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https://www.readbyqxmd.com/read/29330202/high-risk-tp53-mutations-are-associated-with-extra-nodal-extension-ene-in-oral-cavity-squamous-cell-carcinoma-oscc
#1
Vlad C Sandulache, Chieko Michikawa, Pranav Kataria, Frederico O Gleber-Netto, Diana Bell, Sanchit Trivedi, Xiayu Rao, Jing Wang, Mei Zhao, Samar A Jasser, Jeffrey N Myers, Curtis R Pickering
PURPOSE:   Development of extra-nodal extension (ENE) has been associated with poor survival in patients with oral cavity squamous cell carcinoma (OSCC). Here we sought to confirm the role of ENE as a poor prognostic factor, and identify genomic and epigenetic markers of ENE in order to develop a predictive model and improve treatment selection. EXPERIMENTAL DESIGN: An institutional cohort (University of Texas MD Anderson Cancer Center) was utilized to confirm the impact of ENE on clinical outcomes and evaluate the genomic signature of primary and ENE containing tissue...
January 12, 2018: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/29329750/women-and-the-experience-of-pain-and-opioid-use-disorder-a-literature-based-commentary
#2
Andrew L Koons, Marna Rayl Greenberg, Robert D Cannon, Gillian A Beauchamp
It is generally understood that pain experience and opioid abuse have relied on male-dominated models. However, sex and gender play a role in both pain experience and opioid use disorder. Using the previously validated Texas Tech University Health Sciences Center Sex and Gender Specific Health PubMed Advanced Search Tool, the authors used pertinent literature to develop this literature-based commentary on sex and gender differences in pain experience and opioid use disorder. Women report their experience of pain more frequently, have increased rates of diagnoses related to pain, have increased pain sensitivity, and have a variable response to pain and analgesia...
January 9, 2018: Clinical Therapeutics
https://www.readbyqxmd.com/read/29326970/revisiting-sweat-chloride-test-results-based-on-recent-guidelines-for-diagnosis-of-cystic-fibrosis
#3
Jayson V Pagaduan, Mahesheema Ali, Michael Dowlin, Liye Suo, Tabitha Ward, Fadel Ruiz, Sridevi Devaraj
Objectives: Recent sweat chloride guidelines published by the Cystic Fibrosis Foundation changed the intermediate sweat chloride concentration range from 40-59 mmol/L to 30-59 mmol/L for age > 6 months. We wanted to know how this new guideline would impact detection of cystic fibrosis among patients who previously had sweat tests done at Texas Children's Hospital. Methods: We revisited sweat chloride test results (n = 3012) in the last 5 years at Texas Children's Hospital based on the new guidelines on diagnosis of cystic fibrosis from the Cystic Fibrosis Foundation...
March 2018: Practical Laboratory Medicine
https://www.readbyqxmd.com/read/29326285/prevalence-of-aflatoxin-associated-tp53r249s-mutation-in-hepatocellular-carcinoma-in-hispanics-in-south-texas
#4
Jingjing Jiao, Weibo Niu, Ying Wang, Keith Baggerly, Yuanqing Ye, Xifeng Wu, Dewitt Davenport, Jose Luis Almeda, Monica M Betancourt-Garcia, R Armour Forse, Heather L Stevenson, Gordon P Watt, Joseph B McCormick, Susan P Fisher-Hoch, Laura Beretta
We aimed to determine whether aflatoxin dietary exposure plays a role in the high incidence of hepatocellular carcinoma (HCC) observed among Hispanics in South Texas. We measured TP53R249S somatic mutation, hallmark of aflatoxin etiology in HCC, using droplet digital PCR and RFLP. TP53R249S mutation was detected in 3 of 41 HCC tumors from Hispanics in South Texas (7.3%). We also measured TP53R249S mutation in plasma cell-free DNA (cfDNA) from 218 HCC patients and 96 Hispanic subjects with advanced fibrosis or cirrhosis, from South Texas...
January 11, 2018: Cancer Prevention Research
https://www.readbyqxmd.com/read/29324929/our-solution-for-fusion-of-simultaneusly-acquired-whole-body-scintigrams-and-optical-images-as-usesful-tool-in-clinical-practice-in-patients-with-differentiated-thyroid-carcinomas-after-radioiodine-therapy-a-useful-tool-in-clinical-practice
#5
Milovan Matovic, Milica Jankovic, Marko Barjaktarovic, Marija Jeremic
OBJECTIVE: After radioiodine therapy of differentiated thyroid cancer (DTC) patients, whole body scintigraphy (WBS) is standard procedure before releasing the patient from the hospital. A common problem is the precise localization of regions where the iod-avide tissue is located. Sometimes is practically impossible to perform precise topographic localization of such regions. METHOD: In order to face this problem, we have developed a low-cost Vision-Fusion system for web-camera image acquisition simultaneously with routine scintigraphic whole body acquisition including the algorithm for fusion of images given from both cameras...
