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https://www.readbyqxmd.com/read/29245188/the-unmet-needs-of-aboriginal-australians-with-musculoskeletal-pain-a-mixed-method-systematic-review
#1
Ivan B Lin, Samantha Bunzli, Donna B Mak, Charmaine Green, Roger Goucke, Juli Coffin, Peter B O'Sullivan
OBJECTIVE: Musculoskeletal pain (MSP) conditions are the biggest cause of disability and internationally, Indigenous peoples experience a higher burden. There are conflicting reports about Aboriginal Australians and MSP. We conducted a systematic review to describe the prevalence, associated factors, impacts, care access, health care experiences, and factors associated with MSP among Aboriginal Australians. METHODS: A systematic search of quantitative and qualitative scientific and grey literature (PROSPERO number: CRD42016038342)...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29245173/patient-perception-of-disease-related-symptoms-and-complications-in-relapsing-polychondritis
#2
Marcela A Ferrada, Peter C Grayson, Shubhasree Banerjee, Keith Sikora, Robert Colbert, Ninet Sinaii, James D Katz
OBJECTIVE: To assess patient-reported symptoms and burden of disease in relapsing polychondritis (RP). METHODS: Patients with RP completed a disease-specific online survey to identify symptoms attributed to illness. Patients were divided into subgroups based upon presence or absence of ear/nose, airway, or joint involvement. Pathway to diagnosis, treatment, and disease-related complications were assessed within each subgroup. RESULTS: Data from 304 respondents were included in this analysis...
December 15, 2017: Arthritis Care & Research
https://www.readbyqxmd.com/read/29245139/scapular-focused-exercise-treatment-protocol-for-shoulder-impingement-symptoms-three-dimensional-scapular-kinematics-analysis
#3
Gisele Harumi Hotta, Adriane Lopes Santos, Kevin James McQuade, Anamaria Siriani de Oliveira
BACKGROUND: The present study aimed to describe the effects of a periscapular strengthening and neuromuscular training protocol in three-dimensional scapular kinematics and resting positioning in participants with shoulder impingement symptoms. Self-reported function was also evaluated. METHOD: The study group comprised 50 subjects with shoulder impingement syndrome (control group, n=25; treatment group, n=25). The treatment group underwent 8weeks of neuromuscular training and periscapular strengthening...
December 11, 2017: Clinical Biomechanics
https://www.readbyqxmd.com/read/29245020/killing-two-birds-with-one-stone-association-between-tobacco-and-alcohol-consumption
#4
REVIEW
A M Reis, C Quintal, Ó Lourenço
OBJECTIVES: Tobacco and excessive alcohol consumption are addictive behaviours, listed among the 10 leading risk factors that cause death and disability in the world, and health consequences are greater if their consumption is combined. There is sparse empirical evidence on the variables that influence the simultaneous consumption of tobacco and alcohol. This study aims to identify the variables that influence the joint decision to consume alcohol and tobacco, and that encourage drinkers to smoke...
December 12, 2017: Public Health
https://www.readbyqxmd.com/read/29244874/maximum-walking-speed-in-multiple-sclerosis-assessed-with-visual-perceptive-computing
#5
Anuschka Grobelny, Janina R Behrens, Sebastian Mertens, Karen Otte, Sebastian Mansow-Model, Theresa Krüger, Elona Gusho, Judith Bellmann-Strobl, Friedemann Paul, Alexander U Brandt, Tanja Schmitz-Hübsch
BACKGROUND: Gait is often impaired in people with multiple sclerosis (PwMS), but detailed assessment of gait impairment in research and care remains challenging. In a previous pilot study we reported the feasibility of visual perceptive computing (VPC) for gait assessment in PwMS using the Short Maximum Speed Walk (SMSW), which assesses gait on recording distances confined to less than 4 meters. OBJECTIVE: To investigate the equivalence of SMSW to rater-based timed 25ft...
