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https://www.readbyqxmd.com/read/29154107/aripiprazole-in-treatment-of-gilles-de-la-tourette-syndrome-new-therapeutic-option
#1
REVIEW
Piotr Janik, Natalia Szejko
Aripiprazole is a dopamine D2- and serotonin 5-hydroxytryptamine (5-HT)1A receptor partial agonist and 5-HT2A receptor antagonist primarily used for the treatment of schizophrenia, bipolar disorder or depression with psychotic ideation. However, recently a number of new possible indications have been suggested, among them Gilles de la Tourette syndrome (GTS). In two randomized, double-blind, placebo-controlled studies in children and adolescents with GTS has been confirmed the efficacy of aripiprazole in tic reduction...
November 9, 2017: Neurologia i Neurochirurgia Polska
https://www.readbyqxmd.com/read/29153958/major-and-minor-life-events-personality-and-psychopathology-in-children-with-tourette-syndrome
#2
Netta Horesh, Sharona Shmuel-Baruch, Dan Farbstein, Daphna Ruhrman, Noa Ben Aroya Milshtein, Silvana Fennig, Alan Apter, Tamar Steinberg
Environmental, psychological, and biological interactions underlie many psychopathologies. Tourette's Syndrome (TS) has an obvious biological substrate but environmental factors and personality play substantial roles in its expression. We aimed to study the interrelationships between stressful life events, personality traits, tics, and comorbid disorders in children with TS. To this end, 132 children with TS and 49 healthy controls were recruited for the study. Major life events in the 12-months prior to testing and minor life events in the month prior to testing were retrospectively assessed using the Life Experiences Survey (LES) and the Brief Adolescent Life Events Scale (BALES), respectively...
November 8, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/29151096/jumping-frenchmen-miryachit-and-latah-culture-specific-hyperstartle-plus-syndromes
#3
Douglas J Lanska
In the late 19th century, jumping (French Canadians in Maine, USA), miryachit (Siberia), and latah (Southeast Asia) were among a group of similar disorders described around the world, each of which manifests as an exaggerated startle response with additional late-response features that were felt by some to overlap with hysteria or tics. The later features following the exaggerated startle reaction variably include mimesis (e.g., echopraxia, echolalia) and automatic obedience. These reaction patterns tended to persist indefinitely in affected individuals...
2018: Frontiers of Neurology and Neuroscience
https://www.readbyqxmd.com/read/29149614/risky-business-the-circuits-that-impact-stress-induced-decision-making
#4
Amy F T Arnsten, Daeyeol Lee, Christopher Pittenger
How does stress promote risky decision-making? Friedman et al. find that stress disrupts inhibition of striatal circuits by prefrontal cortex, rendering animals insensitive to potential losses. This may help explain how stress contributes to substance abuse and how it can disinhibit automatic behaviors, such as tics in Tourette syndrome.
November 16, 2017: Cell
https://www.readbyqxmd.com/read/29133949/a-total-population-multigenerational-family-clustering-study-of-autoimmune-diseases-in-obsessive-compulsive-disorder-and-tourette-s-chronic-tic-disorders
#5
D Mataix-Cols, E Frans, A Pérez-Vigil, R Kuja-Halkola, C Gromark, K Isomura, L Fernández de la Cruz, E Serlachius, J F Leckman, J J Crowley, C Rück, C Almqvist, P Lichtenstein, H Larsson
The association between obsessive-compulsive disorder (OCD) and Tourette's/chronic tic disorders (TD/CTD) with autoimmune diseases (ADs) is uncertain. In this nationwide study, we sought to clarify the patterns of comorbidity and familial clustering of a broad range of ADs in individuals with OCD, individuals with TD/CTD and their biological relatives. From a birth cohort of 7 465 455 individuals born in Sweden between 1940 and 2007, we identified 30 082 OCD and 7279 TD/CTD cases in the National Patient Register and followed them up to 31 December 2013...
November 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/29132463/-serum-levels-of-25-hydroxyvitamin-d-in-children-with-tic-disorders
#6
Hong-Hua Li, Bing Wang, Ling Shan, Cheng-Xin Wang, Fei-Yong Jia
OBJECTIVE: To examine serum 25-hydroxyvitamin D levels in children with tic disorders (TD) and to explore the relationship between vitamin D level and TD. METHODS: One hundred and thirty-two children who were diagnosed with TD between November 2016 and May 2017 were enrolled as the TD group, including 8 cases of Tourette syndrome, 32 cases of chronic TD, and 92 cases of transient TD. One hundred and forty-four healthy children served as the control group. Peripheral venous blood samples were collected from each child...
