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https://www.readbyqxmd.com/read/28442712/cardioprotective-effects-of-cu-ii-atsm-in-human-vascular-smooth-muscle-cells-and-cardiomyocytes-mediated-by-nrf2-and-dj-1
#1
Salil Srivastava, Philip J Blower, Aisah A Aubdool, Robert C Hider, Giovanni E Mann, Richard C Siow
Cu((II))ATSM was developed as a hypoxia sensitive positron emission tomography agent. Recent reports have highlighted the neuroprotective properties of Cu((II))ATSM, yet there are no reports that it confers cardioprotection. We demonstrate that Cu((II))ATSM activates the redox-sensitive transcription factor Nrf2 in human coronary artery smooth muscle cells (HCASMC) and cardiac myocytes (HCM), leading to upregulation of antioxidant defense enzymes. Oral delivery of Cu((II))ATSM in mice induced expression of the Nrf2-regulated enzymes in the heart and aorta...
December 21, 2016: Scientific Reports
https://www.readbyqxmd.com/read/28434374/cardiac-amyloid-imaging-with-18-f-florbetaben-positron-emission-tomography-a-pilot-study
#2
W Phillip Law, William Wang, Peter Moore, Peter Mollee, Arnold Ng
No abstract text is available yet for this article.
March 2017: Amyloid: the International Journal of Experimental and Clinical Investigation
https://www.readbyqxmd.com/read/28432666/optimizing-myocardial-metabolism-for-fluorine-18-fluorodeoxyglucose-positron-emission-tomography-imaging-of-cardiac-inflammation
#3
EDITORIAL
Efstathia Andrikopoulou, Pradeep Bhambhvani
No abstract text is available yet for this article.
April 21, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28430740/low-dose-computed-tomography-scans-with-automatic-exposure-control-for-patients-of-different-ages-undergoing-cardiac-pet-ct-and-spect-ct
#4
Ching-Ching Yang, Bang-Hung Yang, Chun-Yuan Tu, Tung-Hsin Wu, Shu-Hsin Liu
PURPOSE: This study aimed to evaluate the efficacy of automatic exposure control (AEC) in order to optimize low-dose computed tomography (CT) protocols for patients of different ages undergoing cardiac PET/CT and single-photon emission computed tomography/computed tomography (SPECT/CT). METHODS: One PET/CT and one SPECT/CT were used to acquire CT images for four anthropomorphic phantoms representative of 1-year-old, 5-year-old and 10-year-old children and an adult...
April 20, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28430739/downstream-indication-to-revascularization-following-hybrid-cardiac-pet-mri-preliminary-results
#5
Julien Priamo, Dionysos Adamopoulos, Oliver Rager, Angela Frei, Stephane Noble, David Carballo, Osman Ratib, René Nkoulou
BACKGROUND: Hybrid PET/MRI allows the acquisition of both fluorine-18-fluorodeoxyglucose (F-FDG) PET and cardiac magnetic resonance (CMR) during one session. Whether this will result in different referral to coronary revascularization (CR) is unknown. We compared this new hybrid method with all-nuclear/all-CMR methods in the assessment of viable myocardium and in downstream referral to CR. PATIENTS AND METHODS: Overall, 12 patients with rest perfusion defects on a single photon emission computed tomography (SPECT) were recruited for cardiac viability assessment using a PET/MRI device...
April 20, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28429512/tailored-approach-for-management-of-ventricular-tachycardia-in-cardiac-sarcoidosis
#6
Sachin Yalagudri, Ngwe Zin Thu, Soumen Devidutta, Daljeet Saggu, Ajit Thachil, Sridevi Chennapragada, Calambur Narasimhan
INTRODUCTION: Treating ventricular tachycardia (VT) in patients with cardiac sarcoidosis (CS) is challenging as patients present in different phase of the disease (inflammatory, scar or sometimes both). A customized approach to treatment is required for better outcomes. We describe our experience in the management of VT in CS based on the phase of the disease. METHODS AND RESULTS: Patients were considered to have myocardial inflammation if there was an increased myocardial (18) Fluoro Deoxy Glucose (FDG) uptake in PET-CT scan of the chest (n=14)...
April 21, 2017: Journal of Cardiovascular Electrophysiology
https://www.readbyqxmd.com/read/28426162/motion-corrected-simultaneous-cardiac-positron-emission-tomography-and-coronary-mr-angiography-with-high-acquisition-efficiency
#7
Camila Munoz, Radhouene Neji, Gastão Cruz, Andrew Mallia, Sami Jeljeli, Andrew J Reader, Rene M Botnar, Claudia Prieto
PURPOSE: Develop a framework for efficient free-breathing simultaneous whole-heart coronary magnetic resonance angiography (CMRA) and cardiac positron emission tomography (PET) on a 3 Tesla PET-MR system. METHODS: An acquisition that enables nonrigid motion correction of both CMRA and PET has been developed. The proposed method estimates translational motion from low-resolution 2D MR image navigators acquired at each heartbeat and 3D nonrigid respiratory motion between different respiratory bins from the CMRA data itself...
