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https://www.readbyqxmd.com/read/29679749/matching-adjusted-comparisons-demonstrate-better-clinical-outcomes-with-sc-peginterferon-beta-1a-every-two-weeks-than-with-sc-interferon-beta-1a-three-times-per-week
#1
Patricia K Coyle, Shulian Shang, Zhen Xiao, Qunming Dong, Carmen Castrillo-Viguera
BACKGROUND: Subcutaneous (SC) peginterferon beta-1a and SC interferon beta-1a (IFN beta-1a) have demonstrated efficacy in treating relapsing-remitting multiple sclerosis (RRMS) but have never been compared in direct head-to-head clinical trials, the gold-standard comparison. A well-balanced matching-adjusted comparison of weighted individual patient data on SC peginterferon beta-1a, and aggregate data from published phase 3 clinical trials of SC IFN beta-1a, was conducted to provide additional information on the comparative efficacy of these two agents...
February 18, 2018: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29679730/stand-alone-lateral-lumbar-interbody-fusion-for-the-treatment-of-symptomatic-adjacent-segment-degeneration-following-previous-lumbar-fusion
#2
Philip K Louie, Arya G Varthi, Ankur S Narain, Victor Lei, Daniel D Bohl, Grant D Shifflett, Frank M Phillips
BACKGROUND CONTEXT: Revision posterior decompression and fusion for patients with symptomatic ASD is associated with significant morbidity and is technically challenging. The use of a stand-alone LLIF in patients with symptomatic ASD may avoid many of the complications associated with revision posterior surgery. PURPOSE: To assess the clinical and radiographic outcomes of patients who underwent stand-alone lateral lumbar interbody fusion (LLIF) for symptomatic adjacent segment disease (ASD)...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29679727/the-influence-of-hand-grip-strength-on-surgical-outcomes-after-surgery-for-degenerative-lumbar-spinal-stenosis-a-preliminary-result
#3
Feng Shen, Ho-Joong Kim, Na-Kyoung Lee, Heoung-Jae Chun, Bong-Soon Chang, Choon-Ki Lee, Jin S Yeom
BACKGROUND CONTEXT: Although a number of prognostic factors have been demonstrated to be associated with surgical outcome of degenerative lumbar spinal stenosis (DLSS), no study has investigated the relation between hand grip strength (HGS) and treatment outcome of DLSS. PURPOSE: The purpose of this study was to examine the influence of HGS on surgical outcomes after surgery for patients with DLSS. STUDY DESIGN: An observational study PATIENT SAMPLE: Patients who underwent spine surgery for DLSS...
April 18, 2018: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/29679493/ppars-and-pain
#4
REVIEW
Bright N Okine, Jessica C Gaspar, David P Finn
Chronic pain is a common cause of disability worldwide and remains a global health and socioeconomic challenge. Current analgesics are either ineffective in a significant proportion of patients with chronic pain, or associated with significant adverse side effects. The peroxisome proliferator-activated receptors (PPARs), a family of nuclear hormone transcription factors, have emerged as important modulators of pain in preclinical studies and therefore a potential therapeutic target for the treatment of pain...
April 21, 2018: British Journal of Pharmacology
https://www.readbyqxmd.com/read/29679188/why-do-people-help-each-other-motivations-of-volunteers-who-assisted-persons-with-disabilities-during-world-youth-day
#5
Edyta Janus, Anna Misiorek
A growing number of researchers attempt to identify the reasons why some people become volunteers. An analysis of the motives of people who helped persons with disabilities for free during World Youth Day, a renowned religious event, may contribute to this discussion. The aim of this article is to present the results of a survey encompassing 51 volunteers who assisted persons with disabilities during the 31st World Youth Day, which was held in Poland in 2016.
April 20, 2018: Journal of Religion and Health
https://www.readbyqxmd.com/read/29679136/the-pedicle-instrumentation-and-percutaneous-elevation-pi-pe-a-new-cementless-surgical-technique-in-type-a-post-traumatic-vertebral-fractures
#6
Andrea Piazzolla, Giuseppe Solarino, Davide Bizzoca, Claudia Parato, Gaetano Monteleone, Franca Dicuonzo, Biagio Moretti
PURPOSE: To investigate if bone substitutes are strictly necessary to restore the vertebral body height and improve the clinical outcome, in patients with thoracolumbar or lumbar AO type A post-traumatic vertebral fractures, managed with balloon kyphoplasty combined with posterior screw and rod system. METHODS: 105 patients with post-traumatic thoracolumbar spine fracture were recruited. At baseline, the patients underwent a CT and an MRI of the spine. Clinical evaluation was performed, using the Visual Analog Scale (VAS) and the Oswestry Disability Index (ODI), at baseline, 48 h after surgery, at 3-month follow-up (FU), 6-month FU, 48 h after the instrumentation removal and at 24-month FU...