September 2017: Hellenic Journal of Nuclear Medicine
https://www.readbyqxmd.com/read/29324902/potential-impact-of-neonicotinoid-use-on-northern-bobwhite-colinus-virginianus-in-texas-a-historical-analysis
#6
Hannah M H Ertl, Miguel A Mora, Donald J Brightsmith, Jorge A Navarro-Alberto
The widespread use of neonicotinoid insecticides in recent years has led to increasing environmental concern, including impacts to avian populations. In Texas and across their range, Northern bobwhite (Colinus virginianus) habitat frequently overlaps cultivated cropland protected by neonicotinoids. To address the effects of neonicotinoid use on bobwhites in Texas, we conducted a historical analysis from 1978-2012 in Texas' ecological regions using quail count data collected from North American Breeding Bird Survey and Texas Parks and Wildlife Department, and neonicotinoid use data from the U...
2018: PloS One
https://www.readbyqxmd.com/read/29323781/soil-phosphorus-does-not-keep-pace-with-soil-carbon-and-nitrogen-accumulation-following-woody-encroachment
#7
Yong Zhou, Thomas W Boutton, X Ben Wu
Soil carbon, nitrogen, and phosphorus cycles are strongly interlinked and controlled through biological processes, and the phosphorus cycle is further controlled through geochemical processes. In dryland ecosystems, woody encroachment often modifies soil carbon, nitrogen, and phosphorus stores, although it remains unknown if these three elements change proportionally in response to this vegetation change. We evaluated proportional changes and spatial patterns of soil organic carbon (SOC), total nitrogen (TN), and total phosphorus (TP) concentrations following woody encroachment by taking spatially-explicit soil cores to a depth of 1...
January 11, 2018: Global Change Biology
https://www.readbyqxmd.com/read/29322572/burnout-among-direct-care-workers-in-nursing-homes-influences-of-organizational-work-place-interpersonal-and-personal-characteristics
#8
Dale E Yeatts, Gul Seckin, Yuying Shen, Michael Thompson, Dana Auden, Cynthia M Cready
AIMS AND OBJECTIVES: The many negative effects of burnout have prompted researchers to better understand the factors contributing to it. The purpose of this paper is to add to this body of knowledge through the study of burnout among direct care workers (DCWs) in nursing homes (NH). BACKGROUND: Perhaps the factor most often associated with employee burnout is the level of staffing-insufficient staffing results in work overload and eventually employee burnout. A closer look at research findings suggest that there are many other factors also contributing to burnout...
January 10, 2018: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/29319841/can-texas-do-death-better
#9
Sean Price
Filling out death certificates can be confusing for Texas physicians, and vital health information often gets left off of forms. Because of this, officials don't have accurate information on how Texans are dying.
January 1, 2018: Texas Medicine
https://www.readbyqxmd.com/read/29319840/does-texas-need-more-medical-schools
#10
Sean Price
By 2020, Texas will be opening three new medical schools. Will there be enough residency positions for all the new students?
January 1, 2018: Texas Medicine
https://www.readbyqxmd.com/read/29319839/are-you-experienced
#11
Joey Berlin
A case going before the Texas Supreme Court spotlights the Medical Disclosure Panel and what physicians must disclose before performing a procedure.
January 1, 2018: Texas Medicine
https://www.readbyqxmd.com/read/29319838/questions-abound
#12
Joey Berlin
The Texas Medical Board's new rules on inspecting clinics for failure to register as pain management clinics have provisions of potential concern for doctors.
January 1, 2018: Texas Medicine
https://www.readbyqxmd.com/read/29319837/medicaid-credentialing-made-simple
#13
Sean Price
A new partnership by the Texas Medical Association and the Texas Association of Health Plans will soon streamline the process of getting credentialed - and recredentialed - for Medicaid health plans.
January 1, 2018: Texas Medicine
https://www.readbyqxmd.com/read/29319690/texas-displays-silicon-valley-credentials-to-lure-brazilian-biotechs
#14
Melanie Senior
No abstract text is available yet for this article.
January 10, 2018: Nature Biotechnology
https://www.readbyqxmd.com/read/29319585/which-us-states-pose-the-greatest-threats-to-military-readiness-and-public-health-public-health-policy-implications-for-a-cross-sectional-investigation-of-cardiorespiratory-fitness-body-mass-index-and-injuries-among-us-army-recruits
#15
Daniel B Bornstein, George L Grieve, Morgan N Clennin, Alexander C McLain, Laurie P Whitsel, Michael W Beets, Keith G Hauret, Bruce H Jones, Mark A Sarzynski
OBJECTIVE: Many states in the southern region of the United States are recognized for higher rates of obesity, physical inactivity, and chronic disease. These states are therefore recognized for their disproportionate public health burden. The purpose of this study was to investigate state-level distributions of cardiorespiratory fitness, body mass index (BMI), and injuries among US Army recruits in order to determine whether or not certain states may also pose disproportionate threats to military readiness and national security...
