keyword
MENU ▼
Read by QxMD icon Read
search

hepatol

keyword
https://www.readbyqxmd.com/read/27815136/phenylquinoxalinone-cftr-activator-as-potential-prosecretory-therapy-for-constipation
#1
Onur Cil, Puay-Wah Phuan, Jung-Ho Son, Jie S Zhu, Colton K Ku, Niloufar Akhavan Tabib, Andrew P Teuthorn, Loretta Ferrera, Nicholas C Zachos, Ruxian Lin, Luis J V Galietta, Mark Donowitz, Mark J Kurth, A S Verkman
Constipation is a common condition for which current treatments can have limited efficacy. By high-throughput screening, we recently identified a phenylquinoxalinone activator of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel that stimulated intestinal fluid secretion and normalized stool output in a mouse model of opioid-induced constipation (Cil et al Cell Mol Gastroenterol Hepatol 2:317-327, 2016). Here, we report phenylquinoxalinone structure-activity analysis, mechanism of action, animal efficacy data in acute and chronic models of constipation, and functional data in ex vivo primary cultured human enterocytes...
October 15, 2016: Translational Research: the Journal of Laboratory and Clinical Medicine
https://www.readbyqxmd.com/read/27600190/quality-of-meta-analyses-in-major-leading-gastroenterology-and-hepatology-journals-a-systematic-review
#2
Pengfei Liu, Yuanyu Qiu, Yuting Qian, Xiao Chen, Yiran Wang, Jin Cui, Xiao Zhai
BACKGROUND AND AIM: To appraise the current reporting methodological quality of meta-analyses in five leading gastroenterology and hepatology journals, and to identify the variables associated with the reporting quality. METHODS: We systematically searched the literature of meta-analyses in Gastroenterology, Gut, Hepatology, Journal of Hepatology (J HEPATOL) and American Journal of Gastroenterology (AM J GASTROENTEROL) from 2006 to 2008 and from 2012 to 2014. Characteristics were extracted based on the PRISMA statement and the AMSTAR tool...
September 6, 2016: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/27441324/corrigendum-to-%C3%A2-%C3%A2-allo-transplantation-of-mesenchymal-stem-cells-attenuates-hepatic-injury-through-il1ra-dependent-macrophage-switch-in-a-mouse-model-of-liver-disease%C3%A2-j-hepatol-2015-63-1405%C3%A2-1412
#3
https://www.readbyqxmd.com/read/27379644/integrated-neural-and-endocrine-control-of-gastrointestinal-function
#4
John B Furness
The activity of the digestive system is dynamically regulated by external factors, including body nutritional and activity states, emotions and the contents of the digestive tube. The gut must adjust its activity to assimilate a hugely variable mixture that is ingested, particularly in an omnivore such as human for which a wide range of food choices exist. It must also guard against toxins and pathogens. These nutritive and non-nutritive components of the gut contents interact with the largest and most vulnerable surface in the body, the lining of the gastrointestinal tract...
2016: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/27229718/apasl-consensus-statements-and-recommendations-for-hepatitis-c-prevention-epidemiology-and-laboratory-testing
#5
EDITORIAL
Masao Omata, Tatsuo Kanda, Lai Wei, Ming-Lung Yu, Wang-Long Chuang, Alaaeldin Ibrahim, Cosmas Rinaldi Adithya Lesmana, Jose Sollano, Manoj Kumar, Ankur Jindal, Barjesh Chander Sharma, Saeed S Hamid, A Kadir Dokmeci, Mamun Al-Mahtab, Geofferey W McCaughan, Jafri Wasim, Darrell H G Crawford, Jia-Horng Kao, Osamu Yokosuka, George K K Lau, Shiv Kumar Sarin
The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on "APASL consensus statements and recommendations for management of hepatitis C" in March 2015 to revise the "APASL consensus statements and management algorithms for hepatitis C virus infection" (Hepatol Int 6:409-435, 2012). The working party consisted of expert hepatologists from the Asian-Pacific region gathered at the Istanbul Congress Center, Istanbul, Turkey on 13 March 2015. New data were presented, discussed, and debated during the course of drafting a revision...
