keyword
https://read.qxmd.com/read/38520679/thrombin-activatable-fibrinolysis-inhibitor-plasma-levels-and-tafi-thr325ile-genetic-polymorphism-in-a-cohort-of-egyptian-sickle-cell-disease-patients-and-impact-on-disease-severity
#1
JOURNAL ARTICLE
Mona Hamdy, Iman A Shaheen, Mohamed Khallaf, Yasmeen M M Selim
BACKGROUND: Thrombin is a critical protease modulating thrombosis as well as inflammation, which are one of the main pathophysiological mechanisms in sickle vasculopathy, and its levels were reported to be high in sickle cell disease (SCD). The thrombin-thrombomodulin complex activates the TAFI inhibitor of fibrinolysis, which acts by reducing plasmin affinity for its substrate thus hindering fibrinolysis. OBJECTIVE: We aimed to determine the influence of the Thr325Ile single nucleotide polymorphism (SNP) on TAFI antigen levels and potential effects on the severity of SCD in a cohort of Egyptian patients...
March 23, 2024: Pediatric Blood & Cancer
https://read.qxmd.com/read/38517302/the-neurorehabilitation-of-post-stroke-dysphagia-physiology-and-pathophysiology
#2
JOURNAL ARTICLE
Ayodele Sasegbon, Ivy Cheng, Shaheen Hamdy
Swallowing is a complex process involving the precise contractions of numerous muscles of the head and neck, which act to process and shepherd ingested material from the oral cavity to its eventual destination, the stomach. Over the past five decades, information from animal and human studies has laid bare the complex network of neurones in the brainstem, cortex and cerebellum that are responsible for orchestrating each normal swallow. Amidst this complexity, problems can and often do occur that result in dysphagia, defined as impaired or disordered swallowing...
March 22, 2024: Journal of Physiology
https://read.qxmd.com/read/38487558/dedicated-service-for-barrett-s-oesophagus-surveillance-endoscopy-yields-higher-dysplasia-detection-and-guideline-adherence-in-a-non-tertiary-setting-in-the-uk-a-5-year-comparative-cohort-study
#3
JOURNAL ARTICLE
Elizabeth Ratcliffe, James Britton, Harika Yalamanchili, Izabela Rostami, Syed Mujtaba Hasnain Nadir, Mohamed Korani, Ikedichukwu Eruchie, Muhammad Awais Wazirdin, Neeraj Prasad, Shaheen Hamdy, John McLaughlin, Yeng Ang
OBJECTIVE: Barrett's oesophagus (BO) endoscopic surveillance is performed to varying quality, dedicated services may offer improved outcomes. This study compares a dedicated BO service to standard care, specifically dysplasia detection rate (DDR), guideline adherence and use of advanced imaging modalities in a non-tertiary setting. DESIGN/METHOD: 5-year retrospective comparative cohort study comparing a dedicated BO endoscopy service with surveillance performed on non-dedicated slots at a non-tertiary centre in the UK...
January 2024: Frontline Gastroenterology
https://read.qxmd.com/read/38205383/prevalence-and-risk-factors-of-erectile-dysfunction-in-cirrhotic-patients-an-observational-study
#4
JOURNAL ARTICLE
Mohamed Fakhry, Hamdy Mahfouz, Khalid Abdelazeem, Mohamed AbdelSabour, Nour Shaheen, Ahmed Fathy, Amro M Hassan, Hazem Dief, Mohamed El-Nady, Mustafa A Haridy, Omran Mohamed, Safwat Salama, Emad Abdelrazzak, Walid Saber, Tarek Mohamed, Maha Mohamed, Wael Esmat, Eman Fathy, Muhamed Abdelrahim, Rasha Maree
BACKGROUND: Erectile dysfunction (ED) is a prevalent complication observed in male patients with liver cirrhosis; however, there is limited understanding of the etiological determinants responsible for its occurrence. The objective of this investigation is to explore potential contributory factors that underlie the development of ED in male patients with liver cirrhosis. METHOD: A cross-sectional study was conducted on 200 male patients with liver cirrhosis, who were divided into three groups according to the Child score...
