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https://www.readbyqxmd.com/read/28217891/a-comprehensive-behavioral-and-exercise-intervention-improves-physical-function-and-activity-participation-after-total-knee-replacement-a-pilot-randomized-study
#1
Sara R Piva, Gustavo J Almeida, Alexandra B Gil, Anthony M DiGioia, Diane L Helsel, Gwendolyn A Sowa
OBJECTIVE: To test the feasibility of a comprehensive behavioral intervention (CBI) program that combines intense exercises with an education program to be implemented at a later stage (3 months) post total knee replacement (TKR), and to get a first impression of the effects of the CBI as compared to a standard of care exercise (SCE) program on the outcomes of physical function and physical activity. METHODS: 44 subjects participated in a 3-month program of either CBI or SCE followed by 3 months of home exercise program...
February 19, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28216311/meniscal-extrusion-and-bone-marrow-lesions-are-associated-with-incident-and-progressive-knee-osteoarthritis
#2
Andrew J Teichtahl, Flavia M Cicuttini, François Abram, Yuanyuan Wang, Jean-Pierre Pelletier, Pierre Dodin, Johanne Martel-Pelletier
OBJECTIVE: Whether meniscal extrusion and bone marrow lesions (BMLs) are independently associated with the risk of knee osteoarthritis (OA) is unknown. METHODS: Data was extracted from the Osteoarthritis Initiative (OAI) cohort. Participants were grouped according to the absence (Kellgren-Lawrence (KL) grade ≤ 1, n = 2120) or presence (KL ≥ 2, n = 2249) of ROA. Baseline meniscal extrusion and tibial BMLs were assessed. Tibial plateau cartilage volume was assessed at baseline and 72 months, while radiographic disease was assessed at baseline and 48 months...
February 12, 2017: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/28210821/p-f-c-sigma-%C3%A2-cruciate-retaining-fixed-bearing-versus-mobile-bearing-knee-arthroplasty-a-prospective-comparative-study-with-minimum-10-year-follow-up
#3
O Riaz, A Aqil, G Sisodia, G Chakrabarty
AIMS: To prospectively compare long-term clinical and radiological outcomes following a cruciate retaining fixed-bearing (FB) and a mobile-bearing (MB) primary total knee replacement (TKR). METHODS: We prospectively reviewed 113 TKRs in 99 patients (14 bilateral) with a PFC sigma cruciate retaining rotating platform system, at an average follow-up of 11.1 years (range 10-12). Results were contrasted with those from 89 TKRs in 72 patients (17 bilateral) with a PFC sigma cruciate fixed-bearing prosthesis, at an average follow-up of 12...
February 16, 2017: European Journal of Orthopaedic Surgery & Traumatology: Orthopédie Traumatologie
https://www.readbyqxmd.com/read/28185212/economic-evaluations-of-new-oral-anticoagulants-for-the-prevention-of-venous-thromboembolism-after-total-hip-or-knee-replacement-a-systematic-review
#4
REVIEW
James Brockbank, Sorrel Wolowacz
BACKGROUND: Total hip replacement (THR) and total knee replacement (TKR) surgeries are being performed with increasing regularity and are associated with a high risk of developing a venous thromboembolism (VTE). New oral anticoagulants (NOACs) may be more effective at preventing VTEs but are associated with more bleeding events versus traditional anticoagulants. OBJECTIVE: The objective of this systematic review was to identify published economic analyses of NOACs for primary VTE prophylaxis following THR and TKR surgeries, and to summarise the modelling techniques used and the cost-effectiveness results...
February 10, 2017: PharmacoEconomics
https://www.readbyqxmd.com/read/28178956/translation-and-validation-of-the-12-item-oxford-knee-score-for-use-in-finland
#5
Aleksi Reito, Anni Järvistö, Esa Jämsen, Eerik Skyttä, Ville Remes, Heini Huhtala, Mika Niemeläinen, Antti Eskelinen
BACKGROUND: The focus in the reporting of results after total knee replacement (TKR) has changed from surgeon/radiologist-based scores to patient-reported outcome measures (PROMs). The questionnaires used in subjective outcome are often originally published in English and need to be validated in different languages. The aim of our study was to investigate the feasibility, validity, reliability, and responsiveness of the Finnish language version of the Oxford Knee Score (OKS-S) questionnaire...
