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https://www.readbyqxmd.com/read/27785002/european-society-for-swallowing-disorders-european-union-geriatric-medicine-society-white-paper-oropharyngeal-dysphagia-as-a-geriatric-syndrome
#1
REVIEW
Laura Wj Baijens, Pere Clavé, Patrick Cras, Olle Ekberg, Alexandre Forster, Gerald F Kolb, Jean-Claude Leners, Stefano Masiero, Jesús Mateos-Nozal, Omar Ortega, David G Smithard, Renée Speyer, Margaret Walshe
This position document has been developed by the Dysphagia Working Group, a committee of members from the European Society for Swallowing Disorders and the European Union Geriatric Medicine Society, and invited experts. It consists of 12 sections that cover all aspects of clinical management of oropharyngeal dysphagia (OD) related to geriatric medicine and discusses prevalence, quality of life, and legal and ethical issues, as well as health economics and social burden. OD constitutes impaired or uncomfortable transit of food or liquids from the oral cavity to the esophagus, and it is included in the World Health Organization's classification of diseases...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/27571768/recognizing-the-importance-of-dysphagia-stumbling-blocks-and-stepping-stones-in-the-twenty-first-century
#2
Rainer Dziewas, Anne Marie Beck, Pere Clave, Shaheen Hamdy, Hans Jürgen Heppner, Susan E Langmore, Andreas Leischker, Rosemary Martino, Petra Pluschinski, Andreas Roesler, Reza Shaker, Tobias Warnecke, Cornel Christian Sieber, Dorothee Volkert, Rainer Wirth
No abstract text is available yet for this article.
August 29, 2016: Dysphagia
https://www.readbyqxmd.com/read/27503566/a-comparative-study-between-two-sensory-stimulation-strategies-after-two-weeks-treatment-on-older-patients-with-oropharyngeal-dysphagia
#3
Omar Ortega, Laia Rofes, Alberto Martin, Viridiana Arreola, Irene López, Pere Clavé
Oropharyngeal dysphagia (OD) is a prevalent geriatric syndrome. Treatment is based on compensatory strategies to avoid complications. New treatments based on sensory stimulation to promote the recovery of the swallowing function have proved effective in acute studies but prolonged treatment needs further research. Our aim was to evaluate and compare the effect of two, longer-term sensory treatment strategies on older patients with OD. 38 older patients (≥70 years) were studied with videofluoroscopy (pre/posttreatment) and randomized into two 10-day treatment groups: Group A-transient receptor potential vanilloid 1 (TRPV1) agonist (capsaicin 1 × 10(-5) M) and Group B-transcutaneous sensory electrical stimulation (TSES) (Intelect VitalStim, biphasic pulses, 300 μs, 80 Hz)...
October 2016: Dysphagia
https://www.readbyqxmd.com/read/27499393/nutritional-status-of-older-patients-with-oropharyngeal-dysphagia-in-a-chronic-versus-an-acute-clinical-situation
#4
Silvia Carrión, Maria Roca, Alicia Costa, Viridiana Arreola, Omar Ortega, Elisabet Palomera, Mateu Serra-Prat, Mateu Cabré, Pere Clavé
BACKGROUND: Oropharyngeal dysphagia (OD) is a prevalent risk factor for malnutrition (MN) in older patients and both conditions are related to poor outcome. OBJECTIVE: To explore the nutritional status in older patients with OD in a chronic and an acute clinical situation. DESIGN: We examined 95 older (≥70 years) patients with OD associated to chronic neurological diseases or aging, and 23 older patients with OD and acute community-acquired pneumonia (CAP) with videofluoroscopy; and 15 older people without OD...
July 26, 2016: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/27444733/erratum-to-effect-of-bolus-viscosity-on-the-safety-and-efficacy-of-swallowing-and-the-kinematics-of-the-swallow-response-in-patients-with-oropharyngeal-dysphagia-white-paper-by-the-european-society-for-swallowing-disorders-essd
#5
https://www.readbyqxmd.com/read/27442852/oropharyngeal-and-laryngeal-sensory-innervation-in-the-pathophysiology-of-swallowing-disorders-and-sensory-stimulation-treatments
#6
Daniel Alvarez-Berdugo, Laia Rofes, J Francesc Casamitjana, Andreína Padrón, Miquel Quer, Pere Clavé
Oropharyngeal dysphagia (OD) affects older and neurological patients, causing malnutrition and dehydration and increasing the risk for aspiration pneumonia. There is evidence that sensory deficits in those populations are closely related to swallowing disorders, and several research groups are developing new therapies based on sensory stimulation of this area. More information on the sensory innervation participating in the swallow response is needed to better understand the pathophysiology of OD and to develop new treatments...