September 2016: Hepatology International
https://www.readbyqxmd.com/read/27198051/erratum-to-clinical-implications-of-basic-research-in-hepatocellular-carcinoma-j-hepatol-2016-64-736-745
#6
Renumathy Dhanasekaran, Sudhakar K Venkatesh, Michael S Torbenson, Lewis R Roberts
No abstract text is available yet for this article.
June 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27198050/corrigendum-to-alternatively-activated-m2-macrophages-promote-tumour-growth-and-invasiveness-in-hepatocellular-carcinoma-j-hepatol-2015-62-607-616
#7
Oscar W H Yeung, Chung-Mau Lo, Chang-Chun Ling, Xiang Qi, Wei Geng, Chang-Xian Li, Kevin T P Ng, Stuart J Forbes, Xin-Yuan Guan, Ronnie T P Poon, Sheung-Tat Fan, Kwan Man
No abstract text is available yet for this article.
June 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27198049/corrigendum-to-profiles-of-hbv-dna-in-a-large-population-of-chinese-patients-with-chronic-hepatitis-b-implications-for-antiviral-therapy-j-hepatol-2011-54-195-200
#8
James Fung, Wai-Kay Seto, Ching-Lung Lai, John Yuen, Danny Ka-Ho Wong, Man-Fung Yuen
No abstract text is available yet for this article.
June 2016: Journal of Hepatology
https://www.readbyqxmd.com/read/27130427/apasl-consensus-statements-and-recommendation-on-treatment-of-hepatitis-c
#9
EDITORIAL
Masao Omata, Tatsuo Kanda, Lai Wei, Ming-Lung Yu, Wang-Long Chuang, Alaaeldin Ibrahim, Cosmas Rinaldi Adithya Lesmana, Jose Sollano, Manoj Kumar, Ankur Jindal, Barjesh Chander Sharma, Saeed S Hamid, A Kadir Dokmeci, Mamun-Al-Mahtab, Geofferey W McCaughan, Jafri Wasim, Darrell H G Crawford, Jia-Horng Kao, Osamu Yokosuka, George K K Lau, Shiv Kumar Sarin
The Asian-Pacific Association for the Study of the Liver (APASL) convened an international working party on the "APASL consensus statements and recommendation on management of hepatitis C" in March, 2015, in order to revise "APASL consensus statements and management algorithms for hepatitis C virus infection (Hepatol Int 6:409-435, 2012)". The working party consisted of expert hepatologists from the Asian-Pacific region gathered at Istanbul Congress Center, Istanbul, Turkey on 13 March 2015. New data were presented, discussed and debated to draft a revision...
September 2016: Hepatology International
https://www.readbyqxmd.com/read/26201405/apasl-consensus-statements-and-management-algorithms-for-hepatitis-c-virus-infection
#10
Masao Omata, Tatsuo Kanda, Ming-Lung Yu, Osamu Yokosuka, Seng-Gee Lim, Wasim Jafri, Ryosuke Tateishi, Saeed S Hamid, Wan-Long Chuang, Anuchit Chutaputti, Lai Wei, Jose Sollano, Shiv Kumar Sarin, Jia-Horng Kao, Geoffrey W McCaughan
The Asian Pacific Association for the Study of the Liver (APASL) convened an international working party on the "APASL Consensus Statements and Management Algorithms for Hepatitis C Virus Infection" in December, 2010, in order to revise "Asian Pacific Association for the Study of the Liver consensus statements on the diagnosis, management and treatment of hepatitis C virus infection (J Gastroenterol Hepatol 22:615-633, 2007)". The working party consisted of expert hepatologists from the Asian-Pacific region gathered at Makuhari, Chiba, Japan on 19 December 2010...
