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https://www.readbyqxmd.com/read/29758352/prospective-associations-of-c-reactive-protein-crp-levels-and-crp-genetic-risk-scores-with-risk-of-total-knee-and-hip-replacement-for-osteoarthritis-in-a-diverse-cohort
#1
Aladdin H Shadyab, Robert Terkeltaub, Charles Kooperberg, Alexander Reiner, Charles B Eaton, Rebecca D Jackson, Jessica L Krok-Schoen, Rany M Salem, Andrea Z LaCroix
OBJECTIVE: To examine associations of high-sensitivity C-reactive protein (CRP) levels and polygenic CRP genetic risk scores (GRS) with risk of end-stage hip or knee osteoarthritis (OA), defined as incident total hip (THR) or knee replacement (TKR) for OA. DESIGN: This study included a cohort of postmenopausal white, African American, and Hispanic women from the Women's Health Initiative. Women were followed from baseline to date of THR or TKR, death, or December 31, 2014...
May 11, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29757058/outcomes-following-hip-and-knee-replacement-in-diabetic-versus-nondiabetic-patients-and-well-versus-poorly-controlled-diabetic-patients-a-prospective-cohort-study
#2
Erik Lenguerrand, Andrew D Beswick, Michael R Whitehouse, Vikki Wylde, Ashley W Blom
Background and purpose - The impact of diabetes and glycemic control before joint replacement on clinical and patient-reported outcomes is unclear. We compared pain, function, complications, and length of hospital stay in diabetic and nondiabetic patients receiving primary total hip (THR) or knee replacement (TKR) and compared these outcomes in patients with poorly controlled versus well-controlled diabetes. Patients and methods - We conducted a prospective cohort study of patients undergoing primary THR (n = 300) or TKR (n = 287) for osteoarthritis...
May 14, 2018: Acta Orthopaedica
https://www.readbyqxmd.com/read/29752509/current-concepts-and-future-perspectives-in-computer-assisted-navigated-total-knee-replacement
#3
REVIEW
Tomoyuki Matsumoto, Naoki Nakano, John E Lawrence, Vikas Khanduja
BACKGROUND: Total knee replacements (TKR) aim to restore stability of the tibiofemoral and patella-femoral joints and provide relief of pain and improved quality of life for the patient. In recent years, computer-assisted navigation systems have been developed with the aim of reducing human error in joint alignment and improving patient outcomes. METHODS: We examined the current body of evidence surrounding the use of navigation systems and discussed their current and future role in TKR...
May 12, 2018: International Orthopaedics
https://www.readbyqxmd.com/read/29746853/characterization-of-a-tachykinin-signalling-system-in-the-bivalve-mollusc-crassostrea-gigas
#4
Marie-Pierre Dubos, Sven Zels, Julie Schwartz, Jeremy Pasquier, Liliane Schoofs, Pascal Favrel
Although tachykinin-like neuropeptides have been identified in molluscs more than two decades ago, knowledge on their function and signalling has so far remained largely elusive. We developed a cell-based assay to address the functionality of the tachykinin G-protein coupled receptor (Cragi-TKR) in the oyster Crassostrea gigas. The oyster tachykinin neuropeptides that are derived from the tachykinin precursor gene Cragi-TK activate the Cragi-TKR in nanomolar concentrations. Receptor activation is sensitive to Ala-substitution of critical Cragi-TK amino acid residues...
May 7, 2018: General and Comparative Endocrinology
https://www.readbyqxmd.com/read/29743853/mitochondrial-dna-copy-number-instability-in-erbb2-amplified-breast-cancer-tumors
#5
Elmira Ebrahimi, Amir Almasi-Hashiani, Kimia Ghaffari, Reza Shirkoohi
Increase in the copy number of ERBB2 , a Tyrosine Kinase Receptor (TKR) leads to the overexpression of oncogene product and consequently uncontrolled cell proliferation which has been reported in different aggressive cancers with mitochondrial malfunctions. Although, amplification of ERBB2 has been reported in different studies; however, the association between changes in mitochondrial DNA content and the ERBB2 gene copy number is poorly understood. The relative mitochondrial DNA content of breast cancer tumor tissues of 70 patients who were referred to Imam Khomeini Hospital Complex was determined using quantitative Real-time PCR...