2024: Arab Journal of Urology
https://read.qxmd.com/read/38151168/fecal-urgency-in-ulcerative-colitis-impact-on-quality-of-life-and-psychological-well-being-in-active-and-inactive-disease-states
#5
JOURNAL ARTICLE
Gaurav B Nigam, Jimmy K Limdi, Sebastian Bate, Shaheen Hamdy, Dipesh H Vasant
No abstract text is available yet for this article.
December 25, 2023: Clinical Gastroenterology and Hepatology
https://read.qxmd.com/read/37596008/the-assessment-of-dysphagia-after-stroke-state-of-the-art-and-future-directions
#6
REVIEW
Bendix Labeit, Emilia Michou, Shaheen Hamdy, Michaela Trapl-Grundschober, Sonja Suntrup-Krueger, Paul Muhle, Philip M Bath, Rainer Dziewas
Dysphagia is a major complication following an acute stroke that affects the majority of patients. Clinically, dysphagia after stroke is associated with increased risk of aspiration pneumonia, malnutrition, mortality, and other adverse functional outcomes. Pathophysiologically, dysphagia after stroke is caused by disruption of an extensive cortical and subcortical swallowing network. The screening of patients for dysphagia after stroke should be provided as soon as possible, starting with simple water-swallowing tests at the bedside or more elaborate multi-consistency protocols...
September 2023: Lancet Neurology
https://read.qxmd.com/read/37217237/long-term-effect-of-intensive-lifestyle-intervention-on-cardiometabolic-risk-factors-and-microvascular-complications-in-patients-with-diabetes-in-real-world-clinical-practice-a-10-year-longitudinal-study
#7
JOURNAL ARTICLE
Shaheen Tomah, Hongxia Zhang, Marwa Al-Badri, Tareq Salah, Shilton Dhaver, Abdelrahman Khater, Mhd Wael Tasabehji, Osama Hamdy
INTRODUCTION: Intensive lifestyle intervention (ILI) has significantly reduced incidence of diabetes and improved many cardiovascular disease risk factors. We evaluated long-term effects of ILI on cardiometabolic risk factors, and microvascular and macrovascular complications among patients with diabetes in real-world clinical practice. RESEARCH DESIGN AND METHODS: We evaluated 129 patients with diabetes and obesity enrolled in a 12-week translational model of ILI...
May 2023: BMJ Open Diabetes Research & Care
https://read.qxmd.com/read/37194402/magnitude-of-a1c-improvement-in-relation-to-baseline-a1c-and-amount-of-weight-loss-in-response-to-intensive-lifestyle-intervention-in-real-world-diabetes-practice-13%C3%A2-years-of-observation
#8
JOURNAL ARTICLE
Ahmed H Eldib, Shilton Dhaver, Marwa Al-Badri, Tareq Salah, Karim Kibaa, Omnia Elenani, Shaheen Tomah, Hannah Gardner, Osama Hamdy
BACKGROUND: Effect of intensive lifestyle intervention (ILI) on A1C in participants with diabetes is underestimated. A1C improvement is presumed to be dependent on the amount of weight loss. Here, we evaluate the magnitude of A1C change in relation to baseline A1C and the amount of weight loss in participants with diabetes who underwent ILI over 13 years in real-world clinical practice. METHODS: A total of 590 participants with diabetes were enrolled in the Weight Achievement and Intensive Treatment (Why WAIT) program, a 12-week multidisciplinary ILI program designed for real-world clinical practice between September 2005 and May 2018...
May 16, 2023: Journal of Diabetes
https://read.qxmd.com/read/37046323/multidisciplinary-intensive-lifestyle-intervention-improves-markers-of%C3%A2-nonalcoholic-fatty-liver-disease-nafld-in-patients-with-type-1-diabetes-and-obesity-a-retrospective-matched-cohort-study
#9
JOURNAL ARTICLE
Shaheen Tomah, Tareq Salah, Marwa Al-Badri, Shilton Dhaver, Hannah Gardner, Mhd Wael Tasabehji, Osama Hamdy
BACKGROUND: The prevalence of non-alcoholic fatty liver disease (NAFLD) is increasing among patients with type 1 diabetes (T1D) paralleling the increasing prevalence of obesity among this population. However, little is known about the impact of intensive lifestyle intervention (ILI) on NAFLD in patients with T1D. METHODS: Using Hepatic Steatosis Index (HSI), a noninvasive surrogate predictor of NAFLD, we retrospectively evaluated 88 adult patients with T1D and obesity after one year of participating in a 12-week ILI program in real-world clinical practice...
