keyword
MENU ▼
Read by QxMD icon Read
search

TKR

keyword
https://www.readbyqxmd.com/read/28922684/-rbc-transfusion-triggers-in-orthopaedic-lower-limb-arthroplasty
#1
Dirk Holten, Peter Zaar, Stefan Kessler
Introduction We implemented a hospital-wide mandatory RBC transfusion trigger checklist based on the haemoglobin level transfusion thresholds recommended by the German federal physicians board. Transfusion triggers, transfusion rates and hospital LOS in orthopaedic lower limb arthroplasty were compared before and after implementation of the transfusion trigger checklist. The goal was to evaluate the effect of this single and easy-to-implement intervention on transfusion rates in orthopaedic lower limb arthroplasty...
September 18, 2017: Zeitschrift Für Orthopädie und Unfallchirurgie
https://www.readbyqxmd.com/read/28917522/does-physical-activity-change-following-hip-and-knee-replacement-matched-case-control-study-evaluating-physical-activity-scale-for-the-elderly-data-from-the-osteoarthritis-initiative
#2
T O Smith, M Mansfield, J Dainty, G Hilton, C J V Mann, C M Sackley
OBJECTIVES: To determine whether physical activity measured using the Physical Activity Scale for the Elderly (PASE), changes during the initial 24 months post-total hip (THR) or knee replacement (TKR), and how this compares to a matched non-arthroplasty cohort. DESIGN: Case-controlled study analysis of a prospectively collected dataset. SETTING: USA community-based. PARTICIPANTS: 116 people post-THR, 105 people post-TKR compared to 663 people who had not undergone THR or TKR, or had hip or knee osteoarthritis...
September 13, 2017: Physiotherapy
https://www.readbyqxmd.com/read/28915156/a-risk-calculator-using-preoperative-opioids-for-prediction-of-total-knee-revision-arthroplasty
#3
Jordan Starr, Irene Rozet, Alon Ben-Ari
OBJECTIVES: Total knee arthroplasty (TKA) is a procedure to improve quality of life. However, some patients require early total knee revision (TKR). Chronic opioid use before TKA is associated with TKR. No risk calculator including opioid use or other risk factors is currently available for predicting TKR. MATERIALS AND METHODS: We retrospectively analyzed medical records of Veterans Affairs patients who underwent TKA from January 1, 2006 to January 1, 2012. Patients were followed until January 1, 2013...
September 14, 2017: Clinical Journal of Pain
https://www.readbyqxmd.com/read/28914139/the-influence-of-geometric-design-variables-on-the-kinematic-performance-of-a-surface-guided-total-knee-replacement
#4
Shabnam Pejhan, Eric Bohm, Jan-Mels Brandt, Urs Wyss
OBJECTIVE: Tibiofemoral geometries in a total knee replacement (TKR) affect the performance of an implant during activities of daily living. The specially shaped components of a surface-guided TKR aim to control the tibiofemoral motion, such that a normal pattern of motion is achieved, even at high flexion angles. The purpose of this study was to assess the influence of the design parameters on the kinematic behavior of such an implant. A combination of design variables was determined that resulted in the least deviation from the design kinematic target...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28901843/coevolution-of-the-translational-machinery-optimizes-initiation-with-unusual-initiator-trnas-and-initiation-codons-in-mycoplasmas
#5
Shreya Ahana Ayyub, Divya Dobriyal, Riyaz Ahmad Shah, Kuldeep Lahry, Madhumita Bhattacharyya, Souvik Bhattacharyya, Saikat Chakrabarti, Umesh Varshney
Initiator tRNAs (i-tRNAs) are characterized by the presence of three consecutive GC base pairs (GC/GC/GC) in their anticodon stems in all domains of life. However, many mycoplasmas possess unconventional i-tRNAs wherein the highly conserved sequence of GC/GC/GC is represented by AU/GC/GC, GC/GC/GU or AU/GC/GU. These mycoplasmas also tend to preferentially utilize non-AUG initiation codons. To investigate if initiation with the unconventional i-tRNAs and non-AUG codons in mycoplasmas correlated with the changes in the other components of the translation machinery, we carried out multiple sequence alignments of genes encoding initiation factors (IF), 16S rRNAs, and the ribosomal proteins such as uS9, uS12 and uS13...