November 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/29098466/prevalence-and-predictors-of-hair-pulling-disorder-and-excoriation-disorder-in-tourette-syndrome
#7
Erica Greenberg, Esther S Tung, Caitlin Gauvin, Lisa Osiecki, Kelly G Yang, Erin Curley, Angela Essa, Cornelia Illmann, Paul Sandor, Yves Dion, Gholson J Lyon, Robert A King, Sabrina Darrow, Matthew E Hirschtritt, Cathy L Budman, Marco Grados, David L Pauls, Nancy J Keuthen, Carol A Mathews, Jeremiah M Scharf
Trichotillomania/hair pulling disorder (HPD) and excoriation/skin picking disorder (SPD) are childhood-onset, body-focused repetitive behaviors that are thought to share genetic susceptibility and underlying pathophysiology with obsessive-compulsive disorder (OCD) and Tourette syndrome (TS). We sought to determine the prevalence of DSM-5 HPD and SPD in TS patients, and to identify clinical factors most associated with their co-morbidity with TS. Participants included 811 TS patients recruited from TS specialty clinics for a multi-center genetic study...
November 2, 2017: European Child & Adolescent Psychiatry
https://www.readbyqxmd.com/read/29060866/a-marked-point-process-approach-for-identifying-neural-correlates-of-tics-in-tourette-syndrome
#8
Carlos A Loza, Jonathan B Shute, Jose C Principe, Michael S Okun, Aysegul Gunduz
We propose a novel interpretation of local field potentials (LFP) based on a marked point process (MPP) framework that models relevant neuromodulations as shifted weighted versions of prototypical temporal patterns. Particularly, the MPP samples are categorized according to the well known oscillatory rhythms of the brain in an effort to elucidate spectrally specific behavioral correlates. The result is a transient model for LFP. We exploit data-driven techniques to fully estimate the model parameters with the added feature of exceptional temporal resolution of the resulting events...
July 2017: Conference Proceedings: Annual International Conference of the IEEE Engineering in Medicine and Biology Society
https://www.readbyqxmd.com/read/29057070/tourette-syndrome-research-highlights-from-2016
#9
REVIEW
Kevin J Black
This article presents highlights chosen from research that appeared during 2016 on Tourette syndrome and other tic disorders. Selected articles felt to represent meaningful advances in the field are briefly summarized.
2017: F1000Research
https://www.readbyqxmd.com/read/29053770/tourette-syndrome-a-disorder-of-the-social-decision-making-network
#10
Roger L Albin
Tourette syndrome is a common neurodevelopmental disorder defined by characteristic involuntary movements, tics, with both motor and phonic components. Tourette syndrome is usually conceptualized as a basal ganglia disorder, with an emphasis on striatal dysfunction. While considerable evidence is consistent with these concepts, imaging data suggest diffuse functional and structural abnormalities in Tourette syndrome brain. Tourette syndrome exhibits features that are difficult to explain solely based on basal ganglia circuit dysfunctions...
August 22, 2017: Brain: a Journal of Neurology
https://www.readbyqxmd.com/read/29053637/progress-in-genetic-studies-of-tourette-s-syndrome
#11
REVIEW
Yanjie Qi, Yi Zheng, Zhanjiang Li, Lan Xiong
Tourette's Syndrome (TS) is a complex disorder characterized by repetitive, sudden, and involuntary movements or vocalizations, called tics. Tics usually appear in childhood, and their severity varies over time. In addition to frequent tics, people with TS are at risk for associated problems including attention deficit hyperactivity disorder (ADHD), obsessive-compulsive disorder (OCD), anxiety, depression, and problems with sleep. TS occurs in most populations and ethnic groups worldwide, and it is more common in males than in females...
October 20, 2017: Brain Sciences
https://www.readbyqxmd.com/read/29046136/phenotype-development-in-adolescents-with-tourette-syndrome-a-large-clinical-longitudinal-study
#12
Camilla Groth, Nanette Mol Debes, Liselotte Skov
Tourette syndrome (TS) is a neurodevelopmental disorder characterized by frequent comorbidities and a wide spectrum of phenotype presentations. This study aimed to describe the development of phenotypes in TS and tic-related impairment in a large longitudinal study of 226 children and adolescents followed up after 6 years. The participants were clinically examined to assess tic severity and impairment, obsessive compulsive disorder (OCD), and attention-deficit/hyperactivity disorder (ADHD). The development in phenotypes changed toward less comorbidity with 40% TS-only (no OCD or ADHD) (TS without OCD or ADHD) at baseline and 55% at follow-up...
November 2017: Journal of Child Neurology
https://www.readbyqxmd.com/read/29017141/premonitory-urges-and-tics-in-tourette-syndrome-computational-mechanisms-and-neural-correlates
#13
REVIEW
Vasco A Conceição, Ângelo Dias, Ana C Farinha, Tiago V Maia
Tourette syndrome is characterized by open motor behaviors - tics - but another crucial aspect of the disorder is the presence of premonitory urges: uncomfortable sensations that typically precede tics and are temporarily alleviated by tics. We review the evidence implicating the somatosensory cortices and the insula in premonitory urges and the motor cortico-basal ganglia-thalamo-cortical loop in tics. We consider how these regions interact during tic execution, suggesting that the insula plays an important role as a nexus linking the sensory and emotional character of premonitory urges with their translation into tics...
