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H Deng, Y Dai, H Lu, S-S Li, L Gao, D-L Zhu
OBJECTIVE: To investigate the relationship between bone metabolic indicators and non-alcoholic fatty liver disease (NAFLD) in healthy middle-aged men. PATIENTS AND METHODS: The bone metabolic indicators of 232 healthy middle-age men with NAFLD (NAFLD group) and 308 healthy controls without fatty liver (Control group) were measured, including non-collagenous osteocalcin, the procollagen type 1 N-terminal propeptide (P1NP), beta-C-terminal telopeptide of type I collagen (β-CTX)...
March 2018: European Review for Medical and Pharmacological Sciences
Zenaida Vazquez-Ruiz, Carmen De la Fuente-Arrillaga, Maira Bes-Rastrollo, Itziar Zazpe, Susana Santiago, Cristina Razquin, Estefanía Toledo, Miguel Ángel Martinez-Gonzalez
INTRODUCTION AND OBJECTIVES: Our aim was to prospectively evaluate the association between egg consumption and dyslipidemia in a Mediterranean cohort. METHODS: We followed-up 13,104 Spanish university graduates for a mean period of 8 years. Dietary habits at baseline were assessed using a validated semi-quantitative 136-item food-frequency questionnaire. Self-reported blood concentrations of total cholesterol, high-density lipoproteins cholesterol (HDL-c) and triglycerides were evaluated according to categories of egg consumption after 6 and 8 years of follow-up...
January 12, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Norma Amador-Licona, Evelin Valeria Moreno-Vargas, Claudia Martinez-Cordero
INTRODUCTION: The daily protein recommendation for adults is 0.8 g/kg/day; however, several studies argue that an intake of 1.0-1.5 g protein/kg/day could benefit the health of the elderly. OBJECTIVE: We evaluated the protein intake and serum lipid levels in elderly patients with hip fracture, determining their correlation with the grip strength in both hands. METHODS: The study included 47 adult patients aged 65-85 years hospitalized for recent hip fracture...
January 10, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
María José Arias Téllez, Johana Patricia Soto-Sánchez, Sergio Gerardo Weisstaub
OBJECTIVE: To evaluate the association of physical fitness (PF) and cardiometabolic risk (CMR) with heart rate recovery time (ΔHRR) in Chilean school aged children. METHODS: Cross-sectional study in 478 6-9 years old children participants. We measured weight, height and abdominal circumference. Fitness was measured using the 6MWT, grip strength and leap forward without impulse tests; PF z-scores were calculated. Heart rate (HR) was monitored and recorded during the 6MWT...
January 10, 2018: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
Kisantini Murugesu, Vikneswaran Murugaiyah, Sultan Ayesh Mohammed Saghir, Mohd Zaini Asmawi, Amirin Sadikun
BACKGROUND: Ethanolic extract of G. procumbens leaves has been previously shown to pos-sess antihyperlipidemic effects. OBJECTIVE: This study was designed to prepare caffeoylquinic acids rich and poor fractions of the ethanol-ic extract using resin column technology and compare their antihyperlipidemic and antioxidant potentials. RESULTS: Among the treatment groups, caffeoylquinic acids rich fraction (F2) and chlorogenic acid (CA, one of the major caffeoylquinic acids) showed potent antihyperlipidemic effects, with significant reduc-tions in total cholesterol (TC), triglycerides (TG), low-density lipoprotein-cholesterol (LDL-C), very low-density lipoprotein-cholesterol (VLDL-C), atherogenic index (AI) and coronary risk index (CRI) (p<0...
March 21, 2018: Current Pharmaceutical Biotechnology
Alexios Verveniotis, Gerasimos Siasos, Evangelos Oikonomou, Vasiliki Tsigkou, Nikolaos Papageorgiou, Marina Zaromitidou, Theodora Psaltopoulou, Georgios Marinos, Spyridon Deftereos, Manolis Vavuranakis, Christodoulos Stefanadis, Athanasios G Papavassiliou, Dimitris Tousoulis
BACKGROUND: Fatty acids are common dietary nutrients particularly in economically developed countries. Research has revealed that omega-3fatty acids exert beneficial effects in the progression of atherosclerosis and cardiovascular disease. Moreover, eicosapentaenoic acid and docosahexaenoic acid possess a number of biological actions which improve cardio-metabolic health. Omega-3 fatty acids display remarkable anti-oxidant, anti-inflammatory, anti-thrombotic and anti-arrythmogenic actions...
