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https://www.readbyqxmd.com/read/27921357/interrelationship-between-mini-mental-state-examination-scores-and-biochemical-parameters-in-patients-with-mild-cognitive-impairment-and-alzheimer-s-disease
#1
Ramasamy Vasantharekha, Hannah P Priyanka, Thangavel Swarnalingam, Avathvadi Venkatesan Srinivasan, Srinivasan ThyagaRajan
AIM: The aim of the present study was to provide first-hand information about the prevalence of mild cognitive impairment (MCI) and Alzheimer's disease (AD) in Tamil Nadu, a southern state in India, and examine if there exists a relationship between cognitive functions and biochemical parameters in these patients. METHODS: Surveys were collected from adults, older men and women (n = 3126) from different regions of Tamil Nadu, which were followed up after 12 months for 1337 participants...
December 6, 2016: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/27921351/the-effect-of-combined-inositol-hexakisphosphate-and-inositol-supplement-in-streptozotocin-induced-type-2-diabetic-rats
#2
Shadae R Foster, Felix O Omoruyi, Juan Bustamante, Ruby L A Lindo, Lowell L Dilworth
Inositol hexakisphosphate (IP6) and inositol both regulate insulin secretion, but their combined use in the management of diabetes deserves investigation. The combined effects of IP6 and inositol supplementation were investigated in streptozotocin-induced type 2 diabetic rats. The following groups of rats were studied for 8 weeks: non-diabetic control, non-diabetic high-fat diet control, diabetic untreated, diabetic rats treated with the combination of IP6 and inositol (650 mg/kg bw) and diabetic rats treated with glibenclamide (10 mg/kg bw)...
December 6, 2016: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/27921043/metabolic-vascular-syndrome-new-insights-into-a-multidimensional-network-of-risk-factors-and-diseases
#3
REVIEW
Gerhard H Scholz, Markolf Hanefeld
BACKGROUND: Since 1981, we have used the term metabolic syndrome to describe an association of a dysregulation in lipid metabolism (high triglycerides, low high-density lipoprotein cholesterol, disturbed glucose homeostasis (enhanced fasting and/or prandial glucose), gout, and hypertension), with android obesity being based on a common soil (overnutrition, reduced physical activity, sociocultural factors, and genetic predisposition). We hypothesized that main traits of the syndrome occur early and are tightly connected with hyperinsulinemia/insulin resistance, procoagulation, and cardiovascular diseases...
October 2016: Visceral Medicine
https://www.readbyqxmd.com/read/27921025/prostate-specific-antigen-rising-in-iranian-men-in-correlation-with-body-mass-index-fasting-blood-sugar-and-blood-lipid-profile
#4
Davood Arab, Arash Ardestani Zadeh, Majid Mirmohammadkhani, Azadeh Beiglarzadeh
BACKGROUND: Prostate-specific antigen (PSA) is a serine protease that is secreted by prostate cells and it is useful as a tumor marker for prostate cancer. OBJECTIVES: In this study, the relationship between some of metabolic factors and serum PSA level was investigated. MATERIALS AND METHODS: In this cross-sectional study, patients with urinary symptoms or for screening of the prostate cancer (after 50 years of age or 40 years with a family history of prostate cancer), were evaluated...
October 2016: Journal of Nephropathology
https://www.readbyqxmd.com/read/27920819/co-administration-of-metformin-and-n-acetylcysteine-with-dietary-control-improves-the-biochemical-and-histological-manifestations-in-rats-with-non-alcoholic-fatty-liver
#5
Naglaa Mohamed El-Lakkany, Sayed Hassan Seif El-Din, Abdel-Nasser Abdel-Aal Sabra, Olfat Ali Hammam, Fatma Abdel-Latif Ebeid
Non-alcoholic fatty liver disease (NAFLD) is a burgeoning health problem that affects 1/3 of the adult population and an increasing number of children in developed countries. Oxidative stress and insulin resistance are the mechanisms that seem to be mostly involved in its pathogenesis. This study was conceived in a NAFLD rat model to evaluate the efficacy of both metformin (MTF) and N-acetylcysteine (NAC) with dietary control on biochemical and histologic liver manifestations. Rats were classified into nine groups; normal (I), NAFLD-induced by feeding high-fat diet (HFD; II) for 12 weeks, NAFLD switched to regular diet (RD; III), NAFLD-HFD or -RD treated with MTF in a dose of 150 mg/kg (IV, V), NAC in a dose of 500 mg/kg (VI, VII) or MTF+NAC (VIII, IX) respectively for 8 weeks...