April 12, 2023: Clinical Diabetes and Endocrinology
https://read.qxmd.com/read/37041020/quality-of-life-measures-in-dysplastic-barrett-s-oesophagus-are-comparable-to-patients-with-non-dysplastic-barrett-s-oesophagus-and-do-not-improve-after-endoscopic-therapy
#10
JOURNAL ARTICLE
Elizabeth Ratcliffe, James Britton, Calvin Heal, Richard Keld, Mark Murgatroyd, Robert Willert, John McLaughlin, Shaheen Hamdy, Yeng Ang
OBJECTIVE: Barrett's oesophagus (BO) is a precursor lesion, via dysplastic phases, to oesophageal adenocarcinoma. Although overall risk from BO is low, it has been shown to adversely affect health-related quality of life (HRQOL). The aim was to compare dysplastic BO patients' HRQOL pre-endoscopic therapy (pre-ET) and post-ET. The pre-ET BO group was also compared with other cohorts: non-dysplastic BO (NDBO), those with colonic polyps, gastro-oesophageal reflux disease (GORD) and healthy volunteers...
April 2023: BMJ Open Gastroenterology
https://read.qxmd.com/read/37012703/the-prevalence-and-burden-of-rome-iv-faecal-incontinence-in-ulcerative-colitis-a-cross-sectional-study
#11
JOURNAL ARTICLE
Dipesh H Vasant, Gaurav B Nigam, Sebastian Bate, Shaheen Hamdy, Jimmy K Limdi
BACKGROUND: Despite advances in ulcerative colitis (UC) therapies, a relatively undefined proportion of patients experience faecal incontinence (FI) in the absence of active inflammation. For this group, there remains a significant unmet need with a limited evidence base. AIMS: We aimed to estimate the prevalence and impact of FI in UC. METHODS: In a prospective cross-sectional study, patients with UC completed a series of validated questionnaires, including Rome IV FI criteria, an inflammatory bowel disease (IBD)-specific FI questionnaire (ICIQ-IBD), Hospital Anxiety and Depression Scale and IBD-Control...
April 3, 2023: Alimentary Pharmacology & Therapeutics
https://read.qxmd.com/read/37006987/genetic-variations-of-ferroportin-1-fpn1-8cg-tmprss6-rs855791-and-hemojuvelin-i222n-and-g320v-among-a-cohort-of-egyptian-%C3%AE-thalassemia-major-patients
#12
JOURNAL ARTICLE
Nesrine El-Gharbawi, Iman Shaheen, Mona Hamdy, Somaya Elgawhary, Mohamed Samir, Baher Matta Hanna, Eman Yousief Ali, Eman Ahmed Youssef
UNLABELLED: Iron overload remains a major cause of morbidity and mortality among β-thalassemia major (β-TM) patients. Iron regulatory proteins and their genetic variants together with changes in hepcidin levels in thalassemic patients could affect the disease manifestations. This work aimed to study genetic variations of ferroportin-1 (FPN1-8CG), Transmembrane Serine Protease 6 (TMPRSS6 rs855791) and hemojuvelin (HJV I222N and G320V) genes within a cohort of 97 β-TM Egyptian patients by Polymerase chain reaction Restriction Fragment Length Polymorphism (PCR-RFLP) in comparison to fifty normal control subjects...
April 2023: Indian Journal of Hematology & Blood Transfusion
https://read.qxmd.com/read/36938521/spinal-disinhibition-evidence-for-a-hyperpathia-phenotype-in-painful-diabetic-neuropathy
#13
JOURNAL ARTICLE
Anne Marshall, Alise Kalteniece, Maryam Ferdousi, Shazli Azmi, Edward B Jude, Clare Adamson, Luca D'Onofrio, Shaishav Dhage, Handrean Soran, Jackie Campbell, Corinne A Lee-Kubli, Shaheen Hamdy, Rayaz A Malik, Nigel A Calcutt, Andrew G Marshall
The dominant sensory phenotype in patients with diabetic polyneuropathy and neuropathic pain is a loss of function. This raises questions as to which mechanisms underlie pain generation in the face of potentially reduced afferent input. One potential mechanism is spinal disinhibition, whereby a loss of spinal inhibition leads to increased ascending nociceptive drive due to amplification of, or a failure to suppress, incoming signals from the periphery. We aimed to explore whether a putative biomarker of spinal disinhibition, impaired rate-dependent depression of the Hoffmann reflex, is associated with a mechanistically appropriate and distinct pain phenotype in patients with painful diabetic neuropathy...