March 20, 2018: Current Pharmaceutical Design
Cristian Alvarez, Rodrigo Ramirez-Campillo, Cristian Martinez-Salazar, Angélica Castillo, Francisco Gallardo, Emmanuel Gomes Ciolac
Sedentary overweight or obese adult (age<60 years) women, allocated in type 2 diabetes mellitus (T2DM, n =13), dyslipidemia alone (DYS, n =12), dyslipidemia associated with hyperglycaemia (DYSHG, N=12), or healthy control (CON, n =10) groups, had their lipid, glucose, blood pressure, endurance performance, and anthropometry variables assessed before and after 16 weeks of a thrice-weekly high-intensity interval training (HIIT) program. Triglycerides reduced significantly ( P <0.05) in all groups, and high-density lipoprotein increased ( P <0...
March 21, 2018: International Journal of Sports Medicine
A Samadi, A Gurlek, S N Sendur, S Karahan, F Akbiyik, I Lay
PURPOSE: To assess the plasma oxysterol species 7-ketocholesterol (7-Kchol) and cholestane-3β,5α,6β-triol (chol-triol) as biomarkers of oxidative stress in type 1 and type 2 diabetes mellitus (DM). METHODS: In total, 26 type 1 and 80 type 2 diabetes patients, along with 205 age- and gender-matched healthy controls, were included in this study. Oxysterols were quantified by liquid chromatography coupled with tandem mass spectrometry and N,N-dimethylglycine derivatization...
March 21, 2018: Journal of Endocrinological Investigation
Ratneev Kaur, Tajinder Kaur, Anupam Kaur
PURPOSE: Polycystic ovary syndrome (PCOS) is a complex multifactorial endocrine disorder affecting approximately 5-10% of women of reproductive age. Affected women have menstrual disturbances due to anovulation, infertility, and hyperandrogenism. Ovarian androgen overproduction is the key physiopathologic feature of PCOS. A number of genes encoding major enzymes of the androgen metabolic pathways, such as HSD17B6, CYP19A1, CYP11A1, CYP17A1, and INSR, have been examined. Very few studies have been done in North India...
March 22, 2018: Journal of Assisted Reproduction and Genetics
Atefeh Krouni, Sedighe Forouhari, Bahia Namavarjahromi, Mohammad Hossein Dabbaghmanesh, Arezoo Shayan, Sara Sepasi, Atefeh Zare
Introduction: Hirsutism is a common disorder that has remarkable physical and mental effects on individuals. No appropriate diet has yet specified for individuals with hirsutism. The present study was carried out to examine the effect of high-fibre, low-caloric balanced diet on some related hormone levels in obese or overweight women with hirsutism who had referred to clinics affiliated with Shiraz University of Medical Sciences. Materials and Methods: The present study was a clinical trial that was carried out on 47 obese or overweight women with hirsutism in 2014...
October 2017: Journal of Family Medicine and Primary Care
Gaurav Nepal, Eans T Tuladhar, Keshav Acharya, Aseem Bhattarai, Vijay K Sharma, Mithileshwor Raut, Binod K Yadav
Introduction Cardiovascular diseases are one of the main causes of morbidity and mortality worldwide, atherosclerosis being the principal underlying cause of cardiovascular diseases. Early detection of dyslipidemia and long-term prevention of atherosclerosis by controlling risk factors should begin in young age. The purpose of this study was to assess dyslipidemia and associated cardiovascular risk factors among university students of Nepal. Methods A sample of 280 students aged 17-24 years, were selected randomly from Institute of Medicine, Tribhuvan University...
January 20, 2018: Curēus
Noel Tenyang, Bernard Tiencheu, Hilaire Macaire Womeni
Changes in lipids of herring ( Clupea harengus ) muscle during different smoking methods and 9 days of refrigeration at 4°C were investigated. The proximate analysis of raw herring revealed that the total lipid, the total protein content and the crude ash were 10.20%, 69.43%, and 19.42%, respectively. The results also indicated that during all processing free fatty acids (FFAs) and peroxide value (PV) increased, whereas iodine value (IV) and total triglycerides decreased. The change were more significantly ( p  < ...
March 2018: Food Science & Nutrition
Eric K Ofori, Freda D Intiful, Matilda Asante, George A Asare, Patrick K Adjei, Rebecca K Steele-Dadzie, Anna Amoako-Mensah, Daniel Mensah, Seth K Angmorterh
Cardiovascular diseases (CVDs) are listed as one of the main causes of mortality and morbidity by the World Health Organization. The World Heart Federation lists overweight/obesity, blood lipid profile, and blood pressure as some of the modifiable risk factors to developing CVDs. This study sought to determine the prevalence of some of these modifiable risk factors among University of Ghana students. One hundred and twenty students were sampled for the study. Lipid profile parameters such as high-density lipoprotein (HDL), total cholesterol (TC), and total triglycerides (TG) were measured using the Vitros 5-IFS chemistry analyzer (NY, USA)...
