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Ingrid Felicidade, Daniele Sartori, Susan L M Coort, Simone Cristine Semprebon, Andressa Megumi Niwa, Gláucia Fernanda Rocha D'Epiro, Bruna Isabela Biazi, Lilian Areal Marques, Chris T Evelo, Mário Sérgio Mantovani, Lúcia Regina Ribeiro
BACKGROUND/AIMS: Compared with non-obese individuals, obese individuals commonly store more vitamin D in adipose tissue. VDR expression in adipose tissue can influence adipogenesis and is therefore a target pathway deserving further study. This study aims to assess the role of 1,25(OH)2D3 in human preadipocyte proliferation and differentiation. METHODS: RTCA, MTT, and trypan blue assays were used to assess the effects of 1,25(OH)2D3 on the viability, proliferation, and adipogenic differentiation of SGBS cells...
July 17, 2018: Cellular Physiology and Biochemistry
Lea Katalinic, Branimir Krtalic, Bojan Jelakovic, Nikolina Basic-Jukic
BACKGROUND/AIMS: There is a growing body of evidence that the long-term hemodialysis (HD) treatment leads to disturbances of carnitine homeostasis but the results of L-carnitine supplementation in HD patients have been conflicting. In the present prospective study, we investigated the effectiveness of intravenous L-carnitine in mitigating dialysis-related protein-energy wasting (PEW) based on pre-treatment albumin levels. METHODS: Fifty patients (46% male, mean age 63±18...
July 17, 2018: Kidney & Blood Pressure Research
Roger F Butterworth, Ali Canbay
BACKGROUND: Non-alcoholic fatty liver disease (NAFLD) is the leading chronic hepatic condition worldwide and new approaches to management and treatment are limited. SUMMARY: L-ornithine L-aspartate (LOLA) has hepatoprotective properties in patients with fatty liver of diverse etiology and results of a multicenter randomized clinical trial reveal that 12 weeks treatment with oral LOLA (6-9 g/d) results in a dose-related reduction in activities of liver enzymes and triglycerides together with significant improvements of liver/spleen CT ratios...
July 17, 2018: Digestive Diseases
Jong Bong Lee, Atheer Zgair, Jed Malec, Tae Hwan Kim, Min Gi Kim, Joseph Ali, Chaolong Qin, Wanshan Feng, Manting Chiang, Xizhe Gao, Gregory Voronin, Aimie E Garces, Chun Long Lau, Ting-Hoi Chan, Amy Hume, Tecashanell M McIntosh, Fadi Soukarieh, Mohammed Al-Hayali, Elena Cipolla, Hilary M Collins, David M Heery, Beom Soo Shin, Sun Dong Yoo, Leonid Kagan, Michael J Stocks, Tracey D Bradshaw, Peter M Fischer, Pavel Gershkovich
The intestinal lymphatic system plays an important role in the pathophysiology of multiple diseases including lymphomas, cancer metastasis, autoimmune diseases, and human immunodeficiency virus (HIV) infection. It is thus an important compartment for delivery of drugs in order to treat diseases associated with the lymphatic system. Lipophilic prodrug approaches have been used in the past to take advantage of the intestinal lymphatic transport processes to deliver drugs to the intestinal lymphatics. Most of the approaches previously adopted were based on very bulky prodrug moieties such as those mimicking triglycerides (TG)...
July 14, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Mary Frances Lopez, Lingyun Zheng, Ji Miao, Reddy Gali, Grzegorz Gorski, Joel N Hirschhorn
Newborns with intrauterine growth-restriction are at increased risk of mortality and life-long co-morbidities. Insulin-like growth factor-II (IGF2) deficiency in humans as well as in mice leads to intrauterine growth restriction and decreased neonatal glycogen stores. The present study aims to further characterize the metabolic and transcriptional consequences of Igf2 deficiency in the newborn. We found that, despite being born significantly smaller than their wild-type (Igf2+/+ ) littermates, brain size was preserved in Igf2 knockout (Igf2-/- ), consistent with nutritional deficiency...
July 17, 2018: American Journal of Physiology. Endocrinology and Metabolism
Duan Li, Liwei Guo, Baoguo Deng, Min Li, Tingting Yang, Fan Yang, Zhijun Yang
Sterol regulatory element binding protein‑1c (SREBP‑1c), which serves an essential role in the process of fat synthesis, is a key adjustment factor that regulates the dynamic balance of lipid metabolism. SREBP‑1c activates the transcription of multiple genes encoding for enzymes involved in the synthesis of triglycerides (TG) and fatty acids (FA) and accelerates lipid synthesis. Previous analysis indicated that long non‑coding RNA HCV regulated 1 (lncHR1) participates in lipid metabolism in vivo and regulates the level of SREBP‑1c protein...