February 8, 2017: BMC Musculoskeletal Disorders
https://www.readbyqxmd.com/read/28174415/comparison-of-enoxaparin-and-rivaroxaban-in-balance-of-anti-fibrinolysis-and-anticoagulation-following-primary-total-knee-replacement-a-pilot-study
#6
Jinwei Xie, Jun Ma, Qiang Huang, Chen Yue, Fuxing Pei
BACKGROUND This study aimed to assess whether the efficacy of tranexamic acid (TXA) would be altered when rivaroxaban or enoxaparin was used for thromboprophylaxis in primary total knee replacement (TKR). It was hypothesized that the hemostatic effect of TXA would be better with the use of enoxaparin. MATERIAL AND METHODS A randomized clinical trial was conducted on 194 patients undergoing primary TKR for osteoarthritis. An intravenous dose of 15 mg/kg (TXA) and 1 g topical TXA were used. Patients randomly received enoxaparin or rivaroxaban prophylaxis when the drainage was less than 30 ml/h 6-8 h postoperatively...
February 8, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28168348/insights-into-cellular-signalling-by-g-protein-coupled-receptor-transactivation-of-cell-surface-protein-kinase-receptors
#7
REVIEW
Rebecca Chaplin, Lyna Thach, Morley D Hollenberg, Yingnan Cao, Peter J Little, Danielle Kamato
G protein coupled receptor (GPCR) signalling is mediated by transactivation independent and transactivation dependent pathways. GPCRs transactivate protein tyrosine kinase receptors (PTKRs) and protein serine/threonine kinase receptors (PS/TKR). Since the initial observations of transactivation dependent signalling, there has been an effort to understand the mechanisms behind this phenomena. GPCR signalling has evolved to include biased signalling. Biased signalling, whereby selected ligands can activate the same GPCR that can generate multiple signals, but drive only a unique response...
February 6, 2017: Journal of Cell Communication and Signaling
https://www.readbyqxmd.com/read/28164047/management-of-infected-total-knee-arthroplasty-by-a-new-innovative-customized-articulating-knee-spacer-an-early-experience
#8
Dhiraj P Marothi, Vipin Sharma, Ashish N Sheth, Vikram I Shah, L Bharath, J A Pachore
INTRODUCTION: Management of infected total knee arthroplasty (TKA) is a challenge to patient and surgeon alike. Two-stage exchange is the universally acclaimed method to tackle this problem. Various spacer devices are available for the first stage surgery for local delivery of antibiotics. Here, we report our experience with management of infected TKA patients with our indigenously designed and produced knee spacer. CASE REPORT: Between 2012 and 2013, 28 patients with infected total knee replacement (TKR) have been managed by our indigenous knee spacer...
September 2016: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28160020/diagnosis-of-periprosthetic-joint-infection-using-alpha-defensin-test-or-multiplex-pcr-ideal-diagnostic-test-still-not-found
#9
Arnold J Suda, Marco Tinelli, Nils D Beisemann, Yoram Weil, Amal Khoury, Oliver E Bischel
PURPOSE: Diagnosing periprosthetic infection remains a challenge. Multiplex-PCR and biomarkers such as alpha-defensin are potentially useful and fast methods for detecting periprosthetic infection. This study compared these new methods with clinical assessment, conventional microbiological methods and histo-pathological examination. METHODS: Twenty-eight consecutive patients with 30 joints and a mean age of 67.7 years (range 39 to 88) with removal of total hip arthroplasty (THA) or total knee replacement (TKR) were included in this study...
February 4, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28159233/expression-and-activation-of-platelet-derived-growth-factor-%C3%AE-receptor-mitogen-activated-protein-extracellular-signal-regulated-kinase-kinase-mek-and-extracellular-signal-regulated-kinase-erk-in-canine-mammary-tumours
#10
Gennaro Altamura, Barbara Degli Uberti, Giorgio Galiero, Manuela Martano, Antonella Pirro, Marco Russo, Giuseppe Borzacchiello
Canine mammary tumours are frequent neoplasms mostly affecting intact female dogs, for which no 100% efficient therapy is available. Platelet derived growth factor β receptor (PDGFβR) is a tyrosine kinase receptor (TKR) with a potential role in human breast cancer and a series of canine tumours. In this study we demonstrated, for the first time, expression of PDGFβR and its downstream transduction molecules, mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) and extracellular signal-regulated kinase (ERK), as well as their activated forms in canine mammary tumours by both biochemical analysis and immunohistochemistry...