September 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27398981/neurorehabilitation-strategies-for-poststroke-oropharyngeal-dysphagia-from-compensation-to-the-recovery-of-swallowing-function
#7
Christopher Cabib, Omar Ortega, Hatice Kumru, Ernest Palomeras, Natalia Vilardell, Daniel Alvarez-Berdugo, Desirée Muriana, Laia Rofes, Rosa Terré, Fermín Mearin, Pere Clavé
Oropharyngeal dysphagia (OD) is very prevalent among poststroke patients, causing severe complications but lacking specific neurorehabilitation treatment. This review covers advances in the pathophysiology, diagnosis, and physiologically based neurorehabilitation strategies for poststroke OD. The pathophysiology of oropharyngeal biomechanics can be assessed by videofluoroscopy, as delayed laryngeal vestibule closure is closely associated with aspiration. Stroke may affect afferent or efferent neuronal circuits participating in deglutition...
July 11, 2016: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/27165955/pharyngeal-electrical-stimulation-for-treatment-of-dysphagia-in-subacute-stroke-a-randomized-controlled-trial
#8
Philip M Bath, Polly Scutt, Jo Love, Pere Clavé, David Cohen, Rainer Dziewas, Helle K Iversen, Christian Ledl, Suzanne Ragab, Hassan Soda, Anushka Warusevitane, Virginie Woisard, Shaheen Hamdy
BACKGROUND AND PURPOSE: Dysphagia is common after stroke, associated with increased death and dependency, and treatment options are limited. Pharyngeal electric stimulation (PES) is a novel treatment for poststroke dysphagia that has shown promise in 3 pilot randomized controlled trials. METHODS: We randomly assigned 162 patients with a recent ischemic or hemorrhagic stroke and dysphagia, defined as a penetration aspiration score (PAS) of ≥3 on video fluoroscopy, to PES or sham treatment given on 3 consecutive days...
June 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27016216/effect-of-bolus-viscosity-on-the-safety-and-efficacy-of-swallowing-and-the-kinematics-of-the-swallow-response-in-patients-with-oropharyngeal-dysphagia-white-paper-by-the-european-society-for-swallowing-disorders-essd
#9
EDITORIAL
Roger Newman, Natàlia Vilardell, Pere Clavé, Renée Speyer
BACKGROUND: Fluid thickening is a well-established management strategy for oropharyngeal dysphagia (OD). However, the effects of thickening agents on the physiology of impaired swallow responses are not fully understood, and there is no agreement on the degree of bolus thickening. AIM: To review the literature and to produce a white paper of the European Society for Swallowing Disorders (ESSD) describing the evidence in the literature on the effect that bolus modification has upon the physiology, efficacy and safety of swallowing in adults with OD...
April 2016: Dysphagia
https://www.readbyqxmd.com/read/26966356/oropharyngeal-dysphagia-in-older-persons-from-pathophysiology-to-adequate-intervention-a-review-and-summary-of-an-international-expert-meeting
#10
REVIEW
Rainer Wirth, Rainer Dziewas, Anne Marie Beck, Pere Clavé, Shaheen Hamdy, Hans Juergen Heppner, Susan Langmore, Andreas Herbert Leischker, Rosemary Martino, Petra Pluschinski, Alexander Rösler, Reza Shaker, Tobias Warnecke, Cornel Christian Sieber, Dorothee Volkert
Oropharyngeal dysphagia (OD) is a highly prevalent and growing condition in the older population. Although OD may cause very severe complications, it is often not detected, explored, and treated. Older patients are frequently unaware of their swallowing dysfunction which is one of the reasons why the consequences of OD, ie, aspiration, dehydration, and malnutrition, are regularly not attributed to dysphagia. Older patients are particularly vulnerable to dysphagia because multiple age-related changes increase the risk of dysphagia...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/26486375/quality-of-life-differences-in-female-and-male-patients-with-fecal-incontinence
#11
Lluís Mundet, Yolanda Ribas, Sandra Arco, Pere Clavé
BACKGROUND/AIMS: To explore and compare quality of life (QoL) differences in female and male patients with fecal incontinence. METHODS: Ninety-one patients with fecal incontinence (60 women, mean (SD) age 64.13 (9.72) years; 31 men, mean (SD) age 63.61 (13.33) years) were assessed for pathophysiology (anorectal manometry and ultrasound), clinical severity (Wexner and Vaizey scales), QoL (Fecal Incontinence Quality of Life Score [FIQL]) and health status (EQ-5D)...