2017: PloS One
https://www.readbyqxmd.com/read/29244823/cost-effectiveness-of-national-health-insurance-programs-in-high-income-countries-a-systematic-review
#6
Son Nghiem, Nicholas Graves, Adrian Barnett, Catherine Haden
OBJECTIVES: National health insurance is now common in most developed countries. This study reviews the evidence and synthesizes the cost-effectiveness information for national health insurance or disability insurance programs across high-income countries. DATA SOURCES: A literature search using health, economics and systematic review electronic databases (PubMed, Embase, Medline, Econlit, RepEc, Cochrane library and Campbell library), was conducted from April to October 2015...
2017: PloS One
https://www.readbyqxmd.com/read/29244821/genotyping-of-mycobacterium-leprae-for-better-understanding-of-leprosy-transmission-in-fortaleza-northeastern-brazil
#7
Amanda N B Fontes, Luana N G C Lima, Rosa M S Mota, Rosa L F Almeida, Maria A Pontes, Heitor de S Gonçalves, Cristiane C Frota, Varalakshmi D Vissa, Patrick J Brennan, Ricardo J P S Guimaraes, Carl Kendall, Ligia R F S Kerr, Philip N Suffys
Leprosy is endemic in large part of Brazil with 28,761 new patients in 2015, the second largest number worldwide and reaches 9/10.000 in highly endemic regions and 2.7/10.000 in the city of Fortaleza, Ceará, Northeast Brazil. For better understanding of risk factors for leprosy transmission, we conducted an epidemiologic study supplemented by 17 locus VNTR and SNP 1-4 typing of Mycobacterium leprae in skin biopsy samples from new multibacillary (MB) patients diagnosed at a reference center in 2009 and 2010...
December 15, 2017: PLoS Neglected Tropical Diseases
https://www.readbyqxmd.com/read/29244786/functional-assessment-as-a-predictor-of-cognitive-impairment-a-retrospective-cohort-study
#8
Gustavo Alberto Sandival Ampuero, Fernando M Runzer-Colmenares, José F Parodi
INTRODUCTION: It is estimated that major neurocognitive disorders will affect 115.4 million people by 2050, representing a significant financial burden for society. Likewise, functional dependence for basic or instrumental activities of daily life is usually a consequence of the greater prevalence of disabling pathologies, and of the progressive decrease of the physiological reserve due to aging. OBJECTIVES: To determine the ratio between the functional test and prediction of deterioration of cognitive function in geriatric patients...
December 12, 2017: Medwave
https://www.readbyqxmd.com/read/29244736/frequency-of-fruit-and-vegetable-consumption-and-the-oral-health-related-quality-of-life-among-japanese-elderly-a-cross-sectional-study-from-the-kyoto-kameoka-study
#9
Hinako Nanri, Yosuke Yamada, Aya Itoi, Emi Yamagata, Yuya Watanabe, Tsukasa Yoshida, Motoko Miyake, Heiwa Date, Kazuko Ishikawa-Takata, Mitsuyoshi Yoshida, Takeshi Kikutani, Misaka Kimura
OBJECTIVE: Many previous studies have reported that fruit and vegetable consumption is associated with a reduced risk of various disease, but whether or not their consumption is associated with the oral health-related quality of life (OHRQoL) is unclear. The objective of this study was to examine the association between the frequency of fruit and vegetable consumption and the OHRQoL in elderly subjects by sex. METHODS: We analyzed cross-sectional data from a population-based Kyoto-Kameoka Study in 2012 of 3112 men and 3439 women (age ≥ 65 years)...
December 15, 2017: Nutrients
https://www.readbyqxmd.com/read/29244705/arthroscopic-repair-of-recurrent-posterior-shoulder-subluxation-after-total-shoulder-arthroplasty-a-case-report
#10
Ricardo Grieshaber-Bouyer, Christian Gerber
CASE: A 53-year-old man presented with osteoarthritis (Walch biconcave [B2] glenoid retroversion, 22°; glenohumeral subluxation index, 65%) and a partial rupture of the supraspinatus tendon in the left shoulder. Following anatomic total joint replacement, he developed disabling recurrent posterior subluxation despite a stable prosthesis and a correctly centered glenoid head, as observed with postoperative radiography and computed tomography. In order to avoid bone loss and the complications associated with revision arthroplasty, we performed arthroscopic reefing of the posterior capsule as an experimental minimally invasive treatment...