February 2017: Research in Veterinary Science
https://www.readbyqxmd.com/read/28155834/variation-in-the-posterior-condylar-angle
#11
Łukasz Cielmski, Damian Kusz, Michał Wójcik, Jakub Kamiński, Marcin Kusz
BACKGROUND: Clinical success of TKR depends to a large extent on the correct positioning of the implants. The femur cut is usually made in 3° of external rotation relative to the posterior aspect of the femoral condyles, which is a typical value of the Posterior Condylar Angle (PCA). The aim of this study was to assess variation in the PCA and to identify possible correlations between the value of the PCA and the following parameters: gender, body side, body height and weight (BMI). MATERIAL AND METHODS: The study group comprised 75 patients who underwent an Angio-CT study between 2012 and 2014 due to a suspected vascular disorder...
November 30, 2016: Ortopedia, Traumatologia, Rehabilitacja
https://www.readbyqxmd.com/read/28139192/is-cement-penetration-in-tkr-reduced-by-not-using-a-tourniquet-during-cementation-a-single-blinded-randomized-trial
#12
Christopher John Vertullo, Manickaraj Nagarajan
Despite suggestions that tourniquet inflation during total knee replacement reduces bleeding and hence improves cement penetration, no studies exist supporting this widely held belief. In this single-blinded, single-surgeon, randomized controlled trial, the tourniquet inflation during cementation group ( n = 20) did not have greater tibial cement penetration compared to a no tourniquet group ( n = 20). No statistically significant differences in semiautomatic digitally measured average and central radiographic tibial plateau penetration values were observed between the two groups ( p = 0...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28139190/patient-specific-instrumentation-for-total-knee-arthroplasty
#13
Arash Nabavi, Caroline M Olwill, Mike Do, Tanya Wanasawage, Ian A Harris
PURPOSE: To assess the accuracy of total knee replacements (TKRs) performed using CT-based patient-specific instrumentation by postoperative CT scan. METHOD: Approval from the Ethics Committee was granted prior to commencement of this study. Fifty prospective and consecutive patients who had undergone TKR (Evolis, Medacta International) using CT-based patient-specific instrumentation (MY KNEE, Medacta International) were assessed postoperatively using a CT scan and the validated Perth protocol measurement technique...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28139061/immunohistochemical-and-molecular-profile-of-salivary-gland-cancer-in-children
#14
Laura D Locati, Paola Collini, Martina Imbimbo, Marta Barisella, Adele Testi, Lisa F Licitra, Thomas Löning, Katharina Tiemann, Pasquale Quattrone, Emanuela Bimbatti, Stefano Chiaravalli, Michela Casanova, Elena Tamborini, Roberto Carta, Patrizia Gasparini, Marco Guzzo, Maura Massimino, Andrea Ferrari
BACKGROUND: Pediatric salivary gland carcinomas (SGCs) are very rare. They differ from the adult SGCs in terms of epidemiologic and clinical behavior, being generally limited only to selected histotypes (e.g. low-grade mucoepidermoid [LG-MEC] and acinic cell cancer [AcCC]) and characterized by very good outcome. Our aim was to investigate therapeutic targets on a series of pediatric SGCs by immunohistochemical and molecular analysis. METHODS: A retrospective analysis was performed to search for cases of pediatric SGCs in the database of the Pediatric Oncology Unit at the Istituto Nazionale Tumori and in the Pathology database at the Gerhard-Seifert-Reference-Centre...
January 31, 2017: Pediatric Blood & Cancer
https://www.readbyqxmd.com/read/28131634/comminuted-intraarticular-fractures-of-the-tibial-plateau-lead-to-posttraumatic-osteoarthritis-of-the-knee-current-treatment-review
#15
REVIEW
Matthias Aurich, Veit Koenig, Gunther Hofmann
Posttraumatic osteoarthritis (PTOA) of the knee is a common complication after intra- and extra-articular fractures. Moreover, PTOA may also be a result of isolated cartilage defects, meniscus resections, and ligament injuries. There are various methods of treatment of knee joint fractures. However, in the final stage of a PTOA, when nonoperative treatment fails, endoprosthetic joint replacement is the method of choice. Primary total knee replacement (TKR) for the treatment for a fracture of the knee joint is a rare indication, even at major treatment centers...