January 9, 2018: Journal of Public Health Management and Practice: JPHMP
https://www.readbyqxmd.com/read/29319393/sex-based-differences-in-discharge-disposition-and-outcomes-for-st-segment-elevation-myocardial-infarction-patients-within-a-regional-network
#16
James R Langabeer, Timothy D Henry, Raymond Fowler, Tiffany Champagne-Langabeer, Junghyun Kim, Alice K Jacobs
BACKGROUND: It is known that women with ST-segment elevation myocardial infarction (STEMI) have higher mortality in comparison to men. While the reasons for this sex-based difference are not completely understood, biologic differences and disparities in care have been implicated. Whether these differences persist within an urban, regional STEMI system of care with defined protocols is unclear. Our objective was to explore sex-related effects in outcomes in a large regional system of care...
January 10, 2018: Journal of Women's Health
https://www.readbyqxmd.com/read/29317001/video-based-learning-vs-traditional-lecture-for-instructing-emergency-medicine-residents-in-disaster-medicine-principles-of-mass-triage-decontamination-and-personal-protective-equipment
#17
Henry A Curtis, Karen Trang, Kevin W Chason, Paul D Biddinger
Introduction Great demands have been placed on disaster medicine educators. There is a need to develop innovative methods to educate Emergency Physicians in the ever-expanding body of disaster medicine knowledge. The authors sought to demonstrate that video-based learning (VBL) could be a promising alternative to traditional learning methods for teaching disaster medicine core competencies. Hypothesis/Problem The objective was to compare VBL to traditional lecture (TL) for instructing Emergency Medicine residents in the American College of Emergency Physicians (ACEP; Irving, Texas USA) disaster medicine core competencies of patient triage and decontamination...
January 10, 2018: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/29314209/trends-in-texas-maternal-mortality-by-maternal-age-race-ethnicity-and-cause-of-death-2006-2015
#18
Marian F MacDorman, Eugene Declercq, Marie E Thoma
BACKGROUND: Maternal mortality is a sentinel indicator of health care quality. Our purpose was to analyze trends in Texas maternal mortality by demographic characteristics and cause of death, and to evaluate data quality. METHODS: Maternal mortality data were initially analyzed by single years, but then were grouped into 5-year averages (2006-2010 and 2011-2015) for more detailed analyses. Rates were computed per 100 000 live births. A two-proportion z test or Poisson regression for numerators <30 was used to evaluate differences...
January 4, 2018: Birth
https://www.readbyqxmd.com/read/29314069/co-occurring-woody-species-have-diverse-hydraulic-strategies-and-mortality-rates-during-an-extreme-drought
#19
Daniel M Johnson, Jean-Christophe Domec, Z Carter Berry, Amanda M Schwantes, David R Woodruff, Katherine A McCulloh, H Wayne Polley, Remí Wortemann, Jennifer J Swenson, D Scott Mackay, Nate G McDowell, Robert B Jackson
From 2011 to 2013, Texas experienced its worst drought in recorded history. This event provided a unique natural experiment to assess species-specific responses to extreme drought and mortality of four co-occurring woody species: Quercus fusiformis, Diospyros texana, Prosopis glandulosa and Juniperus ashei. We examined hypothesized mechanisms that could promote these species' diverse mortality patterns using post-drought measurements on surviving trees coupled to retrospective process modeling. The species exhibited a wide range of gas exchange responses, hydraulic strategies, and mortality rates...
January 4, 2018: Plant, Cell & Environment
https://www.readbyqxmd.com/read/29313974/genetic-variants-in-rora-and-dnmt1-associated-with-cutaneous-melanoma-survival
#20
Bo Li, Yanru Wang, Yinghui Xu, Hongliang Liu, Wendy Bloomer, Dakai Zhu, Christopher I Amos, Shenying Fang, Jeffrey E Lee, Xin Li, Jiali Han, Qingyi Wei
Cutaneous melanoma (CM) is considered as a steroid hormone-related malignancy. However, few studies have evaluated the roles of genetic variants encoding steroid hormone receptor genes and their related regulators (SHR-related genes) in CM-specific survival (CMSS). Here, we performed a pathway-based analysis to evaluate genetic variants of 191 SHR-related genes in 858 CMSS patients using a dataset from a genome-wide association study (GWAS) from The University of Texas MD Anderson Cancer Center (MDACC), and then validated the results in an additional dataset of 409 patients from the Harvard GWAS...
January 4, 2018: International Journal of Cancer. Journal International du Cancer
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