2023: Brain communications
https://read.qxmd.com/read/36834570/diagnostic-significance-of-hsa-mir-21-5p-hsa-mir-192-5p-hsa-mir-155-5p-hsa-mir-199a-5p-panel-and-ratios-in-hepatocellular-carcinoma-on-top-of-liver-cirrhosis-in-hcv-infected-patients
#14
JOURNAL ARTICLE
Mona A Eldosoky, Reham Hammad, Asmaa A Elmadbouly, Reda Badr Aglan, Sherihan G Abdel-Hamid, Mohamed Alboraie, Donia Ahmed Hassan, Mohamed A Shaheen, Areej Rushdi, Reem M Ahmed, Alzahra Abdelbadea, Neamat A Abdelmageed, Ahmed Elshafei, Elham Ali, Omaima I Abo-Elkheir, Samy Zaky, Nadia M Hamdy, Claude Lambert
UNLABELLED: Early hepatocellular carcinoma (HCC) diagnosis is challenging. Moreover, for patients with alpha-fetoprotein (AFP)-negative HCC, this challenge is augmented. MicroRNAs (miRs) profiles may serve as potential HCC molecular markers. We aimed to assess plasma homo sapiens-(hsa)-miR-21-5p, hsa-miR-155-5p, hsa-miR-192-5p, and hsa-miR-199a-5p-expression levels as a panel of biomarkers for HCC in chronic hepatitis C virus (CHCV) patients with liver cirrhosis (LC), especially AFP-negative HCC cases, as a step toward non-protein coding (nc) RNA precision medicine...
February 5, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36820995/public-attitudes-towards-covid-19-antibiotic-resistance-preventive-measures-a-multi-center-cross-sectional-study-in-the-arab-countries
#15
JOURNAL ARTICLE
Sarya Swed, Karem R Motawea, Haidara Bohsas, Hidar Alibrahim, Amine Rakab, Wael Hafez, Nour Shaheen, Mohammad Badr Almoshantaf, Shoaib Ahmad, Sifwa Safdar, Lina Taha Khairy, Agyad Bakkour, Ali Hadi Hussein Muwaili, Dhuha Hadi Hussein Muwaili, Fatima Abubaker Abdalla Abdelmajid, Eman Mohammed Sharif Ahmad, Muhammad Mainuddin Patwary, Hazem S Ghaith, Mhd Kutaiba Albuni, Elias Battikh, Bisher Sawaf, Mohamed Elsayed, Nashaat Kamal Hamdy Elkalagi, Sheikh Shoib
BACKGROUND AND AIM: COVID-19 has shown how crucial awareness of the need to protect public health is to global security. Antibiotic resistance due to antibiotic misuse is seen as a worldwide health issue. Antibiotic use was significant during the COVID-19 epidemic, according to several nations. This research aims to investigate public attitudes on COVID-19, antibiotic resistance, and preventive measures during the COVID-19 pandemic in the Middle East. METHODS: An online quantitative cross-sectional study in 17 Arabic nations was carried out between January 3 and March 4, 2022, using a structured questionnaire to evaluate participants' knowledge of COVID-19, their attitudes toward the new standard during the pandemic, and their use of antibiotics, and their resistance to them...
February 23, 2023: Journal of Epidemiology and Global Health
https://read.qxmd.com/read/36546568/dysphagia-treatments-in-parkinson-s-disease-a-systematic-review-and-meta-analysis
#16
JOURNAL ARTICLE
Ivy Cheng, Ayodele Sasegbon, Shaheen Hamdy
BACKGROUND: The majority of patients with Parkinson's disease (PD) develop oropharyngeal dysphagia during the course of their disease. However, the efficacy of dysphagia treatments for these patients remains controversial. Therefore, we conducted this systematic review and meta-analysis to evaluate treatment efficacy based on the evidence from randomized controlled trials (RCTs). METHODS: Five electronic databases were systematically searched from inception date to April 2022...