July 2017: JBJS Case Connector
https://www.readbyqxmd.com/read/29244240/b-cell-therapy-for-multiple-sclerosis-entering-an-era
#11
REVIEW
Ariele L Greenfield, Stephen L Hauser
Monoclonal antibodies that target CD20 expressing B cells represent an important new treatment option for patients with multiple sclerosis (MS). B cell depleting therapy is highly effective against relapsing forms of the disease, and is also the first treatment approach proven to protect against disability worsening in primary progressive MS. Moreover, evolving clinical experience with B cell therapy, combined with a more sophisticated understanding of humoral immunity in preclinical models and in patients with MS, have led to major progress in deciphering the immune pathogenesis of MS...
December 15, 2017: Annals of Neurology
https://www.readbyqxmd.com/read/29244235/new-therapy-for-refractory-chronic-mechanical-low-back-pain-restorative-neurostimulation-to-activate-the-lumbar-multifidus-one-year-results-of-a-prospective-multicenter-clinical-trial
#12
REVIEW
Kristiaan Deckers, Kris De Smedt, Bruce Mitchell, David Vivian, Marc Russo, Peter Georgius, Matthew Green, John Vieceli, Sam Eldabe, Ashish Gulve, Jean-Pierre van Buyten, Iris Smet, Vivek Mehta, Shankar Ramaswamy, Ganesan Baranidharan, Richard Sullivan, Robert Gassin, James Rathmell, Chris Gilligan
OBJECTIVES: The purpose of the international multicenter prospective single arm clinical trial was to evaluate restorative neurostimulation eliciting episodic contraction of the lumbar multifidus for treatment of chronic mechanical low back pain (CMLBP) in patients who have failed conventional therapy and are not candidates for surgery or spinal cord stimulation (SCS). MATERIALS AND METHODS: Fifty-three subjects were implanted with a neurostimulator (ReActiv8, Mainstay Medical Limited, Dublin, Ireland)...
December 15, 2017: Neuromodulation: Journal of the International Neuromodulation Society
https://www.readbyqxmd.com/read/29244146/ezh2-mutations-found-in-the-weaver-overgrowth-syndrome-cause-a-partial-loss-of-h3k27-histone-methyltransferase-activity
#13
Julian C Lui, Kevin M Barnes, Lijin Dong, Shanna Yue, Evan Graber, Robert Rapaport, Andrew Dauber, Ola Nilsson, Jeffrey Baron
Context: Weaver syndrome is characterized by tall stature, advanced bone age, characteristic facies, and variable intellectual disability. It is caused by heterozygous mutations in EZH2, a histone methyltransferase responsible for H3K27 trimethylation. However, no early truncating mutations have been identified, suggesting that null mutations do not cause Weaver syndrome. Objective: To test alternative hypotheses that EZH2 variants found in Weaver syndrome either cause a gain of function or a partial loss of function...
December 13, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29244057/measuring-frailty-in-medicare-data-development-and-validation-of-a-claims-based-frailty-index
#14
Dae Hyun Kim, Sebastian Schneeweiss, Robert J Glynn, Lewis A Lipsitz, Kenneth Rockwood, Jerry Avorn
Background: Frailty is a key determinant of health status and outcomes of health care interventions in older adults that is not readily measured in Medicare data. This study aimed to develop and validate a claims-based frailty index (CFI). Methods: We used data from Medicare Current Beneficiary Survey 2006 (development sample: n = 5,593) and 2011 (validation sample: n = 4,424). A CFI was developed using the 2006 claims data to approximate a survey-based frailty index (SFI) calculated from the 2006 survey data as a reference standard...
December 13, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29243999/efficacy-of-intraoperative-epidural-triamcinolone-application-in-lumbar-microdiscectomy-a-matched-control-study
#15
Martin N Stienen, Holger Joswig, Ivan Chau, Marian C Neidert, David Bellut, Thomas Wälchli, Karl Schaller, Oliver P Gautschi
OBJECTIVE The purpose of this study was to investigate whether the intraoperative application of an epidural steroid (ES) on the decompressed nerve root improves short- and midterm subjective and objective clinical outcomes after lumbar microdiscectomy. METHODS This study was a retrospective analysis of a 2-center database including consecutive cases in which patients underwent lumbar microdiscectomy. All patients who received ES application (40 mg triamcinolone, ES group) were matched by age and sex to patients who had not received ES application (control group)...