January 31, 2016: Journal of Neurogastroenterology and Motility
https://www.readbyqxmd.com/read/26201818/sleeve-gastrectomy-effects-on-hunger-satiation-and-gastrointestinal-hormone-and-motility-responses-after-a-liquid-meal-test
#12
Esther Mans, Mateu Serra-Prat, Elisabet Palomera, Xavier Suñol, Pere Clavé
BACKGROUND: The relation between hunger, satiation, and integrated gastrointestinal motility and hormonal responses in morbidly obese patients after sleeve gastrectomy has not been determined. OBJECTIVE: The objective was to assess the effects of sleeve gastrectomy on hunger, satiation, gastric and gallbladder motility, and gastrointestinal hormone response after a liquid meal test. DESIGN: Three groups were studied: morbidly obese patients (n = 16), morbidly obese patients who had had sleeve gastrectomy (n = 8), and nonobese patients (n = 16)...
September 2015: American Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/25850008/dysphagia-current-reality-and-scope-of-the-problem
#13
REVIEW
Pere Clavé, Reza Shaker
Dysphagia is a symptom of swallowing dysfunction that occurs between the mouth and the stomach. Although oropharyngeal dysphagia is a highly prevalent condition (occurring in up to 50% of elderly people and 50% of patients with neurological conditions) and is associated with aspiration, severe nutritional and respiratory complications and even death, most patients are not diagnosed and do not receive any treatment. By contrast, oesophageal dysphagia is less prevalent and less severe, but with better recognized symptoms caused by diseases affecting the enteric nervous system and/or oesophageal muscular layers...
May 2015: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/25459191/clinical-usefulness-of-therapeutic-drug-monitoring-of-voriconazole-in-a-university-hospital
#14
Evelyn Cabral-Galeano, Isabel Ruiz-Camps, Oscar Len-Abad, Leonor Pou-Clavé, Roger Sordé-Masip, Yolanda Meije-Castillo, Albert Blanco-Grau, Pere Barba-Suñol, Victor Monforte-Torres, Antonio Román-Broto, Albert Pahissa-Berga, Joan Gavaldà-Santapau
INTRODUCTION: The aim of this study was to assess the clinical usefulness of therapeutic drug monitoring (TDM) of voriconazole (VOR) in a university hospital. METHODS: A retrospective review was conducted on the clinical records of 52 patients treated with VOR and on whom TDM was performed. Steady-state trough plasma VOR concentration was measured at least 5 days after starting treatment. The therapeutic range of plasma VOR concentration was defined as 1-5.5μg/mL...
May 2015: Enfermedades Infecciosas y Microbiología Clínica
https://www.readbyqxmd.com/read/25057296/colonic-smooth-muscle-cells-and-colonic-motility-patterns-as-a-target-for-irritable-bowel-syndrome-therapy-mechanisms-of-action-of-otilonium-bromide
#15
REVIEW
Jakub Rychter, Francisco Espín, Diana Gallego, Patri Vergara, Marcel Jiménez, Pere Clavé
Otilonium bromide (OB) is a spasmolytic compound of the family of quaternary ammonium derivatives and has been successfully used in the treatment of patients with irritable bowel syndrome (IBS) due to its specific pharmacodynamic effects on motility patterns in the human colon and the contractility of colonic smooth muscle cells. This article examines how. OB inhibits the main patterns of human sigmoid motility in vitro, which are spontaneous rhythmic phasic contractions, smooth muscle tone, contractions induced by stimulation of excitatory motor neurons and contractions induced by direct effect of excitatory neurotransmitters...
