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https://www.readbyqxmd.com/read/27807279/design-and-implementation-of-pharyngeal-electrical-stimulation-for-early-de-cannulation-in-tracheotomized-phast-trac-stroke-patients-with-neurogenic-dysphagia-a-prospective-randomized-single-blinded-interventional-study
#1
Rainer Dziewas, Satish Mistry, Shaheen Hamdy, Jens Minnerup, Ingeborg Van Der Tweel, Wolf Schäbitz, Philip M Bath
RATIONALE: Ongoing dysphagia in stroke patients weaned from mechanical ventilation often requires long-term tracheotomy to protect the airway from aspiration. In a recently reported single-centre pilot study, a significantly larger proportion (75%) of tracheotomized dysphagic stroke patients regained sufficient control of airway management allowing tracheotomy tube removal (decannulation) 24-72 h after pharyngeal electrical stimulation (PES) compared to controls who received standard therapy over the same time period (20%)...
November 2, 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/27571768/recognizing-the-importance-of-dysphagia-stumbling-blocks-and-stepping-stones-in-the-twenty-first-century
#2
Rainer Dziewas, Anne Marie Beck, Pere Clave, Shaheen Hamdy, Hans Jürgen Heppner, Susan E Langmore, Andreas Leischker, Rosemary Martino, Petra Pluschinski, Andreas Roesler, Reza Shaker, Tobias Warnecke, Cornel Christian Sieber, Dorothee Volkert, Rainer Wirth
No abstract text is available yet for this article.
August 29, 2016: Dysphagia
https://www.readbyqxmd.com/read/27307155/a-longitudinal-study-of-symptoms-of-oropharyngeal-dysphagia-in-an-elderly-community-dwelling-population
#3
Danielle Nimmons, Emilia Michou, Maureen Jones, Neil Pendleton, Michael Horan, Shaheen Hamdy
Dysphagia has been estimated to affect around 8-16 % of healthy elderly individuals living in the community. The present study investigated the stability of perceived dysphagia symptoms over a 3-year period and whether such symptoms predicted death outcomes. A population of 800 and 550 elderly community-dwelling individuals were sent the Sydney Swallow Questionnaire (SSQ) in 2009 and 2012, respectively, where an arbitrary score of 180 or more was chosen to indicate symptomatic dysphagia. The telephone interview cognitive screen measured cognitive performance and the Geriatric Depression Scale measured depression...
August 2016: Dysphagia
https://www.readbyqxmd.com/read/27198495/development-and-feasibility-testing-of-an-oral-hygiene-intervention-for-stroke-unit-care
#4
Craig J Smith, Maria Horne, Giles McCracken, David Young, Ian Clements, Sharon Hulme, Claire Ardron, Shaheen Hamdy, Andy Vail, Angus Walls, Pippa J Tyrrell
OBJECTIVE: To develop an oral hygiene complex intervention and evaluate its feasibility in a single UK stroke centre. BACKGROUND: Oral hygiene interventions might improve clinical outcomes after stroke but evidence-based practice is lacking. MATERIALS AND METHODS: We used a sequential mixed methods approach and developed an oral hygiene complex intervention comprising: (i) web-based education and 'hands-on' practical training for stroke unit nursing staff, (ii) a pragmatic oral hygiene protocol consisting of twice-daily powered (or manual if preferred) brushing with chlorhexidine gel (or non-foaming toothpaste) ± denture care...
May 16, 2016: Gerodontology
https://www.readbyqxmd.com/read/27165955/pharyngeal-electrical-stimulation-for-treatment-of-dysphagia-in-subacute-stroke-a-randomized-controlled-trial
#5
Philip M Bath, Polly Scutt, Jo Love, Pere Clavé, David Cohen, Rainer Dziewas, Helle K Iversen, Christian Ledl, Suzanne Ragab, Hassan Soda, Anushka Warusevitane, Virginie Woisard, Shaheen Hamdy
BACKGROUND AND PURPOSE: Dysphagia is common after stroke, associated with increased death and dependency, and treatment options are limited. Pharyngeal electric stimulation (PES) is a novel treatment for poststroke dysphagia that has shown promise in 3 pilot randomized controlled trials. METHODS: We randomly assigned 162 patients with a recent ischemic or hemorrhagic stroke and dysphagia, defined as a penetration aspiration score (PAS) of ≥3 on video fluoroscopy, to PES or sham treatment given on 3 consecutive days...