September 13, 2017: RNA Biology
https://www.readbyqxmd.com/read/28868567/gait-analysis-of-patients-with-an-off-the-shelf-total-knee-replacement-versus-customized-bi-compartmental-knee-replacement
#6
Henry Wang, Jonathan Foster, Natasha Franksen, Jill Estes, Lindsey Rolston
INTRODUCTION: Newer TKR designs have been introduced to the market with the aim of overcoming common sizing problems with older TKR designs. Furthermore, since a sizable percentage of patients with OA present with disease limited to the medial/lateral knee compartment in addition to the patellofemoral joint, for whom, a customized bi-compartmental knee replacement (BKR) is available as a treatment option. To date, there is very little information regarding knee strength and mechanics during gait for patients implanted with these modern TKR and BKR designs...
September 4, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28821515/does-the-person-s-context-influence-engagement-in-life-activities-following-primary-knee-replacement-results-from-a-canadian-prospective-cohort-study
#7
Aileen M Davis, Viji Venkataramanan, Jessica Bytautas-Sillanpää, Anthony V Perruccio, Rosalind Wong, Lisa Carlesso, Fiona Webster
OBJECTIVE: The impact of the context of a person's life on recovery from surgical interventions is not well understood. This study evaluated if people's social, environmental and biomedical context was associated with change in frequency in engagement in life activities after total knee replacement (TKR). METHODS: 418 people aged 30+ years who had TKR were followed presurgery to 1 year postsurgery. The outcome was change in frequency in engagement in life activities measured by the Late Life Disability Index (LLDI)...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28807525/experimental-and-computational-analysis-of-micromotions-of-an-uncemented-femoral-knee-implant-using-elastic-and-plastic-bone-material-models
#8
Sanaz Berahmani, Dennis Janssen, Nico Verdonschot
It is essential to calculate micromotions at the bone-implant interface of an uncemented femoral total knee replacement (TKR) using a reliable computational model. In the current study, experimental measurements of micromotions were compared with predicted micromotions by Finite Element Analysis (FEA) using two bone material models: linear elastic and post-yield material behavior, while an actual range of interference fit was simulated. The primary aim was to investigate whether a plasticity model is essential in order to calculate realistic micromotions...
July 29, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28771428/a-novel-ceramic-tibial-component-is-as-safe-as-its-metal-counterpart
#9
Klemens Trieb
Failure rates of 2-10% provide evidence for further development in knee arthroplasty. The purpose of our study was to examine the safety of the tibial component of a novel all-ceramic total knee replacement (TKR) (BPK-S Integration ceramic) consisting of BIOLOX®delta ceramic. The standards ISO 14879-1 and ASTM F1800-07 describe the test set-up for the experimental strength verification with a significantly increased maximum load of 5300 N (900 N are required) and post-fatigue burst strength testing. All specimens were able to prove their mechanical strength against fracture in the alternating load test...
August 3, 2017: Biomedizinische Technik. Biomedical Engineering
https://www.readbyqxmd.com/read/28764690/delayed-anti-tnf-therapy-increases-the-risk-of-total-knee-replacement-in-patients-with-severe-rheumatoid-arthritis
#10
Ying-Chou Chen, Wen-Chan Chiu, Tien-Tsai Cheng, Han-Ming Lai, Shan-Fu Yu, Ben Yu-Jih Su, Chung-Yuan Hsu, Chi-Hua Ko, Jia-Feng Chen
BACKGROUND: This study evaluated the effect of early anti-tumor necrosis factor (TNF) therapy in patients with severe rheumatoid arthritis (RA) on the subsequent risk of total knee replacement (TKR) surgery. METHODS: This retrospective observational study included a hospital-based cohort of 200 patients diagnosed with severe RA who received treatment with anti-TNF therapy between 2003 and 2014. Clinical parameters including age, sex, body mass index, and the time from the diagnosis of RA to the initiation of anti-TNF therapy were analyzed...