April 20, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29679072/polyunsaturated-fatty-acids-metabolism-purine-metabolism-and-inosine-as-potential-independent-diagnostic-biomarkers-for-major-depressive-disorder-in-children-and-adolescents
#7
Xinyu Zhou, Lanxiang Liu, Xinghui Lan, David Cohen, Yuqing Zhang, Arun V Ravindran, Shuai Yuan, Peng Zheng, David Coghill, Lining Yang, Sarah E Hetrick, Xiaofeng Jiang, Jean-Jacques Benoliel, Andrea Cipriani, Peng Xie
Major depressive disorder (MDD) in children and adolescents is a recurrent and disabling condition globally but its pathophysiology remains poorly elucidated and there are limited effective treatments available. We performed metabolic profiling of plasma samples based on ultra-high-performance liquid chromatography equipped with quadrupole time-offlight mass spectrometry to explore the potential biomarkers of depression in children and adolescents with MDD. We identified several perturbed pathways, including fatty acid metabolism-particularly the polyunsaturated fatty acids metabolism, and purine metabolism-that were associated with MDD in these young patients...
April 20, 2018: Molecular Psychiatry
https://www.readbyqxmd.com/read/29678993/qualitative-longitudinal-study-of-episodic-disability-experiences-of-older-women-living-with-hiv-in-ontario-canada
#8
Patricia Solomon, Kelly K O'Brien, Stephanie Nixon, Lori Letts, Larry Baxter, Nicole Gervais
OBJECTIVES: To examine the episodic disability experiences of older women living with HIV over time. DESIGN: Qualitative longitudinal study, conducting semistructured in-depth interviews on four occasions over a 20-month time frame. Inductive thematic analyses were conducted cross-sectionally and longitudinally. SETTING: Participants were recruited from HIV community organisations in Canada. PARTICIPANTS: 10 women aged 50 years or older living with HIV for more than 6 years...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678706/mid-term-clinical-and-radiological-outcomes-after-kyphoplasty-in-the-treatment-of-thoracolumbar-traumatic-vertebral-compression-fractures
#9
Michael Grelat, Rachid Madkouri, Pierre-Olivier Comby, Elie Fahed, Brivael Lemogne, Pierre Thouant
OBJECTIVE: The management of thoracolumbar post-traumatic compression fractures widely varies among centers, and there is no real consensus. The objective of our retrospective study was to detect the progression of vertebral kyphosis in non-osteoporotic patients treated by balloon kyphoplasty (KPB) who presented recent compression fractures of the thoracolumbar region. MATERIALS AND METHODS: From 2007 to 2011, we focused in this retrospective study on the vertebral and regional kyphosis evolution in 77 patients treated by KPB for compression vertebral fractures (Magerl A)...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29678563/pilot-randomized-trial-of-integrated-cognitive-behavioral-therapy-and-neuromuscular-training-for-juvenile-fibromyalgia-the-fit-teens-program
#10
Susmita Kashikar-Zuck, William R Black, Megan Pfeiffer, James Peugh, Sara E Williams, Tracy V Ting, Staci Thomas, Katie Kitchen, Gregory D Myer
Cognitive-behavioral therapy (CBT) improves coping and daily functioning in adolescents with juvenile fibromyalgia (JFM), but is less effective in reducing pain. This pilot trial evaluated the efficacy of a novel intervention (Fibromyalgia Integrative Training for Teens; FIT Teens) which integrates CBT with specialized neuromuscular exercise training to enhance the impact of treatment on reducing pain and disability. Forty adolescents with JFM (12-18 years) were randomized to CBT-only or FIT Teens. Treatment was conducted in group-based sessions over 8 weeks with assessments at baseline, post-treatment, and 3-month follow-up (primary endpoint)...