June 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27053641/pharyngeal-electrical-stimulation-in-dysphagia-poststroke-a-prospective-randomized-single-blinded-interventional-study
#6
Dipesh H Vasant, Emilia Michou, Neil O'Leary, Andy Vail, Satish Mistry, Shaheen Hamdy
Background Pharyngeal electrical stimulation (PES) appears to promote cortical plasticity and swallowing recovery poststroke. Objective We aimed to assess clinical effectiveness with longer follow-up. Methods Dysphagic patients (n = 36; median = 71 years; 61% male) recruited from 3 trial centers within 6 weeks of stroke, received active or sham PES in a single-blinded randomized design via an intraluminal pharyngeal catheter (10 minutes, for 3days). The primary outcome measure was the Dysphagia Severity Rating (DSR) scale (<4, no-mild; ≥4, moderate-severe)...
October 2016: Neurorehabilitation and Neural Repair
https://www.readbyqxmd.com/read/27006423/post-stroke-dysphagia-a-review-and-design-considerations-for-future-trials
#7
REVIEW
David L Cohen, Christine Roffe, Jessica Beavan, Brenda Blackett, Carol A Fairfield, Shaheen Hamdy, Di Havard, Mary McFarlane, Carolee McLauglin, Mark Randall, Katie Robson, Polly Scutt, Craig Smith, David Smithard, Nikola Sprigg, Anushka Warusevitane, Caroline Watkins, Lisa Woodhouse, Philip M Bath
Post-stroke dysphagia (a difficulty in swallowing after a stroke) is a common and expensive complication of acute stroke and is associated with increased mortality, morbidity, and institutionalization due in part to aspiration, pneumonia, and malnutrition. Although most patients recover swallowing spontaneously, a significant minority still have dysphagia at six months. Although multiple advances have been made in the hyperacute treatment of stroke and secondary prevention, the management of dysphagia post-stroke remains a neglected area of research, and its optimal management, including diagnosis, investigation and treatment, have still to be defined...
June 2016: International Journal of Stroke: Official Journal of the International Stroke Society
https://www.readbyqxmd.com/read/26970368/acceptability-of-oral-solid-medicines-in-older-adults-with-and-without-dysphagia-a-nested-pilot-validation-questionnaire-based-observational-study
#8
Fang Liu, Ambreen Ghaffur, Jackreet Bains, Shaheen Hamdy
Older patients (aged 65years and over) are the major consumers of medicines and many barriers affect their ability in taking medicines orally, especially swallowing difficulties. Moreover, the characteristics of differing medicine formulations might have an impact on their acceptability in older patients. The aims of this study were to validate a Medicines Acceptability Questionnaire (MAQ) and to assess acceptability of oral solid medicines in older ambulatory patients with and without dysphagia. One hundred and fifty six older patients attending community pharmacies were recruited and attended face to face interviews...
March 9, 2016: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/26966356/oropharyngeal-dysphagia-in-older-persons-from-pathophysiology-to-adequate-intervention-a-review-and-summary-of-an-international-expert-meeting
#9
REVIEW
Rainer Wirth, Rainer Dziewas, Anne Marie Beck, Pere Clavé, Shaheen Hamdy, Hans Juergen Heppner, Susan Langmore, Andreas Herbert Leischker, Rosemary Martino, Petra Pluschinski, Alexander Rösler, Reza Shaker, Tobias Warnecke, Cornel Christian Sieber, Dorothee Volkert
Oropharyngeal dysphagia (OD) is a highly prevalent and growing condition in the older population. Although OD may cause very severe complications, it is often not detected, explored, and treated. Older patients are frequently unaware of their swallowing dysfunction which is one of the reasons why the consequences of OD, ie, aspiration, dehydration, and malnutrition, are regularly not attributed to dysphagia. Older patients are particularly vulnerable to dysphagia because multiple age-related changes increase the risk of dysphagia...
2016: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/26897756/repetitive-transcranial-magnetic-stimulation-a-novel-approach-for-treating-oropharyngeal-dysphagia
#10
Emilia Michou, Alicja Raginis-Zborowska, Masahiro Watanabe, Taha Lodhi, Shaheen Hamdy
In recent years, repetitive transcranial magnetic stimulation, a technique used to produce human central neurostimulation, has attracted increased interest and been applied experimentally in the treatment of dysphagia. This review presents a synopsis of the current research for the application of repetitive transcranial magnetic stimulation (rTMS) on dysphagia. Here, we review the mechanisms underlying the effects of rTMS and the results from studies on both healthy volunteers and dysphagic patients. The clinical studies on dysphagia have primarily focussed on dysphagia post-stroke...