April 2012: Hepatology International
https://www.readbyqxmd.com/read/26188490/effects-of-preventive-versus-on-demand-nutritional-support-on-paid-labour-productivity-physical-exercise-and-performance-status-during-peg-interferon-containing-treatment-for-hepatitis-c
#11
Ellen J Huisman, Suzanne van Meer, Bart van Hoek, Hanneke van Soest, Karin M J van Nieuwkerk, Joop E Arends, Peter D Siersema, Karel J van Erpecum
BACKGROUND AND OBJECTIVE: Deterioration of nutritional status during PEG-interferon containing therapy for chronic hepatitis C can be ameliorated by preventive nutritional support. We aimed to explore whether such support also affects paid labour productivity, physical exercise and performance status. METHODS: In this prospective randomized controlled trial (J Hepatol 2012;57:1069-75), 53 patients with chronic hepatitis C had been allocated to "on demand" support (n=26: nutritional intervention if weight loss>5%) or preventive support (n=27: regular dietary advice plus energy- and protein-rich evening snack) during PEG-interferon-containing therapy...
April 2016: Clinics and Research in Hepatology and Gastroenterology
https://www.readbyqxmd.com/read/25820798/twenty-year-survival-post-liver-transplant-challenges-and-lessons
#12
EDITORIAL
Sung-Gyu Lee
There have been numerous reports on survival outcomes after liver transplantation with short-term and mid-term follow-up. However, only a few reports are available for 20-year long-term survivors after liver transplantation. In Korea, the first successful deceased donor liver transplantation (DDLT) in a 13-year-old Wilson's disease patient was performed in 1988, and the first successful living donor liver transplantation (LDLT) in 9-month biliary atresia patient was performed in 1994. Because of the severe shortage of deceased donors and delayed launching of LDLT from December 1994, only 38 cases of liver transplantation (two pediatric LDLTs and 36 DDLTs) from 1988 to 1994 were included in this study (Strong and Fawcett, Hepatol Int 2015 [1]...
July 2015: Hepatology International
https://www.readbyqxmd.com/read/25803014/re-rp-myers-h-shah-kw-burak-et-al-an-update-on-the-management-of-chronic-hepatitis-c-2015-consensus-guidelines-from-the-canadian-association-for-the-study-of-the-liver-can-j-gastroenterol-hepatol-2015-29-1-19-34
#13
Robert P Myers, Hemant Shaw, Kelly W Burak
No abstract text is available yet for this article.
March 2015: Canadian Journal of Gastroenterology & Hepatology
https://www.readbyqxmd.com/read/25755318/prevalence-of-genotype-d-and-precore-core-promoter-mutations-in-hepatitis-b-virus-infected-population-of-north-india
#14
Rajesh Kumar, Vikas Pahal, Jasbir Singh
Hepatitis B virus (HBV) isolates (21) from Punjab (North India) were studied for genotype distribution and precore/core promoter mutations. Assays of alanine aminotransaminase (ALT) and HBeAg were performed in all isolates. Genotypes were determined in all the samples by restriction fragment length polymorphism and the precore/core promoter mutations were studied by amplification and by direct sequencing of precore/core promoter region. Sixty-two percent of the isolates had higher ALT levels and 57% of the isolates were HBeAg negative...
September 2011: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/25751394/mindin-regulates-vascular-smooth-muscle-cell-phenotype-and-prevents-neointima-formation
#15
Li-Hua Zhu, Ling Huang, Xiaojing Zhang, Peng Zhang, Shu-Min Zhang, Hongjing Guan, Yan Zhang, Xue-Yong Zhu, Song Tian, Keqiong Deng, Hongliang Li
Mindin/spondin 2, an extracellular matrix (ECM) component that belongs to the thrombospondin type 1 (TSR) class of molecules, plays prominent roles in the regulation of inflammatory responses, angiogenesis and metabolic disorders. Our most recent studies indicated that mindin is largely involved in the initiation and development of cardiac and cerebrovascular diseases [Zhu et al. (2014) J. Hepatol. 60, 1046-1054; Bian et al. (2012) J. Mol. Med. 90, 895-910; Wang et al. (2013) Exp. Neurol. 247, 506-516; Yan et al...