April 20, 2017: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/28418949/initial-experience-with-simultaneous-18f-fdg-pet-mri-in-the-evaluation-of-cardiac-sarcoidosis-and-myocarditis
#8
Kate Hanneman, Michael Kadoch, Henry H Guo, Mehran Jamali, Andrew Quon, Andrei Iagaru, Robert Herfkens
PURPOSE: The purpose of this study was to compare combined PET/MRI with PET/CT and cardiac MRI in the evaluation of cardiac sarcoidosis and myocarditis. METHODS: Ten patients (4 men and 6 women; 56.1 ± 9.6 years old) were prospectively enrolled for evaluation of suspected cardiac sarcoidosis or myocarditis. Written informed consent was obtained. Following administration of 9.9 ± 0.9 mCi F-FDG, patients underwent standard cardiac PET/CT followed by combined PET/MRI using a simultaneous 3-T scanner...
April 17, 2017: Clinical Nuclear Medicine
https://www.readbyqxmd.com/read/28418521/evaluation-of-amyloid-protective-factors-and-alzheimer-disease-neurodegeneration-protective-factors-in-elderly-individuals
#9
Prashanthi Vemuri, David S Knopman, Timothy G Lesnick, Scott A Przybelski, Michelle M Mielke, Jonathan Graff-Radford, Melissa E Murray, Rosebud O Roberts, Maria Vassilaki, Val J Lowe, Mary M Machulda, David T Jones, Ronald C Petersen, Clifford R Jack
Importance: While amyloid and neurodegeneration are viewed together as Alzheimer disease pathophysiology (ADP), the factors that influence amyloid and AD-pattern neurodegeneration may be considerably different. Protection from these ADP factors may be important for aging without significant ADP. Objective: To identify the combined and independent protective factors for amyloid and AD-pattern neurodegeneration in a population-based sample and to test the hypothesis that "exceptional agers" with advanced ages do not have significant ADP because they have protective factors for amyloid and neurodegeneration...
April 17, 2017: JAMA Neurology
https://www.readbyqxmd.com/read/28408703/accuracy-of-rb-82-pet-ct-mpi-with-regadenoson-stress-including-three-year-clinical-outcomes-reporting-present-pet-ct-regadenoson-stress-experience-at-the-va-north-texas
#10
Michael Brophey, Irfan Farukhi, Rosinda Castanon, Rosinda DeLaPena, Ledjona Bradshaw, Subhash Banerjee
The purpose of this study was to determine the clinical accuracy of Rb-82 PET/CT MPI when performed with regadenoson stress in a VA population of patients. Methods: The initial cohort of 480 patients undergoing vasodilator PET MPI with regadenoson stress at our institution from September 2009 through July 2010 were closely tracked for short term outcomes based on correlation with invasive coronary catheterization. Long term outcomes were determined by major adverse cardiac event rates (MACE) based on data extraction from the electronic medical record and grouped by SSS for a three year period...
April 13, 2017: Journal of Nuclear Medicine Technology
https://www.readbyqxmd.com/read/28401505/cardiac-applications-of-pet-mr
#11
REVIEW
Peter J Bergquist, Michael S Chung, Anja Jones, Mark A Ahlman, Charles S White, Jean Jeudy
PURPOSE OF REVIEW: The purpose of this study was to provide an overview of the clinical applications of PET-MR in the setting of cardiac imaging with emphasis on specific scenarios where both techniques together provided added information. RECENT FINDINGS: Synergy of cardiac PET and MR fusion may hold similar promise eliminating ionizing radiation and improving tissue contrast. Future development of new hybrid scanners, use of new imaging tracers, and clinical applications are significant factors which will influence its use...
May 2017: Current Cardiology Reports
https://www.readbyqxmd.com/read/28397369/incidental-primary-mediastinal-choriocarcinoma-diagnosed-by-endobronchial-ultrasound-guided-fine-needle-aspiration-in-a-patient-presenting-with-transient-ischemic-attack-and-stroke
#12
Ivo M B Francischetti, Antonio Cajigas, Mark Suhrland, Joaquim M Farinhas, Samer Khader
We describe a case of a 41-year old male patient with no significant prior medical history who presents with symptoms of Transient Ischemic Attack and stroke. Magnetic Resonance Imaging (MRI) of the brain identified areas of ischemia in the left side, and angiography showed occlusion of the left Medial Cerebral Artery (MCA). Cardiac Transthoracic Echocardiogram (TTE) for stroke evaluation incidentally noted a mediastinal abnormality leading to cancer work-up. Computer Tomography (CT) and (18) F-fluorodeoxyglucose (FDG) PET-CT scan of the chest incidentally revealed an avid 6 cm paraesophagial/subcarinal mass...