April 17, 2018: Journal of Pain: Official Journal of the American Pain Society
https://www.readbyqxmd.com/read/29678453/latex-glove-use-among-healthcare-workers-in-australia
#11
Renee N Carey, Lin Fritschi, Timothy R Driscoll, Michael J Abramson, Deborah C Glass, Ellie Darcey, Si Si, Geza Benke, Alison Reid, Sonia El-Zaemey
BACKGROUND: Exposure to natural rubber latex, primarily through the use of gloves, is a well-recognized cause of occupational asthma. We investigated latex glove use among Australian workers and estimated the resultant burden of occupational asthma among healthcare workers (HCWs). METHODS: Data were collected in 2014 as part of the Australian Work Exposures Study-Asthma, a telephone survey investigating the prevalence of current occupational exposure to asthmagens, including latex...
April 17, 2018: American Journal of Infection Control
https://www.readbyqxmd.com/read/29678342/spending-on-health-and-hiv-aids-domestic-health-spending-and-development-assistance-in-188-countries-1995-2015
#12
(no author information available yet)
BACKGROUND: Comparable estimates of health spending are crucial for the assessment of health systems and to optimally deploy health resources. The methods used to track health spending continue to evolve, but little is known about the distribution of spending across diseases. We developed improved estimates of health spending by source, including development assistance for health, and, for the first time, estimated HIV/AIDS spending on prevention and treatment and by source of funding, for 188 countries...
April 17, 2018: Lancet
https://www.readbyqxmd.com/read/29678313/is-the-amount-of-exposure-to-aggressive-challenging-behaviour-related-to-staff-work-related-well-being-in-intellectual-disability-services-evidence-from-a-clustered-research-design
#13
Samantha Flynn, Richard P Hastings, David Gillespie, Rachel McNamara, Elizabeth Randell
BACKGROUND: Previous research has demonstrated an association between aggressive challenging behaviour (CB) and reductions in work-related well-being for intellectual disability (ID) support staff. Much of this research has used subjective measures of CB. AIMS: To examine whether exposure to aggressive CB is associated with reduced work-related well-being in staff working in ID residential settings across the UK. METHODS AND PROCEDURE: A cross-sectional analysis was undertaken as part of a randomised trial; 186 staff from 100 settings completed questionnaires on their CB self-efficacy, empathy, positive work motivation, and burnout...
April 17, 2018: Research in Developmental Disabilities
https://www.readbyqxmd.com/read/29678278/periventricular-small-cystic-lesions-in-a-patient-with-coffin-lowry-syndrome-who-exhibited-a-novel-mutation-in-the-rps6ka3-gene
#14
Yohane Miyata, Ken Saida, Satoko Kumada, Noriko Miyake, Hideaki Mashimo, Yuya Nishida, Ikuko Shirai, Eiji Kurihara, Yasuhiro Nakata, Naomichi Matsumoto
BACKGROUND: Coffin-Lowry syndrome is a rare X-linked disease, caused by loss-of-function mutations in the RPS6KA3 gene. Patients exhibit severe intellectual disability with characteristic dysmorphism. As there are no specific laboratory findings to support the diagnosis of Coffin-Lowry syndrome, it may be difficult to diagnose-especially in young children, where the characteristic craniofacial features are less discernible. CASE: Here we report on a 2-year-old boy with Coffin-Lowry syndrome with a novel missense mutation in the RPS6KA3 gene...
April 17, 2018: Brain & Development
https://www.readbyqxmd.com/read/29678257/-functional-status-as-an-independent-risk-factor-in-elderly-patients-admitted-to-an-intensive-care-unit
#15
Federico Gordo, Cristina Castro, Inés Torrejón, Sonia Bartolomé, Francisco Coca, Ana Abella
OBJECTIVE: To assess the association of previous functional status in elderly patients admitted to the ICU, estimated by the Barthel and Short Form-Late Life Function and Disability instrument scales, and the relationship with prognosis and functional capacity at hospital discharge. MATERIAL AND METHODS: Observational prospective study of ICU-admitted patients older than 74 years, with a length of stay greater than 48hours. Demographic data, social background, comorbidities, disability questionnaire (Barthel, Short Form-Late Life Function and Disability instrument), main diagnosis and severity (SAPS 3) on ICU admission were recorded...