October 2016: Research in Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27920508/impact-of-whole-body-electromyostimulation-on-cardiometabolic-risk-factors-in-older-women-with-sarcopenic-obesity-the-randomized-controlled-formosa-sarcopenic-obesity-study
#6
Katharina Wittmann, Cornel Sieber, Simon von Stengel, Matthias Kohl, Ellen Freiberger, Franz Jakob, Michael Lell, Klaus Engelke, Wolfgang Kemmler
BACKGROUND: Sarcopenic obesity (SO) is characterized by a combination of low muscle and high fat mass with an additive negative effect of both conditions on cardiometabolic risk. The aim of the study was to determine the effect of whole-body electromyostimulation (WB-EMS) on the metabolic syndrome (MetS) in community-dwelling women aged ≥70 years with SO. METHODS: The study was conducted in an ambulatory university setting. Seventy-five community-dwelling women aged ≥70 years with SO living in Northern Bavaria, Germany, were randomly allocated to either 6 months of WB-EMS application with (WB-EMS&P) or without (WB-EMS) dietary supplementation (150 kcal/day, 56% protein) or a non-training control group (CG)...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27920277/the%C3%A2-diffuse%C3%A2-reduction%C3%A2-of%C3%A2-spleen%C3%A2-density-%C3%A2-an%C3%A2-indicator%C3%A2-of%C3%A2-severe%C3%A2-acute%C3%A2-pancreatitis
#7
Guangdong Shao, Yanmei Zhou, Zengfu Song, Maitao Jiang, Xiaoqian Wang, Xiangren Jin, Bei Sun, Xuewei Bai
BACKGROUND: We observed that acute pancreatitis (AP) was associated with diffuse reduction of spleen density (DROSD) in some patients. Furthermore, the condition of these patients was more serious, and the potential relationship between DROSD and structural and functional injury of the spleen remained unclear. Therefore, we performed a preliminary exploration of these factors. METHODS: We analysed pertinent clinical data for AP patients with normal spleen density (control group) and for those with DROSD (reduction group) at the First Affiliated Hospital of Harbin Medical University (2013...
December 5, 2016: Bioscience Reports
https://www.readbyqxmd.com/read/27919931/low-mt-co1-in-monocytes-and-microvesicles-is-associated-with-outcome-in-patients-with-coronary-artery-disease
#8
Paul Holvoet, Maarten Vanhaverbeke, Katarzyna Bloch, Pieter Baatsen, Peter Sinnaeve, Stefan Janssens
BACKGROUND: Cytochrome oxidase (COX) IV complex regulates energy production in mitochondria. Impaired COX gene expression is related to obesity and type 2 diabetes mellitus, but whether it is directly related to the incidence of cardiovascular events is unknown. We investigated whether COX gene expression in monocytes is predictive for cardiovascular events in coronary artery disease patients. To avoid monocyte isolation from fresh blood, we then aimed to validate our findings in monocyte-derived microvesicles isolated from plasma...
December 5, 2016: Journal of the American Heart Association
https://www.readbyqxmd.com/read/27919543/maternal-plasma-polyunsaturated-fatty-acid-levels-during-pregnancy-and-childhood-lipid-and-insulin-levels
#9
A J Vidakovic, V W V Jaddoe, T Voortman, H Demmelmair, B Koletzko, R Gaillard
BACKGROUND AND AIMS: Maternal polyunsaturated fatty acid (PUFA) levels are associated with cord blood lipid and insulin levels. Not much is known about the influence of maternal PUFAs during pregnancy on long-term offspring lipid and insulin metabolism. We examined the associations of maternal plasma n-3 and n-6 PUFA levels during pregnancy with childhood lipid and insulin levels. METHODS AND RESULTS: In a population-based prospective cohort study, among 3230 mothers and their children, we measured maternal second trimester n-3 and n-6 PUFA plasma levels...