August 1, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28764280/content-validation-of-total-knee-replacement-rehabilitation-protocol-in-indian-population
#11
P Antony Leo Aseer, G Arun Maiya, M Mohan Kumar, P V Vijayaraghavan
INTRODUCTION: Total knee replacement (TKR) surgery has become the most successful surgery for patients with severe debilitating arthritis. The guidelines for rehabilitation progression should be tailored respecting the tissue healing parameters. Hence, the current literature states a need for protocol to mitigate these impairments and ultimately result in improved functional outcomes. OBJECTIVE: The present study aimed to validate the content of TKR rehabilitation protocol in Indian population...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28760574/physical-function-after-total-knee-replacement-an-observational-study-describing-outcomes-in-a-small-group-of-women-from-china-and-the-united-states
#12
Daniel K White, Zhichang Li, Yuqing Zhang, Adam R Marmon, Hiral Master, Joseph Zeni, Jingbo Niu, Long Jiang, Shu Zhang, Jianhao Lin
OBJECTIVE: To describe physical function before and six months after Total Knee Replacement (TKR) in a small sample of women from China and the United States (US). PARTICIPANTS: 60 women after TKR from China and the US Design, Setting, Outcomes: Data was from an observational study of TKR outcomes in Newark, Delaware (US group) and a control group after TKR in Beijing (China group). Both groups followed the same Osteoarthritis Research Society International (OARSI) protocols for the six-minute walk and 30-second chair stand...
July 28, 2017: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/28757187/gout-and-risk-of-knee-replacement-for-severe-knee-osteoarthritis-in-the-singapore-chinese-health-study
#13
G G Teng, Y Y Leung, L-W Ang, J-M Yuan, W-P Koh
OBJECTIVE: While cross-sectional and retrospective case-control studies suggest that gout is associated with knee osteoarthritis (KOA), no prospective study has evaluated the risk of total knee replacement (TKR) for KOA in association with gout. We prospectively evaluated the association between gout and the risk of TKR due to severe KOA. DESIGN: We used data from the Singapore Chinese Health Study (SCHS), a prospective cohort with 63,257 Chinese adults aged 45-74 years at recruitment (1993-1998)...
July 27, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28732147/financial-incentives-and-health-coaching-to-improve-physical-activity-following-total-knee-replacement-a-randomized-controlled-trial
#14
Elena Losina, Jamie E Collins, Bhushan R Deshpande, Savannah R Smith, Griffin L Michl, Ilana M Usiskin, Kristina M Klara, Amelia R Winter, Heidi Y Yang, Faith Selzer, Jeffrey N Katz
OBJECTIVE: Most persons who undergo total knee replacement (TKR) do not increase their physical activity following surgery. We assessed whether financial incentives and health coaching would improve physical activity in persons undergoing TKR. METHODS: We designed a factorial randomized controlled trial among persons undergoing TKR for osteoarthritis. Subjects underwent normal perioperative procedures, including post-operative physical therapy, and were assigned to one of four arms: attention control, telephonic health coaching (THC), financial incentives (FI), or THC+FI...
July 21, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28719611/rna-sequencing-to-determine-the-contribution-of-kinase-receptor-transactivation-to-g-protein-coupled-receptor-signalling-in-vascular-smooth-muscle-cells
#15
Danielle Kamato, Venkata Vijayanand Bhaskarala, Nitin Mantri, Tae Gyu Oh, Dora Ling, Reearna Janke, Wenhua Zheng, Peter J Little, Narin Osman
G protein coupled receptor (GPCR) signalling covers three major mechanisms. GPCR agonist engagement allows for the G proteins to bind to the receptor leading to a classical downstream signalling cascade. The second mechanism is via the utilization of the β-arrestin signalling molecule and thirdly via transactivation dependent signalling. GPCRs can transactivate protein tyrosine kinase receptors (PTKR) to activate respective downstream signalling intermediates. In the past decade GPCR transactivation dependent signalling was expanded to show transactivation of serine/threonine kinase receptors (S/TKR)...