2018: EXCLI Journal
https://www.readbyqxmd.com/read/29743064/patient-directed-self-management-of-pain-padsmap-compared-to-treatment-as-usual-following-total-knee-replacement-a-randomised-controlled-trial
#6
Katherine H O Deane, Richard Gray, Paula Balls, Clare Darrah, Louise Swift, Alan B Clark, Garry R Barton, Sophie Morris, Sue Butters, Angela Bullough, Helen Flaherty, Barbara Talbot, Mark Sanders, Simon T Donell
BACKGROUND: Self-administration of medicines by patients whilst in hospital is being increasingly promoted despite little evidence to show the risks and benefits. Pain control after total knee replacement (TKR) is known to be poor. The aim of the study was to determine if patients operated on with a TKR who self-medicate their oral analgesics in the immediate post-operative period have better pain control than those who receive their pain control by nurse-led drug rounds (Treatment as Usual (TAU))...
May 10, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29723634/total-knee-replacement-and-non-surgical-treatment-of-knee-osteoarthritis-2-year-outcome-from-two-parallel-randomized-controlled-trials
#7
Søren T Skou, Ewa M Roos, Mogens B Laursen, Michael S Rathleff, Lars Arendt-Nielsen, Sten Rasmussen, Ole Simonsen
OBJECTIVES: To compare 2-year outcomes of total knee replacement (TKR) followed by non-surgical treatment to that of non-surgical treatment alone and outcomes of the same non-surgical treatment to that of written advice. DESIGN: In two randomized trials, 200 (mean age 66) adults with moderate to severe knee osteoarthritis (OA), 100 eligible for TKR and 100 not eligible for TKR, were randomized to TKR followed by non-surgical treatment, non-surgical treatment alone, or written advice...
April 30, 2018: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/29721453/tibiofemoral-wear-in-standard-and-non-standard-squat-implication-for-total-knee-arthroplasty
#8
REVIEW
Gusztáv Fekete, Dong Sun, Yaodong Gu, Patric Daniel Neis, Ney Francisco Ferreira, Bernardo Innocenti, Béla M Csizmadia
Introduction: Due to the more resilient biomaterials, problems related to wear in total knee replacements (TKRs) have decreased but not disappeared. In the design-related factors, wear is still the second most important mechanical factor that limits the lifetime of TKRs and it is also highly influenced by the local kinematics of the knee. During wear experiments, constant load and slide-roll ratio is frequently applied in tribo-tests beside other important parameters. Nevertheless, numerous studies demonstrated that constant slide-roll ratio is not accurate approach if TKR wear is modelled, while instead of a constant load, a flexion-angle dependent tibiofemoral force should be involved into the wear model to obtain realistic results...
October 2017: Muscles, Ligaments and Tendons Journal
https://www.readbyqxmd.com/read/29715715/treatment-of-recurrent-hemarthrosis-after-total-knee-arthroplasty
#9
Ju-Hyung Yoo, Hyun-Cheol Oh, Sang-Hoon Park, Sanghyeon Lee, Yunjae Lee, Seong-Hun Kim
Purpose: The purpose of this study is to evaluate the incidence and treatment of recurrent hemarthrosis after total knee replacement (TKR). Materials and Methods: Among a total of 5,510 patients who underwent TKR from March 2000 to October 2016, patients who had two or more bleeding 2 weeks after surgery were studied. Conservative treatments were performed for all cases with symptoms. In patients who did not respond to conservative treatment several times, embolization was performed...
April 30, 2018: Knee Surgery & related Research
https://www.readbyqxmd.com/read/29706598/cost-effectiveness-of-unicompartmental-compared-with-total-knee-replacement-a-population-based-study-using-data-from-the-national-joint-registry-for-england-and-wales
#10
Edward Burn, Alexander D Liddle, Thomas W Hamilton, Andrew Judge, Hemant G Pandit, David W Murray, Rafael Pinedo-Villanueva
OBJECTIVES: To assess the value for money of unicompartmental knee replacement (UKR) compared with total knee replacement (TKR). DESIGN: A lifetime Markov model provided the framework for the analysis. SETTING: Data from the National Joint Registry (NJR) for England and Wales primarily informed the analysis. PARTICIPANTS: Propensity score matched patients in the NJR who received either a UKR or TKR. INTERVENTIONS: UKR is a less invasive alternative to TKR, where only the compartment affected by osteoarthritis is replaced...
