaired prosthetic valve or conduit is susceptible to life-threatening infection. FDG-PET is an effective alternative to evaluate the source of infection when other examinations are inconclusive. We report an unusual case of an infected pulmonary artery conduit after TOF repair although the echocardiogram was negative for vegetation, which was later confirmed by surgery and pathology...
March 2017: Nuclear Medicine and Molecular Imaging
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