February 2016: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/26689491/pharyngeal-electrical-stimulation-for-treatment-of-poststroke-dysphagia-individual-patient-data-meta-analysis-of-randomised-controlled-trials
#11
REVIEW
Polly Scutt, Han S Lee, Shaheen Hamdy, Philip M Bath
Background. Dysphagia after stroke is common, associated independently with poor outcome, and has limited treatment options. Pharyngeal electrical stimulation (PES) is a novel treatment being evaluated for treatment of poststroke dysphagia. Methods. We searched electronically for randomised controlled trials of PES in dysphagic patients within 3 months of stroke. Individual patient data were analysed using regression, adjusted for trial, age, severity, and baseline score. The coprimary outcomes were radiological aspiration (penetration aspiration score, PAS) and clinical dysphagia (dysphagia severity rating scale, DSRS) at 2 weeks; secondary outcomes included functional outcome, death, and length of stay in hospital...
2015: Stroke Research and Treatment
https://www.readbyqxmd.com/read/26627547/oropharyngeal-dysphagia-manifestations-and-diagnosis
#12
REVIEW
Nathalie Rommel, Shaheen Hamdy
Swallowing disorders (dysphagia) have been recognized by the WHO as a medical disability associated with increased morbidity, mortality and costs of care. With increasing survival rates and ageing of the population, swallowing disorders and their role in causing pulmonary and nutritional pathologies are becoming exceedingly important. Over the past two decades, the study of oropharyngeal dysphagia has been approached from various disciplines with considerable progress in understanding its pathophysiology. This Review describes the most frequent manifestations of oropharyngeal dysphagia and the clinical as well as instrumental techniques that are available to diagnose patients with dysphagia...
January 2016: Nature Reviews. Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/26607248/brain-and-behavioral-effects-of-swallowing-carbonated-water-on-the-human-pharyngeal-motor-system
#13
Omsaad Elshukri, Emilia Michou, Hannah Mentz, Shaheen Hamdy
Chemical stimulation of the swallowing network with carbonation and citric acid has been investigated, showing potential benefits on swallowing of dysphagic patients. Despite this, the underlying mechanisms for these effects are not fully understood. Here we investigated the effects of 5 ml liquid bolus swallows of carbonated, citric acid, and still water on a swallowing reaction-time tasks paradigm in 16 healthy adults (8 male, mean age 33 ± 3.7 yr, protocol 1). We then investigated the net effects of "sensory bolus interventions" (40 repeated swallows every 15 s) of the three different liquid boluses on corticobulbar excitability, as examined with single-pulse transcranial magnetic stimulation (TMS) in 16 participants (8 female, mean age 33 ± 3...
February 15, 2016: Journal of Applied Physiology
https://www.readbyqxmd.com/read/26316351/high-frequency-focal-repetitive-cerebellar-stimulation-induces-prolonged-increases-in-human-pharyngeal-motor-cortex-excitability
#14
Dipesh H Vasant, Emilia Michou, Satish Mistry, John C Rothwell, Shaheen Hamdy
KEY POINTS: Neurostimulation is a rapidly emerging approach to swallowing rehabilitation, but cerebellar stimulation has not been explored as a treatment. Such proposed therapies for post-stroke dysphagia have required confirmation of physiological effects and optimisation of parameters in healthy humans prior to translational progression into patient groups. There is strong evidence for a role of the cerebellum in swallowing physiology, but this relationship has been under-explored. Recently, single pulses of cerebellar magnetic stimulation have been shown to directly evoke responses from pharyngeal musculature and produce short-term enhancement of cortico-pharyngeal motor evoked potentials, suggesting the feasibility of a cerebellar approach to neurostimulation in the swallowing system...
November 15, 2015: Journal of Physiology
https://www.readbyqxmd.com/read/26116289/genetic-determinants-of-swallowing-impairments-among-community-dwelling-older-population
#15
Alicja Raginis-Zborowska, Krisztina Mekli, Antony Payton, William Ollier, Shaheen Hamdy, Neil Pendleton
BACKGROUND: Swallowing difficulties (dysphagia) affect a significant proportion of community dwelling older individuals, being more prevalent in age-associated neurological conditions such as stroke and Parkinson's disease. The genetic determinants of dysphagia are still being explored and have largely been studied through candidate gene analysis approaches. The aim of the study was to perform a genome-wide association study (GWAS) of common genetic single nucleotide polymorphisms (SNP) and self-reported swallowing impairments in a longitudinal cohort of community dwelling older adults...