December 22, 2022: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://read.qxmd.com/read/36315494/anxiety-and-depression-among-patient-s-companions-during-admission-to-the-icu-in-the-omicron-wave-of-covid-19-a-cross-sectional-study-in-aleppo-university-hospital
#17
JOURNAL ARTICLE
Sarya Swed, Fateh Kashkash, Sheikh Shoib, Nour Shaheen, Mohamad Nour Nasif, Karam R Motawea, Ahmed Sallam ElHawary, Yossef Hassan AbdelQadir, Muhammad Mainuddin Patwary, Hidar Alibrahim, Bisher Sawaf, Lina Taha Khairy, Agyad Bakkour, Ali Hadi Hussein Muwaili, Dhuha Hadi Hussein Muwaili, Fatima Abubaker Abdalla Abdelmajid, Nashaat Kamal Hamdy Elkalagi, Mohamed Elsayed, Eman Mohammed Sharif Ahmed, Abdullah Khouri
BACKGROUND: After the COVID-19 pandemic, anxiety and depression have reached high levels, especially after the last wave, Omicron. Healthcare workers in contact with COVID-19 patients or those who come in contact with them may exhibit high levels of anxiety and depression. Therefore, we aimed to assess anxiety and depression symptoms among ICU companions of COVID-19 patients. METHODS: From 30 November 2021 to 1 March 2022, sixth-year medical students at Aleppo University Hospital conducted interviews with the companions of COVID-19 patients who they brought their patient to the ICU centre as part of a cross-sectional quantitative study using the PHQ-9 and GAD-7 tools to gauge their level of anxiety and depression among companions of COVID-19 patients...
2022: PloS One
https://read.qxmd.com/read/36268265/advances-in-the-treatment-of-dysphagia-in-neurological-disorders-a-review-of-current-evidence-and-future-considerations
#18
REVIEW
Ivy Cheng, Adeel Hamad, Ayodele Sasegbon, Shaheen Hamdy
Dysphagia, which refers to difficult and/or disordered swallowing, is a common problem associated with various neurological diseases such as stroke, motor neuron diseases and neurodegenerative diseases. Traditionally, dysphagia treatments are either compensatory, which includes modifications of bolus texture or feeding posture, or rehabilitative, which includes behavioral exercises and sensory stimulation. Despite being widely adopted in clinical practice, recent views have challenged the clinical efficacy of these treatments due to the low level of evidence supported by mainly non-controlled studies...
2022: Neuropsychiatric Disease and Treatment
https://read.qxmd.com/read/36239821/evaluating-the-therapeutic-application-of-neuromodulation-in-the-human-swallowing-system
#19
REVIEW
Ivy Cheng, Ayodele Sasegbon, Shaheen Hamdy
In the last two decades, the focus of neurogenic dysphagia management has moved from passive compensatory strategies to evidence-based rehabilitative approaches. Advances in technology have enabled the development of novel treatment approaches such as neuromodulation techniques, which target the promotion of neurological reorganization for functional recovery of swallowing. Given the rapid pace of development in the field, this review aims to summarize the current findings on the effects of neuromodulation techniques on the human swallowing system and evaluate their therapeutic potential for neurogenic dysphagia...
October 14, 2022: Dysphagia
https://read.qxmd.com/read/36170765/cerebral-control-of-swallowing-an-update-on-neurobehavioral-evidence
#20
REVIEW
Ivy Cheng, Kazutaka Takahashi, Arthur Miller, Shaheen Hamdy
This review aims to update the current knowledge on the cerebral control of swallowing. We review data from both animal and human studies spanning across the fields of neuroanatomy, neurophysiology and neuroimaging to evaluate advancements in our understanding in the brain's role in swallowing. Studies have collectively shown that swallowing is mediated by multiple distinct cortical and subcortical regions and that lesions to these regions can result in dysphagia. These regions are functionally connected in separate groups within and between the two hemispheres...
November 15, 2022: Journal of the Neurological Sciences
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