April 17, 2018: Revista Española de Geriatría y Gerontología
https://www.readbyqxmd.com/read/29678183/a-randomized-controlled-cross-over-trial-investigating-the-effect-of-anti-inflammatory-diet-on-disease-activity-and-quality-of-life-in-rheumatoid-arthritis-the-anti-inflammatory-diet-in-rheumatoid-arthritis-adira-study-protocol
#16
Anna Winkvist, Linnea Bärebring, Inger Gjertsson, Lars Ellegård, Helen M Lindqvist
BACKGROUND: Rheumatoid arthritis (RA) is a chronic inflammatory disease that affects 0.5-1.0% of the population, and where many patients in spite of modern pharmacological treatment fail to reach remission. This affects physical as well as mental wellbeing and leads to severely reduced quality of life and reduced work capacity, thus yielding high individual as well as societal costs. As a complement to modern pharmacological treatment, lifestyle intervention should be evaluated as a treatment option...
April 20, 2018: Nutrition Journal
https://www.readbyqxmd.com/read/29678137/supporting-teams-to-optimize-function-and-independence-in-veterans-a-multi-study-program-and-mixed-methods-protocol
#17
Virginia Wang, Kelli Allen, Courtney H Van Houtven, Cynthia Coffman, Nina Sperber, Elizabeth P Mahanna, Cathleen Colón-Emeric, Helen Hoenig, George L Jackson, Teresa M Damush, Erika Price, Susan N Hastings
BACKGROUND: Successful implementation of new clinical programs depends on effectively establishing, reorganizing, or enhancing team structures and processes to coordinate the work of individuals who are interdependent in their tasks, manage relationships, and share responsibility for outcomes. However, a one-size-fits-all approach is rarely effective. In partnership with VA national clinical leaders and local clinical champions, the Optimizing Function and Independence VA Quality Enhancement Research Initiative program (Function QUERI) will evaluate efforts to implement team-based clinical programs for Veterans at risk for functional decline and disability...
April 20, 2018: Implementation Science: IS
https://www.readbyqxmd.com/read/29678126/associations-of-depression-anxiety-and-ptsd-with-neurological-disability-and-cognitive-impairment-in-survivors-of-moyamoya-disease
#18
Chanchan Liu, Xiyan Yi, Ting Li, Lei Xu, Mei Hu, Suming Zhang, Rifeng Jiang
Depression, anxiety and posttraumatic stress disorder (PTSD) are common complications of cerebrovascular diseases. However, they were seldom explored in Moyamoya Disease (MMD) survivors. In this study, we measured the prevalence of depression, anxiety and PTSD in MMD survivors. We evaluated the association of mental disorders with neurological disability and cognitive impairment, and further find out the independent protective and risk factors of neurological disability and cognitive impairment. In MMD survivors, the prevalence of these three mental disorders is high, 46...
April 20, 2018: Psychology, Health & Medicine
https://www.readbyqxmd.com/read/29678037/semi-automatically-measuring-shoulders-range-of-motion-objective-measurements-with-good-reliability-and-accuracy
#19
Birgit Saalfeld, Ilonka Pingel, Klaus-Hendrik Wolf
The shoulder's range of motion (ROM) is an important measurement for the diagnostic process and course of treatment for patients with shoulder disorders or injuries. Visual estimation to assess a shoulder's ROM is a fast measuring method, and therefore routinely used in clinical practice. Studies already proved this method as very subjective and unreliable. Misestimating the severity of a patient's disability can lead to improper treatment and should be avoided. Modern technology may help measuring the ROM more reliable, objective, non-invasive and still fast...
2018: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/29677917/clinical-similarity-based-framework-for-hospital-medical-supplies-utilization-anomaly-detection-a-case-study
#20
Ning Sun, Meilin Xu, Mingzhi Cai, Xudong Ma, Yong Qin
Healthcare systems are costly in many countries, and hospitals have always been one of the major cornerstones of the healthcare industry. Medical supplies expense is an increasingly substantial category of hospital costs. In China, the expense of medical supplies is being controlled at the hospital level. Different from drug prescription, medical supplies utilization is not being standardized or guided by clinical guidelines. In order to achieve the goal, many hospitals directly disable the use of the most expensive medical supplies...
2018: Studies in Health Technology and Informatics
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