July 2015: Clinical Science (1979-)
https://www.readbyqxmd.com/read/25538970/retraction-notice-to-clinical-significance-of-the-best-response-during-repeated-transarterial-chemoembolization-in-the-treatment-of-hepatocellular-carcinoma-j-hepatol-2014-60-1212%C3%A2-1218
#16
https://www.readbyqxmd.com/read/25334454/igg4-related-disease-atypical-presentation-of-a-rare-disease
#17
Miti Maniar, Fatima Mamnoon, Prahlad Prabhudesai, Abhijeet Khandelwal, Santosh Jha
Miscellaneous Global Case ReportsSESSION TYPE: Global Case ReportPRESENTED ON: Tuesday, October 28, 2014 at 01:30 PM - 02:30 PMINTRODUCTION: IgG4-related disease (IgG4-RD) is characterized by lymphoplasmacytic tissue infiltration with a predominance of IgG4-positive plasma cells and T lymphocytes, usually accompanied by fibrosis, obliterative phlebitis, and elevated serum levels of IgG4. Modest tissue eosinophilia is also common. A good initial therapeutic response to glucocorticoids is characteristic, particularly if excessive tissue fibrosis has not supervened...
October 1, 2014: Chest
https://www.readbyqxmd.com/read/25333810/how-will-we-manage-acute-hcv-in-men-having-sex-with-men-in-the-era-of-all-oral-therapy
#18
REVIEW
C Boesecke, J K Rockstroh
With the advent of direct-acting antivirals (DAAs), the treatment of chronic hepatitis C virus (HCV) infection (CHC) has been revolutionized. Modern interferon- and potentially also ribavirin-free combinations consisting of 2 or 3 direct-acting antivirals (DAA) promise sustained virological response rates (SVR) of above 90%. This coincides with much shorter treatment durations and a much more favorable toxicity profile. Some DAAs even work across all HCV genotypes (pangenotypic) [BMJ, 349, 2014, g3308]. And lastly, HCV treatment in HIV-coinfected patients will no longer differ from HCV-monoinfected patients as response rates under DAA in the setting of HCV-HIV coinfection have been as good as in HCV-monoinfected patients [J Hepatol, 61, 2014, 373]...
January 2015: Journal of Viral Hepatitis
https://www.readbyqxmd.com/read/24412858/chronic-ethanol-ingestion-induces-oxidative-kidney-injury-through-taurine-inhibitable-inflammation
#19
Calivarathan Latchoumycandane, Laura E Nagy, Thomas M McIntyre
Chronic ethanol ingestion mildly damages liver through oxidative stress and lipid oxidation, which is ameliorated by dietary supplementation with the anti-inflammatory β-amino acid taurine. Kidney, like liver, expresses cytochrome P450 2E1 that catabolizes ethanol with free radical formation, and so also may be damaged by ethanol catabolism. Sudden loss of kidney function, and not liver disease itself, foreshadows mortality in patients with alcoholic hepatitis [J. Altamirano, Clin. Gastroenterol. Hepatol. 2012, 10:65]...
April 2014: Free Radical Biology & Medicine
https://www.readbyqxmd.com/read/23899279/interaction-of-type-2-diabetes-and-nonalcoholic-fatty-liver-disease
#20
COMMENT
John Paul Verderese, Zobair Younossi
Evauation of: Kasturiratne A, Weerasinghe S, Dassanayake A et al. Influence of non-alcoholic fatty liver disease on the development of diabetes mellitus. J. Gastroenterol. Hepatol. 28(1), 142-147 (2013). It has been a few decades that Type 2 diabetes has been clearly linked to the development and progression of nonalcoholic fatty liver disease (NAFLD). In a recent study reported by Kastuiratne et al., the reverse scenario is also reported. In this study, a cohort of Sri Lankan adults were evaluated for NAFLD by ultrasound and for the presence of Type 2 diabetes...
July 2013: Expert Review of Gastroenterology & Hepatology
keyword
keyword
82076
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"