2017: PloS One
https://www.readbyqxmd.com/read/28719557/functional-gain-and-pain-relief-after-total-joint-replacement-according-to-obesity-status
#16
MULTICENTER STUDY
Wenjun Li, David C Ayers, Courtland G Lewis, Thomas R Bowen, Jeroan J Allison, Patricia D Franklin
BACKGROUND: Obesity has been associated with lower function and more pain before and after total hip or knee replacement (THR or TKR). We examined the changes between preoperative and postoperative function and pain in a large representative U.S. cohort to determine if there was a relationship to obesity status. METHODS: Preoperative and 6-month postoperative data on function (Short Form-36 Physical Component Summary [PCS] score), joint pain (Hip disability and Osteoarthritis Outcome Score and Knee injury and Osteoarthritis Outcome Score), and body mass index (BMI) were collected from a national sample of 2,040 patients who had undergone THR and 2,964 who had undergone TKR from May 2011 to March 2013...
July 19, 2017: Journal of Bone and Joint Surgery. American Volume
https://www.readbyqxmd.com/read/28705915/microarray-analysis-of-bone-marrow-lesions-in-osteoarthritis-demonstrates-upregulation-of-genes-implicated-in-osteochondral-turnover-neurogenesis-and-inflammation
#17
Anasuya Kuttapitiya, Lena Assi, Ken Laing, Caroline Hing, Philip Mitchell, Guy Whitley, Abiola Harrison, Franklyn A Howe, Vivian Ejindu, Christine Heron, Nidhi Sofat
OBJECTIVE: Bone marrow lesions (BMLs) are well described in osteoarthritis (OA) using MRI and are associated with pain, but little is known about their pathological characteristics and gene expression. We evaluated BMLs using novel tissue analysis tools to gain a deeper understanding of their cellular and molecular expression. METHODS: We recruited 98 participants, 72 with advanced OA requiring total knee replacement (TKR), 12 with mild OA and 14 non-OA controls...
July 13, 2017: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/28705605/age-of-menarche-is-associated-with-knee-joint-replacement-due-to%C3%A2-primary-osteoarthritis-the-hunt-study-and-the-norwegian-arthroplasty-register
#18
A I Hellevik, L Nordsletten, M B Johnsen, A M Fenstad, O Furnes, K Storheim, J A Zwart, G Flugsrud, A Langhammer
OBJECTIVE: To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis. METHOD: In a prospective cohort study of 30,289 women from the second and third surveys of the Nord-Trøndelag Health Study, data were linked to the Norwegian Arthroplasty Register (NAR) in order to identify TKR or THR due to primary osteoarthritis...
July 10, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28690046/kinematic-behavior-of-a-customized-surface-guided-knee-implant-during-simulated-knee-bending
#19
Shabnam Pejhan, Eric Bohm, Jan-Mels Brandt, Trevor Gascoyne, Urs Wyss
Different designs of total knee replacements (TKRs) aim to enhance the satisfaction of the patients by providing close to normal kinematics. In the surface-guided TKRs, the guidance of the motion in a normal pattern should be achieved through specially shaped articulating geometries. This study used virtual simulation along with a load-controlled knee wear simulator to evaluate the kinematic performance of a customized surface-guided TKR under weight-bearing conditions of lunging and squatting activities. The outcome pattern of TKR motion almost agreed with the predefined design target...
July 6, 2017: Medical Engineering & Physics
https://www.readbyqxmd.com/read/28678604/a-post-marketing-assessment-of-major-bleeding-in-total-hip-and-total-knee-replacement-surgery-patients-receiving-rivaroxaban
#20
Louis M Kwong, Alexander G G Turpie, Sally Tamayo, W Frank Peacock, Zhong Yuan, Nicholas Sicignano, Kathleen Pillsbury Hopf, Manesh R Patel
BACKGROUND: Rivaroxaban is a novel oral anticoagulant indicated for prophylaxis against deep vein thrombosis and pulmonary embolism in patients undergoing total hip replacement (THR) or total knee replacement (TKR) surgery. OBJECTIVE: To evaluate major bleeding (MB) in THR/TKR patients receiving post-operative rivaroxaban. METHODS: Electronic medical records of nearly 10 million US Department of Defense (DoD) beneficiaries were queried from 1 January 2013 through 30 June 2015...
July 20, 2017: Current Medical Research and Opinion
keyword
keyword
82095
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"