January 25, 2017: Asian Journal of Surgery
https://www.readbyqxmd.com/read/28127856/the-impact-of-regression-to-the-mean-on-economic-evaluation-in-quasi-experimental-pre-post-studies-the-example-of-total-knee-replacement-using-data-from-the-osteoarthritis-initiative
#16
Chris Schilling, Dennis Petrie, Michelle M Dowsey, Peter F Choong, Philip Clarke
Many treatments are evaluated using quasi-experimental pre-post studies susceptible to regression to the mean (RTM). Ignoring RTM could bias the economic evaluation. We investigated this issue using the contemporary example of total knee replacement (TKR), a common treatment for end-stage osteoarthritis of the knee. Data (n = 4796) were obtained from the Osteoarthritis Initiative database, a longitudinal observational study of osteoarthritis. TKR patients (n = 184) were matched to non-TKR patients, using propensity score matching on the predicted hazard of TKR and exact matching on osteoarthritis severity and health-related quality of life (HrQoL)...
January 27, 2017: Health Economics
https://www.readbyqxmd.com/read/28118530/current-risk-adjustment-and-comorbidity-index-underperforms-in-predicting-post-acute-utilization-and-hospital-readmissions-after-joint-replacements-implications-for-comprehensive-care-for-joint-replacement-model
#17
Amit Kumar, Amol Karmarkar, Brian Downer, Amit Vashist, Deepak Adhikari, Soham Al Snih, Kenneth Ottenbacher
OBJECTIVE: Compare the performances of comorbidity indices: Charlson, Elixhauser, and the Centers for Medicare & Medicaid Services (CMS) risk adjustment model Hierarchical Condition Category (HCC), in predicting post-acute discharge settings and hospital readmission for patients after joint replacement. METHODS: Retrospective study of Medicare beneficiaries with total knee replacement (TKR) or total hip replacement (THR) discharged from hospitals in 2009-2011 (N=607,349)...
January 24, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/28115800/a-3%C3%A2-year-minimum-follow-up-of-endoprosthetic-replacement-for-distal-femoral-fractures-an-alternative-treatment-option
#18
A Atrey, N Hussain, O Gosling, P Giannoudis, A Shepherd, S Young, J Waite
INTRODUCTION: Although the use of an endoprosthesis for distal femoral fractures remains a valid treatment option the widespread use is in its infancy. METHODOLOGY: In this retrospective case series, we review cases of distal femoral fracture treated with endoprosthetic replacement (EPR). The outcomes we assessed were the time to start mobilising, the time to discharge, morbidity and mortality as well as an Oxford knee score to assess pain and function and also the early survivorship...
March 2017: Journal of Orthopaedics
https://www.readbyqxmd.com/read/28102615/comparative-effectiveness-of-venous-thromboembolism-prophylaxis-options-for-the-patient-undergoing-total-hip-and-knee-replacement-a-network-meta-analysis
#19
A Kapoor, A Ellis, N Shaffer, J Gurwitz, A Chandramohan, J Saulino, A Ishak, T Okubanjo, F Michota, E Hylek, T A Trikalinos
: Essentials Despite trial data, guidelines have not endorsed direct oral Xa inhibitors above other options. We provide profiles of venous thromboembolism and hemorrhage risk for 12 options. Direct oral Xa inhibitors had a favorable profile compared with low-molecular-weight heparin. Other options did not have favorable profiles compared with low-molecular-weight heparin. SUMMARY: Background There are numerous trials and several meta-analyses comparing venous thromboembolism (VTE) prophylaxis options after total hip and knee replacement (THR and TKR)...
February 2017: Journal of Thrombosis and Haemostasis: JTH
https://www.readbyqxmd.com/read/28089984/achieving-consensus-on-total-joint-replacement-trial-outcome-reporting-using-the-omeract-filter-endorsement-of-the-final-core-domain-set-for-total-hip-and-total-knee-replacement-trials-for-endstage-arthritis
#20
Jasvinder A Singh, Michelle M Dowsey, Michael Dohm, Susan M Goodman, Amye L Leong, Marieke M J H Scholte Voshaar, Peter F Choong
OBJECTIVE: Discussion and endorsement of the OMERACT total joint replacement (TJR) core domain set for total hip replacement (THR) and total knee replacement (TKR) for endstage arthritis; and next steps for selection of instruments. METHODS: The OMERACT TJR working group met at the 2016 meeting at Whistler, British Columbia, Canada. We summarized the previous systematic reviews, the preliminary OMERACT TJR core domain set and results from previous surveys. We discussed preliminary core domains for TJR clinical trials, made modifications, and identified challenges with domain measurement...
January 15, 2017: Journal of Rheumatology
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