July 16, 2018: Molecular Medicine Reports
Yanli Wang, Peng Zhang, Xingli Su, Qi Yu, Yulong Chen, Hua Guan, Enqi Liu, Jianglin Fan
The aim of the present study was to establish a non‑alcoholic fatty liver disease (NAFLD) model using cholesterol‑fed rabbits and to investigate whether endoplasmic reticulum stress (ERS) serves a role in the pathogenesis of NAFLD. A total of 20 male rabbits were randomly divided into 3 groups: Those fed a normal chow diet, a high cholesterol diet (HCD) or a high fat and high cholesterol diet (HFCD) for 12 weeks. Total cholesterol, triglycerides and free fatty acids of plasma and the liver were measured...
July 6, 2018: Molecular Medicine Reports
Jiao Nie, Chang-Ping Li, Jue-Hong Li, Xia Chen, Xiaoling Zhong
The prevalence of non-alcoholic fatty liver disease (NAFLD) has been increasing in recent years. Previous studies have suggested that micro (mi)RNAs may be involved in the pathogenesis of NAFLD. To investigate the role of miRNAs in rat NAFLD, a total of 16 male Sprague Dawley rats were randomly divided into a control group and a model group. Rats in the control group were fed a normal diet for 12 weeks, whereas the rats in the model group were fed a high‑fat and high‑sugar diet for 12 weeks. Following this, the animals were sacrificed and liver tissues were rapidly removed to investigate the severity of NAFLD...
July 9, 2018: Molecular Medicine Reports
Li-Ping Han, Bei Sun, Chun-Jun Li, Yun Xie, Li-Ming Chen
Toll‑like receptor 4 (TLR4)‑mediated immune and inflammatory signaling serves a pivotal role in the pathogenesis of nonalcoholic fatty liver disease (NAFLD). Our previous study demonstrated that celastrol treatment was able to improve hepatic steatosis and inhibit the TLR4 signaling cascade pathway in type 2 diabetic rats. The present study aimed to investigate the effects of celastrol on triglyceride accumulation and inflammation in steatotic HepG2 cells, and the possible mechanisms responsible for the regulation of cellular responses following TLR4 gene knockdown by small interfering RNA (siRNA) in vitro...
July 12, 2018: International Journal of Molecular Medicine
Klaus Wasseroth, Udo Barth, Roland Albrecht, Volker Rahms, Frank Meyer
INTRODUCTION: Chylous complications, which occur also in the profile of vascularsurgical interventions with considerable frequency, are challenging with regard to their adequate management. Aim & method: Compact short overview on epidemiological, classifying, symptomatic, diagnostic and therapeutic aspects of chylous complications in vascular surgery, based on i) own clinical experiences, ii) a current selection of relevant scientific references and iii) representative case reports from clinical practice...
May 16, 2018: Polski Przeglad Chirurgiczny
Mohsen Mazidi, Nitin Shivappa, Michael D Wirth, James R Hebert, Dimitri P Mikhailidis, Andre Pascal Kengne, Maciej Banach
BACKGROUND AND AIMS: We investigated the association between Dietary Inflammatory Index (DII® ) scores and cardio-metabolic risk factors singly and in combination as metabolic syndrome (MetS). METHODS: We used data from participants selected from the US National Health and Nutrition Examination Survey (NHANES). Analyses were restricted to participants with data available on dietary intake, biochemical data, and anthropometric measurements from 2005 to 2012. Statistical analyses used the SPSS® Complex Samples v22...
February 15, 2018: Atherosclerosis
Priscila Ribas de Farias Costa, Sanjay Kinra, Vânia D'Almeida, Ana Marlúcia Oliveira Assis
INTRODUCTION: There is evidence of associations between high serum homocysteine (Hcy) and cysteine (Cys) levels and changes in the lipid profile of adults; however, little information is available with respect to these associations in the pediatric age group. OBJECTIVE: To identify the effect of high baseline serum Hcy and Cys levels, alone or in conjunction, on the lipid profile of children and adolescents over a 12-month follow-up period. METHODS: A cohort study involving 540 boys and girls of 7-15 years of age was conducted over 12 months...
October 2017: Clinical Nutrition ESPEN
Didi Huang, Zhicheng Liu, Bin Xu, Jinhong Yuan
OBJECTIVE: To explore the effect of acupuncture and moxibustion on severe obesity complicated with hyperlipidemia in different genders and their comprehensive effect, lipid indexes, and obesity indexes. METHODS: A total of 264 patients of severe obesity complicated with hyperlipidemia were assigned into a male group (106 cases) and a female group (158 cases).According to their clinical symptoms and patterns, acupuncture and moxibustion differentiation therapies were applied for stomach and intestine heat type, spleen deficiency and dampness resistance type, phlegm-dampness internal resistance type, liver depression and spleen deficiency type, spleen and kidney yang deficiency type and yin deficiency and blood stasis type.The obesity indexes were weight (W), obesity degree (A), body mass index (BMI) and body fat percentage (F); the blood lipid indexes were total cholesterol (TC),triglyceride (TG),low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C)...