October 12, 2016: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
https://www.readbyqxmd.com/read/27919362/the-effect-of-omega-3-carboxylic-acids-on-apolipoprotein-ciii-containing-lipoproteins-in-severe-hypertriglyceridemia
#10
Allyson M Morton, Jeremy D Furtado, Jane Lee, William Amerine, Michael H Davidson, Frank M Sacks
BACKGROUND: Lipoprotein subspecies containing apoCIII adversely affect cardiovascular disease (CVD) risk; for example, low density lipoprotein (LDL) with apoCIII is a stronger CVD predictor than LDL without apoCIII. The Epanova for Lowering Very High Triglycerides (EVOLVE) trial showed that Epanova (omega-3 carboxylic acids [OM3-CA]) significantly lowered TG and apoCIII but raised LDL-C. However, it is unknown what subspecies of LDL were affected by treatment. OBJECTIVE: To determine how lipoprotein subspecies are affected by omega-3 fatty acid treatment, we studied the effect of OM3-CA on apoCIII concentrations in high density lipoprotein (HDL), LDL, and very low density lipoprotein (VLDL) and on the concentrations of subspecies of HDL, LDL, and VLDL that contain or do not contain apoCIII...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27919359/association-of-triglyceride-to-high-density-lipoprotein-cholesterol-ratio-to-cardiorespiratory-fitness-in-men
#11
Gloria Lena Vega, Scott M Grundy, Carolyn E Barlow, David Leonard, Benjamin L Willis, Laura F DeFina, Stephen W Farrell
BACKGROUND: Both triglyceride-to-high density lipoprotein cholesterol (TG/HDL-C) and cardiorespiratory fitness (CRF) impart risk for all-cause morbidity and mortality independently of conventional risk factors. OBJECTIVE: To determine prevalence and/or incidence of high TG/HDL-C ratio in men with low CRF. METHODS: Clinical characteristics and CRF were used to determine prevalence of a TG/HDL-C ratio ≥ 3.5 (high ratio) in 13,954 men of the Cooper Center Longitudinal Study...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27919357/lipid-phenotype-and-heritage-pattern-in-families-with-genetic-hypercholesterolemia-not-related-to-ldlr-apob-pcsk9-or-apoe
#12
Estíbaliz Jarauta, María Rosario Pérez-Ruiz, Sofia Pérez-Calahorra, Rocio Mateo-Gallego, Ana Cenarro, Montserrat Cofán, Emilio Ros, Fernando Civeira, Maria Teresa Tejedor
BACKGROUND: A substantial proportion of individuals clinically diagnosed as familial hypercholesterolemia (FH) do not carry pathogenic mutations in candidate genes. Whether in them the high cholesterol trait is transmitted monogenically has not been studied. OBJECTIVES: We assessed the inheritance pattern, penetrance, and expression of high low-density lipoprotein (LDL)-cholesterol (LDLc) in families with genetic hypercholesterolemia (GH) without known causative mutations (non-FH-GH)...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27919353/dyslipidemia-according-to-gender-and-race-the-brazilian-longitudinal-study-of-adult-health-elsa-brasil
#13
Raul D Santos, Isabela M Bensenor, Alexandre C Pereira, Paulo A Lotufo
BACKGROUND: There is little information regarding lipid profiles of racially mixed populations. Differently from other Latin American countries, the proportion of African ancestry is much higher in Brazil. OBJECTIVE: Verify whether there are differences in the lipid profile between black and white subjects and if people with mixed ancestry have a pattern more closely resembling whites or blacks. METHODS: A total of 15,105 civil servants aged 35-74 years from the ELSA-Brasil study had their fasting lipid profile determined...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27919352/impact-of-a-1-year-lifestyle-modification-program-on-plasma-lipoprotein-and-pcsk9-concentrations-in-patients-with-coronary-artery-disease
#14
Marjorie Boyer, Valérie Lévesque, Paul Poirier, André Marette, Patrick Mathieu, Jean-Pierre Després, Éric Larose, Benoit J Arsenault
BACKGROUND: Patients with coronary artery disease (CAD) are characterized by an impaired cardiometabolic risk profile including high levels of atherogenic apolipoprotein (apo) B-containing lipoprotein levels. Genetic studies have highlighted a critical role for proprotein convertase subtilisin/kexin type 9 (PCSK9) in lipoprotein metabolism and CAD risk. OBJECTIVE: To determine whether improving dietary quality and increasing physical activity levels improve parameters of the cardiometabolic risk profile such as plasma apoB and PCSK9 levels in patients with CAD...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27919344/jcl-roundtable-risk-evaluation-and-mitigation-strategy
#15
REVIEW
W Virgil Brown, Dean A Bramlet, Joyce L Ross, James A Underberg
Many factors enter into the decision by the Food and Drug Administration (FDA) to approve a new drug for use by physicians and other health care providers in treating diseases. Initially, the FDA authority was restricted to issues of safety and only later did the documentation of efficacy become part of the review process required for approval. However, all drugs have the potential for causing harm at some dose level to all and at lower doses in certain patients with vulnerability to the particular pharmacology of the agent...