April 29, 2018: BMJ Open
https://www.readbyqxmd.com/read/29700210/genomic-profiling-of-her2-positive-gastric-cancer-pi3k-akt-mtor-pathway-as-predictor-of-outcomes-in-her2-positive-advanced-gastric-cancer-treated-with-trastuzumab
#11
Asunción Díaz-Serrano, Barbara Angulo, Carolina Dominguez, Roberto Pazo-Cid, Antonieta Salud, Paula Jiménez-Fonseca, Ana Leon, Maria Carmen Galan, Maria Alsina, Fernando Rivera, J Carlos Plaza, Luis Paz-Ares, Fernando Lopez-Rios, Carlos Gómez-Martín
BACKGROUND: HER2-positive gastric cancer (GC) affects 7%-34% of patients with GC. Trastuzumab-based first-line treatment has become the standard of care for HER2-positive advanced gastric cancer (AGC). However, there are no clinically validated biomarkers for resistance to HER2-targeted therapies. Upregulation of PI3K pathway and tyrosine kinase receptor (TKR) alterations have been noted as molecular mechanisms of resistance in breast cancer. Our study aimed to perform a molecular characterization of HER2-positive AGC and investigate the role of PI3K/Akt/mTOR signaling pathway activation and TKR gene copy number (GCN) gains as predictive biomarkers in HER2-positive AGC treated with trastuzumab...
April 26, 2018: Oncologist
https://www.readbyqxmd.com/read/29666082/knee-joint-instability-after-total-knee-replacement-in-a-patient-with-ehlers-danlos-syndrome-the-role-of-insert-changes-as-practical-solution
#12
Ajmal Farid, Stefan Beekhuizen, Joris van der Lugt, Marijn Rutgers
Treatment of knee joint instability in patients with hypermobile Ehlers-Danlos syndrome (EDS) can be challenging. A 53-year-old woman with hypermobile EDS underwent bilateral total knee replacement (TKR) due to valgus osteoarthritis. During follow-up, she developed hypermobility of both knee replacements. Revision of the insert resolved the issue in her left knee; however, the right TKR required two insert exchanges and unfortunately instability persisted. Therefore, a revision to a constrained prosthesis was performed...
April 17, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29656439/investigating-the-motives-of-patients-with-knee-oa-undergoing-a-tkr-a-qualitative-interview-study
#13
Line Traumer, Erik Elgaard Sørensen, Kathrine Hoffmann Kusk, Søren Thorgaard Skou
No abstract text is available yet for this article.
April 15, 2018: Musculoskeletal Care
https://www.readbyqxmd.com/read/29643169/safety-and-feasibility-evaluation-of-tourniquets-for-total-knee-replacement-safe-tkr-study-protocol
#14
Peter Dh Wall, Imran Ahmed, Andrew Metcalfe, Andrew J Price, Kate Seers, Charles E Hutchinson, Helen Parsons, Jane Warwick, Bushra Rahman, Jaclyn Brown, Martin Underwood
INTRODUCTION: This study is designed to determine whether a full randomised controlled trial (RCT) examining the clinical effectiveness and safety of total knee replacement surgery with or without a tourniquet is warranted and feasible. METHOD AND ANALYSIS: Single centre, patient-blinded and assessor-blinded RCT. A computer-generated randomisation service will allocate 50 participants into one of two trial treatments, surgery with or without a tourniquet. The primary objective is to estimate recruitment, crossovers and follow-up of patients...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29643154/associations-between-preoperative-oxford-hip-and-knee-scores-and-costs-and-quality-of-life-of-patients-undergoing-primary-total-joint-replacement-in-the-nhs-england-an-observational-study
#15
Peter Eibich, Helen A Dakin, Andrew James Price, David Beard, Nigel K Arden, Alastair M Gray
OBJECTIVES: To assess how costs and quality of life (measured by EuroQoL-5 Dimensions (EQ-5D)) before and after total hip replacement (THR) and total knee replacement (TKR) vary with age, gender and preoperative Oxford hip score (OHS) and Oxford knee score (OKS). DESIGN: Regression analyses using prospectively collected data from clinical trials, cohort studies and administrative data bases. SETTING: UK secondary care. PARTICIPANTS: Men and women undergoing primary THR or TKR...