April 11, 2017: Diagnostic Cytopathology
https://www.readbyqxmd.com/read/28397181/pet-should-replace-spect-in-cardiac-imaging-for-diagnosis-and-risk-assessment-of-patients-with-known-or-suspected-cad-pro
#13
Jamshid Maddahi, René R Sevag Packard
No abstract text is available yet for this article.
April 10, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28390532/cardiac-applications-of-pet-mr-imaging
#14
REVIEW
Jeffrey M C Lau, Richard Laforest, Felix Nensa, Jie Zheng, Robert J Gropler, Pamela K Woodard
Simultaneous acquisition PET/MR imaging combines the anatomic capabilities of cardiac MR imaging with quantitative capabilities of both PET and MR imaging. Cardiac PET/MR imaging has the potential not only to assess cardiac tumors but also to provide thorough assessment of myocardial ischemia, infarction, and function and specific characterization of cardiomyopathies, such as cardiac sarcoid. In this article, the authors start with a discussion of the technical challenges specific to cardiovascular PET/MR imaging followed by a discussion of the use of PET/MR imaging in various cardiovascular conditions...
May 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28390527/magnetic-resonance-derived-improvements-in-pet-imaging
#15
REVIEW
David S Lalush
Simultaneous PET-MR imaging improves deficiencies in PET images. The primary areas in which magnetic resonance (MR) has been applied to guide PET results are in correction for patient motion and in improving the effects of PET resolution and partial volume averaging. MR-guided motion correction of PET has been applied to respiratory, cardiac, and gross body movements and shown to improve lesion detectability and contrast. Partial volume correction or resolution improvement of PET governed by MR imaging anatomic information improves visualization of structures and quantitative accuracy...
May 2017: Magnetic Resonance Imaging Clinics of North America
https://www.readbyqxmd.com/read/28390040/incidental-extra-cardiac-findings-on-13-nh3-myocardial-perfusion-pet-ct
#16
EDITORIAL
Andrei Iagaru
No abstract text is available yet for this article.
April 7, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28390039/incidental-extra-cardiac-findings-on-13-n-ammonia-myocardial-perfusion-pet-ct
#17
H Kan, F M van der Zant, M Wondergem, R J J Knol
BACKGROUND: The objective of this study was to describe the prevalence of incidental extra-cardiac findings (IECFs) on myocardial perfusion PET/CTs and the prevalence of potentially clinically relevant and clinically irrelevant IECFs, as well as detection rate of previously unknown malignancies. METHODS AND RESULTS: From September 2013 until February 2016, a total of 1397 consecutive patients referred for the evaluation of possible ischemia by (13)NH3 PET/CT were prospectively included in a database...
April 7, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28381081/cardiac-imaging-in-patients-with-acute-or-chronic-heart-failure
#18
Giorgio Faganello, Sara Doimo, Concetta DI Nora, Andrea DI Lenarda
In recent years, imaging techniques have revolutionized the diagnosis of heart failure (HF) and they are indispensable for clinical decision-making in patients with acute and chronic HF. Echocardiography remains a first-line test in HF and continues to provide valuable information on left ventricular and valvular function. However, there is increasing evidence to integrate imaging modalities such as cardiovascular magnetic resonance, positron emission tomography and computed tomography, in the clinical care...
April 4, 2017: Minerva Cardioangiologica
https://www.readbyqxmd.com/read/28378112/automatic-determination-of-cardiovascular-risk-by-ct-attenuation-correction-maps-in-rb-82-pet-ct
#19
Ivana Išgum, Bob D de Vos, Jelmer M Wolterink, Damini Dey, Daniel S Berman, Mathieu Rubeaux, Tim Leiner, Piotr J Slomka
BACKGROUND: We investigated fully automatic coronary artery calcium (CAC) scoring and cardiovascular disease (CVD) risk categorization from CT attenuation correction (CTAC) acquired at rest and stress during cardiac PET/CT and compared it with manual annotations in CTAC and with dedicated calcium scoring CT (CSCT). METHODS AND RESULTS: We included 133 consecutive patients undergoing myocardial perfusion (82)Rb PET/CT with the acquisition of low-dose CTAC at rest and stress...
April 4, 2017: Journal of Nuclear Cardiology: Official Publication of the American Society of Nuclear Cardiology
https://www.readbyqxmd.com/read/28377469/-18-f-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-in-cardiac-implantable-electronic-devices-infection-ready-for-routine-care
#20
EDITORIAL
François Rouzet, Dominique Le Guludec
No abstract text is available yet for this article.
April 2017: Circulation. Cardiovascular Imaging
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