March 2018: Food Science & Nutrition
Aloui Khouloud, Salma Abedelmalek, Hamdi Chtourou, Nizar Souissi
The aim of the study was to investigate the effect of a flavonoid-rich fresh fruit juice on cardiovascular, oxidative stress, and biochemical parameters during the yo-yo intermittent recovery test (YYIRT). Twenty-two healthy males subjects participated in this study divided into two groups: An experimental group (EG: n  = 11) who consumed the antioxidant supplement and a control group (CG: n  = 11). All participants performed two test sessions at 07:00 hr before and after 2 weeks of supplementation with Opuntia ficus-indica juice...
March 2018: Food Science & Nutrition
Jian Li, Mengyang Liu, Haiyang Yu, Wei Wang, Lifeng Han, Qian Chen, Jingya Ruan, Shaoshi Wen, Yi Zhang, Tao Wang
Objective: Mangiferin (MGF) is a natural xanthone, with regulation effect on lipid metabolism. However, the molecular mechanism remains unclear. We purposed after oral administration, MGF is converted to its active metabolite(s), which contributes to the effects on lipid metabolism. Methods: KK-Ay mice were used to validate the effects of MGF on lipid metabolic disorders. Liver biochemical indices and gene expressions were determined. MGF metabolites were isolated from MGF administrated rat urine. Mechanism studies were carried out using HepG2 cells treated by MGF and its metabolite with or without inhibitors or small interfering RNA (siRNA)...
2018: Frontiers in Pharmacology
Nathan D Roe, Michal K Handzlik, Tao Li, Rong Tian
It is increasingly recognized that synthesis and turnover of cardiac triglyceride (TG) play a pivotal role in the regulation of lipid metabolism and function of the heart. The last step in TG synthesis is catalyzed by diacylglycerol:acyltransferase (DGAT) which esterifies the diacylglycerol with a fatty acid. Mammalian heart has two DGAT isoforms, DGAT1 and DGAT2, yet their roles in cardiac metabolism and function remain poorly defined. Here, we show that inactivation of DGAT1 or DGAT2 in adult mouse heart results in a moderate suppression of TG synthesis and turnover...
March 21, 2018: Scientific Reports
Guo-Ming Zhang, Shu-Mei Bai, Gao-Ming Zhang, Xiao-Bo Ma, Hemant Goyal
BACKGROUND We aimed to predict the abnormal LDL level by using TG, TC, HDL, and non-HDL in this study. MATERIAL AND METHODS Triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) data were obtained from the Laboratory Information System (LIS) for 4 years (Oct 1, 2013 to Sept 30, 2017) from among 34 270 healthy Chinese patients at Shuyang People's Hospital. TG, TC, HDL, and LDL (direct clearance method) were measured using a TBA2000FR biochemical analyzer...
March 22, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Jung-Yoon Heo, Ji-Eun Kim, Yongwook Dan, Yong-Woon Kim, Jong-Yeon Kim, Kyu Hyang Cho, Young Kyung Bae, Seung-Soon Im, Kwang-Hyeon Liu, In-Hwan Song, Jae-Ryong Kim, In-Kyu Lee, So-Young Park
Clusterin is a secretory glycoprotein that is involved in multiple physio-pathological processes, including lipid metabolism. Previous studies have shown that clusterin prevents hepatic lipid accumulation via suppression of sterol regulatory element-binding protein (SREBP) 1. In this study, we examined the role of clusterin in renal lipid accumulation in clusterin knockout mice and NRK52e tubular epithelial cells. Clusterin deficiency increased the expression of SREBP1 and its target genes, and decreased malonyl CoA decarboxylase protein levels in the kidney...
March 21, 2018: Journal of Endocrinology
Sang Bae Lee, Chul Woo Ahn, Byoung Kwon Lee, Shinae Kang, Ji Sun Nam, Ji Hong You, Min Jin Kim, Min Kyung Kim, Jong Suk Park
BACKGROUND: The triglyceride glucose (TyG) index has been suggested as a simple surrogate marker of insulin resistance. However, there are limited data regarding the association between the TyG index and arterial stiffness in adults. Therefore, we evaluated the relationship between the TyG index and arterial stiffness as measured based on brachial ankle pulse wave velocity (baPWV) in Korean adults. METHODS: A total of 3587 subjects were enrolled in this study. Anthropometric and cardiovascular risk factors were measured...
March 21, 2018: Cardiovascular Diabetology
Daniela Menichini, Monica Longo, Fabio Facchinetti
Maternal obesity is an adverse factor that affects the intrauterine environment during critical periods of fetal developmental causing adverse lifelong effects on offspring health. Several different interventions have been performed in animal models of obesity to ameliorate maternal conditions and consequently reduce the adverse effects on offspring. Our aim was to critically review studies involving murine models of obesity induced by high fat diet (HFD), assessing maternal outcomes during pregnancy and the related offspring conditions...
March 21, 2018: Journal of Maternal-fetal & Neonatal Medicine
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