April 10, 2018: BMJ Open
https://www.readbyqxmd.com/read/29628679/patellofemoral-arthroplasty-current-concepts
#16
REVIEW
Rory Cuthbert, Saket Tibrewal, Sheo B Tibrewal
Isolated patellofemoral arthritis (IPA) is a debilitating condition characterised by a loss of articular cartilage on the patella facets, the trochlear groove or both. By definition, patients with IPA must have normal cartilage in the tibiofemoral compartments of their knee. It is therefore logical to pursue arthroplasty which corrects the abnormality while sparing healthy bone and preserving the knee's native kinematics, which is the premise underpinning patellofemoral arthroplasty (PFA). However, its use remains controversial, with many surgeons still favouring total knee replacement (TKR) in these patients...
January 2018: Journal of Clinical Orthopaedics and Trauma
https://www.readbyqxmd.com/read/29627736/regression-models-to-predict-the-behavior-of-the-coefficient-of-friction-of-aisi-316l-on-uhmwpe-under-iso-14243-3-conditions
#17
A L Garcia-Garcia, M Alvarez-Vera, L A Montoya-Santiyanes, I Dominguez-Lopez, J L Montes-Seguedo, J C Sosa-Savedra, J D O Barceinas-Sanchez
Friction is the natural response of all tribosystems. In a total knee replacement (TKR) prosthetic device, its measurement is hindered by the complex geometry of its integrating parts and that of the testing simulation rig operating under the ISO 14243-3:2014 standard. To develop prediction models of the coefficient of friction (COF) between AISI 316L steel and ultra-high molecular weight polyethylene (UHMWPE) lubricated with fetal bovine serum dilutions, the arthrokinematics and loading conditions prescribed by the ISO 142433: 2014 standard were translated to a simpler geometrical setup, via Hertz contact theory...
March 27, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29622481/pre-clinical-assessment-of-total-knee-replacement-anterior-posterior-constraint
#18
C Halewood, K K Athwal, A A Amis
Pre-clinical, bench-top assessment of Total Knee Replacements (TKR) can provide information about the inherent constraint provided by a TKR, which does not depend on the condition of the patient undergoing the arthroplasty. However little guidance is given by the ASTM standard on test configurations such as medial-lateral (M:L) loading distribution, flexion angle or restriction of secondary motions. Using a purpose built rig for a materials testing machine, four TKRs currently in widespread clinical use, including medial-pivot and symmetrical condyle types, were tested for anterior-posterior translational constraint...
March 30, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29608733/a-physical-therapist-administered-physical-activity-intervention-after-total-knee-replacement-protocol-for-a-randomized-controlled-trial
#19
Meredith B Christiansen, Louise M Thoma, Hiral Master, Laura A Schmitt, Ryan Pohlig, Daniel K White
Background: The definitive treatment for knee osteoarthritis is a total knee replacement, which results in a clinically meaningful improvement in pain and physical function. However, evidence suggests that physical activity (PA) remains unchanged after total knee replacement (TKR). Objective: The objective of this study is to investigate the efficacy, fidelity, and safety of a physical therapist-administered PA intervention for people after TKR. Design: This study is a protocol for a randomized controlled trial...
March 28, 2018: Physical Therapy
https://www.readbyqxmd.com/read/29603823/effects-of-nurse-led-lower-extremity-strength-training-on-knee-function-recovery-in-patients-who-underwent-total-knee-replacement
#20
Yu-Hua Lin, Su-Ying Lee, Wei-Ren Su, Chia-Chan Kao, Ta-Wei Tai, Tai-Been Chen
AIM: The purpose of this study was to examine the effects of lower extremity muscle strength training (LEMST) on knee function recovery and QoL in patients who underwent total knee replacement (TKR). BACKGROUND: Patients with knee osteoarthritis (OA) after surgery experience decreased knee function that impacts their quality of life (QoL). However, patients typically lack a long-term, home-based, and continuous leg exercise training method, and rarely have studies explored the effects of exercise training on knee function recovery and QoL...
March 31, 2018: Journal of Clinical Nursing
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