November 2016: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/27919279/height-correlates-with-dyslipidemia-in-non-overweight-middle-aged-japanese-men
#16
Yuji Shimizu, Hiroyuki Yoshimine, Mako Nagayoshi, Koichiro Kadota, Kensuke Takahashi, Kiyohiro Izumino, Kenichiro Inoue, Takahiro Maeda
BACKGROUND: Our previous study showed that height is inversely associated with the risk of stroke in middle-aged Japanese men, particularly in those with a low body mass index (BMI). Since height is regarded as a surrogate maker of childhood social and physical condition, while BMI may reflect primarily on the current physical condition, a detailed analysis of those with a lower BMI may elucidate the effects of childhood conditions. On the other hand, dyslipidemia is recognized as a prominent risk factor for cardiovascular disease...
December 6, 2016: Journal of Physiological Anthropology
https://www.readbyqxmd.com/read/27919218/a-glycemic-threshold-of-90-mg-dl-promotes-early-signs-of-atherosclerosis-in-apparetly-healthy-overweight-obese-subjects
#17
Marco Matteo Ciccone, Francesca Cortese, Michele Gesualdo, Ilaria Donvito, Santa Carbonara, Giovanni De Pergola
BACKGROUND: Alterations of glucose metabolism represent well known risk factors for the atherosclerotic process and then for cardiovascular disease. OBJECTIVE: to investigate the association between fasting glucose and early signs of atherosclerosis, by means of carotid intima-media thickness (c-IMT) in a population of apparently healthy overweight/obese subjects. In addition, we evaluated the possible existence of a glycemic threshold above which the risk of atherosclerosis significantly increases...
December 5, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/27918674/mir-224-affects-mammary-epithelial-cell-apoptosis-and-triglyceride-production-by-downregulating-acadm-and-aldh2-genes
#18
Binglei Shen, Qiqi Pan, Yuwei Yang, Yan Gao, Xin Liu, Wei Li, Yunsheng Han, Xue Yuan, Yongli Qu, Zhihui Zhao
MicroRNAs (miRNAs) are small noncoding RNA molecules that involve in various biological functions by regulating the expressions of target genes. In recent years, many researchers have demonstrated that miR-224 played an important role in regulating lipid metabolism. Therefore, in this study, the target genes of miR-224 were verified and the regulatory role of miR-224 was confirmed in lipid metabolism. In this study, bioinformatics methods were used for primarily predicting the target gene of miR-224 and dual-luciferase reporter system was used for further verify the relationship between miR-224 and its target gene...
December 5, 2016: DNA and Cell Biology
https://www.readbyqxmd.com/read/27918207/gemigliptin-ameliorates-western-diet-induced-metabolic-syndrome-in-mice
#19
Seung Hee Choi, Jaechan Leem, Sungmi Park, Chong-Kee Lee, Keun-Gyu Park, In-Kyu Lee
Dipeptidyl peptidase 4 (DPP-4) inhibitors are widely used antihyperglycemic agents for type 2 diabetes mellitus. Recently, increasing attention has been focused on the pleiotropic actions of DPP-4 inhibitors. The aim of the present study was to examine whether gemigliptin, a recently developed DPP-4 inhibitor, could ameliorate features of metabolic syndrome. Mice were fed a Western diet (WD) for 12 weeks and were subsequently divided into 2 groups: mice fed a WD diet alone or mice fed a WD diet supplemented with gemigliptin for an additional 4 weeks...
September 4, 2016: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/27918086/combined-therapy-with-swimming-exercise-and-a-diet-supplemented-with-diphenyl-diselenide-is-effective-against-age-related-changes-in-the-hepatic-metabolism-of-rats
#20
Suélen O Heck, Bruna C W Fulco, Caroline B Quines, Carla E S Oliveira, Marlon R Leite, José L Cechella, Cristina W Nogueira
Aging is characterized by a widespread loss of homeostasis in biological systems and is accompanied by pathophysiological changes including the liver injury. The aim of the present study was to investigate the effects of the combined therapy with swimming exercise (20 min session, five days/week during four weeks) and a diet supplemented with 1 ppm of (PhSe)2 on the hepatic metabolic alterations caused by aging in rats. In this study, male old Wistar rats had an increase in the epididymal fat relative weight, disturbances in the activities of hepatic enzymes associated to the glucose homeostasis, higher hepatic triglyceride content and higher activity of the plasma alanine aminotransferase (ALT) and aspartate aminotransferase (AST)...
December 5, 2016: Journal of Cellular Biochemistry
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