July 12, 2018: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
Ting Bao, Han-Wei Yang, You-Juan Wang, Huai-Rong Tang, Yan Huang, Lin-Na Wu
OBJECTIVE: To determine component changes of metabolic syndrome in pre-elderly people with healthy obese phenotype. METHODS: A total of 1 686 adults aged between 45-59 yr. who underwent health examinations from 2010 to 2016 in West China Hospital of Sichuan University participated in this study. The participants had healthy obese phenotype at the baseline but no history of diabetes,high blood pressure,high cholesterol and cardiovascular disease. Component changes of metabolic syndrome (MS) and associated factors over the seven-year period were analysed using logistic regression modeling...
May 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Yi-Ting Wang, Rui-Kun Guo, Zhi-Cheng Li, Rui Zhang, Li Li, Han-Yu Li, Jun-Lin Zhang, Qian-Qian Han, Fang Liu
OBJECTIVE: To investigate the levels of serum soluble CD36 (sCD36) in patients of diabetes mellitus (DM) with chronic kidney disease (CKD),and to analyze its correlation with clinical indicators. METHODS: A total of 161 patients with CKD were enrolled in this study. The patients were divided into two groups according to whether they had DM or not: DM+CKD group and non-DM CKD group. The levels of carotid intima-media thickness (IMT) and the combination of atherosclerotic plaques were measured by color Doppler ultrasonography...
May 2018: Sichuan da Xue Xue Bao. Yi Xue Ban, Journal of Sichuan University. Medical Science Edition
Kai Wu, Ying Cai
BACKGROUND: Cognitive impairment, significantly reducing processing speed and executive function, is the critical consequence of cerebral small vessel disease (SVD), in which genetic variations have been studied. In this study, we explore the role of SNP43 (G/A) and SNP63 (C/T) polymorphism in the CAPN10 on cognitive impairment process in cerebral SVD. METHODS: Cerebral SVD patients (n = 224) and healthy controls (n = 187) were recruited. The relationship between frequency distribution of SNP43 (G/A) and SNP63 (T/C) genotype and allele in CAPN10 gene, and cognitive impairment was examined...
July 16, 2018: Journal of Clinical Laboratory Analysis
Sven Speerforck, F Dodoo-Schittko, S Brandstetter, C Apfelbacher, U Hapke, F Jacobi, H J Grabe, S E Baumeister, G Schomerus
BACKGROUND: Major depressive disorder (MDD) and bipolar disorder are associated with certain cardiovascular risk factors (CVRFs), but it is unclear whether they are associated with unfavourable changes of clinically manifest CVRFs over time. METHODS: We used baseline and 12-year follow-up (n = 1887) data from the German Health Interview and Examination Survey 1998. Multivariable linear regression models assessed associations between lifetime CIDI-diagnosed mood disorders at baseline and continuous risk factor-related outcomes (blood pressure, HbA1c, LDL-C, HDL-C, triglycerides, BMI) at follow-up...
July 16, 2018: European Archives of Psychiatry and Clinical Neuroscience
Ahmed A Saleh, Mohammed A El-Magd
This study was conducted to investigate the growth modulatory effects of dietary supplementation with silver nanoparticles (Ag NPs) and Ag nitrate on broiler chickens. Thirty 15-day-old chicks were equally divided into the control group (fed basal diets), the Ag-nano group (fed basal diets supplemented with 50 ppm/kg of Ag NPs for 12 d), and the Ag nitrate group (fed basal diets supplemented with 100 ppm/kg Ag nitrate for 12 days). Chicks fed Ag NPs showed increased body weight gain and muscle weight, improved feed efficiency, and increased ash digestibility, while Ag digestibility tend to increase but not significant...
July 17, 2018: Environmental Science and Pollution Research International
Eleni Asprouli, IoannaPanagiota Kalafati, Aikaterini Sakellari, Sotirios Karavoltsos, John Vlachogiannakos, Konstantinos Revenas, Alexander Kokkinos, Manos Dassenakis, George V Dedoussis, Nick Kalogeropoulos
Nonalcoholic fatty liver disease (NAFLD) is considered as the hepatic manifestation of metabolic syndrome. Its global prevalence is estimated between 25 and 45%, occurring mainly in overweight individuals with unhealthy dietary habits and low levels of physical activity. Many studies have investigated the association of trace elements with liver diseases, though not with NAFLD. In this work, we investigated trace element levels in plasma of patients and not-patients and their possible association with various stages of the disease...
July 16, 2018: Biological Trace Element Research
Shigemasa Tani, Rei Matsuo, Naoya Matsumoto
It has been demonstrated that regular fish consumption is associated with a reduced mortality from atherosclerotic cardiovascular disease (ASCVD). However, data are scarce regarding the correlation between the changes in the serum eicosapentaenoic acid/arachidonic acid (EPA/AA) ratio associated with regular fish consumption and the changes in the serum lipid profile variables. This study was designed as a hospital-based longitudinal study to investigate the relationship between the changes in the serum EPA/AA ratio and changes of the serum lipid levels in patients with one or more risk factors for ASCVD...
July 16, 2018: Heart and Vessels
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