October 2017: Current Opinion in Neurobiology
https://www.readbyqxmd.com/read/28966546/tic-treatment-goes-tech-a-review-of-tichelper-com
#14
Christine A Conelea, Brianna C M Wellen
TicHelper.com ("TicHelper") is an interactive online treatment program for youth with chronic tic disorders (CTDs) or Tourette Syndrome (TS) and their parents. It is based on Comprehensive Behavioral Intervention for Tics (CBIT), an individual, outpatient therapy protocol shown to effectively reduce tics in randomized controlled trials. The TicHelper website offers a user-friendly dashboard that is effective in making it easy to navigate through different treatment modules. Modules parallel core CBIT procedures and consist of interactive exercises, informational videos, and self-report ratings...
August 2017: Cognitive and Behavioral Practice
https://www.readbyqxmd.com/read/28965812/executive-control-development-in-tourette-syndrome-and-its-role-in-tic-reduction
#15
Asaf Yaniv, Noa Benaroya-Milshtein, Tamar Steinberg, Daphna Ruhrman, Alan Apter, Michal Lavidor
Tourette syndrome (TS) is a childhood-onset disorder characterized by motor and vocal tics. Recent findings point to a possible role of executive functions system development in the tic reduction observed with age. The goal of the present work was to track the development of executive functions system measured by well-established cognitive tasks and its correlation with diminished tic severity over time in order to understand the role of executive functions in the remission process observed in most adults. The first study followed 25 young TS patients, measuring their executive functions and clinical condition at three time- points...
September 18, 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28960154/report-of-a-patient-undergoing-chronic-responsive-deep-brain-stimulation-for-tourette-syndrome-proof-of-concept
#16
Rene Molina, Michael S Okun, Jonathan B Shute, Enrico Opri, P Justin Rossi, Daniel Martinez-Ramirez, Kelly D Foote, Aysegul Gunduz
Deep brain stimulation (DBS) has emerged as a promising intervention for the treatment of select movement and neuropsychiatric disorders. Current DBS therapies deliver electrical stimulation continuously and are not designed to adapt to a patient's symptoms. Continuous DBS can lead to rapid battery depletion, which necessitates frequent surgery for battery replacement. Next-generation neurostimulation devices can monitor neural signals from implanted DBS leads, where stimulation can be delivered responsively, moving the field of neuromodulation away from continuous paradigms...
September 29, 2017: Journal of Neurosurgery
https://www.readbyqxmd.com/read/28915150/tics-and-tourette-a-clinical-pathophysiological-and-etiological-review
#17
Russell C Dale
PURPOSE OF REVIEW: Describe developments in the etiological understanding of Tourette syndrome. RECENT FINDINGS: Tourette syndrome is a complex heterogenous clinical syndrome, which is not a unitary entity. Pathophysiological models describe gamma-aminobutyric acid-ergic-associated disinhibition of cortico-basal ganglia motor, sensory and limbic loops. MRI studies support basal ganglia volume loss, with additional white matter and cerebellar changes. Tourette syndrome cause likely involves multiple vulnerability genes and environmental factors...
December 2017: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/28894297/the-pnkd-gene-is-associated-with-tourette-disorder-or-tic-disorder-in-a-multiplex-family
#18
N Sun, C Nasello, L Deng, N Wang, Y Zhang, Z Xu, Z Song, K Kwan, R A King, Z P Pang, J Xing, G A Heiman, J A Tischfield
Tourette Disorder (TD) is a childhood-onset neuropsychiatric and neurodevelopmental disorder characterized by the presence of both motor and vocal tics. The genetic architecture of TD is believed to be complex and heterogeneous. Nevertheless, DNA sequence variants co-segregating with TD phenotypes within multiplex families have been identified. This report examines whole exomes of affected and unaffected individuals in a multiplex TD family to discover genes involved in the TD etiology. We performed whole exome sequencing on six out of nine members in a three-generation TD multiplex family...
September 12, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28878322/altered-topology-of-structural-brain-networks-in-patients-with-gilles-de-la-tourette-syndrome
#19
E Schlemm, B Cheng, F Fischer, C Hilgetag, C Gerloff, G Thomalla
Gilles de la Tourette syndrome is a neurodevelopmental disorder characterized by tics. Abnormal neuronal circuits in a wide-spread structural and functional network involved in planning, execution and control of motor functions are thought to represent the underlying pathology. We therefore studied changes of structural brain networks in 13 adult GTS patients reconstructed by diffusion tensor imaging and probabilistic tractography. Structural connectivity and network topology were characterized by graph theoretical measures and compared to 13 age-matched controls...
September 6, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28861008/case-of-secondary-tics-associated-with-olanzapine-in-an-adult
#20
Eric W Mills, Lindsay S Shaffer, Fernando S Goes, Akira Sawa, Frederick C Nucifora
Atypical antipsychotic medications, such as risperidone, aripiprazole, and olanzapine, have utility in treating motor tics, particularly in Tourette syndrome. In rare cases, atypical antipsychotic medications have been associated with adult-onset motor tics. Such adverse drug reactions have been documented in response to quetiapine, aripiprazole, and amisulpride. Here, we report, to our knowledge, the first case of adult-onset motor tics related to olanzapine administration.
2017: Frontiers in Psychiatry
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