December 15, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29243819/novel-dietary-supplement-associationreduces-symptoms-in-endometriosis-patients
#16
Pietro Giulio Signorile, Rosa Viceconte, Alfonso Baldi
Endometriosis is characterized by disabling symptoms that afflict young women with severe physical discomfort, difficulty in relationship life, and infertility; however, the currently available therapeutic strategies are unsatisfactory. Goal of this research was to identify a new combination of natural active ingredients that, administered as dietary supplements, could have the effect of reducing inflammatory response in endometriosis patients, decreasing the symptoms the disease produces and its harmful effects on affected organs...
December 15, 2017: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29243805/interactive-media-as-a-tool-for-reducing-waiting-anxiety-at-paediatric-rehabilitation-hospitals-a-randomized-controlled-trial
#17
Elaine Biddiss, Tara Joy Knibbe, Darcy Fehlings, Patricia Mckeever, Ashley Cohen, Amy Mcpherson
AIM: To investigate the efficacy of waiting room media for reducing anxiety and increasing satisfaction at a paediatric rehabilitation hospital. METHOD: In this clustered, parallel, randomized controlled trial, 310 young people with disabilities (age range 5-19y) and their parents attending outpatient clinics were assigned to interactive media (n=113), a silent nature video (n=97), or media-free comparison (n=100) groups. Young person and parent anxiety was reported using the State-Trait Anxiety Inventory (STAI) on arrival and after 10 minutes in the waiting space...
December 15, 2017: Developmental Medicine and Child Neurology
https://www.readbyqxmd.com/read/29243770/adipose-derived-stem-cells-in-articular-cartilage-regeneration-current-concepts-and-optimization-strategies
#18
REVIEW
Xingjian Gu, Caixin Li, Feng Yin, Guanghua Yang
Knee osteoarthritis (KOA) is the most common progressive joint disorder associated with disability in the world. As a chronic disease, KOA has multifactorial etiology. However, the poor self-healing ability of the articular cartilage due to its intrinsic tissue hypovascularity and hypocellularity seems to be directly incriminated in the physio-pathological mechanism of KOA. While conventional therapies result in unfavorable clinical outcomes, regenerative cell therapies have shown great promise in articular cartilage regeneration...
December 15, 2017: Histology and Histopathology
https://www.readbyqxmd.com/read/29243538/antineoplastic-agents-exacerbating-charcot-marie-tooth-disease-red-flags-to-avoid-permanent-disability
#19
M J Ibañez-Juliá, G Berzero, G Reyes-Botero, T Maisonobe, T Lenglet, M Slim, S Louis, A Balaguer, M Sanson, E Le Guern, P Latour, D Ricard, T Stojkovic, D Psimaras
BACKGROUND: Charcot Marie Tooth (CMT) disease is the most common form of hereditary neuropathy. Due to the high prevalence of mild and undiagnosed forms, patients with CMT disease may be exposed to severe neurotoxicity following the administration of neurotoxic chemotherapies. The aim of this report is to alert oncologists to the potential to precipitate severe irreversible peripheral neuropathies when administering neurotoxic compounds to undiagnosed CMT patients. MATERIAL AND METHODS: A retrospective research in the OncoNeuroTox database was performed (2010-2016), searching for patients with the diagnosis of chemotherapy-induced peripheral neuropathy (CIPN) and CMT disease...
December 15, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/29243461/physicians-working-conditions-health-and-working-capacity
#20
Marko Elovainio, Marianna Virtanen, Tuula Oksanen
Changes in the working environment will also influence the work of physicians. The greatest of these changes on the Finnish scale, the SOTE reform (the reform in social welfare and public health services), still lies ahead. Labor shortage, on-call duties and patient record systems providing little support to work add to the burden. In surveys related to psychosocial working conditions, physicians' greatest work load factors have been rush, forced working pace and poor communication despite the fact that, on average, they consider their working conditions to be good, frequently better than those of other professional groups, and are committed to carry on with their work until retirement age...
2017: Duodecim; Lääketieteellinen Aikakauskirja
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