July 2014: Therapeutic Advances in Gastroenterology
https://www.readbyqxmd.com/read/24998877/%C3%AE-%C3%AE-meatp-mimics-the-effects-of-the-purinergic-neurotransmitter-in-the-human-and-rat-colon
#16
Míriam Martínez-Cutillas, Víctor Gil, Diana Gallego, Noemí Mañé, Pere Clavé, María Teresa Martín, Marcel Jiménez
The purine receptor involved in inhibitory responses in the gastrointestinal tract has been recently identified. P2Y1 receptor activation mediates the fast component of the inhibitory junction potential (IJPf) and the non-nitrergic relaxation. The aim of the present work has been to investigate which purinergic agonist better mimics endogenous responses. We used different agonist and antagonist of P2 receptors. Contractility and microelectrode experiments were used to compare the effects of exogenously added purines and electrical field stimulation (EFS)-induced nerve mediated effects in rat and human colonic strips...
October 5, 2014: European Journal of Pharmacology
https://www.readbyqxmd.com/read/24910216/purinergic-neuromuscular-transmission-in-the-gastrointestinal-tract-functional-basis-for-future-clinical-and-pharmacological-studies
#17
REVIEW
Marcel Jiménez, Pere Clavé, Anna Accarino, Diana Gallego
Nerve-mediated relaxation is necessary for the correct accomplishment of gastrointestinal (GI) motility. In the GI tract, NO and a purine are probably released by the same inhibitory motor neuron as inhibitory co-transmitters. The P2Y1 receptor has been recently identified as the receptor responsible for purinergic smooth muscle hyperpolarization and relaxation in the human gut. This finding has been confirmed in P2Y1 -deficient mice where purinergic neurotransmission is absent and transit time impaired. However, the mechanisms responsible for nerve-mediated relaxation, including the identification of the purinergic neurotransmitter(s) itself, are still debatable...
October 2014: British Journal of Pharmacology
https://www.readbyqxmd.com/read/24882372/oropharyngeal-dysphagia-is-a-prevalent-risk-factor-for-malnutrition-in-a-cohort-of-older-patients-admitted-with-an-acute-disease-to-a-general-hospital
#18
Silvia Carrión, Mateu Cabré, Rosa Monteis, Maria Roca, Elisabet Palomera, Mateu Serra-Prat, Laia Rofes, Pere Clavé
BACKGROUND & AIMS: Oropharyngeal dysphagia and malnutrition are prevalent conditions in the older. The aim of this study was to explore the relationship between oropharyngeal dysphagia, nutritional status and clinical outcome in older patients admitted to an acute geriatric unit. METHODS: We studied 1662 patients ≥70 years consecutively hospitalized with acute diseases, in whom dysphagia could be clinically assessed by the volume-viscosity swallow test and nutritional status with the Mini Nutritional Assessment(®)...
June 2015: Clinical Nutrition: Official Journal of the European Society of Parenteral and Enteral Nutrition
https://www.readbyqxmd.com/read/24688365/pharmacodynamics-of-trpv1-agonists-in-a-bioassay-using-human-pc-3-cells
#19
Daniel Alvarez-Berdugo, Marcel Jiménez, Pere Clavé, Laia Rofes
PURPOSE: TRPV1 is a multimodal channel mainly expressed in sensory neurons. We aimed to explore the pharmacodynamics of the TRPV1 agonists, capsaicin, natural capsaicinoids, and piperine in an in vitro bioassay using human PC-3 cells and to examine desensitization and the effect of the specific antagonist SB366791. METHODS: PC-3 cells expressing TRPV1 were incubated with Fluo-4. Fluorescence emission changes following exposition to agonists with and without preincubation with antagonists were assessed and referred to maximal fluorescence following the addition of ionomycin...
2014: TheScientificWorldJournal
https://www.readbyqxmd.com/read/24417261/irritable-bowel-syndrome-focus-on-otilonium-bromide
#20
REVIEW
Guy Boeckxstaens, Pere Clavé, Enrico S Corazziari, Jan Tack
Irritable bowel syndrome is a prevalent and chronic disorder, characterized by recurrent abdominal pain/discomfort, bloating and altered bowel habits. This condition affects an estimated 10-15% of the population worldwide and impacts heavily on a patient's daily life and ability to work, as well as healthcare resource utilization. Drug therapy aimed at correcting the primary symptoms of diarrhea/constipation/bloating may have little effect on abdominal pain, which results from visceral hypersensitivity. Smooth muscle relaxants or antispasmodics decrease the tone and contractility of intestinal smooth muscle, effectively managing abdominal pain...
February 2014: Expert Review of Gastroenterology & Hepatology
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