September 2015: Experimental Gerontology
https://www.readbyqxmd.com/read/25976926/fmri-and-mrs-measures-of-neuroplasticity-in-the-pharyngeal-motor-cortex
#16
Emilia Michou, Steve Williams, Rishma Vidyasagar, Darragh Downey, Satish Mistry, Richard A E Edden, Shaheen Hamdy
INTRODUCTION: Paired associative stimulation (PAS), is a novel non-invasive technique where two neural substrates are employed in a temporally coordinated manner in order to modulate cortico-motor excitability within the motor cortex (M1). In swallowing, combined pharyngeal electrical and transcranial-magnetic-stimulation induced beneficial neurophysiological and behavioural effects in healthy subjects and dysphagic stroke patients. Here, we aimed to investigate the whole-brain changes in neural activation during swallowing using functional magnetic resonance imaging (fMRI) following PAS application and in parallel assess associated GABA changes with magnetic resonance spectroscopy (MRS)...
August 15, 2015: NeuroImage
https://www.readbyqxmd.com/read/25867123/modulation-of-human-visceral-sensitivity-by-noninvasive-magnetoelectrical-neural-stimulation-in-health-and-irritable-bowel-syndrome
#17
Tarig Algladi, Mary Harris, Peter J Whorwell, Peter Paine, Shaheen Hamdy
Visceral pain is a particularly difficult symptom to manage in patients with irritable bowel syndrome (IBS). Our aim was to examine whether noninvasive neurostimulation applied to the motor cortex or lumbosacral region can modulate human visceral sensation. Sixteen healthy adult volunteers and 10 patients with IBS were evaluated. Single-pulse lumbosacral magnetic stimulation (LSMS) or transcranial magnetic stimulation (TMS) was used to assess spinal root and cortical excitability as well as the effect of neurostimulation on anorectal sensation and pain, which were provoked by a local electrical stimulus...
July 2015: Pain
https://www.readbyqxmd.com/read/25816754/peripheral-expression-of-hepcidin-gene-in-egyptian-%C3%AE-thalassemia-major
#18
Azza Aboul-Enein, Amal El-Beshlawy, Mona Hamdy, Iman Shaheen, Zainab El-Saadany, Ahmed Samir, Hala Abd El-Samie
Iron overload is the major cause of morbidity and mortality in transfusion dependent β-thalassemia major patients. There is a sophisticated balance of body iron metabolism of storage and transport which is regulated by several factors including the peptide hepcidin. Hepcidin is the main iron regulatory molecule; it is secreted mainly by the liver and other tissues including monocytes and lymphocytes. Expression of hepcidin in such cells is unclear and has been studied in few reports with controverted result...
June 15, 2015: Gene
https://www.readbyqxmd.com/read/24681075/characterization-of-corticobulbar-pharyngeal-neurophysiology-in-dysphagic-patients-with-parkinson-s-disease
#19
Emilia Michou, Shaheen Hamdy, Mary Harris, Adil Vania, Jeremy Dick, Mark Kellett, John Rothwell
BACKGROUND & AIMS: Dysphagia in patients with Parkinson's disease, persisting despite dopaminergic treatment, affects intake of nutrients and medication, and reduces quality of life (QOL). We investigated the neurophysiologic mechanisms that contribute to dysphagia in these patients, on and off L-3,4-dihydroxyphenylalanine (levodopa), using transcranial magnetic stimulation. METHODS: We studied 26 patients with Parkinson's disease (age, 65 ± 9 y; 10 men). Dysphagia and QOL were first assessed with qualitative questionnaires...
December 2014: Clinical Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/24627195/association-between-matrix-metalloproteinase-2-mmp2-promoter-polymorphisms-and-the-susceptibility-to-non-hodgkin-s-lymphoma-in-egyptians
#20
Heba Mahmoud Gouda, Mervat Mamdooh Khorshied, Maha Hamdi El Sissy, Iman Abdel Mohsen Shaheen, Mohsen Mokhtar Abdel Mohsen
Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases capable of extracellular matrix degradation. MMP2 is the key molecule that control invasion, tumor growth, and metastasis, and has been associated with poor prognosis in several tumors. Several epidemiological studies have focused on the associations between MMP2 promoter polymorphisms and cancer susceptibility; however, little is known about their role in hematological malignancies. The present study aimed to investigate the association of MMP2 -735C/T and -1306C/T promoter polymorphisms with B-NHL susceptibility and their clinicopathological characteristics...
August 2014: Annals of Hematology
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